Consider This from NPR - Hidden Viruses And How To Prevent The Next Pandemic

Episode Date: February 3, 2023

More than three years since the start of the COVID pandemic, infectious disease experts are studying other viruses with pandemic potential. Their goal is to understand how pandemics begin and how they can be prevented.This is the focus of the NPR series "Hidden Viruses: How Pandemics Really Begin." In this episode, NPR's Ari Daniel takes us to Bangladesh, where researchers studied a dangerous virus called "Nipah" and how it spreads. In participating regions, you'll also hear a local news segment to help you make sense of what's going on in your community.Email us at [e-mail] more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

This message comes from Indiana University. Indiana University performs breakthrough research every year, making discoveries that improve human health, combat climate change, and move society forward. More at iu.edu slash forward. If you had to pick a specific day when it felt like COVID-19 first became really scary. You might pick January 30th, 2020. That was the day that Dr. Tedros Adhanom Ghebreyesus, director general of the World Health Organization, made this announcement. I'm declaring a public health emergency of international concern over the global outbreak of novel coronavirus. Three years later, it seems that the end of the COVID-19 pandemic is near. Here's President Biden speaking to CBS's 60 Minutes back in September.

The pandemic is over. We still have a problem with COVID. We're still doing a lot of work on it. It's, but the pandemic is over. And just this week, the Biden administration informed Congress that it will formally end the national COVID public health emergency on May 11th. While some people may be very happy to hear that, Lawrence Gostin, a professor of global health at Georgetown University, fears the announcement might cause some people to be apathetic about COVID. What I worry about most is public messaging. When CDC now asks you to wear a mask or to get a booster, American eyes might roll, and that can't be a good thing. Other experts point out that there are other diseases with pandemic potential. They are still out there. Here's Emily Gurley, an epidemiologist at Johns Hopkins University. Pathogens that can transmit between people, those are the ones that I think we should really keep our eye on. Consider this. As one pandemic emergency nears its official end here in the U.S.,

scientists are working around the world to better understand how pandemics begin and how we can stop the next one from happening at all. From NPR, I'm Mary Louise Kelly. It's Friday, February 3rd. This message comes from WISE, the app for doing things in other currencies. Send, spend, or receive money internationally and always get the real-time mid-market exchange rate with no hidden fees. Download the WISE app today or visit WISE.com. T's and C's apply. It's Consider This from NPR. How can we stop the next pandemic? Well, that is a question scientists are working on more than three years since the start of the COVID-19 emergency. And it is the focus of a new NPR series called Hidden Viruses, How Pandemics Really Begin.

The first Back in the early 2000s, when Nipah started showing up in villages in Bangladesh, it struck hard and it struck fast, killing most of its victims. Nipah is terrifying, unusually terrifying. Stephen Luby was based at an international research organization in Bangladesh and led Nipah outbreak investigations at the time. While outbreaks of Nipah can be small, they do happen nearly every year. In fact, two villagers in Bangladesh died from the virus recently. But researchers in that country have figured out a way to stop the virus if people would only listen. NPR's Ari Daniel brings us this tale from a part of the world known as

the Nipah Belt. It's early morning in a lush rural community in central Bangladesh. I'm with a group and we've just made a pit stop in a village within the district of Foridpur, deep in the heart of the Nipah Belt. It's the start of the season when sap is harvested from date palm trees and is then turned into molasses. That's what I'm here to see. I walk up to a huge metal tray over a fire. Gallons of caramel-colored sap are at a rolling boil, thickening into molasses. Mohammad Saraj Khan is the 74-year-old property owner.

No, no, Mr. Mazan. This is actually a delicacy in Bangladesh. Mostly we make cakes and sweets with it. Then I'm offered some of the raw sap to drink. And there it is, the slightly cloudy liquid I've heard so much about. A delicacy and possible poison all at once. I was warned that this exact thing might happen. I was given advice about what to say. The evening before, just a few miles away, I pay a visit to a local family.

A 50-year-old man named Kokon sits outside his home beside a rice paddy. Think Zeus, but more casual. A fiery beard dyed a bright orange rings his chin. And he says he'll never forget the spring of 2004, when the procession of disease and death came on suddenly. The first one was the mother-in-law of my elder brother. She was really sick. She had been sick for some time. Then she died. We took her to the grave. Then my father got sick.

Kokon stares off into the distance as he tells me his father was a spiritual leader in the community. When he became ill, many came to pay their respects. Just 12 days after my father died. Suddenly, he was no more. As for the visitors, they also got sick. One traveled to an adjacent village where four more people fell ill. It was not understood what was happening. Mahmood Ar-Rahman is the former director of the Institute of Epidemiology,

Disease Control and Research for the Bangladeshi government. Some people who were transporting the patients to the hospital were also getting sick. Sick often meant encephalitis, a swelling of the brain. Epidemiologist Emily Gurley, now at Johns Hopkins University, was leading an on-site investigation at the time. The signs and symptoms of encephalitis are, well, fever, headache, but often altered mental status or coma, seizures. Then Kokon and his wife Anwara fell ill.

It's why I'm only using their first names, because the disease carries stigma. People couldn't say if we were dead or alive. They said that we had high fever. Like whenever they were touching us, it was like touching fire. Miraculously, they both survived. But Kokon's older brother, his sister, two uncles, his aunt, his nephew, and his mom and dad, all dead. This outbreak, says Dr. Rahman, made something brutally evident. This is obviously showing that we are unable to control it and it is spreading. And with roughly 70% of those who got it dying, what virus could be that lethal?

We didn't know. I was just looking at the data. I was just looking at data to see what do we think is going on here. A few weeks later, Gurley and her colleagues got an email from the CDC in Atlanta that this was the Nipah virus. They knew the virus came from bats because in the 90s in Malaysia, when it first emerged, Nipah was spreading from local fruit bats to pigs to pig farmers. That's bad enough. But in Bangladesh, the virus was behaving differently. It was being transmitted person to person, which had never been reported before. So that was a scary time. An urgent question hung over Gurley. Just how did Nipah spill over from bats into humans in the first place? That was what needed answering

to shut this thing down. So what we did is walk through the village and thought about all the possible ways people could come into contact with bats or bat secretions, bat urine, bat saliva. Finding this link, it's agonizingly slow work that takes years because an outbreak blazes quickly, the victims are dead, and eyewitnesses often flee or clam up. But the outbreaks kept happening almost every year afterwards, which was deeply worrying to experts, because each time the virus leaps from bat to person, it gets another opportunity to mutate, possibly becoming more transmissible. The fear being the right combination of mutations could propel it into the realm of a deadly pandemic. Finally, the connection emerged, one that offered a remedy for stopping the Nipah spillovers.

But the researchers needed more evidence. In 2007, they got their chance. Our colleague called me and asked, Rebecca, would you like to go? Are you ready? I said, yes, I'm ready to go there. The next morning, anthropologist Rebecca Sultana joined the Nipah outbreak investigation team. She's with the International Center for Diarrheal Disease Research Bangladesh, or ICDDRB for short. When she arrived in the village, she went straight to the home of patient zero. I tried to talk to the elder sister-in-law of the guy who died,

and she was so upset and she just ran and came to me and hugged me and started crying. Getting that close to her scared Sultana. As one Nipa researcher told me, doing this work is like putting your soul in your hand. But Sultana, she hugged her back and said, Please don't worry. We are here to understand why this happened. She asked the community to meet her in the town market to help her draw a map of the village. About two dozen people showed up. She asked the community to meet her in the town market to help her draw a map of the village. About two dozen people showed up.

I don't do anything. I just ask questions and then they draw it. They draw it? Yeah, they draw it. Using sticks in the dirt, the residents roughed out houses, roads, bat roosts, and then they began sketching in date palm trees. This is the first time the people informed me, you know there is a date palm tree and there is a sap harvester in this community. Sultana hadn't seen the date palm trees on the drive-in, but staring back at her from the dirt, there it was, the possible link between how the

fruit bats had passed Nipah into this community through the drinking of the sweet sap. Emily Gurley. I thought, well, this would be a great way to have contact with bat secretions because I'm sure the bats love the sap and so do people. So Rebecca Sultana and her colleagues tracked down that sap harvester and he led them to a few pals of the guy who was patient zero. They said we all used to drink raw sap in the morning. This was Sultana's aha moment, that patient zero had had raw sap before the morning. This was Sultana's aha moment, that patient zero had had raw sap before

falling ill. The line between the bats, the sap, and the outbreaks was becoming clear. So it's a long journey. And one that kept going. Over the next few years, researchers took infrared cameras and caught the bats at night drinking from, and sometimes peeing into, the same stream of sap that people were harvesting. Eventually, the government had enough evidence to launch a campaign against the drinking of raw sap. Some heard that message, but many people have continued to drink the sap, and the spillovers of Nipah virus from bats to people have continued too. It's December 1st, the beginning of what's known around here notoriously as Nipah season, the four months when the virus is most likely to show up. This is when the sap is

harvested and when Ashraful Islam keeps an especially close eye on Nipah. If we want to contain the virus, we have to understand the virus. It's three in the morning. Islam stops at the edge of a patch of forest and looks up into the sky. Some four stories above the ground, a net stretches between two mahogany trees. Why are we out here so early? Because the bears will start coming back from foraging after three. So this is the best time to catch them. Islam is a veterinarian and infectious disease specialist at the ICDDRB. He's searching for another way to stop Nipah. Every month, he brings a team out here near Foridpur to capture bats.

The answer isn't getting rid of these animals. Islam has great respect for their importance to the local ecosystem. Rather, years of studying thousands of greater Indian fruit bats have shown that most of them do carry Nipah virus. But here's the thing. Fewer than 1% of them actually release it into the environment through their urine or saliva. Why do so few of these animals shed the virus?

Islam thinks for that small group, it's likely connected to stress. Is it lack of food? Is it pregnancy stress? Is it lack of habitat? Knowing what's behind the shedding could help Islam and his colleagues figure out how to keep Nipah from infecting people in the first place. The coming dawn is full of sound. There are jackals and fruit bats. What just happened? We are able to catch our bat. Okay, so a bat just flew into the net.

The bat's body is like a brown and furry, and the wings are just deep black, like a silky papery fabric. If you go around, you'll see the big eyes. I gaze into them, like two orbs of amber. She's big. An adult's wingspan easily reaches three feet. If it gets a chance, it will bite you like 10, 15 times. They're very bitey. Just untangled it. The team nabs one more bat and then calls it quits. It's getting too light. They put the bats into a three-wheeler and ferry them to a local lab,

an unassuming one-room building, and yet a crucial outpost in the battle against Nipah. It's where the researchers will sample blood and urine from the bats, and once they're done, they'll release the animals back into the woods. It's on the drive to the lab when Islam makes a pit stop in that village. He wants to show me the date palm trees, the boiling molasses. That's when he'd given me that advice. It is possible that they will offer you a glass of sap.

Please gently deny it, okay? The bubbling molasses I see before me is harmless. Any virus gets cooked away. And to be fair, Khan, the property owner, he doesn't recommend drinking it raw. But before we leave, sure enough, I'm offered a taste of the cool, cloudy sap, a chalice of what could be delectable poison. I smell the sweet air, and I politely decline.

NPR's Ari Daniel, reporting from Bangladesh. You can find a link to our Hidden Viruses series in the notes to this episode. It's Consider This from NPR. I'm Mary Louise Kelly. This message comes from Indiana University. Indiana University is committed to moving the world forward, working to tackle some of society's biggest challenges. IU makes bold investments in the future of bioscience and cybersecurity, cultivates visionary work in the arts and humanities, and prepares students to become visionary work in the arts and humanities,

and prepares students to become global citizens by teaching more languages than any other university in the country. Indiana University. Nine campuses, one purpose. Creating tomorrow, today. More at iu.edu.