From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing. Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.
63 episodes transcribedWhy does life favor one molecular mirror image? The 2026 Nobel Prize in Chemistry honors Henri B. Kagan and Kenso Soai for nonlinear effects and autoc...
Why build a telescope inside a billion tons of Antarctic ice? The 2026 Nobel Prize in Physics recognizes Francis Halzen's work on IceCube and the disc...
How do you prove what a brain cell actually does? The 2026 Nobel Prize in Medicine celebrates a remarkable answer: give cells a light-sensitive protei...
Who could win the 2026 Nobel Prizes? From the science behind Ozempic to quantum interference and droplets inside living cells, Lester Nare and Krishna...
What connects a noise complaint, holiday lights seen from space, and the physics of a coffee stain? Three unexpected paths from basic research to disc...
What does it mean to solve an equation that describes almost every fluid around us, from the air over a wing to the water swirling down a drain?In Epi...
What science should you be watching this fall? From Nobel Prize season to NASA’s Roman Space Telescope, Mars’ moons and Mercury, Lester Nare and Krish...
What can a yak living thousands of meters above sea level teach us about repairing the human brain?In Episode 56 of From First Principles, Lester Nare...
Which quantum computer will actually scale?In Part 2 of our quantum computing deep dive, Lester Nare and Krishna Choudhary move from theory to hardwar...
Which quantum computer will actually scale?In Part 2 of our quantum computing deep dive, Lester Nare and Krishna Choudhary move from theory to hardwar...
Quantum computers do not simply “try every answer at once.” So what do they actually do—and why have governments and technology companies spent billio...
Claude did not solve the Riemann Hypothesis. But what it actually did may be one of the clearest examples yet of how rapidly AI systems are changing t...
In this anniversary episode, Lester Nare and Krishna Choudhary look back at how two longtime friends turned their regular conversations about science...
What happens when electronics can operate at temperatures hot enough to melt aluminum?In this deep-dive episode, Lester Nare and Krishna Choudhary exa...
Hosted by Lester Nare and Krishna Choudhary, this episode moves from astrobiology to science policy to the rapidly changing frontier of artificial int...
In this special interview episode, Lester Nare speaks with Juan Busso, Senior Football Data Scientist at FIFA, and Arron Ackerman, FIFA’s Team Lead fo...
Hosted by Lester Nare and Krishna Choudhary, this episode returns to the FFP science rundown with stories spanning astrophysics, precision medicine, m...
Hosted by Lester Nare and Krishna Choudhary, this episode is part two of our July 4th America 250 special: a celebration of the scientific, technologi...
Hosted by Lester Nare and Krishna Choudhary, this episode is part one of our July 4th America 250 special: a celebration of the scientific, technologi...
Hosted by Lester Nare and Krishna Choudhary, this episode is our World Cup special — a deep dive into the science, physics, engineering, and data behi...
