Huberman Lab - Dr. Peter Attia: Exercise, Nutrition, Hormones for Vitality & Longevity

Starting point is 00:00:00 Welcome to the Uberman Lab podcast where we discuss science and science-based tools for everyday life. I'm Andrew Uberman and I'm a professor of neurobiology and Ophthalmology at Stanford School of Medicine. Today my guest is Dr. Peter Atia. Dr. Atia is a physician who's focused on nutritional, supplementation-based, behavioral, prescription drug, and other interventions that promote health span and lifespan. His expertise spans from exercise physiology to sleep physiology, emotional and mental health

Starting point is 00:00:34 and pharmacology. Today, we talk about all those areas of health, starting with the very basics, such as how to evaluate one's own health status and how to define one's health trajectory. We also talk about the various sorts of interventions that one can take in order to optimize vitality while also extending longevity, that is lifespan. Dr. Atia is uniquely qualified to focus on the complete depth and breadth of topics that we cover.

Starting point is 00:01:01 And indeed, these are the same topics that he works with his patients on in his clinic every day. Dr. Atea earned his Bachelor of Science in Mechanical Engineering and Applied Mathematics and his MD from Stanford University School of Medicine. He then went on to train at Johns Hopkins Hospital in General Surgery, one of the premier hospitals in the world, where he was the recipient of several prestigious awards, including Resident of the Year.

Starting point is 00:01:23 He's been an author on comprehensive reuse of general surgery. He spent two years at the National Institutes of Health as a surgical oncology fellow at the National Cancer Institute, where his work focused on immune-based therapies for melanoma. In the fields of science and medicine, it is well understood that we are much the product of our mentors and the mentoring we receive. Dr. Athea has trained with some of the best and most innovative lipidologist, endocrinologist, gynecologist, sleep physiologist, and longevity scientist in the United States and Canada. So the expertise that funnels through him and that he shares with

Starting point is 00:01:55 us today is really harnessed from the best of the best and his extensive training and expertise. By the end of today's episode, you will have answers to important basic questions such as, should you have blood work? How often should you do blood work? What specific things should you be looking for on that blood work that are either counterintuitive or not often discussed and yet that immediately and in the long term influence your lifespan and health span? We talk about hormone health and hormone therapies for both men and women.

Starting point is 00:02:25 We talk about drug therapies that can influence the mind as well as the body. And of course, we talk about supplementation, nutrition, exercise, and predictors of lifespan and health span. It is an episode rich with information. For some of you, you may want to get out a pen and paper in order to take notes for others of you that learn better simply by listening. I just want to remind you that we have timestamped all this information so that you can go back to the specific topics most of interest to you. Before we begin, I'd like to emphasize that this podcast is separate from my teaching and research roles at Stanford.

Starting point is 00:02:57 It is, however, part of my desire and effort to bring zero cost to consumer information about science and science-related tools to the general public. In keeping with that theme, I'd like to thank the sponsors of today's podcast. Our first sponsor is Element. Element is an electrolyte drink with everything you need and nothing you don't. That means plenty of salt, magnesium, and potassium, the so-called electrolytes, and no sugar. Salt, magnesium, and potassium are critical to the function of all the cells in your body, in particular to the function of your nerve cells, also called neurons. In fact, in order for your neurons to function properly, all three electrolytes need to be present in the proper ratios.

Starting point is 00:03:34 And we now know that even slight reductions in electrolyte concentrations or dehydration of the body can lead to deficits in cognitive and physical performance. Element contains a science-backed electrolyte ratio of 1000 milligrams, that's 1 gram of sodium, 200 milligrams of potassium and 60 milligrams of magnesium. I typically drink element first thing in the morning when I wake up in order to hydrate my body and make sure I have enough electrolytes. And while I do any kind of physical training and after physical training as well, especially if I've been sweating a lot, if you'd like to try element, you can go to DrinkElement, that's LMNT.com slash Huberman

Starting point is 00:04:10 to claim a free element sample pack with your purchase. Again, that's DrinkElementLMNT.com slash Huberman. And now for my discussion with Dr. Peter Atia. Peter, thanks for joining me today. Thanks for having me now. I've been looking forward to this for a very long time. That's why. Am I huge fanning your podcast? Peter, thanks for joining me today. Thanks for having me, man. I've been looking forward to this for a very long time. That's why.

Starting point is 00:04:26 Am I a huge fan of your podcast? I know that you went to Stanford and worked with a number of people that are colleagues of mine. So for me, this is already a thrill, just to be doing this. Yeah, well, it's a big question. I have a ton of questions,

Starting point is 00:04:39 but I want to start off with something that I wonder a lot about, and then I know many other people wonder about, which is how to assess their current health and their trajectory in terms of health and wellbeing, specifically as it relates to blood work. So what are your thoughts on blood work? Is it necessary for the typical person? So this is somebody who's not dealing with some acute syndrome or illness. And at what age would you suggest

Starting point is 00:05:05 people start getting blood work? How frequently should they get blood work? How often do you get blood work done, et cetera? Yeah, there's a lot there. I mean, the way I talk about this with patients is first taking everything back to the objective. So what's the thing we're trying to optimize? So if a person says, look, I'm trying to break 10 hours

Starting point is 00:05:26 for an Iron Man, I don't know that blood work is going to be a game-changing aspect of their trajectory and their training. You know, they're going to benefit much more from sort of functional analyses of performance. So I'm assuming, based on the question, that you're really coming at this through the lens of living longer and living better through the lifespan health span.

Starting point is 00:05:48 Most lens? Yeah. And just I think most people have some sense of their vitality or lack of vitality. But I think everyone wonders whether or not they could feel better and whether or not blood work will give them a window into how they might go about feeling better. Yeah, I think it does to some extent, but I also think that it has a lot of blind spots. So I kind of break things down into the two vectors that make up longevity, which are lifespan and health span. So lifespan is the easiest of those vectors to understand because it's pretty binary. You're alive or you're not alive, you're aspiring

Starting point is 00:06:20 or you're not, you make ATP or you don't. End of story. So what gets in the way of lifespan is essentially the forehorsement of disease. Right. So, atherosclerotic disease, cancer, neurodegenerative disease, and metabolic disease, which directly isn't the cause of many deaths, but, you know, basically creates the foundation to all of those other diseases. you know, basically creates the foundation to all of those other diseases. So, you know, if you're a non-smoker, what I just rattled off is about 80% of your death.

Starting point is 00:06:57 So, how does blood work help address those? It varies. So, on the atherosclerotic standpoint, it's a very good predictor of risk if you know what to look for. So, primarily APOB would be the single most important um, life-approaching that we care about. I can explain what that means in a second. And then also, you know, other markers of inflammation and ethereal health and metabolic health. When it comes to cancer, you know, blood testing in the sense of biomarkers is not particularly helpful outside of knowing that the second leading environmental or modifiable cause of cancer is metabolic ill health after smoking.

Starting point is 00:07:29 So we don't actually know a lot about cancer in the sense of what causes it. It's really stochastic and it's a lot of bad luck. So we know that smoking drives it and we know that even though epidemiologically we say obesity drives it, what it really means is metabolic poor health. It's probably the hyperinsulinemia that comes with obesity that drives it. So biomarkers help with that, but there's still an enormous blind spot to answer. We could talk about liquid biopsies aside because those aren't really biomarkers studies, but that way.

Starting point is 00:07:58 On the neurodegenerative side, I don't think we have a lot of insight that comes to understanding Parkinson's disease, but when it comes that comes to understanding Parkinson's disease, but when it comes to dementia, particularly Alzheimer's disease, which is the most prevalent form of dementia, I think the biomarkers can be quite helpful. They overlap a lot with the atherosclerotic diseases. So, the same things that drive the risk of heart disease are driving the risk of dementia. And then there's some novel stuff as well. If you include genetic testing, which you can get out of a blood test, we get a whole suite of genes, not just ApoE, but far more, you know, nuanced stuff than that that can

Starting point is 00:08:29 also play a role. So you can stratify risk in that sense. So in aggregate, I would say, you know, blood testing of biomarkers provides pretty good insight into lifespan. When you get into health span, you have the cognitive physical, emotional domains. I think here the biomarkers are far less helpful, and here we rely more on functional testing. When it comes to the cognitive piece, you can do cognitive testing. In terms of long-term risk, a lot of the things that imply good cognitive health as you age

Starting point is 00:09:06 are in line with the same things that you would do to reduce the risk of dementia. So all the biomarkers that you would look to improve through dementia risk reduction, you would be improving through cognitive health. On the physical side, I mean, outside of looking at hormone levels and things which we look at extensively and understanding how those might aid in or prevent some of the metrics that matter, it really is, this is a biomarker aside thing. I mean, I'd be much more interested

Starting point is 00:09:31 in a person's DEXA CPET testing, VO2 max testing, zone-to-lactate testing, fat oxidation, those what I consider more functional tests that give me far more insight into that. And then, of course, the emotional piece, which depending on, you know, who you are might be the single most important piece without which none of this other stuff matters. Or if you're totally miserable, human being, your relationship suck. I don't think any of this other stuff matters. And certainly there's nothing that I'm looking at in biomarkers.

Starting point is 00:09:58 It's giving me great insight into that. Do you ask about emotional state, or do you try and assess emotional state indirectly when you do an intake with one of your patients? Probably not so much in the intake, because I think it takes a while to form a relationship with a patient before that starts to become something that they're necessarily gonna wanna talk with you about,

Starting point is 00:10:17 but I definitely think of it as an important part of what we do, and I think without it, none of this other stuff really matters. Again, the irony of thinking about how many years I spent sort of in pursuit of fully optimizing every detail of everything without any attention being paid to that dimension is not lost on me. And look, there are some patients who that's just not something that's something that's compartmentalized. Maybe they're doing well in that department, or maybe they aren't, but they just aren't willing to engage in that yet.

Starting point is 00:10:48 In terms of frequency of blood testing, if somebody feels pretty good and is taking a number of steps, exercise, nutrition, et cetera, to try and extend lifespan and improve health span is once a year frequent enough and should a 20-year-old start getting blood work done just to get a window into what's going on, assuming that they can afford it or their insurance can cover it. Yeah, I mean, look, I certainly think everybody should be screened early in life because if you look at like what's the single most prevalent genetic driver of atherosclerosis is LPL L.A. So unfortunately, most physicians don't know what LPLitLA is, and yet somewhere between 8 and 12% of the population has a high enough, and depending on who you, you know, I had

Starting point is 00:11:33 a recent guest on my podcast who suggested it could be as high as 20% have a high enough LPLitLA that it is contributing to atherosclerosis. So to not want to know that when it's genetically determined, right? This is something that, you know, you're born with this and you only need to really check it once. Why we wouldn't want to know that in a 20-year-old, when it can contribute to a lot of the early atherosclerosis we see in people, you know, it's leaving money on the table in my opinion. The frequency with which you need to test really comes down to the state of interventions.

Starting point is 00:12:05 I don't think it makes sense to just do blood tests for the sake of doing blood tests. There has to be a reason. It is something changing. A blood test is, for the most part, a static intervention. It's a look at a window in time. There's benefit in having a few of those over the course of a year if you're unsure about a level. So if something comes back and it doesn't look great, yeah, it might make sense just to recheck it without reacting to it. But typically, in patients, we might check blood two to four

Starting point is 00:12:34 times a year, but we're also probably doing things in there to now check, like, hey, we gave this drug that it had the desired outcome. You put on three pounds of muscle and lost three pounds of fat. Did it have the desired outcome? Speaking of tracking weight and fat lean mass percentages, is that something that you recommend your patients do pretty often? I know people that step on the scale every day. I know people like myself that might step on the scale three times a year. I don't really care. I pay attention to other things that are far more subjective.

Starting point is 00:13:10 Maybe I'm making a huge mistake. What are your thoughts about quantitative measurements of weight, BMI, for the typical person? I think they're pretty crude. I think a dexa, I'd rather take a dexa annually and then maybe follow weight a little bit more closely to get a sense of it. And so with a dexa, you're getting at least the way we look at the data, four pieces of information.

Starting point is 00:13:37 Now, most people when they do a dexa, should I explain what that is? Yeah, I think some people might not know what dexa is. In fact, I confess I have a crude understanding of what that is. I'm. Yeah, I think some people might not know what Dex is. In fact, I confess I have a crude understanding of what it is. My tell me of where I'm wrong and hopefully where I'm partly partially right. My understanding is that there are a number of different ways to measure lean mass to non-leam mass ratio. And there's one where they put you underwater. There's one where they put you into some sort of non-underwater chamber.

Starting point is 00:14:03 There's calipering. And then there's the looking in the mirror and pinching and changing the lighting. That's funny. If you've done it enough, I can tell my body fat by my abs. I can tell by how good the six pack or how bad the six pack is, what the leanness is. That's actually not a terrible way to do it. Body are, you know, a body builder, for example, which I've never been can tell you the difference between being 6%, 7%, 8%, 10%, just based on the degree

Starting point is 00:14:34 of visibility within the apps. But basically a Dexascan is an X-ray. So it's the same principle as, you know, just getting a chest X-ray where ionizing radiation is passed through the body and there's a plate behind the body that collects what comes through. And the denser the medium that the electrons are trying to go through, the less of them that are collected. So when you look at an X-ray as everybody's probably seen an X-ray, that which is white

Starting point is 00:15:01 is most dense. So if you had a piece of metal in your pocket, it would show up as a bright white thing. That's why ribs and bones show up as white. And the things that are the least dense, like the lungs where it's just air are the blackest. And everything is a shade of gray in between. So a Dexa is just doing that effectively, but it's a moving X-ray. So you lay down on a bed and it takes maybe 10 minutes and this little very low power X-ray kind of goes over your body. And the plate beneath it is collecting information that is basically allowing it to differentiate between three things. Bone mineral content, fat, other. And the other is quantified as lean body mass. So that's organs, muscles, everything else. So when most people do a dex of the, you know, they get the report back and the reports are horrible.

Starting point is 00:15:53 I've yet to see one company that can do this in a way that isn't objectively horrible. We've created our own templates. So we have our own dashboard for how we do this because we've just given up on trying to use theirs. But the first thing most people look at is what's my body fat? And this is the gold standard outside of like MRI or something that's only used for research purposes. So a DEXA is going to produce a far better estimate of body fat than calipers or buoyancy testing or things like that, provided the machinery is well calibrated and the operator knows how to use it.

Starting point is 00:16:24 I've heard some people argue that in the hands of like the guy who's been doing calipers his whole life, it could probably be comparable with calipers. But nevertheless, for an off the shelf tech, you know, Dex is amazing. You know, of the four things that get spit out of the Dexa, we think that the body fat is the least interesting. And so I would rank that as fourth on the list of what's germane to your health. The other three things that you get spit out are bone mineral density, visceral fat, and then the metrics that allow you to compute, like to basically compute what's called

Starting point is 00:16:59 appendicular lean mass index and fat free mass index. And so those three metrics are significantly more important than body fat. And the reason is as follows, right? So bone mineral density basically speaks to your risk of osteoporosis and osteopenia. And that doesn't sound very sexy to people our age, you know, 50-year-old guy is listening to this. It's like you have a big deal. But for a 50-year-old woman, it's a huge deal, right? A woman who's just about to go through menopause,

Starting point is 00:17:27 or has just gone through menopause, is at an enormous risk for osteophenia and then ultimately osteoporosis. Because estrogen is the single most important hormone in regulating bone mineral density. And we can come back and talk about why that's the case, but it's very interesting how the biomechanics of bones work and why estrogen specifically is so important. And this is a huge cause of morbidity, right?

Starting point is 00:17:52 So with your over the age of 65, and you fall and break your hip, your one year morbidity is about 30 to 40%. But again, just to put that in English, if you're 65 or older, you fall and break your hip. There's a 30 to 40 percent chance you're dead in a year. Bones matter. So we want to really get a sense of where you stack up for your age, for your sex, and if you're anywhere off the pace, we have to ramp up our strategy and be super aggressive about how to increase that or at a minimum, prevent any further decay. And are there age-related charts for the sorts of things?

Starting point is 00:18:34 Yeah, this is, this all gets spit out into what's called a Z-score. So when you're looking at your BMD, it's going to give you a Z-score. So a Z-score of zero means, and you understand this, but it's like, it's Z score referring to a probability distribution in a standard mode. So Z score of zero means you're at the 50th percentile for your agent sex, a Z score of plus one, your one standard deviation above minus one below, et cetera. There's also a T score, which is doing the same thing, but comparing you to a young person. And so the T score is technically used to make the diagnosis of osteoporosis. We tend to look more at the Z-score

Starting point is 00:19:07 and basically say, look, if your Z-score right now is minus one, in four years, I want your Z-score to be zero. Not necessarily because you've increased that entire way, but maybe you've increased slightly while it's expected that you would have declined. I see. What are some things that we can do

Starting point is 00:19:25 to improve bone mineral density at any age? So it turns out there's a real critical window in which we are malleable. So depending on the age at which someone's listening to us discuss this, you know, if you're under 2025, you are still in that time of your life when you are able to reach your potential. So it turns out that strength training is probably the single best thing you can do.

Starting point is 00:19:52 And this was a surprise to me because we did an AMA on this topic a little while ago and that's when I got really deep on this with our analysts. My assumption was a running must be the best. Like some sort of impact must be the best thing you can do. I assumed running would be better than swimming and cycling, but it turned out that powerlifting was probably the best thing you could do. And I think once you understand how bones work, it became more clear, which is powerlifting is really putting more of a shear force from the muscle via the tendon onto the bone. And that's what the bones are really sensing.

Starting point is 00:20:25 They're sensing that shear force that's being applied through the bone in a compressive way, depending on the bone, of course. And that's what's basically activating the osteoblasts, which are the cells that are allowing bone to be built. So this turns out to be probably more important for females, because how high you can get during that period of development, say, till you're 20 or 25,

Starting point is 00:20:52 basically sets your trajectory for the rest of your life. So where we get into real trouble is with patients who, for example, used large amounts of inhaled steroids during that period of their life, because let's say they had really bad asthma. For patients who needed large amounts of inhaled steroids during their period of their life, because let's say they had really bad asthma. We're patients who needed large amounts of cortical steroids for some other immune-related condition. So during their critical window of development, they were taking a drug that was impairing this process. So, you know, we have some patients like that in our practice, and that's, you know, just an enormous liability that we're working really hard to overcome, you know, with nutrition, with hormones, with drugs, with training. And, you know, it's, you know, it's just something you have to

Starting point is 00:21:30 be aware of. I wasn't aware that, um, inhalants, uh, for asthma and things that sort of can impair on mineral density. Yeah, they're steroid based. I mean, some of them, of course, are just beta agonists and they're fine. So anything corticosterone, like, yep, and then I always get asked this question, and then I always reflexively want to say no, but I don't really know the answer, so I don't reply. What about topical corticosterone?

Starting point is 00:21:55 People will put cortisone cream. To me, it seems almost inconceivable that it would have a systemic effect, but then again, what do I know? It's all dose and time related. If you're talking about, like, I've got a little rash, it's all DOS and it's all DOS and time related. So, you know, if you're talking about like, I've got a little rash under my skin, I'm gonna put, you know, corticosteroids on probably not. But certainly with enough of it put on, I mean, it is absorbed.

Starting point is 00:22:15 So it could be an issue. But that's not typically what we're concerned with. I mean, we're mostly concerned with people that are, you know, taking even modest amounts of prednisone for months, years at a time. Or like I said, kids that are using steroid inhalers for years and years and years. Again, I'm not suggesting that if you're kids on a steroid inhaler, they shouldn't be. You have to solve the most important problem, and asma is the most important problem, so be it. I think you just want to turn that into, okay, well, how much more imperative is it that

Starting point is 00:22:45 our kid is doing things that are putting a high amount of stress on their bones and via their muscles to make sure that they're in that maximal capacity to build? Do you think that somebody in their 30s or 40s or 50s could still benefit from strength training in terms of bone mineral density and longevity as it relates to bone mineral density? Given that there's this key window earlier, they might have missed that. in terms of bone mineral density and longevity as it relates to bone mineral density. Given that there's this key window earlier, they might have missed that one. Oh, yeah. No, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, 50 you plateau at 50 men start to decline, but it's really small.

Starting point is 00:23:25 Women start to decline and it's precipitous. And it's related to the drop in estrogen, the CCA with menopause or premenopause. Correct. And can we get into any of the broad contours of what that straight training looks like? We had Dr. Andy Galpin on the show. We talked a lot about ways to build strength versus hypertrophy versus endurance, etc. I think there's pretty good agreement across the fields of physiotherapy, etc., of physiology and medicine, in terms of how to do that.

Starting point is 00:23:51 But my understanding is fairly low repetition ranges. So this is anywhere from one to six repetitions, typically not aiming for a pomp hypertrophy, that sort of thing, but heavy loads that are hard to move, 80% of one repetition maximum or more done with long rest periods, two to three times a week type thing. Is that about right? If you look at the literature on this, it's going to differentiate powerlifting from weightlifting. In other words, you, you do need to be kind of moving against a very heavy load. Now again, that can look very different depending on your level of experience. Like, I really like deadlifting. Now, I mean, I can count the number of days left in my life when I'm going to want to do sets over 400 pounds, but, you know, I'll pick and

Starting point is 00:24:40 choose the days that I do, but, but, you know, I grew up doing those things. I'm comfortable with those movements. I'm comfortable with those movements. If I had a 60-year-old woman who's never lifted weights in her life, who we now have to get lifting, I mean, we could get her to deadlift, but I think I wouldn't make perfect the enemy of good. I'd be happy to put her on a leg press machine and just get her doing that. It's not as pure a movement as a deadlift, but who cares, right? We can still put her at a heavy load for her

Starting point is 00:25:08 and do so safely. So now that's sad. I mean, there was a study that was done in Australia and I'm, you know, hopefully we can find a link to it. It's, there's a video on YouTube that actually kind of has the PI sort of walking through the results. I could send it to you, Everett.

Starting point is 00:25:22 Okay. Yeah, we're right. And it's just amazing. They took a group of, you know, older women, well, thank you. And it's just amazing. They took a group of older women, they looked like they were in their 60s or 70s, who had never lifted weights in their life, who had osteopenia, and some probably already had osteoporosis, and they basically just put them

Starting point is 00:25:34 on a strength training protocol. And it is remarkable to watch these women. They're doing good mornings, they're doing deadlifts, they're picking heavy things up off the ground. I think one woman was picking up, God, I wanna say she was was picking like 50, 60 kilos up off the ground. I mean, just staggering sums of weight for these women who have never done anything. And their bone health is improving at this age. So the goal, frankly, is to just never get to the point where

Starting point is 00:26:04 you have to do this for the first time. Strength training is such an essential part of our existence. It's never too late to start, but you should never stop. Of that advice, is it a systemic effect or a local effect? For instance, let's say that my mother is in her late 70s. She actually used to be really strong when we were a kid she could move this fish tank that was in my room long before I could move it. And, um, she's really strong. Over the years, um, I wouldn't call her frail by any means,

Starting point is 00:26:35 but I certainly think she could benefit from some strength training. Let's say she were to start doing some leg presses or start even with air squats and maybe work up to some pushups. But the effects all local, meaning if she were to just train her legs or just do pushups, would it only be the loads applied to the limbs and muscles and tissues. I think that's where the bulk of it is. Okay. Yes. So you need to train the whole body, essentially.

Starting point is 00:26:59 Yeah. Now, keep in mind, the diagnosis of osteophenia and osteoporosis is based on only three locations. The left hip, the right hip, and the lumbar spine. So that's just the convention by which we make the diagnosis. And I think part of that has to do with that's where the majority of the insults occur. Now, not all of the insults. I've seen people that have, because of horrible bone density,

Starting point is 00:27:23 they're fracturing ankles and tibia fibula, like they're having low-tib, fib fractures just walking. So clearly bone density outside of those regions does matter, but much of it is really focused on, and by the way, you know, you fall, you break a wrist. So this is a systemic issue, but the majority of the response is a local response, because it really comes down to putting a load directly on that bone and then having that bone in kind respond by laying down more bone. I'd like to take a quick break and acknowledge one of our sponsors, Athletic Greens. Athletic Greens, now called AG1, is a vitamin mineral probiotic drink that covers all of your

Starting point is 00:28:03 foundational nutritional needs. I've been taking athletic greens since 2012, so I'm delighted that they're sponsoring the podcast. The reason I started taking athletic greens and the reason I still take athletic greens once or usually twice a day is that it gets to be in the probiotics that I need for gut health. Our gut is very important. It's populated by gut microbiota that communicate with the brain, the immune system, and basically all the biological systems of our body to strongly impact our immediate and long-term health. And those probiotics and athletic greens are optimal and vital for microbiotic health. In addition, athletic greens contains a number of adaptogens, vitamins, and minerals that make

Starting point is 00:28:40 sure that all of my foundational nutritional needs are met. And it tastes great. If you'd like to try athletic greens, you can go to atlettegreens.com slash huberman. And they'll give you five free travel packs that make it really easy to mix up athletic greens while you're on the road and the car on the plane, et cetera. And they'll give you a year supply of vitamin D3K2. Again, that's atlettegreens.com slash huberman to get the five free travel packs and the year supply of vitamin D3 K2. You mentioned falling and the problems with falling and breaking things and mortality related to that.

Starting point is 00:29:13 I wonder whether or not there are also health related effects of just having weak bones that are not just about falling and breaking a bone and dying a year later. Even if that's obviously very severe because I think when people hear about that, some of you might think, well, I'll just be more careful. I'll just move more slowly. I'll sit in a wheelchair if I need to, even though I might be able to walk a bit, he's sweet from falling. Some people, I think, adopt that mentality.

Starting point is 00:29:38 What are some of the benefits of having high bone mineral density for men and women that are perhaps independent of risk of injury. Well, I think it's actually the inverse of what you just said, right? It's sort of like, you have to sort of be able to articulate what it is you want in your marginal decade. So we use this thing in our practice called the marginal decade. Marginal decade is the last decade of your life. So everyone will have a marginal decade. That's the only thing I can tell you with absolute certainty.

Starting point is 00:30:07 I believe you. There's no immortality, there's no hidden elixir that's gonna help us live to be whatever. I mean, we're all gonna be in our last decade at some point. And outside of people who die suddenly or through an accident, most of us know when we're in that marginal decade. You might not know the day you enter it, but most people who are old enough, if you tell

Starting point is 00:30:29 them, are you in the last decade of your life, they probably have a sense that they are. So I think the exercise that we like to go through with our patients very early on is have them in exquisite detail, more detailed than they've ever considered. So we have to prompt them with like 50 questions, um, lay out what their marginal decade should look like. Wow. That's a serious exercise. It's a very serious exercise, right? Like what?

Starting point is 00:30:56 Tell me everything that is going to happen in your marginal decade. I don't know when it's going to be under. It could be 87 to 97 if we're doing well, right? It might be 79 to 89, I don't know, but I, you know, we would really be in a very nuanced exploration of that topic. And I think until you do that, all of this other stuff is just abstract

Starting point is 00:31:18 and kind of nonsense. You know, until a person can tell you what it is that they want to be doing in that last decade, you can't design a program to get them there. I mean, think about it. You know, someone wants to do an Iron Man, we take it for granted that we know what the objective is. I have to be able to swim two and a half miles. I have to be able to get out, take my wet suit off, hop on my bike, ride 112 miles, get off my bike, take the bike shoes off, put the run shoes on, run 206.2 miles. Like, we get it, we know my bike, take the bike shoes off, put the run shoes on,

Starting point is 00:31:45 run 206.2 miles, like we get it, we know what the objective is. And only by knowing that, can you train? Can you imagine if I said to you, Andrew, I'm going to have you do an athletic event in a year, start training. I'm not gonna tell you what it is, just do it. Could be playing basketball,

Starting point is 00:32:01 you know, it could be swimming to Catalina Island, it could be running 100 miles. You wouldn't be able to do it. So similarly, if we don't know what our marginal decade is meant to be, there's no way to train for it. Do you think this is a good exercise for anyone and everyone to do on their own, regardless of age?

Starting point is 00:32:18 Here I'm hearing this, and I'm thinking, I need to think about when my last decade might be, and what I want that to look like. Absolutely. I mean, when I say we do it and what I want that to look like. Absolutely. When I say we do it with our patients, that's only because that's the population I work with, but there's simply no reason everybody shouldn't be going through this exercise. And then you sort of back script from there to figure out what we should do and give it their current health status.

Starting point is 00:32:36 Exactly. We call it back casting. So the first step we do is once we've really delineated what the objective function looks like, we then say, okay, how do you break down that into metrics that we've really delineated what the objective function looks like, we then say, okay, how do you break down that into metrics that we can measure? So you describe doing a whole bunch of things, okay, just to let you know, to do that will require a VO2 max of 30 milliliters of oxygen per minute per kilogram. And the person will say, okay, what does that mean?

Starting point is 00:33:11 We'll say, well, that's a measure of your maximal uptake of oxygen. And that declines at about 8% to 10% per decade. So if you have to be at 30, and let's just assume you're going to be doing that at 90, so what do you need to be at 80, 70, 60, 50? Okay, here's what it would need to be at 50. Okay, what are you now? Ah, there's a big gap. You're below where you need to be now 80, 70, 60, 50. Okay, here's what it would need to be at 50. Okay, what are you now? Ah, there's a big gap. You're below where you need to be now. So you're obviously higher than 30 now, but if you're only at 42 now and you need to be at 30 and 40 years, you're not gonna cut it.

Starting point is 00:33:38 You have to be a lot fitter. Okay, now let's do the same exercise around strength and stability. And without exception, most people when they do this exercise will find out they're well below where they need to be. So the gravity of aging is more vicious than people realize, and therefore the height of your glider needs to be much higher than you think it is when you're our age. If you want to be able to do the things we probably want to be able to do when we're 90. I absolutely love this approach. I've never done it in terms of my health. I've

Starting point is 00:34:10 always thought about what I want to accomplish in the next three to six months or next year or so. And by the way, that's a great approach. That's forecasting. Forecasting is fantastic. Forecasting is really good at short-term things. It doesn't work for long-term things. Long-term you have to do backcasting. This backcasting approach really appeals to me because in my career, well, I never anticipate excuse me, I never anticipate, I'd be podcasting, but that's what I did at some point as an undergraduate I look professors and I think that looks like a pretty good life. They seem pretty happy. I talked to a few of them and then I figured out what I need to do at each stage in order

Starting point is 00:34:42 to get to that next wrong on the ladder and just kind of figured it out in a back casting kind of way as you refer to it. I think this is incredibly useful because it puts all the questions about blood work and how often to get blood work and what to measure in a really nice context that's highly individualized. I've never heard of this before. And I should give a nod to Annie Duke. I used to always refer to this as reverse engineering. But in Annie Duke's book, she wrote about this exact thing

Starting point is 00:35:10 and called it backcasting. And I was like, I like the term backcasting better. I think it's more intuitive than reverse engineering. Yeah, there's a real genius to it. And I think it, because it sets so many things into the appropriate bins and trajectories. I've heard you talk before about some of the prime movers for longevity and all-risk mortality.

Starting point is 00:35:30 I'd love for you to review a little bit of that for us. I think we all know that we shouldn't smoke because it's very likely that we'll die earlier if we smoke nicotine. I'm neither a marijuana nor a nicotine smoker, so I feel unstable ground there. But anytime we see smoking nowadays, people really want to distinguish between cannabis and nicotine. So I am curious about any differences there in terms of impact on longevity. But in that context, what are the things that anyone and everyone can do should do to live longer, basically? How long have you got? and everyone can do should do to live longer, basically.

Starting point is 00:36:05 How long have you got? Well, you tell me. You tell me. I'd like to live to be, I'd like my final decade to be between 90 and 100. Oh, no, I'm at the long, but you're getting understating. And will we spend from now until you're 90,

Starting point is 00:36:18 talking about that? Well, there's a risk of that. But top contours fine. I know you've done a lot of content on this and we will give people links to some of that more in-depth content. But let's see. So we're on a short flight from here to San Diego, if we're in Los Angeles now.

Starting point is 00:36:33 And we've got take-off in landing, and we don't want to kink our neck too much by doing this thing. So if I just said, hey, give me the extended version of the 3x5 card. What does that look like? So let's start with a couple of the thingsx5 card, what does that look like? Let's start with a couple of the things that you've already highlighted. It's just smoking. How much does smoking increase your risk of all-cause mortality? The reason we like to talk about what's called ACM or all-cause mortality is it's really

Starting point is 00:36:58 agnostic to how you die. That doesn't always make sense. If you're talking about a very specific intervention, like a anti-cancer therapeutic, you really care about cancer-specific mortality or heart-specific mortality. But when we talk about these sort of broad things, we like to talk about ACM.

Starting point is 00:37:14 So using smoking is approximately a 40% increase in the risk of ACM. What does that translate to? And that means I'm shortening my life by 40%. No, it means at any point in time there's a 40% greater risk that you're going to die relative to a non-smoker and a never-smoker. Yeah. So it's important to distinguish.

Starting point is 00:37:35 It doesn't mean your lifespan is going to be 40% less. It means at any point in time standing there your risk of death is 40% higher. And by the way, that'll catch up with you, right? At some point that catches catches a high blood pressure. It's about a 20 to 25% increase in all cause mortality. You take something really extreme like end-stage kidney disease. So these are patients that are on dialysis waiting for an organ. And again, there's a confounder there because there's what's the underlying condition that leads you to that it's you know profound hypertension, you know significant type two diabetes that's been uncontrolled, you know that's enormous that's about 175% increase in ACM. So the hazard ratio is like 2.75. Type two

Starting point is 00:38:18 diabetes is probably about a 1.25 as well. So 25% increase. So not the question is like how do you improve? So what are the things that improve those? So now here we do this by comparing low to high achievers and other metrics. So if you look at low muscle mass versus high muscle mass, what is the improvement? And it's pretty significant. It's about three X. So if you compare low muscle mass people to high muscle mass people as they age, the low muscle mass people have about a three X hazard ratio or a 200% increase in all cause mortality. Now, if you look at the data more carefully, you realize that it's probably less the muscle mass fully doing that and it's more the high association with strength.

Starting point is 00:39:03 And when you start to tease out strength, you can realize that strength could be probably three and a half X as a hazard ratio, meaning about 250% greater risk if you have low strength to high strength. High strength is the ability to move loads at 80 to 90%. So it's all defined by given studies. So the most common things that are used are actually, they're used for the purposes of experiments that make it easy to do.

Starting point is 00:39:31 I don't even think they're the best metrics. So they're usually using grip strength, leg extensions, and wall sits, squats, things like that. So how long can you sit in a squatted position at 90 degrees without support? It would be a great demonstration of quad strength, a leg extension. How much weight can you hold for how long relative to body weight, things like that? We have a whole strength program that we do with our patients.

Starting point is 00:39:57 We have something called the SMA. So it's a strength metrics assessment. And we put them through 11 tests that are really difficult. You know, like a dead hang is one of them. Like how long can you dead hang your body weight, stuff like that. So we're trying to be more granular in that insight, but tie it back to these principles.

Starting point is 00:40:14 If you look at cardio respiratory fitness, it's even more profound. So if you look at people who are in the bottom 25% for their age and sex in terms of VO2 max, and you compare them to the people that are just at the 50th to 75th percentile. You're talking about a 2x difference roughly in the risk of ACM. If you compare the bottom 25% to the top 2.5%, so you're talking about bottom quarter to the elite for a given age, you're talking about 5x,

Starting point is 00:40:49 400% difference in all-cause mortality. That's probably the single strongest association I've seen for any modifiable behavior. Incredible. So when you say elite, these are people that are running marathons that are pretty rapid clip. Not necessarily, it's just like what the VO2 max is for that like my VO2 max would be in the elite for my age group my VO2 max you know but again

Starting point is 00:41:10 It's the I'm training very deliberately to make sure that it's in that so I wouldn't consider myself elated anything anymore But I still maintain a VO2 max that is elite for my age. I can see you in elite physician and And guy all around. But true. But in terms of, OK, so for the point is, you don't have to be a world class athlete to be a lead here. Yeah. Got it.

Starting point is 00:41:35 So maybe we can talk a little bit about the specifics around the training to get into that top two tiers there because it seems that those are enormous positive effects of cardiovascular exercise. Far greater than the sorts of numbers that I see around, let's just say supplement A or supplement B. Well then B. And that's, you know, like this is my whole pet peeve in life, right? It's like I just can't get enough of the machinating and arguing about this supplement versus that supplement. And I feel like you shouldn't be having those arguments until you have your exercise house in order.

Starting point is 00:42:10 You shouldn't be arguing about this nuance of your carnivore diet versus this nuance of your paleo diet versus this nuance of your vegan diet. Like until you can deadlift your body weight for 10 reps. Like then you can come and talk about those things. There's something like, let's just go with some metrics. Like until your VO2 max is at least to the 75th percentile and you're able to dead hang for at least a minute

Starting point is 00:42:33 and you're able to wall sit for at least two. Like we could rattle off a bunch of relatively low hanging fruit. I wish there was a rule that said, like you couldn't talk about anything else. Health related. We can make that rule. No one will listen to it. Health related. Like you just... We can make that rule. And we want to listen to it. I don't know about that.

Starting point is 00:42:47 We can make whatever rules we want. We can call it a T.S. rule. But one thing I've done before in this podcast on social media is just barring from the tradition in science, which is it's inappropriate to name something after yourself unless you were a scientist before 1950. But it's totally appropriate to name things after other people's. I'm going to call it a T.S. rule. Until you can do the following things

Starting point is 00:43:06 Don't talk about something from talking about supplements and nutrition. It is here after Thought of referred to and Referenced as a Tia's rule. I coined the phrase not him. So there's no ego involved But it is now a Tia's rule watch out hashtag a Tia's rule. Oh god Wikipedia entry a Tia's rule in seriousness, and I am serious about that, dead hang for about a minute seems like a really good goal for a lot of people, at least. That's our goal.

Starting point is 00:43:33 I think we have a minute and a half is the goal for a 40 year old woman, two minutes is the goal for 40 year old man. So we adjust them up and down based on age and gender. Great. And then the wall sit, what are some numbers? We don't use a wall sit. We do as just a straight squat, air squat at 90 degrees.

Starting point is 00:43:50 And I believe two minutes is the standard for both men and women at 40. Great. And then because for some people thinking in terms of VO2 maxes a little more complicated, they might not have access to equipment or the to measure it, et cetera. What can we talk about, think about in terms of cardiovascular? So run a mile at seven minutes or last eight minutes. That's a good question. So there are really good VO2 max estimators online

Starting point is 00:44:14 and you can plug in your activity de jour. So it would be at a bike, run, or rowing machine and it can give you a sense of that. And I don't, I used to know all of those. But now that I just actually do the testing, I don't recall them, but it's exactly that line of thinking, like, can you run a mile in this time if you can your VO2 max is approximately this?

Starting point is 00:44:35 Great. And I think somewhere in my podcast realm, I've got all those charts posted of like, this is by age, by sex. This is what the VO2 max is in each of those buckets. Trivitt will provide links to those who will have our people find those links. And then you mentioned deadlifting body weight 10 times.

Starting point is 00:44:57 I just made that one up. That's not one that we include. But something like that. We use farmer carries. So we'll say for a male male you should be able to farmer carry Your body weight for I think we have two minutes So that's half your body weight in each hand You should be able to walk with that for for two minutes

Starting point is 00:45:16 For women I think we're doing 75% of body weight or something like that. Yeah, great. I love it As indirect measures of how healthy and yeah Yeah, huge yarn, how long we're gonna live. It's basically grip strength, it's mobility. I mean, again, walking with that much weight for some people initially is really hard. You know, we use different things like vertical jump, ground contact time, if you're jumping off a box, things like that.

Starting point is 00:45:38 So it's really trying to capture, and it's an evolution, right? Like I think the test is going to get only more and more involved as we get involved. because it took us about a year. Beth Lewis did the majority of the work to develop this. Beth runs our strength and stability program in the practice. And basically I just asked her with like, hey, go out to the literature and come up with all of the best

Starting point is 00:45:59 movements that we think are proxies for what you need to be like the most kick ass, you know, what we call centenary into Catholic, which is the person living in their marginal decade at the best. Well, what I'm about to say is certainly a mechanistic leap, but if you look at the literature on exercise related neurogenesis in mice or brain atrophy or brain hypertrophy, et cetera, in animal models, it's very clear that the best way to get a nervous system to atrophy, to lose neurons, shrink neurons, or lose connections between neurons is to stop that animal from moving, or to de-enrich its environment, to private of some sensory

Starting point is 00:46:37 input or multiple sensory inputs, and the best way to enhance the size of neurons, the number of connections between neurons, and maybe even the number of neurons is to enrich its environment and get it moving while enriching that environment. You know, Andrew, I think it's very difficult for me to say that the same is not true in humans. And so the first time this became clear to me was in 2014, I had an analyst, Dan Pelachar, and I said, Dan, I'm going to give you a project that is vexing me to know and which is, I want you to look at all of the literature that we have, both mechanistic and clinical trial data that talks about Alzheimer's prevention.

Starting point is 00:47:16 And I want to know every single type of input and I want to have a clear sense of via what mechanism does it offer, what what motive protection. And it took Dan, and this was obviously, we iterated a lot on this together. And he came back with kind of an amazing presentation that took all, I don't know, nine months to a year of work. And what amazed me was when he came back to it,

Starting point is 00:47:41 he said, the single greatest efficacy we can point to is exercise. And I was like, Dan, that's got to be nonsense, dude. There's no way exercise is the single best thing you can do for the brain. There has to be some drug you've missed. There has to be some other thing that you've missed. And he's like, no, like this is hands down the best thing because you're, you know, it's not just what it's doing to BDNF, it's not just what it's doing to vascular endothelium, it's not just what it's doing to glucose, disposal, insulin, insulin, all these things,

Starting point is 00:48:09 like it's just touching every aspect of the brain. And I was very skeptical for about six months, kind of really pushed on him and I was like, I think you're missing something, Dan, I think you're missing something. And then finally in the end, looped in Richard Isaacson, who's a neurologist that we work with really closely

Starting point is 00:48:24 on Alzheimer's prevention, and ultimately it turned into a paper that we wrote basically about this topic and a few others. Because again, I thought, are you sure it's not EPA and DHA? That's got to have a bigger impact. And again, there's a lot of things that I think do matter. And there's a whole host of things that we do for Alzheimer's prevention. But I think you're absolutely right. There's not one thing that I'll tell patients is more important than exercising. And by the way, it's not the sort of pathetic recommendations that are made. Like it's, you have to exercise a lot more if you want to get this maximum benefit. You will get, you know, the maximum benefit comes going from nothing to something. So if you go from being completely sedentary to doing 15 met hours per week, you'll get

Starting point is 00:49:10 probably a 50% reduction in risk. So a met hour, a met just for people who don't know, is a metabolic equivalent. So we're exerting about 1.3 met sitting here talking. If we were sitting here being quiet, it would be about one met. You know, walking really briskly would be about five bets. So 15 met hours per week would be three, one hour really brisk walks. That's not a lot of work. But just going from doing nothing to doing that would give you 50% of the benefit that you would get from going all the way.

Starting point is 00:49:44 Now again, I think I'm personally a little skeptical of how much that's, I think it's probably a bit less than that. I think there's more upside than people appreciate, but the studies I don't think can truly capture that. But look, there's no reason to not be exercising more than that and capture more benefit even though the rate at which you accrue it is less. And it also speaks to the health span side of this, which is not necessarily captured in those data.

Starting point is 00:50:11 The health span gets back to the functional piece we opened with, which is, what do you wanna be doing in your marginal decade? Do you wanna be able to pick up a great-grand kid if they come running at you? Do you wanna be able to get up off the floor? Do you wanna be able to play on the floor with a kid and then get up on your own? Yeah, and I think most people are thinking final years of life. You're going to be able to play on the floor with a kid and then get up on your own.

Starting point is 00:50:25 And I think most people are thinking, final years of life, they're trying to think, how can they take themselves to the bathroom, they're thinking, how can they sit up off the toilet? I mean, yeah, really base of vegetative type functions, right? At some level, I love this, again, this idea of marginal decade and using that as a way to backcast to actual methods and behaviors and protocols that one should be doing on a daily basis. I'll use ANIC data as it's now called to site just. I know three Nobel Prize winners, which doesn't mean anything except that they did beautiful work, but the point is that they're all in their 90s. So I'll name them because I'm complimenting them for what they've done, not just their

Starting point is 00:51:08 work, but what I'm about to describe. So Eric Kendall at Columbia, Nobel Prize-winning for work on memory, Torinson Viesel work on Neural Plasticity, and then Richard Axel, who's also at Columbia, Nobel Prize-winning work for Molecobiology of Smellin and molecular biology generally. All three of them still alive, Richards younger compared to the other two. All three of them either swim jog or play tennis or racquetball, I think is Richards thing. Multiple times per week, Eric was, they're all cognitively still extremely sharp. Still interested in the arts, doing science, curious about science, running laboratories, writing books, going on podcasts.

Starting point is 00:51:45 I mean, it's incredible. Again, that's anecdata, but I was kind of surprised to learn that colleagues that were so intellectually strong were also so obsessed with exercise. I mean, they really are obsessed with their exercise routine. And early on linked that to some of their intellectual vigor over time. I wanted to just also use that as a jumping off point to ask about one kind of niche thing, but it comes up, I don't think I'm going to out which one of those told me this, but one of those three individuals, I'm choose an excessive amount of Nicarat.

Starting point is 00:52:15 He used to be a smoker and I asked him why. And he said because in his estimation, it's protective against Parkinson's and Alzheimer's or at least the nicotinic acetylcholine augmentation of nicotine because nicotine is acetylcholine receptor, obviously, is known to create a state of focus and neural enhancement. What are your thoughts about not smoking? Let's just, as you're going to be really clear, people don't smoke nicotine, vape nicotine, it's going to shorten your life, just terrible idea, addictive, et cetera, in my opinion. But what are your thoughts about augmenting acetylcholine through the use of nicotine in

Starting point is 00:52:55 order to keep the brain healthy and focused? Again, this is one Nobel Prize winner, so it's a truly N of one. But he's so convinced that this matches up with the mechanistic data on ac Cedar Coyne and cognition that I'd love to get your thoughts on it. So I can't speak to the AD prevention component of it. I'd have to run that by a couple of my colleagues who I collaborate with on that, but I can definitely speak to the cognitive enhancement piece of it. I actually did an AMA on this probably a year ago, where I went into all of the gory details of it and talked about my own use of nicotine, which I'll cycle on and off. I've been doing it for the last

Starting point is 00:53:31 10 years. I haven't, what form do you take it in? I used to use the gum. I don't like the gum. And anymore. So now I like these little lozenges that, it's like a funny story about this. So And I'll tell you a funny story about this. So our mutual acquaintance, David Sinclair, mentioned a company to me a year ago. He's like, hey, have you heard of this company? And I forget the name of the company, but he gave me some name. So I go online and it's like this company selling nicotine.

Starting point is 00:54:00 And I'm like, I wonder why he's asking me to do this? Well, I'll just order a bunch and then we'll figure out why because we were, you know, there was some reason we were doing this potentially through an investment. So I get up, like literally ordered, like a lifetime supply of this stuff. And it's pretty good. It's actually, it's a really nice little patch because the thing I didn't like about the gum was I hated just the taste of it.

Starting point is 00:54:22 So then the next week I'm talking to David and I'm like, by the way, I ordered all that nicotine stuff you told to David and I'm like, by the way, I ordered all that nicotine stuff you told me about. He's like, what? And he goes, oh, the company's name was something else. I'm totally unruly. I'm like, God, so the short answer is, I think this stuff is absolutely a concentration, enhancing substance. It is addictive and people need to be wary of that. Now, it's not addictive to everybody. I personally experience no addiction to it whatsoever. So, I can, I could do it every day for 30 days and stop and experience no withdrawal. I could forget about it. It doesn't really seem to matter. You have to be careful with the dose, truthfully. I mean, remember, one cigarette

Starting point is 00:55:05 is about one milligram of nicotine, and a lot of these lozenges will plow four to eight milligrams into you in one shot. And for someone who is, you know, naive to that, like I am, four milligrams is a lot of nicotine in one bowl list. So you just have to be very mindful of it. I got a lot of flack when I did this AMA for obvious reasons, but people were like, how can you, as a doctor, encourage people to use nicotine? And I was like, first of all,

Starting point is 00:55:36 I'm not encouraging anybody to use it. I just want to be able to talk about the biochemistry of it. And if disclosing that I use it from time to time is an endorsement, then I apologize for that. But on the list of things that you can do to make your brain a little more focused, I would consider this infinitely safer than what a lot of people are doing, which is using stimulants.

Starting point is 00:55:57 I mean, to me, I just tell patients outright, like, we are under no circumstance prescribing stimulants. I mean, it doesn't stand. Yeah, we're just, we're not giving anybody aterol, we're not giving anybody five ants or any of these things. Not to say they don't have an inappropriate clinical use, but they should be prescribed into the care of somebody who's really monitoring the use case for it. Using that as a tool to enhance concentration and cognitive performance is not something we're comfortable doing.

Starting point is 00:56:25 Yeah, it's rampant on college campuses. I can only imagine our Modaphanoma Daffinill, which are slightly different in course, but it's a non-clinical use, not prescribed for ADHD, but just it's rampant, recreational use, study-based use. But the data I've seen on Modaphanil suggests that it only really provides a no-tropic benefit in someone who is deprived of sleep. Is there data that in a totally well-rested person, there is a no-tropic benefit of MedaFanile? I don't know.

Starting point is 00:56:53 I have one experience with Armadaphanil, where I took a half a recommended dose. This was prescribed by a doctor. I went to give a talk. This is in Hawaii. And four hours into the talk, my co-speaker came up to me and just said, well, first of all, you got a little bit of spit in the corner of your mouth, and second of all, you haven't blinked in three minutes.

Starting point is 00:57:12 And third, there's only two people left in the audience. I was so laser-ed in that I got to forgot the context. I'm a little bit of a tunnel vision OCD type anyway, but that was all it took. I never took any more of it. It was a powerful stimulant. I take 300 milligrams of alpha GPC now and again before some cognitive work, sometimes before workouts, and I do subjectively feel that Nero is my focus in a nice way, but I don't take it more than once or twice a day and more than once or twice a week. I just-

Starting point is 00:57:45 It's an example of where, you know how we're talking about exercise versus sort of nutrition and supplements for longevity. I think there may be a whole bunch of things that are kind of interesting around focus, but nothing would compare to changing our environment. Like, I think that if I compare my focus today to my focus when I was in college, there's no comparison. Like in college, I was truly a robot. But I think a large part of it was, there was no distraction. There's no email. There's no social media.

Starting point is 00:58:13 There's no internet. I mean, I was in college when Mosaic launched in the early 90s. Like I, you know, and you had to walk like a mile to get to the computer lab on a big sun workstation to do anything in some computer code language. So when you're sitting in your room studying, there was no distraction. And I think that's a far greater component of what it means to be focused than the challenges we have today.

Starting point is 00:58:38 So my thoughts on this would be, if we really wanted to return to a state of focus, we're gonna have to individually do something about our environment. And I don't know what the answer is. I've tried every little trick I can think of closing my browsers when I'm writing and stuff, but I'm just not strong enough willed. I'll pick up my phone every 20 minutes to look and see if I miss the text message or something

Starting point is 00:59:01 stupid. That's pretty infrequent. I did an episode on habits and looking at the data. It seems that people are getting interrupted or interrupting themselves about once every three minutes in the typical workplace. Now that typical has changed with a lot more people working at home. I do put my phone away when I try and work that nothing focuses me like a deadline. A bit of a fear-based urgency.

Starting point is 00:59:24 That's it. Grant deadlines. You have dropped deadlines, as I call them, or podcasts we're going to record today. That nothing works quite like it, but such is life. Well, thanks for that offshoot about nicotine. Again, you're not recommending it. I'm not recommending it, but it's clear that the augmenting the acetylcholine system, which is what nicotine does in its various forms, and some related type pharmacology does enhance focus, and pretty potently. So I think it's gonna be an interesting area

Starting point is 00:59:54 for real clinical trials and things of that sort. Love to chat about hormone therapies, and hormones generally. When Robert Sapolsky came on the podcast, we talked a little bit about menopause and the data around menopause. He's very interested in these findings that, I think I'm going to get this right, that whether or not women benefit from estrogen therapy to offset menopause really depends on when that therapy is initiated. I don't know if you're aware of those data, but he claimed that if they begin estrogen therapy in the middle to tail end of menopause, the outcomes can be

Starting point is 01:00:33 quite bad, whereas if they initiate those estrogen therapies as they enter menopause or even before menopause, then the outcomes can be quite good. I don't know what percentage of the patients you treat are male versus female and what ages those patients are, of course, but what are your thoughts about estrogen therapy for women menopause and hormone therapies generally for women maybe even testosterone therapy here about that these days and then we'll talk about men. So our practice is probably 70, 30 male female. So we have lots of women and this is a very important topic. It's also probably let me think. I just want to make sure I'm not being hyperbolic when I say this. Yeah, I don't think I am. It's hands down the biggest screw up of the entire medical field in the last 25 years. Now again, it's possible in the next hour. I'll think of, nope, there's a bigger screw-up. Another giant.

Starting point is 01:01:26 Yeah, but I don't think I will. I'm pretty confident that I won't be able to think of a bigger act of incompetence than what happened with the Women's Health Initiative in the late 90s in early 2000s, which is effectively the study that turned the entire medical field off hormone replacement therapy for women. So it's important, I think, to explain what the study looked at. So this was a study that was conducted in response to the widely held belief in the 70s and 80s

Starting point is 01:02:09 that women should be placed on hormones as they're going through menopause, right? Menopause is, I guess maybe I'll even take a step back. I don't know how much your audience is familiar with how estrogen progesterone work. Is it worth going into that stuff? Yeah, probably worth mentioning a bit of the top contour. Some of them might be familiar with it. We've done episodes on estrogen testosterone, but frankly, as I think back to those, we didn't really go into the biology of estrogen testosterone enough.

Starting point is 01:02:29 Yeah. So, I mean, actually, an interesting aside that I always tell my female patients who get a kick out of this. When you look at a woman's labs, you'll see her estrogen, her progesterone, her FSH, her LH, her testosterone, her sex andombining glib than all these things. But based on the units they're reported in, it's a very distorting picture of what the most common androgen is in her body. If you actually convert them to the same units, she has much more testosterone in her body than estrogen. Interesting.

Starting point is 01:02:59 Yeah. I did not know that. Then again, I've never been a woman getting my hormone profile down. Yeah, so even though a woman getting my hormone profile down. Yeah. So even though a woman's testosterone is much less than a man, than a man's level, it's still more than she has estrogen in her body. So phenotypically, estrogen is the hormone that's dominating.

Starting point is 01:03:17 So it's that she has much higher estrogen than a man and much lower testosterone than a man. But in absolute amounts, she has more testosterone than estrogen, just worth pointing that out. So what's happening to a woman from the age she starts menstruating until she goes through menopause, outside of pregnancy and birth control and stuff like that, is she has this cycle, roughly every 28 days, but it can vary, where at the beginning of her period, we call that day zero, her estrogen and progesterone are very low. You can't measure them. And then what happens is the estrogen level starts to rise.

Starting point is 01:03:52 And it rises in response to a hormone called follicle stimulating hormone, follicle stimulating hormone, FSH, that is getting her ready to ovulate. And she ovulates at about the midpoint of her cycle. So if we're just going to make them at easy, on day 14, she's going to release a follicle from one of her ovulate. And she ovulates at about the midpoint of her cycle. So if we're just going to make them atheasy, on day 14, she's going to release a follicle from one of her ovaries. And the estrogen level is sort of rising, rising, rising. We love to measure hormones on day five, because I want to have a standardized way in which I measure her hormones. So our women know if we're in the business of trying to understand her hormones, the day her period starts, even if it's just a day of spotting that becomes our benchmark and then day five I want to see every hormone on that day.

Starting point is 01:04:30 And if everything is going well I know what her FSH extra dial and progesterone should be on that day. So the estrogen rises starts to come down a little bit as she ovulates and then the luteinizing hormone kicks on because it's now going to prepare her uterus for the lining to accommodate a pregnancy. So now you start to see ester dial go back, but now for the first time progesterone goes up. So progesterone has been doing nothing for 14 days, and now it starts to rise. And actually progesterone is the hormone that's dominating the second half, which is called her luteal cycle. So the first 14 days is the follicular cycle, second is the hormone that's dominating the second half, which is called her luteal cycle. So the first 14 days is the follicular cycle, second is the luteal cycle. So once you get to about the halfway point of that, which is now just to do the math, 21 days in,

Starting point is 01:05:14 the body has figured out if she's pregnant or not. And again, most of the time she's not going to be pregnant. So the body says, oh, I don't need this lining that I've been preparing, I'm going to shed it. So now, progesterone and estrogen start crashing and the lining is what is being shed. And that is the men's ease. By the way, it's that last seven days of that cycle

Starting point is 01:05:34 that in a susceptible woman is what creates those PMS symptoms. So it's that actually this is something that you would probably have a better understanding of than me. There is something about this in a susceptible woman where the enormous reduction of progesterone so quickly is probably impacting something in her brain. So I think this is a legitimate thing, right? I mean, it's not like, oh, she's crazy because she's having all these PMS symptoms. No. We know that that's the case, because if you put women on progesterone for those seven days, those symptoms go away. So if you can stabilize their progesterone during the last half of their loodial phase, and

Starting point is 01:06:11 sometimes we would just do it for the entire loodial phase, just put them on a low dose of progesterone, all PMS symptoms vanish. Very interesting. I'll have to look up where the progesterone receptors are located in the brain. The Allen Brain Institute now has beautiful data of in-seat utilization, which for folks that don't understand, is looking at RNA and so where genes and proteins ought to be expressed in the human brain by using actual human brain tissue sections as opposed to just mice. So I'll take a look. I think you've been right into what that progesterone emotionality link might be and where it might exist, normal circuit-wise.

Starting point is 01:06:44 So then when the estrogen and progesterone reach their native again, that starts the cycle. So that just, that cycle is happening over and over and over again. Okay, so it became, you know, well known in the 50s that, okay, a woman's going to stop menstruating at some point. Her estrogen goes down. Why don't we just give her estrogen? Because that's clearly gonna help with some of the symptoms of menopause.

Starting point is 01:07:06 So what the women experience when they go through menopause, the first symptoms are what are called vasomotor symptoms. So this is usually in the form of night sweats, hot flashes. So, and depending on the woman, this can be really significant, right? These are women who can have a hard time sleeping. They can be having hot flashes during the middle of the day. They can wake up soaked in a pool of sweat.

Starting point is 01:07:28 Those tend to pass after a couple of years, and then they get into sort of the more long-term complications of menopause. So what we call vaginal atrophy, vaginal dryness, and then the stuff that we talked about a while ago, which is the osteophenia osteoporosis. A lot of women will complain of brain fog. So, I mean, clearly this was an issue, and it was recognized seven to years ago. Why don't we give women estrogen back to replace that hormone? And so, that went on for a couple of decades, maybe last, maybe a decade,

Starting point is 01:08:05 and then it was realized, wait a minute, we were driving up the risk of uterine cancer. And the reason for that is if you just give estrogen with no progesterone to antagonize it, you will thicken the endometrium endlessly, and you will increase the risk of hyperplasia, well, you'll definitely undergo hyperplasia and then ultimately dysplasia.

Starting point is 01:08:28 Displasia is precancerous and ultimately we were seeing that. So people figured out, well, actually, if you want to give estrogen to a woman who still has her uterus, you have to give her progesterone as well. You have to be able to have a hormone to oppose the estrogen. And then that became effectively in the 1970s, the standard for HRT. So in the early 1990s, the NIH said, look, we haven't really studied this. We have a ton of epidemiology that says giving women hormones seems to be doing really good things.

Starting point is 01:09:05 They feel better, so all their symptoms go away. They seem to have lower risk of heart disease, lower risk of cardiovascular disease, lower risk of bone fractures. Everything seems to get better, lower risk of diabetes. But we haven't tested this in a randomized perspective trial. So let's do this. So that became the WHO. And it randomized, it had two parallel arms. So it had a group for women who did not have a uterus. So these are women that had undergone history

Starting point is 01:09:37 I can be for some other reason. And then it had a group for women that did have their uterus. In the first group, there was a placebo arm and then an estrogen-only arm. And in the first group, there was a placebo arm and then an estrogen-only arm. And in the other group, there was a progesterone plus estrogen versus a placebo. Everything about the way this study was done is a bit wonky.

Starting point is 01:09:56 Some of it is justifiable, but it's important to understand. First, the women were all way outside of menopause. So none of these women were started when you would normally start HRT. And there were probably several reasons for that, but one of them is, and I think this is a legitimate reason, they wanted hard outcomes. They wanted to know death rates. And if you're doing this on women in their 50s,

Starting point is 01:10:25 you just weren't gonna get it, right? You couldn't. Yeah, you got away too long. And this was only gonna be like a seven to 10 year study. So they had to do this on women who were much older. They also disproportionately took much sicker women. I believe the prevalence, and again, I'm gonna get some of these numbers wrong

Starting point is 01:10:41 and people are gonna get all phosphorylated. But, you know, I mean, I'm in the ballpark, right? Something like 30, 40% of these women were smokers. The prevalence of obesity, diabetes was enormous. So they did, they really disproportionately picked the most unhealthy population they could that was pretty advanced in age. And again, I think part of that was to say, look, we want to make sure that after seven years, we really know if there's a difference in these causes of death.

Starting point is 01:11:07 The other thing is, this is kind of weird, although again, I understand their rationale for it, but this is a great example of, be very careful when you look at a clinical trial that it remotely represents the patients you're interested in treating. So they also treated no patients who are symptomatic. The rationale being, if we include in the study patients who are symptomatic, those who are randomized to placebo will drop out. Okay, it makes sense in terms of study design,

Starting point is 01:11:38 makes no sense if the study design is intended to mimic the real world. That's right. So now let's just keep track of the three issues. We have a disproportionately unhealthy patient population who are not symptomatic and we're starting them more than 10 years after menopause. The next thing that they did, which again, I understand why they did it,

Starting point is 01:12:00 but it's now the fourth strike against this study, is, and I've spoken with the PI of the study and asked this question point blank. I'm actually gonna have her on my podcast at some point soon to go over this in more detail, is why did you use conjugated equine estrogen, an MPA, which is a synthetic form of progesterone? Horse.

Starting point is 01:12:21 Yes. That's true. Horse, it's horse urine, it's the collect horse urine. So they're getting the it's it's a do urinate a lot or at least when they urinate it seems like a large volume of urine from what I've observed. You have a lot of experience with this. No, but you know my sister road horses were a little while my high school girlfriend had a horse and that thing. I mean the the the peas were legendary. And that thing, I mean, the peas were legendary. It's a male horse. Yeah.

Starting point is 01:12:47 So, yeah. So, the conjugate of equine estrogen is the estrogen that's collected from female horses. And then it's a synthetic progesterone. And I said to the person, I said, well, why didn't you use what we use today, which is bioidentical estrogen and progesterone? Like today, when we put women on estrogen, we use a, it's an FDA product called the Vervelle Dot. So it's a patch that you just put on and it's estridial, but it's bioidentical estridial.

Starting point is 01:13:14 And we use what's called micronized progesterone. So bioidentical progesterone. And she said, well, at the time, we just wanted to test what was currently being used. And I said, totally makes sense. But again, now you have four considerations that you have to keep in mind. Okay, so despite those four considerations, and I'm going to make a case for you why I think the MPA created a real problem in that study, the synthetic progesterone, when the preliminary results were first made available, but not yet peer reviewed and

Starting point is 01:13:47 not yet published. There was a huge fiasco, huge press announcement about it, suggesting that the women receiving the CEE plus MPA in the group with the uterus had a higher incidence of breast cancer. And that basically became the headline that never went away, though it turned out not to be true. Let's talk about the numbers. What was the increase in the risk of breast cancer in that group, which gets to my, one of my, you know, you've ever listened to me on the podcast, rail on something.

Starting point is 01:14:19 Listen, I have about 3,800 pet peeves and counting. My laboratory staff know these, know a good number of them. So you do not have to apologize for having many pet peeves. Because as long as they have experience and data to support them, it provides a better life. So one of my biggest pet peeves is, and my team knows this, because sometimes they'll occasionally, you know, they'll do this and I'll have to remind them.

Starting point is 01:14:42 You never talk about a relative risk change without an absolute risk accommodating it, right? So what does that look like? So the relative risk increase of breast cancer in the estrogen plus MPA group versus the placebo was 25, 27%. And that became the only headline. HRT increases risk of breast cancer by 27%.

Starting point is 01:15:06 Now, I don't think that's true at all today. But let's even look at the data. What was the ARR? What was the absolute risk increase? It was a difference between 5 cases per 1,000 and 4 cases per 1,000. So the ARR was 0.1% one case in a thousand. And it's true going from four in a thousand to five in a thousand is a 25% increase, but it's a completely

Starting point is 01:15:38 inappropriate context. I agree and I feel like headlines of that sort which have come up recently around various dietary interventions. We won't go there at least for not for the time being, are nothing short of criminal because they really distort people's thinking, but also they steer the course of science and medicine for, as you pointed out, for decades, if not longer. And they can really take us off our health track

Starting point is 01:16:03 in serious ways. So I'll bring this meandering to a close, which is to say, even though I could spend the next hour talking about all of the ways in which this study was flawed, and all of the very unethical things that were done by a number of the investigators who went out of their way to mask the truth of this study from the world, I'll tell a woman today, we're going to start you on this when you're going through menopause. We're using bioidentical hormones. And if your upper bound risk of breast cancer is one case in a thousand, you should at least

Starting point is 01:16:40 weigh that against all of the other benefits, which I'll talk about. Now, there's something else I want to say, because a moment ago, I alluded to the fact that I think the MPA might have been the biggest issue in that study. So, there were two findings in that study that were negative. One was the small increase in the risk of heart disease and the small increase in the risk of breast cancer. But, consider the other group. We forgot about the group that didn't have a uterus. Because remember, those women got estrogen only versus placebo. What was the difference in breast cancer there? Well, this is interesting because it didn't reach statistical significance,

Starting point is 01:17:15 but its p-value was .06 or .07. So it came very close, but it was in the opposite direction. It was a 24% risk reduction, about 1 in 1000 as well. So, when you had estrogen plus MPa, you had barely statistically significant. The p-value was 0.05, so it just hits statistical significance, 1 in 1000 cases for breast cancer, and then you had 1 in 1000 cases, but p-value of 0.07 for reduction of risk of breast cancer,

Starting point is 01:17:48 which to me suggests that the MPA, the synthetic progesterone, was playing more of a role than anything else. The second thing I point out is oral estrogen, which we no longer use, does increase coagulability. It does increase the ability of the blood to clot a little bit. And when we look at the more recent data on HRT using hopical estrogen or patches of estrogen, we don't see that at all. In fact, we see the opposite now. So now we see the risk of heart disease going down in women with estradiol.

Starting point is 01:18:19 And some women will be arriving to those treatments with mutations and things like factor five light and in other clotting factors. Is it appropriate to say that everyone, both male and female, should know whether or not they have mutant forms of factor five light? You know, we don't typically test people for factor five. My wife actually has it, but we didn't learn it until she had help syndrome giving birth to our first daughter. But, you know, we kind of look for more family history reason to be testing things like that.

Starting point is 01:18:47 We take a pretty detailed family history, so we'll kind of look for clotting issues there. What about, so your reflex nowadays is to put women on these top of the question therapy. Well, let's basically have the discussion, right? So here's where we still struggle, right, is, you know, we, if it were up to me, I'd prefer for a woman's HRT to be provided by her GYN. Because we want to be able to work in partnership with the GYN who we would like to see an endometrial ultrasound done every year. That's, you know, somewhat argued that's overkill, but, you know, we think she'd be sharing a pap smear every year as well. So if we're looking at the cervix, we want to look at the endometrium, we want to make sure the lining isn't too thick. The other thing I should say, Andrew, is today we now realize

Starting point is 01:19:31 that not all women can tolerate, pardon me, progesterone. So you have to be careful. So assuming again a woman still has her uterus, the estrogen solves most of the problems, but then you have to decide can she tolerate the progesterone? And it needs to be, if given systemically, like 100 to 200 milligrams. And for some women, that is a life-saving intervention. I mean, they start sleeping better, their hair gets thicker, they feel better, but for some women, it literally drives them crazy. It's probably the reciprocal of what we were seeing in the case of women with PMS.

Starting point is 01:20:03 So in those situations, we say great, we're done with oral progesterone, we just use a progesterone coded IUD. So then you get the local progesterone in the uterus for protection in the systemic estrogen. Fascinating. What about oral contraception for women, so the use of estrogen chronically oral contraception in women.

Starting point is 01:20:25 So the use of estrogen chronically through, you know, college years or 20s, 30s, maybe even teens who knows, what's known about the long-term effects, Fannie? I gotta be honest with you, I don't think I know enough to comment on it. It's not something that really impacts my patient population. You know, at least in what I see,

Starting point is 01:20:45 more women are using IUDs for contraception than OCs. We use OCs sometimes in women who are pre-menopausal for symptomatic control, but we'll typically use a low-low estrogen, so a very low synthetic estrogen, which I don't like using these very much, but if it's the only thing we can get to control certain symptoms and we'll use it like half per cycle. But it's typically not something we're that experienced with. What about testosterone? Because you mentioned that

Starting point is 01:21:17 nanogram per mill, when you set everything to the same, I guess it's an antigram for desolete, is it would be to kind of normalize everything. First big gram per mole. Yeah. And so what Peter was pointing out before is that you look at your charts and they're all in these different measures. And so when you normalize testosterone is actually higher than estrogen and women, that's a surprise to me.

Starting point is 01:21:42 Do you prescribe testosterone therapy to women ever? We do sometimes, but I do it with much more caution because I don't have the data, right? So where I'll, you know, what we'll say is look, I mean, we're now really outside of an area where I can point to a lot of data. Like when it comes to estrogen and progesterone, I'll happily go toe to toe with anybody

Starting point is 01:22:03 who wants to make the case that it's dangerous. Similarly, when it comes to using testosterone and men, I'll spend all day and I can go through that literature until the other person cries and wants to just call uncle, right? When it comes to... Then you prescribe them testosterone. When it comes to estrogen and testosterone and women don't have that data. I'd love to see that trial done. So what's the sweet spot? How do we reconcile that?

Starting point is 01:22:28 So it's not something I consider standard. And basically, if a woman is, if her testosterone first of all is staggeringly low, and again, even though her testosterone's low compared to a male, we still have a range. So if it's really at the bottom of that range, she's really having difficulty putting on muscle mass and really complaining of low libido,

Starting point is 01:22:46 I think in that situation, we'll go ahead and use topical testosterone. And, you know, replace her to a level that is still physiologically normal. Yeah, that's key, because when people hear HRT, they think about super physiological, seems to be the term. Yeah, like I've never seen a single symptom

Starting point is 01:23:05 in a single woman that I've put testosterone on in terms of like acne, body, hair, things like that. Like those are real symptoms that you have to be aware of, but you know, like literal enlargement and things like that. Like that doesn't happen under physiologic normal conditions. I'd love to talk a little bit about hormone replacement therapy in men.

Starting point is 01:23:26 When one looks on social media and the internet, there seems to be a younger and younger cohort of guys, people in their teens and 20s, showing up to the table thinking that injecting testosterone sippianate or taking anavar or whatever it is is going to be the right idea. There mainly seem to be focus on cosmetic effects. I'm not a physician, so I can't say whether or not they were actually hyper-ganadol, etc. But it seems to me, again, correct me if I'm wrong, but it seems to me that similar to the atia's rule as it relates to longevity, that we could come up with a broad contour rule in which if a male of any

Starting point is 01:24:02 age is not trying to get decent sleep, exercise appropriately, appropriate nutrition, minding their social connections, et cetera, et cetera, the idea of going straight to testosterone, seems like a bad idea. That said, just like with depression and antidepressants, there is a kind of a cliff after which low enough testosterone or low enough serotonin

Starting point is 01:24:26 prevents people from sleeping, exercise, social connection, et cetera. So I do want to acknowledge that. But with that in mind, how do you think about, I'm perhaps occasionally prescribed and direct to your patients in terms of hormone replacement therapy in men, percent of their thirties, percent of their forties, who's doing almost all the other things correctly. What sorts of levels do you think are meaningful because the range is tremendous in terms of what tests 300 nanograms for desoleter,

Starting point is 01:24:54 I think, on the low end now in the U.S., all the way up to 900 or 1200, that's an enormous range. What are some of the other hormones you like to look at, estrogen, DHT, and so on? So, a lot, a lot to unpack there. So let's start with the ranges, right? So the ranges you gave are for total testosterone, of course.

Starting point is 01:25:15 And we don't spend a lot of time looking at that the way we use, the way we, you know, I used to spend more time looking at total and free when I used more tricks to modulate it. So I'm actually far more simple in my manipulation of testosterone today than I was six or seven years ago. Six or seven years ago, I mean, we would use a microdose of anavar to lower SHBG in a person who had normal testosterone, but low free testosterone. What was a low dose of anabar in that context? 10 milligrams subling two to three times a week.

Starting point is 01:25:51 Anabar basically being DHT. It oxandrolone. Yeah, exactly. Exactly. And again, we're not recommending this. It's actually if you're playing a competitive sport can get you banned from that sport. No, it is.

Starting point is 01:26:01 Yeah, yeah, yeah. You can also get you banned from having children if you do it incorrectly. Yeah, so a micro dose of this has to be small enough that it doesn't impair your body's ability to make testosterone, but Anivar has such a high affinity for SHBG that it basically distracts your SHBG from binding your testosterone.

Starting point is 01:26:21 Freeing up testosterone. That's exactly right. So the goal was, how do I just give you more free testosterone? So if a patient shows up and they've got a total testosterone of 900 nanograms per desoleter, which would place them at, you know, depending on the scale you look at, the scale we look at, that would place you at about the 70th percentile. But your free testosterone is, you know, 8 nanograms per desoleter. So that's pretty bad. That means you're less than 1% free. A guy should be about 2% free tea. So that dude should be closer to 16 to 18 nanograms per deciliter.

Starting point is 01:26:56 So in that situation that I just gave you, his SHBG is really high. His SHBG is probably in the 80 to 90 range. That's very high. Because I think the upper range is somewhere around 55, 56. Exactly. So we would first backstall for what's driving his SHBG. So there's basically three hormones.

Starting point is 01:27:14 So genetics plays a huge role in this. There's no question that just out of the box, people have a different set point for SHBG. Mine is incredibly low. My SHBG is kind of in the 30s, 20s to 30s. But from a hormone perspective, there's basically three hormones that run it. So estradiol being probably the most important insulin and thiroxin. So we're going to look at all of those and decide if any of those are playing a role.

Starting point is 01:27:40 So insulin suppresses it. So this is actually the great irony of helping a person get metabolically healthy. As in the short run, you can actually lower their free testosterone all things equal. Because as insulin comes down, SHBG goes up and if testosterone hasn't gone up with it, you're lowering free testosterone. So somebody who goes on a very low carbohydrate diet and attempt to drop some water and drop some weight is going to increase their SHBG. Yeah, if the Rinsland goes behind a testosterone, less free testosterone, I can tell the carnivore diet people are going to be coming after me with bone marrow in hand. But then again, after this

Starting point is 01:28:16 discussion extends a little further, I'm sure the vegans will be coming after me with celery stalks. So it's a... So then the same as the estradiol. So except in the opposite direction. So higher estradiol is higher SHBG. So again occasionally you'll see a guy with an incredible normal testosterone, but he's a very high aromatase activity person. So he has a lot of the enzyme that converts testosterone into estradiol. You can lower estradiol a bit within a Roma taste inhibitor, and that can bring down SHBG. Now, again, these things individually are rarely enough to move the needle. The last is thiroxine.

Starting point is 01:28:52 So if you have a person whose thyroid is out of whack, you have to fix that before you, if their T4 is out of whack, you're going to interfere with SHBG. There are also some supplements, which I think you've probably talked about these on the podcast. I feel like I've heard you talk about these on the podcast. Yeah, there are a few that will adjust. There's this idea.

Starting point is 01:29:08 Now there's a much better review. It just came out. I'll send it to you. I'd love your thoughts on it. I've been cruising it line by line, but I love input. I'm experts like you on the use of Tonga Ali for reducing HPG. In my experience, it does free up some testosterone by which mechanism it isn't exactly clear

Starting point is 01:29:29 and the effects aren't that dramatic. Right, they're probably multiple effects. For all, we know it increases libido and it does generally by way of increasing estrogen slightly, which can also increase libido in some individuals. So we don't know the exact mode of action. So we've talked about a few. The one that a few years back people were claiming could reduce SHBG was stinging nettles.

Starting point is 01:29:49 Stinging nettles, well, just urine seems to be covered. Urinating seems to be coming up multiple times on this podcast for whatever reason. Stinging nettles extract, I took the most pronounced effect of that was you could basically urinate over a car. And when taking SHBG, what the underlying mechanism of that was, I do not know. I took it for a short while, it didn't drop my SHPG very much, but it did drop by DHT sufficiently, so that I stopped taking it. I do not like anything that impedes DHT. I don't care if my hairline retreats. I don't care about any of that. DHT to me is something to be hoveded and held on to

Starting point is 01:30:28 because you feel so much better when your DHT is in the appropriate range and love your thoughts on that. Yeah, I get it. It really depends on the guy and it depends on what risk you're trying to manage, right? So prostate size starts to become one of the issues with DHT. Luckily my prostate is again to genus low.

Starting point is 01:30:48 And DHT, the things that I know can reduce it are things like finasteride, propitia, things like that. Right, things that people take to try and avoid hair loss can dramatically reduce DHT and lead to all sorts of terrible sexual side effects, mood based side effects, etc. But yeah, so I'm not aware of anything that can be taken in supplement form that can really profoundly draw

Starting point is 01:31:05 Yeah, we don't spend much attention on it anymore basically I used to have a much more complicated differential diagnosis eight years ago like I I mean it was I would drive patients nuts with the whiteboard Diagrams I would draw for them when then they and I think they were just like dude just what do I need to take Today we take a much more simple approach So the first question is should you or should you have your free testosterone being hired? That's the metric I care about. Is free testosterone is the first most important, the second most important is estradiol? And sorry to interrupt you, you said, if you look at your total testosterone, you want the free T to be about 2% of your total. Well, it should be. I might not change that anymore. So in other words,

Starting point is 01:31:40 if a guy is at 1%, then I know I have to really boost his total testosterone. If he's only going to get one to one and a half percent of it, convert it to free, I need to boost him. And that's why I don't care if he's outside the range. Like I'll have a guy who's free tea. I might have to get a guy's total to you up to 1,500 to get his free tea to 18. I see. So free tea is the target.

Starting point is 01:32:00 I like to say free. And do you still use antibiotics? I'm just into trying to try and lower SHBG. I don't. Because it's too potent. is what we treat. And do you still use antibiotics, or are you central? Sorry, to try and lower SHBG. I don't. Because it's too potent. No, because it's just too complicated for patients. You know, it's a drug that can't be taken orally,

Starting point is 01:32:15 so you have to take it under the tongue. Like a trother somewhere. Right. I had one patient once who, even though we told him about 87 times that, he was like swallowing the antivars and his liver function. And he was talking 10 milligrams three times a week is a tiny dose and three months of him or whatever two months of him swallowing that every time tripled his liver

Starting point is 01:32:33 function test. So it's like, I was like, you know, it's just not worth the hassle of doing this for, you know, perfection in reality, we can fix this another way. So the first order question is, do we believe clinically you will benefit from normalizing your free testosterone? We're taking it to a level that's called it 80th to 90th percentile. So upper normal limit of physiologic ranges. That's the first order question. And that's going to come down to symptoms, and that's going to come down to some biomarkers. I think there's two years ago, maybe a year ago, very good study came out that looked at prediabetic men. You've probably talked about

Starting point is 01:33:16 this study, and looking at insulin resistance and glucose disposal within without testosterone. And the evidence was overwhelmingly clear. Testosterone improves glycemic control. Testosterone improves insulin signaling. This shouldn't be surprising, by the way, given the role muscles play as a glucose reservoir and a glucose sink. So now I include that as one of the things that we will consider as a factor for using testosterone.

Starting point is 01:33:40 Now, again, it's not the only one. So you can accomplish that with exercise, you can accomplish that with these other things. But then you get into a little bit of the vicious cycle of, will having a normalized testosterone facilitates you doing those things better. So let's just assume we come to the decision that this person is a good candidate for test osmere replacement therapy. The next question is, what's the method we're going to do it?

Starting point is 01:34:04 Are we going to do it indirectly or directly? Now, we used to use a lot of clomid in our practice. Have you talked about clomid on the podcast? I haven't talked too much about it. I'm, no, we talked a little bit about the fact that some people taking things like an AstraZol to reduce aromatics activity, run can potentially run into trouble because they think, oh, well, more testosterone good, lower estrogen bad, and then they end up with issues like joint pain, memory issues,

Starting point is 01:34:32 and severe drops in libido, and I think a lot of the reason. And even a fat accumulation. So if estrogen is too low, you can develop at a positive in a way that you would otherwise. There's a great new, new journal paper, it's probably 10 years old now that looked at, I believe it was five different doses of testosterone-sypianate.

Starting point is 01:34:49 So these men were chemically castrated and divided into 10 groups. It's pretty remarkable. Somebody signed up for this study. Yeah. So you were with and without an astrosol and five doses of testosterone. So now you basically had five testosterone levels,

Starting point is 01:35:03 plus or minus high or low estradiol. And the results were really clear that the higher your testosterone and the more your estradiol was in kind of that 30 to 50 range, the better you were. So if estrogen was too low, even in the presence of high testosterone, the outcomes were less significant. And this is 30 to 50 nanograms per decilier, not 30 to 50 percent of your ones testosterone. Okay, great. Okay, so we haven't talked, but Clomid is, you know, we have not talked a lot about Clomid,

Starting point is 01:35:32 I'd love to get your thoughts on Clomid. So Clomphine is a fertility drug. It's a synthetic hormone. It's actually two drugs, M-clomphine, and I forget the other one. And it tells the pituitary to secrete FSH and LH. So the advantage of Clomid is it's oral, and it's meant to be taken orally. So a typical starting dose would be like 50 milligrams

Starting point is 01:36:01 three times a week. And if you do that, you'll notice in most men, especially young men, FSH LH goes up, and any man the FSH and LH go up, but if a man still has testicular reserve, he'll make lots of testosterone in response to that. Because that's the first order question we're trying to answer is do you, is your failure to make testosterone central

Starting point is 01:36:24 or peripheral? Yeah, and I think just one point out, again, correct me if I'm wrong, but my understanding is that a lot of the drugs that we're talking about, the synthetic compounds, testosterone, estrogen, things related to growth hormone, et cetera, were discovered and designed in order to treat, and excuse me, in order to isolate and treat exactly these kinds of syndromes, whether or not it was the hypothalamus, the pituitary, or the target tissue, the ovaries, or the testes. Correct. Correct. Yeah. I mean, I think the easiest way to go about doing this is just give the hormone that's missing without attention to where it's where the deficiency is.

Starting point is 01:36:59 Why this becomes relevant is if you have a 35-year-old guy whose testosterone is low, is if you have a 35 year old guy who's testosterone is low, but you can demonstrate that it's low because he's not getting enough of a signal from the pituitary, why would you bother giving him more testosterone when he has the, he has the lading cells and the stritule he sells to make testosterone, he just needs the signal. Sometimes, they're not always just a course of clomid can wake him up, and he's, he's back to making normal testosterone. So he'll do this three times a week, 50 milligrams, three times a week for a short course. And then we would do it for eight to 12 weeks, and then we reevaluate. And estrogen and testosterone will increase in parallel.

Starting point is 01:37:38 Yes. And again, it depends, you know, aromatics activity is dependent on how much body fat you have and genetics. And if estradiol gets too high, we think if it gets over about 55, 60, we will give microdoses of an astrosol. But it has to be real microdoses. I mean, you cannot pound people with an astrosol to give you perspective. The sort of unlabeled use, like if you just go to a pharmacy and order an astrosol, you're

Starting point is 01:38:04 going to get one milligram tablets. Like we can't give anybody a milligram. They'll feel like garbage. We have to have it compounded at 0.1 milligrams and we might give a patient 0.1, 2 to 3 times a week. That would be a big dose of an astrozole. Yeah, I think that the typical TRT clinic out there is giving 200 milligrams per meal, one meal, 200 milligrams of testosterone once every two weeks and then hitting people with multiple milligrams of an astrosol and they're all over the place. I've never really understood.

Starting point is 01:38:35 I mean, I guess I shouldn't be surprised, but it's kind of blows my mind that these TRT clinics are up all over the place, given how bad. I mean, I see the results because I have patients that come from them, and I don't understand like why they're so incompetent. I actually think it's worse than that. I think that they simply don't understand and don't care because it's a pill mill and it's a money mill. I think that nowadays it seems almost everybody who's doing TRT is taking lower doses more frequently every other day or twice a week dividing the dose and being very, very careful with these estrogen or aromatics blockers. We, we, most of our patients do not take aromatics inhibitors.

Starting point is 01:39:11 It's not needed. It's really only the high aromatizers that need it. And so yeah, when we'll talk about testosterone, we'll talk about dosing there because I agree that more frequently you can take it the better. And frankly, you don't need to go more frequently than twice a week. Because it's so slow. Half life. Yeah, the half life of the drug is, I think it's about three and a half days, is the plasma

Starting point is 01:39:30 half life or something like that. It could be off a little bit, but twice week dosing is really nice. So if you're, if you go to testosterone clinic that's giving you 200 every two weeks, 50 twice a week is the same total dose, which by the way is a physiologic dose. That's not going to give somebody any of the side effects you would see. You're not going to get acne with that. You're not going to get kind of comastia. You're not going to get anything. The only real side effect you get from that is you will get to stickular atrophy. That is enough to suppress. Yeah, to maintain

Starting point is 01:40:02 fertility, what do you typically do for? Well, so this is where, so I'll finish the story on Clomad because we currently do not use Clomad. And that's, that's due to a really interesting observation that we, we made that I don't think has been reported in the literature yet, which is that Clomad was increasing levels of a sterile that we also happen to measure called desmosterol. I'm not familiar with that. In the way that cholesterol is made, it's made by, there's two pathways that make cholesterol. So it starts with two carbons of, it's like a cedalcoa and it kind of marches down a pathway, bifurcates, and cholesterol is the finished product of both, but in one of those pathways,

Starting point is 01:40:46 the molecule right before cholesterol is called Desmastral, and the other pathway it's called Lathosterol. So we constantly measure Lathosterol and Desmastral because we want to know how much cholesterol is being synthesized in the body, not just what your cholesterol is. We wanna know how much cholesterol you reabsorb,

Starting point is 01:41:05 and those markers are really important to us when we're looking at cardiovascular disease risk. So when we gave patients Clomid, we were noticing a almost universal rise in their Desmosterall levels. Now, the most obvious explanation for that, though the last time I looked, I couldn't find clear explanation for this in any of the clinical, like the clinical trials that

Starting point is 01:41:30 led to the approval of Clomid. So, I don't know if it was described. In fact, maybe it wasn't known. I suspect it is inhibiting the enzyme, which I think is called delta 24 desaturates that turns Desmostral into cholesterol. Makes sense if you inhibit that enzyme, you're going to see a rise in Desmastral into cholesterol. Makes sense if you inhibit that enzyme, you're gonna see a rise in Desmastral. This wouldn't have been a concern to me if not for the fact that Tom Despring,

Starting point is 01:41:51 who's one of the physicians we work with, who's one of the world's experts in lipids, pointed out a very obscure story, which was that the very first drug ever approved to treat cardiovascular disease, at least to treat hyperclestralemia, was a drug that attacked the same enzyme. So this, this was in the early 1960s, I believe, maybe the mid-60s, this drug was approved

Starting point is 01:42:15 and it lowered cholesterol. And it was approved on the basis of lowering cholesterol. Now today, no drug for ASCVD is approved on the basis of it lowering cholesterol. That's not a high enough bar. You have to reduce events. XFDs show that you're preventing heart attacks and death. But at that time, it was like, hey, at lower cholesterol, it's got to be good. Well, in the late 60s, it was pulled from the market because events were going up.

Starting point is 01:42:39 So cholesterol was coming down. Events were going up. How could that be? We don't know. What we are suspecting is that Desmastral, which is still a sterile, was potentially more damaging and created more oxidative stress in the endothelium, in the subendithelial space than cholesterol. Which would at least suggest to us, and again, we're taking a lot of leaps here that maybe having

Starting point is 01:43:05 high-dismostral, very high-dismostral is not a good thing. And so once we kind of pieced all that together a few years ago, we were like, yeah, we're just not going to prescribe climate anymore. And we then switched to HCG, which we used to use sometimes instead of climate, but it's more cumbersome to work with. It needs to be refrigerated. It's a much more fragile molecule. Yeah, I think we talked about this once. It's almost like if you accidentally knock over the little bottle, it's basically gone bad. Travel with it is very challenging. Travel with it. It's a needle. It's an injection sub-Q. So easy to administer, it's not I-M or anything like that,

Starting point is 01:43:45 but it's just more of a hassle factor. But that said, it has the benefit that Clomid does, which is it preserves testicular function, it preserves testicular volume. So, bodybuilders will often use this in their post-cycle therapy as a way to kind of recover function. And we would just use it now as ongoing therapy

Starting point is 01:44:06 for a guy who still has testicular reserve. So on its own, no testosterone, no aromatase inhibitor, nothing. Just a way to crank out a bit more testosterone from the testes, maybe some additional estrogen also. And HCG is a different model. HCG is just an analog of luteinizing hormone. So it's basically like giving them luteinizing hormone. So it's going to crush endogenous luteinizing hormone levels, right? Because it's actually... Yeah, and it... And it...

Starting point is 01:44:31 You don't really see much of an impact on LH, but you do see endogenous testosterone production go down. Actually, no, I correct that. Both FSH and LH will go down on a high enough dose. Yep. Just as I mentioned, and here I'm not making recommendations, but one supplement I've talked a lot about publicly is Fidogeogrestis, which is this weird Nigerian shrub that does on Tim's podcast on Tim's podcast and Joe's podcast. And you know, there was a bit

Starting point is 01:44:56 of a backlash because it does turn out that it high doses in rodent studies. It can cause some toxicity to the testes, but at lower doses, it does seem to increase luteinizing hormone. And after talking about this, a number of people went out there, did pre and post blood work, and the consistent effect seems to be an increase in luteinizing hormone. There's a noticeable effect on testicular size and volume, so a lot of people take them like, oh, you know, their balls are getting bigger, and so they get all excited that something good is happening.

Starting point is 01:45:24 But we don't know the long-term safety and efficacy of something like Fodogio, whether or not needs to be cycled. Yeah, this is why I'm also very leery of the supplements in this space because at least when we're using HCG, or testosterone, like we have so many years of data. You have to remember how many women are using this stuff for reproductive medicine. So I think the FDA has a lot of faults. I think I have an entire podcast devoted to the corruption of the FDA and all of the mistakes that have been made with respect to their oversight in especially generic drugs.

Starting point is 01:45:59 But it's way more regulated than the wild, wild west of nutty supplement land. Absolutely. I think that the reason for talking about things like Tonga de Fodosia was to provide some intermediate discussion between doing all the correct things but no supplementation or hormone therapy and then going straight to hormone therapy. Sort of like the leap from I can't focus very well to riddle in, right, without a real diagnosis of ADHD to, oh well, maybe some things like alpha-GPC low doses of nicotine, right? But I agree entirely. I mean, the sourcing is important.

Starting point is 01:46:33 The dosages are worked out empirically on an individual basis, and there aren't randomized control trials. They're just aren't. Yeah, and, you know, have kind of like a seven, this is another Peter principle, right? So I've got a lot of patients that come into the practice and during our intake we go through what drugs and supplements are you taking right now?

Starting point is 01:46:54 And a lot of people come in, I'm not taking anything Peter, I just, you're in charge now, like tell me what you think. And then you get a lot of people that come in and they're like, we're gonna need next a few pages for this part of the documentation. Right. People who travel with a suitcase that you can hear as they walk through the airport. Right. From all the pills, that way. And so I give these patients a little homework exercise,

Starting point is 01:47:11 which is you have to answer these seven questions for every supplement you take. And here's this spreadsheet and let's talk about it. And it basically just runs through, like, you know, it's basically walking you through the logic of why do you take this molecule. And I think for many people, when they do that, it's very sobering, right? A lot of them will come back and be like, you know what? I don't think I can come up with any reason along this really rigorous line of thinking as to why I'm taking 80% of this stuff.

Starting point is 01:47:41 Well, I know people, and actually we know someone saying people were fanatic about like red light, red light on the testes, sunning their testes, putting ice packs on their testes. It's kind of all over the place. The number of things that people are trying and doing in order to increase testosterone out, but from their testes is pretty remarkable. And that said, among some of the women I know,

Starting point is 01:48:01 the number of things that they're doing to try and promote longevity and fertility, and in particular skin health, hair health and nail health, is also kind of outrages. Everything from collagen to red light therapies, which may actually have some efficacy in certain cases, but... There's a lot... There's a lot... There's a lot... Oh, for sure. One of the things that I hope gets a lot more attention is the use of rapamycin for preserving ovarian health. So the animal literature on this is pretty impressive.

Starting point is 01:48:28 So in mouse models, rapamycin will preserve ovarian life. And so it makes sense, right? I mean, it totally makes sense why the most potent geroprotective molecule we have would also preserve and extend ovarian life, at least in mice. So I'd love to see the clinical trials done in women to test this hypothesis. I definitely want to come back to this because it's a key thing.

Starting point is 01:48:53 I know a lot of people are interested in female fertility out there including their male partners. So going back to, so now I understand why you don't prescribe clomaphym because of this this monsteral potential this monster all link What about testosterone therapy? So less frequent lower doses Less or no estrogen inhibition or a rheumatase inhibition only only a We're only using an aromatase blocker and we use a remadex when we do

Starting point is 01:49:22 It's just it's just to get that extra dial into the range we want. I like to see it between 30 and 50. That's the sweet spot. I don't know, I would say like a third, maybe not even a third. I'd say probably 20% of men require a microdose of an astrosol to get into that range, most do not. I'd rather air on the side of being a little high than a little low. So I never really want to be below 25. Unless, sometimes it's just below 25 and it is, it is what it is, that's fine. But if we're suppressing it to below 25, I never want to be in that zone.

Starting point is 01:49:58 And then yes, so TRT is ultimately giving testosterone sipionate is usually what we use. Injectible, so as opposed to cream or pellet. Correct. I used to use pellets with women for some who were really adamant about the convenience of it, but for a bunch of reasons, I'm mostly not doing that and I've never been a fan of pellets in men. You can't control the dosages once it's in there, right?

Starting point is 01:50:28 I know the dos. Yeah, that's obviously a problem. But I don't think there's a big difference when putting a pellet into a man and a woman. So when you're putting an estrogen pellet into a woman, it's like, it's that big. When you're putting enough pellets into a man for six months of testosterone, it's two sums of pellets that are longer than my finger.

Starting point is 01:50:46 So you're putting like a V shape, you're putting it into the gluteal fat. So it's just a more morbid procedure and I don't think it's necessary. I think if you know how to manage it, you know, through sort of the injections. And now, yeah, well, especially now if you're doing, you know, we're having them do sub-Q injections anyway. So it's not I am, they're using a 5-8 inch to a 1 inch 25 gauge needle, which is about the smallest needle you can push the oil through once to twice a week depending on. And by the way, if they're real needle fobs, we use Zyastead, which is a preloaded pen. And are you having all men take HCG to maintain fertility and to choose what? Oh, they have to. Got it. And by the way, we do not like to use TRT and men who, we don't like to use testosterone specifically

Starting point is 01:51:29 and men who still want to maintain fertility. We just steer them away from that. Because total sperm count goes down. Yeah, we just say why risk it? Like we'd rather use HCG. Just on its own. Yeah, just wait until you're done reproducing. Banks sperm, wait until you're done reproducing

Starting point is 01:51:42 before we go to testosterone. What are some of the benefits and what are some of the cautionary notes with appropriate TRT meaning of the kind of contour that we're talking about here. A lower dose with the yes or no low estrogen control. People, what generally people report, how do they feel, what does it allow them to do that they couldn't do or feel before, and then in terms of what are the markers to look for, is it LDL, blood pressure, water retention, acne, those kinds of things, are there some other things as well? Yeah, it depends on the doses, right? I mean, again, we're using these in really low doses, so

Starting point is 01:52:20 it's pretty rare that we'd have a patient on more than 100 milligrams a week of testosterone. I think for comparison, like a bodybuilder could easily take 500 to a thousand during a high growth phase. I know some of these guys, they go ballistic or they're doing moderate levels of testosterone, subinate, but they're also taking diandabolic sanitary-loan, you know so arms and a bunch of other things. I mean, their stacks are kind of ridiculous. I mean, not no disrespect to that sport, but I mean, people are just getting crazy in that sport right now.

Starting point is 01:52:53 It's outside of physiology. Yeah, and I get for 99% people listening, they just, they look, they hear bodybuilder and they just like, why would somebody do that anyway? Right, I think that's the typical response. So the point is a lot of, but we owe those guys a great deal of gratitude because they've shown us the boundaries.

Starting point is 01:53:08 Including the women. That's right. Yeah. Yeah. And so those bodybuilders have taught us a lot about what happens. And so, yeah, the bloating, the water retention, acne, hair loss, hair growth, all of those things, we understand the truth of it is, we just don't see those things in our patients.

Starting point is 01:53:30 But 100 milligrams per week is a very low output. My understanding is- But it's a physiologic dose, I mean, reality, but it's enough for most people. I mean, there's probably the highest we've ever had to go is maybe 70, twice a week. What's the youngest patient you've ever had to put on TRT? Actual testosterone?

Starting point is 01:53:49 Probably, I had to ask you a question, maybe 40. I think that's great for people to hear because I know that a lot of you guys in their 20s are thinking TRT is the way to go and I would argue unless you're doing everything else right and you're still hypochonadil and you're really struggling. Put that time off because also the fertility issue you wanted to lay delayed. Well, again, it depends if when we say TRT, if you're in your 20s and there's no other way, I would hope you would be steered toward HCG to at least preserve the particular function. Now, again, we don't actually know if, after being on HCG for 10 years, your pituitary will still work. You won't be able to make your own lute nines.

Starting point is 01:54:24 Exactly. So it might be the case make your own loot nights. Exactly. It might be the case that you're going to need something upstream of that, like Clomet to kickstart it. But again, I don't want anybody who's listening to this who's using Clomet for fertility to think that there's anything wrong with it. My concern over this became, if you're going to be on this for 10 years, is it problematic, not if you're using this for a course of IVF or something like that. So again, if we felt that someone's pituitary was not working, I would be happy to put three months of clomad on them to kind of try to see if we could blast it back.

Starting point is 01:54:54 Do you have men cycle on and off testosterone at these low dosages? Are they taking a month vacation from it every month? Totally depends. I was talking to a patient yesterday where we're going to do, we just decided to change a cycle, eight weeks on, then eight weeks on HCG, eight weeks on, then eight weeks on HCG. So that's going to be a cycle that maintains his testosterone level, but fluctuates between endogenous, exogenous, endogenous, exogenous, exogenous. Sometimes we'll just do testosterone on, off, on, off. And there it's like how much can he replenish naturally, but understanding his T will dip during

Starting point is 01:55:24 those off cycles. Seems to me there's a tremendous incentive for somebody to develop a molecule that can directly target SHBG besides oxygen and animal. Right? If you one could just drop SHBG just the tiniest bit, it seems like one could adjust the free tea in a way that would be great. I don't know why that molecule is so hard to target, but somebody ought to do it. The chemistry can't be that hard. Yeah, it's fine. I talked to a Patrick Arnold about this many, many years ago. I wish I could remember what his ID. He had a comment about this that at the time made sense, and I don't remember what it was, because I that thought to like, man, especially for that subset of guys who have normal testosterone, but they're just overbinding

Starting point is 01:56:10 it. I'm really glad that you brought up this issue of total testosterone versus free tea. And the reason is, ever since going on podcasts and talking about this stuff and talking about this podcast, people will send me their numbers. They'll send me their charts. And then they'll send photos of themselves. And I can tell you, while I'm not a clinician and I haven't done fancy statistics on it, there's very little correlation between someone's absolute testosterone and how they appear. Some of these guys look really lean, really strong.

Starting point is 01:56:37 And they'll say, oh, total testosterone is 550, 480. And then other people, testosterone is 860 they, you look at them and you think, oh, I kind of gav with kind of a doughy look to them. And so it's got to be this free testosterone, plus estrogen, et cetera. And so, I'm just training a nutrition too, right? I mean, I just think, I think, for all this talk about testosterone, which I enjoy talking about, and you know, I enjoy talking about the data on, you know, long-term health consequences of testosterone, because there's another controversial topic.

Starting point is 01:57:08 I also think people kind of overstate its importance. I agree. And I think there's a group of people who think if I could just fix my testosterone, everything will be better. And it's sort of like, no, actually, that's not true at all. Really, the only purpose in my mind of fixing testosterone is to give you the capacity to work harder. It's really going to help you recover more from your workouts. This should just give you a greater ability to experience muscle protein synthesis. So, if I just give you a bunch of testosterone and you sit on the couch and your nutrition doesn't change and you're not exercising anymore, you're not going to experience any benefits of this thing. I mean, my testosterone level has fluctuated quite a bit throughout my life.

Starting point is 01:57:48 And when I think about as an adult, not sort of including when I was sort of a fanatical teenager, but as an adult, when was I at my absolute most insane physique, like my best performance on a Dexascam. Would have been 38 years old. By Dexa, I was 7% body fat. My fat free mass index was like 23.2, 23.3 kilograms per meter squared. I mean, I was huge, strong, and totally ripped. My testosterone was in the toilet. I was overtra training like crazy.

Starting point is 01:58:26 I was exercising probably 26 hours a week, killing it in the gym, swimming like a banshee, cycling like my life depended on it, grossly over trained low T, but physically looked like twice the guy I am today. Today, my T's probably twice as high as it was then. So, you know, now you could say, well, Peter, what if you took T back then? How much better could you have been? Sure. But again, I think the take home is just giving somebody T doesn't do much of anything. It probably helps on the insulin resistance front without any other thing.

Starting point is 01:59:02 But to me, that's a waste. Like, that's squandering the gift that it is giving you, which is the ability to do more work and capture the benefit of it via muscle protein synthesis. I agree. And I think that the psychological effect of testosterone, whether or not exogenous or endogenous, it makes effort feel good. At some level, it really seems to do that. And so, Polky tells me the main reason, or mechanistically, the main reason that it can do that, is by adjusting levels of activity in the amygdala.

Starting point is 01:59:32 Interesting. And so there's some interesting imaging there. I'd love to chat more about the cholesterol pathway. And I know this is a huge landscape as well, but I think we're doing a good job of diving in deep, but not getting stuck in the underlying currents at all. There's tremendous debate about whether or not dietary cholesterol directly relates to

Starting point is 01:59:56 or does not relate to serum cholesterol LDL and HDL. Here's my answer. I think, well, let me put it this way. There are people that argue, I'm certainly not arguing. There are people that argue that if one eats a ton of saturated fat, that LDL goes up and HDL goes down. Oh, I thought you were okay, but that's not dietary cholesterol per se. No, not dietary cholesterol per se. But and then there are people that argue that, you know,

Starting point is 02:00:27 any increase in saturated fat intake is going to be bad that you already synthesize enough cholesterol for hormone production, et cetera. I'd like to talk about this in terms of how one should read their charts. My LDL is in what I'm told is healthy range. My HDL is in healthy range. I do try and not overeat things like butter, cheese,

Starting point is 02:00:47 and red meat, but I do eat some of those things and I feel pretty good. But most people are operating under the assumption that eating saturated fat is bad and you only do it in so far as you want to taste it. And then of course there's a small group of people that love to eat organs and meats and really pack cholesterol and would argue that doesn't matter if your LDL

Starting point is 02:01:12 is 870, it's not going to impact your health. What's the reality around LDL, HDL, dietary cholesterol, satirate fat, at least in your view. So first let's differentiate between cholesterol and fat just for the listener because we use them, you know, I don't want to make sure people understand. So cholesterol is a really complicated molecule. So it's a ringed molecule. Got, I used to know exactly what its structure was, but like it could have 36 carbons for all I remember. It is a lipid, so it is a hydrophobic molecule that is synthesized by every cell in the human body. It is so important that without it, if you look at sort of genetic conditions that impair cholesterol synthesis, depending on their severity, they can be fatal in utero. So in other words, anything that really interferes with our ability to produce

Starting point is 02:02:09 cholesterol is a threat to us as a species. And the reason for that is cholesterol makes up the cell membrane of every cell in our body. So, you know, as you know, but maybe the listeners don't, even though a cell is a spherical thing, it has to be fluid, right? It's not just a rigid, like, sphere, like a blow-up ball, right? It's got to be able to kind of move in this way to mesh with other cells. It also has to accommodate having porous structures that traverse its membrane to allow ions and things like that to go across. And it's cholesterol that gives the fluidity to that membrane. It's also as you're alluding to the backbone of some of the most important hormones in our body, estrogen, progesterone, testosterone, cortisol. So we have this thing, super important.

Starting point is 02:03:06 Okay. Then let's talk about, can you get cholesterol in your diet? Yes, you can eat foods that are rich in cholesterol. What was known in 1960, but somehow escaped everybody's imagination, until finally the American Heart Association acknowledged this a few years ago,

Starting point is 02:03:27 is that the cholesterol you eat does not really make it into your body. And the reason for that is it's a starified. So we have, and not to get too nerdy, but I think people, I think if, I really think it's important people understand how this thing works. So we have cells in our gut and enterocytes,

Starting point is 02:03:43 they're the endothelial cells of our gut. They have, each one of them has basically two transporters on them. So the first is called the NeimanPix C1-like1 transporter. The second is called the ATP binding cassette G5-G8. Okay. The NeimanPix C1-like1 transporter will bring in any sterile, cholesterol, zoosterol, phytostereol. Any sterile that fits through the door will come in. Virtually all of that is the cholesterol we produce that gets taken back to the

Starting point is 02:04:18 liver, that the liver packages in bile and secretes. So that's what aids in our digestion, which is another thing I should have mentioned earlier. In addition to using cholesterol for cell membranes and hormones, we wouldn't be able to digest our food without cholesterol because it's what makes up the bile salts. So our own cholesterol is basically recirculated in a pool throughout our body, and this is the way it gets back into the body. It's through this Neiman pixie one like one transporter. When it gets in there, the body, this is the checkpoint of regulation.

Starting point is 02:04:49 This is where the body says, do you have enough cholesterol in the body, yes or no? If yes, I will let that cholesterol make its way into the circulation. So it'll go off the basal lateral side of the cell, not the luminal side into the body. Alternatively, the body says, you know what, we have enough cholesterol. I'm going to let you poop this out. And now

Starting point is 02:05:09 the ATP binding cassette will shoot it out. It'll go back into the lumenal side and away it goes. So all of the cholesterol in our body is not as terrified. And it doesn't have that big bulky side chain attached to it. The cholesterol you eat is a starified. And an a starified cholesterol molecule simply can't physically pass through that Neiman Pixie one-like one transporter. Now, we probably manage to de-asterify 10 to 15% of our dietary cholesterol. So in other words, there are small amounts of dietary cholesterol that do make their way into our circulation. But it represents a small fraction of our total body's pool of cholesterol. Again, this was known even by Ansel Keys, the guy who turned fat into the biggest boogie man of all time,

Starting point is 02:06:00 Ansel Keys acknowledged this in the 1960s. Dietary cholesterol plays no role in serum cholesterol. Again, it took the American Heart Association another 60 years to figure that out, but even now they acknowledge that. Dietary cholesterol has no bearing. So why is it that it's pretty easy to find studies or at least people who are highly credentialed from good institutions claiming that eating saturated fat, that's different. Saturated fat, red meat, things that are rich in cholesterol, to be more specific, is bad for us

Starting point is 02:06:37 in terms of our eventual LDL. So this is two different things. So saturated fat consumption in many people will raise LDL cholesterol. So it's important to differentiate between the, what is saturated fat? So saturated fat, of course, is a fatty acid, just so people understand. Totally different molecule from cholesterol. Cholesterol is very complicated.

Starting point is 02:06:56 Ring structure, multiple rings stuck together. SFA saturated fat is just a long chain fatty acid that is fully saturated, meaning it has no double bonds and it can exist in isolation, it can exist in a triglyceride, trisoglyceride, or a phospholipid or all sorts of things like that. So when we eat foods that contain fat, basically there are three distinctions for that fat. Is it saturated? Is it mono unsaturated, one double bond, or is it polyunsaturated, two or more double bonds? The observation that eating saturated fat raises cholesterol is generally correct. But again, now it makes,

Starting point is 02:07:37 because if we're gonna start talking about LDL, we have to explain what LDL is. This is another one of those things that's just so grossly misunderstood that it makes having discussions about this very complicated. Let's go back to the cholesterol problem. Every cell in our body makes cholesterol. Almost without exception, they make enough. There are a handful of times, however, when a cell needs to borrow cholesterol from another cell.

Starting point is 02:08:07 Okay, so how would you do this, right? So if you're sort of, if you're playing God for a minute and you wanna design a system, you have to be able to transport cholesterol from one cell to another. The most logical place you would transport this is through the circulation.

Starting point is 02:08:24 And the problem with circulation is its water. Plasma is water. So now you have this problem, which is I want to transport cargo that is hydrophobic in a hydrophilic medium. Can't do it. So if you think about all the things that we transport in our blood, sodium, electrolytes, glucose, things like that, they're water soluble. It's easy, they just move back and forth

Starting point is 02:08:49 in our blood with no shaperone. But when you want to move cholesterol, you have to package it in something that's hydrophilic. That's something is called a lipoprotein. So we have these spherical molecules that are lipid on the inside, protein on the outside, lipoprotein. And inside, they contain cholesterol and triglycerides.

Starting point is 02:09:09 So now you've got this spherical thing, triglyceride, cholesterol on the inside, and it's shaperoned by a hydrophilic molecule that allows it to move through our circulation. And those lipoproteins exist in different densities. So if you run these out on a gel electrophoresis plate, you'll identify different densities. The density is a function of how much protein and how much lipid is in it. So the highest density of this

Starting point is 02:09:36 is called a high density lipoprotein. And the lowest density of this is called a very low density lipoprotein, a VLDL. And then next to that, you have an LDL, a low density lipoprLDL. And then next to that, you have an LDL, a low density lipoprotein. And then next to that, you have an ideal, an intermediate density lipoprotein. So, you know, it actually goes VLDL,

Starting point is 02:09:57 ideal, ideal, but anyway. So, when people say my LDL is high, or my LDL is 100, what are they saying? They're saying the cholesterol concentration of my LDL particles is 100 milligrams per desoleter. So the total cholesterol concentration you have in your circulation is that number that says total cholesterol. So if someone's blood panel says my total cholesterol is 200, it means that if you take all the

Starting point is 02:10:23 lipoproteins in their circulation, bust them open and measure the cholesterol content. It's 200 milligrams per desoleter. And for all intents and purposes, because the IDLs are so short-lived, that's basically the sum of your LDL cholesterol, your VLDL cholesterol, and your HDL cholesterol. Those three things, sum to your total cholesterol. What about LDL, little A that you mentioned earlier? LP, little A is another, yeah, he's another actor.

Starting point is 02:10:48 He is a special type of LDL that, again, in sort of 10 to 20% of the population is a really bad actor. So that's an LDL that has another apolipoprotein on it called apolipoprotein, little A. The other thing I'll just say on this because earlier I mentioned ApoB, there are two broad protein on it called apolipoprotein little A. Got it. The other thing I'll just say on this because earlier I mentioned apob, there are two broad families of lipoproteins. There are those that are wrapped in apob and those that are wrapped in apoAs. The apoA family is the HDL family.

Starting point is 02:11:18 The apob family is the VLDL, IDL, LDL family. I see. So for somebody who, let's say their total cholesterol is, let's just stay with 200 or simplicity, what do you like to see in terms of the HDL LDL ratio? Couldn't care less. I only care about APOB. I only care about APOB.

Starting point is 02:11:39 I care about the causative agent of atherosclerosis. APOB is the thing that drives atherosclerosis. What levels are attractive or repulsive for you? When you see levels of APOB that are blank, you get really concerned. What depends on the person's objectives. So again, we take a very different view. I mean, we have vitality now, lived now, and I want to live to be 100.

Starting point is 02:12:06 Yeah. So if you're assuming some taper, if you tell me you want to live to be 100, you're going to need to keep your ApoB below 30 milligrams per deciliter. Let's say I want to live to be 100, but I also, well, how about I don't care how long I live, but I want to feel great while I live. Again, it depends, right? Anybody who's had a heart attack is going to be compromised in their ability to feel well after, right? So I guess I make say it that way because if you're going to tell me that I'm in order to achieve that, live to a hundred level, I'm going to have to give up my personal life

Starting point is 02:12:41 and my brain functioning, then I'm not really interested in it Sure, but but to get LDL levels and really again people think of it as LDL It's really a bobe right a bobe is this total concentration of LDL and V LDL and that's what matters Those are the big atherogenic particles LDL also includes the the LPLidl A although the concentration of LPLidl A is relatively speaking so small that it doesn't generally show up as much in the APOB. So we treat APOB, and basically what it comes down to is you want APOB to be as close to the level

Starting point is 02:13:14 as it was when you were born. So we start developing heart disease when we're born. That's just the way it is. The autopsy studies make this abundantly clear. When you look at autopopsies of young people who are dying in their 20s, and this was first done in the 1970s, it was again repeated. Again, it's always done after we have a war, right? So in the 1970s, it was done on people who died in Vietnam. In the early 2000s, it was done on mostly young men, but some young women who were,

Starting point is 02:13:41 you know, dying in Iraq and Afghanistan. And we saw without any ambiguity that cardiovascular disease is already taking hold in people who are 18, 19, 20 years old. And to be clear, they aren't going to die of atherosclerosis at that age. There's still 40, 50 years away from it, but this is a lifelong disease. And we also know that the disease can't really develop until APOB reaches a certain threshold. And that's the threshold that most of us get to by the time we're sort of in our teens. So it's this really young APOB level of kind of 20 to 30 milligrams per deciliter that makes it impossible to get atherosclerosis. So APOB is necessary, but not sufficient to develop ASCVD.

Starting point is 02:14:25 Now, go ahead. Oh, I'm sorry. I was just going to ask, what are some of the top behavioral, nutritional, supplementation, if any, based, and prescription drug-based ways to target APOB? Well, nutritionally, you basically have two big tools, right? And it depends on what's driving up APOB. So, APOB, remember, is the concentration of LDL and VLDL particles. And what do they carry? Collestral and triglycerides. So anything that reduces cholesterol and reduces triglycerides is going to reduce APOB. Triglycerides are generally driven by carbohydrate intake. So more insulin resistance,

Starting point is 02:15:07 more carbohydrate intake, more triglycerides. So we, I mean, clinically, this is readily apparent to anyone who treats patients. If you restrict carbohydrates, you will reduce triglycerides. That just happens all day long. But if you reduce triglycerides by raising fat intake so much, it can still raise APOB. So you have to be able to think about it. So in an ideal world, can you lower saturated fat, which tends to be the one that is most driving APOB while lowering carbohydrate and then see what you can get? But here's the reality it is.

Starting point is 02:15:41 There's nobody with dietary intervention that's going to get to a level of 30 milligrams per deciliter. I mean, I've never seen any of these. Pure dietary intervention. Yeah. So what are the other things that you can do? It's going to be pharmacologic at this point. Statentype interventions. Well, now you have multiple classes of drugs.

Starting point is 02:15:54 So the tried and true is the statin. So statins work by inhibiting cholesterol synthesis. And the net effect of that is that the, so the liver is really sensitive to cholesterol levels. It doesn't want too much, it doesn't want too little. When you inhibit cholesterol synthesis, the liver says, I want more cholesterol. It puts more LDL receptors on its surface and it pulls the LDL out of circulation. That's what lowers the LDL in the circulation. So, you know, again, nine statins in use today, we typically use four of them.

Starting point is 02:16:29 The side effect profile contrary to kind of all the sort of statin-hating propaganda out there, very benign, right? Five percent of people experience muscle soreness, which reverses upon cessation. Cognitive effects. Again, I think it's, in terms of actual comparing it in a placebo, no effect whatsoever, right? So does that mean that you put a patient on it, they won't complain of something? No, but if you look at clinical trials, there's no evidence whatsoever

Starting point is 02:16:58 that's datensin pair cognition. There's also no evidence in clinical trials that they accelerate the risk of neurodegenerative disease. In fact, it's the opposite. Now we, there's a very nuanced case we make, There's also no evidence in clinical trials that they accelerate the risk of neurodegenerative disease. In fact, it's the opposite. Now, there's a very nuanced case we make, Andrew, which is we'll look at patients with highly suppressed desmostral levels. We will back off.

Starting point is 02:17:16 We do want to maintain desmostral above a certain level because of some evidence that is still I think very preliminary, but enough for us that we say, why take the chance? We have so many other tools to lower cholesterol. Why would we over-suppress synthesis in a susceptible individual? So the next tool you look at is a drug that blocks the absorption or the reabsorption of cholesterol. Remember that Neiman pixie one-like one, transporter? So that guy has a drug called

Starting point is 02:17:46 azetamide that just mechanically blocks it. So in people, and that's why I mentioned earlier, we measure all those steriles in people. So we also measure things called phytosterols, and the phytosterols give us an indication of how active that transporter is. So the higher your phytosterols, the more likely you are to respond to Zetamog. Next class of drugs is a drug that blocks cholesterol synthesis, but only in the liver. So the statin does it globally. This other drug called Bempidoc acid does it only in the liver. So it has a very similar mechanism to statins, different enzyme.

Starting point is 02:18:20 Not quite as potent, but way fewer side effects. So any patient that's having a response to statins that's adverse, we'll try this other thing. What's it called one more time? Benpidoc acid. Benpidoc acid. The most potent drug of the lot is the PCSK9 inhibitor. So PCSK9, it's a protein that was discovered

Starting point is 02:18:37 in the late 90s, I believe, is responsible for the degradation of LDL receptors. This was first discovered in people who had a condition called familial hypercholestralemia. is responsible for the degradation of LDL receptors. This was first discovered in people who had a condition called familial hypercholestralemia or FH. So these people that have incredibly high cholesterol. Typically, their total cholesterol level is 300. Their LDL cholesterol is typically north of 200 milligrams per deciliter.

Starting point is 02:19:02 This is a disease that is defined by the phenotype, not the genotype. So the phenotype has a very clear definition, which I basically just gave you. The genotype is there's a million paths to get there. There's over 3,000 mutations that are known to produce that phenotype. This was discovered to be one of them. In people who had hyper functioning PCSK9, this protein was just constantly hammering and destroying the LDL receptors, and so their LDL would be huge. And by extension, their total cholesterol would be. So in 2006, Helen Hobbes and colleagues discovered an opposite group of population, people who had LDL cholesterol naturally of 10 to 20 milligrams per desoliter,

Starting point is 02:19:46 which would be an APOB of about 20 milligrams per desoliter, and who never got heart disease. They were immune to heart disease, no matter how long they live, and they had the opposite. They had hypofunctioning PCSK9. And so that was 2006 in England Journal of Medicine. That basically got a whole bunch of drug companies hot on the trail of producing a drug to mimic it. So now we have these antibodies, and they're wildly effective. What percentage of your patients over 45 do you have on either a statin or on one of these other classrooms?

Starting point is 02:20:17 Well, often it's in combinations, and I would say 80%. 80%? We have to remember what our objective is. Like, we're in the business of trying to make sure people live as long as possible. And you have to take a sort of world view of this, right? If you, like, what's the most prevalent cause of death globally? It's a cardiovascular disease. And, like, how close is it?

Starting point is 02:20:37 So the last year before COVID, COVID kind of messes up these numbers a little bit, but if you go to 2019, 18.6 million people died of heart disease. Number two, cancer, 10 million. Like, nothing's in the zip code of atherosclerosis. And if you remember what I just said, if you had, if you took everybody in their 20s and reduced them to a level of that of a child, you'd make AACVD and orphan disease. So, the question is, why don't we hear more about this? I realize there's some nuance.

Starting point is 02:21:14 It's not straightforward. It's not as simple as saying eat less cheese, red meat, and watch your LDL, get on a statin. But why do we hear so little about APOB in the general discussion? Social media is such a skewed landscape as we know. People shouting into tunnels of varying clarity, you know, some are beautiful bronze tunnels with clean walls and others are sewer lines, right? And they all converge in the same place, as we know.

Starting point is 02:21:47 But why do we hear so little about this? I mean, I'm not on a statin, but now I'm beginning to think that maybe that might be a good idea to consider one of these other compounds. I don't know the last time I looked at my APOB specifically, I'm guessing my physician did, but why don't we hear more about this? This is, this sounds so important. It sounds like the most important conversation because all the hormone stuff and all the stuff about

Starting point is 02:22:10 smoking and head injuries and ADHD and all the rest, I mean, is irrelevant if you're dead. Right? Yeah. It's a good question. I don't think I have a great insight as to why this isn't more front and center. I think the bigger problem is why don't we even understand how to think about it?

Starting point is 02:22:28 I mean, the, the, and there's a whole chapter in my book I'm working on that really gets to this problem of why, why aren't we looking at atherosclerosis in terms of treating the causative agent. Instead, we look at modifying 10-year risk. So that's the fundamental difference between what I call medicine 2.0 and medicine 3.0. Medicine 2.0, which is what we're generally practicing today. When it comes to ASCBD, he says, look, we will treat you. We will lower that LDL cholesterol. They still don't talk about APOB, but that's a very American thing.

Starting point is 02:22:59 If you go outside of the United States, everybody's talking about APOB. It's in the guidelines in Europe and Canada everywhere else. The United States is very stubborn on this and it's due to a couple of really weird personalities in the lipid world. But the paradigm is when your 10-year risk reaches 5%, and there's a 5% chance that you're going to have a heart attack stroke or die in the next 10 years. Now it's time to treat you. Medicine 3.0 says, that's not the way to think about it. You treat the causative agent.

Starting point is 02:23:33 If there's a causative agent, you treat it. If blood pressure raises the risk of heart disease, you lower blood pressure. If smoking raises the risk of something you treat smoking. And the reason that the risk model is so bad when you're looking at 10-year risk is age is the biggest drive-rive risk. I mean, bar none, right? So if you take a 70-year-old with perfect lipids and perfect blood pressure and perfect everything, their 10-year risk of AACVD is probably 4 to 5 times higher than the most unhealthy 30-year-old. It's not even close. There's a lot like eye disease. There are exceptions, of course.

Starting point is 02:24:14 We always say that the biggest risk factor for going blind from glaucoma is being an older person. Frankly, you know. So if you could identify what the risk factors are for glaucoma, imagine if the paradigm was, we're only going to treat it when your risk of blindness reaches 5%, which isn't triggered until you're old enough. Anyway, wouldn't you rather know that when you're 30 and say, wait, if maybe being in the sun without sunglasses or using this type of eyedrop or something like that has a negative impact, I would rather know that sooner.

Starting point is 02:24:45 So that's the fundamental difference. It's a philosophical difference with respect to prevention. And I will acknowledge that in one element of prevention, I make no consideration. I am only coming at this through the lens of the individual. I am never coming at this through the lens of society. That makes my life easier and it makes the problem I'm solving easier. I don't have to answer the quality adjusted life year problem. I don't have to ask the question, is it economical to treat people at 30? I don't know the answer to that question, but I also know that when you're trying to

Starting point is 02:25:20 solve really complicated problems, the more you can simplify the better. So I've just acknowledged openly, not solving that. If you want to criticize me for it, that's fine. Let's be transparent. But all I care about is the person I'm sitting across from. And in that situation, it's really their decision if they can justify the cost of treatment. An esoteric question and then a less esoteric question. The esoteric question relates to something that I think is a little bit niche, but not necessarily so, which is peptides and stem cells in PRP. I don't want to go off on too much of a tangent on rehab, but I know you've done a number of posts on social media recently that were, I have to just tell you, you're really thoughtful and I really appreciate that you're willing to share your own tissue rehabilitation experience

Starting point is 02:26:03 and point people that because this is a landscape that a lot of people are in and they don't know how to navigate it and a mutual friend of ours not to be named sent me a text and said I'm going to be talking to a teah and what do you know about studies on things like BPC 157 is gastric peptide that anecdotally again anecdot, people report getting injections of this into shoulder knee, et cetera, and feeling so much better, so much faster, but there really aren't good studies, controlled studies. And you hear all the same sorts of things about platelet-rich plasma, PRP, which if someone tells you there are a lot of stem cells in them, they're lying, there are not a lot of stem cells in them. And you hear also hear about stem cells, which are not FDA approved, at least in

Starting point is 02:26:47 this, you know, for most uses in this country, but are certainly people are flying down to Columbia and getting injections. And what is your understanding or experience with things like BPC 157, specifically, because peptides is a huge landscape, we should probably do a whole episode of peptides, things like PRP. PRP is now approved for, I mean, women are getting injections of this into their ovaries to improve follicle count.

Starting point is 02:27:10 We know this. People are getting injections of PRP into every tissue and organ, and it's how men are getting injected in their penis. So I hear for all sorts of reasons that are unclear to me. What's the deal with PRP, BPC157 and STEM cells? Do you ever see interesting effects? Are you curious about these compounds?

Starting point is 02:27:32 Do you prescribe or direct people towards these? The FDA approved ones of course. Yeah, so short answer is I'm definitely curious about them and I'd love to see the work done, but I also think this is about as wild, wild west as it gets. PRP less so, but certainly stem cells and peptides. And I just think if you're going to do something without a clinical trial, you've got to show up with a lot more data.

Starting point is 02:27:57 So let's use rapamycin as an example. I'm a huge proponent of rapamycin, and you can say, well, Peter, how can you take or prescribe rapamycin for zero protective effects when we do not have a human clinical trial demonstrating that it lengthens life? And the answer is, because I have 84 other pieces of data that all point in the same direction across every model organism going back more than a billion years. model organism going back more than a billion years. And that's really different from Joey, Sammy, and Sally did this thing, and I think it works. And they just can't be compared. Now, I have no idea if stem cells work. I have no idea if BPC157 works. I have no idea, frankly, if PRP even works, though it might seem to have

Starting point is 02:28:45 some efficacy and some indications. For example, maybe when it comes to early hair loss, maybe when it comes to certain joint issues. But the reality of it is, I think we just have to accept the fact that everything we do has an opportunity cost. And that opportunity cost is sometimes financial, but I actually find a lot of times it's in time and effort and energy that goes into something. Now, when I was, you know, waiting to get my shoulder surgery, this is an injury that I've had forever, right? This is an injury, you know, I've,

Starting point is 02:29:20 I, this, this injury was actually probably the greatest source of discomfort I had swimming, the Catalina channel the last time in 2009. So that's, that tells you how long I've had this injury. Um, but, you know, I sort of knew at some point, like, I'm going to have to have it fixed. And I sort of went down this rabbit hole, like, Hey, is there anything I can do to avoid having surgery, you know, would, would infusing a million stem cells into it work? Um, and in speaking with as many orthopedic surgeons as I could,

Starting point is 02:29:47 the answer was kind of unambiguously now. And by the way, it doesn't mean you wouldn't feel better if I injected a bunch of stem cells into your shoulder. There are a lot of reasons that might make you feel better, just like there are a bunch of reasons you can feel better if somebody inject sailing directly into your joint. So, so the question is, is it going to fix the underlying problem? And if so, will it do so by what mechanism? So I'm pretty sure that if you took a thousand people with my particular injury and injected them with stem cells, it wouldn't do a thing.

Starting point is 02:30:17 Because of the nature of my injury, I had a complete laboral tear. Are there some injuries that might benefit from it? Yeah, possible. So the question is how would you design the trial to narrow down your patient population correctly so that you might see a signal? Because the other risk of doing a trial is you have too much of a heterogeneous patient population. You don't know what the heck you're really doing and you get meaningless results. You get a null result when in fact there's a small signal but you were underpowered to pick it up because you only had 10% of your patient population that was the right patient population

Starting point is 02:30:53 to get that. Will we ever get there? I don't know because I don't see what the incentive is. You have people who are making money handover fist doing procedures on the basis of, I'm not sure what, what would their motivation are incentive be to sort of see this legitimized? You'd really have to be able to say, well, there really needs to be sort of a pharma angle to this.

Starting point is 02:31:18 It's sort of one of the wishes I had, right? Like if I was a billionaire, I feel like, the way I would probably waste all of my money would be running clinical trials on stuff nobody cared about. Yeah. If it just by, likewise, I would join you because that would be yesterday we recorded a sit-down with somebody from Caltech who works on aggression and rage and think and other things related to that and has identified peptides that are approved the FDA for other reasons that seem to adjust anxiety might even adjust aggression and pathologic

Starting point is 02:31:50 aggression and went off on to a long description of why none of these drugs exist on the market for the treatment of psychiatric illness and yet probably would work. And what's missing is a billionaire or a billion dollar company that is willing to invest in something that very likely will work, but the market value isn't quite there. Or it failed in a previous trial, and so no one wants to touch you with a 10-foot pole. Hopefully someone listening to this will be incentivized to provide this sort of venue for that, the kind of work that we're talking about. I have to ask. But I want to make one other point, Andrew, which is, to me, the problem with a lot of these

Starting point is 02:32:31 things is it gets, it's a crutch. It's sort of like what we talked about with, like, hey, just fix my team, man, and everything's going to be fine. And it's like, no, that's just the beginning. What I worry about when I see people who are clamoring for this stuff is a lot of times they don't realize that whether it's psychologically or otherwise, they sort of say, well, now that I've had this thing done, I don't have to do the hard work

Starting point is 02:32:53 of the real rehab. I mean, if I've learned anything through my shoulder surgery and I'm now three and a half months out. How does it feel? Amazing. I mean, look, I still can't do a lot of stuff. It's gonna be, you know, a while, I haven't even been able to shoot a bow yet,

Starting point is 02:33:05 and it'll probably be a year before I'll go back to, you know, long dead hangs and heavy dead lifts. I mean, I don't know, maybe nine months, but it's, you know, I'm not there yet. But what I learned through a really amazing prehab and rehab process is, like, you just gotta do the work. And it's freaking hard.

Starting point is 02:33:26 Shoulders are the most tedious boring thing in the world. I mean, three days a week, I am doing four days a week, I am doing one hour of just dedicated stuff for this shoulder that is super, just super uncomfortable, super boring, super frustrating, but I mean, I have faith in the methodology, right? And I think a lot of people are saying, just shoot the stem cells into me, and I don't have to do any of that stuff.

Starting point is 02:33:55 And the reality of it is, I think that's a very dangerous place to be. Have you ever tried BPC 157? Yeah, we tried it We had you know again, maybe seven eight years ago. We had a bunch of patients ask about it So you know my view is okay. I was pretty convinced that there was no safety downside to it So I was like well, I wouldn't prescribe it to a patient unless I tried it myself So me and another doc in the practice Ralph we did it for I don't know a couple months. I didn't notice a single thing

Starting point is 02:34:25 Interesting in the practice Ralph, we did it for, I don't know, a couple of months. I didn't notice a single thing. Interesting. Well, thank you for that. Shifting to a less esoteric, but, and I think probably more important topic overall, metabolomics, talking about this before we set down the record. What is, what are metabolomics? Why should we be thinking about them?

Starting point is 02:34:44 I have some idea of what it might be about, but most people I think are not thinking about metabolomics at all, and for those that are, I'm sure they could learn more. So tell us about metabolomics and what you'd like to see more of in the world of metabolomics. Yeah, so omics is just the term that we use

Starting point is 02:35:01 to describe this study of something. So genomics, right, is like the broad study of genes and, you know, proteomics, the broad study of proteins and things like that. So, so, Metabolomics is just study of metabolites. And metabolites, unlike a lot of these other things, they're relatively finite number of these things. Many of which are known, but some of which are not known. So, glucose is a metabolite. The CylCoA is a metabolite known. So glucose is a metabolite. The Cedal CoA is a metabolite.

Starting point is 02:35:25 Lactate is a metabolite. And so the question is, what do we know about these things and how they work? And more importantly, what do we know about certain physiologic states and the metabolomic profile that results from them? So let's use two extreme examples, like exercise. Everybody understands the data are unambiguously clear. Exercise produces about the most favorable phenotype imaginable.

Starting point is 02:35:55 So if you wanted to take a genomics approach to understanding that you might look at, is there a change in the genome when you exercise? The answer is probably not, but maybe if you looked at the methylation patterns in epigenome, you could look at epigenomic studies. But you might instead look at the proteome side of that. What is gene expression doing? And there you would see a lot of changes. Well, what I don't think people are really understanding, although there was a very interesting paper that just came out two weeks ago that looks for novel metabolites that are changing. There was a huge signal in a metabolomic profile that looks different in the state of exercise

Starting point is 02:36:38 versus non-exercise. And could that represent part of how exercise is transmitting its benefit through the body? You know, people always talk about the Holy Grail of Metabolomics would be, can you find pill to mimic exercise? And I think the answer to that question is going to be undoubtedly no. For a couple of reasons. One, even if you could mimic the longevity sort of lifespan parts of it, you could never mimic the health span parts of it. But what if you could do both, right? What if there were small molecules

Starting point is 02:37:10 that can replicate some of the protective benefits of exercise and you could combine those with exercise? What if those could be treatments for other disease states like diabetes, things like that? So that's why I think this field of metabolomics is relatively untapped, and I think potentially the next frontier. Speaking of frontiers, I hear a lot nowadays about GLP1 and pharmacology, that prescription

Starting point is 02:37:36 drugs that mimic or increase GLP1 directly, Google on like peptide. People are talking about this as the blockbuster obesity drug. I haven't heard this much talk about a drug to adjust human body weight favorably since the discussions of FENFEN when I was in college and then of course FENFEN was pulled from the market because people were dying, not left and right, but enough people died that they pulled it from the market. Which by the way is an interesting story. It was the enantimer that they chose to use that was the wrong enantimer.

Starting point is 02:38:10 What it resulted in was, God, I think it was like... So, mitral valve. Yeah, it was like... It was an MVP, yeah. It was something in the mitral valve. Yeah, I think the cordate tendon A were rupturing in the mitral valve. It was mostly young women, I think, were getting horrible pulmonary diseases, a result of it, probably pulmonary hypertension or something like that.

Starting point is 02:38:32 But there were two enantiomers of the drug, and they just used the other one. This issue wouldn't have happened, and there was a stupid reason why they made the choice to use the one they did. And it's one of those things where once you make the mistake, you're never going back. It's not like that company could say, okay where once you make the mistake, you're never going back. It's not like that company could say, okay, we wanna do over, but we're gonna do it with the right version. So it's a tragic outcome.

Starting point is 02:38:52 But, but you're absolutely right. I think the GLP1 agonists have more efficacy and for all intensity and for everything we can see, certainly seem safer. Are you excited about them? Yeah, I am. I think we're just seeing the kind of tip of the iceberg. They're not miracle drugs, right?

Starting point is 02:39:10 They come with problems, right? Which is, you know, they're catabolic across the board. So patients are losing fat, but they're losing muscle as well. So, you know. You just sent all the Jim Jockey's running from some of Glutinantall. That's all you have to say. All you have to say nowadays about something is that

Starting point is 02:39:28 it's gonna drop testosterone, lower fertility, change someone's skin hair nails, and it's like people, it could extend life to being 250 years old and people are gone. Humans are human. That's a neuroscience and psychology issue, not a biology medicine issue.

Starting point is 02:39:45 But I'm pleased to hear that you're excited by them because I hear a lot of excitement. I haven't heard anything disastrous about them. It takes a while to get people up to dose. So if you're looking at semi-glutide, the dose that was studied, so did a one-year trial, or maybe it was a little over that, maybe 60 weeks.

Starting point is 02:40:03 But it took about 16 weeks to get the patients comfortably up to 2.4 milligrams weekly, which was the dose that they ultimately stayed on. In our experience, when we use it, we don't even usually go up to 2.4 milligrams. We can usually get enough benefit between one and two milligrams, and we usually move people along a little bit quicker,

Starting point is 02:40:20 but we've definitely had our share of patients who can't tolerate it due to the nausea. Interesting. Which might be part of how it's working, right, is definitely had our share of patients who can't tolerate it due to the nausea. Interesting. Which might be part of how it's working, right, is the sort of suppression of appetite, which if taken to an extreme can produce nausea. Interesting. Yeah, I think most of the effective of somnaglutide is central, not peripheral. Huh.

Starting point is 02:40:38 So, I don't know. I saw one paper that GLP1 is acting both on cells in the periphery to cause gut distension in some ways or sort of make people feel full through promotion of of literally mechanoreceptors that make people feel as if their stomach is distended even though their stomach is empty and then perhaps some central hypothelamic effects. Yeah, I think it's doing I would bet 80% of it's in the hypothalamus. It is also improving insulin sensitivity

Starting point is 02:41:08 and the periphery, but I don't think that that's accounting for much of its benefit. Super interesting. And there's next gen versions of these that seem to be more long lasting. So right now, if you look at coming off some agglutide, you're gonna see a weight regain. So there's newer versions that seem to preserve the weight loss, even off the drug.

Starting point is 02:41:29 So it begs the ultimate question, which is like, what's the total use case for this going to be? Is this going to be a drug you cycle on and off? Or is it going to be a drug that a person has to stay on indefinitely? And if so, will they become tacky-flactic? Will they gain a resistance to it? So it's still super early days on these things. My hope is that it would be a little bit like

Starting point is 02:41:47 the way that you described testosterone and estrogen therapies that it would allow people to do more of the behavioral work that's absolutely required for health spend and lifespan. Yeah, and we've also seen on the flip side of that you can cheat through semiglutide, right? People who, you know, you can drink a lot of calories and sort of get around the drug. So, you know, for example, like, you know,

Starting point is 02:42:11 we always encourage patients who want to lose weight to really just eliminate alcohol. Like that's like, that's the cheapest, easiest trick to lose weight. And so if you're still drinking a lot of alcohol, which is incredibly caloric, and just drinking a lot of caloric stuff. We've seen that that's less, this is just anecdotal in our, with our patients, but we've seen that

Starting point is 02:42:31 that's, it's easier to get around the benefits of the drug that way. I so appreciate your answers today. First of all, they were incredibly thorough and pointed towards real world application. I also just want to thank you more broadly for the work that you do, because obviously you have this incredible clinical experience and patient population that you work very closely with. But I see you really as one of the few, both clinicians and I realize you're an MD. did you do a PhD as well? No, but I consider you a scientist clinician, clinician scientist is the appropriate wording of that, of course, in the way that you really still drill

Starting point is 02:43:14 into studies in detail. I know a lot of clinicians, not all of them do that, for sure, and the fact that you're so hungry for the new incoming knowledge, as well as the old literature. So it's an incredibly rich data set in that brain of yours and I really appreciate you sharing it with us both in your podcast, in the upcoming book, which I think will certainly have you on here again in anticipation of that.

Starting point is 02:43:38 But I know I and a ton of other people are really excited for the book and in the way that you approach social media and your podcasts and going on podcasts. It, thank you so much. I learned a ton. I know everyone learned a ton. Thanks, Andrew. Great to be here, Matt. Thank you.

Starting point is 02:43:52 Thank you for joining me today for my discussion with Dr. Peter Atia, all about the things that we can do in order to maximize our lifespan and health span. I highly recommend people check out Dr. ITS podcast. The drive is excellent. As you can imagine, based on today's conversation, and it's easily available on Apple Podcasts, Spotify, Overcast, and Google. Please also check out Dr. ITS website. It's peteratiamd.com. There you can find links to his podcast episodes, as well as a sign up for his excellent weekly

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Huberman Lab - Dr. Peter Attia: Exercise, Nutrition, Hormones for Vitality & Longevity

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