Huberman Lab - GUEST SERIES | Dr. Matt Walker: The Science of Dreams, Nightmares & Lucid Dreaming
Episode Date: May 8, 2024This is episode 6 of a 6-part special series on sleep with Dr. Matthew Walker, Ph.D., a professor of neuroscience and psychology at the University of California, Berkeley and a leading public educator... on sleep for mental and physical health, learning and human performance. In this episode, we discuss dreaming, including the biological mechanism of dreams, what dreams mean and their role in daytime life. We explore how dreams can enhance our creativity and emotional well-being and help us resolve various challenges and dilemmas. We discuss how to remember and interpret your dreams and the abstractions/symbols frequently present in dreams. We also discuss nightmares and therapies to treat reoccurring nightmares. We explain what lucid dreaming is and if there are benefits or drawbacks to this type of dreaming. Dr. Walker also answers frequently asked audience questions and discusses snoring, body position, sleep supplements, sleep challenges due to aging, menopause, stopping racing thoughts, and how to fall back asleep if you wake in the middle of the night. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman LMNT: https://drinklmnt.com/huberman Helix Sleep: https://helixsleep.com/huberman WHOOP: https://www.join.whoop.com/huberman Momentous: https://livemomentous.com/huberman Timestamps 00:00:00 Dreaming 00:01:13 Sponsors: BetterHelp, LMNT & Helix Sleep 00:05:06 Dreams & REM Sleep 00:12:20 Evolution of REM Sleep, Humans 00:17:13 REM Sleep & PGO Waves; Dreams & Brain Activity 00:24:26 Dreams, Images & Brain Activity; Sleepwalking & Sleep Talking 00:30:51 Sponsor: AG1 00:32:04 Dream Benefits, Creativity & Emotional Regulation; Challenge Resolution 00:41:27 Daily Experience vs. Dreaming, Emotions 00:45:08 Dream Interpretation & Freud, Dream Relevance 00:52:59 Abstractions, Symbols, Experience & Dreams; “Fuzzy Logic” 01:00:28 Sponsor: Whoop 01:01:36 Nightmares; Recurring Nightmares & Therapy 01:11:08 Targeted Memory Reactivation, Sounds & Nightmares 01:15:38 Odor, Paired Associations, Learning & Sleep 01:18:53 Fear Extinction, Memory & Sleep; Tool: Remembering Dreams 01:25:38 Lucid Dreaming, REM Sleep, Paralysis 01:32:33 Lucid Dreaming: Benefits? Unrestorative Sleep? 01:44:07 Improve Lucid Dreaming 01:49:30 Tool: Negative Rumination & Falling Asleep 01:53:41 Tools: Body Position, Snoring & Sleep Apnea; Mid-Night Waking & Alarm Clock 01:58:43 Sleep Banking?; Tool: Falling Back Asleep, Rest 02:05:53 Tool: Older Adults & Early Waking; Sleep Medications 02:11:25 Tool: Menopause & Sleep Disruption, Hot Flashes 02:15:06 Remembering Dreams & Impacts Sleep Quality? 02:18:32 Tool: Sleep Supplements 02:26:48 Tool: Most Important Tip for Sleep 02:30:56 Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer
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Welcome to the Huberman Lab guest series,
where I and an expert guest discuss science
and science-based tools for everyday life.
I'm Andrew Huberman, and I'm a professor of neurobiology
and ophthalmology at Stanford School of Medicine.
Today marks the sixth episode
in our six episode series, All About Sleep,
with expert guest, Dr. Matthew Walker.
Today's episode focuses on sleep and dreaming,
as well as lucid dreaming.
We talk about what's happening in your brain when you dream, both mundane dreams as well as
heavily emotionally laden dreams. And we discuss how to think about and perhaps even
interpret the content of your dreams. And we talk about lucid dreaming, which are dreams that occur
while in sleep, of course, in which you are aware that you are dreaming. And because unfortunately they are relatively common, we also talk about nightmares and
both what to do about nightmares as well as how to think about nightmares.
This being the final episode in the six episode series, All About Sleep, I put the call out
on my social media handles for any and all questions about sleep that I could direct
to Dr. Matthew Walker.
So as today's episode closes, I ask him those questions, focusing specifically on the questions
that were most frequently asked by you, the audience, and he answers them in rapid succession.
Before we begin, I'd like to emphasize that this podcast is separate from my teaching
and research roles at Stanford.
It is, however, part of my desire and effort to bring zero cost to consumer information
about science and science related tools
to the general public.
In keeping with that theme,
I'd like to thank the sponsors of today's podcast.
Our first sponsor is BetterHelp.
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And now for my conversation with Dr. Matthew Walker.
Dr. Walker.
My dear good fellow, Dr. Huberman.
Today is the sixth and final episode
in the six episode series
that we've been recording on sleep.
During episode one, you told us about the biology of sleep
and some actionable items to get the basics of sleep
well worked out for each of us.
And it's highly particular to our individual needs.
And you explained how to define those needs.
And you beautifully described in-depth protocols
for let's call it optimizing one's sleep.
And then a third episode focused on caffeine, napping,
and also food intake and its impact on sleep.
We talked about the relationship between sleep and learning and memory and creativity.
And then of course in the fifth episode, just prior to this one, you beautifully described
the literature and actionable tools for connecting sleep to emotional health and mental health,
as well as the relationship between lack of sleep and certain mental health challenges or conditions.
Today, we are going to dive into a truly exciting
and fascinating topic, which is dreaming.
I can think of fewer topics, more intriguing than dreams.
I know there's a lot of interest in lucid dreaming.
That is one dreaming while being
aware that one is dreaming.
You can tell us more about that.
But I think dreams just intrigue and fascinate us for so many reasons, but not the least
of which is that at some point we all seem to have them and they seem to have a relevance
for our lives.
They're not just epiphenomena as we say.
So today I know you're going to explain
what they do and do not provide for us.
And I'm really excited to dive into this topic.
It's something that I've been fascinated by.
And I know many people are fascinated by.
So just to kick things off, how do we define dreaming?
What is a dream?
What is a dream state?
You would think it's fairly simple
because when people say, oh, I had the strangest dream last night,
everyone seems to know what a dream.
And by the way, dreaming is, we take it for granted.
We say, I had a strange dream last night.
Just think about it though.
Last night, both you and I and everyone listening,
as long as they slept, we all became flagrantly psychotic.
Now, before you reject my diagnosis of your nightly psychosis,
I'll give you five good reasons.
First, when we start to dream,
we see things which are not there, so we hallucinate.
Second, we believe things that could not possibly be true. So we're delusional
Third we get confused about time place and person so a suffering from disorientation
Fourth we have these wildly fluctuating emotions something that psychiatrists call being
affectively labile and
Then how wonderful, you woke up this morning
and you forgot most, if not all of that dream experience.
So you are suffering from amnesia.
If you were to experience any one of those five symptoms
while you're awake, we'd probably be seeking
psychological or psychiatric treatment.
But for reasons that we still don't fully understand, that seems to be a normal biological
and psychological, and in fact, and I'll describe the data, absolutely necessary life support,
perhaps necessary set of experiences to go through.
So that's the peculiarity of dreaming, but how do we define it?
One of the loose definitions that we often use in sleep science is that a dream is any
report of mental activity upon awakening.
So I'll come into the laboratory and I'll wake you up and I'll say, what was going through
your mind?
And if you just say, nothing really, then we note that down as no dream report.
But if you were to say, well, do you know what?
I was actually just thinking about the next time
you're going to come in and wake me up.
Then we would report that as a dream.
But that's not really what most people
mean when they say, I had this strange dream. What they're referring
to is dreaming that takes place during the stage of sleep called rapid eye movement sleep
or REM sleep. And during REM sleep, there we have these bizarre hallucinogenic, these
vivid, these narrative, these emotion-filled story experiences,
those are the types of reports that we get principally from REM sleep.
So if I were to go back to episode one and say,
think about those different stages of sleep,
light non-REM sleep, deep non-REM sleep, and REM sleep.
When does dreaming occur?
Well, if I wake you up during stage two non-REM sleep,
that's one of the lighter forms of non-REM,
early in the night, but especially later in the night,
you typically will report a dream,
maybe about 50% probability.
50% of the time I wake you up out of that stage,
no report, the other half, yes. If I wake you up out of deep non-REM sleep,
stages three and four,
we're down to a zero to 20% chance
that you'll report a dream, so very, very unlikely.
If I wake you up out of REM sleep,
somewhere between 80 to 90% probability
that you were going to report a dream.
There's nuance in that REM sleep story, by the way.
Rapid eye movement sleep is defined by those rapid eye movements.
But when you're in that stage of sleep, you're not always having the eye movements.
They come in these strange phases.
So you will be in REM sleep, and we can define that with lots of different sensors on your brain and your body.
But then there will be times when your eyes are darting back
and forth and times when your eyes are not.
And when those eyes are moving during REM sleep,
we call that phasic REM sleep.
And when they're not, we call it tonic REM sleep.
Don't worry about the terminology.
When I wake you up out of tonic REM sleep. Don't worry about the terminology. When I wake you up out of tonic REM sleep
when the eyes aren't moving,
I'm around that 80% probability.
If I wake you up out of REM sleep
when your eyes are darting back and forth,
there is 95 to 100% probability
that you're going to record a dream.
Some people theories in the past have said,
well, if that's the case,
then presumably those eye movements
are tracking something in the dream.
If you do careful analysis,
that just does not seem to hold up.
There is some evidence that that may be the case,
but your eyes are moving back and forth.
It seems that these are impulses that are going to your eyes
that don't have a strong correlation with what it is
that you're dreaming visually in the scene.
That's not the case.
But that's a little bit of a definition
of what dreaming is and also when dreaming occurs.
I should probably note by the, that we human beings, we seem to be special in our
REM sleep dreaming amounts.
Now I've just done a little bit of a sleight of hand.
When I say REM sleep, I'm going to infer that it's dreaming.
But Charles Nunn, wonderful scientist, has looked at the proportion of REM sleep across different mammals.
And what he found was that we human beings are a complete anomaly when it comes to our
relative amounts of REM sleep.
In other words, our dream sleep.
He found that across most other primates, REM sleep was usually averaging about 9% of
the sleep period. However, we human beings on average, including when we're young, will
have a REM sleep proportion of about 20%. So if you plot the amount of REM sleep of
primates in a graph, they're all sort of clustered
around this mean.
And then all of a sudden on the far right-hand side, you've got this one single data point
that sticks out.
That's us, human beings.
And we don't fully understand why it is that we have such exceptional amounts of REM sleep.
Now I've done a lot of hand waving and written some theories about why that is,
but it's still very unclear.
The other thing, and that's a very,
I can go very philosophical about the functions
of REM sleep and how it changed as we made the transition
as a species from tree to ground.
Because don't forget, as we mentioned in one of our episodes,
when you're hanging like a bird on a tree
or you're resting on a branch as a primate up in the trees,
and you go into REM sleep, you lose muscle tone.
So it's quite a fragile state when you're 30 foot up in the air
and you've got gravity desperately wanting to bring you and your limbs down to the ground.
But when we made the transition down from tree to ground, we no longer had to worry
about that.
Did that open up the opportunity for more REM sleep to occur?
And that explains why we human beings have that.
We don't know.
REM sleep, however, does seem to be quite fundamental,
and fundamental from a life-necessary perspective.
There were some studies done back in the 1980s,
and there are studies that have not really been replicated,
and I think I agree as to why, because ethically,
you know, they're right in that gray zone.
In fact, for me, I find them quite uncomfortable
when I speak about them or even teach them in class.
They took rats and they deprived them of sleep totally.
And what they found was that rats on average
will die somewhere between about 13 to 17 days
after total sleep deprivation.
In other words, rats will die almost as quickly from sleep deprivation as they will from food deprivation. In other words, rats will die almost as quickly
from sleep deprivation as they will from food deprivation.
It's that essential.
Brutal.
But then they did something different.
They said, well, what about the different stages of sleep?
So they selectively deprived them
of either non-REM sleep and REM sleep.
The hypothesis was perhaps that non-REM sleep is, from an evolutionary perspective, a much
older form of sleep.
The first stage of sleep that came into being was non-REM sleep.
And the way we answer that is we look across phylogeny and these sort of different branches.
And what we find is that in insects and in reptiles, amphibians, and fish, they all seem to have non-REM sleep.
But for the most part, with a few exceptions, they don't seem to have REM sleep.
But if you look at birds and mammals, they do have REM sleep.
And in fact, it seems as though REM sleep evolved twice independently, once in birds,
once in mammals, which tells us probably that it's essential
if it's being forced through the evolutionary pipe
twice independently.
So you would argue, well,
if I selectively deprived you of non-REM,
the older stage of sleep,
presumably that's more life support necessary,
and REM sleep,
REM sleep is the new kid on the block, evolutionarily.
They found the opposite.
They found that if they selectively deprive rats just of non-REM sleep, they did die,
but it took them longer.
They died after about 60 days.
If you deprive them of REM sleep, dream sleep, they died after 40 days versus 60 days.
The words, this new type of sleep, REM sleep,
seems to be on that basis,
maybe even more important to supporting life
than non-REM sleep.
It's super interesting.
And as I recall from graduate school,
there are certain patterns of brain activity
that occur during a rapid eye movement sleep.
Maybe we could go a little bit deeper
into those patterns of activity.
I know you touched on some of these patterns
in the first episode.
The thing that comes to mind here is PGO waves,
Pond's geniculate occipital, Pond's being an area
of the brain stem that is chock-a-block full
of different neurons involved in basic functions,
rhythmic breathing, eye movements,
and basic reflexive functions that preserve the well-being and life of the animal.
And that the neurons there then do indeed connect to the thalamus.
This is like a shape structure in the middle of the brain where you have something called
the geniculate, which is a, there's an auditory geniculate and a visual geniculate, but that projects to this relay station for vision
mainly and hearing.
And then it goes up to the occipital lobe, the area in the back of our brain that incited
people is responsible for conscious perception of images.
And I was taught, and I don't know if this is still true, that based on the work of people like Mersey Steriad
and folks like that, that these pons, geniculate,
occipital waves of activity that were ongoing during sleep,
I think during REM sleep, were essential for resetting
something essential about brain function and wakefulness,
so that you needed these PGO waves,
and that maybe even the activation of the visual pathway
was part of the reasons why we often experience
such robust visual hallucinations during dreams.
What is thought about PGO waves?
Are they related to rapid eye movement, sleep,
and are they somehow the reset
that we need and indeed is essential for life?
Because as you pointed out,
in the absence of rapid eye movement sleep, we die.
It's a great demonstration of the uniqueness of your brain.
Essentially what we're asking is,
this is your brain on dreams. Explain.
And REM sleep has many different brain features to it.
The first of which is, as we spoke in the first episode,
your electrical brainwave activity at the top of the brain,
the cortex, looks almost identical to that
which you have when you're awake, which is stunning,
because you're not conscious.
You're lying completely still, no presence of muscle tone whatsoever, yet your brain
seems to be just as on fire with electrical activity as it is when you're awake.
Coming down a step though, there are these unique pulses of electrical, almost like lightning bursts that come up from the brainstem up
to this sensory relay center in your brain called the thalamus.
And then they were initially recorded out in the back of the brain in the visual cortex.
Hence this PGO waves describes the three sites that I've just mentioned.
It goes from the brainstem, the pons, up to the thalamus, a part of it called
the geniculate, and then out to the back of the brain called the occipital cortex, PGO.
What they found was that those bursts of PGO wave activity were very much linked to these
rapid eye movements.
So once you got this burst of a PGO wave, this sort of brain stem up into the brain burst,
then you got one of these rapid eye movements.
So it was linking something there with the eye movements.
And I told you that when you're having these eye movements, that's a state where there's
a high probability of dreaming.
And is it a surprise then that the final destination of that lightning bolt where it sort of strikes
is at the back of the brain in the visual cortex? Probably not. There's also
been some links with those PGA waves and learning. Not so much that those PGA
waves seem to consolidate memories. In other words, they may not be critical for
sleep after learning, but they seem to be related almost to sleep and
initial learning and the more that animals learn the greater the amount of
PGA wave activity they have when they go to sleep. So PGA waves are unique. PGA
waves don't simply just hit the back of your brain that we've now measured them
in all sorts
of different cortical areas,
and they seem to light up the lightning splits, as it were,
and it strikes all sorts of cortical areas.
So then the question was, well, let's take humans
and let's put them inside of brain scanners.
Let's allow them to fall into REM sleep,
and then we'll start scanning the brain.
What did we find?
It was very interesting.
When you look at the brain during REM sleep compared to let's say non-REM sleep, you see
motor regions of the brain lighting up.
You see visual regions of the brain lighting up, just as we described.
You see memory related structures lighting up like the hipp as we described, you see memory-related structures lighting
up like the hippocampus, and you see emotional-related structures like the amygdala and something
called the anterior cortex, the anterior cingulate cortex, I should say.
So if I were to just show you an expert, a brain imaging map with memory centers related
in terms of their activity, emotion centers,
visual centers, motoric centers.
And I was to say to you, Andrew,
this is a scan that we got from an individual.
Just describe the type of experience
that you think this person was having in the scanner.
You would probably look at it and say,
well, they were probably recollecting things
from their past memory structures.
They seemed to be having a visual experience,
but there was also probably movement involved
in that brain scanning experiment.
And also there seems to be some degree
of emotionality to it.
That sounds strikingly similar
to what we know dreams are like.
With one exception though, another part of the brain bucked the trend of increased activation
during REM sleep.
That part of the brain with the far left and right sides of your frontal lobe, something
that we call the dorsolateral prefrontal cortex, terrible mouthful word salad, essentially
just means the far left and right sides of your prefrontal cortex, terrible mouthful word salad, essentially just means the far left and right sides
of your prefrontal cortex.
Those are very important for logical,
rational thinking and decision making.
Those parts of the brain went down in their activity,
almost as though they were suppressed
during REM sleep dreaming.
So now let's go back to our map.
You're having a visual experience,
it's filled with movement and memories and emotions,
but it's utterly bizarre, completely illogical
and totally irrational.
If that's not a perfect neural definition
of this thing called dreaming, I don't know what is.
It's so interesting.
We think of dreams, or at least I think of dreams
as a fragmented representation of real world experiences
from our recent past, maybe even the previous day,
you know, sort of meshed with our distant past experience.
And then of course, our brain is also a very good anticipatory machine.
And somehow, you know, puts that into a movie that, for all purposes, when we're in it,
we feel as if it's happening in real time.
And then, of course, we try and untangle what the meaning of all that is.
I think people are really intrigued by dreams because they just feel so real to us
and yet we know they're not of the same real
that is our waking experience.
And throughout history, people have alluded to the idea
or have been convinced of the idea
that dreams are meaningful
and something we're going to get into.
And I should mention, by the way, that your dreams based on those brain scans
still remained your own.
You were the only person privy to the experience of the dream itself.
I could stick you in a scanner and I could say, you know,
were you having a visual dream and was it, you know,
filled with motor activity and emotions and memories?
That tells me how you're dreaming.
It doesn't tell me what you're dreaming.
So at that point, you still had this degree
of security and privacy.
No longer, it seems.
There was a great study done by a Japanese group
using very advanced brain
imaging technology and techniques such as multi voxel pattern analysis, again word salad,
but it's a very clever technique and they were able to start to understand exactly what
you Andrew Huberman were dreaming and they would know what you were dreaming, even before
you woke up and told us what you were dreaming.
And they did a two-part experiment.
First, they showed you lots of very specific images, images of cars, of women, of houses,
of men, of dogs, of cats, of just a whole category of different visual elements.
And your brain was being scanned as you were awake watching each of these.
And then using this clever analysis, they were able to build up this very specific pattern,
this very specific template of activity that for you, Andrew Huberman, said he is now looking specifically at a set of keys,
or he was looking at a car, or he was looking at a woman, or a man, or a house.
And we knew ground truth in terms of what your brain looks like when it is seeing these different categories.
And then they did something clever.
Then they let those individuals sleep and go into REM sleep. is seeing these different categories. And then they did something clever.
Then they let those individuals sleep and go into REM sleep.
And then they started waking them up and getting dream reports.
But once they got the dream reports, the analysis sort of team remained blind to those reports.
What they did was almost like a forensic team that goes hunting for DNA at a crime scene.
They had the DNA and they started going around and searching to see if they could find a
DNA match.
But here they weren't using the DNA.
They were using these templates of a woman's face or a car or a house.
And they would search through this electrical, this brain activity, sort of static of your dreams at night
and find these matches.
And then we could wake you up, get the dream report
and see how well did our brain performing
a sort of algorithm match with your actual subjective report
when you came out.
And it was stunning how close.
So I could tell you were dreaming, but you were also dreaming about a house and a car.
You're dreaming about a woman, turns out.
And we started to want your dreams, as I said, were your own, but now no longer because science
can start to reveal those.
What we can't yet do is understand which specific woman in which specific house.
So what you would probably see my brain based on my own proclivities lighting up is it would
just be full of cars probably, sports cars, and then maybe another special individual woman.
Those two things would be dominant,
but you wouldn't know that I'm dreaming
about the new Porsche 911 GT2 RS.
You can't tell it.
You can just simply tell me he was dreaming about a car.
So there is still some distance to go.
I can't help but ask based on what you just described,
when people say things in their dreams,
when they sleep talk,
how faithfully does that report what's in the dream?
It doesn't at all.
And the reason is because when you're sleep talking
or sleep walking or even sleep eating,
you're not dreaming because you're not in dream sleep.
This is one of the fallacies that sleepwalking
or sleep talking, you know, stop dreaming,
wake up, you're dreaming.
You're waking someone out of the very depths
of deep non-REM sleep.
And these different things, sleepwalking, sleep talking,
sleep eating, sleep, there's sleep associated sex behavior,
all of these things are what we call parasomnias, sleep, there's sleep associated sex behavior.
All of these things are what we call parasomnias. Para meaning sort of around somnia, obviously sleep.
So these are things that happen around sleep,
but they're not quite in sleep.
Because when you have those, you are launched
from deep non-rem sleep up to wakefulness, but you don't make
it all the way to wakefulness.
And so you act out these very rote, routine, reflexive behaviors.
You just repeat certain words.
You lift a cup to your mouth, go over to the refrigerator.
So they are not faithful to the dream because if I were to gently wake you as you're sleep talking and say what was going
through your head, you'll say nothing at all
and you don't report a dream.
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Earlier in this series, you described beautiful experiments Again, that's drinkag1.com slash Huberman.
Earlier in this series, you described beautiful experiments by Matt Wilson and others at MIT
who explored neural activity within the brain, within the hippocampus in particular, an area
associated with memory formation in which the neurons in the hippocampus fire in the
same sequence as they did during a
particular daytime activity that preceded that night's sleep, but they do so at a much
more rapid rate.
Sometimes they play in reverse, et cetera.
This raises the question of, first of all, is that sort of neural replay of events from
the prior day, is that also associated with dreaming? Or more specifically, is that dreaming?
Or is dreaming that?
And that's really to raise the larger question,
which is what is dreaming for?
What is the function of dreaming?
So what we know is that Matt Wilson's data
during non-rapid eye movement sleep,
the brain was replaying those memories
10 to 20 times faster.
But when you go into REM sleep, it's down to 0.5 times.
So listening to this podcast now and you hit that speed button and you drop it down to
0.5, that seems to be the replay speed during REM sleep.
We've not yet been able to confirm that in human beings, but if we did, does
that mean we can explain the time differences that seem to happen in the dream state, that
time is longer in the dream world than it is in the waking world? I think that's fascinating.
But you're right, it does point us more towards the question, though, of what are the functions of this state called dreaming.
And we can get onto whether or not dreaming is a very
faithful recapitulation of our waking experiences.
And I'll give you a spoiler now, no.
But I'll give you the data in a second.
But the functions of dreaming come back to some of the functions of REM sleep that we
described in an earlier episode.
Those two related functions in the episode on learning and memory was that one function
of REM sleep seems to be creativity, associating memories together so that you can come up
with these wonderfully divine
solutions to problems you couldn't answer when you were awake.
The second came in our last episode about emotional and mental wellness, and we spoke
about this theory that we put forward that REM sleep is a form of overnight therapy,
and we described the evidence supporting that therapy. So I would say that those are the two leading theories
of REM sleep and associated dreaming.
But I perhaps didn't give you the full story there.
There is a twist in both of those stories.
I told you that when you are in REM sleep
and you're dreaming, the next day you are better able
to assimilate
and associate memories and come up
with these creative insight solutions.
It turns out that sleep is necessary for that
and not just sleep, but dream-related sleep,
REM sleep is necessary for that, but it's not sufficient.
You not only have to be asleep
and dreaming to get those benefits,
you also have to be asleep and dreaming to get those benefits, you also have to be
dreaming of the very things that you are trying to solve the next day.
There's a great study by a scientist called Robert Stickgold at Harvard, and he had a
whole group of individuals learn a virtual maze, and they were dropped down in different
locations of the maze, and they had to try to get out of the maze. And gradually, when you're dropped down in different locations of the maze and they had to try to get out of the maze.
And gradually, when you're dropped down in different locations,
you do that enough times, you start to build up this mental map of the maze.
And then he let one half of those participants take a 90-minute nap
and the other half remained awake.
And then some hours later, they tested them on the maze
and they measured how quickly were you able to navigate
and get out of the maze.
That was the outcome measure.
And sure enough, just as we described,
those people who slept versus those who didn't,
they were better able to navigate the maze
after they had slept versus those who remained awake.
But then they went back and they separated those individuals who were napping into two
classes, because as they were napping, they were waking them up intermittently and getting
dream reports from them.
And what they found was that those people who slept and still had dream reports, but
those dreams were not related to the maze,
they didn't show an improvement.
But those individuals who slept and who dreamt,
but also dreamt of the specific maze elements themselves,
they were the only subset of people, of participants,
who showed the benefit.
And that's a beautiful demonstration that, yes, you need to sleep to get creative benefits
and in fact seemingly have dream sleep, but you also need to be dreaming about specific
things.
Is that rule true for the second function of REM sleep dreaming, this overnight therapy
benefit?
Yes, it does seem to be true.
There were some great studies by a scientist who has sadly passed away now, Rosalind Cartwright, I'm sleep dreaming, this overnight therapy benefit. Yes, it does seem to be true.
There were some great studies by a scientist
who has sadly passed away now, Rosalind Cartwright.
And she was looking at different patient populations
who had undergone really painful,
difficult emotional experiences.
For example, a very bitter, painful divorce.
And she would, at the time that those individuals
were going through this difficult challenge,
she would be recording their sleep,
looking at their different stages of sleep,
and she was collecting dream reports from them.
And then she would track them
and their progression clinically over the next year.
And what she found was that some of those participants, about 50% of them, ended up
getting clinical remission from their depression that was instigated by the painful experience
they'd gone through.
The other half did not get clinical remission from their depression.
They remained depressed.
And then she used those two classes to go back
and have a look at the sleep and the dream reports.
And what she found was some differences in REM sleep,
but more interestingly,
were the differences in their dreams.
Both of those sets of individuals were dreaming
at the time of going through
those difficult emotional experiences.
Some of them, however, were dreaming
of that challenging however, were dreaming
of that challenging experience, others were not.
Those who dreamt, but also dreamt of the problematic
experience were the ones who went on to get
clinical resolution from their depression.
Those who dreamt, but did not dream of those events
seem to be the ones who did not get clinical remission
from their depression.
In other words, here, once again, is this new rule
that when it comes to dreaming, it's not just about sleep,
and it's not just about dreaming,
it's about dreaming of the specific things
that you're trying to get the functional benefit from,
whether that's creativity and insight,
or whether it's emotional resolution
and overnight therapy, both of them seem to depend very much on the expression of dreaming
of specific things itself.
And we'll come on to why that's maybe relevant when we speak about lucidity too.
What you just said is very reassuring, at least to me, because when I'm going through a challenging phase,
which somehow seems to happen periodically in my life
at a frequency that, let's just say,
keeps me dreaming about things.
You're not alone, by the way.
No, I'm sure I'm not, which is why.
No, no, I didn't mean that.
I just mean that there are lots of people
who can resonate with that.
So thank you for being vulnerable and sharing.
Yeah, yeah, it's one of these things where I put my head down on the pillow, I mean, that there are lots of people who can resonate with that. So thank you for being vulnerable and sharing. Yeah.
Yeah.
It's one of these things where I put my head down on the pillow, fall asleep, and assuming
I can get good sleep amidst those real-life events, which is something that sometimes
is the case, sometimes it's not.
I always dream about things related to those events or those events in particular.
I'm a long-time practitioner of writing down my dreams when I wake up from them or as we
discussed in an earlier episode, my phone is on airplane mode at night.
Typically I'll grab my phone and I'll hit the voice memo button or function rather and
I'll just in my groggy state with my eyes
closed so I'm not getting any light in my eyes, I'll say, you know, I'll describe what
I can recall of the dream.
Then I'll sometimes go back and listen to those recordings.
And they've provided me insight and in some cases a path to solutions.
So I'm 100% on board the fact that our dreams can help us resolve challenges in our waking day.
What's always fascinating to me though is how the dreams are not a one-for-one representation of what happened during the day.
I think symbolism is a hallmark feature of dreams, and that's something I know we're going to talk about in terms of dream interpretation,
and much has been made of this throughout history.
So it seems that when we're asking
what are the functions of dreaming,
one of them is to resolve challenges
from our daytime experience.
Yeah, it's emotional first aid.
Yeah, that's beautifully put.
And in an earlier episode on learning memory and creativity,
you described how specific sleep stages
and perhaps dreams themselves are involved
in the consolidation of memories from daytime experiences
or things that we're trying to learn
from daytime experiences.
And then in the episode on sleep and emotions,
it was made very clear that rapid eye movement sleep
is a time
in which we get a sort of therapy
that is a disentangling of the emotional load
of a given experience from the experience.
So to me, it just seems so clear,
like dreams are critical, sleep is critical.
But I think one question that still remains unresolved,
at least for me, is are dreams really there
to just be a replay of our waking lives
with some distortion because when the conscious mind
is asleep, the unconscious mind can kind of throw things
up to the surface in ways that don't seem so obvious.
Symbolism, analogy, some of us are more visual than others.
Are there any rules about the way that dreams
convert our waking experiences into dream content?
There are, and the short answer to your question,
do we simply go into sleep, start dreaming,
and then rewind the videotape and replay in a faithful recapitulation
the waking day in our dreaming night?
And the answer is no.
And here again, the scientist I mentioned before,
Robert Stickgold with Raw Fosse,
they looked at this question
and it was a very difficult study to do.
They did what we call experience sampling during the day and they would give you sort
of like a little beeper and they would set it to go off multiple times throughout the
day and then you would write down what it is that you were experiencing right in that
moment.
And again, they were trying to build up this sort of time lapse photography, as it were,
of your waking day experience.
And then they would bring people in
and they would start to record their dreams at night.
And then they would match those two
and ask what is the degree of overlap?
What is the Venn diagram proportional percentage
of those two things aligning?
And what they found was that there was really only about 2% of your dreaming life that was
a very faithful replay and reiteration of your waking life.
However, what they did find was something even more interesting to me, which comes back
to this idea of overnight therapy.
They found that there is something that runs through
like a red thread narrative from your waking life
into your dreaming life.
That is emotional concerns and people of significance.
If there is anything in terms of an algorithm
that seems to overlap and predict
where those two Venn diagrams sort of collide.
It really is in the emotional, personal significance space,
once again pointing us to perhaps a reaffirmation
that a key function of dreaming is about dealing
with our waking experiences and particularly the things that are salient to us.
Okay, so clearly there's a functionality to dreaming,
but what should we make of the specific content
of our dreams, really?
Meaning, should we interpret our dreams
or should we allow anyone else to interpret our dreams?
There are scores of books out there, websites, programs.
There's a long history of this in classic psychoanalysis.
What about this dream interpretation business?
I mean, it really started, you have to give credit in some ways to Freud.
Although if you look back at very ancient cultures, so much of their artwork, so much of their sort of left
imprint on the world suggests that they were fascinated by dreams and used dreams and gods
of dreams.
So we've always been thinking about what are these things called dreams and can we interpret
them?
But it was really Freud who put his seminal works together in 1899 and then published
it in 1901 called The Interpretation of Dreams and it's probably one of his, if not his most famous
text. And you can unfairly sum it up as, you know, if it's not one thing, it's your mother, when it comes to Freud.
But in some ways, Freud, with his interpretation attempt,
in my mind was 50% right and 100% wrong.
Because until the moment that Freud came along,
we left the interpretation and the instigation of our dreams to things outside
of us.
Maybe it was there were comments that it was due to our soul or it was from the gods on
high that they would descend down these dream manifestos to us.
But Freud, full credit, was the first person to put dreams front and center into
this thing called the brain, the mind.
So in some ways, Freud shifted dream science from really more of a sort of spiritual philosophical
condition to very much a neuro science.
It was of the mind and therefore of the brain.
And earlier he had tried to describe the neural patterns and he had these beautiful drawings
of neuronal circuits that could try to explain what was going on.
But neuroscience was so anemic at the time in terms of its knowledge, he had no chance
to do what we can do now. So in some ways, it's very unfair of me to criticize him as his theory being non-scientific.
It is also non-scientific in the very strict sense of the word.
When we create a scientific theory, just as though he created his interpretation of dreams theory. We allow that theory to be testable,
which is to say that a scientific theory
is only a scientific theory
if it can be falsified or supported.
But Freud's theory was not a scientific theory.
It was not something that you could test
and therefore it was not able to be falsified
or affirmed.
And in some ways it was Freud's simultaneous downfall and his utter genius.
It's the reason that Freud remains to this day because we can't put him away in a box
and say,
we've disproven him,
but we equally will never be able to prove him.
And therefore he's been in some ways,
let go in hard science as being representative.
His theory, which we don't need to get into,
which was called disguised censorship,
was really a very interesting proposition, which was that
there was something about our dreams that was veiled and masked.
And Freud believed that he understood the decryption code to our dreams.
And if you tell him your dream, he has the special filter that he can pull that dream through the filter
and magically out on the other side
is the true meaning of that dream.
There are several problems with that theory,
not least of which I think, you know, at the time,
if you look at his writings,
it seemed that Freud was probably doing enough cocaine
to kill a small horse at the time,
but we'll put that aside for a second.
The issue there is that it's not very replicable as an analysis method.
And there's a fascinating study that was, I remember from a conference, I should check
to see if it's been fully published.
And they did something clever.
They took the Freudian method and they took a single dream from one individual
and they had three Freudian psychoanalysts analyze that dream.
So it was the same dream, but three different analysts.
Now in a scientific protocol, if it's a scientifically rigorous assessment tool, you would get back
the very same answer from that measurement
technique all three times, all very similar.
So for example, a carbon dating machine, if I were to take a fossil and put it in a carbon
dating machine, and then another one and another one, for the most part, they're probably going
to return something that's much more similar than different in terms of the carbon date of that fossil.
Why?
Because it's been very well validated and replicated.
That's what you want from a scientific method and tool.
But when they gave the single dream, the fossil as it were, to these three different interpreters,
the three different carbon dating machines, they all came up with completely different
interpretations.
And so that's not necessarily a reliable, valid method.
So in that sense, we've abandoned and let go of Freud
as being relevant or meaningful.
However, I personally, and I think if you look at the data,
I don't mean that to suggest that you should not try to
think about and quote unquote interpret your dreams.
And the term interpret when it comes to dreams is so loaded,
so I tend to, I would just simply say,
see if you can really deconstruct some of your dreams.
I think dreaming, just as we've spoken about,
is a very solid window into the things
that you should be concerned about from your waking life.
It's very obvious that whatever it is
that we typically dream are the things
that our brain is telling us, the human being,
this is the stuff that's essential.
This is the stuff you need to work through.
This is please pay attention to me.
And any amount of journaling or deliberation, digestion,
cogitation of that specific dream
is going to be beneficial to you.
Because in my mind, a life unexamined
is not a life well lived.
And that isn't just applicable to your waking life.
It's especially applicable to your dreaming life.
Now, does that mean I'm suggesting
that everyone should race out and start cataloging
and interpreting their dreams?
Not necessarily.
But I am saying that if you wish to do that,
I as a scientist based on the data,
I'm not telling you that that's who we and non-scientific.
I think it's very valid.
It's just that some of the Freudian principles,
I think we've been able to dislocate ourselves from.
I wholeheartedly agree with what you just said.
And I've spoken about dreams and their possible relevance
to clinicians, psychiatrists, such as Paul Conti and others,
some who have more of a psychoanalytic training than others.
But certainly folks like Paul know a ton of neuroscience.
They understand pharmacology.
They understand family systems models,
dialectical therapy and so many other.
That man is, he's extraordinary.. That man is, he's extraordinary.
He's not extraordinary, he's extraordinary.
He is extraordinary, and in part because he can synthesize
across all these different domains of psychiatry,
psychology, neuroscience, et cetera,
as opposed to just existing in one silo,
like psychoanalysis or psychopharmacology.
And there are others, although few as extraordinary
as Paul, which is why we hosted him on the series here.
And one of the things that has come up in the discussions
with Paul and others with similar training about dreams
is that dreams seem to present us with emotional states
and scenarios for which there's a lot of swapping in and out of identity.
So for instance, the notion of symbols within dreams is a longstanding conversation.
And I think one of the mistakes, as I understand it, is to assume that every time there's an
animal in your dream that it represents children or that every time it's a particular kind
of animal, it represents, you know, your boss or something.
Sometimes a cigar is just a cigar.
Right.
Right.
On the other hand, it's very clear that within our dreams, there's rarely a completely linear
one-for-one relationship with what happened in the daytime of real experience.
So there seems to be a swapping in and out.
And there I just sort of zoom out
and forgive me for going long here,
but I think this would be a good fodder
for exploring this a little bit more deeply.
You know, one of the best descriptions of brain function
that I've ever heard is from the Nobel Prize
winning neuroscientist, Richard Axel at Columbia,
who often talks about the brain creating abstractions of the outside world.
So if I were to take a photo of your face, for instance, and then show you that photograph,
you'd say, yeah, that's me.
But if I were a painter, I might swap some of the positions of components of your face
and show it to you.
And you might say, well, that doesn't look like me.
And I'd say, but that's my abstraction of your face.
So to me, it makes sense because I understand the rules by which I made those swaps and
moves.
There's some algorithms or rules that are known to me.
So there's a preservation of real world to the abstraction.
And that's really what our brain does all the time.
It attempts to faithfully represent the world around us, but it is indeed an abstraction.
And when it comes to the colors of things or the position of objects, it's as one for
one as our brain is capable of.
But when it comes to ideas, to feelings, to our relationships to other people, the brain
abstracts those in its own little neural symphony of this is the relationship to my dog, this
is the relationship to my friend and colleague, Matt Walker.
So it makes sense that in dreams, those algorithms could be different.
They could be faster or slower,
but they could also be entirely different.
And I don't think we yet know what the algorithms
of transformation of real world experience
to dream experience are.
And once we do, and I think someday we will understand
those through electrical recordings and MRI type experiments and some
of the experiments you talked about earlier point to this.
So I think it's entirely reasonable to assume that we each have our own unique abstraction
algorithms so that indeed we can have consistent representation of real world experiences and
symbols but that it's not going to be the same for everybody. Correct.
Right?
Your way of abstracting your real life to your dream life could be entirely unique to
you, and mine could be entirely unique to me, making it very difficult for a third party
to come in and say, okay, Matt, here's what your dream means.
But you can know what your dream means if you explore your dreams over time, not just
that one dream.
Does that make sense?
It makes total sense because in some ways,
there is no one who knows your own autobiography,
by definition, than you, than yourself.
Now, I'm not suggesting that having that interpretation
guided by someone who also understands
the emotional problems that you're having
and also sees your blind spots,
which is what a really good therapist can do,
can then help with that interpretation.
But you're right because my representation of information
in the brain is going to be very biased by also
what I've experienced in the past
and how that past experience augments and modulates
the current representation of that information and thus
the meaning of it for me, the unique individual.
And you're also right to say that it's somehow, you know, it's almost as though you're squinting
your eyes when you're in dream sleep in terms of the true vision of things.
Things get a little bit wacky and distorted, this bizarre nature.
There is some very interesting data, and it comes back to what we described earlier, the
neurochemistry of the REM sleep state.
I told you that during REM sleep, levels of noradrenaline are at floor levels.
Noradrenaline is shut off.
One of the things if you sort of drop noradrenaline onto neural circuits, it will very much increase what we call the signal to noise. And this
is why neuroadrenaline, when it's released or if you administer it to an animal, you
can become very, you can become almost more directed. You're much more divergent. You're focused in attending, and it's really there.
You're very blinkered.
You're very focused.
But when that goes away, the neural circuits become a little bit more loosey-goosey.
And I also told you that the other chemical, if there is a neurochemical that defines REM
sleep dreaming, it's this thing called acetylcholine.
And acetylcholine seems to do the opposite.
It seems to inject a little bit more noise relative to the signal.
So in other words, your brain circuits are neurochemically modulated when you dream to
inject almost what we would think of as fuzzy logic.
And this is why I think the analogy that we spoke about
in a previous episode holds that when you are awake
and you're given some information,
you produce the most obvious links and obvious associations
because you're very much blinkered
and you have noradrenaline on board.
But when you go into dream sleep,
it's almost like the Google search,
when you're awake, go straight to page one and it's almost like the Google search. When you're awake, go straight to page one
and it's very related.
But do that same search when you're in the dream state
and you go straight to page 35
and it's an utterly bizarre page.
And you think, hang on a second,
this has got nothing to do with the search term.
When you read it, you think, well, if I squint my eyes,
it kind of does.
It's very distant, very non-obvious,
but that's a very smart connection
that as a waking brain, I never would have put together.
So I think neurochemically, we can start to understand it,
but I think this is a very good important point
where you could almost say the very best person
to interpret your dreams is probably you.
I want to take a brief break and
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Some dreams we'd rather not have.
Here I'm specifically referring to nightmares.
I've had one nightmare countless times throughout my life.
I won't share what it is.
It's not a real world experience,
or at least it's not a one for one of real world experience,
but I've had this nightmare since I was a kid.
I have it seldom these days,
but every time it starts again, I'm like, oh no.
And that's just a bit of a lucidity to it.
Where I'm like, I hear him again.
Been working on this one a while, as you can imagine.
But given what we understand about the relationship
between real world experiences and dreams,
what should we make of the fact that we have nightmares?
So let's just start there.
The phenomenon of nightmares.
Does it represent something that troubled us in the daytime
and that we're trying to work out in our sleep?
And then maybe we can get into some of the specifics
around why, regardless of whether or not the answer
to that question is yes or no,
that we would have this thing called nightmares,
especially given that there's all this machinery
to make sure that we don't move
and the noradrenaline is low in the brain
while we're dreaming.
Seems like there's all sorts of mechanisms
to try and ensure that our dreams are very pleasant
or at least neutral.
But nightmares suck.
But so I'd love to know that.
Get me that T-shirt please.
So I'd love to know that they serve some utility.
So nightmares, how do we define a nightmare in science clinically?
It's a little bit tricky, but usually the way we define it is it's a strongly unpleasant
dream that causes some time of daytime displeasure.
So in other words, some type of daytime dysfunction or distress.
So everyone can have a bad dream, but when you go up into your waking life and about
your waking day, it doesn't seem to bother you too much.
And maybe we'll just say that's a bad dream.
When it really becomes a nightmare is when I almost think of it as though you wake up
and that blanket of strong nightmare emotion is still
wrapped around you and you can feel it.
You can just know that my emotional state is still heavy and I know exactly where it
came from.
And it was from that nightmare.
And throughout the day, you don't seem to be able to derobe yourself from that cloaked affect of the nightmare.
It drenches you almost.
That's where it really starts to become unpleasant.
And we actually do have a clinical category.
It's called nightmare disorder.
And the way we typically define that is the same thing, as I said, a very unpleasant
dream that causes some type of daytime distress,
and it's happening at least once a week.
At that point, we start to move it into this category
of nightmare disorder.
What are nightmares doing, if anything at all?
There are at least two theories.
One is that it's simply the system failing,
the system gone wrong, and we're not processing,
we're not moving through things,
and therefore nightmares are maladaptive.
They're not warranted, they're not normative.
The other is that no, they are adaptive,
and they are meaningful, and it's us really trying to go to a very
specific pain point and we continue to process it over and over, perhaps to the point where
we get resolution, but sometimes we just don't so it keeps cropping up.
We don't have good data to disambiguate those two right now. So I think it still remains open.
At least I don't know of any data that tells me,
are they functional or are they maladaptive?
Even when we get that answer, in some ways,
it doesn't change the fact that it still leaves a patient
with nightmares, with recurring nightmares.
So then what do you do about that?
How do we, is there any treatment for people out there if they're under this distress?
Is there hope?
And for a long time there really wasn't very much hope at all.
You just had to go through it.
But recently there was a method that was developed and it's very effective.
And it is called IRT, which stands for Image Rehearsal Therapy.
And its basis comes back to something that in fact we, I think, hopefully published the
first evidence in humans of some years ago now called memory reconsolidation.
So in our episode on learning and memory,
we said that there is at least sort of
two main steps of memory.
First, you have to imprint and learn the memory,
lay down that memory trace,
but then that memory is very fragile and vulnerable
to being overwritten by competing information
knocked out of place.
And for you to hold onto that memory,
you have to go through a second step
called memory consolidation, a very slow process.
It's like a very slow pressing of the save button
because it's biological,
it requires protein synthesis and all of that good stuff.
But that always struck me as a strange model
because it's the equivalent of opening up a Word document.
You type out all of the information into it, and then you hit the save button.
So I've encoded, imprinted the information, then I've hit save and saved it.
And then I close that file.
And then the next day I come back or some days later and I double click on that file
again because I want to edit it.
I either want to add to it or I want to revise it and change it.
But according to that model, it's been logged in place
and you could never edit that Word document.
That seems like a profoundly useless way
to store information.
And what we learned is that every time in subsequent days
when you reactivate, which is to say,
when you recollect the memory
that has been consolidated,
it opens that memory file back up
to once again being plastic and malleable.
So you can go in and update the information
in that memory store, and then the next night,
you consolidate it again.
In other words, you re-consolidate it.
So it's memory updating,
and there is a very clear mechanism in the human brain
that allows us to do this memory updating
iteratively time and time again.
This comes back to nightmare disorders.
This therapy, image rehearsal therapy, or IRT, will have you sit down with a therapist
and at first you will describe the nightmare that you're going through and you'll write
that narrative down. And then working with a therapist, you will agree to think about
a more neutral ending to that nightmare. So let's say that I was involved in a very,
very difficult car crash.
It was just horrific.
And every night since, I'd say at least once a week,
I just continue to have the nightmare of the car crash.
I know that I'm traveling towards the junction.
I apply the brakes.
The brakes have failed.
I am just looking around. I'm trying to maneuver,
but nothing is going to change this.
I go through the red light and someone side swipes me
and that's the end.
And I relive that time and time again, and it's awful.
So you with the therapist or I with the therapist
would then start to say,
well, what about the alternative scenario?
I depress the brake and the brakes don't work.
But gradually I think, well, I'm just going to reach over to the handbrake and I'm going
to gradually apply the handbrake.
And that slowly is going to bring the car to a nice safe stop.
And then I'm going to call the emergency services.
The car is going to get towed, I
don't go through the junction, I survive, everything's fine.
So you rehearse this alternate ending and you keep going through that, rehearsing that,
and then you go to sleep the next night and you'll probably have a high chance of that
nightmare again.
But if you keep doing that, once you've got that alternative ending, essentially what
you're trying to do is every time you reactivate the memory of the trauma car crash, and then
you rehearse this alternate ending, it's like me going into the Word document and editing
the section that was really horrific and bad and
replacing it with something that's neutral or even positive.
And over time, then I sleep and I will consolidate that memory and I'll come back the next day
and I'll do some more editing and more updating.
And time after time after time, gradually, you dissipate the narrative that is fixed inside
of the brain and the nightmare frequency decreases in proportion.
Now it's not effective for 100% of patients.
If you look at the data on average, it's about two out of every three people.
So about 66% of people will benefit, which if you look at some medical treatments, that's
a great
treatment.
That's still very effective.
There was a very recent study from Sophie Schwartz and her colleagues at the University
of Geneva that did an even more ingenious study, and they were able to nudge the effectiveness
of that treatment from 66% up to 92%.
And they used an additional memory-related research tool we've come up with in sleep
science, and it's called TMR, or targeted memory reactivation.
And here's how it goes.
I'm going to have you learn a set of associations.
Have you ever played that card game,
I think in America it's called Memory,
which is very apt, where you get a deck of cards
and it has two of the same item, two houses, two cars,
two fire engines, two kettles, and you shuffle the cards
and then you put them face down in a big square
and a big matrix and over time you have to turn over one card and it's a kettle and then I'm just going down in a big square, in a big matrix, and over time,
you have to turn over one card, and it's a kettle,
and then I'm just going to randomly pick another card,
and it's a fire engine.
Okay, but gradually you start to learn
where each one of the PURs are located.
So what's clever about that is we would do that type
of what's called a PURD association memory
test.
You learn these PURD associates and then we test you after a night of sleep and you're
better.
However, if for as you're turning those items over, I play a congruent sound.
So let's say you turn over the fire engine, and then when you turn over the other fire engine,
I'm going to start playing a fire engine noise
in the background.
So I'm bonding the association of the memory card purrs
with this tone, with this congruent sound,
and then a kettle, I turn over a kettle,
I turn over the other kettle, and it's whistling.
And then when you let people sleep at night,
if you start replaying those same tones
at a sub-awakening threshold,
so you're not waking people up,
and you bring them back,
and let's say that you only do those sound cue reactivations
for half of the memories that you've done
and the other half you leave untouched.
So within an individual, you have a unique, within individual control, for half of the memories that you've done and the other half you leave untouched.
So within an individual, you have a unique,
within individual control.
You test them on the things that you didn't reactivate
at night and those that you did.
It's almost like creating a bespoke playlist at night
where you say, look, I learned all of this information
during the day or wouldn't this be wonderful?
And then here's the stuff that I really think,
personally to me, I want to remember.
Well, it turns out I'd been tagging that
with particular music, and then at night,
I replay that music and the next day,
it turns out that those things I reactivated
are much more strongly consolidated by way of sleep
than those things I didn't.
So that's the basic method of what we call TMR,
targeted memory reactivation.
What they did was something very clever.
They had them go through this process
of the image rehearsal therapy.
They were rehearsing the alternate ending,
but about every 10 seconds, they were playing them
this very pleasing piano chord in the background.
And they were just bonding the association of the new outcome ending to the nightmare
with this pleasant piano chord.
And then sure enough, in the subsequent weeks afterwards, not only was that person day after
day doing the diligent therapy practice of rehearsing the memory whilst the piano tone was playing.
But then at night, they would wait until they went into REM sleep, which is the state we
think the emotional therapy begins, and they would start to replay that same piano chord
over and over again.
And sure enough, those people who had image rehearsal therapy standard, they improved
by about 60% in their nightmare frequency reduction.
Those people who did that plus the memory reactivation at night, it drove it from 66%
all the way up to 92%.
So now modern day neuroscience with its techniques is starting to overlap with classical clinical psychology.
And we're developing these next forefront of methods that really harness and fine tune
the brain's ability to undergo effective therapy.
It's incredible.
I mean, I think that we've known about classical conditioning for a long time and the, you
know, the, the case of Pavlov's dogs
is the most known of those.
Am I right in recalling that this paired association way of bringing about certain memories or
strengthening certain memories in sleep can also be accomplished with odors?
That it's not just the playing of tones during specific
experiences, but also, for instance, if one were to pair a
particular odor with a certain novel memory event in the daytime
or attempt to learn something new, that if that odor is then
infused into the room of the sleeping person later that night,
that somehow the memories would be strengthened? Do I have that correct?
There's nothing wrong, I've said it before, I'll say it again, there's nothing wrong with
your memory.
That was one of these seminal papers that started this whole movement.
And what they did was they had them learn this kind of herd associate card test, but
they were wearing this mask, it almost looks like a fighter pilot mask.
And they were either puffing up inert air
that didn't smell at all,
or they were perfusing this very pleasant rose scent.
Because smell in particular has a very unique relationship
with our memory, in part because we emerged
from animals that would principally use smell
as their navigational tool.
I think everyone has had this experience
where you bond a certain cologne or a certain perfume
with a particular individual.
So they were puffing the rose perfume
up the nose of these participants.
And then when they went into sleep,
they started to re-perfuse that rose odor.
Now, what was clever also about the experiment, you could say, well, look, just any time you
get something that smells puffed up your nose, your memory is going to be better.
Now the initial experiment had them learning the information when they're awake with the
rose scent getting pushed up their nose.
And then when they slept, they had the rose odor again. Another group had learning, but they had no rose smell pushed up their nose to bond with
the information at the time of learning when they were awake.
And then when they slept, they also had rose odor stuffed up their nose, and they showed
no additional benefit.
So it's not just enough to have rose odor at night.
You need to have made the initial bonded familiar connection
with the novel information that you're learning
to get the subsequent targeted memory reactivation benefit.
And you could then think, well, practical tools, what should I do?
Maybe when I'm learning for studying for a test,
I should blaze up my most preferred incense.
And I have a particular proclivity to green tea incense,
it turns out.
And maybe then before I go to bed at night,
I get a couple of sticks and I blaze them back up,
took my head on the pillow, turn the light out.
However, do not do that
because it's probably a desperate fire hazard.
So do not listen to me.
But you could think about doing something along those lines perhaps.
Anyway, so that's targeted memory reactivation.
Yeah.
It's a perfect segue for what I wanted to talk about next, which is lucid dreaming.
But before we move to lucid dreaming, I'm wondering whether or not there's an opportunity here
to construct an experiment, maybe even a protocol of sorts,
to uncouple the negative experience of nightmares
to our daily experience.
So for instance, we're talking about paired association
based on odors or sound replayed in sleep
to sort of nudge or conjure particular daytime
memories to the surface in the form of dream sleep.
Yeah.
But we also know that one can uncouple associations.
So for instance, if one experienced something negative, maybe this is being attempted in the realm of trauma therapy,
and that experience was paired with a particular odor,
it'd be hard to do with visual cues in sleep, or sound.
Could one attempt to introduce a sort of a competing sound,
set up a sort of a competing sound, you know, set up a sort of a collision stimulus
so that in sleep, the dream would no longer contain
the scary content or it would be less scary.
Or is this exactly the wrong approach?
Because if we believe that the nightmares
are serving some functional purpose,
allowing us to work through.
What you really don't wanna do.
Right, okay, great, allowing us to work through. What you really don't want to do. Right.
Okay, great.
Then we answer the question.
Well, no.
I think it's unclear right now, but you're on the right line because there is something
that we have in learning and memory called fear extinction.
And let's say that I were to sort of classic Pavlovian learning, Pavlov's dogs.
Let's say I show you a specific image on the screen and then you hear a specific tone and
then you get an electric shock.
I show you the stimulus on the screen, you hear the specific tone, and then you get an
electrical shock.
But I don't show you the stimulus on the screen, but you do still hear the tone and then what happens is that you have a braced response to the electrical shock.
And there's all sorts of combinations in between of that.
But essentially, I condition you to learn that these things seem to be associated with
a negative outcome, the inverse being the Pavlovian dog, which is that you ring a bell,
you show the dog some food and it salivates. You ring bell, you show the dog some food and it salivates.
You ring the bell, show the dog some food and it salivates.
And then you ring the bell, you don't give it some food and it still salivates because
it knows that the bell precedes the meat being shown.
And I actually mixed my order around there in my own experiment to begin with.
But then there's something different that you can do.
You can start to perhaps change the sound
or the bonded connection,
and then you don't start getting the shock anymore.
So that same ringing of the bell now
is no longer consistently associated with the food,
and gradually you decondition the dog,
such that after some time it learns,
oh, I started to learn that the bell predicted food,
but now it no longer does,
and it takes some time to remove that,
and that's what we call extinction.
You've induced an association,
and then you've gradually extinguish it
by way of that alternate training method.
So the question then became, could we use that type of method, but during sleep, could
we train you up on a fear memory and then just begin the early signs of extinguishing,
of deconditioning you?
But then we don't do that very much.
We wait until sleep and we continue the deconditioning protocol and
Sure enough sleep seems to be as if not more effective at
Extinguishing those fear memories than when you enact the protocol during wakefulness
So here is a very good example of where you can use this sleep dependent memory processing
tapestry, this opportunity to harness not just to strengthen memories that you wish to keep, but start
to extinguish memories you wish to remove.
And so I think it's a very exciting, it's right on the cusp of what we're starting to
do right now.
But I love it because I think some people would like to experience certain dreams and other people would like
to not experience certain nightmares,
which reminds me of a tool that Rick Rubin taught me.
I don't know of any experiments that support this directly,
but I've tried this and it certainly has worked
first time and every time, which is Rick said,
if you wake up from a dream and you want to remember your dream
and or you found it pleasant or interesting, lay there completely still with your eyes
closed and it will come to you.
Whereas if you wake up from a nightmare, which many people do, and in a state of anxiety
and you have a hard time kind of shaking the disturbing affect associated
with that nightmare to move your body,
get up and move your body and maybe even flip some lights
on something that normally I don't suggest
in the middle of the night.
But waking up from a nightmare can be quite disturbing
and it can be disturbing enough that it makes it difficult
to fall back asleep.
So, and by the way, he's right.
I don't know if he's by the way, he's right.
I don't know if he's read the science or he's just,
knowing Rick, he's probably just because he's so Yoda-like,
he's probably intuited.
Yeah, his supernatural levels of insight.
Tens of thousands of scientific articles,
but he's absolutely right.
One of the ways if you really wish to remember your dreams
is not just jump up out of bed
and start trying to write them down.
Don't.
Lie in bed, keep your eyes closed, and gradually rehearse that dream over and over in your mind,
almost as though you're scoring it into the etched surface of your memory trace more and more.
And gradually, when you've re sort of capitulated
and piece back the jigsaw puzzle,
then gradually open your eyes, start to dictate,
start to write down, but don't do it immediately
because as soon as you start doing it,
it begins to float away, it begins to dissolve
in a way that's, you're sort of, you know,
you're running and you're trying to reach your hand out
and grab them.
It's like fakers,r, it's like fog.
Exactly, yeah.
That's why I use the voice memos.
Last night I woke up in the middle of the night from a dream
and I decided to turn on voice memos.
And I remember thinking, I'll remember this in the morning
and I remember, you never remember this in the morning.
Oh, Contra.
That is a perfect segue for lucid dreaming,
which is the awareness that we are dreaming well in a dream.
Is lucid dreaming real?
Can we train ourselves to lucid dream?
And what is the value of lucid dreaming?
Is it just a fun game we can play?
Is there any reason we should attempt to lucid dream if we don't already or encourage more
lucid dreaming?
Or even any reason we shouldn't, perhaps.
Lucid dreaming, you beautifully gave the definition. Loosely defined lucid dreaming is that
you simply know that you're dreaming whilst you are dreaming.
So in other words, as the dream is unfolding,
you gain awareness of, ah, this is a dream,
but I'm still dreaming.
At that moment, by science definition,
you are in a state of lucidity.
But most people don't really mean that when they say,
I'm a lucid dreamer, they mean, yes, I become aware
that I'm dreaming as I am dreaming.
And then I take over the reins of control,
and then starting to decide exactly what it is you dream
and how you dream.
So now I'm on the ground and I'm walking through a park
and I decide that I just want to take off
and I want to fly over the river
or I want to fly out over San Francisco Bay and take a tour.
So I decide to start flying.
That is what most people think of as lucid dreaming.
If you were to think about it,
this thing called dreaming as we've described,
is utterly absurd as a state,
based on its psychotic kind of nature and characteristics,
to then start to say, it's that idiotic and strange
and bizarre, but PS, I can also take control of it and decide what I want to do with it,
injects a whole dose of disbelief into a process that's already unbelievable by itself.
So science for a while just thought, this is charlatan type stuff that these people claim
that they can control their dreams.
How can you ever prove that?
Because don't forget, when you go into REM sleep
and you dream, you are paralyzed.
So I can't just wake up and say,
I was lucid dreaming, that's not proof.
I have to in some ways be able to demonstrate that I'm lucid dreaming as I begin to become lucid,
but I can't because I can't communicate with you as the scientist.
Well, it turns out that you can.
One of the things we spoke about in the first episode
is that, yes, you get these rapid eye movements,
but think about what that means.
I told you that when you dream,
your brain paralyzes all of your voluntary muscles
so that you can when you dream, your brain paralyzes all of your voluntary muscles
so that you can dream and dream safely
and you don't act out your dreams,
with the exception that at least two muscle groups,
your extraocular muscles that move your eyes
and your inner ear muscles, for some reason,
they are spurred from the paralysis so you can still move,
otherwise you could never have rapid eye movements.
So the eyes, all of a sudden, because we have electrodes
up top and below and left and right sides,
we can measure what you're doing with your eyes
during sleep.
In fact, we have to do this to determine,
are you awake or are you in REM sleep?
The brain activity by itself doesn't tell us that.
We measure your muscle activity,
and if you lose muscle activity,
and your brain is very active,
and the eye channels that we're recording
start to show these darting back and forth signals,
we know you're in REM sleep, that's how we define it.
So that then suggested to us,
we can use the eye movements to create a form
of Morse code signaling
from the participant to the experimenter.
And so let's say that with this claimed lucid dreamer
who comes to my sleep center,
we'll create a very specific greed upon code,
which is that as you start dreaming, I can see that.
And when you become lucid in that dream,
firstly, give me three leftward flicks of your eyes.
We never see that in dreaming.
It's a very deliberative act.
And then when you say, OK, I've started the lucid dreaming,
and you've agreed with the experiment
that you're then going to start moving your hands,
you're going to start to move your right hand. Well're going to start to move your right hand.
Well, when you start to move your right hand,
give me four flicks to the right.
And when you're moving your left hand in the dream,
give me four flicks to the left.
And so there, we create this very specific instigational
code.
But then how does that help us? Well, we can have you sleeping in a brain scanner.
And before the brain scanning session when you sleep, I have you just go into the brain
scanner awake and I say, move your left hand and your right motor cortex is going to be
lighting up. And then I'm going to say, move your right hand, and your left motor cortex is going to be lighting up.
And for you and me, I build up a very unique map
of your left hand motor memory representation
and your right hand motor memory representation.
And if it's the left hand, as I said,
it's the right side of the brain.
If it's the right hand, it's the left side of the brain.
So now I've got ground truth
as to where your hand representation is on your motor cortex in my brain scanner.
And then I'm going to put you back in the brain scanner,
let you go into sleep, let you start dreaming.
Then you give me three left flicks.
Good.
This person has now become lucid.
And now he's doing four rightward flicks,
which means he's clasping his right hand
over and over again.
And then he gives me four leftward flicks,
which means he switched over.
He's now using his left hand in his dream.
By the way, I'm looking at the participant
inside of the brain scanner through the glass.
And of course, they're not moving their hand.
Why?
Because they're paralyzed.
But in the dream, they are claiming, based on their eye movements, that they are moving their hand. Why? Because they're paralyzed. But in the dream, they are claiming, based
on their eye movements, that they are moving their hands. We bring them back out of the
brain scanner and we analyze their brain scans during the period when they said, I'm moving
my right hand, I'm moving my left hand. What did we see? Sure enough, we saw the same,
we being the royal we, it's a great study by a German group. Sure enough, you see exactly the same pattern.
It was scientific ground truth evidence
that when a lucid dreamer claims
they are doing something in their dream,
the brain scans that we received confirmed
that indeed that's exactly what was happening.
It's just that none of the signal is being sent out
to the periphery, to the limbs, because there's that- Cut off at the spinal cord. that's exactly what was happening. It's just that none of the signal is being sent out
to the periphery, to the limbs,
because there's that-
Cuts off at the spinal cord.
Descending inhibition.
Yeah, at the level of the alpha motor neurons
of your spinal cord.
Incredible.
So here we are talking about lucid dreaming,
which is a kind of mixed level of consciousness.
Dreaming, of course, but also lucidity.
That is an awareness that one is dreaming.
Now, in just about every one of the five episodes leading up to this six episode in this series,
you emphasize the key importance of deep sleep and rapid eye movement sleep.
In many ways, some of the problems that arise from waking up in the middle of the night
too many times or being
in shallow sleep as opposed to deep sleep.
Lucid dreaming it seems is a kind of a case of light sleep because of one's awareness
or is it?
So that's the first question.
And then just very quickly an anecdote, when I was a kid I used to read these like Boys
Life magazines and those kinds of things.
I forget what they're called, but in the back they would have these ads for products like
x-ray glasses or sea monkeys, which turned out to be Brian Shrimp.
What a disappointment that was.
I thought they were monkeys.
On the package they were little monkeys, but they were Brian Shrimp.
There was a product advertised that I in fact purchased, which was an eye mask that had
a little blinking red light in one corner.
It said, learn to lucid dream.
The idea was that you would put this thing on and look at the red light just prior to
going to sleep, and then you go to sleep with this thing on.
Then at some point in your sleep, you would see or think that you saw the red light flashing.
And the idea was that because you were in the eye mask, you were in enough of a dream
that you would be able to link the waking state recognition of the light, et cetera,
et cetera.
Okay, people get it.
I purchased that product.
I used it.
I thought perhaps there was an effect, quote unquote, where I could lucid dream,
but I wouldn't consider myself an avid lucid dreamer,
although sometimes I am aware that I'm dreaming,
and usually it's in pleasant dreams,
in which case I'm usually like, yeah, let's keep this going.
Things like flying and being particularly talented
in a sport that in my waking life I had minimal talent,
things like that. Okay, so is lucid dreaming a case of shallow sleep particularly talented in a sport that in my waking life, I had minimal talent, things
like that.
Okay.
So is lucid dreaming a case of shallow sleep and therefore something to avoid or is lucid
dreaming something quite different?
And is there any advantage to learning to lucid dream or enhancing one's amount of lucid
dreaming?
And if so, how should one go about that?
So I'll take the question, should you be lucid dreaming?
And I think I can argue it both sides right now,
and we don't have a very clear answer yet.
The first side is if you take a step back
and ask from an evolutionary perspective,
let's assume for want of a better word,
that lucid dreaming is helpful,
it's meaningful, and that we should engage in it.
If that's the case that it confers some type
of evolutionary benefit, then you would expect
that a lot of people would be doing it.
But if you look at the statistics,
somewhere between maybe just 10 to 20% of the population
are natural lucid dreamers. And so from an evolutionary perspective, I could say, well, if it was so powerful, it
was so meaningful, because we know everyone sleeps, and for the most part, we can say
that almost everyone dreams.
If that's the case, then those must clearly serve a purpose.
But the fact that very few people are lucid dreamers,
doesn't that tell us that it isn't necessarily beneficial?
So from that perspective, I can play those numbers.
There is an inherent flaw in my argument there, however,
because that assumes based on the argument
I've just given you you that we have stopped evolving
and of course we have not.
And so perhaps that 10 to 20% of the population
who are natural lucid dreamers
are at the forefront of hominid evolution.
And they're the next super rate.
We shouldn't be worried about AI.
We should be worried about the lucid dreams
because they're gonna come and take over the wealth.
So I can argue it from that perspective,
which is just a philosophical argument.
It doesn't have weighted data to it, but there is some data.
Some individuals have asked the question,
is there any changes to your sleep
or even the benefits of sleep
when you are a lucid dreamer versus not?
And what's interesting is that for some papers
that have been published, after nights
when people report lucid dreaming,
they wake up and they don't feel as restored,
they don't feel as refreshed by their sleep in the morning,
suggesting just as you sort of hinted at there,
that the lucid dreaming state is associated with perhaps
a less deep or more shallow form of REM sleep,
or a more active state of REM sleep, perhaps too active,
so that it's fatiguing and depleting, and upon awakening,
you don't get that memory and that body, that
brain and body reset.
There are, however, a few papers that have not found that result.
So I think right now we don't truly know if the lucid state is associated with unrefreshing
sleep and unrestorative sleep.
But if that proves true, then I think that that's one argument.
The other argument I would put forward against it
from that perspective would be,
think about what we've said regarding
the functions of dreaming, memory processing,
but particularly emotional therapy
to gift us mental health.
If we then come along and say, presumably,
nature through millions of years of evolution
has come up with this blueprint manifesto
of exactly what should be served up
on the dream menu this evening.
That's, there's a reason for that.
And that reason has been sculpted over millions of years to become wonderfully optimal for
us and our emotional mental health.
And then we come along in the space of a lifetime, and perhaps you could argue a little bit humoristically,
we think, I perhaps know a little bit better than a couple of million years
of evolution.
I'm going to push those things off the rank ordering chart of what gets served up into
my dreams, and I'm going to supersede that and decide what I would prefer to be dreaming
about.
And again, I think that there's no good evidence that you could argue that that isn't true,
but equally that it
is true.
We just don't know yet.
If that is the case that lucid dreaming does produce unrestorative sleep, in some ways
it also begs the question, well, what is happening in your brain during lucid dreaming?
Is there anything in your brain that would explain why you don't feel refreshed?
An early study is looking at lucid dreamers when we put them inside of a brain scanner.
I told you at the start of this episode, dream sleep has a unique brain signature.
Memory regions, emotion regions, motor regions, and visual regions, they're all lighting up.
But then there's this one part of your brain that does the opposite, which is the lateral
left and right sides of your prefrontal cortex, the logical, rational thinking, controlling
regions of your brain, those go offline.
But early studies demonstrated that the activity, including the electrical activity over those
frontal regions, would be down as you were
in non-lucid dreaming.
But then when people rise back up and said, now I'm lucid dreaming with those leftward
flicks, that activity was brought back online, which makes a lot of mechanistic sense, which
is all of a sudden the part of your brain that prevented you from having rational logical control has been re-engaged
and as a consequence, you yourself can re-engage
in volitional dictation of the outcome
of what you're dreaming.
Some studies, however, have not replicated that finding
because when they looked at it and they took out some
sort of what we call these covariates
or these confounding factors,
and I can bore you with what that principally is,
it removed that result, and all of a sudden
the prefrontal cortex went back to seemingly being non-active.
They did find an alternate result.
What they found is that the electrical activity
of the brain when you go into a lucid dreaming state
seems to be a bit more frenetic, a bit more active
versus non-lucid dreaming states
of electrical brain activity.
And if that's the case, if the cortex,
which is already active, is forced to become even
more frenetically active when you are in this lucid dream state, is that part of the reason
that when you wake up from the lucid dreaming and you go about your day, your brain just
doesn't seem to be at the same operating ability because it's been fatigued above and beyond. It's like saying I do a standard workout and I always go to one or two reps before failure.
But now as I'm lucid dreaming, I am constantly going to complete muscle failure.
And then the next few days, if you go and do a workout, and I've been listening, you
and I have been trading workouts.
I don't want to do an Andrew Huberman workout, trust me.
You are, this man is.
Mine are short and sweet.
Well, we'll work out at some point together,
but it's almost as though then, no big surprise,
that after you do a leg stay,
if I were to wake you up the next day
and say you're back doing legs,
you say, I can't do that.
I'm toast, I'm hoarse, my legs are done.
And that's what we think could perhaps explain
why you get that fatigue.
Does that make some sense?
Makes very good sense.
And in the absence of better language to put to it,
I've long thought that one of the best things about sleep
is that we are not engaging our frontal cortex
that much in sleep.
As we talked about in an earlier episode, the frontal cortex during waking is responsible
for things such as the suppression of reflexes.
It has to do that according to context of a situation.
It's a lot of work.
The frontal cortex does a great number of other things as well, but I think one of the most wonderful things about sleep is that we get release and a break from all of that
analysis of duration, path, and outcome.
How long is something going to take?
What path do I need to take in order to get there?
What's the outcome going to be?
All that analysis of things, past, present, and future, it's work.
It's mental work. And I think that if you tell me, and I think you just did, that lucid dreaming involves
any kind of encroachment of duration, path, outcome type of analysis into my sleep, my
personal preference is going to be to not lucid dream.
I'd rather just have very robust, perhaps, you know, dreams of different kinds and try
and make sense of them once I wake up.
It's so tempting though, isn't it?
Because like you, I've had those experiences.
I remember an amazing dream where I was snowboarding
and I am a below average snowboarder.
And all of a sudden, I was just taking jumps
and I was doing all sorts of X game.
You're Sean White.
I was Sean, and it was unbelievable.
And I felt so, and I was so happy in the moment.
And I remember waking up and just thinking,
firstly, I'm sad I'm waking up.
Right.
And second, that was sublime.
And all I want to do tomorrow night is go back
and now I'm gonna switch my snowboard out for a dirt bike
and I'm gonna do the dirt bike X Games version of it.
I'm gonna be doing all sorts of Superman poses.
Can't get greedy with Mother Nature.
I know, I know.
She body slams you.
I get it, I know if people out there are enjoying it
or wanting to do that.
And by the way, I didn't answer, I'm so sorry, your red light question, you know, enjoying it or wanting to do that. And by the way, I didn't answer,
I'm so sorry, your red light question,
which is if you wanted to do it,
how can you do it if you're not doing it already?
There are, in fact, two scientific methods
that have been developed.
One of them actually has a vague whiff of relationship
to the light device,
although that's one of those things where if, you know,
if a friend sent it to me or a random person said,
oh, Dr. O'Graft, I've seen this in the back of a magazine.
Do you think it works?
I would just say, please go and spend your $199
on something that is going to be-
Yeah, I think it was about 11 or 12 years old.
I think it cost something like, I don't know, 10.99 or something,
which at the time for me was a lot of money, but I had a paper route.
I had a paper route back then and I had a little bit of a dispensable income.
But it was cool because it was probably one of my first experiments.
I've been running experiments since I was a kid,
but I think self-experimentation can be fun provided it's safe.
Oh, it's great. And you can see that.
But sorry, coming back to your red light,
the two methods, one of them is something
called the mild technique, which stands for
the mnemonic induction of lucid dreaming, M-I-L-D.
Mnemonic just meaning a memory based technique.
Induction, obviously what we're trying to induce something.
And what is it?
We're trying to induce lucid dreaming.
And it's a very simple technique, which is that you consistently rehearse before bed
this notion that I will remember my dreams and I will instigate control in my dreams.
And you do this, and it sounds just so hokey and non-scientific.
Sure enough, you do this over and over again,
the probability that you will lucid dream increases.
I think the better one,
the maybe the more effective one
is called the reality testing method.
And it was probably made famous in a brilliant movie.
If you haven't seen it, everyone should watch it.
It's called Waking Life,
and it is an amazing Richard Linklater, the director.
Just for the philosophy alone in it,
it will blow your mind.
It's exceptional, but it's a beautiful treatise
on dreaming and lucid dreaming.
And in that, they describe a method
where during the waking day, you are constantly,
perhaps you can set an alarm,
and you're constantly reminded to go over to,
let's say the wall, and flip the light switch on and off,
on and off, on and off.
And sure enough, what happens, the lights go on and off.
Why?
Because it's the real world, and it complies,
and it's complicit with the laws of physics.
So you do this time and time again
and you start to train yourself that
at unique moments throughout your waking experience,
you always go over and you test some version of reality
or it could just be,
I'm going to press my hand into something solid
and this table is resisting my hand right now
as I'm pressing it and I just keep doing that.
And then at some point it becomes routine enough that you start to do that same thing
when you are dreaming.
But now when I press my hand against the table or press my hand against the wall, my hand
goes straight through the wall.
Or I flip the light switch on and off and the lights do nothing. And all of a sudden, that's my cue to say,
I'm not awake, am I?
I'm dreaming.
And therefore, at that point, I gain lucidity
and it increases the probability.
So those are the two methods that people have used.
And statistically, scientifically,
they do seem to have some degree of success.
I love it. I love it.
I love it.
I personally am going to opt to not encourage lucid dreaming
because I'm, you know, and myself,
because I'm working on getting my sleep deeper
and longer through the night with fewer waking episodes.
We will get that.
We will get there.
Using the tools described in the previous,
and this episode of the series
that we're doing here.
My sleep's been excellent at times, pretty good at other times, and lousy at others,
which I think makes me well qualified to talk about tools for sleep because I feel like
I've come at it from every level of performance.
Very much.
And by the way, shield and sword in hand, I'm right there by your side.
We'll make it happen. Don't worry. Well by the way, Sheldon's sword in hand, right there by your side. We'll make it happen.
Don't worry.
Well, thank you, truly.
Okay.
So sadly, we are nearing the end of this six-episode series, and here we are in the sixth episode.
However, last night before leaving the studio, I decided to put out a word on social media on X, AKA Twitter, and on Instagram,
asking people what questions they have about sleep.
And I made it very broadband, you know,
I said, ask anything you want about sleep,
Matt Walker will do his best to answer.
And of course, we had thousands and thousands
and thousands of questions.
And we're grateful for it. Let's push on through till dawn, which completely violates every one of the six episodes.
No, I'm kidding.
They'll benefit.
We'll struggle.
However, we were able to bin those responses into most frequently asked, most frequently
liked, et cetera.
While we can't ask every question of you, what I thought would be fun and very
informative for the listeners is to ask 10 of the most popular questions.
Fingers on buzzers, no conferring.
Here we go.
And these are questions for which I think they're practical answers.
And so we'll do this not in rapid fire Q&A, but in, let's just say, a bridged format. And then perhaps we have you back another time to answer more of the questions.
Before we get into these questions, I will say that many of the questions that were asked
by the audience in those comments were in fact answered in the earlier five episodes
of this podcast series with Matt Walker, as
well as the one that we held today on dreams and lucid dreaming.
If you don't hear the answer to your question here and you have a burning question, chances
are your question was answered in a previous episode, and all of those episodes are time
stamped in a lot of detail so people can navigate quickly to the topics most of interest to them.
So without further ado, questions from the audience.
First question is about best practices
for managing rumination and negative thoughts
when trying to fall asleep.
Meaning if somebody is ruminating
and they're having negative thoughts
when they're trying to fall asleep, what should they do in order to get past that and fall asleep. Meaning, if somebody is ruminating and they're having negative thoughts when they're trying to fall asleep,
what should they do in order to get past that
and fall asleep?
Short circuit.
You need to short circuit that situation.
And the way that you can do that
is through a variety of methods.
There are multiple methods for short circuiting rumination.
The first I would recommend,
and it's something I practice, meditation.
But really all of these that I'll describe
are about getting your mind off itself.
That's the biggest problem regarding anxiety
and sleep onset insomnia,
which is what I think this person is describing.
So meditation allows you, it's either guided
and you're speaking about what you should be doing with your breathing or relaxation guided meditations.
All of those stop your mind from being able to play on itself and go through that rolodex
of anxiety.
You can do breathing techniques.
You can listen to sleep stories.
You can do your own type of body scan.
Anything that you can do, and something we described, which seems to be a quite effective
method is taking yourself on a mental walk.
Close your eyes and a walk that you know intensely well with vivid 4K detail.
Replicate that to the letter.
I left foot on the first step, down the steps,
take a right at the driveway, up I go,
walk up the hill, look to the left,
the bay is out there, it's 5 p.m.,
the sun is starting to set.
That level of detail.
And usually when you do any one of these things,
the next thing that you remember
is that you're waking up in the morning
because you were
able to short circuit.
That would be the best advice.
Terrific.
And I must say the other night I woke up in the middle of the night and was having a little
bit of trouble falling back asleep and I used this mental walk approach and it worked very,
very well.
So thank you.
The next question is what is the best position to sleep in?
Best body position.
Best body position is probably the absence of the worst.
That would be your back.
And it's ill-advised mostly for people who snore.
When you are on your back, the likelihood of you snoring
and that airway collapsing entirely and you
having what's called a hypoxic event where you stop breathing entirely is significantly
higher than if you sleep on your side or on your front.
So I would say that for most people, if you know that you don't snore, if your partner
says, I don't hear you snoring, that's partial confirmation that you do not snore.
If you are curious, and everyone should be,
everyone should be curious as to whether they snore,
I would say download an app and we can link to it.
I have no affiliation with whatsoever.
I pay my money, I think it's like pennies on the dollar,
I can say $2 a month or something.
And it is called Snore Lab.
So the word snore and then L-A-B.
And you download it and it's an app, and it is something that you install on your phone,
and then you say start recording, and you place your phone face down,
and it listens to you all night, and it records your breathing.
Nothing more.
Can't know what you're doing or saying. Don't worry. There's privacy. But it assess records your breathing. Nothing more, can't know what you're doing or saying,
don't worry, there's privacy.
But it assesses your breathing.
And then it will show you a distribution
of your snoring throughout the night.
And it categorizes that snoring from quiet, no snoring,
to mild snoring, to moderate, to epic.
And it literally is like a Richter shock and you will see very clearly
if you are snoring or not. Worse still and impactful most is that you can go to those
spikes when you are snoring and you can replay it. And it is quite frightening to hear yourself
struggling for breath. If you see a confirmation of snoring
by way of that SnoreLab, go and see your doctor.
That is the best advice.
80% of people who have sleep apnea or snoring
or cessation of breathing are undiagnosed right now.
And it will take years off your life.
And when you get treated, it is transformational.
Patient once told me me when I got treated
with my Sleep App device,
I felt like I was 10 years younger.
It was almost as though,
and I'll remember it to the day I die,
it was almost as though someone came along
and wiped a fogged glass clear and I could finally see.
That was the transformation.
So my advice is if you think you are snoring,
stay away from back sleeping.
From sleeping on your back.
From sleeping on your back.
And even if you don't suspect you are a snorer,
just download this app,
you get a couple of nights for free.
Just do it for a couple of nights consistently
and then ask also by the way,
if you take on board alcohol and you have mild snoring,
it is very clear, I would be highly surprised
if on the nights that you drink you don't get a significant increase in your
score of snoring.
Terrific. The next question is why does my body wake up at 3 30 a.m. and I'm
presuming their mind as well no matter what time I go to sleep?
So to that question and we will have spoken about this
before, my first response is, how do you know it's 3.30?
And their response is, because I look at the clock,
that's the first problem.
Take all clock faces away from your site
when you are sleeping.
It is only going to reinforce it.
The second is that 3.30 can sometimes,
or if it's a consistent time, there's no sort
of special thing about 3.30, it's just for this person.
People wake up at very specific times, quite reliably so.
Part of that is because they're going through very reliably timed sleep cycles.
And every time we finish a REM sleep period, we wake up.
But it's normally very brief.
And the reason is because we've been in paralysis and the body needs to move.
So we wake up, we make a postural shift,
we move in our bed just slightly,
and then we go back to sleep.
It happens to us all.
For some of us, we will wake up and then we will stay awake.
And that's why it seems to be so religiously timed
to certain specific moments in our night.
But this other sort of individual mention, no matter what time I go to bed, I seem to
always wake up there.
That to me smells of a suggestion of reinforced learning, that you've woken up a couple of
times, you've checked the clock, and now you have taught your brain very quickly that I
always wake up at 3.30 in the morning.
And lo and behold, what happens is that
you start to do that more frequently.
The more frequently it happens,
the more times that you check,
the stronger that memory association becomes,
the more likely it is to happen.
Remove the clock face from the bed.
Room.
Terrific. Can we bank sleep or catch up on lost sleep?
It's a great question.
You can and you cannot bank sleep and it is directional.
So what we found is that for certain things such as let's, an immune vaccination or learning and memory.
If you are sleep deprived, let's say the night after learning a specific task, and lots of
people have done this, so you are deprived the first night after learning, and that first
night we know is critical for consolidating and saving those memories.
But then the next day, I don't test you in the way I would normally do.
Instead, I give you a full recovery night of sleep, or maybe I give you two full recovery
nights of sleep, and then I test you.
Do you show any evidence of a memory consolidation benefit?
And the answer is no, you don't.
In other words, if you don't sleep the first night after learning, you lose the chance
to consolidate those memories.
So their sleep in that sense is an all or nothing phenomenon.
If you don't snooze, you lose in that regard.
And there are other examples of that downstairs in the body.
That is what happens when you go into a debt and then you try to pay it back with later credit
and it fails.
You can't seem to do that with sleep.
So in that sense, sleep is not like the bank
in that direction.
You can't accumulate a debt.
And then let's say at the weekend
after short sleeping during the week,
see if you can pay off that debt
at some later point in time.
It doesn't work like that.
So for example, if I deprive you Andrew Huberman
of sleep tonight, let's say it's an eight hour opportunity,
and then tomorrow I give you all of the recovery sleep
that you want, and then on a second night,
third night, fourth night, do you sleep longer
those subsequent nights?
Yes, you do.
But you only sleep back about 50%, about four extra hours.
In fact, if you look at the data, it's usually less.
It's usually around two, so only about 25% of the eight hours that you lost.
So you are always running a debt.
And if that's the case, if you can't truly pay back your sleep debt and you're constantly
running that short sleep cycle, it's like compounding interest on the loan.
It just escalates dramatically.
And that's why I think we see that short sleep really does predict ill health outcomes and
early mortality the later and later in life that you go.
However, there is a different form of sleep banking.
I told you that here, you're going into a debt and you're trying to pay it off with credit
later.
What if you had the inverse?
Let's say that you are a doctor or a nurse or you are working in the emergency services
and you know that you have two nights where you're on nights and you're going to be probably
very busy and you're not going to be sleeping well for the next two nights and you're on nights and you're going to be probably very busy and you're
not going to be sleeping well for the next two nights, and that's going to be next Monday
and Tuesday.
And I'm currently on Wednesday in the week prior.
There is something that has been demonstrated called sleep banking, which is where I know
I'm going to go into debt.
So I sleep longer and I create credit to begin with. And then I
spend that credit as I go into debt. And it seems to lessen the impact of that debt. It
doesn't remove the impact entirely, but it does lessen it. So here it's the inverse.
I'm not going into debt and then trying to pay it off later, I build up credit and then I can spend that credit with debt.
So there is a form of sleep banking
that seems to be present,
but it's not the sleep banking that most people think about.
Does that make, I know it's very confusing,
but I tried to be clear about that.
No, I know you made it very clear
that you can buffer some of the sleep loss
that you anticipate,
but there's no retroactive saving of what you lost.
That's right.
What are some of the best practices for getting back to sleep
after waking up in the middle of the night?
There, I would say there are several things.
First, don't try too hard, because trying to get back to sleep and become frustrated
is very much like trying to remember someone's name.
Sleep is just like this, that the harder you try, the further you push it away.
And as soon as you stop, all of a sudden that name just pops back into your head.
And it's the same way with sleep.
Now, previously I've said, you don't want to spend a lot of time awake in bed
because you learn the association that your bed is the place of wakefulness.
And every time you come in at night, you're always wide awake and you don't
know why, despite having fallen asleep asleep watching television just 20 minutes earlier. The other suggestion however is
most people don't want to get out of bed it's dark it's cold I get it I
understand it. The other thing to do in this situation is enjoy the concept of
rest. So wouldn't it be wonderful if in the middle
of your working day someone said,
look, just come away from your desk now
and here is a beautiful calm bedroom.
It smells very nice, nice dim light.
I would like you to lie down.
No need to fall asleep, don't fall asleep.
Just lie down on the bed or on the couch and just rest.
For the next 30 or 40 minutes,
just have a wonderful, good old rest.
That sounds lovely.
And if you are struggling to fall back asleep
and you've listened to me and the idiocy
of what I've been describing over the past six episodes,
you could start to get very stressed and say, gosh, well, sleep is doing this and this and this.
And I'm now and it's been 20 minutes and I can't fall back.
You just get more and more stressed.
Instead take a different approach at that point.
Instead of if you, for the techniques that we've spoken about, getting your mind off
itself and we list them just now, and we've listed them in a previous episode. If none of those are working and you just can't catch it, don't worry.
Just say to yourself, you know what?
Tonight is not my night and he told me it's okay.
And it really is.
It's fine.
Tomorrow night is going to be a better night.
Tonight instead, rather than trying to force myself to sleep, I'm just going to lie here, maybe with my eyes open,
I'm just gonna rest.
I'm just gonna enjoy and not stress.
I'm just gonna enjoy a good old rest in my bed.
And once again, the next thing that happens
is that the sun has emerged, it's bright in your room,
despite the blackout curtains and your alarm is going off.
Because as soon as you relaxed out of the state of trying,
sleep came back in a resplendent way.
Terrific.
Someone asks, quote,
I used to be a great sleeper, but as I've gotten older,
and then they mentioned that they're 65 currently,
I find that I wake up much earlier than I did previously, and it's difficult for me
to get more than six hours of sleep.
What do you think is going on, and what are some remedies?
The first question I would want to ask is, how do you feel on six hours of sleep?
We can go from the, if you are impaired and you're struggling during the day, and this
person sounds as though they are unhappy with that six hours, then we can start to have a conversation.
What would that conversation sound like? I want to understand perhaps the reason
that you can't get back asleep and we'll begin these techniques that we've spoken
about for trying to get back to sleep. Let's say that you've gone to bed at 10
and you normally would like to wake up at 6 but you're always waking up at 4
and there's just nothing you can do.
At that stage, you just don't feel the sleepiness over you, weighing you down, and there's no
amount of these methods are going to help you.
You just have to get up.
We see this a lot in older adults.
Sleep late in the night is very fragile, much greater probability of them waking up in the
second half of the night and the last quarter.
It's also miserable because most older adults, the circadian rhythm shifts earlier.
I told you that as we go through our teen years, our circadian rhythm shifts.
It gets sort of pushed into the future and we like to go to bed much later and wake up
much later.
And then into older adults, sort of into adulthood, it drags back a little
bit and we find our sweet spot. But then as we get older, it starts to regress back to
what happened when we were children. We want to stay up late, but we can't. We go to bed
so early and we wake up early. Some regression happens as we get older. By the way, it's
the reason that there is the quote unquote early bird special in Florida where a lot
of people retire. It's the early bird special because most people are to bed by, you know, 9 p.m. and they want
to be eating, starting to eat at 4 p.m.
So how do you deal with that?
One way is you can use one of the four methods, the four sort of macros of good sleep that
we spoke about, QQRT, quantity, quality, regularity, timing.
Here I would say see if you can delay your bedtime
as best you can.
If your bedtime is 10 and you're normally waking up at six
but you're consistently waking up at four,
start trying to go to bed at 11 p.m.
Push, push, push as hard as you can
until you are so sleepy, you sleep.
And then it will take a couple of days to build up that sort of remembering from your
brain and the debt that to begin with, you'll go to bed now at 11 and you'll wake up at
four again and things are even worse.
But after a while, you're building up this pressure to sleep and all of a sudden you're
going to bed again at 11, but your brain thinks,
I have had four nights of now just five hours of sleep.
I'm not doing this anymore.
I'm going to sleep through until five.
You can keep moving your schedule later because when older adults are waking up at four and
they can't get back, it's also miserable because the rest of the world is asleep and the people
they want to engage with, have a social life, call the kids,
speak with their grandkids, they can't do any of that.
So it's a very difficult situation.
If those things don't work, you can also speak
to a board-certified sleep medicine clinician.
CBTI, cognitive behavioral therapy for insomnia,
which we've spoken about in this episode,
is also effective for older adults to help them stay asleep.
If that doesn't work and you don't like to think
about a psychological treatment, there are some medications.
People think I'm probably a bit anti-medication
because I've been very vocal about classic sleeping pills.
But there are some sleeping medications
that I think do show promise.
I'm not anti-pharmacology by any means.
One of them that's been shown to be effective for older adults is something called doxapin. some sleeping medications that I think do show promise. I'm not anti-pharmacology by any means.
One of them that's been shown to be effective
for older adults is something called doxepin.
And, and trazodone too, although there's some sort
of pushback a little bit by the community against trazodone.
And there's a new class of drugs that we've spoken
about in a previous episode called the Dora's,
the dual-orexin receptor antagonists, DORAS.
So I've spoken about three there,
trazodone, doxepin, the DORAs.
By the way, I'm a scientist, not a medical doctor.
This is scientifically descriptive,
not medically prescriptive.
Trazodone has perhaps been used more so, if anything,
to help people who struggle to fall asleep.
Doxepin, if you look at the data,
is a medication that's much more helpful for keeping people
asleep and including, and especially it seems, for older adults.
And there, it's lower dose doxapin.
I think if you look at the data, three milligrams and six milligram doses have been effective.
You can get it in pill form, although usually not in those doses, and you have to end up
cutting pills in half because it comes in 12 milligrams.
There is a liquid solution that is provided, and there I think the standard dose starts
at around half a milliliter, so you get a little syringe, and it's a one-millimeter
syringe, and you suck up that half a milliliter, and then you just put it in a drink in the
last half an hour before bed.
It's tasteless and it helps you stay asleep.
So there are a variety of different things you can do.
Just go try for rest and just give yourself the chance,
push your bed to a later time point.
You can also try cognitive behavioral therapy for insomnia
and you can speak with your physician
about some sleep medications.
Terrific. There were a good number of people physician about some sleep medications. Terrific.
There were a good number of people that asked about sleep and menopause.
One question was, quote, since entering menopause, I have not gotten a good night's sleep in
years.
I think this question dovetails with the previous question.
It could be age-related, right?
Could be directly related to menopause.
So are you aware of any specific treatments
that you haven't covered in the course of this Q&A
that are unique to menopause?
I think the answer you just gave to whoever
asked the question about how to get more sleep or better sleep
as one has gotten older.
You should probably handle the answer to this question, but what of the menopause specific
requirements for getting better sleep?
It is a huge problem in premenopausal and perimenopausal women and, of course, women
going through menopause. It's principally because of what we call the vasomotor symptoms of menopause,
which is to say these hot flashes where you just get sort of really for the body at least
quite extreme increases in temperature.
You get so hot and don't forget in our episode two we spoke about how you need to regulate
temperature and there's a very beautiful and complex relationship between temperature and sleep.
We said you need to stay cool to stay asleep, but here is a situation where when you're
asleep, you're not staying cool, you're doing the opposite.
You're getting warm, and that is the adversarial thermal situation for staying asleep.
So individuals wake up, and then they struggle to get back to sleep.
I would say, and we know the reasons why too, some of the other issues with sleep are problematic.
It has to do with some of the sex hormone changes.
And I think I myself have released a podcast on this specific issue.
And I won't go into the mechanisms as to why.
I'll speak about the treatments.
One treatment which is non-medication based is trying to make your bedroom cool, but also
using these smart mattresses.
Now I've spoken to Matteo, the CEO of 8Sleep, another fantastic product, and he has had
a huge amount of feedback from menopausal women saying that that cooling mattress
has been very helpful for their vasomotor symptoms.
So that's one method you can go down.
The other is a medication method.
And here I need to be very careful.
I'm going to speak about bioidentical hormone replacement therapy for menopause.
Now there is a lot of controversy.
Again, I don't have a horse in the race.
I would simply say if you want to think about this,
you have done a fantastic podcast on female health
and female reproductive health.
I know our friend, Petra Tia, has got a very clear stance
on female hormone replacement therapy
and the absence of fear one has to have
around the risk of breast cancer.
And if you listen to him, he will excise, or at least he has disabused, I think, many
people of the belief that that is a concern.
But it's a very personal choice.
It's a woman's choice.
No one but a woman can decide.
But I would say that when women have gone into bio-identical hormone replacement therapy,
one of the things that benefits is also sleep
because it brings back under control
some of these symptoms.
It reinstigates some of the renormalization
of aspects of reproductive hormones.
And those are things that can promote sleep,
which when they become absent through menopause
are causing sleep disruption.
Great.
Someone asks, what does it mean if I can remember my dreams?
Conversely, what does it mean if I cannot remember my dreams?
Does this have any reflection on my sleep quality?
Well, some of this was addressed during today's episode, but maybe just to give a short recap
response, how would you respond to this?
So I would say that just because you remember your dreams
or you don't remember your dreams,
let's say you don't remember your dreams,
many people will ask me then,
does that mean that I don't get REM sleep
or I don't get enough REM sleep?
No, absolutely it doesn't.
There seems to be no correlation between
how much REM sleep that you're getting
and whether or not you remember your dreams.
That's, I think, point number one.
Point number two is that there doesn't seem to be a strong correlation
between you remembering your dreams and the quality of the waking day
that ensues as a consequence of that dream-remembered sleep
from the night before versus dream non remembered.
The only time that we've got a little bit of data comes onto what we've spoken about
today, which is lucidity, which is a different sort of one up level of dreaming.
There may be there's some unrestorative sleep argument, but for the most part, I would say,
do not worry if you're not remembering your dreams.
It doesn't mean that you are not dreaming.
By the way, I've got a wacky theory.
It doesn't mean that you are also not storing those dreams
and being influenced by them.
There is something called implicit memory.
And it was long sort of held, you know, these versions of you
go into a movie theater.
And for very brief milliseconds of periods of time,
you're shown images of Pepsi cans or Coke cans.
And then during the intermission, you track people's purchasing of soda, and sure enough,
they will buy more Pepsi if they get flashed.
So we can actually embed implicit information into people, and it changes their behavior.
They have no recollection of the memory, but it's clearly there, and it's clearly influencing
the behavior.
What does this have to do with dreaming?
I have a theory of dreaming where people, and I told you, most of us forget most of
our dreams.
And we think when we forget those dreams have gone, they've evaporated from our brain.
What if it's not the case?
Have you ever had that experience where you are waking up and you know you are dreaming
and you just cannot capture it.
And you think it's gone.
That's it.
I've forgotten it.
And then two days later, you're in the shower, you're looking at the shampoo bottle and the
label all of a sudden just unlocks the memory of that dream and it comes flooding back.
As a neuroscientist, that tells me an important thing.
That memory is in existence, but previously it was unavailable.
This is the difference between availability versus accessibility.
The memory was available, but you'd lost the IP address to go and retrieve it.
Available, not accessible.
Now if most of our dreams are still always quote unquote implicitly remembered, but we always fail to have accessibility.
Those memories arguably, according to my theory, are always available.
They're always in our brains.
We just don't have conscious accessibility to them.
That doesn't change the fact that our dreams may shape a huge amount of our behavior implicitly.
And to me, that's a wild, crazy theory.
And someday when I retire, I'll do the study
and try and disprove it anyway.
Love it.
What are the key supplements for sleep?
And I just have to say, that's a huge topic.
That's an entire episode into itself.
Yeah, you and I should probably do intellectual jazz
on that at some point.
Yeah, we should do that.
But let's constrain the question a bit for sake of time.
What, if any, supplements do you personally take or recommend
to people with the understanding that many people perhaps
do not need supplements?
We never want to give the impression that that's the first line approach to dealing
with sleep issues.
Get your sunlight, get your darkness, get your QQRT right.
All of that, if it's mysterious to you, all of that is in the previous episodes of this
podcast series.
Assuming that someone wants to explore the supplement space. And what do you recommend?
What do you take?
And please here, I'm going to encourage you to not take
into consideration at all what I've ever said about supplements
for sleep, because I think it's actually most useful if people
get a tapestry of opinions.
Please, I'm just going to say that outright.
I don't.
Maybe you could say a little bit more about those
that you would recommend.
And I think they're going to probably overlap
because I already sort of know some of them, but.
Sure, I recommend, again, I just want to say that
never take anything or remove anything from your regimen
without talking to your doctor first,
but, and always, always make sure
that you're doing all the behaviors correctly first. But, and there's so many of them, and always, always make sure that you're doing all the behaviors correctly
first.
There are so many of them.
Don't eat too close to bedtime.
Get your morning sunlight on and on.
The supplements that I recommend when people ask for supplement recommendations specifically
are magnesium threonate.
It's more or less interchangeable
with magnesium bisglycinate.
It has a slight sedative property.
A lot of people are deficient in magnesium anyway.
And this is magnesium taken about 30 to 60 minutes
before bedtime.
The other one is apigenin,
which is essentially a derivative of chamomile.
Yep.
And then the third is theanine, which is known to have a mild anti-anxiety component to it.
The one caveat is that theanine can be problematic for people that have very vivid dreams.
It can often, people say that it makes their dreams even more vivid.
And so if you suffer from that or it's waking you up, then I suggest leaving out the theanine.
I actually recommend people start with just one thing and then see how it affects them
and then bring more in.
I'll put a link in the show note captions to the dosages that were contained within
a zero cost newsletter about sleep rather than list off dosages here.
And then people can link to that in the show note captions.
Those are the main three.
And then there's one other which, and I use those by the way,
most every night before sleep and it has improved my sleep dramatically.
The other thing that I sometimes use is 900 milligrams of inositol, which for whatever
reason has, I find, again, this is anic data, makes it easier for me to fall back asleep
when I wake up in the middle of the night, especially if I haven't eaten very many starchy carbohydrates in the
days preceding.
I try and eat some starches after hard training and things of that sort.
But sometimes if I'm on a lower carbohydrate regimen, then I find it extra difficult to
sleep so I'll throw in some inositol.
I will say there have been nights where I forget my supplements and just fall asleep.
And so it's tough to say exactly what each of those is doing and in what combinations
you always need to think about how much disposable income somebody has.
Again, get your behaviors right.
Get the do's and don'ts that Matt described during the course of this podcast series right
and then consider supplementation.
But that's pretty much what I rely on.
Yeah, I like what you're saying, both the philosophy of it too, because the things that
we've spoken about, the QQRT and all of the different methods, they are a log order magnitude
greater in terms of how they will course correct your sleep than probably any supplement effect
that I know of.
Absolutely.
But to go back to your MAG-T, MAG-3 and 8, I think there is some evidence, definitely
interesting evidence.
It was more so in older adults, and they were able to show increases in the total amount
of deep sleep.
I think it was somewhere around about 15% to 20%, although that's the relative percent
difference.
If you look, I think it was only about six or seven minutes of total deep sleep.
But there is some evidence there.
The evidence by way of you've heard the story of that magnesium is good for sleep, it's
principally derived from evidence of people who are magnesium deficient.
And when you make them magnesium normative, they start sleeping better.
That's a very different question than saying, I am magnesium normative, I am in in normal ranges and then I add to it, do I expect any greater benefit?
That's like me saying, you're at an oxygen saturation of 99.9 and I'm going to give you
pure oxygen.
It's not going to move you above 100.
You're already at ceiling.
Whereas if you are at 85% and I give you oxygen, you're going to get a lovely benefit from
that.
So, but I like MAG 3 and 8 because it is based on the evidence, the only one that does cross
the blood-brain barrier.
People have said, well, then why do I get a benefit from things like the other one that
I would speak about is probably slow MAG because it can be tough on some people's tummy and
it's a coated form of magnesium.
That doesn't necessarily cross the blood-brain barrier.
But magnesium, I would say,
if one to focus on would maybe be magnesium chloride,
that seems, maybe Petra Tira has released a podcast on this too.
That seems to be, I think, an effective one for bioavailability.
But if it doesn't cross the blood-brain barrier,
how can it be affecting sleep?
Because sleep is of the brain, by the brain, and for the brain.
One of the reasons is because of muscle relaxation.
So if you're too tense in your body, it feeds signals of stress to your brain.
And if you're stressed, as we've spoken about, you're not going to sleep well.
So I think there could be indirect effects of forms of magnesium that do not cross the
blood-brain barrier.
Again, assuming that you are magnesium deficient, I think epigen and chamomile has some good
evidence.
Valerian root, unfortunately, if you look at the data, it doesn't seem to hold up in
terms of any sleep benefit whatsoever.
Probably two that I would add to that list.
The first is glycine. And here we're talking about doses of maybe 1.5 to 2 grams of glycine has quite a reliable
robust literature.
Now, it's not randomized controlled trials of a level of a drug because these are supplements.
You don't get those studies.
But it does seem to have quite a reliable benefit based on what I've seen in the literature.
The final one I would say, which has very good data to support its action, is something
called phosphatidylserine.
And again, I've got no association with any supplement company whatsoever, but this has
been reliably demonstrated to tamp down the cortisol response.
Now that data you've got to be careful.
If you look at it and read the studies which I have, it's principally in athletes and they
use an athletic performance intervention to brute force cortisol to go up and then they
use this medication and it brings it back down, but it is reliable.
I bring this up because we spoke about in one of our episodes, insomnia patients, as
they're trying to fall asleep, cortisol is coming down just like it is in all healthy
people and it drops low just as we're about to fall asleep.
But in insomnia patients, it spikes back up again and then it does in the middle of the
night.
So here is a medication that one could try to try to tamp down that cortisol specifically
as you're going into sleep, and that may be of help
too.
So those are the only two that I would give with the same caveat that get everything else
straight.
Stop worrying about buying supplements and thinking it's going to be a quick fix.
Get the basics in place, and then we can think about fine tuning you for the final couple
of percent optimization that you get from supplements.
Terrific answer.
The final question of this sixth and final episode
of this podcast series on sleep with Dr. Matthew Walker.
I'm so sad, I don't want to leave.
I don't want to stop speaking about sleep.
We can always do another.
I would love to.
If the literature changes, it evolves,
we can do another and another is the following.
If you could give just one tip for getting better sleep,
what would that be?
Regularity.
Just keep things regular.
If you get regular sleep,
a lot of things will start to take care of themselves.
And after that, if they don't, we'll have another conversation.
We'll go back to the other three keys, the other three of the four macros of sleep, quantity,
quality, and regularity, as I've spoken about, and timing, and then all of the other protocols
that we've mentioned.
But start with regularity.
Get that straight. And I would also say your timing too,
the R and the T of QQRT.
Figure out your chronotype,
get good with your chronotype as best you can,
and then get regular.
If you do those two things,
sleep in synchrony with your chronotype
rather than against it,
and you are being regular weekdays and weekends, you will get
a long way to getting better sleep.
Fantastic.
Well, I'll put one in.
If you could give just one tip for getting better sleep, what would it be?
I suggest you listen to all six episodes of the Huberman Lab podcast guest series with
Dr. Matthew Walker about sleep and ways to improve sleep because episode one covers
the biology and the basics of how to get better sleep
and what sleep is.
Episode two gets into the more advanced tools,
although I think they are tools that everyone,
I know they're tools that everyone can
and should consider.
Episode three gets into the power of naps,
caffeine, food, and the timing of those.
Oh, so powerful. Episode four gets into the power of naps, caffeine, food, and the timing of those, oh, so powerful.
Episode four gets into the role of sleep
in learning memory and creativity.
What's more interesting than that?
Episode five, we discussed sleep and its impact
on emotional health and mental health.
And today we were discussing dreaming and lucid dreaming.
And here is where I get to say,
Dr. Matthew Walker, thank you oh so much,
oh so much for giving us a absolutely world-classed
grand tour of this incredible aspect of our lives
that we call sleep.
And in doing so, also making it extremely clear,
extremely actionable at every step,
and very, very thorough in a way that really honors
the interest and intellect and just real sincere interest
in this topic on the part of the audience.
So I could not think of a single better person for this series than you, alive or dead.
Fortunately you're alive.
And I just want to say on behalf of myself, everyone else here at the Huberman Lab podcast,
and the many, many millions of people listening to or watching this series, thank you ever so much.
For having me on, for giving me this opportunity,
firstly, thank you, but also for the generosity
of your heart, your intellect,
and your willing to disseminate knowledge
to millions of people, myself included.
It is my privilege to sit next to you, across from you,
and I've received so much wisdom and knowledge from you
as so many others have.
You are an international treasure.
Thank you, Andrew.
Thank you, I'll try and take that in.
I'm grateful for you being a colleague and a friend.
And my favorite sign off with people I love is more soon.
Take care.
Thank you for joining me for today's episode with Dr. Matthew Walker.
To learn more about Dr. Walker's research and to learn more about his book and his social
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