Huberman Lab - How to Improve Your Teeth & Oral Microbiome for Brain & Body Health | Dr. Staci Whitman

Episode Date: March 24, 2025

My guest is Dr. Staci Whitman, DMD, a board-certified functional dentist for kids and adults. We discuss the critical importance of oral care and the oral microbiome for brain and bodily health. We ex...amine the negative effects of common oral care product ingredients such as alcohol, astringents, and bleaches. We also explore the history and real impact of fluoridated drinking water on oral, bone, and systemic health. Then we discuss healthy, lesser-known solutions for bad breath, canker sores, cavities, and teeth whitening. We cover how teeth can be made to repair their own cavities and the connection between oral health and cardiovascular health, male and female fertility, dementia, and cancer. This episode goes far beyond the best approaches to brushing and flossing and will be a valuable resource for anyone seeking to improve their oral health and appearance at any age. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman BetterHelp: https://betterhelp.com/huberman Joovv: https://joovv.com/huberman Function: https://functionhealth.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Staci Whitman 00:02:04 Oral Health & Oral Microbiome 00:05:01 Oral Healthcare Ingredients, Sodium Lauryl Sulfate (SLS); Canker Sores 00:08:45 Sponsors: Eight Sleep & BetterHelp 00:11:38 Cavities & Teeth De-/Remineralization, Fluoride 00:19:14 Cavities, Tool: Meal Frequency, Fasting 00:21:51 Sugar, “Dissolvable” Carbs & Cavities, Tools: Feed the Rainbow, Clean Diet 00:27:41 White Teeth, Bleaching, Hydroxyapatite, Mouth Breathing 00:34:34 Antibiotics, Gut & Oral Microbiome, Tool: Probiotics 00:36:20 Mouthwash, Alcohol, Astringents, Cardiovascular Risk, Bad Breath 00:39:54 Sponsors: AG1 & Joovv 00:42:21 Saliva, Dry Mouth, Salivary Analysis, Tools: Hydration; Nasal Breathing 00:47:23 Mouth vs. Nasal Breathing, Hard & Soft Tissue Issues 00:54:19 Deviated Septum, Therapies, Kids & Adults, Mouth Breathing & Sleep Disorders 01:00:42 Gum Health, Flossing; Sexual Health 01:01:50 Shifting to Nasal Breathing, Mouth Taping, Tools: 3-Minute Test, Kiss The Sky 01:05:53 Chewing Gum, Mastic Gum, Tool: Xylitol; Chewing Food, Breastfeeding 01:11:28 Sponsor: Function 01:13:15 Gum Disease, “Leaky Gums”, Cardiovascular Disease, Dementia, Cancer 01:20:05 Antibiotics, Ozone Therapy, Oil Pulling, Mold, Tool: Coconut Oil; Facial Trauma 01:28:07 Nicotine Gum & Pouches, Oral Health; Coffee, Teeth Whitening 01:34:16 Whole Foods, Hydroxyapatite Toothpaste; Tool: Testing Oral Microbiome 01:39:39 Water Fluoridation, History, Other Fluoride Sources, Neurocognitive Issues 01:54:57 Drinking Water & Fluoride, Toothpaste, Cavities 01:59:51 Sponsor: LMNT 02:01:07 Water Fluoridation & Levels 02:04:52 Oral Health & Fertility 02:07:03 Toothbrushing, Flossing, Waterpik, Tool: Toothbrushing & Meals 02:13:23 Teeth Spots & Markings, Fluorosis, Hypoplastic Enamel 02:19:10 Oral Health, Women, Pregnancy, Menopause & Burning Mouth 02:23:16 Geographic Tongue; Lip Balm; Mouth Breathing, Symmetrical Chewing 02:27:09 Tongue Tie, Chewing & Speech Function, Intervention 02:32:27 Red Light Therapy, Peptides & Exosomes 02:34:40 Mercury Fillings, Ceramic Composites, Retainers, Sealants 02:39:08 Dentists, Depression, Anxiety, Suicide; Insurance 02:45:05 Recap, Top Behavioral Tools for Oral Health, Tongue Scrapping 02:52:10 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures

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Starting point is 00:00:00 Welcome to the Huberman Lab Podcast, where we discuss science and science-based tools for everyday life. I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine. My guest today is Dr. Stacey Whitman. Dr. Stacey Whitman is a functional dentist
Starting point is 00:00:20 with expertise treating both adult and pediatric patients. She focuses on oral health as a key feature of overall gut health and a powerful modulator of brain longevity, heart health, hormones, and fertility in both men and in women. Today, we discuss many of the common myths about tooth and gum care and how to use specific nutrition, breathing, and cleaning methods to repair cavities,
Starting point is 00:00:41 whiten teeth, and freshen breath, while at the same time, improving the oral microbiome. This is very important because as Dr. Whitman explains, most of the things that people do in pursuit of better tooth health and appearance and fresh breath actually damage their oral microbiome and indeed can lead to serious cardiovascular issues. So today we discuss how to brush, how to floss. I know we've all heard that we need to brush and floss, but Dr. Whitman explains exactly how to do those
Starting point is 00:01:06 so that they are of the maximum benefit for our tooth health, gum health, and oral health generally. We also discuss the signs and benefits of things like tongue scraping and oil pulling. And we discuss fluoride, which of course is a very controversial and timely topic nowadays.
Starting point is 00:01:21 It's a very interesting conversation that I believe everyone, young, old, parents, and kids need to be aware of. We also discussed treating things like tongue ties, deviated septums, canker sores, and more. By the end of today's episode, you'll have the most up-to-date knowledge about how to take care of your oral health, both for aesthetic reasons and, of course, to reduce cavities and gum disease, and in doing so, how to support your brain and heart longevity. Before we begin, I'd like to emphasize that this podcast is separate
Starting point is 00:01:48 from my teaching and research roles at Stanford. It is, however, part of my desire and effort to bring zero cost to consumer information about science and science-related tools to the general public. In keeping with that theme, this episode does include sponsors. And now for my discussion with Dr. Stacy Whitman.
Starting point is 00:02:04 Dr. Stacy Whitman, welcome. Thank you, Andrew. I'm super excited to talk about oral health from all perspectives. Your public facing content, especially on Instagram, has completely transformed the way I think about this thing that I call my mouth, that people think of as their teeth and their mouth and their breath and their tongue
Starting point is 00:02:27 and all this stuff as a key site for evaluating and maintaining health of my brain, my body. And today you'll make it clear as to why that's the case. I'd like to just start by looking at this oral health thing through the lens of what I think most people think of when they hear the words oral health, which is people want, it seems, whitish or very white teeth, depending on their preference. They want fresh breath, or at least to not have bad smelling breath.
Starting point is 00:03:03 And they want their mouth to sort of feel good, right? The question I have is, what are some of the things that many, many people do in trying to have white teeth, fresh breath that actually are very destructive for our teeth and our oral microbiome? And if we go through that entry point into this conversation, then we can get into some of the specifics of why that is. What's something that you see many people doing in terms of trying to have bright white
Starting point is 00:03:36 teeth that actually is harming their teeth? Sure. Great question. Great way to start off. I first want to commend you and thank you for including the oral microbiome and oral health as one of the pillars of health. That means a great deal and it has a lot to do with this answer. So unfortunately, we have been taught that we need to carpet bomb the mouth.
Starting point is 00:03:58 We need to add astringents and alcohols and foaming agents and really strong essential oils to clean, disinfect and to freshen the breath. But we're really, what we're doing with these products is damaging our delicate microbiome, which can make things far worse. So much of oral health is a less is more approach and it's not so product heavy. It should be more focused on diet and lifestyle, like anything with health. Unfortunately, dentistry has been separated and compartmentalized out of the body, like much of medicine.
Starting point is 00:04:32 You know, we were so specialized and subspecialized in dentistry is included in that. And we need to remember it's all interconnected and what we're doing to the mouth, whether it be strong toothpaste, mouth washes, certain gums, and even what we're eating and how we're breathing can really do a number on our oral health. And so it's taking a different perspective and it's a bit of a mindset shift to really
Starting point is 00:04:58 get us back to optimization. So do you think that most of the common over-the-counter toothpastes, while they smell minty or pepperminty and taste minty and pepperminty, are they effectively cleaning teeth? And are they causing any damage to teeth by virtue of what they have in them? It really depends on the ingredients. So I'd like people to start looking at their oral health care products. Like they're starting to look at food labels. We should be reading the ingredients and understanding why they're there and what they're doing,
Starting point is 00:05:30 where are they sourced from. But certainly, I think so many of us feel it has to burn and foam to be effective. What is tooth brushing? What is it really doing? You're disrupting the biofilm, which is really the plaque or the bacteria that are adhered to your teeth. And so all these extra bells and whistles, it's sort of extra credit, but if you're perfectly imbalanced, we shouldn't need all these stripping agents and strong mints and things.
Starting point is 00:05:58 So for example, sodium lauryl sulfate is a foaming agent, but it also can be really disruptive to the oral mucosa and can lead to oral ulceration. So that's a common ingredient that causes foaming that I would argue we do not need. Your toothpaste shouldn't foam, nor should it burn. Essential oils, we think, oh, those are natural, they're healthy, right? Well, many are very antimicrobial, and so they could be damaging the healthy bacteria in your mouth.
Starting point is 00:06:26 So that's where that strong burn after many toothpaste, you really don't need that. And if your breath is so bad, or you have halitosis that you feel the need for that, then I would argue, well, let's dig deeper. Why is your breath so imbalanced? There's probably something else going on. So I really encourage people to start learning about their products. I think we just give dentistry and teeth, we push it to the side. It's kind of an afterthought many times.
Starting point is 00:06:55 And just like we're prioritizing skincare, shampoo, things that we're putting on our bodies, we need to be focused on the ingredients in our oral healthcare products too. Especially since we're literally putting it into our body, not just on the surface of our body. What was the foaming agents again? Sodium lauryl sulfate. And the problem is there's derivatives.
Starting point is 00:07:15 So some cleaner versions might have coconut derived, SLS derivatives, and many people will do okay with those, but a common complaint I see in my office are oral ulcerations. The first thing I think of is what's in your toothpaste. Does it have SLS or a derivative? Because we're all different and some people have more sensitivities and will react more to those.
Starting point is 00:07:41 Are oral ulcerations canker sores? Yeah. Or are canker sores? Yeah. Or are canker sores? Apus ulcers, yes. So if one gets a canker sore, what does that reflect typically? Let's assume the toothpaste doesn't have anything to do with it. Is that a disruption in the microbiome? Is it from a physical injury like a bite to the gum?
Starting point is 00:08:01 It could be all. So it could be secondary to trauma, certainly. It can be viral related. So the herpes virus often will result in oral ulcerations. It just be one. Yes. But also, and this is off not on many people's radars, you know, the mouth is the gateway into the body and the mouth is the gut.
Starting point is 00:08:22 I want people to start thinking of it that way. So what happens in the mouth can be a reflection of what's mouth is the gut. I want people to start thinking of it that way. So what happens in the mouth can be a reflection of what's happening in the gut. And so a lot of times when I have patients that come in with recurrent apthous ulcers or ulcerations that can be a sign of Crohn's or celiac, IBS, like something going on deeper within that we need to be evaluating, food sensitivities, et cetera.
Starting point is 00:08:45 I'd like to take a quick break and acknowledge our sponsor, 8 Sleep. 8 Sleep makes smart mattress covers with cooling, heating, and sleep tracking capacity. Now I've spoken before on this podcast about the critical need for us to get adequate amounts of quality sleep each and every night. Now, one of the best ways to ensure a great night's sleep
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Starting point is 00:09:18 Eight Sleep automatically regulates the temperature of your bed throughout the night according to your unique needs. Now I find that extremely useful because I like to make the bed really cool at the beginning throughout the night according to your unique needs. Now I find that extremely useful because I like to make the bed really cool at the beginning of the night, even colder in the middle of the night and warm as I wake up.
Starting point is 00:09:32 That's what gives me the most slow wave sleep and rapid eye movement sleep. And I know that because 8Sleep has a great sleep tracker that tells me how well I've slept and the types of sleep that I'm getting throughout the night. I've been sleeping on an 8Sleep mattress cover for four years now, and it has completely transformed
Starting point is 00:09:46 and improved the quality of my sleep. Their latest model, the Pod4 Ultra, also has snoring detection that will automatically lift your head a few degrees in order to improve your airflow and stop you from snoring. If you decide to try 8Sleep, you have 30 days to try it at home, and you can return it if you don't like it,
Starting point is 00:10:02 no questions asked, but I'm sure that you'll love it. Go to eightsleep.com slash Huberman to save up to $350 off your Pod4 Ultra. Eightsleep ships to many countries worldwide, including Mexico and the UAE. Again, that's eightsleep.com slash Huberman to save up to $350 off your Pod4 Ultra. Today's episode is also brought to us by BetterHelp.
Starting point is 00:10:23 BetterHelp offers professional therapy with a licensed therapist carried out entirely online. I've been doing weekly therapy for over 30 years. Initially, I didn't have a choice. It was a condition of being allowed to stay in school, but pretty soon I realized that therapy is an extremely important component to overall health. In fact, I consider doing regular therapy
Starting point is 00:10:42 just as important as getting regular exercise, which of course I also do every week. There are essentially three things that great therapy provides. First of all, it provides a good rapport with somebody that you can trust and talk to about any and all issues. Second of all, it can provide support in the form of emotional support or directed guidance. And third, expert therapy can provide useful insights. With better help, they make it easy to find an expert therapist who you resonate with and can help you provide these benefits
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Starting point is 00:11:30 on this show with 90% off your first week of therapy. Again, that's betterhelp.com slash Huberman to get 90% off your first week. This would probably be a good time to talk about the whole concept that teeth can essentially build themselves and destroy themselves, independent of sugar intake and other factors. So if you would, could you just briefly walk us through, you know, this whole business of mineralization and de-mineralization of teeth?
Starting point is 00:12:03 Because I find this so interesting, and later I'll share a little bit, full disclosure. I have a very complicated oral health history. And had I known what you're about to tell us, I think I would have spared myself a ton of pain. Potentially. I'm sorry to hear that, but we'll impact that. You weren't my dentist, unfortunately.
Starting point is 00:12:25 No, I have stories to share too. We'll get to as well. I think many people do, and that's the problem. So I wasn't taught this in dental school, interestingly enough. So this is something I learned later out in practice, and it's the concept that your teeth can naturally remineralize if you have a small cavity. But let's start further back. So your teeth are constantly going through demineralization and remineralization.
Starting point is 00:12:54 And this is very natural. And anytime we put anything into our mouth besides arguably neutral water, and this has to do with pH, so anytime we eat, our mouth is the beginning of the digestive system. So we release amylase, which is an enzyme that helps break down our food, and in doing that the pH drops. This is how we start digestion. When that happens, we lose minerals in our teeth. The acid will leach out calcium, phosphorus, and minerals from our teeth. But the concern is we don't want it to stay in that acidic state for too long,
Starting point is 00:13:29 in that demineralized state for too long, because if we allow our body to do its thing, our saliva will naturally remineralize our teeth. This is all part of a healthy balance system. So our saliva is this golden elixir of our body and it contains immune cells and enzymes, but also the minerals that we should need if balanced to create that remineralization. So there's something called the Stefan curve. And essentially it's showing us how our mouth will become acidic and neutral and acidic and neutral throughout the day as we eat.
Starting point is 00:14:06 The problem is in modern society, we tend to be snacking and grazing and sipping all of the time. So we're not giving our mouths enough of a break, enough of an opportunity to remineralize. So many of us are staying in the state of constant acidity and demineralization. many of us are staying in the state of constant acidity and demineralization. But what's interesting is, so if you have a small cavity or lesion that hasn't yet truly cavitated, then a cavity means a hole. So if you look on an x-ray and I see a shadow on your tooth, it's called an incipient lesion. Those, if they're still in the enamel, those can, quote-unquote, heal or remineralize.
Starting point is 00:14:46 And this is where you would need to work with, let's say, a functional or biological dentist to understand how deep your cavity is. Once it becomes a hole, generally you do need some sort of treatment. But our body is meant for stability. It knows what to do, but how you eat, how frequently you're eating, and then we can get into this with how you're breathing and certainly the products you're using
Starting point is 00:15:10 and your hygiene practices all factor in as well. So my understanding is that the minerals that make up teeth are not the same materials that are put into a lot of common tooth care products. So without getting into a discussion right now about fluoride in water, we will get to that conversation a little bit later, but in order to frame that properly when we arrive there,
Starting point is 00:15:34 could you explain why it is that fluoride is in most toothpastes? When basically we don't have fluoride in our teeth at birth, but there are other minerals in our teeth that certain toothpastes have. So why would we give an artificial substance to our teeth? Maybe you could explain demineralization, remineralization in the context of fluoride and these other minerals.
Starting point is 00:16:02 So we have hydroxyapatite, which is essentially calcium and phosphorus in our teeth. Our enamel is about 90% hydroxyapatite. The dentin, which is the layer below the enamel through the enamel, is about 60, and our bone has hydroxyapatite too, about 60%. Our limb bones? Mm-hmm, all bone. 60% hydroxyapatite. Yes, which is calcium and phosphorus.
Starting point is 00:16:25 Our saliva will also have calcium and phosphorus floating around too. What fluoride does is it throws off the hydroxyl group in hydroxyapatite, so it changes it from hydroxyapatite to fluorapatite. It restructures it a bit. When it does this, the bonds generally are considered stronger and the dental crystalline structure is more densely packed, so it's known to be more acid resistant. And so we can get into the history of how they discovered this, but essentially fluoride was put into toothpaste in about the 1960s.
Starting point is 00:17:04 It became very popularized. So that is why many dentists love fluoride is that you're using it and it makes your teeth more acid resistant and also it has some antimicrobial effects too. The issue I have and we can unpack this more later is that it's not super selective. So it's not only selecting anaerobes or pathogenic bacteria, but it potentially could be damaging beneficial bacteria too. So that's why toothpaste has fluoride in it. It also will lower the critical pH. So the critical pH is the pH of which your enamel will start to demineralize or degrade.
Starting point is 00:17:43 And for enamel, it's 5.5, and then for dentin, it's closer to 6.5. So what fluoride does is it raises the pH resistance. I see, so for people that aren't familiar with pH as a measure of how alkaline or acidic a given environment or something is, and so what you're telling me is that fluoride makes teeth ultra strong. It's not a mineral that teeth normally see.
Starting point is 00:18:14 Like if a child never used fluoridated toothpaste or drank fluoridated water, they basically, unless they happen to drink from a stream with fluoride in it, their teeth would rely on hydroxyapatite to remineralize. But we put fluoride into toothpaste and into water, and that allows teeth to become even stronger and even more acid resistant. Yes. Some out there argue the enamel structure actually is weaker. This is very nuanced, but generally the dental community believes it's a stronger version of enamel.
Starting point is 00:18:47 Some will argue when you look under scanning electron microscopy, the crystalline structure can be more wave-like and potentially the bonds could break more easily. But generally, topical fluoride does work. However, it is no match for a poor diet. So all of this really comes back to what you're eating. So it will make you less at risk for cavities, but it's not a shoe in. It's not for sure going to prevent decay. What are the times in each 24 hour cycle when our teeth are repairing themselves?
Starting point is 00:19:19 So like in the middle of the night, provided somebody's asleep, they're not eating, they're not drinking unless they get up for a moment and have a sip of water or something. In between meals, they're not eating. I just sort of naturally intermittent fast. I generally eat my first bite of food somewhere around 11 a.m., sometimes a little earlier, but that's just habit. It sort of falls under this intermittent fasting kind of thing. So I and many people have stretches of time
Starting point is 00:19:45 of anywhere from three to 14 hours when we're not ingesting any food or caloric beverages. Is that when remineralization occurs? It's a tricky word. It's a tough one. Remineralization, we'll have to do it. Remineralization. Right. Oh, that's right, yeah, put the accent. Remineralization, thank you, that helps.
Starting point is 00:20:05 You said that before. Thank you. Is that when our teeth repair themselves? Yeah, this is great. This is important. So generally after you eat, as I mentioned, your mouth will become more acidic. After about 20 to 30 minutes, your saliva will naturally start to buffer. So it will start to rise
Starting point is 00:20:25 and raise the pH up. I like to see us eating more on a schedule. So generally every two hours or so is when we'll get full optimal remineralization. The issue is we are a society on the go and we're grabbing crackers and chips and granola bars and we're eating and nibbling and sipping on frappuccinos. so we never allow that remineralization to take its full effect. So yes, when you're not putting food or drink in theory in your mouth, your saliva, if it's optimized, and we should talk about that as well, will be remineralizing. But unfortunately, I do feel so many of us are just not in balance. You know, we're dehydrated, we're mineral deficient, we're calcium deficient, we're phosphorus deficient, and we're mouth breathing.
Starting point is 00:21:13 So the pH is changing just for mouth breathing can make the mouth more acidic. And so there's a lot of factors at play. But in theory, if I can make one suggestion to someone out there who might be struggling with cavities, I want to know not only what are you eating, but how frequently are you eating it? And this is a great reason why from a dental standpoint fasting, intermittent fasting, or time-restricted eating is a great way to combat dental decay. It's also better on gut health as well.
Starting point is 00:21:43 The migrating complex, the cleansability, just giving things a break and a rest is really important. I grew up hearing that sugar causes cavities. Does sugar cause cavities? And when we say sugar, of course, all the biologists and people with a nutrition background roll their eyes because sugar is a very broad statement, right? There are simple sugars, there's fructose, there's sucrose, there's glucose,
Starting point is 00:22:10 there's all sorts of variation within the simple and complex carbohydrates. But when I'm saying sugar, I'm thinking about foods that taste sweet or that contain sugar that's masked by other flavors, I just, for sake of simplicity. Like added sugar. Like added sugar.
Starting point is 00:22:27 I mean, now if you buy a cracker, typically if you look at the package, there's some sugar in there, which is ridiculous, but that's a whole other discussion. Yes. Or we could just even say starchy carbohydrates. Fermentable carbohydrates is what I like to say. Fermentable carbohydrates.
Starting point is 00:22:40 But that gets kind of nerdy. So not directly. It's really acid that causes cavities. So what sugar does, and I like everyone to think of flour like sugar. This is also very important because the bacteria in our mouth, they thrive, the pathogenic bacteria,
Starting point is 00:22:57 they thrive on sugar. But flour will act like sugar in the mouth. So they'll also thrive on flowers. So the crackers, the bread. Even a good sourdough bread. Well, the issue is... You have to give up sourdough bread. I like sourdough too.
Starting point is 00:23:11 The issue is more contact time. So things that are really sticky and dried, I would argue, so crackers or toast. Chips. Chips. I mean, think about if you take a handful of goldfish crackers. I haven't done that in a long time, but imagine that. It's all throughout your teeth, in between the teeth, down in the grooves. It's sticky.
Starting point is 00:23:35 It's just a smorgasbord for the bacteria. And so what do the bacteria do when they metabolize the sugar or the flour? They release acid. And so if that food substrate is stuck against the tooth for a long period of time, and these foods are also hyperpalatable, so we're meant to be just snacking and grazing, hitting the bliss point, you know, grab a handful, go do something, come back, grab another handful,
Starting point is 00:23:58 you're just constantly feeding that bacteria, so your mouth is staying constantly acidic. So it's truly the acid that causes cavities, but I would argue that sugar flour is kind of the catalyst that feeds the bacteria to create that imbalance. Is it fair to say, I know you prefer the term fermented carbohydrates, or trying to, for most people who don't think in terms of starches versus fiber, simple, although nowadays people are more versed
Starting point is 00:24:26 in that sort of thing, I think of carbohydrates or foods for that matter, that if you put them in your mouth and you just kind of kept them there for a little bit, that they would dissolve. Like a cracker. Like a chip, like rice, like a piece of pasta, as opposed to like a piece of broccoli, which would get soggy, but it's got a lot
Starting point is 00:24:44 of fibrous materials, so it doesn't dissolve in the mouth. And interestingly, broccoli or prebiotic fiber is what feeds the good bacteria. So I work mostly with children now, and we can talk about why that transition happened. I used to work with adults, but I teach them eat the rainbow. Feed the good guys, okay?
Starting point is 00:25:05 So we want to feed our healthy bacteria more than we want to feed the bad bacteria. And that's not to say you can't ever have fun and enjoy some fun foods, but it's all about balance. And so I think people don't realize the true root cause issue with dental disease is primarily diet. You know, we're so hyper-focused on fluoride and what's in your toothpaste and the mouthwash and all these products, but all of those things are really just masking the underlying issue, which is how are these bacteria behaving?
Starting point is 00:25:39 What types of bacteria and in what ratios do we have them in the mouth and how often are we feeding them? So I'm hearing this as a repeating theme that diet and lifestyle are going to be more important than drugs or products for keeping the mouth looking good and healthy. Yes. I mean, for example, I personally haven't used fluoride for many, many years, and neither have my children, just because I know there are other ways to prevent disease. And I have many of my patients that choose not to use fluoride or these products also.
Starting point is 00:26:15 I think so many people have been taught you have to have this product, fluoride, et cetera, to stay cavity and disease free. But if you eat a clean diet, focus on just some of the pillars of health, that will translate into the mouth as well. Perhaps it's worth mentioning just what some of the facets of a clean diet are through your lens of what you consider clean diet. Sure. So I'm not advocating for any one diet, and I do believe we're all different, so
Starting point is 00:26:45 what works for some people may not work for others. But generally, what I suggest is really high-quality protein sources, a wide array of vegetables, fruit. I would argue you should limit fruit potentially, especially if you're a high decay risk, just because there is sugar, fructose. But I don't want to villainize fruit. There's so many healthy benefits of polyphenols and everything in it. So nuts, seeds, olives, pickles, I love fermented foods for gut health and then oral microbiome
Starting point is 00:27:19 support too. So essentially a whole food diet, you know, things that come from the earth and more from farms than less from factories, less things out of bags, arguably ultra processed foods should be avoided as much as possible or minimized and then trying to stick to minimally processed or unprocessed foods. Is it fair to say that if one does that, either a child or an adult, that their oral microbiome will not only get healthier, but that their teeth will get whiter?
Starting point is 00:27:51 And the reason I keep bringing this up is I think a lot of people want white teeth, or at least not yellow teeth. Sure. Having been involved in the public-facing health education business for a little while now, I realized that nothing that is encouraged to be good for us that takes away from the way
Starting point is 00:28:10 that people want to look and feel about how they look gets much traction. So what I like about what you're telling us is that all the things of eating mostly unprocessed or minimally processed foods, those are gonna be good for our entire body. Great that it's great for our oral microbiome. Probably is good for our whole body
Starting point is 00:28:27 because of its effects on the microbiome, at least in part. But what makes teeth white? And will supporting the oral microbiome make our teeth whiter? And by the way, there are some folks out there whose teeth need to be less white, in my opinion. Agree, totally agree.
Starting point is 00:28:42 Now we're being somewhat facetious, but not really. But I think most people would like to have teeth that are, would be characterized as mostly white. Yeah. We want to look good. I mean, I appreciate and respect that. I do think we've moved a little away from reality with some of that. So I agree with you. I think there are teeth out there that could not be quite so bright, but you do you.
Starting point is 00:29:07 I think everyone should do what makes them happy. So what makes teeth white? So interestingly, if you look at a baby tooth next to an adult tooth, and I get this call all of the time from parents. So the child loses their first baby tooth, the adult tooth starts to come in, and adult teeth are quite a bit darker than baby teeth, which are very white and bright, and they're worried. What's wrong with my child's teeth? They're so yellow.
Starting point is 00:29:31 That's actually a very natural shade of enamel. And why is that? It all has to do with that crystalline structure and the mineralization. So baby teeth are less mineralized, and the crystalline structure is a little more haphazardly arranged. It's not quite as organized. So instead of like Lincoln logs lined up, it's more like pickup sticks to some degree. Why is that?
Starting point is 00:29:52 Baby teeth are meant to resorb, dissolve, and fall out. Okay, so this is why baby teeth are also much more susceptible to decay. So the whiteness is coming how the light reflects and refracts off the teeth, which is a lot of times why you'll hear if you use hydroxyapatite or even coconut oil, it's changing the surface modification. So it's changing the way light reflects and refracts off that tooth to make it seem whiter and brighter. Now, certainly with adult teeth, if you're using bleaching agents, you know, hydrogen peroxide or carbon dioxide, some of the stronger bleachings,
Starting point is 00:30:29 that's actually penetrating into the tooth and changing the structure, pulling out stain. Do people do that? They gargle with hydrogen peroxide? Well they do bleaching trays essentially. I don't, well people will rinse with hydrogen peroxide, yes, and it will make your teeth brighter and whiter, but I'm telling you, it's gonna do a number on your oral microbiome. So I suggest it in a very limited fashion. The only time I ever had a bad canker sore
Starting point is 00:30:55 was because I gargled with 50% water, 50% hydrogen peroxide, because an acupuncturist recommended it. He looked at my tongue and then he said, you should do that, you know, and then I did that. And then, you know, four or five days later, I had this like nickel sized canker sore on the roof of my mouth.
Starting point is 00:31:16 And I was like, ugh. And I will say, and I have no product affiliation whatsoever but to any specific products, but by switching to hydroxy appetite containing toothpaste, my teeth, they definitely have gotten whiter. I drink a lot of yerba mate and coffee and I brush, but it was sort of a progressive issue of my teeth dimming. So that's been great.
Starting point is 00:31:41 I also used to get cavities fairly often when I was a kid. I'll talk about that a little bit later. But since switching to hydroxyapatite toothpaste, I've had like stellar dental reviews, assuming my dentist is looking carefully. I believe he is, but we'll see. And to me, it just makes so much more sense. Like give teeth the mineral that they normally use
Starting point is 00:32:01 to re-mineralize. It just makes sense. Like it- It's biomimetic. It depends on how you look at life, I think. I prefer biomimetic materials personally. Again, it's a personal choice, but I agree with you. My patients who have switched to hydroxyapatite,
Starting point is 00:32:19 and I'd like to point out not all hydroxyapatite toothpastes are the same. It depends on sourcing and the other ingredients that are in there. But generally speaking, their teeth look healthier, stronger, whiter and brighter. They just look more nourished, more hydrated. Their microbiomes look more balanced too. You're talking about kids and the fact that sometimes if their teeth are a little bit yellow that's normal.
Starting point is 00:32:43 One thing that I've been really struck by as the discussion around longevity seems more and more prominent these days is occasionally I'll run into somebody who's in their 70s or 80s, even 90s. And it's very rare to encounter somebody in their 80s or 90s whose teeth are not like the color of this tea.
Starting point is 00:33:03 And for those that are listening, it's like a very dark brown. I've never seen somebody, unless they're doing something highly artificial with bleaching, I've never seen somebody 75 or older whose teeth aren't basically yellow to brown. And when you look at people when they're very close to death, their teeth often look very opaque. What is that? Is that a blood flow issue?
Starting point is 00:33:28 Is it, what's going on there? Yeah, it can be a zero stoma or dry mouth. So we definitely lose salivary capabilities as we age, very likely more mouth breathing. So mouth breathers will tend to have darker teeth because the teeth desiccate, they dry out and over time you will experience mineral loss. Decades and decades of coffee, tea, wine will do it too. Well, I don't drink the wine, but I've been drinking coffee, tea since I was a little kid.
Starting point is 00:33:56 I've been drinking latte since I was like five. It's good. Yeah, it's delicious. Yeah, gotta live life. But yeah, and so they're losing minerals too, over time. Your teeth take a beating. I mean, we're living to be a hundred now. That's a long time to maintain
Starting point is 00:34:12 this non shedding surface in our body. So, and then it depends on the generation too, but some generations, especially as you mentioned, 70s, 80s, I'd wonder about tetracycline exposures when there's certain antibiotics that we don't use anymore that can, were known to darken the teeth, which is why they pulled them from common prescription. That raises a question I'd never thought about before.
Starting point is 00:34:36 So if one takes a course of antibiotics, typically the advice is to ingest low sugar kombucha, to have some Bulgarian or Greek yogurt, like repopulate the gut with healthy, with the substrates for healthy microbiota. We now know, because you've told us that the mouth is the gut, which makes perfect sense. We are but a series of tubes.
Starting point is 00:34:58 That's why I always teach in my developmental neurobiology class, but it's true. It's true. In embryology, you learn that we're basically born of a bunch of tubes that are gonna do their thing in development, but the digestive tract obviously starts with the mouth. So is it the case therefore that we should be repopulating
Starting point is 00:35:20 the oral microbiome if we take a course of antibiotics? Yes, yes, very commonly patients, parents will report, gosh, my child just finished this course of antibiotics and now their teeth are stained or their gums are inflamed or they just seem off. And it usually is because they've wiped out a lot of the healthy bacteria too. You know, it's all connected.
Starting point is 00:35:40 So I do suggest my patients, if I have to write antibiotics, which I try to avoid, but sometimes we have to, that they do take a high quality probiotic and increase their probiotic-rich fermented foods as well. So a high quality probiotic pill. Generally, yeah. Because it's hard to get in enough, especially in kids, I would argue. Kids aren't usually eating a lot of sauerkraut and kimchi and natto. But you know, you could do kefir, yogurt, as you mentioned, low sugar, kombucha, et cetera.
Starting point is 00:36:09 But usually a high quality gut probiotic will have some benefit to the oral microbiome, but they also do have oral probiotics to focus on the bacteria of the mouth. What about mouth washes? Yeah. I've never liked them. They feel, they burn for one. And then I learned some years ago, and this is just kind of fun to cue to, years ago,
Starting point is 00:36:34 it must've been like eight, 10 years ago, I heard, I think on the Tim Ferriss podcast, somebody said, oh, you know, mouth washes will nuke certain chemicals that are essential for cardiovascular function. And so don't use them, don't use mouth strips, don't use any of that stuff.
Starting point is 00:36:53 And at that time that was considered like clear, quote unquote, pseudoscience. Nobody would like alternatives, science outrageous. Now we know this is actually true. And this always delights me and scares me at the same time that many of the things that right now people go, oh, that's pseudoscience. Creatine seems to be a big thing right now.
Starting point is 00:37:15 10 years ago it was only the gym rats that we're talking about now. Everyone's like creatine, creatine. Everybody needs it. So what's the story on mouth washes and mouth strips and mints and things of that sort, that again, people just wanna have fresh breath or at least they don't wanna be the person
Starting point is 00:37:29 with the bad breath. Sure. Yeah. So Listerine and those stronger rinses in particular, they generally contain alcohol, astringents, really strong anti-microbials. You know, it says kills 99.9% of germs. Well, I think we've learned we're over-disinfecting, you know, this is why asthma is up,
Starting point is 00:37:50 eczema, allergies are up in our children. We now are saying get into the dirt, get, you know, get exposed to microbes and things. So we're carpet bombing the mouth. What we've learned through the data, and you're right, there are studies to show that carpet bombing the mouth. What we've learned through the data, and you're right, there are studies to show that chronic habitual use of these mouthwashes, including prescription-strength mouthwash like chlorhexidine is a common one, it can damage the nitrate-reducing bacteria. So we have bacteria in the dorsum of our tongue specifically, that is essentially your tongue, that reduces nitrate to nitrite, which is
Starting point is 00:38:25 a precursor to nitric oxide. Nitric oxide is a molecule that is really important for cardiovascular health and vasodilation and immune health. So if we're indiscriminately carpet bombing the mouth with these really strong astringents and rinses, we can be affecting our cardiovascular health and there are studies to show it can increase blood pressure and potentially cause cardiovascular issues. So when I hear someone say, but my breath is so bad, you know, I have to use this multiple times a day, I immediately think, well gosh, why is
Starting point is 00:39:00 your breath so bad? It's normal to have bad breath after you eat a garlic hummus or have a cup of coffee. But if it's chronic halitosis or bad breath, I'm curious, do you have periodontal disease, which is a chronic inflammatory issue in the mouth, which can have a slew of downstream effects, which we should discuss in a bit? Or do you have an infection? It could be a sinus infection, post-nasal drip. Do you have tonsil stones or tonsillar infection? Like what else is going on in your mouth where you feel you need this multiple times a day to even feel like you can present yourself in public? Really strong essential oils and mints, again, I would be cautious with that. Every once in a while throwing in a piece of gum
Starting point is 00:39:47 or a mint, of course. It's really the habitual use of these things that can be damaging. I'd like to take a quick break and thank our sponsor, AG1. AG1 is an all-in-one vitamin mineral probiotic drink with adaptogens. I've been taking AG1 daily since 2012. So I'm delighted that they're sponsoring this podcast.
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Starting point is 00:42:14 Again, that's Juve spelled J-O-O-V-V.com slash Huberman to get up to $400 off. Okay, so those are some don'ts. What are some things that we can do to improve the chemistry of our saliva and our mouth? And just to, in full disclosure here, won't be the disclosure most people are anticipating. What I'm trying to get at here is all the chemical aspects,
Starting point is 00:42:38 the chemistry of the mouth. Because when I think about biology, just because of my training, I think you've got chemical forces and you have mechanical forces. Like there's stuff that literally like moves or you could, you know, chip a tooth or things that you shouldn't do to protect your teeth. And then there's how to create the right
Starting point is 00:42:54 chemistry environment. So that's really what we're talking about here. And I'm trying to figure out, you know, how could I have the best possible saliva? Yeah. I wanna be the person with the best possible saliva. Good spit. Yeah.
Starting point is 00:43:08 Good spit. Don't underestimate your spit. It's true. It's the golden elixir of your body. So if I were to put spit into like under the microscope or then also take some of my spit and put it in mass spec and separate out all the goodies that are in there, just give us a sense of the kinds of goodies
Starting point is 00:43:25 that are in spit. What's in there? Because it just looks like a bunch of clear liquid to people, but blood looks like just a bunch of red liquid and there's a lot of stuff in there. There's so much in it. It's so important. So it has bacteria, viruses, fungi, like all kinds, protozoa, hopefully in the right ratios.
Starting point is 00:43:43 So we want beneficial bacteria. We all have about 5% pathological bacteria. However, at that ratio, it may, those may not be pathological. Like they are, they're symbiotic at that point. We are still unpacking and learning more about the oral microbiome. But essentially you'll have bacteria. Um. There's hormones, there's free cortisol. There's hormones.
Starting point is 00:44:04 Cortisol is in our spit cortisol. There's hormones. Cortisol's in our spit, folks. Yes, absolutely. There are enzymes for aid in digestion, there are immune cells, and there are minerals floating around too. So think about how important saliva is to chew. If you have dry mouth or you're sick, you can't chew and swallow your food, and this is why a lot of elderly people have a very hard time eating certain foods or if
Starting point is 00:44:28 you've undergone cancer therapies and things. Once you get xerostomia, dry mouth, your teeth can degrade so quickly. So your saliva is so important. And so how do we keep it healthy? Hydration. So many of us are dehydrated. I would argue we aren't getting enough minerals either, so you know, I suggest to some kids, I can tell in a child's mouth
Starting point is 00:44:52 if they're hydrated or not by the way their saliva looks. If it looks more thick and ropey and mucousy, they're dehydrated. If it looks like water, it's healthy. This is without any tests. So put a pinch of salt in your water or some electrolytes. That can really help with bioavailability and absorption. How you're breathing is incredibly important too for your salivary health. So if you're mouth breathing, you will have less saliva. You know, your mouth's gonna dry out, the pH will drop
Starting point is 00:45:22 and you're gonna be in trouble. You know, dry mouth leads to cavities, dry mouth leads to gum disease. So and then the foods we eat, of course, too, we want to have a mineral rich diet. So many of us are mineral deficient, we're magnesium deficient, we're fat soluble vitamin deficient, particularly vitamin D3, K2. So I think it is good, I like the idea of test don't guess, you know, if you have the capability to work with a doctor to see where you are with some of these things to know if you need to supplement or not or how you can change your diet.
Starting point is 00:45:56 Sorry to interrupt, but would I test my saliva specifically? Is there a good saliva test out there? That would be a different test. This would be more of a blood test. Like a standard blood test for- A standard blood test, but there is salivary analysis, and we should discuss the importance of testing your oral microbiome.
Starting point is 00:46:13 I think just like so many of us test our gut microbiomes now, GI mapping, stool tests, to understand what's happening in the gut, there's salivary analysis now, and this is what a lot of functional dentists are working toward. I do salivary analysis and biomarker analysis in my practice. We can tell a lot through a patient's saliva in what ratio and types of bacteria are there, as well as fungus and viruses and things as well. So if you have the capability, if you
Starting point is 00:46:43 really want to optimize your health, I suggest testing your oral microbiome because there are certain keystone pathogens that you may have that you're unaware of that can lead to many downstream issues. And we can jump into this now, but the oral systemic connection is really blowing up now in how oral bacteria, specifically pathogens, can contribute to Alzheimer's and dementia and fertility issues, pregnancy issues, cardiovascular issues, autoimmune disease, rheumatoid arthritis, diabetes, obesity, mood disorders, cancers. It goes on and on, all coming back to the bacteria in our mouth. Amazing.
Starting point is 00:47:23 I really want to not just double click, but really dive into that, no pun intended. I do want to just ask because a subset of listeners will be interested in how they could get their saliva tested. Yes. I've never had my saliva tested. I will say that based on your teachings online, I've made an effort to drink more water
Starting point is 00:47:43 in addition to massive amounts of yerba mate and small amounts of coffee. I've made an effort to, well, I switched to a hydroxyapatite containing toothpaste, which has been terrific for all sorts of reasons. I've really emphasized nasal breathing. That's something I was into before through the sports performance world, because my friend Brian McKenzie,
Starting point is 00:48:07 who's a human performance expert, was really big on this a while ago. And the healthiest my breathing and cardiovascular function ever was for me was when something I don't suggest people do, unless it's their profession. I was boxing for about a five-year span, and I had a fitted mouthpiece, and I would do my running, my road work
Starting point is 00:48:26 with my mouthpiece and breathing through my nose. And that taught me to, like, really how to breathe correctly through my nose, and it translated to switching to nasal breathing when I slept. I didn't sleep with a mouth guard in. But I think that breathing through the nose is just so important for the reasons
Starting point is 00:48:44 you're describing, James Nestor's described, and I will share this little factoid, and then I'll shut up and nasal breathe. A friend of mine who is a physician at UCSF, he told me that the methamphetamine addicts that come in have terrible teeth. Everyone knows this, meth addicts have terrible teeth.
Starting point is 00:49:06 But do you know why it is? He works with the school of dentistry. It's because they're mouth breathing. I've worked with that population before. Meth doesn't actually deteriorate the teeth. It's the fact that they're mouth breathers. And so I find this fascinating. And then of course the book Jaws,
Starting point is 00:49:21 which was published by Paul Erlich and Sandra Kahn, my amazing colleagues at Stanford years ago. And by the way, when they published that book, people said, oh, this is pseudoscience, this is crazy. You're saying nasal breathing, epidemic of fear mongering. Well, we now know this is a real thing. It's an epidemic.
Starting point is 00:49:37 So how do you encourage kids and adults to switch from mouth breathing to nasal breathing? Yes, this is a big part of my practice. So we need to understand the why, just like anything. Why are you a mouth breather? So humans are obligate nasal breathers where we are meant to be breathing through our nose. Unfortunately, so many of us are mouth breathers.
Starting point is 00:50:02 They estimate up to 50% of the population now breathes through their mouth. I personally think that's an underestimate with what I'm seeing in my practice. So why is this? So the theory is that ancestrally, we used to chew and masticate up to four hours a day. This act of chewing, it pushes, forces out, it was actually what grows the face, the lateralization of the tongue, the tongue elevating, it would grow the jaws wide, the sinuses wide, including breastfeeding. We now flash forward 10, 12,000 years.
Starting point is 00:50:42 So we had the agricultural revolution, we went from hunter-gatherer society to agrarian. Then the industrial revolution, we started milling and processing everything. Everything's soft and mushy now. We used to chew four hours a day. We now chew four minutes a day. So there's very little, there's atrophy essentially. We slurp our food.
Starting point is 00:51:02 We slurp our food. It's like that movie. What was that futuristic movie with the little robot? Wally? I hated that movie. Oh, I cried during that movie. I hated that movie. I was so worried that it was true and here we are.
Starting point is 00:51:13 Yeah, they were slurping their food, lying on recliners. Here we are. They've outsourced pretty much everything. Yes. Yes. So this is many generations of this happening. We're essentially shrinking. James Nestor phrases that were dis-evolving.
Starting point is 00:51:29 Okay, so faces are shrinking, jaws are shrinking. This is why we see so much crowding in teeth. If you go to the Natural History Museum in New York, Washington, DC, look at the ancestral skulls. The teeth are pristine, there's no decay, and all 32 teeth, including the wisdom teeth, fit perfectly into the dental arches. So that was not that long ago in human, you know, our trajectory.
Starting point is 00:51:55 So what has happened? It's our food, it's how we're chewing, it's how we're breathing. And so if this structure shrinks, the nasal volume shrinks, the sinuses shrink, the airway shrinks, our tongue has no room in our mouth anymore. So it either sticks out, tongue thrusts, or it falls back, you know, and it's obstructing us. So there's so much sleep-disordered breathing, dysregulated breathing, and sleep apnea now
Starting point is 00:52:21 that's not getting diagnosed. So if we look at children early and they come into me and I can see it as they walk in, they generally will have forward head posture because they're trying to open their airway. Forward head posture, they have dark circles that's called venous pooling. That's a sign of inflammation secondary to mouth breathing. You can see more of the whites of their eyes, so it has to do with their visual plane. So forward head posture, the droopy eyes from inflammation, you see more of the sclera, the white of the eye.
Starting point is 00:52:55 They just look congested and sick. They just, and their mouths open. And those kids have major airway issues and we need to understand why. So it is generally either a hard tissue issue or a soft tissue issue. So what would the hard tissue issues be? That would be the size and shape of the jaws, the size and shape of the palate, the position of the jaws, is your jaw set back? Is it forward like a bulldog?
Starting point is 00:53:25 And do you have a deviated septum? They asked me, 75% of humans can have some sort of deviated septum and people think that's ridiculous. It's not just from getting in a fight and getting your nose broken. So think of it this way. If your palate is narrow and I smoosh your face like this, the septum has to go somewhere and so it will can't. Okay, so that's what creates the deviated septum. And so if we expand a face,
Starting point is 00:53:53 and this is what early functional orthodontists and this is what I'm doing in my practice or doing in these younger kids, you put in a little retainer that can help expand the face and the septum straightens and now we can breathe better. So that's hard tissue. Soft tissues could be enlarged adenoids, enlarged tonsils, oral motor dysfunction, low tongue tone,
Starting point is 00:54:15 low tongue positioning too. How much plasticity is there of the sinuses? So let's say somebody has a partially or severely deviated septum and they could get surgery. And I want to talk about some of the different surgeries. There's a balloon expansion thing that online, it looks really cool. I like a lot and try this.
Starting point is 00:54:36 I really want this to happen to myself. Yeah, they put the balloon up there, they inflate the balloon. And it's guided. They do one that's guided. Yeah, they numb it and then they take it out and the, you know, this kind of thing. Well, is actually the appropriate way to do it,
Starting point is 00:54:49 both in and out through the nose. But if somebody makes the effort to nasal breathe, so maybe they mouth tape at night, or I'm a big fan of shifting from any mouth breathing to nasal breathing by insisting that I nasal breathe while I do any cardio, unless I'm pushing really hard, and then I need to bring mouth breathing into it. But I've noticed just because I can measure snoring
Starting point is 00:55:12 through, I sleep on an eight sleep, I can measure snoring that way, but even if you don't do that, there are other ways you can measure snoring with an app, or someone can tell you you're snoring. So this isn't about a product per se. But if I force myself to nasal breathe during cardio workouts, especially kind of zone two,
Starting point is 00:55:29 zone three stuff, translates to less mouth breathing and snoring and sleep. So the question is, do the sinuses actually dilate or if you have a deviated septum, do you need it surgically or somehow otherwise repaired? It depends on your age. So most facial development is done around the age of 10. So the issue I would say with traditional orthodontics, which is when you wait for all
Starting point is 00:55:52 the baby teeth to fall out and then you put braces on, you can't control the modeling of the face, the mid-face, the jaws, which is why we now are starting with functional therapies as young as three or four years old with retainers. So in the middle of our palate is a suture filled with cartilage. And so with kids, it's really easy to manipulate and change facial development. If you make the jaws wider, not only is it improving airway, but the teeth will come in straight. Now they have room.
Starting point is 00:56:24 The reason they come in crooked is there's not enough room for them to come in. It's important to note the floor of the mouth, the roof, sorry, the roof of the mouth is the floor of the nose. So if you expand the palate, the sinuses will get wider, the septum's going to upright, everything's connected. Now as an adult, it's really hard to manipulate bone structure just through posturing and habit. There are myofunctional therapists,
Starting point is 00:56:53 which they're the best and they're really important in this conversation. Think of them like physical therapists for breathing, teaching you to keep your lips closed, your tongue up, all of this musculature is really important, toning it. If you don't use it, you lose it. So if you're a mouth breather, your tongue will lay low, your tongue's a muscle, it will get weak, it will get flaccid. So we want to strengthen these muscles to help with lip seal and nasal breathing. But as an adult, if you do have a skeletal
Starting point is 00:57:24 discrepancy, usually you need some sort of intervention. You're not going to just be changing it through lip taping or how you're training or myofunctional therapy. And there are more conservative ways now besides true jaw surgery. There's an appliance called the homeoblock, which I know is what James Nestor used.
Starting point is 00:57:44 You can read about it in his book that will actually start to change facial structure. There's less invasive treatments. There's an MSC appliance. It's a maxillary skeletal expansion device. It does put these little mini screws in your palate, but it will pop the suture and adults in this is you really would have to want this because you're struggling so much. And people who aren't breathing well, they're struggling.
Starting point is 00:58:10 I think it's the most important thing for health is how you're breathing and how you're sleeping. And with children, if they're not breathing appropriately and they're waking up a lot, which is why it would be interesting to get some sort of product on you. I'm just curious, do you get into deep sleep? Do you get into REM sleep? I do.
Starting point is 00:58:29 And for great. Yeah, I'm measuring deep sleep and REM sleep through the 8 Sleeper Whoop or both. My deep sleep is great, provided I get to sleep by about 10, 10, 30, because that's when you capture the deep, when I capture the deep sleep window. If I go to sleep around 11 or midnight, I lose out when you capture the deep, when I capture the deep sleep window. If I go to sleep around 11 or midnight, I lose out on some deep sleep, even if I sleep longer. And my REM sleep's really solid these days.
Starting point is 00:58:52 Yeah, I'm struck by how convincing the data are about nasal breathing improving brain function. There were a couple of studies that showed that if people either mouth breathe or nasal breathe in a laboratory study, the nasal breathers have better memory recall. But those were of odors. So everyone said, well, okay, of course it's of odors and you're breathing through your nose and so you can remember those odors.
Starting point is 00:59:16 So they've now run these studies on with other types of memory and brain function. And it's just very clear that you oxygenate your brain better and you think better, your cognition is better, your memory is better for everything, not just odors. So you get 20% more oxygen when you nasal breathe, and this is really important for children in these formative years of brain development. And this is why we're seeing studies showing that children who mouth breathe have sleep disorder breathing, they have behavioral issues, and many are getting diagnosed with ADHD and arguably potentially put on medications when really if we'd screened them for airway issues, potentially we could have avoided some of this.
Starting point is 00:59:57 And it also has to do with not getting into deep sleep, the glymphatic system's not kicking in, hormone function's not kicking in. So a lot of these children, growth hormone is impaired, antidiuretic hormone is impaired if they're not getting into deep restorative sleep. So that's why we see bedwetting. Some signs to look for in your partner or your children is tossing and turning, clenching, grinding, snoring or noisy breathing, sleeping in really odd positions like craning the neck because they're trying to open their airway,
Starting point is 01:00:30 spinning around the bed, you know, the child's legs are in and the body's like out of the bed, the bedsheets are everywhere and then certainly waking up unrested and then noticing behavioral issues too. Well, all you have to do to convince the male half of the audience to focus more on nasal breathing is to tell them, and to not use mouthwashes, is to tell them that being a
Starting point is 01:00:51 mouth breather will give them sexual dysfunction or will predispose them to sexual dysfunction and they'll start working on their nasal breathing. Because of nitric oxide. Because of nitric oxide. So the paranasal sinuses is what will help produce nitric oxide too. So if you're breathing through your mouth, not your nose, you're not getting enough nitric oxide,
Starting point is 01:01:12 which is very important in sexual health. But also we know men who have gum disease are 2.85 times more likely to have erectile dysfunction as well. Wow. So no bleeding gums. We do not want inflamed bleeding gums. Flossing is something we haven't touched upon yet, but it's incredibly important not only
Starting point is 01:01:32 for cavity prevention, but gum health. Pink in the sink, any amount of bleeding is a sign of inflammation and it doesn't just stay in the body. It can impact the entire system. So please take your gum health seriously if for nothing else than for your sexual health. Great message. So to shift over to nasal breathing,
Starting point is 01:01:53 if somebody's really struggling with this, are you a fan of mouth taping? Yeah. You want to make sure you can do so safely. So with kids, I always suggest they get screened by an airway focused dentist or potentially an otolaryngologist or an ENT. For adults, there is a task that you can do. It's the three-minute task. Can you breathe
Starting point is 01:02:16 through your nose without panicking or feeling sympathetically challenged for three minutes? So you can either put water in your mouth, put a piece of paper, tape your lips, and literally time yourself. And if you can breathe through your nose successfully, then you in theory can safely lip tape. There are different tapes that you can do so you that there are open in the middle so you can still off gas or you'd feel less, it feels less invasive. And what I suggest if people are interested in it is just start five minutes while you're chopping vegetables for dinner
Starting point is 01:02:51 and then move up to 30 minutes while you're watching a show and then watch a whole movie for two hours. And then if you've been able to tape that long, you can do so at night as well. I will tell you, it is one of the top things that I have done to improve my health. And I do see it with my wearables and my sleep data. Recently, I had the privilege of giving a talk
Starting point is 01:03:13 at Stanford with Renee Fleming. It's like one of the world's greatest opera singers alive today. And I said, what are some things that you do for your breathing? Because I ended up talking a lot for the podcast and she gave me some lung and diaphragm strengthening exercises. But then the one that she suggested for emphasizing nasal breathing, because there's a lot of
Starting point is 01:03:34 nasal breathing that's done quickly and subtly in order to maintain air pressure in the lungs and for her craft, which I know very little about, but is instead of like doing weight training for the neck, as kind of a fun about, but is instead of like doing weight training for the neck, as kind of a fun one, it doesn't make the neck big. So people who don't want a larger neck will appreciate that. But to exercise the internal muscles of the neck, and the way you do this is something called kiss the sky. The boxers will actually know this, the old school boxers,
Starting point is 01:03:59 it looks ridiculous, but I'll do it, because I look ridiculous on this podcast all the time intentionally. So you look up at the sky and you pucker like you were a puffer fish for 15 seconds per side. Interesting. And she said it builds the strength and the neural control over the internal muscles of the neck.
Starting point is 01:04:16 So again, no widening or thickening of the neck, but on the inside, and it makes it much easier to take deep breaths through your nose. It probably increases the amount of resistance so that you can fill your lungs more easily. So I've been doing a little bit of like kiss the sky and it looks completely ridiculous. It's kind of a yoga move too.
Starting point is 01:04:31 Yeah, and you just like really like lip smack as if you were gonna kiss the sky from side to side, 15 seconds per side, a couple times per day, or just whenever you remember it. And I mean, her voice is amazing, like her speaking voice and her posture and everything. So I borrowed that one from her. You can do a lot to improve your airway health
Starting point is 01:04:50 through breathing rehabilitation. So I think that is a big part that's missing in these conversations with airway health. We talk about, well, you need to see the airway trained dentist, you need to see the myofunctional therapist, the orthodontist, the ENT. That's a lot. Just the scheduling of that alone makes me wanna take a nap.
Starting point is 01:05:08 But it is, it's a lot to unpack airway issues. If parents are out there, there's two books, three, I'd recommend if you're very interested in this since it impacts so many people. Certainly, Breath by James Nester, Jaws, as you mentioned, by Sondra Khan, and Sleep Wrecked Kids by Sharon Moore.
Starting point is 01:05:27 If you're a parent. What's the title again? Sleep Wrecked Kids. Sleep Wrecked, W-R-E-C-K. Yes, by Sharon Moore. So it will just help you screen and understand why we're worried about these things more. But yeah, we can't overemphasize airway health, especially in our children, you know,
Starting point is 01:05:47 and catching it early and intervening early is really important. Great. In trying to maintain airway health and healthy saliva, and now I'm obsessed with saliva, it's like, cool, it's got all this stuff in it. I was thinking it was just like, we know blood has all these goodies in it, we test blood.
Starting point is 01:06:04 We know skin microbiome, we know that, women go to an OBGYN, they get pap smears, they get, I mean, we know if you ever raised a kid or changed diapers, you can tell a lot about somebody's health by the fluids they emit and that they have within them. I'd like to play saliva on the list of critical things to pay attention to, but chewing gum, is this good for our breathing and for our saliva or not?
Starting point is 01:06:33 Not a big gum chewer, but is it good, bad, neutral? Yeah, I think it's time and place can be very beneficial. So where I like it is if, because I will say, hey, parents, you really need to avoid crackers and chips and granola bars. And they say, what do I feed my kid? You know? So if we've missed the window of how to introduce food to children or they just favor those type of foods, what's a good strategy if you're out on the go to minimize decay risk and increase salivary health? Choose some gum, particularly xylitol gum,
Starting point is 01:07:10 because xylitol will inhibit bacterial proliferation. It will reduce strep mutans, which is the bacteria that causes cavities. Big fan of xylitol. So offering a piece of xylitol gum after an exposure to some of these snack foods, these fermentable carbohydrates is great. It will loosen the food, it will increase salivary health. Some people like it to strengthen, you know, mastic gum. I always get asked about that. You can overdo it. You know, I worry about tempomandibular dysfunction. I had a bad experience with mastic gum. I was buying it. I love the kind of the primordial aspect of it.
Starting point is 01:07:50 It's like a tree sap that you chew on. It comes in this beautiful paper package and, you know, no plastics or anything. You get it going in there and you feel like you're really, like, working it the same way my bulldog, Costello, would, like, work. He used to, like, teeth on, like, bricks. And, like, he used to,
Starting point is 01:08:05 and you'd feel great, and then all of a sudden, you'd go, and your jaw would kind of stick in, and then later you're like, whoa, my jaw really hurts. Or you feel something pop up in your joint. You feel something pop, and yeah, it'll give you that. These days, the young influencers are so obsessed by this, it'll give you a little bit of a golf ball, hypertrophy of your jaw.
Starting point is 01:08:24 That's not why I was doing it, but boy, does it make your jaw feel sore. Yeah. Yeah. I'm not a big fan. I like to just explain it. Think of a baseball pitcher. I mean, how many of them go on the disabled list because they're overusing their shoulder.
Starting point is 01:08:39 It's a similar joint, you know, rotation. If you're chew, we're only meant to chew really for sustenance. That's how we were evolved. So if you're chewing gum all day, it's very likely wearing down the cartilage in your joints. So I'm not a huge fan of it. I just personally don't love gum chewing, but I think time and place too. So especially from a cavity standpoint or hydration, you know, increasing salivary flow.
Starting point is 01:09:06 But just, I would just chew it for a couple of minutes, throw it out. You don't need to be chewing it for an extended period of time. But chewing food is good. Yes. Yes, thank you. So the issue, as we mentioned, is, you know,
Starting point is 01:09:19 we are slurping and smushing our food. Oh, gross. I don't, to me, almond butter has never existed in nature. The idea that you would take, I mean, almonds are so delicious, right? But that you would grind them up and put them into a paste. To me, the texture is so aversive. Well, you do that in your mouth.
Starting point is 01:09:39 You're supposed to do that through chewing. Just the fact of, like, your peanut butter. To me, these things make no sense whatsoever. It's go-gurts and apple sauces and fruit snacks. Baby food. Baby food, exactly. It's for animals and people without teeth. Exactly, so I'm not advocating in one camp or the other.
Starting point is 01:09:55 There can be a mix, but you know, there's blended food that's offered, or you can do more of a baby led weaning, which is eating more real foods. Obviously, please be smart about this. Don't get choking hazards to your children. There's a lot of information out there that you can look on how to safely prepare food
Starting point is 01:10:13 for your child, but chewing is incredibly important for facial development. Well, I was thinking for adults. I was kind of making fun of the fact that adults are eating like kids. Like they're like slurping their food and they're like. Chicken nuggets and french fries and yeah, we need to chew. When really asked what's gone on with the airway?
Starting point is 01:10:31 Why does everyone, why are faces shrinking? It's chewing, we've lost chewing. And then arguably breastfeeding too, we've moved away from exclusively breastfeeding too. What are the numbers on that? I don't know the numbers on that. How many people, I don't know either. I don't know.
Starting point is 01:10:46 But it's certainly down. I think it's making a resurgence. And a lot of people though are doing a blend. We do what we need to do. It means a lot of women are working. So it's important to know if you're not able to breastfeed or it doesn't resonate with you or you are working and having a pump, that there are fixes, okay? So this isn't dire, but just working with someone
Starting point is 01:11:09 to catch these issues early. And also, unfortunately, even if we're doing all the things correctly, introducing hard foods, our child's chewing and their nasal breathing and we're breastfeeding, it's hard to combat generations and generations of dis-evolution, essentially. So a lot of humans are needing intervention now. I'd like to take a quick break and acknowledge one of our sponsors, Function.
Starting point is 01:11:32 Last year, I became a Function member after searching for the most comprehensive approach to lab testing. Function provides over 100 advanced lab tests that give you a key snapshot of your entire bodily health. This snapshot offers you with insights on your heart health, hormone health, immune functioning, nutrient levels, and much more. They've also recently added tests for toxins,
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Starting point is 01:12:42 in a blood test. The problem is blood testing has always been very expensive and complicated. In contrast, I've been super impressed by Function's simplicity and at the level of cost. It is very affordable. As a consequence, I decided to join their scientific advisory board and I'm thrilled that they're sponsoring the podcast. If you'd like to try Function, you can go to functionhealth.com slash Huberman. Function currently has a wait list of over 250,000 people, but they're offering early access to Huberman podcast listeners.
Starting point is 01:13:10 Again, that's functionhealth.com slash Huberman to get early access to Function. Earlier you mentioned the many different systems and diseases of the body that the oral microbiome has been directly linked to. I would say in science and medicine, there are direct effects like this mediates that, and then there are indirect effects.
Starting point is 01:13:33 Like if a fire alarm goes off in the middle of the night, your sleep isn't good, but fire alarms don't regulate sleep. They just can mediate, they can modulate your sleep. But my understanding, and I'm not deep in this literature, but my understanding is that we now have fairly conclusive evidence that certain bacteria from the mouth make its way to the brain or heart or other tissues
Starting point is 01:13:58 and directly increase either the occurrence or the susceptibility of dementia, cardiovascular disease. That this isn't just, you know, oh, you broke your ankle, so you move less, you move less, your heart gets less healthy, your heart gets less healthy, your brain gets less healthy. This is the kind of point I'm trying to make. But that the bacteria in our mouth, bad bacteria,
Starting point is 01:14:20 can cause real problems for the brain and heart. Yes, and many other systems too. So much research. So they're finding 57 diseases are linked back to oral dysbiosis or oral pathogens, which is quite a lot. And different species can affect different parts of the body. So what does this all come down to?
Starting point is 01:14:42 It comes down to gum disease. So it's important to note about 80% of the global population suffers from some sort of gum disease. That's huge, you know. And about 10% of the population will have severe periodontal disease, which is chronic bone loss, tissue loss, and this is where we get tooth loss too. So gum, it's sort of a continuum, but these all have one thing in common, it's the type of bacterial species that live in our mouths and when they get out of balance.
Starting point is 01:15:13 So there's something called the red complex. These are the five bacteria that most influence gum disease and dysbiosis that can affect the heart and other organ systems. The big contenders, P. gingivalis, F. nucleatum, T. denticola, there's AA, and then strep mutans too can affect the heart as well. But why do these bugs, how do they get where these other organ systems are and what are they doing?
Starting point is 01:15:48 So I like to term this leaky gums. So we've all heard leaky guts. So let's say we're just in dysbiosis and probably because maybe our oral hygiene isn't the best as well as some other things. So we're not flossing, let's say. And our gums bleed. Okay. That's a sign of inflammation, but you now have created a vector,
Starting point is 01:16:06 an opening in the skin, in the mucosa, where bacteria can get into the circulatory system, catch a free ride, and end up in places they shouldn't be. And that creates an immune response, so an inflammation. Okay, and then also these bacteria release endotoxins. Okay, they can create cytokines, storms, all kinds of things. inflammation, okay? And then also these bacteria release endotoxins, okay? They can create cytokines, storms, all kinds of things. So the body doesn't like these bacteria to end up where they shouldn't.
Starting point is 01:16:32 So heart disease, for example, if you have gum disease, you're twice as likely, two times as likely to have cardiovascular issues. If you have gum disease, you're three times more likely to have stroke. A lot of this is correlative, not quite causal yet, but some of these are looking to have more influence than others and there's more research that's needed. Fertility is a big one that I like to speak about. So women who have gum disease can take two months longer to get pregnant and to conceive. And there are studies that show in couples that can't conceive that 90% of the men show some sign of gum disease. And once they go in and get it treated,
Starting point is 01:17:15 then their fertility conception improves by 70%. That's significant, you know? And it's not only gum disease, but just any oral infection. P. gingivalis is being linked to Alzheimer's and dementia. These bacteria end up in the brain, they cross the blood-brain barrier, and they create amyloid plaques and inflammation in the brain.
Starting point is 01:17:37 And so there's been studies, many studies now, one big one was out of Harvard, where they sampled the cerebral spinal fluid in the brains and saw that in these plaques they had P. gingivalis of almost 100% of the patients. And when they tested them against other patients who had passed away without dementia or Alzheimer's, they didn't see any P. gingivalis. So there's a lot of association and links right now that we need more research on. The other to be aware of is cancer. And this is why I love people to consider oral microbiome testing.
Starting point is 01:18:09 I personally have a friend who we tested her oral microbiome and she was through the roof with F-nucleotum. Pretty asymptomatic otherwise, but F-nucleotum is linked to increased risk of pancreatic cancer, breast cancer, and colorectal cancer. I mean, we swallow 2,000 times a day, and we know some of these bugs, these bacteria, they can live through the stomach acid and make their way down into the gut. So...
Starting point is 01:18:37 Pancreatic cancer is, sorry to interrupt, I must say I've had a couple friends die of pancreatic cancer, and while I wouldn't want any cancer, that's the one that I really wouldn't want because so many of them are deadly. I have someone really close to me dealing with it right now. He actually just had his pancreas removed prophylactically
Starting point is 01:18:53 because it was pre-cancerous. The Whipple procedure. Yeah. If they catch it early enough, it goes anterior to posterior, and if you catch it early enough, they can lop off the anterior portion, the Whipple procedure as it's called.
Starting point is 01:19:04 But even a colleague of mine, a brilliant bioengineer, a few years ago, who had the Whipple done and he was progressing well, and then he passed away about a year and a half ago. Yeah, pancreatic cancer is- Don't wanna- No joke. And-
Starting point is 01:19:22 So if you could just test your spit, you know, it's a simple test. And I can give some of the tests that I like in the show notes, but you just spit into this little vial and mail it off, and then they send back your results with you. I mean, that's pretty amazing. You do need to find a dentist who can then guide you. What do you do with this information? A lot of these pathogens, they do need antibiotics. They're very virulent, they're spirochetes, so they're corkscrew shaped and they can just impregnate and wedge into tissue and so sometimes we really do need
Starting point is 01:19:55 to be pretty heavy hitting with how we treat them. So antibiotics. What kind of antibiotics are used to treat these things? It's usually an amoxicillin type of blend that they'll use. Okay, radical idea that's gonna get me in trouble with my more natural health audience, It's usually a moxicillin type of blend that they'll use. Okay, radical idea that's gonna get me in trouble with my more natural health audience, but I speak to those are there more pharmaceutical,
Starting point is 01:20:14 nothing, don't take anything. What is the argument against once every three years as a healthy adult doing a round of antibiotics to kill off unhealthy bacteria, replenishing the microbiome in various tissues. Just preventatively? Yeah, just preventative, like kill off what might be living in the mouth, like kill off what might be living in the prostate.
Starting point is 01:20:37 I learned recently that the prostate doesn't have the same sort of immune system protection. And so a lot of men, while they don't have UTIs, they have a prostitis and they basically just need to do a 21 day or 31 day round of antibiotics and everyone will be like, oh, you're spreading MRSAs with that or something, no, but you can protect against a number of different cancers
Starting point is 01:20:58 related to the prostate and things like that. Why don't we do this as a regular practice? Like every three years or so, you just kind of, you hit the system hard for about a week, kill off a bunch of bad stuff and a bunch of good stuff, and then replenish the good stuff. Yeah, it's a good question. I mean, I think it's harder to repopulate the gut
Starting point is 01:21:14 and the oral microbiome than one might think. I'd like a less is more approach. I think there's better ways to kill off bad things. Like ozone therapy is being used a lot I use ozone in my office. Tell me more about ozone. So ozone it's oh three. Okay, so it's a very unstable Molecule I use it in gas form or water. You can use it as an oil. It's carried usually in olive oil or hemp oil or flax oil And so it's antimicrobial, it's antiviral, it's antifungal.
Starting point is 01:21:48 And so what I'd use it for is to treat gum disease and periodontal pathogens, but then also under fillings or under sealants, or if I'm doing a pulpotomy or kind of a root canal procedure, because otherwise we're just blasting water everywhere. Wait, so is this oil pulling? This is the basis of- I use it as a gas.
Starting point is 01:22:08 It comes out of a machine and I use it in a wand as a gas. Very localized. I gotta try this, but what's the deal with people swishing olive oil and oil pulling? I know this is big in some of the, I don't even know what to call it anymore. What used to be alternative and it's now mainstream. It sounds like music in the nineties, right?
Starting point is 01:22:28 Indie medicine is now mainstream. They sold out, right? Like the, I'm just joking folks, but not really. It's, there's so many mimics between the health arena and kind of music and art. Like what used to be niche becomes trendy and then becomes mainstream. Everyone's cool with it now.
Starting point is 01:22:47 Yoga, breath work, resistance training used to be niche. Swishing olive oil, spitting it out. Acupuncturists love this. Alternative medicine types like this. Is there any truth to it? Does it relate to ozone? It can. So you can find ozonated oils on the market for oil pulling.
Starting point is 01:23:08 So this is an ancient aerobatic practice. Going back to ozone though, just killing off mycotoxins and bacteria, this can get kind of controversial, but a lot of natural paths will use gas ozone, either rectally or they'll use the IV too. You have to go to someone who knows what they're doing. Rectal ozone. Yes. To get all the way up to the oral microbiome?
Starting point is 01:23:28 No, it would affect more like the gut area, the pancreas, the liver, et cetera. Nothing shocks me anymore. It's used a lot with mold elimination, mycotoxin elimination. I get a lot of questions nowadays about mold toxicity, especially people in Austin. I don't know if you know this,
Starting point is 01:23:45 but like it's either theory or real that lots of people who live in Austin or used to live in Austin think they have mold toxicity. Because of a lot of new building architecture. They say a lot of the new buildings are too. The heat cold variation and the moisture. I don't know. I don't know if this is true or not,
Starting point is 01:24:04 but you know, the last thing you ever wanna do is tell somebody who thinks they have moisture. I don't know. I don't know if this is true or not, but the last thing you ever want to do is tell somebody who thinks they have something that they don't. And I'm not saying they don't. I hear this a lot. I've known a number of people that have left the city of Austin because they couldn't deal with the mold.
Starting point is 01:24:16 Interesting. Molding can be scary. I mean, we see it affect the teeth. The teeth will just start degrading too in some of the kids who have tested really high in mycotoxins. So rectal ozone. Yeah.
Starting point is 01:24:28 Wild. Well, hey, listen, it's the digestive tract. I mean, you know, we're a health science podcast. So everyone can look it up on their own, but there are providers out there doing it. So ozone can be great as an antimicrobial instead of an antibiotic. Now, going back to oil pulling, oil pulling is an ancient Ayurvedic practice. It used to be with sesame oil, more people do it with coconut oil now. I oil pull a couple of times a week occasionally. So what does that practice look like?
Starting point is 01:24:55 So I put a spoonful of organic raw coconut oil in my mouth, let it melt and just swish it around as I'm, you know, dawdling around in the morning. Nasal breathing. Nasal breathing. Yeah, don't spit it into your sink, it will clog your sink, spit it into the trash can. So what is it doing? Well, it's dislodging the biofilm as you're swishing, okay?
Starting point is 01:25:13 Loric acid, which is in coconut oil, is antimicrobial. It can help with lymphatic stimulation and it has some anti-inflammatory properties too. And a lot of people report it makes their teeth look brighter and whiter. It's nice. I mean, you do have great teeth. Well, I'll tell you the story why.
Starting point is 01:25:33 I mean, it's in your profession to have great teeth, but I walked in and I met you for the first time in person. I was like, wow, you have really, really nice teeth. They're not real. They're not real? I had facial trauma. Should we get into that? Yeah, let's get into that.
Starting point is 01:25:43 So when I was 10, it's why I became a dentist. When I was 10, I was trying to gain the attention of my older brother's friends who were very into dirt biking and BMX biking. And we had just watched the movie Rad and I thought I would impress them. And they were all doing tricks out in the neighborhood. And long story short, I fell off my bike
Starting point is 01:26:06 and landed on the asphalt in a vault and knocked out my teeth, and I broke my pre-maxilla, and you can see the scars still. But this is part of my story, and it's why I became a dentist, because I was in and out of dental offices and oral surgeons and orthodontists. And at the time, I was an art theater kid. I loved working with my hands. But as time went on, I thought, well, gosh, I don't want to be sleeping on couches in
Starting point is 01:26:30 New York City. I need to make sure I make a living. What am I going to do? And I really love science. And I thought, well, how do I work with my hands? And it was dentistry. And dentistry can be a little creative and artistic too. So these are not real, but thank you.
Starting point is 01:26:47 Well, you're welcome. And thanks for the full disclosure. They look very natural. Yeah, they did a great job. Unlike some people's falsies, you know, or whatever. What do you call them? I call them falsies, because I've got a tooth that was kind of chipped in half
Starting point is 01:26:58 from getting hit, honestly, dumb, you know. If you're going to box, make sure you're getting paid a lot of money. And you wear a mouth guard. Yeah, and wear a mouth guard. There are better martial arts where you can go full blast, like Brazilian Jiu-Jitsu, where you stand less of a chance of brain injury,
Starting point is 01:27:16 let's just say. So as a neuroscientist, I can't support boxing, but I remember the movie Rad. I remember the back flip at the end. I remember the whole thing. I think I was trying to do that. I don't know what I was doing. Anyway, didn't land it. Yeah, well, you landed it, but on the rock, but...
Starting point is 01:27:32 So this is a bridge. You can get implants. People have flippers. We were talking about hockey players earlier. You'll see them flipping their flippers around with their fake teeth. So a flipper is a retainer with fake teeth on it. There's a lot of different things you can do.
Starting point is 01:27:49 But what's interesting, I was part of making my teeth. I sat in the lab and helped. So I wanted them to look not quite as contrived, I suppose. Well, they look very natural. Yeah, thanks. And today we're learning all the ways in which teeth are just part of this whole ecosystem that's so critical.
Starting point is 01:28:06 I have to ask, and we will come back to some things related to avoiding really horrible diseases by way of taking better care of one's oral health. Nicotine. These days, everyone knows or should know that smoking, vaping, dipping, and snuffing, and yes, I did say vaping, are all terrible for your health. The vapors will say it's not personagenic, cancer-causing, and I'll say remains to be
Starting point is 01:28:38 made really clear, but the whole popcorn lung thing is clearly problematic. But nicotine doesn't cause cancer. It's the delivery mechanism. Yes. But these days, a lot of people realizing the cognitive enhancement, if you will, I don't even like the phrase, the stimulant effect of nicotine
Starting point is 01:28:59 are using nicotine pouches in particular, gums. Let's set patches aside for the moment and mints and things of that sort for the stimulant effect. It's an unusual stimulant because it also relaxes oneself a little bit at the same time. So it's kind of that like, you know, that sweet spot. And I confess, I will occasionally take, you know, one or two milligrams, very low dose.
Starting point is 01:29:26 Most pouches are anywhere from three to eight pouches, milligrams rather. I'll take, you know, like one to two milligrams of nicotine in the form of a gum. I'll just chew it, you know, and then take it out. Nicotine is a vasoconstrictor. What does nicotine do to the oral microbiome? Are you gonna make me quit nicotine?
Starting point is 01:29:46 I don't feel addicted, but every addict says that, so. The first step is admitting the issue. So I don't wanna villainize anything. No, you can villainize it. So I agree with you, I don't think it's the nicotine itself, but like the pouches, for example, are becoming very popular.
Starting point is 01:30:05 So what else is in those? And there's a really interesting case study that maybe we can link it for people to look at and I'll share it with you later. And then I have colleagues who are reporting this all throughout the globe, but they're one brand in particular, it will have Manitol and maltodextrin in it, which are sugar alcohols and a different carbohydrate, and they market them as sugar-free. Well, products are allowed to have trace amounts of sugar still in the product, very small amount and still be called sugar-free.
Starting point is 01:30:42 And the issue with these products is the duration of action, the contact time. I mean, you're supposed to leave them in for 20 to 30 minutes, am I correct? That's right. So it's quite a long time to have that up in the mucosa, along the bone, and along your teeth that potentially has some sugar in it, okay? So it's like if you're sucking on a hard candy. But also we're seeing changes to the cellular structure up in that area. So you can see leukoplakia, which is like white patching, which can be precancerous. So this is why
Starting point is 01:31:16 I just like everyone to get checked out. And we are seeing bone loss and gum recession. Again, anytime you put anything into the mouth, it's going to change and shift the microbiome. And that could be a filling, that could be a piece of gum, that could be a toothpick, anything, arguably besides neutral pH water. And so this case study, this gentleman was going in, I believe he was in his mid-50s, he started using these
Starting point is 01:31:46 pouches and had always had very wonderful dental checkups with x-rays and went in regularly and maybe he missed one appointment and after 15 months of use, the x-rays are outrageous. He has rampant decay along the side where he had the pouch, very likely from potentially that trace amount of sugar, the microbiome changes. I mean, it looked like mothball chunks taken out of his teeth and he lost some teeth. Wow.
Starting point is 01:32:16 So this isn't to scare people, but if you're gonna choose to use these, I just say know the risks and make sure you're getting checked regularly at your dentist. Don't just ghost your dentist because if they're starting to see cellular damage to use these, I just say know the risks and make sure you're getting checked regularly at your dentist, don't just ghost your dentist. Because if they're starting to see cellular changes, recession or early decay, then you may say,
Starting point is 01:32:34 gosh, I should really cut back on this. Or maybe if somebody is really adamant about taking nicotine, they should just take a milligram or two milligram pill of nicotine. Yeah. Or a patch. Right. You scared me with leukoplakotine. Yeah. Or a patch. Right. You scared me with Leucoplakia.
Starting point is 01:32:47 Yeah, because growing up, we were all told, no one really dips in Northern California, but don't dip or, because, and then I saw these pictures of Leucoplakia. Jaw recession. Jaw recession, and it's pretty vile. And so you, the design is scary. It scared me sufficiently. I never wanted to chew tobacco anyway, but good to know.
Starting point is 01:33:10 Coffee, do I need to stop drinking coffee? Okay, thank you. You're from Portland after all. Or near Portland. How could I possibly say that? Okay, yeah. You wouldn't be able to return home. Coffee's great.
Starting point is 01:33:21 I mean, it will dry out the mouth a bit, just counteract it with hydration, and it will stain your teeth. So go in regularly for cleanings, and you may want to, I mean, if that bothers you, there are ways to bleach your teeth or lighten your teeth. Hydroxy apatite is a wonderful way to improve the brightness and whiteness of your teeth and oil pulling as well. Or you can use heavy hitter bleaches too. Just don't overdo it. Everybody's overdoing everything now.
Starting point is 01:33:50 And bleaching too much can damage your teeth. It can cause chemical harm to the pulp or the nerve over time. And some people will get spontaneous abscessing or need root canals. I mean, these are people who are really bleaching all the time, the people who, you need sunglasses to look at their teeth and it's just not really a natural aesthetic. But some people are into that, but just know what the risks are, is what I would say.
Starting point is 01:34:15 The two things I've done in the last couple of years that have completely transformed my oral health, says my dentist, and how I feel are, first of all, I switched a few years ago, I would say really about 14 months ago, I just said, that's it, I'm not eating processed foods again, I'm just not gonna do it.
Starting point is 01:34:33 So I eat meat, fish, eggs, fruits, vegetables, and I eat some rice, oatmeal, and a good sourdough bread, butter, olive oil. Which is not to say that I won't have a slice of pizza someday, but I just, I was like, that's it. Like I'm kind of over it. 49 years old, I've eaten enough of that stuff.
Starting point is 01:34:50 I'm kind of like bored with it anyway. I hear you. And what was interesting is I used to get a lot of tartar buildup a lot despite brushing and flossing on the, what are the lower front teeth called? Incisors. Yeah, and it was, and they'd scrape it away. It's a non-issue now.
Starting point is 01:35:06 Interesting. Like it's completely gone. Yeah, so we have minor salivary glands on the floor of our mouth, and that is a common place people will see calculus or tartar is those lower teeth. That's where you'll feel your hygienist scraping a lot. But I wonder if it's because you increased your K2
Starting point is 01:35:21 in your diet, which helps with calcium metabolism. And I supplement K2, but I was doing that before. And then I switched and I have just full disclosure because there's nothing to disclose. I have no financial relationship to the toothpaste that you make or the toothpaste that Gator Dentist makes. I don't know who, I actually know his real name, but he hides as Gator Dentist.
Starting point is 01:35:42 I love Gator. Gator Dentist. But I Gator. Gator Dentist. But I switched from fluoride containing toothpaste, not because of fear of fluoride, but excitement about hydroxyapatite. So I switched to using your toothpaste. And I occasionally, well, I routinely switch back and forth with NOBS,
Starting point is 01:35:59 where I think it stands for No B.S. Which is Gator Dentist's tooth tablet product. So I use them and neither of them pay me, I pay full price. They don't send it to me, I purchase it like anyone else. And that's made a tremendous difference, says my dentist, like no cavities whatsoever. I was constantly battling this when I was a kid and a bunch of oral health issues.
Starting point is 01:36:20 And I don't wanna waste our time talking about those right now, maybe we'll return to them a little bit later. But my teeth and oral microbiome never felt better. It's just remarkable. Yeah. It's just remarkable. And I have a family member who has some gut issues, like just digestion issues, and it's unclear what's going on there.
Starting point is 01:36:39 And I'm inspired to try and help them address that through the oral microbiome by switching to hydroxyapatite and- And test their oral microbiome. That'd be very interesting to know what's going on in there, because I think you're swallowing- Is there a best test? Sorry. Is there a best test?
Starting point is 01:36:56 Because a lot of listeners are going to say, okay, if they have the disposable income, they're going to want to test their oral microbiome. Is there one that your office uses or that? I use either the SILHA test, which is more just biomarkers. So it's a- How do you spell that? S-I-L-L-H-A. This is done in an office. It's just testing basic biomarkers.
Starting point is 01:37:16 So I use it a lot as an educational tool. It will show the pH, the acidity, if there's leukocytes, if there's red blood cells, inflammatory markers. So a lot of parents, this is so new to them when I'm talking about this. But it prints out in a graph form for them. It's a cheek swab? Spit.
Starting point is 01:37:35 Spit, so kid or adult will spit in your blood? Yeah, kids usually won't spit till about four, just physically. It's hard. It can spit until you're four? Yeah, it's hard. Okay. Anyway. But I really like tests that use shotgun metagenomics
Starting point is 01:37:47 because you're looking for the whole array of bacterial DNA. And so my favorite is bristle, like a toothbrush bristle, and it's direct to consumer. So, because the issue is I can talk about all of these things, but sometimes it's hard to find providers
Starting point is 01:38:02 that are offering them. So I really love people to be able to get the tools in their home. So Bristle is a company that people can- It's an oral microbiome test, yes. And it's really user friendly. Their interface is wonderful and they will give guidance and protocols. Are you affiliated with them? I should probably ask because some of the audience will-
Starting point is 01:38:22 I am actually, yes, I am. That's fine. As long as people know. They're oral probiotic. We have a collaboration with their oral probiotic. But regardless if it's bristle or not, you look for a test that's using shotgun metagenomics. Shotgun metagenomics, okay. There's PCR testing too, and a lot of biological dentists will offer something
Starting point is 01:38:42 like oral DNA is the most popular. The issue with that is it's really only looking at the top 12 pathogens, periodontal pathogens, which is important, but there can be a lot of other information that you're missing. So it's a great place to start and your dentist may offer that. It's called, again, it's oral DNA
Starting point is 01:39:00 and I have no affiliation with oral DNA. Great, thank you for that. I think some people will want to test their oral microbiome and other things in their mouth. And there's more and more popping up. Like if the oral microbiome is really blowing up. So for those who are looking for investment opportunities, I'd say look toward the oral microbiome.
Starting point is 01:39:22 It's kind of what the gut microbiome was doing a decade plus ago. Yeah, I feel like oral microbiome is so much more tractable. I mean, switch to nasal breathing, get away from alcohol containing mouthwashes, consider a hydroxyapatite containing toothpaste instead of fluoride, which brings us to fluoride. Let's talk about fluoride. I've already been accused of being a sunscreen denier. No, I actually believe that sunscreen exists. I do occasionally use zinc oxide sunscreen a little bit.
Starting point is 01:39:52 I prefer a physical barrier because I'll wear a hat or something. If I, you know, I don't tend to burn very easily, but if I feel like I might burn, I use a physical barrier. I'm being somewhat facetious here because people will say all sorts of things, but I did an episode about water, a little bit about oral health,
Starting point is 01:40:12 certainly not the depth or expertise that you're providing today, so thank you. And I said, yeah, fluoride does a bunch of things. My question was, and remains, why are we drinking fluoride? But this relates to, okay, I'll tell this story briefly. It's not as cool as your story. I was taken to a dentist when I was a kid, and they put me, they put these like a mouthpiece
Starting point is 01:40:39 with fluoride gel in it on the top and bottom, and they sat me in a little wicker chair in front of a TV with cartoons. And I hated it. It tasted awful and it kind of like had this sour thing. So I, it was probably six or seven. So I drank it. I just sucked it up, drank it down, turned around,
Starting point is 01:41:00 barfed all over the wicker chair. Oh my gosh. Fluoride's a poison, but everything is a poison at high concentrations. So, most everything is a poison, excuse me, at high concentrations. So I don't have anything against fluoride, but it is a poison.
Starting point is 01:41:17 Then the question becomes, if something is not dangerous in a small dose or concentration, what are its cumulative effects? This is what I have issues with. People say, oh, going through the x-ray machine, no big deal, but what if you fly 150 times a year? Is it cumulative? And so like the logic of the sort of pushback
Starting point is 01:41:37 from the traditional, if I will, community sucks. Like they're just not logical. These are my colleagues sometimes too, right? Just you go to the dentist to get an x-ray, they're like running behind the next wall, put you in a lead shield, and then they're like, oh no, it's no big deal. Well, how many, you know, maybe how many times a year
Starting point is 01:41:54 can you do this before it becomes a deal? So my question is, what is the rationale for putting fluoride in water, in drinking water, given that the contact time in the mouth is so short. And then what's the cumulative effect of bringing fluoride into the gut over and over? And then earlier you said something, and I've never thought about this.
Starting point is 01:42:17 The bones contain hydroxyapatite, 60%, I think you said. 60% of your bone minerals are made from hydroxyapatite. Fluoride infiltrates the minerals of the teeth and replaces it, so is fluoride going into our bones? Skeletal fluorosis. Okay, so I'm not trying to paint a scary picture here, but frankly, and people can probably tell, my blood pressure goes up a little bit when people say,
Starting point is 01:42:40 oh, you know that you're anti-fluoride. I'm not anti-fluoride, but I just don't get the logic. It doesn't make sense. You're thinking critically about it. Like, why would I continually bombard my system with fluoride at the level of the gut, at the level of my bones? If it's good for me, tell me it's good for me.
Starting point is 01:42:57 But they're saying, oh, it's so that poor populations don't have decaying teeth. Sounds like a good argument, not even counter arguing it, but I can't piece together the logic. And like most public health arguments, I feel like neither side is explicitly clear about what exactly they're arguing about. And that's part of why I have this podcast,
Starting point is 01:43:20 to try and get clarity on things. I'll do my best. Yeah, and please don't worry that you're gonna offend anyone because I'll offend everybody and they've already said anything, everything they possibly could and they'll say more. So I'm not afraid to open up these topics anymore.
Starting point is 01:43:34 Well, I appreciate that. Yeah, and I'll take the heat. Well, I will get it too, don't worry. I've already, I have thick skin at this point. But you have great teeth and they don't, so. Yeah, and I haven't had a cavity for multiple decades and haven't used fluoride. And Portland isn't fluoridated. Portland is not fluoridated?
Starting point is 01:43:52 It is not. So let's talk about that. So, fun story. Back in 2011, 2012, I was working on the pro-water fluoridation campaign, volunteering in Portland, picketing and handing out educational flyers, because I thought we needed it in our water. And this is because that's how it was trained. And I just never questioned it. I never picked up a journal to look at the other side.
Starting point is 01:44:21 I thought anyone speaking out against water fluoridation, that's the tin hat brigade, that's the woo woo caucus, all the things. I was that person. The woo woo caucus. Yeah. That's pretty funny. Yeah. So I went to a debate in Portland, pro versus against. I don't like those terms, but it's just the easiest way to describe it.
Starting point is 01:44:44 And I was sitting kind of on the pro side and just waiting to see these pseudoscientists come out to speak. And I was so profoundly impressed with what they said and also had no idea that there were any concerns with fluoride. I had never been taught that in dental school. The endocrine disruption, the neurotoxicity, the skeletal fluorosis. I knew about dental fluorosis,
Starting point is 01:45:10 but I, at that point, was of the mindset, well, it's just the static, but your teeth are stronger. And the microbiome issues too. So it didn't take long, I just started rabbit-holing. And there's so much literature. And this, again, this was quite a while ago, and more and more data and literature is coming out to question the practice.
Starting point is 01:45:30 So it's important to go back to the history of water fluoridation, I'll try to be brief, but in the early 1900s, there was a dentist in Colorado Springs, Frederick McKay, who noticed his patients had modeled brown spotted teeth, but they were really strong, They weren't getting decay. And so this kind of spread and they started kind of trying to understand the why. And they realized there was a really high concentration of fluoride in the natural water
Starting point is 01:45:57 supply that this community was drinking. And this just kind of spread like wildfire with very little evidence-based medicine to back it because this was in the early 1900s. Now it was like the 1930s. So no long-term safety studies or efficacy studies. And it was put in as an experiment in Grand Rapids, Michigan in the mid-40s. After about a decade or so, they noticed that caries rates, cavity rates were going down. And so based on this observation, it just went like wildfire throughout the United States.
Starting point is 01:46:31 And I believe about 80% of the United States is Florida. So the pro-advocates, if you will, will say it's the greatest public health movement of the century because decay was such an issue, it's important to know dental decay is the top chronic disease globally in children and adults. It's almost entirely preventable. I think we've just normalized it. You just get cavities, but I'd like to point out we're one of the only species to get dental decay. Wild animals don't get decay. our domesticated animals do, because of what we're feeding them, the kibble, you know, processed animal food.
Starting point is 01:47:10 So here we are. So it's been controversial from the beginning. You know, epidemiologists, endocrinologists, neuroscientists have always challenged it, saying, this is a bad idea, it's a highly reactive element. You know, the fluoride ion can interfere with iodine uptake and again skeletal fluorosis, neurotoxicity, et cetera. About seven years ago, there was a federal trial in Northern California, but it was federal,
Starting point is 01:47:41 the People versus the EPA, it was a TASCA trial. And this has been ongoing for the past seven years, and basically they were saying, where is your safety data, EPA, on the long-term effects of water fluoridation? So the idea was that if we put it in the water, it's not a very efficient way to get fluoride to people, but eventually it will make itself into the saliva and have a topical effect coming out through the saliva. They used to think systemically it was actually incorporating into the developing teeth and children, making the enamel stronger that way, but that's been debunked.
Starting point is 01:48:19 So now it's most likely still a topical benefit, maybe a little bit of a systemic benefit, touching the teeth. And we do know fluoride really needs to work topically. We don't need to be ingesting it. And that is all through the data. And they're teaching that in dental schools now too. Okay? But this is the easiest way to get fluoride to the masses because caries or cavities are
Starting point is 01:48:42 such an issue. Now, my first comment on this is we're not addressing the root cause of dental decay, which is our food. It's all the ultra-processed foods. Again, we didn't really see dental decay in humans until the agricultural revolution, the industrial revolution, and now the ultra-processed food craze
Starting point is 01:49:00 that's been happening the past many decades, okay? Is that right? So if we look at skeletons from dead people, obviously. Well, you can look at skeletons of live people. Skeletons and dead people, from dead people that died prior to 1900. How are their teeth? 1900, they still have, they would have decay. But if you looked at about 10,000 years ago, very little.
Starting point is 01:49:26 You know, Leslie lived in an area with a lot of fruit abundance or honey, like where are you getting your sugar from? You know, and you go pick some berries on a bush, you're competing with the animals and the birds, you didn't have much opportunity to over consume sugar. But you know, there was the sugar trade and then we just, sugar was a sign of wealth and royalty and people's teeth just rotted out and it was because of our diet. So that's the root cause issue that no one's talking about. You know, we're just saying, let's slap fluoride on it.
Starting point is 01:49:56 How about we educate and teach people what is really causing cavities? But anyway, okay, so the TASCA trial was going on and the judge, Judge Edward Chen, was waiting for this National Toxicology Programs report, which was under the Department of Health and Human Services. And this is, it reads like a soap opera, to be honest with you. And it kept getting delayed and postponed and they wouldn't release it. And finally, under the Freedom of Information Act, he said this needs to be released and it said there is a strong correlation between increased fluoride consumption and IQ issues in children.
Starting point is 01:50:39 And so with that, he took this information and he made his ruling. Now this was after years of expert testimonies as well, okay? And so with that, he took this information and he made his ruling. Now this was after years of expert testimonies as well, okay, saying there's an unreasonable risk to current water fluoridation practices in the United States. This was his ruling that just happened late last year. I mean, this is very new. And EPA, you now need to fix this. You need to regulate this better. What people will argue
Starting point is 01:51:06 is a lot of the studies they were looking at that are showing lowered IQ in children or neurocognitive issues, it was at 1.2 or 1.5 milligrams per liter. That was the concentration. The United States, we now do 0.7 milligrams per liter, but that's per liter. So how many liters of water do you drink a day? This is the controversy. So for example, the American Academy of Pediatrics generally recommends pregnant women drink two to three liters a day. You might be cooking with fluoridated water, making your pasta, making your soup.
Starting point is 01:51:46 How do we really know how much someone's getting exposed to? What's their body composition? How much do they weigh? What are the other outside sources of fluoride? Are they swallowing their toothpaste? Fluoride is in many pharmaceuticals because it helps increase bioavailability, especially SSRIs and Prilosec. A lot of these have fluoride in them.
Starting point is 01:52:08 Really? Yes. Ultra-processed foods will have fluoride. So the factory that's making your rock star energy drink or your high C or whatever you're consuming, they're not using reverse osmosis to filter the water. So you're getting fluoride that way. It's naturally found in green tea and black tea.
Starting point is 01:52:28 And this is not to make people worried about green and black tea. I still consume them. It's more to say, how are we really understanding how much is exposed to? And so they were finding that pregnant women, they follow, there's many studies now, but a famous one was the RIFCA Green Study out of Canada, and they followed about 520 mother-child pairs.
Starting point is 01:52:51 They tested urinary fluoride, and the mother per trimester averaged it, and then followed these children to the age of three or four and did IQ tests and found that mothers who had higher concentrations of urinary fluoride, the children tested lower on their IQ test up to five to seven points, and that's on par with lead, okay? On par with lead. On par with lead, yes. And so that was in 2019.
Starting point is 01:53:16 There's been so many more studies now. So the judge ruled, EPA, you need to regulate this better. In that amount of time, there was a meta-analysis that came out that further supported the NTP report by JAMA Pediatrics. This is very controversial for these editors to be putting out, by the way, so I commend them. And also a Cochrane report came out, Cochrane Collaborative, which has said, this again was very recent, looking at all the data from water fluoridation, water fluoridation isn't reducing decay like we
Starting point is 01:53:51 thought it was. It's only reducing decay by about one quarter a cavity per person. One quarter of a cavity per person. So that's not statistically significant. So people will say, well, what gives? Why were cavity rates going down when we added fluoride to the water? Well, it's hard to say. Maybe they were already just going down due to education, more access to dental hygiene and tooth brushing, flossing, but also we now have fluoride everywhere in our toothpaste.
Starting point is 01:54:26 So fluoride was put in the water in the 1940s. It wasn't added to our toothpaste until the 1960s. Now it's everywhere. We get fluoride everywhere. Rinses, the varnishes that made you vomit at the office. And by the way, that's very common. That's very common. And it's because a lot of those fluoride varnishes,
Starting point is 01:54:46 number one, fluoride, you know, it does have a poison control label on it. You're not supposed to swallow it, but these varnishes also have polyurethane and hexane derivatives in them. It's what makes them so sticky. I still loathe going to the dentist. I know that flavor.
Starting point is 01:54:59 I think it's because of that early association. Yeah. Yeah. So it's very controversial and unfortunately, we've lost sight of the science, it's getting buried in politics right now and it really upsets me because it's not a political issue, we just need to look at the data and I feel like we're losing sight of the scientific method.
Starting point is 01:55:19 The American Dental Association, the American Academy of Pediatrics is doubling down on saying we have to put fluoride in the water. And for nothing else, I think it's important to know 97% of the world does not fluoridate their water. This is a very United States controversy. Many countries removed it and found, I think it was Denmark, Germany, Japan, they have
Starting point is 01:55:42 very low decay rates. And why is this? Well, they educated their population on what's really causing decay and also made fluoride toothpaste accessible. And I have Danish relatives, they have very nice teeth. If you told me that there's no fluoride in the drinking water in England, I might be like, well, you know, sorry, my English friends,
Starting point is 01:56:01 but that's the stereotype, right? That their teeth are bad. I don't think that that's true any longer. I think that that was true at one point. I think they're crowded and crooked too, and a lot of that has to do, I think, with facial development as well. I think we see a lot of Western European,
Starting point is 01:56:19 they do have that kind of dysmorphic face, if you will, probably from nasal breathing. Who knows why? Industrial revolution, allergies, breath breathing, et cetera. Why does it seem more prevalent there? So that's the quick take on it. And so I just think it should be a personal choice. If you want to use fluoride, you can go out to the store.
Starting point is 01:56:42 You can get fluoride toothpaste at the dollar store now. They give it out for free at many clinics. To me, I just think it's a medical ethical issue. We're mass medicating a population without their consent. And then the even bigger issue for me is no one's talking about this, nor can I find any literature on it. What is it doing to the gut microbiome? Because it is an antimicrobial.
Starting point is 01:57:08 So that would be a wonderful study, NIH, if you're listening. Can we test people that live in fluoridated areas versus those that don't? Can we follow them? Maybe it's a prospective cohort study to just see how their microbiomes are different. Because it just doesn't make sense to me.
Starting point is 01:57:24 And why would we ingest something systemically with all these potential risks when we could just use it topically or actually talk about what's really causing decay? If fluoridation worked, cavities wouldn't be the top disease in our country, in our children. And many worry, well, if we take it from the water,
Starting point is 01:57:44 decay may go up. And it may. I mean, there's been, they did this in Calgary, Canada, where decay rates went up, but then if you actually look at the data, the decay rates were already going up when they removed it, but they only show you the data that they kind of want to show you for that. But again, it's a risk-benefit analysis. I mean, I think dentists tend to be too focused on teeth. And so you mentioned, like, if they say, it's good for me, I'll do it.
Starting point is 01:58:13 Well, good for what? Good for your teeth or good for your whole body or good for your brain? And I think that should be an individual choice. As a parent, do I want to choose one quarter less cavity in my child or do I want to preserve their optimal brain development? I mean the data that show deficits on par with what one sees with lead exposure, that's the most striking thing to me.
Starting point is 01:58:42 Yeah. And I'm a dentist. I was trained to fix teeth. I can fix a one-quarter cavity in a tooth. I can't fix a developing brain. We have one shot to develop a brain. We have one shot to grow a face. It's really important.
Starting point is 01:58:55 Well, I really appreciate you taking us through the full arc of the history of it. I think it's extremely important that people take that in so they can start to form their own opinions. And you pointed out a number of logical flaws in just the way the whole system is arranged right now, which is this mass treatment of everybody with a potent chemical, especially given the amount of water that people drink and cook with, et cetera, without their consent.
Starting point is 01:59:30 And without a risk assessment. So your low decay rate, I might be a really high decay rate. You don't need anything extra. Your diet, your balance, your microbiome's great. I'm not eating well. My hygiene's terrible. We can't just blanketly be treating everyone the same, we're supposed to be doing risk assessments. I'd like to take a quick break
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Starting point is 02:00:36 and I drink that basically first thing in the morning. I also drink element dissolved in water during any kind of physical exercise that I'm doing, especially on hot days when I'm sweating a lot and therefore losing a lot of water and electrolytes. They have a bunch of different great tasting flavors of element. They have watermelon, citrus, et cetera. Frankly, I love them all. If you'd like to try element, you can go to drink element.com slash Huberman to claim a free element sample pack with the purchase of any element drink mix. Again, that's drink element.com slash Huberman to claim a free sample pack with the purchase of any element drink mix. Again, that's drinkelement.com slash Huberman
Starting point is 02:01:05 to claim a free sample pack. Okay, so I think that pretty much puts fluoride in a, not in a box, let's say on the shelf for all of us to look at. I think this is going to be a very important aspect of public health in the year to three years to come with this new administration and Bobby Kennedy paying a lot of attention to fluoride.
Starting point is 02:01:27 And I really like what you said about trying to remove the political aspects of this. If this becomes a blue versus red, left versus right thing, we're never gonna get to the heart of the matter. And that would be really sad. And the ones that would really suffer would be kids. The children, yeah. So a nonpartisan look at this, which is how I heard everything that you said, just seems
Starting point is 02:01:54 really critical. Where are they getting the fluoride? So water fluoridation, the fluoride that they get is a byproduct of the phosphate fertilizer industry and it's called hydrofluorosilicic acid. So as a byproduct of the phosphate fertilizer industry, it's considered a hazardous waste and it's very expensive to dispose of. But they have found that if diluted in theory and put, it's an acid, first of all. So if it's put into our water system, it is so diluted that it becomes safe.
Starting point is 02:02:34 But I will say, everyone can go research this and look at themselves, but it does come in like cement bags with skull and crossbones on the front and they do have to wear hazmat suits to put it into our water. They're supposed to titrate it and I think what's interesting, you know, we're supposed to target 0.7 milligrams per liter. I've been involved in some educational campaigns and have tested communities surrounding Portland. It's very hard to keep it in range, you know, and so there are some communities testing as high, we've seen as 2.2 milligrams per liter,
Starting point is 02:03:09 which definitely falls into, based on the science and literature, more concerning zone for neurocognitive issues and other health issues. So if you're concerned, you can call your local water bureau, municipality. I will say, I don't think the federal government's going to have much control over this.
Starting point is 02:03:28 It would be nice if the EPA stepped in. They have appealed, by the way. But it will come down to more on the state level and local level. And we're already seeing states like Florida and Utah have run it through and initially done a, we're going to ban this as a mandatory thing in our state. And I think it's North Dakota, Kentucky, there's other states picking this up too, and other communities that are removing it or not adding it to their water.
Starting point is 02:03:59 So it's an interesting time to observe all of this. Super interesting. I will resist the temptation to ask questions about why it sounds like mostly red states are the ones doing this as opposed to blue states, although Portland is in a blue state. Portland's traditionally- Blue city for sure. Blue city. Yeah. Right.
Starting point is 02:04:19 Blue city in a- Red state. When Oregon went red this last election? The cities make up, it's kind of like many states. So Eugene, Portland, Bend tend to be pretty blue. And I think the surrounding is more conservative. But no, it shifted a bit, but not enough to shift out of voting liberal. Okay.
Starting point is 02:04:40 All right. Well, we'll do another episode in 2090 about politics. Meanwhile, back to the oral microbiome and otherwise, I'm very interested in the relationship between oral health and what you described as fertility, pregnancy, and hormones. And obviously hormones can be about men or women, but let's talk about oral health and fertility.
Starting point is 02:05:09 What if any knowledge is there about how the oral microbiome or oral health would be impacting egg health, fertility, ovulation, ovarian reserve? Is that the sort of the level that the regulation of fertility is thought to occur? Like what's known about the link? Yeah. So again, it ties back to that translocation and creating an immune response and inflammation as well as the endotoxins that are released. With men particularly, they're seeing increased sperm challenges with sperm motility and sperm
Starting point is 02:05:42 mobility as gum disease and periodontal pathogens increase and again it probably it has to do with the inflammation and with women you know it we can show that women take about two months longer to become pregnant. It does affect ovulation, egg quality, but also we know it can lead to miscarriages and low-term birth, low-weight birth, preterm birth, and just pregnancy complications as well. And so we are finding oral bacteria in the placenta. You know, we're finding there's different microbiomes everywhere now. The breast has a microbiome, the placenta has a microbiome.
Starting point is 02:06:25 And so oral bacteria can end up in many of these places and just create that cascade of inflammatory events. And so certainly it's an exciting time to be alive because of all the research happening. And right now it's, again, not causal. There's a lot of correlation. But I would love to see fertility clinics focusing more on oral health.
Starting point is 02:06:45 Like how amazing would it be if they started testing the microbiome of patients and if they realize they're really high in P. gingivalis or F. nucleatum and they eradicated or lessen that bacteria. I mean, it'd be interesting to see how pregnancy and fertility outcomes would change and possibly improve. Great. What are some of the mechanical as opposed chemical, things that we can do to improve our oral health?
Starting point is 02:07:10 So we were all taught brush and floss twice a day. I even have a colleague who can be caught in the bathroom brushing his teeth after lunch. So he's brushing three times a day. I don't know what motivated that. I do that too. Do you? Okay. Great.
Starting point is 02:07:29 So what's the deal with brushing? When, let's say, kind of like exercise. Let's say if someone were gonna only brush once a day, better to brush in the morning or at night. Obviously people should brush twice a day, but more more. But if one could only brush once a day, would it be morning or night? Yeah, I guide parents on this a lot because brushing a child's teeth can be challenging. Nighttime is always the most important.
Starting point is 02:07:55 One, you're removing the food particulate matter from the day away. You're disrupting that biofilm so that you're not sitting, sleeping all night, eight, 10, 12 hours if you're a child, with that sticky, potentially dysbiotic biofilm on your teeth, and then you add in maybe your mouth breathing, that's gonna shift the microbiome and drop the pH more. So it's really nice to go to bed with clean teeth. So I suggest focusing on the nighttime. What does drive me a little bonkers is the fact
Starting point is 02:08:26 that we tend to focus so much on brushing, but we leave out flossing a lot of the conversation. So thank you for mentioning that. If you read children's books, you'll see they all say, go brush your teeth, but never floss. So we need a revamp there. But most cavities that I see in children, and this translates to the adult population
Starting point is 02:08:45 as well, are in between the teeth or interproximally in the molars. And it's really common. So a lot of parents will bring their kids in. They think they've been doing everything correctly. They haven't been flossing quite yet. And we take x-rays for the first time and the children have eight cavities, which sounds like so many, but it's really common because we have eight molars. And so it happens between the teeth where you're eating those goldfish crackers, those pretzels, those chips, they get stuck in between the teeth,
Starting point is 02:09:15 the bacteria come to feed, the acid gets released, and it just sits there hour after hour, day after day, arguably week after week if you're never flossing. So I really like flossing to be part of the routine too. Again, if you can only do it once a day, that's great. That's fine. Do it at night. I like to floss first, then brush. Um, you're dislodging the food in between and kind of brushing it away. There's actually studies to support this too, that order.
Starting point is 02:09:41 However, beggars can be choosers. Just do it. You know, some people get a suction choosers. Just do it. Some people get a suction cup mirror, they'll do it in the shower. Some people do it in their commute in the car. I'm not going to be picky about it. I will also say as we age, flossing doesn't always cut it by itself. So think about a little string of floss.
Starting point is 02:10:00 We want to put it between the teeth and they suggest you do a C and a backward C. You're scraping the sides of the teeth to disrupt that biofilm. But as we age, we all lose a little bone. So you get this little pocket where that string isn't cleaning the bacteria out of, and that's where a water pick can come in. And so if you really want to be an overachiever, I do love a little water picking too. I personally will alternate. So one night I might floss, the next night I might water pick. This works really well in patients that can't put their hands in the mouth, maybe they have like an aversion
Starting point is 02:10:34 to that. Sensory children often will struggle with flossing, so water picks can be fun. You can do it in the bathtub so it doesn't get totally messy or in the shower. They make cordless versions But I can't over emphasize how important flossing is that interproximal cleaning It stimulates the gum tissue and and you're less likely to have gum disease as a result What about those little toothpicks with a little sling of floss across? You know that the hard picks that... Yeah, floss picks. Floss picks. They're great, especially in kids.
Starting point is 02:11:10 It's the only way to floss a child's teeth, first of all. So I want parents, as soon as teeth touch, they should be flossing. That could be the anterior teeth. Our jaws are shrinking, our teeth are crowded. It's rare for me to see a child with space in their front teeth. That is how we should be developing because adult teeth are wider than baby teeth. They need more room to come in, but very often we're crowded. So anywhere teeth touch, we should be flossing, but usually around the age of two and a half,
Starting point is 02:11:37 the molars are in touching. And parents look at me like I'm crazy, but we really should be flossing. And so if you start some of these behaviors early, it becomes easier and easier. We know kids that floss become adults who floss, but also floss picks are fine for adults too. Some people have big hands, it's hard to get floss in. I have to use them.
Starting point is 02:11:58 I can't get into my hands into my mouth. They're fine. Yeah, okay. You just wanna try not to just go straight up and down, just kind of angle, angle if you can. Okay. And then maybe a water pick too. And I was told by my dentist, soft toothbrush,
Starting point is 02:12:13 cause I tend to get in there and like, I'm hearing all this stuff about how the, you know, oral health is so important for the brain and for any of that could lead some people, including me to get in there and just start like scrubbing and scrubbing and trying to get everything out of there. And that's not the right approach. Brush stroke, very gentle.
Starting point is 02:12:29 So you wanna do gentle circular movements. You don't wanna wear away your enamel. This is also important. Many people will eat and then run to the bathroom and brush their teeth. Every time we eat, our teeth demineralize a little bit. Remember I mentioned it takes about 20 or 30 minutes for that remineralization to begin.
Starting point is 02:12:48 So if you're immediately going to brush, you could be, your bristles could be damaging your enamel and creating, just wearing it away and creating little marks and it could lead to sensitivity, recession. So if you can try to wait 20 or 30 minutes after you eat or drink to brush, this includes with vomiting, the same thing. to sensitivity recession. So if you can try to wait 20 or 30 minutes after you eat or drink to brush, this includes with vomiting, the same thing.
Starting point is 02:13:10 So we all wanna brush our teeth after we maybe get sick. Try to just maybe rinse your mouth, maybe with a little baking soda. A lot of this is perfect world, okay? And I get it, but just, I like people to have the information. You said marking, and I meant to ask something earlier, not to return us to the fluoride conversation,
Starting point is 02:13:27 but you said that the person who initially had the idea to include fluoride in treatment of tooth decay noticed that kids' teeth had dark spots on them. Does fluoride cause darkening of the teeth? It can. So I believe it was his pediatric and adult patients. It was just this whole community had these spotted teeth. So that is something called dental fluorosis.
Starting point is 02:13:55 Spots and markings on the teeth can be many different things. One is fluorosis. One could be hypoplastic enamel. I think we should touch on that. So fluorosis can be mild, moderate, or severe. When it gets more severe, that is where it can be dark spotted, orangey brown. Mild fluorosis usually is more brighter white.
Starting point is 02:14:15 You often see it on the incisal tips or on the cusp tips of the molars. It's not a very attractive feature. It's not. And it is a sign that you've had excessive fluoride, you know? And I will say 40% of teenagers now have dental fluorosis. That very likely means they also have some degree of skeletal fluorosis as well.
Starting point is 02:14:37 So for all the challenges that the debate around fluoridization of water has. I am willing to bet a significant amount of my savings that this issue will end up being the linchpin issue. It might seem crazy, right? Like here's the substance that may or may not be safe that we're ingesting for various reasons. And there's a history there
Starting point is 02:15:06 which you beautifully described. But having been in this public facing health education game for a little while now, for the typical person who's like, "'Yeah, whatever, I've been drinking water and I feel fine, or my kid feels fine, or there's nothing I can do about it now. They're 15, maybe they're 10 IQ points down
Starting point is 02:15:22 from where they would be.'" But if you tell people, what I find so they would be. But if you tell people, what I find so interesting about human psychology, if you tell people, did you know that fluoride not only might have some neurodevelopmental impact, it's probably getting into your bones, just like it's getting into your teeth.
Starting point is 02:15:36 But you know that those spots on your teeth, those white spots or dark spots that are really unattractive, that's because of fluoride? Now you've got everybody. Yes, that's because of fluoride. Now you've got everybody. Aesthetics. Aesthetics. And it's either a shame or whatever
Starting point is 02:15:51 that this is the way that people are. But the moment that people realize that something that either is good for them or was intended to be good for them might be bad for their long-term health, you sort of got them hooked, but these long-term correlations are very hard to motivate human behavior.
Starting point is 02:16:08 But those white spots, nobody wants those. Dark spots on the teeth, nobody wants those. And I'd be willing to bet that that becomes one of the key issues. And if people go, oh, listen, it's actually making my teeth uglier. Maybe stronger, but uglier. I bet you this becomes a wedge in the conversation.
Starting point is 02:16:27 That will come from the public, but I will tell you, I have dentists, when I speak as I do about water fluoridation and in fluorosis specifically say, well, it's just aesthetics, at least their teeth are strong. Like they're making the decision for the patient. And I think that's not our right as providers to make that decision for someone, but it's really common.
Starting point is 02:16:50 Fluorosis is very common. I've even seen more recent data saying as high as 60%, but that 40 is kind of the standard number that we go with of teenagers with fluorosis. There is something called hypoplastic enamel. This is something I'm very passionate about. This is under-mineralized enamel, and I believe it's a silent epidemic in children. I see more and more children whose their teeth erupt, and they're mottled and chalky, and
Starting point is 02:17:18 some are so severe they're crumbling. And I've seen a big uptick in this in my 20-year career, and the data is starting to show this as well. And so, unfortunately, so many parents, their kids will get decay. It's really common, and they get shamed and blamed. Like, what are you feeding them? You're not brushing and flossing their teeth. You're neglecting them. Or they're told to stop breastfeeding because that's what's causing the issue.
Starting point is 02:17:41 But it's really that the teeth, the enamel didn't form properly and it's not as acid resistant. It's more fragile, it's more pick-up sticks than the Lincoln logs, okay? And I believe and colleagues globally agree that it's very likely due to all the mineral deficiencies that we're seeing globally and the vitamin D deficiency that we're seeing globally, you know, we're inside all the time, we're not outside, all the junk light that we're getting, the blue light. It can also be from environmental toxins, high fevers, viruses. But it's a real concern and so many children are having to undergo general anesthesia now
Starting point is 02:18:20 to get their teeth fixed. The study I read said about 100 to 150,000 a year for a preventable issue. There's risks to general anesthesia. And this is where I do love to consider a more conservative approach. Can we remineralize these teeth? Are there strategies that we can do to even just kick the can
Starting point is 02:18:40 so the child's older, so they could sit for treatment, so that we're not putting so many children under anesthesia. Because I don't think we have the data for all the long-term potential cumulative effects. And we talked about this earlier. It's not just one exposure, right? It's not just one exposure from an x-ray or one exposure from fluoride or one anesthesia exposure necessarily,
Starting point is 02:19:06 but it's that cumulative effect that we don't have enough data on. Going back to this relationship between the oral microbiome, oral health, and hormones and focusing specifically on female hormones, the menstrual slash ovulatory cycle that occurs each month, as well as perimenopause menopause. About half of our listeners are women. I'm curious, are there certain phases of the menstrual cycle or certain phases of perimenopause, menopause, or prior to it, in which women should pay particular attention to their oral health? Is there a known association with when estrogen is rising or falling that the oral microbiome
Starting point is 02:19:56 tends to be more vulnerable and they perhaps should spend a bit more attention on their oral health? Yes. So we see it both ways, rising and falling. So around puberty, we'll see changes to gum health. So a lot of young girls will have more gingivitis or gum inflammation. And, you know, and certainly if they're on oral contraception, that can change things too.
Starting point is 02:20:19 And they'll go into the dentist and be accused of maybe not brushing or fostering appropriately, but it's really a hormonal issue. So it's important to know that as well as women who are pregnant. Pregnancy gingivitis affects 50 to 70% of women. 50 to 70. It's a lot. Wow. Yeah.
Starting point is 02:20:37 And it usually goes away once you have the baby and you've gotten through some breastfeeding and hormones regulate. But it's important to know that you can also have relaxin, it helps us prepare for childbirth, but it can shift teeth. We have a ligament around our teeth, much like we have ligaments in our pelvis, and that periodontal ligament is impacted by relaxin, so you can see teeth shift and move, and women may sometimes say, my bite is different now, my gum health is different. So it's very important preconception
Starting point is 02:21:07 is certainly during pregnancy to be really on top of your oral hygiene as best as possible and see a dentist regularly. And then perimenopause and menopause, there's a whole slew of issues that happen to women from an oral health perspective with hormonal shifts, decreases in estrogen and progesterone can impact collagen synthesis. So more TM shifts, you know, decreases in estrogen and progesterone can
Starting point is 02:21:25 impact collagen synthesis, so more TMD, more headaches, certainly gum inflammation, dry mouth, burning mouth syndrome, more bad breath, taste changes too. And so what if, it's just so powerful to be able to have these conversations with women rather than just say, well, just use this product, brush and floss more. Maybe we could talk, speaking of it from a hormonal lens, like is hormone replacement therapy appropriate for you or how can we help support you in other ways? Maybe you should see the dentist every two or three months instead of every six months. And also just the mental health component to say, hey, this isn't something you're neglecting.
Starting point is 02:22:04 This is a change your body's going through, and so how can we support you from a dental community? Yeah, thanks for that. More and more I'm getting asked questions on social media and elsewhere about, you know, how is this different for women versus men, and in particular, different phases of the cycle, and perimenopause, menopause,
Starting point is 02:22:24 and essentially the entire lifespan, menopause, and essentially the entire lifespan. So appreciate that. Yeah. I get burning mouth question a lot too from my community. What's burning mouth? Sounds awful. So your mouth feels metallic and it truly feels burning, almost like itchy, I think.
Starting point is 02:22:38 I haven't experienced it, but that's how it's described to me, or kind of like a dry mouth. It can be a sign of zinc deficiency or vitamin B deficiencies, and we can see changes in those with perimenopause and menopause. I think it's important to know the mouth is the gateway into the body, and we can see nutritional deficiencies in the mouth as well. So cracks in the corner of the lips can be a zinc deficiency. It's the same with white striations on the line, on your fingernails, lips can be a zinc deficiency. It's the same with white striations on the line, on your fingernails that can be a zinc deficiency.
Starting point is 02:23:09 B vitamins can be burning mouth or geographic tongue is something people experience. What is geographic tongue caused by? I don't have it. I have a family member who has it. And it's permanent because they're quite far along in their life now and still have it from childhood. We're told in dental school, it maybe has changed,
Starting point is 02:23:31 but it's benign, you know, and just tell patients to avoid citrus and acidic foods. It is cross-linked to latex allergy and psoriasis. So it's an autoimmune issue. It can be a sign of nutritional deficiencies, usually zinc, B or iron. And also it can be a sign of celiac, Crohn's or gut issue.
Starting point is 02:23:56 Again, it's all connected. And so a lot of times when kids see me, I will send them to a functional medicine doctor or a naturopath to just make, to rule that out, you know? And there's genetic dispositions too. As we progress further along in this conversation, these ideas popped to my mind that I'd never thought of before,
Starting point is 02:24:14 like because I don't tend to use them like lip balms, lipstick, I don't use lipstick, I don't use lip balm. I suppose I've put like one of those sunscreens when I went skiing or snowboarding years ago on my, and now I'm wondering like, was that just a terrible idea? I mean, it's good not to burn. Right, people are gonna use, but I suppose specifically like lipsticks,
Starting point is 02:24:39 are they safe for the oral microbiome? Well, I don't think it's getting into your, I mean, hopefully you're not eating it that much, but I mean, we need to be mindful of our products. There's petroleum-based products, a lot of lipsticks, lip balms, they just have nasty ingredients in them. We're learning more and more,
Starting point is 02:24:55 and they're not necessarily as regulated here from a cosmetic standpoint as they might be in the EU. So read your ingredients. But a lot of petroleum-based products will actually cause more dryness, and it has a reverse effect, which is why people get addicted to chapstick, I think. Their lips dry out more.
Starting point is 02:25:15 But when I see chronic dry lips, I'm thinking dehydration, and are you mouth breathing? Because when you mouth breathe, all the tissues dry out. So if a kid comes in with chronically dried lips, I do wonder if they're a mouth breather. Another way to assess if you have a mouth breather on hand is, are you always asking someone in your life to chew with their mouth closed, especially kids? So when we're chewing, we have to breathe.
Starting point is 02:25:40 So you should chew, lips closed, breathe through your nose. But if you can't, because of an obstruction, deviated septum, inflamed nasal turbinates, you'll have that kid, his mouth's always open and they tend not to chew enough. They kind of mash food and swallow it because they're worried about oxygenation. They feel like they're going to choke. These kids tend to get picky eaters because they stay away from meat, carrots, apples, things you have to chew a lot and they stay away from meat, carrots, apples, things you have to chew a lot
Starting point is 02:26:06 and they eat more chicken nuggets, mac and cheese because you can just mash it and swallow it. That can be a sign of oral motor dysfunction in adults and kids. So if you have a hard time chewing with your mouth closed, that's something you can explore and get help with. Should we be able to chew equally on both sides of our mouth?
Starting point is 02:26:23 You should chew equally on both sides of your mouth. So if you're chewing just on one side, not only will you get hypertrophy of the muscles on that side, but it can cause a shift, especially in kids of the way you're growing. But I would want to know why. Why are you chewing that way? Is your occlusion or your bite off? Are you avoiding a tooth because you're in pain? It can be a bad habit. There's ways to retrain, but everything should be symmetrical. So you should kind of chew chew. Your tongue should move the bolus of food to the other side. Chew chew. So if you can't do that, it can be a sign of oral motor dysfunction too.
Starting point is 02:26:56 Maybe your tongue doesn't have good range of motion or mobility. Maybe you have a tongue tie or low tone. So there's a lot that can go into that. And this is where seeing a myofunctional therapist could really help. Maybe you have a tongue tie or low tone. So there's a lot that can go into that. And this is where seeing a myofunctional therapist could really help. You said it, so I'll have to ask. Tongue tie, a few years ago, this was a controversial area.
Starting point is 02:27:14 Tongue tie being the stretch of skin between the bottom of the tongue and the bottom of the, what is it, bottom of the- Floor of the mouth. Floor of the mouth. Thank you. And this idea that in babies it should be cut, to other people say it shouldn't be cut.
Starting point is 02:27:28 And then everyone starts looking at it, or they're like, hi, I mean, I think mine just seems to have naturally torn back or some distance, but you know, what's the deal with tongue tie? Should it be cut? We're going into all the controversial conversations here. I'll take the heat.
Starting point is 02:27:43 So that's called your freenum, okay? So we all have a freenum. It's the band of tissue that attaches our tongue to the floor of the mouth. We also have a labial freenum, and sometimes you have little buckle freenums up here in the vestibule, okay? You have the cheek.
Starting point is 02:28:01 If you put your finger up in your mouth, you'll feel. Oh, yeah, yeah, yeah. You may have them, you may not. When they dried my teeth out for something finger up in your mouth, you'll feel. Oh, yeah. You may have them. You may not. When they dried my teeth out for something, once they pull it back, you see that, yeah. Yeah, you see it stretches. It's like webbed.
Starting point is 02:28:11 Yeah. So the whole thing with this conversation is all about function, okay? So does your tongue and do the oral structures function appropriately, in which case you're good, you know? What's hard is something to be mindful of. You can't diagnose anyone from a photo on social media. So I see a lot of parent blogs who are saying, my child has a tongue tie, my child has a lip tie.
Starting point is 02:28:38 You can't tell. We have to look at function. So is it impairing or impacting breastfeeding? Can the tongue not lift appropriately? It's all about lifting, elevating, and lateralizing. So many think tongue-tight impacts you sticking your tongue out. We don't care as much about that.
Starting point is 02:28:56 What grows the face and the palate in utero and then beyond is that tongue lifting, elevating, and spreading that palate almost like an expander, like an orthodontic expander. And so if it can't lift, that's the first sign. And that means it can pull in the breast tissue and breastfeed appropriately. Babies might have a lot of reflux. Women will have pain.
Starting point is 02:29:20 Okay? So that's one of the first things we look at. But then as children get older, we look, well, is there a tongue tie that is potentially leading to mouth breathing? So when your lips are closed and you're breathing through your nose, your tongue should be up at the palate and it should have enough tone to stay there, ideally while we sleep too. But if your tongue is tethered, it can't lift up, your tongue's going to lay low and you're going to have more of the Napoleon Dynamite look, okay? So that open mouth forward head posture. That's just because the tongue can't
Starting point is 02:29:54 lift. Many times when people have tongue tied, their palates are narrow too because in utero, the tongue wasn't up to grow the face optimally. And this runs genetically in families as well, the predisposition. So then the next thing we look at is speech, you know, and is it impacting speech or is it impacting chewing and swallowing? So if all of those things are fine, if it looks like there's a tongue tie, but you're thriving, you're doing great, assuming you're not compensating and using other muscles and now having other downstream effects like shoulder pain, headaches, postural issues, you're great. But if a child is having issues and you've gone through the right screening and had the
Starting point is 02:30:39 risk benefit discussion with the parents, I do think a phrenectomy is indicated, and I myself have had one and it benefited me a lot. My issues were neck strain and a lot of shoulder tension that really, there's a lot of fascial tissue that's impacted with a tongue tie or can be, and so it helped me a tremendous amount. But nothing's one size fits all and we're all different. So this is where you do wanna work with someone with additional training to see if
Starting point is 02:31:09 you have a tongue tie, how are they assessing that and then is it impairing function and then do you actually need a procedure done. Sometimes just working with a myofunctional therapist or different body workers, a chiropractor, a craniosacral therapist, an osteopath can be enough to create balance again. So it's not always a surgical intervention. In your case, was it a general anesthesia or a local anesthesia? I had my tonsils out also very recently, just a few years ago, because I had chronic tonsillitis.
Starting point is 02:31:42 And so I knew I had a posterior tongue tie, and I just told the surgeons, go ahead and do it. I'm already getting my tonsils out. Sure, you're already in there. Yeah, already in there. But for most people, it would be a general anesthesia? Usually no. Usually it is local.
Starting point is 02:31:59 It's really not bad, especially they're using lasers now for their procedure. It's pretty straightforward. Yeah. That can cauterize as you make the cut. Exactly. You do want to generally suture and you want to make sure you're working with a myofunctional therapist before and after for optimal outcomes. It's like, think about if I went in for a knee replacement, I wouldn't just walk into
Starting point is 02:32:18 the operating room, here's my knee. Usually there's physical therapy before and after to make sure you're optimized. And so it's the same with a tongue release. Peptides and red light therapy. Now we're in the specialized next sort of cutting edge of health and self-directed health or self-directed slash working with a professional like yourself, oral health care. So can red light therapy, like shining red light and near infrared light, so long wavelength
Starting point is 02:32:54 light into the mouth, provide any benefits for a person that doesn't have any other issues, like they just want to maximize their oral health? Is that something that can be helpful? What else is it potentially helpful for? Yeah, it certainly couldn't hurt. I haven't seen any solid data on that, but it would reduce inflammation, improve blood flow. So I'm not opposed to it.
Starting point is 02:33:18 It's wonderful post-surgery. So if you have wisdom teeth out or periodontal surgery, a lot of dentists and specialists are using red light therapy extra orally or intra orally to help expedite healing, collagen synthesis, etc. Peptides are newer and exosomes as well that are being used particularly in root canal therapies and maybe cavitation surgeries and things. Again, just to help with inflammation, healing, collagen synthesis. It's pretty cool. It's very cutting edge and it's very new and there's very few out there doing it right now. There's a couple in LA that I know are, so I can
Starting point is 02:33:58 share names. But the idea is to regenerate tissues, specifically with peptides. It can, when put down in the pulpal chamber, potentially can help build up the dentin within the tooth and maybe help increase vascularization, get some more vitality back to the tooth too. So it's pretty cool. Yeah. All right. So we'll stand by on that. Yeah, stand by. Should we be concerned about metal fillings?
Starting point is 02:34:23 Whatever, I don't know what material they use for the other fillings. And sometimes they'll use quote unquote sealants, like they'll see a pit, they'll put some sealant in there. And retainers are made from plastic, now everyone's worried about plastic. So what gives? So the best dentistry is no dentistry. I will always say that. So that's why we always want to take a preventative lens as best we can, but that's not the reality since 90% of us have suffered from some sort
Starting point is 02:34:49 of dental disease in our life. So mercury fillings, this can get controversial. I think the first thing to do, I don't love mercury amalgam fillings, and they were recently banned in Europe. I think if you're getting a new filling, I would try not to have mercury placed. That would be my recommendation. Try to use a composite, ideally a ceramic-based biomimetic material. But if you have existing mercury fillings, amalgam fillings, and you're concerned, the
Starting point is 02:35:22 first thing to do is get a test. Get a blood test to see what are your mercury levels. If they're within normal, I wouldn't worry too much. If you have mercury toxicity or mercury through the roof, then you probably should have that conversation with your dental team and your medical team to see, could this be coming from my fillings? And certainly if a filling is breaking, damaged, it needs to be replaced maybe considering not doing an amalgam metal filling.
Starting point is 02:35:51 So that's kind of my stance on that. Composite fillings, you know, they are plastics essentially. Most are BPA-free, but that is a bit of a marketing idea. You know, there's still other plasticizers in there, BizGMA, et cetera. So I do really like ceramic-based materials if you can find them. Nothing is perfect.
Starting point is 02:36:13 You know, this is the best available that we have. Regarding retainers, I get this question a lot too. Acrylic retainers, those are the pink retainers. What's interesting about those, methyl methacrylate can have gluten in it, so if you are celiac, there have been case reports of teens especially who they keep having GI distress or rashes, because celiac often can come out in the skin,
Starting point is 02:36:42 and they can't figure out why, and it ties back to their retainer. So just be aware of that. And then people will ask all about Invisalign and again, nothing's perfect. Usually most of these retainers and things you're only wearing for a short period as you're trying to correct your airway issue. So lesser of two evils. I mean, I'm a big airway advocate.
Starting point is 02:37:07 I want people breathing optimally. That is the most important thing for your health, in my opinion, is optimized oxygenation and breathing and rest and recovery. So I am an advocate for expansion in some of these materials and products for short durations if necessary.
Starting point is 02:37:26 So, we can't take all the risk out of everything, right? And this is why the host, making sure your immune response is optimized, your detox pathways are open, your phase two liver detox is optimized. That's ideal. So, yeah. Yeah. Cruciferous vegetables, sulfuraphane, supplementation maybe. Bitter, dandelion. The same things that were recommended in the microplastics episode that I did that other
Starting point is 02:37:52 people have touched on. So things like sauna, sulfurophane. Yes, binders. Cruciferous vegetable intake should help bind to some of the microplastics that surely we are ingesting. Everyone has them. So you just try to minimize your exposure. And then sealants, I am an advocate of sealants.
Starting point is 02:38:10 They really do reduce cavity risk. They're usually put on the molars in the grooves and the fissures of the back teeth. But again, I use spectrometry to make sure I'm not sealing in bacteria so it's an image that shows me if there's like caries or cavity there. I'm using ozone to make sure I'm killing the bacteria. Sometimes I'll use my laser, which helps disinfect too to open the groove up. And then I'm using ceramic-based materials too.
Starting point is 02:38:42 So I think it depends on your risk as well. If you're low risk, you're not eating a lot of these ultra-processed foods, you're probably materials too. So I think it depends on your risk as well. If you're low risk, you're not eating a lot of these ultra processed foods, you're probably okay. But a lot of kids, we have control over our children's diets only to a certain point. And then they go off to middle school and start eating the Takis and the Doritos and they make maybe some bad choices. And so if you want their teeth as protected as possible,
Starting point is 02:39:05 I'd suggest sealants. A somewhat unpleasant topic, but something that I've heard repeatedly, and I don't know if it's true, is that dentists more than people in any other profession commit suicide at very high rates. And then there's this very dark joke that people make. Well, you know, their hands are always in other people's mouths
Starting point is 02:39:29 so they don't have anyone to talk to, you know, like, and then I always think, well, the logic's wrong there. They actually could talk as much as they want. It's the patients that can't talk. So, you know, setting aside that kind of like, you know, gallows humor, which I don't, it's not my style of humor. Do dentists kill themselves more
Starting point is 02:39:46 than people in other professions? Yeah, thank you for bringing this up. I think it's important to talk about. Dentists do have a really high rate of depression, anxiety, and yes, suicide too. I always heard this too even before I became a dentist and it's a really hard profession. And so we tend to be the brunt of the joke,
Starting point is 02:40:06 we're in the song, there's songs like, I'm afraid of Dentist in the Dark by Vance Joy and like Steve Martin playing the eccentric dentist in multiple different movies I think. Little Shop of Horrors. Little Shop of Horrors, Horrible Bosses, there's like a crazy dentist, there's always like horror movies have dentists.
Starting point is 02:40:26 I mean, we are the brunt of the joke a little bit. And so that's hard. And unfortunately, there are just so many negative childhood experiences at the dentist. And this is partly why I went into pediatrics is that I was an adult dentist for many years. I felt very dissatisfied with my career because I just felt like I wasn't making a difference. You know, dental disease is so prevalent. And unless we're talking about it from this root cause lens,
Starting point is 02:40:55 we're not going to move the needle. But it's very hard when you get in the system to get out of it. You know, the way our appointment times are set up and the overhead is crazy and the student debt now and the pressures and the things with dentists is we are the clinicians but we're also kind of the CEOs of our businesses. Like many of us have private practices. So you're wearing two hats, so when you're done with treatment all day and seeing patients all day, then you're sitting in front of the computer and you have people to help you, but you're trying to manage the business.
Starting point is 02:41:27 And we didn't go into school for that, you know, looking at spreadsheets, HR issues, et cetera. And many of us are in solo practices, so it can be very lonely. But also, we tend to be more type A personalities, perfectionists, and dentistry is hard. There's a lot of unknowns, there's a lot of variables. You know, I can put a filling in your mouth, but I can't guarantee that you're going to brush, floss, follow my rules, not eat ultra-processed foods. You're breathing through your nose, what's your microbiome like? So then you're doing all of these things that I've instructed you not to do, and
Starting point is 02:42:03 then you come back because the filling fails. and we're the ones to blame for that. And don't get me wrong, there's all variations of providers out there, and there's people doing excellent work and people doing not so excellent work. But I do think it's important for everyone to know that many dentists are having a hard time with work, especially post-COVID, I would say. There's a lot of pressures. Dental insurance is very challenging. It's not truly insurance, like medical insurance.
Starting point is 02:42:34 It's really a benefit package. And so you tend to only get a thousand or $1,200 a year, and then everything else is out of pocket. And so people kind of look at us like that's kind of a scam, you know, like it's so expensive. But what they don't realize is many of these dental supply companies, they have essentially monopolies on us. Like our equipment is outrageously expensive. And prices keep going up and up and up.
Starting point is 02:43:01 But what isn't changing are insurance reimbursements. Okay, so where does that delta come in? And usually it's coming out of the dentist's pocket too. So it's why corporate dentistry is taking over, in a lot of ways, kind of what happened in medicine. But I would just say be kind to your dentist. Just recently, this is very timely, but I don't know where this came from. Maybe it was like a TikTok thing, but there were letters being mailed. Specifically, I saw in the Pacific Northwest, to Oregon and Portland, that dentists were receiving these hate letters
Starting point is 02:43:33 saying dentists are scumbags and they should all kill themselves. So I think it's important for people to know what we kind of deal with behind the scenes, you know, and to just be kind to your dentist. And I would say if someone doesn't resonate with you, if their personality doesn't resonate with you, just go find a different dentist.
Starting point is 02:43:55 And I will, I do want to understand there is a lot of post-traumatic stress disorder from patients who truly fear the dentist. It's usually from experiences in childhood. And that's what I wanted to change too. I just said it doesn't have to be this way. We can make dentistry a very positive place, a safe place so that children go into adults without dental disease,
Starting point is 02:44:14 but also that find the dentist to be a safe, comfortable place to go. So I mean, some people, if you're really that fearful, maybe considering therapy or some sort of anxiolytic, like do you need something to help you feel calmer at the dentist? But I encourage everyone to go to the dentist, don't avoid the dentist, but also trying to understand it.
Starting point is 02:44:36 It is a challenging profession, it really is. And there's a lot of unknowns and there are some mental health challenges out there too. Well, thank you for being an incredible ambassador for dentistry and no small part that comes from your like obvious kindness and goodness and also the rigor with which you approach it. So, the two are certainly not incompatible, you're proof of that. Thank you. I wonder if now would be a good time for us
Starting point is 02:45:06 to just sort of summarize the top 10 or top 12 things. There are a bunch of don'ts. Maybe we can leave those out. Like avoid sugary, starchy, flowery foods that get stuck between teeth, that kind of thing. But maybe I'll fire off a few and you can tell me what I'm missing. Be a nose breather, not a mouth breather.
Starting point is 02:45:28 Unless you're eating or speaking, keep your mouth shut basically, right? Absolutely. Or you're exercising really hard and you need to suck for some air or you're scuba diving and you would drown otherwise. Eat non-processed, minimally processed foods. We're hearing that over and over again these days.
Starting point is 02:45:45 Brush twice a day, floss twice a day, water pick if you can. Yeah, that's loading a lot onto people. I would say floss at least once a day. Flossing twice a day is extra credit. Great. Yeah, because a lot of people don't floss. So we want to start out reasonable.
Starting point is 02:46:05 Before sleep. Yes, ideally. So it's brush, then floss. Floss, then brush. Floss, then brush. But however you can do it. No, no, no, I didn't get it wrong on purpose. I also like tongue scraping.
Starting point is 02:46:19 We forgot to talk about tongue scraping. Yeah, so I want to add in these things. So maybe oil pull three times a week, put some olive oil, coconut oil in there, swish it around, practice your nasal breathing while you're doing it. That's right. Spit it out, but not in the sink. Not in the sink. And why just a few times a week?
Starting point is 02:46:37 I don't know if I was clear on that. It's because coconut oil is antimicrobial. So I'm errant on the side of caution because it will target more anaerobic pathological bacteria, but less is more. We don't want to disrupt the oral microbiome too much. Just a couple times a week, you don't need to do it daily. Great. Soft toothbrush, be gentle, avoid alcohol-containing mouth washes for all sorts of reasons.
Starting point is 02:47:04 Pay attention to the fluoride debate. Yes. Consider hydroxyapatite if you're concerned. Great, I love these hydroxyapatite toothpastes. Yours and Gator Dentist's one. Love them, I don't get paid a dime for it. I pay my own money for them, I really love them. My teeth are so much healthier now.
Starting point is 02:47:23 I just like them too. I like that I can, they taste good. I don't actually rinse afterwards. We didn't talk about that, but ideally you don't rinse after you brush. Correct. So think about if you were a big advocate for sunscreen or a lotion, you put it on,
Starting point is 02:47:39 you immediately jump in the shower. You're washing it all off. So it's the same with your toothpaste. There is a duration of action that it takes for maximum efficacy. So if you're brushing for two minutes and spit and rinse, all that goodness is getting rinsed down the drain. So it really should, you can still spit, people get confused by this. You can still spit, but try not to vigorously rinse everything off. You do want to try to, try to sit on the teeth and in your saliva a little bit. Avoid nicotine.
Starting point is 02:48:08 I like alcohol. And alcohol. Hydrate well. Yes. Electrolytes. Keep your electrolytes, keep your saliva abundant. Yes. Especially for older people.
Starting point is 02:48:19 Yes. Yeah. The nasal breathing during sleep, we can double click on that one because that's how to get your sleep right. Absolutely, because I just check so many boxes. I'd say optimize minerals and fat soluble vitamins. This is kind of Weston Price stuff.
Starting point is 02:48:36 I'm trying to think here if there's anything I missed. Well, we could say tongue scraping. Tongue scraping, excuse me. I do like tongue scraping. So again, Ayurvedic, Chinese medicine, Well, we could say tongue scraping. Tongue scraping, excuse me. So I do like tongue scraping. So again, Ayurvedic, Chinese medicine will look at the tongue from a health standpoint. If you have a white coating on your tongue, that's a sign of dysbiosis. You could have candida.
Starting point is 02:48:57 This is important to touch upon. Strep mutans gets blamed for cavities so much with kids especially, but with children, we really need to be focusing on fungus too. So candida is really prevalent in early decay in children. No one's screaming for this or treating it. Candida loves sugar, you know, and this is also with diabetics, we're seeing a bidirectional relationship with gum disease, periodontal disease, and insulin resistance, and blood sugar imbalances too.
Starting point is 02:49:26 So tongue scraping, and it will do a better job than your toothbrush. People always ask because it is removing the biofilm as the toothbrush is kind of moving it around. So it's taking off that film of bacteria. I know it's kind of gross, but they tend to be anaerobic. And that can help with nitric oxide production too, because the good bacteria on the tongue tend to live down more in the crypts. So you don't want to scrape too hard, but just get that film off.
Starting point is 02:49:57 You'll also notice improvement in your taste perception too, because you're getting food remnants and things off as well. We want that. Yeah. Oh, I love it. Once you start tongue scraping, you usually, most everyone's a big advocate for it. Thank you so much for this really extensive and exceptionally clear voyage through oral health.
Starting point is 02:50:17 I am sure that people are gonna take away many, many things that are actionable. And I really appreciate that you've been such a strong advocate for pointing out that oral health is not just about teeth, it's not just about breath, it's about that, but it's also about your whole digestive tract and about brain health and about heart health.
Starting point is 02:50:38 And we have a lot of control over this particular aspect of our body, as opposed to like heart health, which we have to get to indirectly unless we're a heart, as opposed to like heart health, which we have to get to indirectly unless we're a heart surgeon. Yes. Or gut health, which we have to get to indirectly unless we're a gastroenterologist, right? Exactly.
Starting point is 02:50:52 What other biofilms do you have access to? I mean, it really is a window into the body. So if you have gum disease or cavities, that is a sign of a metabolic imbalance in your body. So not to make you panic, but I just want people to take it seriously, that it is a sign of a metabolic imbalance in your body. So not to make you panic, but I just want people to take it seriously, that it is a window into other things that could be happening deeper within the system.
Starting point is 02:51:13 Well, I absolutely love the work that you're doing. I couldn't think of a better person to bring on here to educate us all. And like I said, you've given us so many valuable tools and we will provide links to all the incredible resources that you continue to put out into the world. So thank you for doing that. Thank you for coming here.
Starting point is 02:51:29 Thanks for, it's clear that this is a labor of love for you. It's not just about like cleaning teeth or something. So yeah, that you're, people probably can't see, well, certainly if they're listening, they can't see the incredible extensive notes that Dr. Whitman brought with her and her incredible handwriting. Goodness gracious, what beautiful handwriting.
Starting point is 02:51:50 Thank you. So I could read it later. Not all doctors have bad handwriting. No, they notoriously have bad handwriting, but yours is, you certainly offset whatever failures of handwriting the other physicians have. So- This was really fun. Thank you so much.
Starting point is 02:52:03 Thanks. Well, we'll do it again. And I'm really grateful for you This was really fun. Thank you so much. Thanks. Well, we'll do it again. Appreciate it. And I'm really grateful for you coming on here today. Thank you. Yes, thank you. we discussed, please see the show note captions. If you're learning from and or enjoying this podcast, please subscribe to our YouTube channel. That's a terrific zero cost way to support us. In addition, please follow the podcast by clicking the follow button on both Spotify and Apple.
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Starting point is 02:52:56 I do read all the comments. For those of you that haven't heard, I have a new book coming out. It's my very first book. It's entitled, Protocols, an Oper manual for the human body. This is a book that I've been working on for more than five years,
Starting point is 02:53:07 and that's based on more than 30 years of research and experience. And it covers protocols for everything from sleep, to exercise, to stress control, protocols related to focus and motivation. And of course, I provide the scientific substantiation for the protocols that are included. The book is now available by pre-iation for the protocols that are included.
Starting point is 02:53:25 The book is now available by presale at protocolsbook.com. There you can find links to various vendors. You can pick the one that you like best. Again, the book is called Protocols, an operating manual for the human body. And if you're not already following me on social media, I am Huberman Lab on all social media platforms. So that's Instagram, X, threads, Facebook, and LinkedIn.
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Starting point is 02:54:01 to our Neural Network Newsletter, the Neural Network Newsletter is a zero cost monthly newsletter that includes podcast summaries, as well as what we call protocols in the form of one to three page PDFs that cover everything from how to optimize your sleep, how to optimize dopamine, deliberate cold exposure.
Starting point is 02:54:16 We have a foundational fitness protocol that covers cardiovascular training and resistance training. All of that is available completely zero cost. You simply go to hubermanlab.com, go to the menu tab in the top right corner, scroll down to newsletter and enter your email. And I should emphasize that we do not share your email with anybody.
Starting point is 02:54:33 Thank you once again for joining me for today's discussion with Dr. Stacy Whitman. And last but certainly not least, thank you for your interest in science.

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