Huberman Lab - How to Learn Faster by Using Failures, Movement & Balance

Episode Date: February 15, 2021

In this episode, I discuss how we can use specific types of behavior to change our brain, both for sake of learning the movements themselves and for allowing us to learn non-movement-based information... as well. I describe the key role that errors play in triggering our brains to change and how the vestibular (balance) system can activate and amplify neuroplasticity. As always, I cover science and science-based practical tools. Thank you in advance for your questions and for your interest in science! For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Introduction (00:00:29) Sponsors: AG1, LMNT (00:06:20) Nerves and Muscles (00:12:00) Exercise alone won’t change your brain (00:12:58) Behavior will change your brain (00:13:30) Remembering the wrong things (00:15:00) Behavior as the gate to plasticity (00:15:45) Types of Plasticity (00:17:32) Errors Not Flow Trigger Plasticity (00:21:30) Mechanisms of Plasticity (00:22:30) What to learn when you are young (00:23:50) Alignment of your brain maps: neuron sandwiches 00:26:00: Wearing Prisms On Your Face (00:29:10) The KEY Trigger Plasticity (00:32:20) Frustration Is the Feeling to Follow (Further into Learning) (00:33:10) Incremental Learning (00:35:30) Huberman Free Throws (00:38:50) Failure Specificity Triggers Specific Plastic Changes (00:40:20) Triggering Rapid, Massive Plasticity Made Possible (00:43:25) Addiction (00:45:25) An Example of Ultradian-Incremental Learning 00:49:42: Bad Events (00:51:55) Surprise! (00:52:00) Making Dopamine Work For You (Not The Other Way Around) (00:53:20) HOW to release dopamine (00:55:00) (Mental) Performance Enhancing Drugs (00:56:00) Timing Your Learning (00:57:36) (Chem)Trails of Neuroplasticity (00:58:57) The Three Key Levers To Accelerate Plasticity (00:59:15) Limbic Friction: Finding Clear, Calm and Focused (01:04:25) The First Question To Ask Yourself Before Learning (01:05:00) Balance (01:07:45) Cerebellum (01:10:00) Flow States Are Not The Path To Learning (01:11:18) Novelty and Instability Are Key (01:14:55) How to Arrive At Learning (01:15:45) The Other Reason Kids Learn Faster Than Adults (01:19:25) Learning French and Other Things Faster (01:22:00) Yoga versus Science (01:32:00) Closing Remarks Title Card Photo Credit: Mike Blabac Disclaimer

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Starting point is 00:00:00 Welcome to the Huberman Lab podcast where we discuss science and science-based tools for everyday life. My name is Andrew Huberman and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine. This podcast is separate from my teaching and research roles at Stanford. It is, however, part of my desire and effort to bring you zero cost to consumer information about science and science-related tools. In keeping with that theme, I'd like to thank the sponsors of today's podcast. Our first sponsor is Athletic Greens. Athletic Greens is an all-in-one vitamin mineral probiotic drink. I've been taking Athletic Greens since 2012, so I'm delighted that they're sponsoring the podcast. The reason I started taking Athletic Greens and the reason I still
Starting point is 00:00:43 take Athletic Greens once or twice a day is that it helps me cover all of my basic nutritional needs. It makes up for any deficiencies that I might have. In addition, it has probiotics, which are vital for microbiome health. I've done a couple of episodes now on the so-called gut microbiome and the ways in which the microbiome interacts with your immune system, with your brain to regulate mood, and essentially with every biological system relevant to health throughout your brain and body. With athletic greens, I get the vitamins I need, the minerals I need, and the probiotics
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Starting point is 00:01:33 Many of us are still deficient in vitamin D3. And K2 is also important because it regulates things like cardiovascular function, calcium in the body, and so on. Again, go to athleticgreens.com slash uberman to claim the special offer of the 5 free travel packs and the year supply of vitamin D3 K2. Today's episode is also brought to us by Element. Element is an electrolyte drink that has everything you need and nothing you don't. That means the exact ratios of electrolytes are an element and those are sodium, magnesium
Starting point is 00:02:01 and potassium, but it has no sugar. I've talked many times before on this podcast about the key role of hydration and electrolytes for nerve cell function, neuron function, as well as the function of all the cells and all the tissues and organ systems of the body. If we have sodium, magnesium, and potassium present in the proper ratios, all of those cells function properly and all our bodily systems can be optimized. If the electrolytes are not present and if hydration is low, we simply can't think as well as we would otherwise. Our mood is off, hormone systems go off, our ability to get into physical action, to engage
Starting point is 00:02:37 an endurance and strength, and all sorts of other things is diminished. So with element, you can make sure that you're staying on top of your hydration and that you're getting the proper ratios of electrolytes. If you'd like to try element, you can go to drinkelement. That's L-M-N-T dot com slash huberman, and you'll get a free element sample pack with your purchase. They're all delicious. So again, if you want to try element, you can go to element element dot com slash huberman.
Starting point is 00:03:01 Today we're going to talk about how to change your nervous system for the better. As you recall, your nervous system includes your brain and your spinal cord, but also all the connections that your brain and spinal cord make with the organs of your body, and all the connections that the organs of your body make with your brain and spinal cord. This thing that we call the nervous system is responsible for everything we know, all our behavior, all our emotions, everything we feel about ourselves and the outside world, everything we think and believe it's really at the center of our entire experience of life and who we are.
Starting point is 00:03:36 Fortunately, in humans, unlike in other species, we can change our nervous system by taking some very specific and deliberate actions. And today we're really going to focus on the actions. The motor commands and the aspects of movement and balance that allow us to change our nervous system. It turns out that movement and balance actually provide windows or portals into our ability to change our nervous system the way we want even if those changes are not about learning new movements or learning how to
Starting point is 00:04:10 balance and soon you'll understand why. So today we're going to talk a lot about the basic science of neuroplasticity. I promise to not use excessive nomenclature there'll be a little bit but I'll try and make it as clear as possible. And we're also going to talk a lot about protocols and tools that the scientific literature points to and supports for changing our nervous system, again, not just for sake of learning new motor movements or how to balance better, but for how to feel differently about particular experiences, both past, present, and future, as well as how to learn faster. We're not going to discuss hacks or word I love. We're not going to discuss gimmicks.
Starting point is 00:04:52 We're going to discuss mechanism and scientific data and the tools that those mechanisms and scientific data point to so that you can tailor your practices around learning to your specific needs and goals. So, let's begin by just examining the big picture question, which is, does the brain control behavior? And my hope is that everyone is immediately thinking, yes, the brain and nervous system, we really should say, because the brain is just one component of the nervous system, controls our behavior. How does it do that?
Starting point is 00:05:26 Well, there are a couple different levels that it does that. First of all, if we're talking about movement, behavior generally means movement, if we're talking about movement, we have two categories of neurons that are very important to think about in the context of neural plasticity. First of all, we have what are called lower motor neurons. These are motor neurons that live in our spinal cord. If for the aficionados out there, for those of you that might be head to medical school,
Starting point is 00:05:55 or just wanna learn more about the anatomy, they live in the ventral horn of the spinal cord, but that doesn't matter. If you don't wanna know that, just know that you have these things called lower motor neurons. These are neurons that are in the spinal cord, but they extend a wire that we call an axon, If you don't want to know that, just know that you have these things called lower motor neurons. These are neurons that are in the spinal cord, but they extend a wire that we call an ax
Starting point is 00:06:09 on out into the peripheral nervous system, into the body, and those neurons connect with muscle. They send electrical potentials out there that allow our muscles to twitch and to contract. As a little point of fact, actually, we don't have muscle memory. There's no such thing as muscle memory. Muscles are dumb. They don't know anything. They don't have a history.
Starting point is 00:06:34 They don't have a memory. They don't know anything. It is the neurons that control those muscles and their firing patterns in which all the information for motor patterns are stored. So your ability to walk is not muscle memory, it's neural memory. Now, the lower motor neurons, while smarter than the muscle, so to speak, are not the most brilliant of the motor neurons. They are generally involved in doing what they are told, and they are told what to do from two sources.
Starting point is 00:07:07 We have circuits in our brain stem, so this would be kind of around your neck deep in the brain, that are called central pattern generators. These are sometimes called CPGs. Central pattern generators are what allow us to generate repetitive patterns of movement. So inhaling and exhaling and exhaling, subconsciously is controlled by a central pattern generator.
Starting point is 00:07:28 That just means a collection of neurons. If you really wanna know, they're called the Pre-Bot Singer Neurons, discovered by Jack Feldman and colleagues at UCLA. These neurons in the brain stem send information down the phrenic nerve and control the diaphragm. So then it goes inhale, exhale, inhale, exhale. And you don't have to think about that. You could think about it and you could change the durations of inhales and exhales. and control the diaphragm, so it goes inhale, exhale, inhale, exhale.
Starting point is 00:07:45 And you don't have to think about that. You could think about it and you could change the durations of inhales and exhales and change that up. But the motor neurons that control that are just responding to what the brain is telling it to do. The other central pattern generators include things like walking, the right limb, left limb, right limb, left limb pattern that we normally associate with walking was learned during childhood and the central pattern generators, sometimes called CPGs, tell our lower, lower motor neurons
Starting point is 00:08:16 fire. Now you fire, now you fire. So they are literally saying right, left, right, left. They are the marching orders from the brain stem to the lower motor neurons. So these lower motor neurons do what they are told. They are obedient little soldiers and they do what they are told. And their job is to make the muscles contract at specific times. Okay.
Starting point is 00:08:37 That's all simple. But then there are the upper motor neurons. The upper motor neurons actually reside in our motor cortex, way up on top of the brain, and they are involved in sending signals for deliberate action. Okay, so they send signals to the lower motor neurons, which are the effectors, the ones that actually control the muscles, but the upper motor neurons are the ones that send very specific signals. For instance, the signals that would allow you to make a cup of coffee in the morning or to deliberately engage in any kind of behavior. Now, you can probably make a cup of coffee in the morning without having to think about it too much.
Starting point is 00:09:14 It's almost reflexive for you now, which means that a lot of the information about how to perform that particular movement has been passed off to circuitry that's now more less in the brain stem and below the motor cortex. Now, why am I giving you all this detail? Well, if you want to change motor patterns, you have to know where in the circuitry changes are possible and you have ought to know where the changes are most likely to occur. You also need to know how do you signal to the brain that a nervous system that a change is necessary. So let's just pause there, return to the initial question
Starting point is 00:09:54 that we started with, which is does the brain control behavior and the answer is yes, and now you know how. It's upper motor neurons, lower motor neurons, you've got these things called central pattern generators and some connection with the muscles. So there you go. You just got basically what was the equivalent of the introduction to a college lecture on motor control in the nervous system,
Starting point is 00:10:14 but the point today is all about plasticity. How can that be leveraged in order to open up this magical thing that we call plasticity, in order to access changes this magical thing that we call plasticity in order to access changes to our emotional experience or to our belief system or to our ability to remember and use specific kinds of information for say math or language, etc. Well, what I'm not going to tell you is that you need to go running or you need to go biking or that simply going through motor patterns is going to open up plasticity or you need to go biking or that simply going through motor patterns
Starting point is 00:10:46 is going to open up plasticity because I hate to tell you this but as beneficial as exercise is, it does not open plasticity unless you do certain things and I will tell you exactly what those certain things are today. To be clear, I think exercise is wonderful and healthy, can improve cardiovascular function, maintain strength, bone density, all that good stuff, but just working out or doing your exercise of various kinds will not change your nervous system. It will maintain it and it can certainly improve other health metrics, but it is not going to open up the window for plasticity.
Starting point is 00:11:22 The question we need to ask is can behavior change the brain? We already agreed that the brain can change behavior, but can behavior change the brain? And the answer is yes, provided that behavior is different enough in specific ways from the behaviors that you already know how to perform. Let me repeat that. Can behavior change the brain? And the answer is yes. Provided that behavior is different enough from the sorts of behaviors that you already know how to perform.
Starting point is 00:11:54 And I should have added the word well. Because you can't obviously perform a behavior that you don't know how to perform because you don't know how to do it yet. But there's a key element to accessing neural plasticity that frankly, I don't see out there in the general discussion about neural plasticity. In the general discussion about neural plasticity
Starting point is 00:12:14 and about learning, I hear all these gimmicks about using different ways to remember lots of people's names and arranging things into their first letters and mnemonics and all this kind of stuff, which frankly to me feels really gimmicky. And I think that if you look at super learners, they tend to be people that have a process of, say, extreme memory. But people who have extreme memory generally, the literature shows us, are pretty poor
Starting point is 00:12:39 at other things. So I don't think most of us are interested in walking around knowing how to remember everything. In fact, there are some interesting studies looking at humans who over-remember and they suffer tremendously because they remember all sorts of things like the number at the top of the receipt at the bodega that they bought a Coca-Cola 10 years ago. This is useless information for most people. They don't do well in life, really. So the goal isn't to remember everything. The goal is to be selective about your brain changes.
Starting point is 00:13:10 And when we talk about brain changes, I want to highlight adaptive changes. There's a whole category of things that we're going to discuss when we talk about traumatic brain injury and dementia, a topic for a future episode, about all the things that happen when you have damaged your nervous system or you're missing neurons.
Starting point is 00:13:27 But today, I really want to talk about something that I think is very near and dear to many of your hearts, which is what are the behaviors that you can engage in to access neuroplasticity so that then you can apply that plasticity to the specific things that you want to learn or unlearn. This is very important because I don't want people to get the impression that we're really talking about learning a bunch of motor movements. You may be an athlete, you might not be an athlete, you might want to learn how to dance, you might not.
Starting point is 00:13:57 You might want to learn how to dance and get better at remembering and learning languages, for instance, or at unlearning some difficult emotional experience, meaning you want to remove the emotional load from a particular memory of an experience. What we're talking about today is using behavior as a gate to enter states of mind and body that allow you to access plasticity. So let's talk about the different kinds of plasticity that are available to us. Because those will point directly towards the type of protocols that we should engage in to change ourselves for the better, this so-called adaptive plasticity.
Starting point is 00:14:37 There is something called representational plasticity. Representational plasticity is just your internal representation of the outside world. So you have a map of auditory space, believe it or not, meaning you have neurons. They respond when something over on my right happens, like I'm snapping my fingers over to my right. I can't snap as well on my left, which is the whole thing into itself. Yeah, week over there on the left side. But when I do that, there are different neurons respond to those. We have a map of visual space.
Starting point is 00:15:06 Certain neurons are seeing things in certain portions of visual space and not others. We have a map of motor space, meaning when we move our limbs in particular directions, we know when though where those limbs are, because even if we can't see them, we have what's called proprioceptive feedback. So we have knowledge about where our limbs are. In fact, people that lack certain neurons that for for proprioceptive feedback, they are very poor at controlling their motor behavior. They get injured a lot. It's actually a terrible situation. So we've got all these representations inside and we have maps of our motor commands.
Starting point is 00:15:43 We know that for instance, if I want to reach out and grab the pen in front of me, that I need to generate a certain amount of force. So I rarely overshoot. I rarely miss the pen. Okay? So our maps of the motor world and our maps of the sensory world are merged. The way to create plasticity is to create mismatches
Starting point is 00:16:08 or errors in how we perform things. And this I think is an amazing and important feature of neuroplasticity that is highly underappreciated. The way to create plasticity is to send signals to the brain that something is wrong, something is different and something isn't being achieved. And I think this will completely reframe the way that most people think about plasticity. Most of us think about plasticity as, okay, we're going to get into this optimal learning state
Starting point is 00:16:34 or flow, and then suddenly we're going to be able to do all the things that we wish that we could do. Well, I hate to break it to you, but flow is an expression of what we already know how to do. It is not a state for learning. And I'm willing to go to bat with any of the flow Anistas out there that want to challenge me on that one. Flow is an expression of nervous system capabilities that are already embedded in us.
Starting point is 00:16:58 Errors. And making errors out of sync with what we would like to do is how our nervous system is queued through very distinct biological mechanisms that something isn't going right and therefore certain neurochemicals are deployed that will signal the neural circuits that they have to change. So let's talk about the experiments that support what I just said because I'm about to tell you that making errors over and over and over again is the route to shaping your nervous system so that it performs better and better and better. And I'm not going to tell you that the last rep of a set where you hit failure in the gym
Starting point is 00:17:35 is anything like neuroplasticity. You hear that too, that you know, it's pushing to that point of a cliff where you just can't function anymore. That's the signal. That's not the signal. That's a the signal. That's a distinct neuromuscular phenomenon that bears zero resemblance to what it takes to get neuroplasticity. So let's talk about errors and making errors, and why and how that triggers the release of chemicals, but then allow us to not just learn the thing that we're doing in the motor sense, the play the piano, dance, etc. But it also creates an environment to mill you within the brain
Starting point is 00:18:06 that allows us to then go learn how to couple or uncouple a particular emotion to an experience or better language learning or better mathematical learning. It's a really fundamental aspect of how we're built. And when you look at it, it's actually very straightforward. It's a series of logical steps that once you learn how to open those hatches, it becomes very straightforward to deploy. Last episode, we discussed some of the basic principles of neuroplasticity.
Starting point is 00:18:34 If you didn't hear that episode, no problem, I'll just review it quickly, which is that it's a falsehood that everything that we do in experience changes our brain. The brain changes when certain neurochemicals, namely acetylcholine, epinephrine, and dopamine are released in ways and in the specific time that allow for neural circuits to be marked for change and then the change occurs later during sleep. I'll review that later, but basically,
Starting point is 00:19:02 you need a certain cocktail of chemicals released in the brain in order for a particular behavior to reshape the way that our brain works. The question really is, what allows those neurochemicals to be released? And last episode, it talked all about focus. If you haven't seen or heard that episode, you might want to check it out about some specific tools and practices that can allow you to build up your capacity for focus and release certain chemicals in that cocktail. But today we're gonna talk about the other chemicals in the cocktail in particular dopamine.
Starting point is 00:19:32 And we're really gonna center our discussion around this issue of making errors and why making errors is actually the signal that tells the brain, okay, it's time to change or more generally, it's time to change or more generally It's time to pay attention to things so that you change and I really want to distinguish this Point really clearly which is that I'm going to talk today a lot about motor and vestibular meaning balance programs But not just for learning motor
Starting point is 00:20:02 Commands and and balance not just for learning new motor skills and balance, but also for setting a stage or a condition in your brain where you can go learn other things as well. So let's talk about some classic experiments that really nail down what's most important in this discussion about plasticity. So I mentioned last episode, and I'll just tell you right now, again, the brain is incredibly
Starting point is 00:20:25 plastic from about birth until about age 25. Passive experience will shape the brain just because of the way that the chemicals that are sloshing around in there and the way that the neurons are arranged and all sorts of things. The brain's job is to customize itself in response to its experience. And then somewhere about 25, it's not like the day after your 26th birthday plasticity closes. There's a tapering off of plasticity and you need different mechanisms to engage plasticity as an adult.
Starting point is 00:20:56 We're mostly going to be talking about adult plasticity today, but I got a lot of questions about, well, what about if I'm younger than 25? First of all, it's great. I wish I could, I wish I had a time machine, but I don't. Because as I've said before, the stinger is when you're young, your brain is very plastic, but you have less control over your experience. When you're older, generally, you have more control over your experience, but your brain is less plastic.
Starting point is 00:21:20 So if you're already asking the question as a 20-year-old or a 15-year-old, what can I do now that's really going to enhance my brain? I guess the simple question would answer, excuse me, would be an aside which we get the broadest education you can possible. That means math, chemistry, physics, literature, music, learn how to play an instrument. I'm saying that because I wish I had, et cetera. Get a broad training and a number of things and find the thing that really captures your passion and excitement and then put a ton of additional effort there. That's what I recommend, including emotional development, maybe a topic for a future episode.
Starting point is 00:21:55 But if you are an adult or if you are a young person knowing how to tap into these plasticity mechanisms is very powerful. You need these chemicals deployed in the nervous system in order to mark whatever nerve cells happen to be firing in the time afterward for change. And people are obsessed with asking, you know, what supplements, what drugs, what conditions, what machines will allow for that. But there's a natural set of conditions that allow for that. When we came into this world, we learned to take our different maps of experience.
Starting point is 00:22:34 Our motor maps, our auditory maps, our visual maps, and to link them, we align those maps. The simplest example is the one I gave before. If I hear something off to my right like a click, like that, it could come from my finger snapping or it could come from something, a, a, a, a, a, a, generate by somebody else or something else to my right, I look to my right. If I hear it on the left, I look to my left. If I hear it right in front of me, I keep looking right in front of me. And if I hear it behind me, I turn around. And that's because our maps of visual space and our maps of auditory space and our maps of motor space
Starting point is 00:23:10 are aligned to one another in perfect register. It's an incredible feature of our nervous system. It takes place in a structure called the superior colliculus, although you don't need to know that name. Superior collicas has layers, literally, stacks of neurons like in a sandwich, where the zero point right in front of me, or maybe, you know, 10 or 15 degrees off to my right, or 10 or 15 degrees off to my left, are aligned so that the auditory neurons, the ones that care about sounds, at 15 degrees to my right, sit directly below the neurons that look at 15 degrees to my right
Starting point is 00:23:45 in my visual system. And when I reach over to this direction, there's a signal that's sent down through those layers that says 15 degrees off to the right is the direction to look, it's the direction to listen, and it's the direction to move if I need to move. So there's an alignment. And this is really powerful, and this is what allows us to move through space and function in a lives in a really fluid way. It's set up during development.
Starting point is 00:24:11 But there have been some important experiments that have revealed that these maps are plastic, meaning they can shift their subject to neuroplasticity, and there are specific rules that allow us to shift them. So here's the key experiment. The key experiment was done by a colleague of mine. It was now retired, but whose work is absolutely fundamental in the field of neuroplasticity Erk Nudson. The Nudson Lab and many of the Nudson Lab scientific offspring showed that if one is to wear prism glasses that shift the visual field,
Starting point is 00:24:49 that eventually there'll be a shift in the representation of the auditorium motor maps to. Now, what they initially did is they looked at young subjects and what they did is they moved the visual world by making them wear prism glasses. So that, for instance, if a, if my pen is out in front of me at, you know, five degrees off centers, it's just a little bit off center. If you're listening to this, this would be like just a little bit to my right. But in these prism glasses, I actually see that pen way over far on my right. So it's actually here, but I see it over there because I'm wearing
Starting point is 00:25:25 prisms on my eyes. What happens is in the first day or so, you ask people or you ask animal subjects or whatever to reach for this object and they reach to the wrong place because they're seeing it where it isn't. This gets especially complicated when you start including sounds, when you have a thing off to your right, making a sound, but the thing is actually right here. So you're hearing the sound at one location and you're seeing the object at another location because you're wearing these prisms. So your image of the world is totally distorted. Or in experiments done by other groups, they wear glasses, subjects wore glasses, that
Starting point is 00:26:03 completely invert the visual world so that everything is upside down, which is an extreme example of these representational maps being flipped or shifted. What you find is that in young individuals, within a day or two, they start adjusting their motor behavior in exactly the right way so that they always reach to the correct location. They hear a sound at one location, they see the object that ought to make that sound at a different location, and they somehow are able to adjust their motor behavior to reach
Starting point is 00:26:36 to the correct location. It's incredible. It's absolutely incredible. Or in the case of the people who look at the world upside down, they somehow are able to navigate this upside down world, even though we're completely used to our feet being on the floor and not on the ceiling and people not walking at us by hanging off the ceiling like bats. Amazing.
Starting point is 00:26:55 And what it tells us is that these maps that are aligned to one another can move and shift and rotate and even flip themselves. And it happens best in young individuals. If you do this in older individuals, in most cases, it takes a very long time for the maps to shift. And in some cases, they never shift. So this is a very experimental scenario, but it's an important one to understand
Starting point is 00:27:20 because it really tamps down the fact that we have the capacity to create dramatic shifts in our representation of the outside world. So how can we get plasticity as adult that mimics the plasticity that we get when we are juveniles? Well, the Nudson Lab and other labs have looked at this and it's really interesting. First of all, we have to ask, what is the signal for plasticity? Is it just having prison glasses on?
Starting point is 00:27:49 No, because they did that experiment and ruled that out. Is it just the fact that the visual thing is over to my, appears to be far over to my right when, in fact, it's right in front of me? No. The signal that generates the plasticity is the making of errors. It's the reaches and failures that signal to the nervous system that this is not working and therefore the shifts start to take place. And this is so fundamentally important because I think most people think, oh well, practice
Starting point is 00:28:24 is going to be, I have to access think, oh well, practice is gonna be, I have to access beginner's mind, which is a great concept actually. It's about approaching things, expecting to make errors, which is great. I think I am a believer in beginner's mind. But people understandably get frustrated. Like they're trying to learn a piece on the piano
Starting point is 00:28:39 and they don't know, they can't do it or they're trying to write a piece of code or they're trying to access some sort of motor behavior and they can't do it. And the frustration drives them crazy and like I can't do it, they can't do it or they're trying to write a piece of code or they're trying to access some sort of motor behavior and they can't do it. And the frustration drives them crazy and I can't do it. I can't do it. When they don't realize that the errors themselves are signaling to the brain and nervous system, something's not working. And of course, the brain doesn't understand the words something isn't working.
Starting point is 00:29:00 The brain doesn't even understand frustration as an emotional state. The brain understands the neurochemicals that are released, namely epinephrine and acetylcholine, but also, and we'll get into this, the molecule dopamine, when we start to approximate the correct behavior just a little bit, and we start getting a little bit right. So what happens is when we make errors, the nervous system, I don't want to say freaks out because it's a very mechanistic and controlled situation, but the nervous system starts releasing neurotransmitters and neuromodulators that say we better change something in the circuitry. And so errors are the basis for neuroplasticity and for learning. And I wish that this was more prominent, prominent out there. I guess this is why I'm saying it.
Starting point is 00:29:45 And humans do not like this feeling of frustration and making errors. The few that do do exceedingly well in whatever pursuits they happen to be involved in. The ones that don't generally don't do well, they generally don't learn much. And if you think about it, why would your nervous system ever change? Why would it ever change? Unless there was something to be afraid of, something that made us feel awful will signal that the nervous system needs to change, or there's an error in our performance. So it turns out that the feedback of these errors, the reaching to the wrong location, starts to release a number of things. And now you've heard about them many
Starting point is 00:30:23 times, but this would be epinephrine. It increases alertness, acetycoline focus, and this is why frustration that leads us to just kind of quit and walk away from the endeavor is the absolute worst thing. But because if acetycoline is released, it creates an opportunity to focus on the error margin, the distance between what it is that you're doing and what it is that you would like to do. And then the nervous system starts to make changes almost immediately in order to try and get the behavior right. And when you start getting it even a little bit right,
Starting point is 00:30:56 that third molecule comes online or is released, which is dopamine, which allows for the plastic changes to occur very fast. Now, this is what all happens very naturally in young brains, but in old brains it tends to be pretty slow, except for in two conditions. So let me just pause and just say this, if you are uncomfortable making errors
Starting point is 00:31:16 and you get frustrated easily, if you leverage that frustration toward drilling deeper into the endeavor, you are setting yourself up for a terrific set of plasticity mechanisms to engage. But if you take that frustration and you walk away from the endeavor, you are essentially setting up plasticity to rewire you according to what happens afterwards, which is generally feeling pretty miserable. So now you can kind of start to appreciate why it is that continuing to drill into a process,
Starting point is 00:31:49 to the point of frustration, but then staying with that process for a little bit longer, and I'll define exactly what I mean by a little bit, is the most important thing for adult learning, as well as childhood learning, but adult learning in particular. Now, the Newtons lab did two very important sets of experiments. The first one was published in Nature, very important study, which showed that juveniles can make these massive shifts in their map representations, meaning you can shift the visual world using visual prisms, a huge amount, and very quickly, young individuals can shift their representations of the world so that they learn to reach to the correct location. They get a lot of plasticity all at once.
Starting point is 00:32:34 It happens very fast in the period of just a couple days. In adults, it tends to be very slow, and most individuals never actually accomplish the full map shift. They don't get the plasticity. And here we're talking about map shifts, but this could be learning a new language. This could be any number of different things that one we're attempting. So what we're saying is what I already said before, which is that we learn very well as youngsters, but not as adults after 25.
Starting point is 00:33:02 But then what they did is they started making the increment of change smaller. So instead of shifting the world a huge amount by putting prisms that shifted the visual world of all the way over to the right, they did this incrementally. So first they put on prisms that shifted it just a little bit, just like seven degrees, I believe was the exact number.
Starting point is 00:33:24 And then it was 14 degrees and then it was 28 degrees. And so what they found was that the adult nervous system can tolerate smaller and smaller errors over time, but that you can stack those errors so that you can get a lot of plasticity. Put simply, incremental learning as an adult is absolutely essential. You are not gonna to get massive shifts
Starting point is 00:33:45 in your representations of the outside world. So how do you make small errors as opposed to big errors? Well, the key is smaller bouts of focused learning for smaller bits of information. It's a mistake to try and learn a lot of information in one learning about as an adult. What these papers from the Newdson Lab show and what others have gone
Starting point is 00:34:10 on to show is that the adult nervous system is fully capable of engaging in a huge amount of plasticity, but you need to do it in smaller increments per learning epoch or per learning episode. So how would you do this? Well, let's say, for instance, I'm terrible at free throws. So let's say I wanted to learn free throws. I'm 45 years old, so I'm well past the, you know, 25 and under mark. I'm going to make errors, I'm going to make a lot of errors. If I go into learning free throws, knowing that errors are the gate to plasticity,
Starting point is 00:34:46 well then I feel a little bit better, but I still have to aim for the rim of the basket or the net, you know, basically, you know, showing how little I know about basketball, but I think I know the general themes around basketball, involves a net, a backboard, and a ball of course. So I go to the free-field line and I'll throw, how long should I go?
Starting point is 00:35:03 Well, until I'm hitting the point of frustration, and at that point, continuing probably for anywhere from 10 to 100 more trials, should be my limit. That should be my limit if I want to improve some specific aspect of the motor behavior. And so the question then is, what should I be paying attention to? What should I be focusing on? Well obviously trying to get the ball into the basket. But the beauty of motor learning is that the circuits for auditory and visual and motor more or less teach themselves.
Starting point is 00:35:35 I don't necessarily have to be paying attention to exactly what the contact of my fingers with the ball or some random feature like whether or not I'm bending my knees or not, the key is to try a number of different parameters until I start to approximate the behavior that I want to get a little bit better and then trying to get consistent about that. Now, many of you involved in sports learning will say, okay, well, that's obvious,
Starting point is 00:35:58 this is just incremental learning. But the key thing is in those errors. By isolating the errors and making a number of errors in a particular aspect of the motor movement, it signals to the brain that it's plastic. And if I leave that episode of going and trying to learn how to shoot free throws, my brain is still plastic. Plasticity is a state of the brain and nervous system. It's not just geared toward the specific thing I'm trying to learn.
Starting point is 00:36:25 So there are two aspects to plasticity that I think we really need to highlight one, is that there's plasticity geared toward the thing that you are trying to learn specifically, and then there are states of mind and body that allow us to access plasticity. Now, toward the end of this episode, I'm gonna spell out specific protocols
Starting point is 00:36:42 in a little more detail. That free throw example might not correlate with what you want to learn. Actually, I don't have a huge desire to learn free throws. I've more or less given up on basketball, but and free throws in particular. But I think that it's important to understand that motor movements are the most straightforward way to access states of plasticity. And that can be for sake of learning the motor movement or for sake of accessing plasticity more generally. One very important aspect to plasticity, getting plasticity as an adult is not just smaller increments, meaning shorter
Starting point is 00:37:17 bow. So I gave an example of another hundred free throws or something, but going out there and just getting my 10,000 free throws all at once or packing as much as I can into one one episode is not going to be as efficient for me as shorter bouts of intense learning as an adult because the error signals are not as well defined. To my nervous system, it's not going to know what needs to change. And so this is really the key element of incremental learning is that you're trying to signal to the nervous system at least one component that needs to change. And so this is really the key element of incremental learning, is that you're trying to signal to the nervous system at least one component that needs to change.
Starting point is 00:37:48 The nervous system needs to know what the error is. Now, when I shoot free throws, Lord knows, there are a lot of different kinds of errors that happen. Probably the way I'm bending my knees, the arc of the ball, the way I'm organizing my shoulders, probably where my eyes are, lots of things. So which ones to focus on? That's what I said before. The beauty of the motor system is, I don't have to worry about lots of things. So which ones to focus on? That's what I said before.
Starting point is 00:38:05 The beauty of the motor system is I don't have to worry about all of that. I just need to get the reps in a number of times and the nervous system will figure out how far off my motor commands are at the level of these maps that I described earlier. How far those are, those deviate from the desired behavior, getting the ball into the basket, and it will start making adjustments. But as I make adjustments, or as my nervous system makes adjustments for me, the key thing is to not start
Starting point is 00:38:36 adding a variety of new errors because then it gets confused. And so this is why short learning ballots are absolutely essential. So let's say it's for learning an instrument as an adult. Probably anywhere from seven minutes to 30 minutes is going to provide it that it's fully you're fully attending, you're very focused, is going to be a pretty significant stimulus to inspire plasticity in the nervous system. Now, there is one way to get a lot of plasticity all at once as an adult.
Starting point is 00:39:07 There is that kind of holy grail thing of, you know, getting massive plasticity as you would when you were a young person, but as an adult. And the Newtson Lab revealed this by setting a very serious contingency on the learning What they did was they had a situation where subjects had to find food That was displaced in their visual world again by putting prisms and they had to find the food and the food made a noise There was a noise set kind of the location of the food through an array of speakers
Starting point is 00:39:43 Basically what they found was that if people have to adjust their visual world in order to get food, the plasticity would eventually occur, but it was very slow as an adult. It was very, very slow. Unless they actually had the hunt that food. They actually, if they in order to eat at all, they needed plasticity. And then what
Starting point is 00:40:07 happened was remarkable. What they observed is that the plasticity as an adult can be as dramatic, as robust as it is in a young person or in a young animal subject, provided that there's a serious incentive for the plasticity to occur. And this is absolutely important to understand, which is that how badly we need or want the plasticity determines how fast that plasticity will arrive, which is incredible because the brain is just neurons and soup of chemicals. So what this, but this means that the importance of something, how important something is to us, actually gates the rate of plasticity and the importance of something, how important something is to us, actually
Starting point is 00:40:45 gates the rate of plasticity and the magnitude of plasticity. And this is why just passively going through most things, going through the motions, as we say, or just getting our reps in, quote unquote, is not sufficient to get the nervous system to change. This study, a beautiful study published in the journal Narrow Science, shows that if we actually have to accomplish something in order to eat or in order to get our ration of income,
Starting point is 00:41:17 we will reshape our nervous system very, very quickly. So the nervous system has a capacity, excuse me, to change at a tremendous rate to an enormous degree at any stage of life provided it's important enough that that happened. And I think some of you might be saying, well, duh, that's obvious. If it's really crucial, then of course it's going to change faster, but it didn't have to be that way. And for most people who are trying to learn how to learn faster or learn better, they probably, in most cases, they are hitting a limit
Starting point is 00:41:54 because the need to change is not crucial enough. And I think there are a number of places where this has important relevance in the, relevance in the people who are battling addiction, for instance. I will be the first to say that, you know, I sympathize with the fact that addictions have a biological component. There's clearly cases where people struggle tremendously to change their behavior and their nervous system in some cases is so disrupted by whatever substance they've been abusing or behavior that they've been engaging in, that it's that much harder for them to change. But we've also seen incredible examples where when people have to change from an internal standpoint, from their own belief and desire to change,
Starting point is 00:42:36 that massive change is possible. And so I think that the studies that Nudeson did showing the incremental learning can create a huge degree of plasticity as an adult, as well as when the contingency is very high, meaning we need to eat or we need to make an income or we need to do something that's vitally important for us, that plasticity can happen in these enormous leaps just like they can in adolescents in and young adulthood, that points to the fact that it has to be a neurochemical system. There has to be an underlying mechanism, right?
Starting point is 00:43:13 This wasn't a case of, you know, sticking a wire into the brain or taking a particular drug, all the chemicals that we're about to talk about are released from drug stores, if you will, chemical stores that already reside in all of our brains. And the key is how to tap into those stores. And so we're going to next talk about what are the specific behaviors that liberate particular categories of chemicals that allow us to make the most of incremental learning
Starting point is 00:43:41 and that set the stage for plasticity that is similar enough or mimics these high contingency states like the need to get food or really create a sense of internal urgency, chemical urgency, if you will. If you've heard previous episodes of this podcast, you may have heard me talk about all tradeian rhythms, which are these 90-minute rhythms that break up our 24-hour day. They help break up our sleep into different cycles of sleep, like REM sleep and non-REM sleep and in waking states. They help us, or I should say, they break up our day in ways that allow
Starting point is 00:44:18 us to learn best within 90-minute cycles, et cetera. So some of you might be saying, wait, you've been talking about all trading cycles in a moment ago, you were talking about seven minute or 12 minute or 30 minute learning cycles. Today we're really talking about how to tap into plasticity through the completion of a task or working towards something repetitively and making errors. And so just to frame this in the context of the Altradian cycle, you might sit down, decide that you're going to learn conversational French, which we're meeting that you probably don't already speak French. So you're going to sit down, decide you're going to learn some nouns and some verbs, you might do some practice. The Altradian cycle says that for the first
Starting point is 00:45:03 five to ten minutes of doing that, your mind is going to drift and your focus will probably kick in provided that you're visually, you're restricting your visual world to just the material in front of you, something we talked about last episode, somewhere around the 10 or 15 minute mark. And then at best, you're probably going to get about an hour of deliberate kind of tunnel vision learning in there, your mind will drift. And then toward the end of that, what is now an hour and 10 or hour and 20 minute cycle, you're going to, your brain will start to flicker in and out.
Starting point is 00:45:35 You might start thinking about what you need to eat or the fact that you have to use the bathroom or something. And then by the 90 minutes, it's probably time to just stop the learning bout and go do something else. Maybe return for a second learning bout later, but maybe take a nap afterwards or something to enhance the learning, but that it's going to happen within about a 90 minute block, you're going to go through that cycle of learning. When I refer to the seven or 12 or 30 minutes of making errors, what I mean is when you're
Starting point is 00:46:01 really in a mode of repeating errors, not deliberately, you're trying your best to accomplish something and you're failing. You're absolutely failing. You're trying to remember, say, the sign language alphabet. I was trying to teach myself this recently and then I kept repeating and repeating and then to get to a certain point where I kept making errors, making errors, making errors. You want to keep making errors for this period of time that I'm saying will last anywhere for about seven
Starting point is 00:46:29 to 30 minutes. It is exceedingly frustrating, but that frustration liberates the chemical cues that signal that plasticine needs to happen. And they also signal the particular neurons that are active. So in the case of sign language, it might be the ones that control my hand movements as well as thinking about what the different letters
Starting point is 00:46:48 are. It's signaling different components within the networks between the brain and body, and it's trying to figure out, wait, where are these errors coming from, where are the errors coming from? Ah, it's those neurons. They're making the mistakes. They're making the mistakes. They're making the mistakes.
Starting point is 00:47:04 And it essentially highlights that pathway for change. And it is the case that when we come back a day or two later in a learning bout after a nap or a night or two of deep rest, then what we find is that we can remember certain things and the motor pathways work and we don't always get it perfectly, but we get a lot of it right, whereas we got it wrong before. So that seven to 30 minute intense learning bout is within the all trading cycle. And I want to be clear about that. And some people can tolerate many of these per day. Most people can only tolerate one or two, maybe three.
Starting point is 00:47:39 This is intense work. If you know, shooting free throws, you could probably do it all day. But what I'm talking about is really trying to accelerate plasticity by having a period of the 7 to 30 minutes per learning bout that is specifically about making errors. I want to really underscore that. And it's not about, as I mentioned before, coming up with some little hack or trick or something of that sort. It's really about trying to cue the nervous system that something needs to change because
Starting point is 00:48:11 otherwise it simply won't change. Now there's another aspect to learning. I think it's only fair to mention, which is that we can all learn very easily when there's something very bad happens to us. And I don't wish this on anyone, but it is the case that if something really terrible happens that we will have a lifetime memory for that event. There are processes that allow us to uncouple the emotional load of that event. I talked about some of those a few episodes back, the episode on Dream's Trauma and
Starting point is 00:48:44 hallucinations, and we're going to return to trauma-released PTSD and some of those other themes in a future episode. But the reason why negative experiences can be wired into us so quickly is because our nervous system's main job is to keep us safe. But at a deeper level, it's because negative experiences cue us to the fact that whatever's happening that's really bad is very different than the other things that tend to happen before. So most of our experience doesn't remap us, but those negative experiences deploy high levels of norrapin effort and high levels of aceto-calling and really make so that whatever it is
Starting point is 00:49:22 that we experience in that bad episode is essentially queued up, and so we're on the lookout for it. And this has a number of negative effects, but in terms of psychological and emotional effects, but it is really a process designed to keep us safe. The other ways in which we can learn more quickly, besides just making errors, is when something really surprises us. And if we're positively surprised by something or we are just flooded with this molecule, dopamine, then there is a great opportunity for plasticity.
Starting point is 00:49:55 Dopamine is a molecule that's almost always associated with pleasure and with the accomplishment of a particular goal, but it's really also a molecule of motivation. It's a molecule that is released inside of us when we think we're on the right path. And it does have a capacity to increase neuroplasticity, motivation, et cetera. It's released in response to a number of natural behaviors, just that help with the progression of ours and other species, things like food, sex, in some sense, social connection, although that's more serotonin. And serotonin doesn't have the same effects on plasticity, quite the same.
Starting point is 00:50:34 And we'll talk about a few later. But dopamine is when we think we're on the right path toward an external goal, a little bit is released, and it tends to give us more motivation toward that goal. I think everyone could stand to enhance the rate of learning by doing the following. Learn to attach dopamine in a subjective way to this process of making errors. Because that's really combining two modes of plasticity in ways that together can accelerate the plasticity. So earlier I talked about making errors and having a focus about of learning that includes making a lot of errors inside of that learning bout.
Starting point is 00:51:12 That is going to be frustrating, but the frustration itself is the cue. And epinephrine will be very high under those conditions. But if you can just subjectively associate that experience with something good and that you want to continue down that path as opposed to quitting when you hit the point of frustration, well then you now start to create a synergy between the dopamine that's released when we subjectively think something is good or tell ourselves something is good and that situation of making failures. In other words, making failures if failing
Starting point is 00:51:45 repetitively provided we're engaged in a very specific set of behaviors when we do it, as well as telling ourselves that those failures are good for learning and good for us creates an outsized effect on the rate of plasticity. It accelerates plasticity. Now some of you might be asking and I get asked a lot, well how do I get dopamine to be released? Can I just tell myself that something is good when it's bad? Well, actually, yes, believe it or not. The thing about dopamine is it's highly subjective.
Starting point is 00:52:13 What's funny to one person is not necessarily funny to the next. So it has to have some sense of authenticity for you. But if you really want to be learning the thing that you're trying to learn, that should be reason enough to tell yourself, well, I'm frustrated. And but this, the frustration is the source of accelerated learning. Dopamine is one of these incredible molecules that both can be released.
Starting point is 00:52:37 According to things that are hardwired in us to release dopamine. Again, things like food, sex, warm, thome or cold, cool environments when we're too warm. It's that kind of pleasure molecule overall, but it's also highly subjective what releases dopamine in one person versus the next. So everyone releases dopamine in response to those very basic kind of behaviors and activities. But dopamine is also released according to what we subjectively believe is good for us. And that's what's so powerful about it. In fact a book that I highly recommend if you want to read more about dopamine It's a book that frankly I wish I had written it's such a wonderful book. It's called the molecule of more and it really talks about
Starting point is 00:53:19 dopamine not just as a molecule associated with reward, but a molecule associated with motivation and pursuit and just how subjectively controlled dopamine can be. So make lots of errors. Tell yourself that those errors are important and good for your overall learning goals. So learn to attach dopamine, meaning release dopamine in your brain when you start to make errors. Keep the bouts of learning relatively short if you're an adult. Younger people can probably engage in more bouts of learning. And it's
Starting point is 00:53:51 probably one of the reasons why they learn so much faster. They can just pack so much more information into the brains and nervous systems compared to adults. It's a little bit like a usually example of performance enhancing drugs. Some of those drugs probably do enhance performance at the level of increasing red blood cell count, etc. But a lot of what those drugs do is they allow athletes to recover faster so they can just train more. They allow them to do more work. And so being a child is a little bit like being in a performance enhanced brain milieu.
Starting point is 00:54:20 Their brains are kind of on natural, healthy neurochemicals that, that for them a lot more learning should they pursue it. So this goes back to my advice for young people early on. If you're young, what should you do? Learn as much as you can about as many things as you possibly can. And I suggest specializing in something. I guess I'm not in a position to give anyone direct advice, but I would say hopefully by about age 30, hopefully younger, you have some sense of what excites you and try and get really good at that thing provided it serves the world for better. But that's all I'll say in terms of parenting advice. It's not my place, but maybe sometime I'll have an episode completely devoted to sort of youth
Starting point is 00:55:06 and learning and youth. But once you're attaching dopamine to this process of making errors, then I start getting lots of questions. I really are the right questions, which are, you know, how often should I do this? And when should I be doing this? And at what time? Well, I've talked a little bit about this in previous episodes, but as long as we're now kind of into the nitty gritty of tools and application, each of us have some natural times throughout the day when we are going to be much better at tolerating these errors and much more focused on what it is that we're trying to do.
Starting point is 00:55:39 Last episode was about focus, but chances are that you can't focus as well at 4pm as you can at 10am. It differs for everybody depending on when you're sleeping and you're kind of natural chemistry and rhythms, but find the time or times of day when you naturally have the highest mental acuity, and that's really when you want to engage in these learning bouts. And then get to the point where you're making errors and then keep making errors for seven to thirty minutes. Just keep making those errors and drill through it. And you're almost seeking frustration. And if you can find some pleasure in the frustration, yes, that is a state that exists. You have created the optimal neurochemical milieu for learning
Starting point is 00:56:19 that thing. But then here's the beauty of it. You also created the optimal milieu for learning other things afterward. If you leave that bout of, I give the example of free throws, or maybe it's playing tennis, or maybe it's some other skill, and you sit down to read a book, your brain is in a heightened state to learn and retain the information. Because those chemicals don't get released and then it shut down, you're creating a whole milieu and environment of these chemicals. And the tale of how long these chemicals stay, you know, sloshing around in your brain has too many factors for me to put a hard number on it. It's going to depend on transporters and enzymes and all sorts of things.
Starting point is 00:56:59 But at least for an hour, so I would say, you're going to be in a state of heightened learning and the ability to learn not just the motor patterns but cognitive information, language information. Maybe you go to therapy right after that and you work on something in a very deliberate way that you're trying to work on. Maybe you don't go to therapy, maybe you do something else that's important to you. Again, there are just a variety of examples I could give. that's important to you. Again, there are just a variety of examples I could give. There are a number of things that allow us to powerfully access the states of error that are kind of surprising, but also kind of fun.
Starting point is 00:57:35 And these aren't, again, these aren't gimmicks, these tap into these basic mechanisms of plasticity. And the three that I'd like to talk about next are balance, meaning the vestibular system, as well as the two sides of what I call limbic friction or autonomic arousal. And if none of that makes sense, I'm going to put a fine point on each one of those and what it is and why it works for opening up neuroplasticity. Let's talk about limbic friction.
Starting point is 00:58:05 Now limbic friction is not a term you're going to find in the textbooks. So if any of my colleagues are listening, I want to repeat limbic friction. I realize it's not something you're going to find in any of the textbooks. But it is an important principle that captures a lot of information that is in textbooks,
Starting point is 00:58:23 both neurobiology and psychology, and it has some really important implications. Limbic friction is my attempt to give a name to something that is more nuanced and mechanistic than stress. Because typically when we hear about stress, we think of heart rate, heart beat going too fast, breathing too fast, sweating, and not being in a state that we want. We're too alert and we want to be more calm.
Starting point is 00:58:48 And indeed, that's one condition in which we have limbic friction, meaning our limbic system is taking control of a number of different aspects of our autonomic or automatic biology. And we are struggling to control that through what we call top-down mechanisms. We're trying to calm down in order to reduce that level of arousal. We're all familiar with this. It's called the stress response. However, there's another aspect of stress that's just as important, which is when we're tired and we're fatigued and we need to engage, we need to be more alert than we are.
Starting point is 00:59:26 And so what I call limbic friction is really designed to describe the fact that when our autonomic nervous system isn't where we want it, meaning we're trying to be more alert or we're trying to be less alert, both of those feel stressful to people. So the other way to put it is that the word stress is not a very good word to describe what most people experience is stressful because it can either be being too tired or being too alert. Now why am I bringing this up in a discussion about neuroplasticity? This is not a discussion about stress. At some point we will talk about stress and tools to deal with stress.
Starting point is 00:59:56 But the reason I'm bringing this up is that in order to access neuroplasticity, you need these components of focus. You need the component of attaching subjective reward. You need to make errors, all this stuff. And a lot of people find it difficult to just get into the overall state to access those things. So now there's a series of gates that people are having a hard time accessing. They're too tired and they can't focus, for instance.
Starting point is 01:00:24 Well, here's the beauty of it. If you are too alert, meaning you're too, you know, anxious, and you want to calm down in order to learn better, there are things that you can do. The two that I've spoken about previously on various podcasts, I'll just review them really quickly, are the double inhale exhale. So inhaling twice through the nose and exhaling once through the mouth. This is not some yogic trick or some hack. This is what's called a physiological sigh. Offloads carbon dioxide from the lungs. It has a number of different effects. These were described in textbooks and eating back to the you know the thirties and a number of laboratories have explored the neural circuitry underlying these so-called physiological size. That will calm you down faster than anything else that I'm aware of. The other thing is
Starting point is 01:01:09 starting to remove your tunnel vision. When you use tunnel vision, you very focus that epinephrine is released by dilating your field of gaze, so-called panoramic vision. Great. So now you can start to move up and down this level of autonomic arousal. The key is you want to be in a state of arousal that's ideally matched to the thing that you're trying to perform or learn. So if I'm really anxious and I can't even pick up the basket ball where I feel like I'm shaking or my muscles are too tight, I don't have that kind of looseness. Now when I move like that almost makes it look like I could throw a free throw, but I miss 95% of the time, unless the basket is very, very low and I place it indirectly, but
Starting point is 01:01:51 I guess that's not a free throw, is it? In any case, the point being that you want to be in a state of alertness, but calm, and so you need to have ways to calm yourself down when you're too amped up. But the other side of limbic friction is important too. If you are too tired and you can't focus, well then it's going to be impossible to even get to the starting line, so to speak, for engaging in neural plasticity through incremental learning, et cetera. So in that case, there are other methods that you can do to wake yourself up.
Starting point is 01:02:21 The best thing you should do is get a good night's sleep, but that's not always possible or use an NSDR non-sleep deep rest protocol. But if you've already done those things or you're simply exhausted for whatever other reason, then there are other things that I often get asked about, like sure, a cup of coffee or super oxygenation breathing, which means inhaling more than exhaling on average
Starting point is 01:02:42 and a breathing bout. These are now we're sort of getting toward the realm of how you could trick your nervous system into waking up. And if you bring more oxygen in by making your inhales deeper and longer, you will become more alert. You'll start to actually deploy nor epinephrine if you breathe very fast. So there are things that you can do to move up or down this so-called autonomic arousal arc.
Starting point is 01:03:03 And what you want to ask before you undergo any learning bout is how much limbic friction am I experiencing? Am I too alert and I want to be calmer or am I too calm and too sleepy and I want to be more alert? You're going to need to engage in behaviors that bring you to the starting line in order to learn. There are other things that you can do in order to then learn better and faster besides incremental learning and those center on the vestibular system.
Starting point is 01:03:31 And this may come as a surprise to some people, but probably not as a surprise to some of you whose professions or whose recreation involves a lot of motor activity and what we call high-dimensional skill activity, not just running or cycling or very linear activities like weightlifting, but things that involve inversions and a lot of lateral movement, actual sports, jumping, diving, rolling, these kinds of things, gymnastics type stuff. Why the vestibular system to access neural plasticity? Well, we have a hardwired system for balance, and here's how it works in as simple terms that I can possibly come up with. As we move through space, or even if we're stationary, there are really three main planes
Starting point is 01:04:16 of movement. Now, I realize some people are just listening to this, so I'm going to do this for both of the folks that are just listening and for those of you that are watching on video. So there are three main modes of movement and it turns out that your brain doesn't really know where your body is except when through that proprioceptive feedback. The main way it knows is through three planes of movement
Starting point is 01:04:36 that we call pitch, which is like nodding. So if I nod like this, that's pitch, then there's yaw, which is side to side, which is like shaking my head, no. And thenaw, which is side to side, which is like shaking my head, no. And then there's a roll from side to side, like when a puppy looks at you like, mm-hmm, that kind of thing, okay? So pitch, yaw, and roll.
Starting point is 01:04:55 And the pilot's out there, well, no exactly what I'm talking about. The brain knows the orientation and position of your body relative to gravity, depending on whether or not your brain is and your head actually is engaging more in pitch, yaw or roll or some combination. Because if I lean down like so or like so, it's a combination of pitch, yaw and roll.
Starting point is 01:05:18 I'll give you my second one. What is going on here? Well, we have these little things in our inner ear called the semicircular canals. Just like our eyes have two main functions. One is to see objects in space, and the other is to set our circadian clocks through subconscious mechanisms. Our ears have two main roles. One is to hear, right, to perceive sound waves or take in sound waves for perception, so called hearing.
Starting point is 01:05:41 And the other is balance or vestibular function. So sitting in our ears are these semi-cular canals and there are these little tubes where these little stones, they're actually little bits of calcium roll back and forth like little marbles. When we roll this way, they roll this way when it pitch, when we go from side to side, there's something that sit flat like this and they go shh, shh, like marbles inside of a hulu. And then we have roll, there's something that are kind of at 45 degrees to those and it's
Starting point is 01:06:04 kind of pitchy on roll. Okay, great. That sends signals to the rest of our brain and body that tell us how to compensate for shifts relative to gravity. I'm saying, okay, we thought we were talking about plasticity, but this is where it gets really, really cool. Errors in vestibular motor sensory experience, meaning when we are off balance and we have to compensate by looking at thinking about or responding to the world differently, cause an area of our brain called the cerebellum,
Starting point is 01:06:37 it actually means mini brain, and it looks like a little mini brain stuff, like tucked below our cortex in the back, cause the cerebellum to signal some of these deeper brain centers that release dopamine, norepinephrine, and acetocholine. And that's because these circuits in the inner ear, et cetera, and the cerebellum, they were designed to recalibrate our motor movements when our relationship to gravity changes, something
Starting point is 01:07:07 fundamental to survival. We can't afford to be falling down all the time or missing things that we grab for or, you know, running in the wrong direction when something is pursuing us. These are hardwired circuits that tap right into these chemical pathways. And those chemical pathways are the gates to plasticity. So I really want to spell this out clearly, because I've given a lot of information today. The first thing is, how are you arriving to the learning
Starting point is 01:07:33 bout? You need to make sure your level of autonomic arousal is correct. The ideal state is going to be clear, common, focused, maybe a little bit more on the arousal level, like heightened arousal. So understand limbic friction. understand that you can be too tired, in which case you're going to need to get yourself a little more alert, or you can be to alert, and you're going to need to get yourself calmer. That gets you to the starting line. When you're at the starting
Starting point is 01:07:59 line, then you're going to go into a learning bout, and that's when you want to start making these errors, okay? But what I'm saying is there's a layer in between where if you are interested in using motor patterns as a way to open up plasticity for all kinds of learning, not just motor learning, disrupting your vestibular motor relationship, meaning, and I'll tell you how to do that in a moment, can deploy or release neurochemicals in the brain that place you into a state that makes you much better at learning and makes making errors much more pleasurable. You're much more willing to do that. Now, some of you are probably saying flow state, flow state. Okay. I have friends that work on flow
Starting point is 01:08:43 states and who are involved in flow states and trying to figure out what they are. I have great respect for those people. So, when I, you know, tip my hat to them, very important work. But again, flow is an expression of what you already know how to do. It's what it's not how you learn. It's how you express what you've already learned. So I want to be really clear about that. It's been kind of presented as this super state or highly desirable state, but it's that, you know, we can all reach for. That's the wrong, wrong to reach for
Starting point is 01:09:13 until you already know how to do the things that I'm describing in my opinion. So the vestibular system, if you can engage the vestibular system and create some errors within the vestibular motor operations that you're carrying out, you create a neurochemical state that then makes you very very good at learning very quickly, regardless of age. So what would this look like? Does this mean just doing inversions? Well, does this mean doing yoga? Maybe. Does this mean taking corners faster on your road bike? Does this mean
Starting point is 01:09:43 This mean taking corners faster on your road bike. Does this mean, let's say you always swim freestyle or breaststroke, does this mean swimming backstroke or butterfly? It depends. It depends, however, on a very, very easy to understand parameter, which is how regularly you perform a particular motor behavior and how novel a behavior is. So the more novel that a behavior is in terms of your relationship to gravity,
Starting point is 01:10:11 the more it will open up the opportunity for plasticity. Have you ever seen somebody who just jumped out of the plane for a first time with a parachute? I don't even want to think about what. If you've just seen somebody who jumped out of the plane for the first time without a parachute I just hope the plane was on the ground But if you've seen somebody after that they are in this incredible state because their body and brain are flooded with all these Neurochemicals because it's very novel to them. However, you know I've got friends from communities that do you know have done thousands upon thousands tens of thousands of jumps and
Starting point is 01:10:42 They're always alert and aware, but it becomes pretty regular for them. That's the point. And they're not in this kind of buzzed out, excited state afterwards because it's routine for them. So the key is to bring novelty to the vestibular motor experience, the vestibular motor commands that you're performing. And how do you do that? Well, it's all about your orientation relative to gravity.
Starting point is 01:11:07 Now, I wouldn't want anyone to place themselves at risk. So if you can't do handstands, don't try and do them free standing and whatever. If you're good at handstands, guess how much plasticity doing a handstands for half an hour is going to create for you? Zero. Zero.
Starting point is 01:11:23 Your body is fully comfortable walking on your hands. I see these people walking on your hands, being upside down, being inverted, you know, your Cirque du Soleil performers, they're very comfortable there. And there is zero learning, zero plasticity because the failures and errors and the relationship to gravity are very typical for that individual. Now, what this means is that if we're going to use motor practices to open up plasticity for learning not just those practices, but some maybe some cognitive skills or other things in the period that follows, we need to create a sense of novelty relative to gravity. And that means being either in a new position or slightly unstable.
Starting point is 01:12:02 Believe it or not, I don't want anyone injuring themselves with a sensation of falling or close to falling, signals the cerebellum to signal the deep brain centers that release these neurochemicals, that something is very different and we need to correct this error very, very fast. Now earlier I was talking about high contingencies for learning and you definitely don't want to make it
Starting point is 01:12:24 like either survive this or die kind of experience. I confess I occasionally look at these parkour videos on YouTube and I believe in all of those people have died. The ones that do these ridiculous things of hanging off of buildings and these, I am not suggesting you do that, please don't do that. What I'm talking about is finding safe ways to explore the sensory motor vestibular space, as we call it, the relationship between those things. So that could be through yoga.
Starting point is 01:12:51 If you're terrible at yoga, there's more opportunity for you to learn than somebody who's very skilled at yoga, for instance, or gymnastics, or handstands, or on your road bike. This is unfortunately what I don't want to name brands, but stationary bikes where they give you the visual experience of moving through space, but you're not actually moving through physical space.
Starting point is 01:13:08 There's no vestibular feedback. It's all visual, right? You're stationary on the bike, right? So unless you're hanging off the bike in your living room, like almost to the point you're tipping the bike, you're not getting the actual vestibular motor sensory mismatch. That mismatch is the signal that deploys dopamine epinephrine and these other things. I don't care how excited or how much fun the ride was or how much music you're playing that you love. It's
Starting point is 01:13:32 not the same situation as being out of your normal relationship to the gravitational pull. So the first gate is to arrive at learning at the appropriate level of autonomic arousal. Clear and focused is best, but don't obsess over being right there. It's okay, be a little anxious or a little bit tired. Then you want to make errors. We talked about that, and this vestibular motor sensory relationship
Starting point is 01:14:00 is absolutely key if you want to get heightened or accelerated plasticity. And we talked about another feature which is setting a contingency. If there's a reason, an important reason for you to actually learn, even if you're making failures, the learning will be accelerated. So there's really four things that you really need to do for plasticity as an adult. And I would say that these also apply to young people. And there's an interesting kind of a thought experiment there as well, which is if you look at children,
Starting point is 01:14:34 they are moving a lot in different dimensions. They are hanging, sometimes hanging from trees, or I was kind of a, my sports were always things where I tended to get hurt a lot. Fall, lots, there's a skateboarding for me when I was a kind of a, I was, my sports were always things where I tended to get hurt a lot, fall lots. There's a skateboarding for me when I was younger. So a lot of falling and rolling and various things of that sort. But whatever sport the kids are playing, or even if they don't play a sport, they tend
Starting point is 01:14:56 to move in a lot of different relationships to gravity, more dimensionality to their movements I should say than adults. And one of the questions that's always kind always been in the back of my mind is, as we age, we get less good at engaging in neuroplasticity. Part of that is because, as the brain ages, there are certain changes to the way that neurons are structured, their molecular components, et cetera. But it's kind of a self-amplifying, or I should say,
Starting point is 01:15:23 a self-amplifying or I should say a self-generating cycle where as we get older, we tend to get more linear and more regular about specific kinds of movements. We get on the treadmill or we take the walk or we just always go up the same stairs, etc. There's less opportunity, for engaging these relationships to the gravitational pull through the vestibular motor sensory convergence that we talked about a moment ago. And so you sort of have to wonder whether or not the lack of plasticity or the reduced plasticity in older individuals, which includes me, would reflect the fact that those chemicals aren't being deployed because we're not engaging
Starting point is 01:16:07 in certain behaviors as opposed to we can't engage in the behaviors because the chemicals aren't being deployed. Now, I have a feeling it's both. These have a reciprocal relationship. And I certainly, again, I don't think it would be wise for anyone who doesn't have the muscle stabilizing skills or the bone density, et cetera, to start doing inversions and things of that sort. That's not what I'm talking about here.
Starting point is 01:16:30 But it's interesting to think about the sorts of exercise that we engage in. We all know that getting the heart rate elevated three to five times a week is really good for us for cardiovascular health. I think there's a ton of data to support that now. Some load bearing exercise is important for increasing bone density
Starting point is 01:16:45 and maintaining muscular strength and proper receptive feedback because I'm sure many of you know this, but resistance exercise actually trains the nerve to muscle connections as much as it does the muscles themselves, something I talked about at the beginning of the episode. But I think most of us could stand to increase the degree to which we engage this vestibular system in novel ways. And that can be done quite safely through a number of different mechanisms. I'm not a surfer, but people who do that sort of thing are very familiar with orienting their body differently according to the gravitational pole, or they're lying down, then they're standing up, then they're turning, they're leaning their head.
Starting point is 01:17:25 So again, it's this pitch-yaw roll thing. And again, if you're very skilled at surfing, you're actually not gonna open up plasticity just by surfing. It's in the learning of these new relationships to gravity that the windows for plasticity are enhanced. So I wanna make sure that I underscore the fact that this vestibular thing that I've been describing
Starting point is 01:17:46 is a way to really accentuate plasticity. It's tapping into an inborn biological mechanism where the cerebellum has outputs to these deep brain nuclei associated with dopamine, acetocholine, and orapinephrine. You don't wanna endanger yourself in the course of pursuing these activities, but it is a powerful mechanism.
Starting point is 01:18:07 That's an, kind of, an amplifier on plasticity. As is high contingency, if you really need to learn conversational French to save your relationship, chances are you're going to learn it. There are limits, of course, to the extent to which one can accentuate or accelerate plasticity. The ceiling on this is not infinite. Although we don't know how high it goes I think it's reasonable to say that if someone put a gun to my head and said learn conversational French in the next 120 seconds That conversational French would be limited probably to just one word probably the word we or something like that because I can't Stuff in all the knowledge all at once. I mean, I think that's the dream of brain machine interface that one will be able to download a chip
Starting point is 01:18:46 into their hippocampus or cortex or some other brain structure that would allow them to download conversational French. And someday we may get to that, as you know, that capability may come about. Right now it does not exist. Nor is there a specific pillar chemical that will allow you to download more information
Starting point is 01:19:06 more quickly. This is the issue around neutropics I've talked about before. There are things that can increase focus mainly things that increase the cytokoline and transmission through the nicotine system, things that can increase dopamine, things like altiracene. Again, I'm not recommending these. You need to heed the warnings on those bottles, but they will increase these neurochemicals. And there are of course things that will increase up
Starting point is 01:19:29 in effort and things like caffeine or some people because of prescription take Adderall. I'm again not suggesting people take any of these things. In fact, today I focused almost exclusively on behavioral tools and ways of structuring learning about that will allow you to access more plasticity regardless of age. And they center around things that I'm sure if you look
Starting point is 01:19:52 around you, you'll see evidence for, oh, incremental learning is powerful. Or, oh, the vestibular system can open up opportunities for plasticity. I'm sure the yogis out there are all saying, wait, this sounds exactly like yoga. We're supposed to push to an edge and do these inversions and do all those sorts of things.
Starting point is 01:20:10 Well, I want to be clear. I never said to anyone should do inversions. I said that the vestibular system is a valuable portal into some of these neurochemical states that favor plasticity. But not so seldom I hear from the yoga community and they will say things like much of what you're saying about how the brain works or Neural plasticity has already been described as embedded in yoga practices
Starting point is 01:20:31 And I just want to be very clear. I have tremendous respect for the yoga community and the practices I've done yoga from time to time. I find it challenging and valuable. I'm not a regular practitioner, but the problem with yoga is exactly the same problem with science, which is that yoga has a lot of practices for which there are very specific names, but no description or lending of understanding about mechanism. And science has a lot of mechanisms and a lot of publications and papers for which there's very little, if not no description of tools and practices. So my goal, not just today, but in many ways throughout the course of the podcast, is to bridge the gaps between these various disciplines in ways that are grounded mainly to the fields of neuroscience and some related fields. So yes, it's true that I look at things mainly through the lens of science, but that's not to say that it exhaustively explains everything about anything,
Starting point is 01:21:34 nor is it to say that it's the only lens through which one could look at something like neuroplasticity. So I just want to acknowledge that I have great respect for all these different practices and communities, and I think that indeed, there are many cases in which different communities and practices have been aimed at targeting the same goals or outcomes. Science and neuroscience through an understanding of mechanism can allow all of us to gain a kind of common understanding about what those practices are and how to access things like neural plasticity sleep, etc. And I do believe, as I've said previously on this podcast, that understanding mechanism
Starting point is 01:22:12 affords us a certain flexibility, and I don't mean physical flexibility. I mean, a flexibility when we can't engage in a particular behavior. Maybe we're injured or maybe we're not in the right situation to do a particular practice. But by thinking about mechanism, we can adapt our circumstances. I talked about this with sleep. If you're rigidly attached to one protocol of always looking at sunlight at one particular time in the morning and in the evening, that is not as valuable as understanding the mechanisms of why you might look at sunlight at one particular time versus another because that affords you
Starting point is 01:22:45 A flexibility allows you to adapt and life is very dynamic and we don't have control over all the external conditions all the time and so Understanding mechanism through the lens of neuroscience. I do believe can be very powerful because of course there are multiple ways to access dopamine There are multiple ways to adjust limbic friction. It's not just through respiration. Of course, there are many ways to do that. And so my overall goal here in this episode and with this podcast is to give you some understanding of the mechanisms and the insights into the underlying biology that allow you to tailor what these kind of foundational mechanisms are to suit your particular learning needs. I really thank you for your time and attention today. I've covered a lot of material.
Starting point is 01:23:32 I very much encourage questions in the comment section if you're looking at this on YouTube. If you're not and you're listening to it on Apple or Spotify, please feel free to visit us over on the YouTube channel and put your questions in the comments section. I do read them. This entire month is all about neuroplasticity. There's a lot to cover, but I'm very excited to delve deeper into this topic
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Starting point is 01:24:52 have been discussed on various episodes of the Huberman Lab podcast, and you will find various protocols related to those supplements. In the next episode of this podcast, we're going to continue to explore neural plasticity. This, as you may recall, is the way that we go about things here at the Hubertman Lab Podcast, which is to really drill deeply into a topic for three or four or even five episodes. So that by the end of those episodes, all of you have a very firm understanding of how to apply the principles of neurobiology to the specific practices and endeavors that are most important to you. So I very much thank you for your time and attention.
Starting point is 01:25:27 I know it's a lot of information and it takes a bit of focus and attention and certainly we'll trigger plasticity to learn all this information, I want to encourage you and just remind you that you don't have to grasp it all at once, that it is here archived and that if you want to return to the information it will still be here and that I most of all really appreciate your interest in science. Thank you so much.

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