Kyle Kingsbury Podcast - #271 Dr Ted Achacoso

Episode Date: October 1, 2022

Dr Ted is back and as good as ever. No master class lecture this week y’all. He didn’t fall short on the knowledge and incredible insight as always! We cover a ton so tune in and let us know what your favorite part was. Leave a rating and review for your chance to win my favorite Organifi products.   For a super sweet 10% off of Dr Ted’s Troscriptions click on the word and use “KKP” at checkout!    Connect with Dr Ted:   Website: www.homehope.org  troscriptions.com  biobalanceinstitute.com  Facebook: Dr Ted Achacoso  Show Notes:   KKP #199 Dr Ted Achacoso Spotify - Apple   Sponsors:   Organifi Go to organifi.com/kkp to get my favorite way to easily get the most potent blend of high vibration fruits, veggies and other goodies into your diet! Click that link and use code “KKP” at checkout for 20% off your order! PaleoValley Some of the best and highest quality goodies I personally get into are available at paleovalley.com, punch in code “KYLE” at checkout and get 15% off everything! Bioptimizers To get the ’Magnesium Breakthrough‘ deal exclusively for fans of the podcast, click the link below and use code word “KINGSBU10” for an additional 10% off. magbreakthrough.com/kingsbu  Our Sponsor - Aura offers all-in-one digital safety for your entire household. Identity theft, fraud, and malware are just some of their offerings. Go to https://aura.com/kyle for 14 days free and 40% off your plan.    To Work With Kyle Kingsbury Podcast   Connect with Kyle:   Fit For Service Academy App: Fit For Service Academy  Instagram: @livingwiththekingsburys   Odysee: odysee.com/@KyleKingsburypod  Youtube: Kyle Kingbury Podcast  Kyles website: www.kingsbu.com  Zion Node: https://getzion.com/ > Enter PubKey  >PubKey: YXykqSCaSTZNMy2pZI2o6RNIN0YDtHgvarhy18dFOU25_asVcBSiu691v4zM6bkLDHtzQB2PJC4AJA7BF19HVWUi7fmQ   Like and subscribe to the podcast anywhere you can find podcasts. Leave a 5-star review and let me know what resonates or doesn’t.

Hello, hello, everybody. We've got the return of Dr. Ted Achikoso back to the show, this time face-to-face. If y'all remember, or maybe you don't remember, I will link to it in the show notes, our first podcast together. Long time coming. I had first listened to Dr. Ted on Luke Story's Lifestylist podcast years ago and was blown away by his ability to, number one, his innate ability, first and foremost. I believe he has one of the top five highest IQs on the planet, but he doesn't just rest on his laurels. He's done a lot to educate himself in what is real world health and wellness, and what does it mean to actually be healthy? Many of you have heard of us talk about sick care in the past on past podcasts.

I love that term from Rob Wolf, the sick care system. So today we really focus on what does it mean to be healthy? And what is health care? And what does preventative care look like? And Dr. Ted has provided many programs for all people, not just doctors that want to continue their education. That field is slim. Let's be honest. But really people, coaches, people who want to understand this stuff, people who have their own health issues that want to really get right and understand the inner mechanics through the best of modern testing. Metabolomics, we dive into that. It's

been a long time since I've done an organic acids test, but I learned a shit ton from that test. What is my body breaking down? What is it not? He goes beyond genetics into epigenetics, into signaling, into seeing exactly how things are responding in the body. Am I digesting my food properly? Which supplements am I taking in and utilizing? Which ones am I not? All this stuff is there. And we really dive into much more than that. He has a very comprehensive education center online. That's a nonprofit. And we get a little bit into his nonprofit. What was birthed from that? How do we get people healthy right now? There is video of this that's going to come out later, but I have had the, I tell the story on the podcast, but I've had the most fucked up blue teeth for two and a half weeks because I took methylene blue and my teeth are super sustainable at the moment as I have loners

before veneers go in and I'll be podcasting with a really high-end biological dentist on why we decided to do that. So that's to come. But anyways, this podcast was hilarious because I was super on brand, having a completely blue mouth. Dr. Ted and his team, Dr. Scott, have created some really incredible products, one of which is Just Blue. It's a methylene blue lozenge. Another one is Blue Cannatine, and that has methylene blue, CBD, nicotine, and caffeine. And we really dive into what this is doing in the body, how it does optimize you. And stay tuned for next week because I have Dr. Scott, who also works closely with Dr. Ted

on the podcast. We did him back to back out at the farm. And Dr. Scott and I deep dive these products in more detail. But this conversation with Dr. Ted is really about him and it's about what he's created and who he works with in the world. And it is fantastic. One of many that I will have with Dr. Ted Achikoso. So thank you very much for coming on. Thank you guys for listening. There are a number of ways you guys can support this podcast. First and foremost, leave us a five-star rating with one or two ways that the show has helped you out in life. If you do at the end of every single month through the end of the year, September, October, November, December, we will pick one lucky winner.

That lucky winner is not random. It will be based on your five-star rating and what you have said about the podcast. And we're going to hook you up with my favorite product from Organifi. So Organifi is running this through the end of the year. If we like it and we get a lot of response, we'll keep doing this in early 2023.

Organifi has been one of my longest sponsors of this podcast. They do so much for the show. I just had a great podcast with Chase and Mimi from Organifi on the Medicine Podcast, which isn't out yet, but I'll be sure to mention that when it does release and link to that in my show notes on an upcoming episode. But it was cool. It was one of the first podcasts I've done with my wife. It was probably the first that we've done together, not on my show. So that was cool.

I had a blast. And I met those two at one of Paul Cech's modular workshops. They're frequents there. And I just love that everyone i've met from organifi has been an amazing person that speaks volumes to me about what kind of company they are who they're hiring and who's drawn to be a part of that you know i can't say that about anywhere else i've ever worked other than fit for service where like literally everyone i see there i'm like i fucking love you you're awesome you're a great. And you're funny as shit. And I want to hang out with you more. So that rarity is cool to see that. It's cool to see the game recognized game with the Organifi crew. They are fantastic. They are doing amazing things. They have made incredibly healthy superfood ingredients and

packaged them into very easy to consume, very easy to digest, low carbohydrate, and fantastic tasting. So again, how you make something fantastic tasting with low carbohydrate and it's organic, kudos to y'all. You did a great job. Each of their products, the green, the red, and the gold, there's their big trio. Each of them has very specific ingredients that are going to gear you up, gear you down. Adaptogens, mushrooms, all of which are designed to help optimize your day. And they don't do it in a one-size-fits-all way. They do it in a way where the plant medicine, like ashwagandha, can read your body and with the intelligence of that, balance you.

That's what an adaptogen does. And that's in the green juice alongside moringa and a whole host of other awesome ingredients. The red, which I've been taking before every single workout. I even take it in the morning now that I'm off caffeine and that gives me a big boost. The red improves blood flow. It improves nitric oxide production. It improves mitochondrial function with cordyceps sinensis, some master mushroom. All this stuff's in there. The gold, so good. It's got a massive dose of lemon balm. It's going to help you feel relaxed. It's highly anti-inflammatory with the turmeric and it tastes so freaking good. So it's my nightcap. Check it all out at www.organifi.com slash KKP and use code KKP for 20% off everything in the entire store.

That is O-R-G-A-N-I-F-I.com slash KKP. And do not forget KKP at checkout. Our next sponsor is another longtime sponsor, a must have. The only thing I take with me everywhere that I go is the grab and go. It's Paleo Valleys, Paleo Beef Sticks. They are absolutely essential. And not just when I'm traveling, but in my day to day. I'm constantly running around. Sometimes I don't even look at my schedule and I'm like, shit, I'm not going to be home until 3 p.m. And I don't want to skip lunch because I worked out the day before. I need protein, but I need it in a healthy way. I need it in a way that's not going to be loaded with nasty shit, chemicals, and everything else that I'd get at some fast food joint. I got to get it from 100% grass-fed beef from the United States that's going to have higher levels of

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And thanks again, Aura, for sponsoring this podcast. There we go. Cool. Dr. Ted, it's good to see you face to face and have you back on the podcast. Last time you took us to school, that was the easiest podcast I've ever done in my life. I still talk to people about that. I actually use that as a frame of reference when I do online interviews as the perfect

podcast for me. Because timing when you're not face-to-face can get jumbled with delays and things like that. Frequently, I hear it, even know, people, frequently I hear it, you know, even on other podcasts when I know somebody is doing one with another person out of town and it's online and they both get, well, well, well,

I'm going to jump in on that. And I was like, look, if I can lob you on your hands softballs and just let you run with it as long as you can, that'll be the best possible podcast. Yeah, actually, that's one of the easiest podcasts I did because I just handed out a straight lecture. That's what it was. It was perfect. It's like you're basically finished one semester in health optimization medicine and neuroscience

all at the same time. It was phenomenal, brother. It was absolutely phenomenal. And we're face-to-face now. And I love back and forth and face-to-face, but I also know who I'm sitting with. So I just want to prep this with, if you want to run with this thing, it is, the floor is yours, brother. I learned so much in that podcast. It was awesome getting to hear your background, getting to learn about bond and plant medicines and everything that have shaped you. And obviously being, you know, I'm sure one of my questions right now is, why would you choose to live in Washington, D.C.? Right? But just knowing what you're up to in the world, who you're connected with, and what you're able to teach, I'm sure that that's probably a big reason there. Yeah. Actually, Washington, D.C. was a destination of opportunity for me. And I was offered a faculty position

at the George Washington University Medical School in 1988. So I chose to be there. And, you know, I started my career there. You know, it's like money and power are surrogates of each other. So if you're looking for money, you go to New York. If you're looking for power, you go to Washington, D.C. And that's the thing that's there. And it's easier to see the terrible grants awards processes that we have,

which is incredibly bureaucratic. But then in the universities, the publish or perish situations, right? So while in the university, I was doing three things. I was doing clinics in interventional neuroradiology. At the same time, I was doing my teaching. And medical informatics before, the guy who mentored me was the guy who started the entire field. And it was very new. And we had to teach medical students you know how to teach how to use you know word and the spreadsheets and

and all of that little things that you need to be able to do on your own which are now you know skills that grade schoolers have but But by then, it was very new. The WordStar used to be the markup language. You had to put the tags in it so it would embolden and stuff. So it's been good to actually witness these developments. While in Washington, D.C., I was there when the electronic bulletin board system was still up. You dial up with 2,500 baud modems. And my classroom had 25 Zenith computers with 2,500 baud modems.

And in order to log into a bulletin board, you have to fire up all 25 of them at night. So, and whichever one goes in first is when you actually log into a bulletin board system. That's also the time of the internet when, you know, when you are presenting a problem, like a serious problem. And I was solving a problem on the Navier-Stokes equation, which was, you know, has no particular answer. It has to be an optimized answer. So there's several answers to it. The internet at the time was when the time that you could post that question

and the next day six Nobel laureates answered my question. So, yeah, and, you know, and it was downhill from there. And so it was, that was my world in Washington, D.C. And I suppose there's a certain inertia that keeps you there. But also some of my clients in health optimization are there, right? or working in the center of the universe of Washington, D.C., which is the U.S. capital. So it has kept me there for a while. And then after that, I actually retrained in underage medicine,

traditional medicine. So when I came back, that's when I got invited back to Manila and says, you know, it is actually very funny because I got a phone call and said, are you Dr. Teta Chikoso? She says, yes, you have a board certified in anti-aging medicine, yes. And you're one of the world's experts. I said, I don't think think so but if you say so

and says you're also board certified in traditional medicine I said man I know who's calling and this is from the office of the president sir

it's like it's time for you to take a look at what you can do here and I said no I'm perfectly happy commuting between Washington DC and Paris because I had a practice in Paris at the time and and I said no I'm

perfectly happy sir that was not a request so and then there I only did it like I saw a few high caliber clients and then I lectured twice. And pretty soon I got a really, really decent offer from the largest pharmaceutical company in Asia to turn them around into a health orientation rather than disease orientation. They reached out to you for this? Yes, they reached out to me for this. That's pretty forward-thinking. Yeah, they were very forward-thinking because they had a chief operating officer that was very much into, since they were a drug company, said, you know, there are no more new drugs that we really can give to patients anymore. And they said, this is where we have to get into health rather than disease.

And that's very forward thinking. I established actually two things for them. One is a pilot program of health optimization medicine. And that was in a clinic that was established for them and then i also pushed them to develop a very large laboratory for clinical metabolomics a detection of metabolized incentive cells it's actually uh when people see it they think it's a you know when i mentioned people think it's just a small laboratory it's actually intended to serve the uh 10 uh asean countries right so yeah yeah it was don don de gustino actually saw it's like oh my god this is actually a laboratory like it's huge

yeah that's incredible yeah um actually it was originally supposed to be in singapore uh but uh even the economic development board of singapore talked to us to me in particular setting it up there but um in the end you know their department of health decided that they really don't want to bring in uh biological samples from all over asia i said, let's set this up in Manila, right? And for half the price. So that was because of the mentality, right? If it's done in the Philippines, it's not good. If it's done in Singapore, it's good. So you have to Manila to practice.

And then so it became a rolling, you know, United States, Europe, Asia, United States, Europe. It's like once every month you're out there. That's why I think I mentioned in the last podcast to you that heaven for me is, you know, being in the same time zone for more than two weeks, man. I can relate to that. Yeah. We just came from LA. You know, I came from the Philippines for five weeks after two and a half years of absence.

They're the last country in Asia to open up. Actually, when I was there, they still even had mask mandates. Wow. Yeah. And this is just like four weeks ago, right? And two weeks ago. And I was in LA to deliver a lecture on GABAergic systems. And then I'm here with you.

So that's been my life going around. But before then, Washington, D.C. really afforded me to be mentored by the pioneer of medical informatics. The guy who started a social responsible investing movement in 1983 is also my best friend over there. It's actually very funny. We live two miles apart. But we see each other more in Asia. Whenever I'm in Manilaila he calls me he said dad i'm in hong kong let's fly over here and i have dinner and that's what happens instead of me having dinner with him two miles away you know he said hong kong is only like an hour away you're

on the same side of the yeah yeah yeah yeah so um that was the uh uh that was also my entree since he was the pioneer in what's now called impact investing. That was my entree into being on the other side of the table, the guy who assesses the science and technology of investments and being the science and technology advisor to all of these investment funds. So I know how that world works a little bit now, right? After, you know, I've been working with him for about 30 years now. So now that I have my own company, this is the second one that I really own. And, you know, with the transcriptions, that's the brand actually of Smarter Not Harder

is the name of the company Smarter Not Harder Inc my joke is that we're not a condom company right you got great one liners like that I like that a lot of hashtags that flow in a similar vein

yeah and transcriptions actually I started because of my jet lag, right? I made a product for myself. The one that has methylene blue, nicotine, CBD, and caffeine, right? And then people liked it. And then Just Blue was a customer request from us. And then I started, you know, anti-anxiety. Remember, anxiousness is a diagnosis.

We can't use that. It has to be an anti-anxiousness. It's jerky. Where it uses, you know, okay, geek out. An orthosteric modulator of the gamma receptor. Okay, geek out. An orthosteric modulator of the GABA receptor. So I'm kidding. It actually uses GABA itself, the endogenous ligand,

except that it's vitamin B3 complex to GABA. GABA doesn't enter the blood-brain barrier, right? So when you complex it with B3, it serves as a payload of B3. B3 crosses the blood-brain barrier. And so it brings the GABA inside. And then inside it hydrolyzes into vitamin B3 and GABA. And so you're able to raise your brain GABA levels. Explain that for people because a lot of people... I tried to explain this to my mother years ago.

Like, hey, you're taking boatloads of GABA. It's not going to cross the blood-brain barrier. I don't know which doctor is telling you to explain this to my mother years ago like hey you're taking boatloads of gaba it's not going to cross the blood-brain barrier i don't know which doctor is telling you to do this there are people that put ph gaba and various forms of these things and certain sleep medications things like that but explain from the top down we're really looking at gaba glutamate and what what what are those really sure to um uh most people do not pay attention to the on and off switches of the brain, right? They only pay attention to the superstar serotonin, which is in psychedelics, right? The 5-H2A receptors. They pay attention to dopamine, your famous dopamine fasts, right?

You pay attention to acetylcholine, which is elevated by your nicotine. You pay attention to norepinephrine, right? With guarana and all of those supplements. You pay attention to CBD, cannabinoids. You pay attention to your opiates, you know, which are produced by the body endogenously for pain. But I consider those as fish in the aquarium, right? Now let's pay attention to the aquarium and the water right where all of these fish are and that's the on and off switches so glutamate is the on switch of the brain and GABA is the off switch of the brain now glutamate is actually metabolized further

downstream into GABA so there's a delicate dance between your excitatory or your on switch and the inhibitory or your off switch. So now there's a difference between glutamine and glutamate. Glutamine can actually cross the blood-brain barrier, but glutamate cannot. So the blood-brain barrier is this barrier between your brain and the rest of your circulatory system, right, because the brain is a privileged organ. Meaning it will only allow certain molecules to diffuse and not others. So that selective permeability that we call, will not allow large molecules to come in, like GABA will not pass through the pore that's allowed for it, right? So if you do that,

then if you take lots of GABA, then it's in your body, you know, it gets hydrolyzed into the component materials. But it can actually even increase your energy, right? There's a part of GABA that can get back to the Krebs cycle to help you produce more energy. But what you do as a technique then is how do you increase GABA in the brain? Either you use a drug that looks like GABA, these are called GABA analogs, right? That looks like GABA and they can cross the blood-brain barrier and they sit on the receptor of GABA itself. Now, if it's GAaba uh gaba is called the endogenous ligand meaning it's the one that attaches to the gaba receptor right uh it's like

a lock and key right and then if it looks like gaba then it's called an um uh orthosteric ligand meaning it looks like uh but it it also resides in the same receptor. So an example of an orthosteric ligand which became illegal in the United States is gaboxadol. It was sold as a drug, anti-anxiety agent. It's longer legal here, but you can still buy it in Mexico. And it binds to the GABA receptor. So these are either the endogenous ligand or the orthosteric ligand. So what I have in Trocom is actually, so how am I going to pull this big molecule inside, right?

So what you do is you basically attach it to a molecule that actually can cross the blood-brain barrier, and that molecule happens to be niacin. So when you attach it to niacin, niacin then pulls it, and it will tug until the GABA actually gets into the brain. And then inside the brain, it says, okay, I don't need you anymore. We hydrolyze now, and the vitamin B3, of course, will be utilized by the brain, and the GABA will be your endogenous ligand for your GABA receptor. Now what's interesting about it is that this thing is titrated, right? So you've seen our trochees, there's cord, you can divide them into four.

Now most people use half, right? And the reason for this is that if you take too much, it will activate your brain instead of calming it down. Kind of like if you have too much stimulants at some point, you just shut down. Yeah, because B3 is a stimulant. So you have to make sure that you have the right dose. I formulated this as a way to basically calm down my thoughts they're reverberating circuits in the brain but most people have told me that they really like it uh like to take half of it an hour before sleeping because it quiets down their thoughts and they're able to sleep well well it's not a sleep formula but if you insist on doing it that way it's fine it's funny when you introduced it in in florida you know it was the moms who kept on

coming it's like oh my god this thing works of course of course of course the men who get this shit works man but the moms who keep on getting samples from us like this thing works um but i formulate again you know um i'm a fan a fan of developing uh you know things for myself right and it works for other people. It's great. And this is, so I was looking at what are we ignoring when we want to shut down the brain chatter, right? And just chill.

And I realized that we have been ignoring the aquarium and the water, right? We've just been focusing on the fish, like, oh, give more serotonin, give more this, give more that. And those are the superstars, right? But what about what turns them on and off? First, you got to have the water and aquarium. And then you focus on the superstars, right? And it's very funny because the GABA neurons are interneurons, meaning they form a connection between your superstar neurons.

I call them your neuromodulators. You can have one in between HE2A and a dopamine, for example. And that's the location of your switch, right? Because they have to be... GABA transmission is about 20% of brain transmissions, and 30% of synaptic transmissions is actually GABAergic in nature. So that's the reason why actually my interest in GABA has increased a lot more because this story about they did a test on the Japanese versus American children. Well, do tell. Yeah, it was an aquarium, right? And they showed the American kids, like, what do you see?

They said, we see three fish facing right. And that's the American kids. That's the answer. The Japanese kids said, there is an aquarium with water. There's a background of plants. They describe the context first and then they go to,

there are three fish, and they describe the location and so on. So we've become so foreground oriented in this society. Like we become so sympathetically oriented or foreground-oriented that we forget the context by which things are happening. Which is, you know, if you look at enlightenment, for example, the same thing, right? You're just focusing on foreground and you're forgetting the background

in which everything else is occurring. But it is possible to actually be able to step back and relax into that background and see that everything is just happening so so that's the uh the the kind of uh model that i have in terms of doing the uh that story emphasizes how we have overemphasized, you know, the foreground at the expense of the background. Another way of putting it is that, you know, you have this beautiful piece of literature, right? Say, very well written and say it's the House of Seven Gables or something like that. Some of these classics that are beautifully written, right? And you read them to savor them, right?

To savor how you paint with words, right? And then what do we do in college? We provide CliffsNotes, right? And we focus on the story instead of the style by which it's written. The whole story unfolds within the context of, you know, the brushstrokes of words, right? So then we miss the point, right? It's the point of writing that novel is not just to deliver the story,

but to deliver a great painting that's done in words, right? And so we're lost. We're just focused on the story and the whole reason for the exercise of reading that book is gone. To give you an example. So that's actually one of the reasons why I've been focusing on GABAergic and glutamatergic receptors. And GABAergic in particular because we just run, run, and run as a society.

We're a society of doers. Do, do, do without actually stepping back and saying, well, what's the context in which I'm doing this, right? It's kind of like the model that I did for my company, which is a reciprocity model, right? I say I started smarter and harder. Here are the prescriptions products. And then there's actually a nonprofit.

It's health optimization medicine and practice, right? So it's a reciprocity model one is very young like for profit it donates part of its profits to health optimization

medicine and practice which teaches physicians health optimization medicine non-physician healthcare practitioners right

like acupuncturists coaches etc on how to do proper health optimization I'd like to say that non-physician healthcare practitioners, right? Like acupuncturists, coaches, et cetera, on how to do proper health optimization. I'd like to say that disease is managed, health is optimized, right? So these are two different ways of doing things. And so the nonprofit drives the products of the for-profits. For example, it takes about three, six, nine months

before your hormones, nutrients, and other metabolites would balance themselves out, right? Because the bloodstream takes about 90 to 120 days to replenish itself completely. So I have, for example, husbands who come in, I'm just here because of my wife, you know? And then nine months later would come back husbands who come in I'm just here because of my wife you know and and then and then and then nine months later would come back as it never thought that

it would feel so good to feel so good to be this way but then there you know when you come in with pain sleeplessness anxious anxiousness, ADHD, etc. You're getting frustrated. We need to have immediate products that can address those immediately. And those are the products that I have been formulating for prescriptions, right? So it's also used for clinical practice.

In fact, TroCalm, which is the one that uses B3, GABA, and KAVA, by the way, it uses Kavein. Kavein, again, in the tradition of schooling people, in the GABA receptor, there's a site, there are actually various sites to which what's called allosteric modulators bind. So they do not bind within the GABA receptor itself, but they bind in the receptor and either augments or inhibits the action of the receptor. They do not work without GABA.

So GABA should always be paired with these allosteric modulators. An example is that in the GABA receptor, there's what's called a BZD site or the benzodiazepine site or the benzos or the valiums of the world, right? It's the most common prescribed anxiolytic worldwide. It has its own receptor. And you know me, Kyle, I have an itch whenever there's a receptor there.

Let's play with that. Push the button. Yeah, whenever there's a receptor there, it's like you button whenever there's a receptor there you wonder why there's a receptor there for this this body produces its own benzodiazepine like molecules because it has cannabinoid

molecules all of this and you find out that there are endogenous ligands for this and there's a benzodiazepine side in there that's why it's very effective. But remember, benzos do not function without GABA itself because it's just a positive allosteric modulator. If you do that, then you have to do it as a pair of GABA plus the benzo. The other thing that it has a receptor for, the GABA receptor has a receptor for ethanol, for wine, for alcohol.

So it has all of these different what you call allosteric modulators because they're not orthosteric. They do not occupy the GABA site itself, but other sites. And are they positive? Meaning they enhance the effect of the GABA or they're negative, right? So there are like two different, mainly two different types of GABA receptors, GABA A and GABA B. Some would claim a GABA C, but it's actually a form of GABA-A and GABA-B. Some would claim a GABA-C, but it's actually a form of GABA-A receptor. GABA-B is a different structure. And if you're an athlete, you might have used baclofen before for spasticity. That's more of a GABA-B receptor type of drug. But even, for example, for GABA-A, which has benzodiazepine side,

it also has a side for binding the drug for valium toxicity. Flumazenil actually has a binding site in there. So I have, whenever I see receptors in there, I say, hmm, what can bind here? It's like, it's my crack when I see a receptor and I say, but I usually am more, my direction is usually more what medicinal plants or what plants can actually produce molecules that can bind here. Yeah. Nature made it, right? Yeah. Long before pharmaceutical pharmaceuticals if we've got receptors and they have these different variants that are they're going to open to something that we may make internally but there also may be available yeah in in the pharmacopoeia of nature's

medicine cabinet like that that probably exists somewhere yeah um uh i have several projects right now where i'm you know the the what they're doing right now is investigating senolytic drugs, right? And I said, well, can we find, instead of making them into drugs, can we find a combination of natural products, like fisetin, quercetin, and all of that, that have been found to have senolytic activity, can we have more of those? And to approximate, say, the Yamanaka factors, right? So, to make us epigenetically younger.

So, when, it's very funny because, you know, I started health optimization medicine in practice and so on. And then I tested myself epigenetically. I'm 22 and a half years old, right? And you can only have the youngest as 22. I said, shit, I still have 0.5 years to go. Telomeres are more telomeric age, right? I'm 32. So there's a difference in the clocking mechanism.

Tell me about those. I've done a teloyears test before, which showed at the time that I was five years older, biologically than chronologically. And I was like, well, I have put myself through the ringer in college and football and fighting. I don't imagine that's the same now.

I haven't done a test in a long time, maybe five years, actually. It's been five years, and I've done a lot of right since then. But talk about the differences in these tests, because a lot of people hear anti-aging and, okay, how do I figure out where I'm at? Where's the starting place? Most people know if you're not checking your gas, you can feel is certainly not something

to discard. Feel is important, but also to be able to track that, track response. I like that. If you're not checking, you're guessing. In fact, that was the slogan of my company in the Philippines, don't guess, test. Because people ask me all the time, Dr. Ted, is vitamin E good for me? And this is vitamin A good for me? And is vitamin A good for me? And is this mineral good for me? I said, why don't we just check your metabolome, right? And we could see the levels of metabolizer. You could see very clearly, for example, your magnesium levels,

your vitamin B levels, all of them, right? And the technology exists now. It's called metabolomics. We've been so focused on genomics, we've actually forgotten who does the work or the metabolites. So that's the value of that. And that's metabolomic testing. These other tests that I mentioned,

these are the various tests of the different parts of the body or of the cell that can be tested vis-a-vis chronological age. So you have your chronological age, right? Which is 23, I'm guessing from looking at you. 40, close. And then you have the telomere test is actually, you know, telomeres are the end caps of chromosomes, right? They're just like the end caps of shoelaces. And each time the cell divides, it gets shorter and shorter and shorter.

So, but if you activate an enzyme called telomerase, those things actually lengthen back. Now, the way they do it is they compare the lengths of the telomeres. So the number of cell divisions that have been there, of course, will indicate the size of the end cap, right, of the chromosome. So there are cohorts like between 25 to 30, this is the average size of 40 and 30 to 35, this is the average size and so on. So it's a little bit more general in that sense. And what I found out even from my patients and from my clients is that if you push the mTOR pathway quite a bit, then your telomere age will actually be older, right? Your end caps will actually decrease.

And it's very simple to explain. For example, if you use growth hormone, right? If you use growth hormone, the rate of turn of intestinal cells will be a lot higher than if you were not. Same thing with higher levels of protein. Yes, yes, yes. They're trying to activate that pathway for muscle growth, correct? Yeah, if you activate a pathway for muscle growth,

then you will have a lot more of cell division, right? You introduce microterras in your muscle, and then it will have to rebuild new muscle cells. That actually pushes your telomere. It gets shorter. That's why you get bumped up in terms of age. So that's... Does fasting counter that?

Yes, it does. Okay. Yes, it does. I'm sticking to at least once or twice a year with fasting mimicking. I'm having really good results with that. I've done a couple water fasts. But that was kind of like the, can I have my cake and eat it too? Yes, you can.

Can I lift weights? Can I have higher protein intake? And then from periods of time, just have water. Yes, you can. Because there are two master regulatory genes, right? The one is the regulatory gene for the mTOR, the pathway, and the one is the regulatory gene for the mTOR pathway and the one is the regulatory gene for the AMPK, AMP kinase pathway. And the one is activated by leucine and branched-chain amino acids, and that's been proven. And the other one is activated by alpha lipoic acid.

So you could also mimic it during the day, right? Right after you eat, you will be pushed into mTOR mode. Take your alpha lipoic acid and it will dampen down the response, right? The anabolic response of food. So yeah, so those are master regulatory genes, which is actually covered in our health optimization and practice course, right? In a module called evolutionary medicine.

There's a module clinical metabolomics where you learn to read and analyze and give some implementation according to the metabolome results. But there are six other modules. One of them is evolutionary medicine where I describe all of those pathways. Because when we look at, for example, I used to troll bodybuilders was when I was asked, you know, by a 24-year-old who wanted to get married, right? And wanted to have kids and had no balls. So, and he said he has gone to doctors and no one would help him and said, this is so embarrassing for the profession, right?

Like, we even condemn people who use all of these anabolic services. The compassionate thing to do is to study what's actually going on and take a look at what could be done, right? So, you know, award winning bodybuilder, blah, blah, blah. And I said, no, no, no. I said, let's try to do this properly.

You know, let me study first that's how i really dove into all of this you know um structures of the anabolic steroids cycling this and that post-cycle yeah post-cycle therapies and all that and and then um you know in within two years he had i said now you have enough balls to get married uh and then they had a child actually that's amazing yeah uh and that's how i i because i took a compassionate stand right uh in in that said why aren't we helping these people you know they're asking for help and what we're doing is just condemning them uh for for using the ball probably grew up watching the same movies i did too you know he's watching arnold he's watching the whole program, he's watching all these guys. It's like, wait a minute.

I'm not going to look like that from weights alone. But the thing that I noticed, and this is after the master regulatory genes argument is that many of them are looking at the downstream portions of the cascade,

rather than looking at the upstream. So you start with the master and take a look. Very few master regulatory genes have been identified, but when you know them, at least you know to go up rather than down here. Oh, I'll take this supplement and that supplement and that supplement without knowing, you know, that's a downstream metabolite of an upstream process. So go upstream, right? And you find out that life is actually simpler. Bodybuilding becomes simpler.

Everything becomes simpler if you know where the upstream conditions are, what the upstream conditions are. And that's the kind of thinking that I like to put into these types of things. Like, for example, in telomeric testing, you know that it's going to be by cohort, you're going to push one pathway, you know that's going to increase cellular turnover, you know then that your cohort will be higher when measured in telomere age. Now, epigenetic age is different.

The way I like to explain it to my patients is that it's just like you build a plaque all over time. And to try to make you younger means to scale you to remove those plaques, right? One of the most common mechanisms, there are actually several mechanisms for epigenetics is the methylation of your, of your, you know, the, that the DNA is actually has an encasement, right? And they're histones. And that's why they're coiled into chromatin, right? So if you stretch them, it's about six meters long DNA, but they're coiled into these tiny things because they're coiled around chromatin. And then this actually determines, that's why it's called epigenetics, they exert control over your genes. And this is the argument, for example, that if you have a cancer gene, but you have the proper lifestyle, the gene may not be activated.

So you never know whether or not a gene will be activated or not. So for example, getting your breast lopped off just because you have the breast cancer gene is not necessarily a good idea. It may be based on family history and so on. But for me, I sort of like, you know, take a look at it and take a look at the measurements of your epigenome and take a look at your lifestyle, right? And because, you know, you never know whether or not your cancer gene will be activated or not, right? And what's interesting about the epigenetic tests is that they test for the methylation of what they call the CPG islands, right? The cytosine phosphate gonazine. And what's interesting about that is that as you get older, you know, you get more and

more plaque, more and more methylation. So in order to euthanize you, why are you TH? Euthanize. Actually, the proper term is to neotenize you why are you euthanized actually the proper term is to neotenize you right neoteny is a process of juvenileization and so in order to neotenize you then you will have to descale

or remove those plaques and that's what this you know things like quercetin fisetin and you know the satinib and all of those they affect your epigenetic age so when you're testing for epigenetic age like quercetin, fisetin, and the satinib and all of those, they affect your epigenetic age.

So when you're testing for epigenetic age, then they're only using one, but it's a major pathway for the aging, right? And it's a little bit more accurate. So what I do is actually I sometimes do an illness medicine challenge. So, okay, put your patient on diabetes, on metformin and all this other stuff. So let's measure the epigenetic age now.

And then six months later, you measure it and the patient is 10 years older, right? And then I put it on my protocol and said, here, we follow the pathways, we measure the metabolites. You know, the patient obviously lacks alpha-lipidic acid, magnesium, et cetera. You fill this out. Of course, the patient's taking a lot more

than just a single drug, right? But you see that after six months, the patient's actually gotten younger by 15 years. So you see how the difference is in terms of using what the body naturally uses by itself in order to balance itself versus drugs that have never been seen by the body in evolution, right? So it's just a matter of us being patient and being able to identify which particular tests, you know, can be useful to us in terms of not only, as I said, I'm not after disease management, I'm after the optimization of health, right? And epigenetics has been, you know, the subject of the work of Dr. Yamanaka in his Nobel,

his Nobel was based on the Yamanaka factors. These are the things that make you younger, the factors that make you younger, right? For those in the know, the abbreviations OSKM, I won't tell you what they are anymore. You can just look them up. But it's been used by David S sinclair out of harvard right for for essentially he crushed the optic nerve of i think rats or mice i i can't remember animal model

and then by just tweaking the yamanaka factors right right? They essentially made the cells, the neurons younger, and they knew how to reintegrate back into the nerve. They grew back with the proper orientation and the proper electrical signal to the brain. So that's a significant development for epigenetics, right? In terms of that. So that's sort of like one ofigenetics, right, in terms of that. So that's sort of like one of the modules that we have in health optimization medicine practice by itself is epigenetics. You have clinical metabolomics, of course, and then you have the gut immune system, which is the, you know, people assume that we all always know that the gut has the gut has been the largest immune organ that's only in the past 10-15 years really as you do that when I was a medical student it was a bone marrow man you know and when I was a medical student also we were taught that the thymus just involuted

and you know was not producing anything and they they found out we still produce about over 400 thymocines even if the thymus gland is involuted. So, and then we have the bioenergetics or mitochondria. Then we have exposomics as a module also, which is your total exposure to everything. And that's basically the toxins in your environment. But exposomics has always been a PhD type of subject and so we made it clinical in health optimization medicine practice and saying because in exposomics their unit of selection

is the gene, right? And everything around it is what is your exposure to. But in health optimization, the unit of selection is the cell and everything around it is your exposure to it. In illness medicine, it's the human and the organs, the unit of selection. So what I say in general terms, if you're just not looking at health optimization, you're looking at it in general terms if you're just not looking at health optimization you're looking at it in general terms then you know fetal alcohol syndrome a mother who's drinking it's part of the

baby's exposure is the alcohol because it's environment during that time so that's the total sum of your exposures until now. And that includes your exposures to x-rays, to, you know, EMFs and so on and so forth. That's the exposome, right? So in terms of us, we're looking at the cell, not the human body.

So what are the exposures, right, to the cell that affect everything else? Like for example, light can be toxic, phototoxicity, right? So then we could then see that. What I like to say is that you can, yeah, you know, use the genetic test, man, but you can never see mercury toxicity in a genetic test but you could see it in a metabolomic test right so you could see subtle toxicities borderline deficiencies in those tests the farther you move away from the gene the more you'll see the effect of the environment on you right and that's why i say we have become too DNA-centric, you know, but in order to overcome that, we have to use the metabolome instead to see what we are exposed to, you know, with what we eat, with what we drink, with exercise and other factors in environment like toxic relationships, not only with other people, but with work, with your house, with everything else, right? And then we also have the chronobiology module. Sleep is sleeplessness rather is an important issue.

And that's because we've forgotten that we're yoked to the sun. You're a farmer, you know this. I know, white belt, white belt farmer yeah you you uh wake up with the sun you know when the when this usually when the sun hits our skin our cortisol levels go up and so do our thyroid hormones right and then that wakes you up uh during the day right so that's that's uh these are natural things you know and then at night night you go to sleep and, you know, you have your melatonin to signal your body to sleep. People think that it makes you sleep.

No, it doesn't. It just signals your body to sleep, right? So these are the kinds of things that you cover in chronobiology, you know, your various chronotypes and so on. But what's more important there is the overarching theme of the whole modules that we are creatures of evolution, right? We evolved and we cannot just change things like that.

The world that we have created is not suited to our Model 4D bodies. So we have an impedance mismatch in there. So what do we do? We fight back with technology, right? You can have, you know, lights that change intensity and frequency throughout the day and so on.

I mean, we're smart enough to do that. But we're not well-informed enough to, you know, to disseminate information. So guys like you would be the platform to do so. There are many things that we could do to our lifestyle, etc. to mimic the optimal function of the make and model of our bodies, which is distinctly paleo, hunter-gatherer types of society. I like to say also that, you know,

the bodybuilding is actually, original bodybuilders were women, right? Because they would carry their kids, they would pick up the fruits. Carry water. Carry water and so on. Farmer's walks. The original mom exercise.

And the original aerobics were males because they would be running after their game. They take a look at the sun and orient themselves. And this also… I'm picturing a hunter-gatherer dressed like Richard Simmons right now chasing down an antelope. And it actually translates to the way we give directions, right? For men, when you ask them directions, go north, you know, hang left and da, da, da. But when you ask a female, oh, there's a gas station there, turn right. So it's more the local landmarks with no names, right? Just the names of what's inside the community.

So when you're hearing someone give directions, this has been written about, you know, you know whether it's a female way of giving directions, a male way of giving directions, you know, so, you know, you see the influence of being around the campsite most of the time and doing lifting,

heavy lifting work, right? Or the influence of someone who's been running around chasing prey the whole time, you know, and doing aerobic work. And so their orientation to landscape is very different. And then it's chronobiology and then there's, of course, evolutionary medicine, which I alluded to earlier.

What it is is really, you know, when you get an ankle sprain, you know, you will put weight off your foot by sitting down right you will have a swelling right the swelling and then you will you you basically don't want to see people you're irritable right that social isolation but what we do in illness medicine is you know okay let's immobilize it a bit more let's put it in a cast you know let's give you an uh an analgesic so you know you don't have any pain i'll put you in a crutch and keep you mobile so how much do we interfere with the natural process of healing right that's a question, fundamental question that's asked by evolutionary

medicine. How much do we interfere, right? The body already has its own wisdom to heal itself. So how much are we going to interfere with that? And, you know, there's no hard and fast answer to that. So they ask, evolutionary medicine asks the question, why do we get sick, right? And because the assumption in illness medicine is that all the signs and symptoms are signs and symptoms of disease. But in evolutionary medicine, all the signs and symptoms are actually the efforts of the body to get back into dynamic homeostasis, right? Back into balance.

So it's a different point of view together. And I made evolutionary medicine clinical by including the works of like Robert Navio in the cell danger response, right? He basically essayed in 2013 that the cell danger response evolutionarily, there are only eight ways, really only eight basic ways by which the body responds to stress, right? No other deviations from that.

It's just these eight major points. And if you realize what he's saying, you see that if you know what those basic eight things are, then you should be able to move from there and develop protocols by which you are able to help your patient or client. So as long as the stress is there, the body will activate the cell-danger response. You remove the stress and then the body begins to heal itself, right? So what's interesting there is that he says all of these responses are driven by metabolites. And all the metabolites that he's suggesting there that you measure, I was already measuring

since 2009. So it's like, okay, here's someone who's seeing what I'm seeing, right? And you could see their differences in summer and winter metabolism. And I said, actually, no, it's not just summer and winter metabolism. Your summer and winter metabolism can occur within a day, right? So when you're hungry, you are in a winter metabolism, right? After you eat, you're in a summer metabolism. So it eat you're in a summer metabolism so it is just a fractal of things right you could within a day then um have some particular lifestyle uh modifications that will be useful for you as you were saying earlier right um for me uh in traveling a lot you know i've been asked often, how do I maintain all of this?

Because I have to walk the talk, right? I can't be fat. I can't be too thin. I have to be able to lift my shirt up and show some stuff in there. I have to keep my veins. You got some guns, bro. I'm looking at... And I said it's really very simple. I maintain as much as possible. I maintain a feeding window of eight hours wherever I am, right?

You know, sleep, you could have jet lag. You know, you can't always be assured of your food intake. So make sure that you have ample vitamin, mineral cofactors, supplementation, even if you feel you don't need it, right? Because you can never be sure of what your diet is going to be. And besides, for example, when you are, we have a 12-hour time difference, right? I come from the East Coast and then head out to Manila. It's a 12-hour time difference or 13.

So by the time that I'm eating breakfast there, here, my intestines are closed for business, right? So you see there that you have to be kind to the cycles of your business, right? So you see there that you have to be kind to the cycles of your body, right? The cycles of your body, the last thing to change in jet lag is your gut, right? If you're used to pooping in the morning and you're still pooping at night where you are, then you're not yet adjusted, right?

So you listen to the cycles. I mean, you listen to the context of the health where health is happening, right? Rather than looking at the, you know, rather than you know a lot, you read a lot, you see, you grasp this concept and that, but you never listen to your body. You're fucked, man. Because ultimately, it's you and your body that knows what it is. Like, you know your body better than anyone else, right?

Some people just have egoic concepts of their body. You know, they think they're allergic to this and that, but when you test, there's really no allergy. I said, you just don't like to eat, you know, foods that are not caviar. So that's the, you asked me how I've come from Washington DC and moved out and trained in Europe and then come back

and now I'm doing all of these things and the major things that I'm doing now are essentially my reciprocity model of a non-profit to teach doctors and non-physician healthcare practitioners how to optimize health properly. And then descriptions which sponsors that and developing products that are for immediate use,

for immediate relief. So, yes. We touched on so much there. So much from the root causes to many usable many usables in there yeah i i said the summary is that we're after you know other people after the root causes of disease i'm after the root cause of health and it's only one right it's a balance between anabolic and catabolic processes according to your life cycle right so that's the root cause of health. So if you could do that, then you're all good.

I love it. I guess that in some ways summed up way more eloquently me lifting weights and eating high protein to then fasting. Yes, yes. No, that's a nitty gritty. That's where rubber meets the road. Ultimately, that's what you have to do. But on 33,000 feet, that's exactly what's the road ultimately that's what you have to do but on a 33 000 feet

that's exactly what's uh what's happening hell yeah well you guys have a conference coming up here um uh friday yeah what is the conference about what are you guys going to be speaking about i don't imagine this is going to be turned around in time for people to go to it but i would like get some eyes on on places where you guys are speaking at. We actually have a booth in there with our products. Phenomenal. Yeah. And since this is like a modern nirvana, right? I said, well, trocom is like meditation in a troki.

If you can't meditate, shove a half troki in there and chill out. Yeah. That's a good way to get good. Yeah. Yeah. That's what we're going to be doing there is this very cool having a booth yeah very cool yeah where can people take classes from you like that you mentioned and and is this open to everybody or yes it's open to everybody uh physicians and non-physician health care practitioners what we're particularly careful about is that if you're

a non-physician healthcare practitioner, we have to make sure that you know how to handle clients, right? And there's always a physician that if there are pre-existing conditions and comorbidities and the like, you know, there are physicians that will help you say, well, okay, this is the extent by which you can help. Because we always, if you're a physician, I always co-manage with other physicians, right? Your cardiologist, endocrinologist, et cetera.

But if you're a coach and so on, it would be a great addition to your arsenal to have a proof that you're actually improving the health of your of your clients so they can go to homehope.org that's h-o-m-e-h-o-p-e.org and it's an online it's an online course the course that is a prerequisite is clinical metabolomics where you could be teach you how to order tests, interpret the results, know the background behind the results, and write out your supplementations. So we're basically fully integrated from the testing to the prescription. And if it's just supplementary prescribing, then that's fine.

A health optimization practice will do it for you if you're not a physician. And we do have health optimization practitioners worldwide, like Australia, Netherlands, Germany, you know, UK. So I wanted this because I have a soft spot for non-physician practitioners because there are more people, there are more of those. More of you who are actually more passionate about their health rather than physicians

who are just passionate about disease or not even. So we'd like to encourage people to actually go and especially health physician practitioners to just come in. And then you get certified then on clinical metabolomics. And then there's a separate certification for the entire course.

We also have continuing medical education credits if you need those. Super cool. Yes. And recently we released cannabinoids for health optimization as an advanced module. There's also peptides for health optimization as an advanced module. There's also peptides for health optimization as an advanced module. And coming up will be psychedelics for health optimization and hormone health optimization. Those two modules will be done by me. That's phenomenal.

Yeah. Super cool. Well, you might have a new student on your me. That's phenomenal. Yeah. Super cool. Well, you might have a new student on your hands. Sounds great. Okay. Very cool. Where can people find you online?

Transcriptions.com. You know, I can be reached there or at homehope.org. I can be reached there as well. Cool. Yeah. Thank you so much for returning the podcast. And it's great to have you here face to face.

Yes. Thank you so much for actually this time and it's great to have you here face to face yes thank you so much for actually this time actually we're talking yeah beautiful brother thank you Thank you.