Moonshots with Peter Diamandis - Why We're Living in a Biological Singularity With Ben Lamm | MOONSHOTS Live #297

Episode Date: September 30, 2026

The Mates sit down with Ben Lamm at MOONSHOTS Live 2026 to discuss why we’re entering a biological singularity, from Anthropic’s move into biology and scalable gene editing to the possibility of a...rtificial wombs within the next 24 months. This episode was filmed at Moonshots Live 2026. Learn more at https://moonshots.com/  Get access to metatrends 10+ years before anyone else - https://qr.diamandis.com/metatrends   Peter H. Diamandis, MD, is the Founder of XPRIZE, Singularity University, ZeroG, and A360 Salim Ismail is the founder of Open ExO, a GP at Exponential Venture Capital/The Organizational Singularity Fund and a sought after global speaker and thought leader. Dave Blundin is the founder & GP of Link Ventures Dr. Alexander Wissner-Gross is a computer scientist and founder of Reified Ben Lamm is the co-founder and CEO of Colossal Biosciences, a biotechnology company using genetic engineering and AI to advance species preservation and de-extinction efforts. – This event is presented with: Google Circle Future Vision XPRIZE Partners: Salesforce ARK Invest Xsolla Range Build with Gemini XPRIZE Partner: Google _ Connect with Peter: ⁠X⁠ ⁠Instagram⁠ ⁠Substack⁠ ⁠Website⁠ ⁠Xprize⁠ ⁠A360⁠ Connect with Dave: ⁠Web⁠ ⁠X⁠ ⁠LinkedIn⁠ ⁠Instagram⁠ ⁠TikTok⁠ Connect with Salim: ⁠LinkedIn⁠ ⁠X⁠ ⁠Join Salim’s 10X Shift⁠ ⁠Subscribe to Salim’s YouTube channel⁠ ⁠Exponential Venture Capital⁠ Connect with Alex ⁠Website⁠ ⁠LinkedIn⁠ ⁠X⁠ Email ⁠Substack⁠  ⁠Spotify⁠ ⁠Threads Connect with Ben Website X LinkedIn Instagram Listen to MOONSHOTS: Apple YouTube Follow MOONSHOTS:  Instagram TikTok X Threads – *Recorded on September 25th, 2026 *The views expressed by me and all guests are personal opinions and do not constitute Financial, Medical, or Legal advice. Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript
Discussion (0)
Starting point is 00:00:04 I was a little terrified backstage when Palmer's like, there's something on the screen that says, I'm not supposed to say this. It's like, for the love of God, whatever it is, please not be, please don't make it about colossal. Please don't say it. So I remember at Abundance 360 last March, just before you came on, Elon was there. And he said, yeah, I want a pet woolly mammoth. How are you doing on that project? We get that request.
Starting point is 00:00:34 Yeah, yeah, but there was actually an amazing, I think it was either American Dad or Family Guy episode where they explained, did you see this? Yeah, I don't know if you guys saw this, but there's like, it's all over the end. It was amazing, and it was amazing because then at the end, they're like, yeah, and the woolly mammoths came out and they're about the size of a dog. That's actually how big they were. The fossils were just wrong, right? And it was like, amazing because it explains Christopher, but I was like, you know, we get the request. Like the number two requests we get is teacup mammoths. T cup.
Starting point is 00:01:04 T cup. T cup. Like, like, they want to take a mammoth and put it like, yeah, they put it in your purse, right? And so when, I mean, we can engineer new melanin, make it pink, and then Paris may well find them. So we're, uh, we are not working on that currently. But we're making good progress on the mammoth project. Amazing. So let me kick this off.
Starting point is 00:01:24 So you've started like four successful companies before a colossal and, you're, you know, in gaming and defense, in AI, in mobile. And so you knew nothing about synthetic biology. Yeah. Before you started, now a company worth over $10 billion. So why made you make the extinction your moonshot? And having no background synthetic biology was at a hindrance or an advantage? Oh, I think it's a massive advantage.
Starting point is 00:01:56 You know, I think that it affords you. me the opportunity to go into rooms of, you know, Palmer talked a little bit about this, too, but like hiring people to replace you and hiring people that are much smarter than you, right? And so I get, what's great about this from my vantage point is, like, I get to deal with a lot of the same bullshit, but at the same time, I can go in and, like, sit down with, like, best Shapiro and learn about ancient DNA extraction and, like, how not to do things. But then, like, the next meeting, I can go learn about, like, where we're pushing the boundaries of multiplex editing and how many edits that we can make at once, right?
Starting point is 00:02:28 And so I would say that, you know, I knew how to, and I guess in all of my career, I've known how to ask the right questions because I'm really curious. But I really do kind of subscribe to that old adage of like putting the top smartest women and men around you, just asking them questions, right? And so I get to go to meetings to just ask questions. And, you know, 90% of the time, I think people are like, okay, if you knew more about biology, this meeting would go faster. But then 10% of the time. But then 10% of the time, they're like, we never thought of it that way, right? By the way, this is such an important lesson for all of us as entrepreneurs, right? Just because you're not an expert in an area doesn't make it an area that you shouldn't go into if you love if you can attract the best talent around you.
Starting point is 00:03:12 Yeah, George Church, and like this is the only brag that I will say, which I'm very proud of. George Church says that I am the best student he's never had because I will literally just pepper him and be like, hey, my favorite times of the year are during holiday season. when like no one's working because I will just get on calls for hours and hours and hours of George Church and just talk about the possibilities with synthetic biology. Who's George Church for everybody? So if you don't know George, George is the father of, arguably the father of synthetic biology. He's the head of genetics at Harvard. And, you know, he's a lot of the next-gen read-write technologies that were invented came out of the church lab. And his lab's prolific.
Starting point is 00:03:49 There's been numerous multi-billion-dollar companies that have spun out of the lab. It's probably the probably most active startup biology lab in the world. And he's also like 6-7 with like narcolepsy and hilarious. And such a sweetheart guy. Yeah. And I mean, he is the most collaborative person ever, right? And so he's also like hardcore, even though it doesn't come from software, he's hardcore into open source and just like try the democratization of technology is like genome sequencing.
Starting point is 00:04:17 He wanted that to go from billions to $100. Well, she was very active in that category. And so he is literally just the most collaborative co-founder I've ever. you know, had the pleasure of working with. Dave? Yeah, I'm really curious about the business model of biology. And this is like, I think we all know that of all the use cases of AI that are imminent, you know, solving all disease, curing all pain is just like highest on the priority list.
Starting point is 00:04:42 The business model in biology is just always. Yeah. I mean, and it's great to get your perspective as a serial entrepreneur who came into biology from the outside. So my first question on like the business model is the foundation models. Like we just saw that like out of the box, Astra can drive a car. Yeah, yeah. Is it going to do biology out of the box, or do you say, no, no, no, no.
Starting point is 00:05:02 We need to build our own. So the foundation model is now, and we've been very fortunate to work with both OpenAI and Anthropic and getting early access to some of that stuff, which has been great. For a long time, we were leveraging it for kind of like thoughtful middleware, right, coming from a software perspective, where we were connecting lab notebooks and GER. I mean, one of the hardest things that we did at the company was retrain. scientist work in Jira. So that's harder than stem cell reprogramming at times. And so we actually, for a long time, you know, these, the LLMs before the frontier models, were really good at writing
Starting point is 00:05:41 term papers, right? They weren't really great at doing like ancestral state reconstruction or comparative genomics, right? Like that's where they just didn't work, which would have been amazing. So for a long time, we were leveraging them for kind of like middleware layers of infrastructure so you don't have to go higher the Deloits or extensions of the world to build all these. systems and reporting, right? So we did a, I think we were very successful at deploying that for a long, long time. Now they're getting pretty far where you can run simulation experiments. There's a bunch of companies out there that are standing up, Lila and others that are like trying to do lab automation around it, right? We've been pretty thoughtful about how and when we invest in that category.
Starting point is 00:06:17 But I think that what you're going to find is you're going to find interesting insights between connections that are really still language problems, right? So like, so for example, if you go search the literature on, you know, everything on mice, you know, if you just want to go build a new therapy company or whatever for humans, and you go look at all of the published papers on mice, many of them, they'll call a gene a different thing, they'll classify it differently, they'll run that experiment slightly differently, and so, you know, if you go try to run the exact same experiment, you're going to get, like, somewhere between 40 and 60 percent failure rate on published work, which is terrible, right?
Starting point is 00:06:55 So where I think AI is going to be really helpful in the next kind of wave of outside of like small molecule drug discovery, I think it'll be very, very helpful kind of eliminating that gap and bridging kind of that nomenclature between work. Like there'll be times where we'll do work and we'll find out later that there was a peer-reviewed published paper on one of the things that we were trying to solve. But the way we were looking for it wasn't findable on PubMever or whatnot. So I think in the short term it's going to bridge the communication layer. But I do think you're going to say, and you saw this, I think Anthropic announced this a couple of days ago, right? Where they've, and you have Ginko and others that are now going to test it. You're still going to need to have a wet lab experiment to test and validate those.
Starting point is 00:07:37 But running simulation design across a myriad of different experiments and helping creatively come up with the next experiment, I think that's where we're going to see AI and biology for the next, you know, three to five years. But what about this? Like, if I think about text data and research results, and going through thousands and thousands of prior tests, that's all LLM city. But what if my input vector is just a gene sequence? Like if I dump that right now into Anthropic,
Starting point is 00:08:05 pretty sure nothing good is going to come out. Yeah, but at scale. So thank you for the T-Up. So that is what I fundamentally believe is the importance of our global viable system that we're rolling out, right? So we're trying to roll out this like NOAA's ART-2 model not that no, I didn't get it really right in the first stage,
Starting point is 00:08:26 but at least ours is a slightly different. We're doing like A-TAC sequencing and other things that he didn't do. And so we're going out and trying to work with governments around the world to stand up localized biovolts to get all of that so that we can do T2T sequencing. And so to your point, I do not think that a single genome is going to, like you're not going to feed it into mythos, and it's going to be like, oh, well, if you make these six changes,
Starting point is 00:08:50 it's immortal, right? But I think that if you go look at like, you know, thousands of genomes across all these evolutionary lanes in avian species and see that they are not susceptible to many of these diseases, you'll look at that, right? We're doing that on a small scale with things like P53, Immoral Jellyfishes, other things, looking at kind of like known outcomes of the species and then try to backtrack it down the tree of life. So we're doing some of that right now at one of our companies, which we're pretty excited about, and early indications are positive. But to your point, you're not just going to be able to throw a genome in and it's going to be like, oh, here's how you fix it and makes it perfect. But I do think that that amount of data, from a comparative genomics perspective at scale,
Starting point is 00:09:36 it will get you there. But I also think that, so I would make the argument that, you know, the data set is more valuable than the model. Yeah, yeah, yeah. Because I have the data set. We've made that point so many times. Yeah. Alex. Yeah, I'd love to talk a bit about de-extinction.
Starting point is 00:09:52 I'm cognizant that you now have four-plus spin-offs, but nonetheless, de-extinction, I think, is still what you and colossal are perhaps best known. And certain things we're not supposed to talk about. We won't talk about those, though. So, de-extinction, there was a Russian philosopher, Nikolai Fyodorov, late 19th century, parent of a strain of philosophy called Russian cosmism
Starting point is 00:10:13 that argued that the ultimate trajectory of humanity in developing science and technology would be essentially to develop the technology to revive every human who's ever lived. Russian cosmism, you can look it up. So de-extinction. In some sense, you are... We're not doing that currently.
Starting point is 00:10:35 Just a clear of it. Good to know. But in some sense, by de-extinguishing, de-extincting various model species, including the woolly mammoth, you're the first company to mine. on Earth that at least has a plausible business model or at least technical trajectory to try to go after the entire historical biosphere.
Starting point is 00:10:56 So maybe not even just every human who's ever lived, but every non-human organism that's ever lived. Right. In an era of superintelligence where grand challenges are falling left and right, do you think that humanity's common task, as the 19th century Russian cosmos thought, that will ultimately have the technology, technology to revive every organism that's ever lived, or at least every human, do you foresee that becoming possible? I do not.
Starting point is 00:11:25 I think through DNA synthesis, prediction models and some components of synthetic, we will be able to get pretty close approximates. I don't think though, with two big caveats. Number one, just a second, for those other, Colossal does not use any of our technologies at colossal for humans. So we won't do that, even though I think our technology- Don't need a spin-off for that? Is that what you're saying?
Starting point is 00:11:51 I think that when you start working with humans, you need different, sometimes different investors, sometimes in definitely different governance, right? And you go through a different process. And more patients. And more patients, right? That was actually really good advice I got from Bob Nelson. Bob Nelson in the early days was like, hey,
Starting point is 00:12:08 don't apply any of this to humans for a while because you effectively go into like code freeze with the FDA and it's just a, like, you're just going to be in this monotony forever, go get to the technologies until they plateau before you then take them off. But back to your question, I think that fundamentally most organisms, remember these are the most organisms that we know. Very few people realize this, but there's less than like a hundred T-Rexes that have ever been, and I just want to go down the path, it'll scare you. There's less than like a hundred T-Rexes that have ever been found, right? But with that,
Starting point is 00:12:42 you know, there's billions that allegedly were on Earth. at different points in time, right? And so very few things leave a fossil record. So I think it's more likely that we will be able to engineer life from a programable life perspective in the way that we want it than just bring back everything that ever existed because I don't even think we know, right?
Starting point is 00:13:02 I think it's probably highly likely based on AI superintelligence at some point where we get to the point where we're saying, oh, we're gonna engineer this thing into your question, maybe it did exist, but we just never know because it left no fossil records, right? So I think it's more likely that we will be engineering life to our advantage than trying to bring back things. And even if colossal or a subset of our technologies, both cloning and genome engineering, can bring back things, as you know, environmental factors, epigenetics,
Starting point is 00:13:29 all these other things, like, if we could clone Mozart, that doesn't mean that he's going to come out and be like, oh, I'm going to, like, solve where the terrible trajectory of music has gone. Well, just maybe a follow-up question. So for Mozart specifically, we do know quite a bit about Mozart's life. So our arguendo, if we did want to resurrect Mozart, we'd have no problem at all with reconstructing his childhood environment. To a point, right? Like, to a point, right? And so I'm not in, and by the way, just to be very clear, I am not encouraging in any way this line of questioning, but we are taking humans and growing them. It's like, you're going to make, like, you're going to go down this like Michael Jordan LeBron super basketball team in a second and scare me.
Starting point is 00:14:10 So I do think it's highly likely that if we were able, or it's not highly, it's 100% accurate to say that we understand their genetic disposition and aptitude towards these certain traits. And under the right environments, if you want to go like, you know, if you want to go all simulation design on them and put them in the right environments, then they could probably, then your Mozart 2.0 could probably be better than the most. But Ben, let's bring it back to the animal kingdom because right now the whole thesis is that the AI systems can design the genome sequence that reflect a phenotype. So if you want an animal that's bigger. Is that 100% there yet? But that's the objective, right? If you want animal, that's got a longer snout or an animal that has wings. So like I asked you on stage at FII, you know, could you make a Pikachu?
Starting point is 00:15:08 Yeah, that seems to be a weird, like, fan favorite. You know, people are more accepting, I think, of Pikachu than these large genetic human camps that you're thinking. Branded species. Yeah, yeah, it is. Yeah, I think people are more open to that model of genome engineering than... But it sounds just maybe to tie a bow on this. It sounds like it isn't a technical objection per se. It's more worries of social, political, regulatory concerns.
Starting point is 00:15:33 Correct, yes. It's in ethical. So this is where I'd like to jump in. You know, in Stuart Brand, made this first. famous comment, Peter, the name is the title of your book, he said, we are as gods, we might as well start acting left. Yeah. And he said that in 1968.
Starting point is 00:15:49 We are at a point where you can de-extinct or bring back any species. How do you think through the ethics of what should we bring back? Which ones? Which ones shouldn't we bring back? So I'm a huge Stuart Fran. You know, I love him, love Ryan. That quote has been out there kind of like, you know, many from a, you know, a huge Stuart Fran. a famous dinosaur movie.
Starting point is 00:16:13 But I don't know if I would characterize it like Stewart and then get like on a plane. But from my perspective, I would say that we spend a lot of time. It is not plausible yet to bring back everything or engineer everything from a synthetic biology perspective. So we try to be very thoughtful. And people ask us, is there a checklist? How exactly do you go about selecting your species? Because there's a species that we've been very public about. and then there's species that we have not yet yet.
Starting point is 00:16:40 Hold on. I'm not talking about what you're doing specifically. Oh, you're saying philosophically. Generally philosophically, right? If we could bring back any species, who gets to decide? What evidence do you use to say, oh, bring this back or that? Just from a societal ethics perspective, how should we be thinking of it? Speciesism, right?
Starting point is 00:16:57 Yeah. Yeah, and so it's a great question, and because we're kind of the, you know, guinea pig in this world, the way that we think about it is what was their contribution to the environment? what was their contribution to the food web? Why did they go extinct? How do indigenous people feel about it? Some of the species that we work on, they have a deep spiritual connection
Starting point is 00:17:20 to the indigenous people side of it, right? So I don't think you're going to walk in and quote Stuart Brandoam. And so I think that it's very important to kind of like factor all those and weight those, and we're probably going to get it wrong, and I think society's going to get it wrong, but we're going to continue to try.
Starting point is 00:17:34 But then we also look at, like, is there an educational benefit to it? One of the things that we did when we did the Dyerwolves, right, after working with the Indigenous people groups and the Red Wolf Coalition teams and all these different components is we did, we did weigh in the pop culture nature to it. We thought, is there a way that we can bring all these people that focus on sci-fi and Game of Thrones and Magic the Gathering? Can we bring them to wolf conservation?
Starting point is 00:17:59 And can we bring them, can we teach them about genome engineering because we brought something back that they thought was only a mythological creature in their fantasy universe, right? So we try to wait all of these things differently. There's not a perfect kind of internal algorithm for how we look at it. But I do think that as the technologies proliferate and more governments start deploying our technologies, they will have to wait that on an individual basis. Yes, they will. And I'm sure that all of us are going to get it wrong at some point.
Starting point is 00:18:27 Well, because there's so many different factors involved, right? Like I'm some indigenous tribe and I worship the tax. Tasmanian devil. That doesn't mean you should or shouldn't bring it back. There's all sorts of other factors. We're going to have to think through that at a very, because the power that you're bringing to the table here is something that we've never seen in the history of humanity. Yeah, yeah, it is quite. You're like a walking singularity. Yeah, we are, we do, I think that society doesn't fully understand, I mean, they also address part. And I think that they've all heard like Ian Malcolm talk about it, but I do think he was really right.
Starting point is 00:19:07 Like, I do think that the technologies that are being developed with the kind of intersection of synthetic biology, compute AI, and then eventually quantum will be more powerful than any weapon system that's ever been created. Ben, we talk about solving everything. We talk about, you know, math is cooked, physics is next, chemistry and biology. Is there an inflection point, a singularity in biology where all of a sudden, there is a complete knowledge base of all the ingested DNA, all the ingested phenotypes, and you can literally design and work.
Starting point is 00:19:41 You can have like the CAD software for biology. You can design, you could prompt, give me an animal that does this. Yeah, I think that DNA synthesis isn't quite there yet. But project for me here. Yeah, yeah, yeah, yeah. So I think that world is less than 10 years out. Okay, all right, so you can prompt your favorite Pikachu or animal in a 10 years. whoever owns those technology should do it for you.
Starting point is 00:20:05 But I do think that the technologies of being able to engineer key phenotypes on base level organisms in different clades and be able to synthesize them or multiplex engineer them and then grow them ex utero is within a decade. Okay, ex-utero. Within the decade. Within a decade. Within a decade. Holy shit.
Starting point is 00:20:26 Can you make it? This is unbelievable. Well, let me give you a current curve, and this doesn't obviously mean that it's going to continue on this curve. But, you know, we were taking victory laps at 20 edits delivered. And I think that 99% of biopharma and, I'd say 99% of biopharma and academia would do that today. We are delivering 300 plus at 90 plus percent efficiency consistently, right? That was a year ago. Wow. We're now testing thousand. So that's an exponential growing curve. That doesn't mean it's going to continue, right? We're testing thousand. We're testing thousand.
Starting point is 00:21:02 curves, we're working, we're a thousand edit deliveries right now. It doesn't mean it's going to work. I'm working on it. Tripling year-over-year base edits? We don't know if it's going to work, but we are having to work. Early indicators have low efficiency, but it's working. But there is a point where large cargo swaps with DNA synthesis is just better. Unfortunately, the people in that category don't really have a business driver to synthesize
Starting point is 00:21:28 DNA after a certain scale. So we just started doing that internally. So doing the math, tripling year over year, you're at 1,000 base edits right now. That gives you like 12 years? We are consistently north of 300. We're testing 1,000. I think it's highly like we will get that working.
Starting point is 00:21:46 What's the point at which it kind of really goes crazy and you can do whatever you want? Well, I think the synthesis is going to, I think synthesis will replace multiplex editing faster. Right. So basically a machine that generates the, you know, the gigabase code you want. I think that has a higher likelihood of success faster.
Starting point is 00:22:04 Okay. So, Ben, you've come up with the artificial egg. Not the kind you eat, but the kind that gives birth to an avian species. How far are we from a lady here in the audience, a young lady or older lady in the audience, having a baby in an artificial womb? A human. Well, from a technology perspective, I think it's a very different answer than a societal and acceptance and ethics and reginal.
Starting point is 00:22:30 Okay, okay. So let's talk about an artificial womb for a mammal. Yeah, I think within 24 months, we will colossal will birth animal, mammals, fully ex-utero. From gestation through delivery. Yeah, that never went into a surrogate. Wow. That's pretty amazing. Yeah.
Starting point is 00:22:49 That's wild. Hopefully sooner, but I think that 24 months is highly likely. Wow. I need to ask a quick question. Just show of hands in the audience. Is you're mind blown? Like, okay, just checking. Okay, got it. Make sure I'm not alone here.
Starting point is 00:23:07 So what's the iPhone moment in Colossal here? Is it the Willie Mammoth stepping onto the stage? Or is there something else that like... I think that it's... A WTF moment. I think, well, I mean, I think we've had a little bit of those already. But I think that... You have.
Starting point is 00:23:25 I think the next major inflection points are when we show the world the next extinct species, right? Like I think always that's kind of zero to one mindset. That's next week. When is that? Just kidding. Coming soon. So I think that showing another extinct species back through precision genital editing, number one. Number two, I think that mammalian artificial development and gestation is number two. And then, you know, we are working on some things that we haven't shared yet that I think are
Starting point is 00:23:59 equally as interesting to like dire wolves. So we have some more surprise and delights if that surprised you and delighted you. If that's surprised and scared, well, then we have that for you too. Can I ask you about the data? So, you know, protein folding just really snuck up on everybody. Yeah, yeah. Like solved overnight. Yeah.
Starting point is 00:24:18 It's just a total gold line of change for all of biotech. and my daughter uses it every single day. Yeah, we use that. I mean, yeah. Massive. So the equivalent, the genotype to phenotype mapping problem where you say, okay, this sequence produced that, oh, that's Alex Wizzner Gross. Okay, this sequence, oh, that produced the lame.
Starting point is 00:24:34 Great. This is, oh, that's a Dota. Okay. I love this final jump there. Just a couple of us. We'd love that jump, by the way. So is there a point where, given the data set you're accumulating, you can interpolate and you can say, okay, now I don't have to create it.
Starting point is 00:24:49 I know exactly what would come out. So we're doing it on a, from a product perspective, we're doing it on a species basis currently, or we're trying to extrapolate to large clades of animals. So, like, sizing's a big one, right? So if you go, if you're taking, like, our model species that we're working with for the Tasmanian tiger, or thylotine, is a fat-tailed dunn art,
Starting point is 00:25:11 and it's a 1,500x fold from a marsupial mouse to a marsupial wolf, right? So understanding that and extrapolating that and how that, whether, what regulates that, not just the genes, but how and when it regulates in development, how does that transfer to, like, you know, can you make a killer whale the size of, you know, your pet goldfish? Probably not, but you could probably scale within certain levels of function. If you look at certain species like dogs and also certain species groups of birds,
Starting point is 00:25:43 they have tremendous scale functions, right, which are larger than 1,500. And so we're 1,500 X. So we're looking at it from a non-trait engineering perspective, but from a purest perspective in the extinction, to look specifically of the genes that drove X, Y, and Z. But separately, we are then trying to extrapolate that on a clade basis so that we can say, okay, how can we affect sizing, even within some marginal 20, 50% offshoot within other species.
Starting point is 00:26:14 So I think that it's likely that like coat, coat color, sizing, you know, placate, like things that form skin, scales, feathers, all of that will be highly measurable. Yeah. And be able to be inducible very quickly. Interesting. So I don't know about everything, but, like, you know, we have a whole AI team that's just working on patterning and stripes. It's actually a really hard problem. Tusks, stripes, length of snout, hair? Hair, yes, hair.
Starting point is 00:26:48 Yeah. By the way, though, you know, when Chris and I took our boys down to Dallas to visit, it was a real surprise and delight to see the Willie Mice there. Yep. How many gene edits did that take? The first generation, which is what we've shown in the public, was eight. Yeah, amazing. In one delivery.
Starting point is 00:27:08 Eight base bears. Eight edits. Eight edits. Eight base edits in one delivery. Amazing. Let's go to some of the audience questions here. This is from Bruno. We may have another version at some point.
Starting point is 00:27:21 Okay. I can't wait. Yeah, that's interesting. We'll have you back on moonshots to talk about it. Great. All right, so Bruno asks, must a moonshot tackle one of the normal problem? We had Shatner there the other day, and I was like, fuck, if we should have had a tribble. Oh, yeah.
Starting point is 00:27:34 Yeah, like, we made this carrier and tailless, we could have gotten, like, you know, Shatner very excited about a triple. Yeah, probably a tribles. That's right. We need triples. You can bring triples back. I think back is the wrong word, but I think we could move it here. Bring them forward. Yeah. All right, so Bruno asked the following of you. Must a moonshot tackle one enormous problem within a single vertical? Or can it be horizontal addressing a seemingly mundane everyday need that cuts across many verticals?
Starting point is 00:28:06 And we'll ask that of Astero as well, Captain Moonshot shortly. I think it can go across cross verticals, right? But remember, I have ADD, and so I think that the lack of focus gives us a larger amount of wisdom across multiple categories, right? And so we look at de-extinction as a systems problem, but that same system modeling that can be used to preserve species, bring back species, can also be used to do all kinds of work specifically in human health care. So I think that if you ground your fundamentals and what you're trying to build, I think you can, apply it to many use cases and it doesn't have to be so narrow that like if you miss that window it doesn't have other broader applicability. Here's a great question from Teresa. How are you planning the ethical issues in creating mammals ex-utero? A mammal has emotional needs and just creating
Starting point is 00:28:56 an animal doesn't relieve you of the emotional burden of a leaving creature. Yeah, that's the same thing. If it's born ex-euterro, do you give it a family to live? Yeah. So we do a lot. I think most people don't know this because, like, you know, the media doesn't always cover all of the stuff that we do. We have a foundation, we open source all of our technologies for conservation. So anybody can use any of our technologies for conservation for free. We have 75 global partners. We're very grateful for them. But we've also funded projects specifically around this, right? So, like, mammoths and elephants are highly social animals, right? So we're not going to bring a mammoth. We're bringing back herds of them. We have 16 different lines being worked on at the same time.
Starting point is 00:29:35 How many? We have 16 different lines working. No, no, how many total mammoths do you want to bring back? Do I want to bring back? Tens of thousands. Tens of thousands of mammoths. Yeah. Wow. In L.A.? It'd have to be Colombian mammoths for here or pygmy.
Starting point is 00:29:48 I'm going to steal your line. The mammoth in the room is where do the mammoths go? But going back to that, wait, wait, wait, wait, wait, wait. Yeah, I want to answer the, because I think it's a really important and thoughtful question, right? And so you've had, you've had, you know, California condors. You've had all these different, close to extinct species that people work on. and the rearing of it. And so we find, while there's a halo effect of the positivity of this for today, for elephants,
Starting point is 00:30:16 it also has a broader implication for what Colossel is trying to do. We find in Botswana an incredible group called Elephant Havens, which is working with orphaned elephants, right, that have already been born, not actually has a robot, but been abandoned for whatever reason, and they are working to use AI, they use a lot of different tools to figure out how do they create synthetic herds from a very major. patriarchal society of elephants where they don't currently get that. How do they rear those elephants and train them to be elephants and also work together in a herd, right?
Starting point is 00:30:47 Because that's how elephants behave. Separately, we're funding and doing research in everything from satellite imaging to drones, AI, building programs in different elephant migratory patterns in corridors so that we can understand the social dynamics and hierarchy of moving, right? And so that benefit, all of that technology in that data impacts elephant conservation work today, right? Right? So you don't have like orphaned elephants. You can rewild the entire herds.
Starting point is 00:31:18 But all that that data also informs us how we are going to rear these animals in a way where if they are born ex-chutero, how do they grow up in a social dynamic with the right hierarchy? Dave, you were going to say? So true story, your guy, George Church, was at a presentation that we had at MIT. and the topic was global warming. And he said, well, I have the cure for global warming. We have several, but yes. We're going to bring back the woolly mammoth. The Willie mammoth native habitat is Siberia and northern Canada.
Starting point is 00:31:49 The tundros. The tundras. And back when they were around, there were no trees because the willy mammoths walk around and knock down all the trees. And elephants actually do this in Africa too. Yeah, yeah, they're incredible at this. So we're like, well, what the hell is the connect? to global warming.
Starting point is 00:32:06 It goes, well, without the trees, the grass grows. The grass actually sequesters more carbon than the trees do. Yeah, it's about six times more efficient and a two to three X albedo effect for light reflection to space. Yeah, so I don't think you guys checked in with the Canadians to see if it's okay, but you turn on loose, turn them loose in Canada. I don't live in the tundra. I'm from India, actually.
Starting point is 00:32:28 Seriously, though, where do we build Jurassic Park? Yeah, 10,000. This is a really good point. So in the early days, and I'm a big data guy, so I, most of my background's in software and a little space hardware, but for the most part, I just want to go where the data takes us, right? Right. So you have high conviction, really smart scientists like George that will say if you have this mammoth density at these places in the tundra, they'll have this impact on the promorfrost, a lowering of six to eight degrees in the summer months, it only melts so far. So you can extrapolate that out. We have actually done that exercise.
Starting point is 00:33:04 And it's quite interesting. Then, but it goes back down to a top-down versus a bottom-up approach of how they affect the environment. There's other people in the scientific community, including a colossal, that think that they will not have that level of impact, right? But the good news is that generally speaking, whether they fall on the, what does, how do you solve climate change with mammis at 10,000 plus mammis in the Arctic, doesn't really matter because they have a net positive benefit on the environment in terms of, of like helping restore that ecosystem. So what I try to do, and Palmer mentioned this, and the last thing is like, how do you get two assholes in a room and get them to agree? Well, it gets extrapolated to like the 10th degree when they're both PhDs.
Starting point is 00:33:45 And so, which is like, in my experience, I don't have a PhD and people think that I have a war on academia at times, but like be pretty hard to deal with people out there or PhDs. In my experience, they actually have a model where I have found those when you sit them down and tell them that they're both right. And you help them walk through that it actually works. And so what I've said is maybe George is right that this level of density of mammoths at this long, at latitude, will have this level of impact. But maybe others are right saying that it will have a positive benefit on the flora and fauna, but it won't cure carbon tree, climate trees. Either way, it doesn't really matter if it's having a net positive benefit
Starting point is 00:34:24 on elephants today as well as the ecosystem of the tundra, which is highly degraded. So everyone can agree that the US system sucks, and we need to make it better, right? And so I've done that. And, you know, I don't know. I don't want to say that George is right, but I'll just say, I've looked at the math, and I think George's pretty smart. Okay. Ben, you just spun out AstroMEC, a multi-billion dollar company from the start.
Starting point is 00:34:51 What is Astromec doing? So we're looking at, so this was kind of a T-F from your question. The foundation models and ad models aren't quite looking. at the entire tree of life, and they're not, like, they're not going to magically overnight give them a genome and give us an answer. So we are trying to build, like, what are kind of inflection, we call them internally inflection models? What are deflection models that can plug into those foundational models that can say, okay, we've studied and we understand everything about this genome sequence across how it's evolved, and more importantly,
Starting point is 00:35:25 when it evolved and why it didn't involve in related clades. And then we're looking at everything from climate, like, what spurred that? Because we want to build essentially a prediction model to say, okay, where did that go and why did it go? Because I don't think that Astromach's going to have the magic, you know, anthropic mythos, you know, $4 trillion or whatever the latest round is, that solves all things always.
Starting point is 00:35:49 But what I do think is I think it'll have enough of the unique data sets in how to classify and understand that data set, that it can plug into those so that when you do have global biovolts and you have millions of samples that you can feed into a mythos. This can be acting like kind of the, or a mythos like competitor, this can be acting as like your traffic control cop of where to go and where to focus. Yeah, yeah.
Starting point is 00:36:10 Let me synthesize a couple of questions here. What's the biggest problem you wish people we're working on, the biggest moonshot that people are not right now? I think that the, we are going to lose half of biodiversity in the next 25 years. And everyone who loves us and hates us agrees with that. So we need to do something about it. Governments, like this is not going to be solved by a zoo or a nonprofit. We have to have billions of dollars of federal funding across multiple governments
Starting point is 00:36:41 working together to at least back up life. We back up everything else. We back up our, you know, we back up our photos. We back up our texts, our emails. We back up everything. But ultimately, I think most people back up their text and emails. But some people do signal. But like for the most part, though, I really think that we have got to right now invest in infrastructure to back those species up.
Starting point is 00:37:07 Because if you don't like, when we lose those species, we're going to have negative impacts on ecosystems. When we lose those species, we're going to have negative impacts in the food web for the animals. But so if you like ecosystems, you should back it up. If you don't like ecosystems and you hate the environment, but you like animals, you should back it up. If you hate the environment and animals, but you like fucking humans, you should back it up. Because there's data in there that will help humanity. Just as a quick aside, one of my companies with an amazing CEO, Bob Hurray, called Cellularity, we have something called Life Bank USA that when your baby is born, you store all the placental cells.
Starting point is 00:37:45 And you've got basically the original boot desk. You've got your kids, stem cells, T cells, natural killer cells, everything. And it's like if your baby came with an extra set of organs, would you throw them away? Probably not. But why throw away? You know, the placenta is the 3D printer that creates the baby. So, I mean, this kind of envisioning of safety of backups is amazing. So this is what you're doing right now in Dubai?
Starting point is 00:38:13 We're doing it in Dubai. We just announced a partnership with U.S. Fish and Wildlife here as part of Secretary of Interior's directive on backing up the natural resources that make America great. So we're doing that now here domestically. We have two other governments. We haven't announced yet that will announce when they want to announce that are part of our framework. And then it's also kind of like what George and I also talk about
Starting point is 00:38:38 with Open Source, it's completely open. So any nonprofit, any academic institution, any big foundation, any private individuals to anybody in Palmer's Secret billionaire Boys Club that wants to throw a money at this. Everyone wants him to B-Boys. Are you in the B-Boys? So, so the, anybody that like, wants to say, I'm not in these secret chat groups. I have a quick question.
Starting point is 00:39:01 All right. Let's close it out with your quick question. I want to be Ben Lamb with the mind as creative and crazy as yours to envision these things. How do I go about doing that? Oh, how you do what? How do I go about? How did you become? How do I become a take on the mindsets that you have to apply technology as incredibly
Starting point is 00:39:22 creatively as you have done. So, well, it's very kind. I think that I'm very curious, right? So I like to just learn new things. And I think in a world, especially with AI, where everyone's got every answer to their tool, at their fingertips, I'm pretty good at telling people what I don't know.
Starting point is 00:39:39 So I think I kind of take a childlike wonder to things and just say, hey, I don't know this, but I'm sure I could go find the answer. And what I've also found, which most people, this is big advice that I'd also give everyone, people will help you. Like, I am an optimist. I believe in technology,
Starting point is 00:39:55 but I believe in humanity first, and people will help you. So, like, I don't think people ask for help enough. I think everyone's, like, walking and on subways and shit, looking at their phones, but if you just look out for a second and ask for help, people will help you.
Starting point is 00:40:08 And so it's like, when I don't understand something, sometimes I will call people in this, like some of our top advisors at Colossil are advisors, because I just called email them, like, hey, I don't understand this, my teams are telling me this, you're the world's expert. this, can you have a meeting with me?
Starting point is 00:40:22 They have no, this woman or man has no reason to talk to me, right? But they'll take the call. And so I feel like I just have this general curiosity wrapped with. People like you. They want to help you. I think they'll like everybody. Like I really do. I think you can just, if people ask for help, nine out of ten times,
Starting point is 00:40:38 I believe in humanity, they will help you. A big, a quick, give it up for that, right? A curiosity mindset, a purpose-driven mindset, and a quick question from Kathy Wood backstage. who said yesterday Anthropic, you know, set up their, announced their wet labs
Starting point is 00:40:57 that were able to create something like CRISPR-like, does this light of fire in your work, or does it, you know, kill forward momentum? So how- I think it's massively validating, right? Like, it's a great question, Kathy's great. I think it's really important, right? Like, there are so many problems to solve in biology. These technologies are, we are just,
Starting point is 00:41:17 like, we haven't even opened the door, like, the door's barely, barely, barely, I think that what they announced yesterday, like people see that and say, oh my gosh, biotex is going to be dead because it should be anthropic in their lives. That's not true, right? That's just not true. And so I think that that was a huge watershed moment for the industry to show that, like, you have the AI companies that understand, and yes, Dario's background in biology, but you
Starting point is 00:41:39 have the AI companies that understand that that will be one of the most accepted use cases in deployments of their technology and that people want to have healthier families, healthier, longer lives, right? So it was a great thing for this society. Really short. Do you have a P-Doom or do you not even think about the question? I'm an optimist. Like, I'm an optimist. Like, I don't agree with, you know, I think we're going to have some scary moments. And I think that's okay, right? Because I do believe in human ingenuity to work through those problems, right? But I think that you've got to have a conversation. I do think that the media is overselling that a little bit right now to be kind.
Starting point is 00:42:24 But I do think that, like, you know, we really will get there. And we're going to have a couple scary moments. But it's like you have turbulence on planes and everyone still lands, right? Like, that's okay. All right, welcome to the Oscars of optimism. Give it up for Ben Lamb. Okay. When I sell my business, I want the best tax and investment advice.
Starting point is 00:42:45 I want to help my kids. and I want to give back to the community. Ooh, then it's the vacation of a lifetime. I wonder if my out of office has a forever setting. An IG Private Wealth Advisor creates the clarity you need with plans that harmonize your business, your family, and your dreams. Get financial advice that puts you at the center. Find your advisor at IGPrivatewealth.com.

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