Ologies with Alie Ward - Emmenology (MENOPAUSE & PERIMENOPAUSE) Part 1 with Monica Christmas, Mary Claire Haver and Lara Durgavich

Episode Date: July 15, 2026

Hormones. Mood swings. Brain fog. Night sweats. And why doesn’t your shoulder work? The time is here for this whopper of a 3-part series on menopause with a total of five Ologists. No matter what yo...ur age or gender, you owe it to the people in your life who go through this to understand it. Brilliant and charming Dr. Mary Claire Haver is an OB-GYN who wrote bestsellers “The New Menopause” and the just-released “The New Perimenopause” and hosts the podcast unPAUSED. The wonderful and warm Dr. Monica Christmas is a professor and clinician with decades of experience in menopause treatment,  and repeat guest Dr. Lara Durgavich is a primatologist who has some answers about why our species goes through “the change.”  Part 2 covers what to DO about symptoms of menopause, from vagina creams to hormone replacement therapy to libido to brain clarity and the importance of lifting heavy stuff.  And finally, Part 3 has advice for loved ones to help support people in their lives who are sailing the stormy seas of hormonal change.  Browse Dr. Christmas’s papers on ResearchGate and follow her on Instagram Visit Dr. Haver’s website and follow her on Instagram, YouTube, TikTok, and Substack Buy Dr. Haver’s books, The New Menopause and The New Perimenopause Follow Dr. Durgavich on Bluesky Donations went to the Center for Food Equity in Medicine and St. Jude Children’s Research Hospital More episode sources and links Other episodes you may enjoy: Gynecology (NETHER HEALTH), Urology (CROTCH PARTS), Biogerontology (AGING), Sexology (SEX), Neuroendocrinology (SEX & GENDER), Biological Anthropology (SEXY APES), Evolutionary Anthropology (METABOLISM), Thermophysiology (BODY HEAT), Somnology (SLEEP), Mnemonology (MEMORY), Attention-Deficit Neuropsychology (ADHD), Molecular Neurobiology (BRAIN CHEMICALS), FIELD TRIP: Alie’s Mystery Surgery 400+ Ologies episodes sorted by topic Smologies (short, classroom-safe) episodes Sponsors of Ologies Transcripts and bleeped episodes Become a patron of Ologies for as little as a buck a month OlogiesMerch.com has hats, shirts, hoodies, totes! Follow Ologies on Instagram and Bluesky Follow Alie Ward on Instagram and TikTok Editing by Mercedes Maitland of Maitland Audio Productions and Jake Chaffee Managing Director: Susan Hale Scheduling Producer: Noel Dilworth Transcripts by Aveline Malek  Website by Kelly R. Dwyer Theme song by Nick Thorburn Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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Starting point is 00:00:00 Oh, hey, it's that Band-Aid floating in the public pool. Don't worry about it. Allie Ward. And I have been promising you this episode for seven years. So don't say that I never gave you anything. It just took a minute. Because this one is a three-parter. Technically, five guests. Just an embarrassment of riches when it comes to information and also guests. So Eminology, it's a study of menstruation, apparently, and it's related disorders. And this episode, we will get to what's natural and other primates. symptoms, tests, the latest research. And this one is also for people assigned male at birth for partners and kids and coworkers of people experiencing paramedopause and menopause. Because if you don't have info about it, your relationships will 100% be impacted. Also, don't call yourself
Starting point is 00:00:51 an ally or like a feminist or someone who believes in gender affirming care and then skip this one because it's about menopause. So I'm glad we're all here. Also, a note up top. Trans men can go through menopause. Non-binary people can go through menopause. Not all women have uteruses, myself included. Many times you will hear the words female or women in terms of describing a patient and just know that refers to the majority, but not the entirety of gender identities going through this. And we have an awesome episode of Dr. Daniel Fow called neuroendocrinology. It talks a lot about hormones and the brain and gender. We'll link that in the show notes too. But before we go further, let's say a quick thank you to patrons of Ologies who are signed up for a dollar or more
Starting point is 00:01:33 a month via patreon.com slash Ologies and who submit questions that helps steer the show so much. Next week's part two will be wall-to-wall your questions. Also, if you do have kids, heads-up, we have a spin-off podcast called Smologies. You can find it anywhere you get podcasts. Just search for S-M-O-L-O-G-I-E-S. No swears in that one. If you want to find other ologites in the wild, we have merch at Ologiesmerch.com. For $0, you can help us out tremendously. just by leaving a little review. I read them all for real. And to prove it, thank you Fassie 1900, who called Ologies, education without the boring, polite part. And to Ben Frye 14, who changed their major because of Ologies, thank you, Ben Fry 14, for being an environmental toxicologist.
Starting point is 00:02:15 I wish we didn't need you so much. But hey, also, people always say, just pick an episode at random because they're all kind of weirder than you think. So for a complete list of all 500-plus episodes, you can go to Ologies.com. We have a sorted menu there. And every, episode we donate to causes of the ologist choosing, thanks to sponsors of ologies. Okay, Eminology comes from the Greek for monthly, and this week in part one, we're covering the symptoms and the biology and the cognitive effects and hot flashes and diagnostic tests and firsthand perspectives of two OBGYNs who actually went through it, and next week, it's all about what to do about it. What do you do? Hormones.
Starting point is 00:02:58 No hormones, how to deal with brain fog. What do you do or what can you take for the feelings of mood swings or depression, how to get better sleep, what to put on your vagina, making whoopee with gusto again, and why you should think about your skeleton now. Like now. That's all going to be next week. What do you do? So this week we have one ologist, Dr. Monica Christmas. Monica Christmas, she her. An associate professor of obstetrics and gynecology and the director of both the menopause program and the Center for Women's Integrated Health at the University of Chicago.
Starting point is 00:03:31 We also have on Dr. Mary Claire Haver. Dr. Mary Claire Haver, she, her, who is a longtime health care provider in obstetrics and gynecology and a well-known advocate in this space. She authored the New York Times bestselling books, the new paramedopause book, and the New York Times bestseller,
Starting point is 00:03:49 also the new menopause book. And she hosts the podcast Unposed. And for this part one, we also have a message to you from Dr. Lara Durgovich, who is a visiting lecturer at Boston University's Department of Anthropology, and she shares why we, as apes, why our bodies even bother with menopause, where are they doing it, and how researchers study it and what we can potentially infer from orangutans going through a change of life. So take my hand.
Starting point is 00:04:17 Let's dive in with some of the most experienced ologists on this planet about this, Dr. Haver, Dr. Christmas, and Dr. Durkovich, all of whom are excellent Eminem. You have been on our list for a really, really long time. And every single week when we check in in our meeting, we go, have you heard from Dr. Christmas? Oh my gosh. Do we hear back? And so we're all like, wow. Yeah, we've been talking about you for months. So today is a big day for our whole team. You're a celebrity, Dr. Christmas. You get asked about that every single day, don't you? People ask me, what does it mean? I'm like, I don't really know. It's my married name and I'm a divorce person now. But the patients like it, especially during the holiday season. So it got me into a lot of
Starting point is 00:05:24 trouble, though. I had my maiden name through medical school, but I changed it onto my married name right before residency. And it was not fair because everybody could remember Christmas. So I got called on all the time. And I would say that to my colleagues. Oh, you're exaggerating. I get called on too. And then I was out for like vacation one week and one of my co-residents called and was like, yeah, Christmas, you're right. They are just calling on you because you got called on like 10 times today and we kept saying she's not here. So I was like, I told you, I told you that I was unfairly being targeted. Like no one ever forgets. I'm sure. Right. I was like, I've asked more questions. I am. Well, that's probably why you're so good at what you. It's almost like you got one-on-one tutoring and so much one-on-one attention. And I know that you give very good attention to your patients. You have a very holistic approach from what I understand. A lot of people I hear from, they're like, my doctor doesn't even know what's going on. What was it about gynecological health and obstetrics and menopause that kind of attracted you to this? Well, the menopause stuff kind of fell into my lap serendipitously, which is always
Starting point is 00:06:39 the best way for things to come your way, because that means the universe conspires for good. But my first job out of residency, I worked with two fabulous doctors. They're really great guys. And they were great obstetricians. I mean, they were gynecologists too. But they had a really big obstetrical following. Women came to them. So when I first started with them, like, I didn't have any patients really. I mean, because all of the pregnant patients, and saw them. So what I was left with was a lot of women that were going through this midlife transition and not going to claim that I knew everything. But what they really loved is that, one, I had a lot of time. I had a lot of time because I didn't have any patients. So I could spend
Starting point is 00:07:24 an hour or more just shooting the breeze listening to them. And then I would call them back later that day, which they loved like, oh my gosh, my doctor, she's so sweet. She called me at home. And I tell them, well, these are the options that we could try. And if this doesn't work, we could do this next thing. And so before I knew it, they had told all the people at the train stop or at the water cooler at work that they met this nice, great young doctor. And she's so good. She just really listened. Little did they know, like, all I had to do was listen.
Starting point is 00:07:57 I had all this time. But anyways, I built this patient following. And a lot of midlife women, too, have issues with bleeding. and sometimes it was fibroid related or adenomyosis or, you know, a hosted things. And so then I had a big surgical patient population too. And it turned out that I really love surgery and I really loved taking care of women or helping them traverse through this thrive, I should say, thrive through the menopause transition. And my mom was also going through menopause at the same time and having a horrible time of it.
Starting point is 00:08:32 But like I'm having these issues and what does. this mean and, you know, is it my thyroid? Is it this? Is it that? And sometimes it's all of the above. But that's the thing is that menopause happens at a time when we are aging. And when I say everything isn't just menopause, I mean everything isn't just due to your ovaries not making the reproductive hormones anymore. It is very difficult to sometimes disentangle, which truly due to chronological aging versus what is actually due to menopause. And there's not one menopause syndrome that every single person gets. Some people have very few symptoms, if any at all, and then there are other people that have everything under the sun. So, you know, it's important
Starting point is 00:09:13 not to unnecessarily scare people and think that this horrible thing is going to happen to you, you know, because that's not true either. And I think we are creating a sense of hysteria for people now that shouldn't happen. Hysteria, side note, comes from the Greek word meaning uterus, and hysteria was a condition thought to be caused by a wandering womb that was an animal living inside your body, just sauntering around and lured to and fro by pleasant smells or stomping around angry because it's lack of a child inside. You're like, okay, dude, sounds pretty solid. But interestingly enough, actually, there's a very real condition endometriosis caused by uterine-like tissue that just up and grows anywhere in the body.
Starting point is 00:10:04 Can grow in the bowels or the pelvis, sometimes a lung or the brain. And thousands of years after our boys in Togas were contemplating an entity wandering about the cabin, we still don't have any readily available tests or good answers for this excruciatingly painful and debilitating condition of endometriosis, which on average takes seven to 10 years of pain to diagnose.
Starting point is 00:10:30 if it's ever clocked by a doctor, not to get hysterical about it. But yes, menopause. That's such a good point off the bat because I know that it looms for some people. It's like, when is this thing going to hit me? Like a specter, like a hormonal goblin waiting to pounce. And, you know, I'm wondering for you personally, because you started out, obviously such like a young, inquisitive and hardworking doctor. I don't, you're probably not at that age yet.
Starting point is 00:10:58 But as you age, are you like looking out? for those types of signs? Oh no, I'm in my mid-50s and I'm menopausal. So, you don't look like it. Oh, bless your heart. No, you didn't. I thought you were much younger than I am. I happen to have gone through it in my mid-30s. I have POI, so like didn't know what was going on. So now my friends are starting to go through it. And I'm like, done that. But I'm also the friend that they're like hormone patches. What do you use? But I'm wondering how do you, for you, going through it. Has it changed at all? Having experienced things for San, like, do you feel like you're more keyed into seeing these symptoms on a smaller detail? You know, it's always different when
Starting point is 00:11:41 it's yourself, too. I started to experience menopause-related symptoms really early to earlier than the natural you mentioned premature ovarian insufficiency. And so I remember being like, oh my goodness, waking up with night sweats and I thought I had tuberculosis. Right. Yes, I'm only whatever age. Like, I've got TB. You know, when you're a healthcare professional, you can give yourself all kinds of bad diagnosis and you go to the extreme.
Starting point is 00:12:11 It doesn't necessarily make you smarter. You know, so I'm like, oh, my God, I have TV. You know, who coughed on me? Yeah. I don't have TV. Yeah. But of course, you're not expecting it at a younger age, but. No, then the other funny, when you're.
Starting point is 00:12:28 don't think it's you too, is that, so I have frozen shoulder and both my shoulders, right? And I love Pilates and yoga. And if there was ever a fountain of youth, it's actually not hormone therapy. It's probably Pilates or yoga, I would say. But I think I'm in shape. You know, that's my life savor or whatever exercise. But so anyway, started having this pain initially is on the right shoulder. And it got really bad, though. Like I couldn't get my arm in and out of a jacket, let alone, I wasn't wearing any dress that had a zipper in the back because I couldn't get my arm around the zip. I'd roll over a certain way in bed, it hurt. And so I was convinced that, like, again, with the TV diagnosed, self-diagnosis, I was convinced I'd, like, torn my labrum or something,
Starting point is 00:13:13 you know, like, I'm so dramatic. And so I went to, like, an ortho colleague of mine and got the million-dollar work up and he comes in the room. He's much younger than me, too. And he sits down and he says, Well, you know, Dr. Christmas, women of a certain age, immediately I was like, all right, if that's all it is, I'm fine with it. But I thought this was much worse than I thought a frozen shoulder could be. So that did make me more sympathetic to the patients that came in with joint pain. And I don't have a fix for it. Frozen what now? Yeah, frozen shoulder.
Starting point is 00:13:53 You can call it also adhesive capsulitis if you want. If you're screaming, this can happen into your potting soil or your windshield right now, yes, it can. News to me. And according to a very recent paper, frozen shoulder, diagnostics and treatment of adhesive capsulitis in the American Journal of Medicine, corticosteroid injection and physical therapy can provide meaningful benefit in appropriately selected patients, while surgical intervention is reserved for the tougher cases. What else can work? Why? So hormone replacement therapy could. Newer research is suggesting that estrogen is protective against inflammation and fibrosis of tissues. And the small Duke University study found that the prevalence of frozen shoulder was about half of that in the group on hormonal replacement therapy. But again, small sample size, more research is needed if they can get the funding. But Dr. Christmas afflicted and helping those afflicted, sees clinically that some people will respond to hormone therapy in cases of the
Starting point is 00:15:01 frozen shoulder, but the vast majority of people don't. Some people will respond to hormone therapy, but the vast majority of people don't. And so, you know, people will come in and they'll say, great, my hot flashes and nights sweats are gone. I'm sleeping much better. But I still have this terrible joint pain. Or in my pace, I still have shoulder pain. And I'm like, yeah, but I never told you it was going to fix that. There's only so much it can do. You're like doctor. heal themselves. Especially when you're like, I'm an athlete, okay? I'm an athlete. This is from yoga. Right. Speaking of athletes, we do have a whole team of experts for this three-part episode. So let's meet Dr. Mary Claire Haver, author of The New Metapause and the New Peri Menopause,
Starting point is 00:15:45 globally known advocate for menopausal awareness, who communicates a lot on the topics of hormone replacement and increased research for women's health and the role that physical activity can play and staying healthy. So let's roll back a little. Let's learn more about her. You know, from your book, I know that you were doing a lot of reproductive care, a lot of care for women and other people with uterces, and it wasn't until you went through some hormonal changes yourself that you're like, oh, shit, what? Yeah. I wish I could tell you that, you know, I noticed the patterns from my first day of clinical practice that, you know, women after reproduction in were getting the shaft. But no, no, I was a horrible menopause doctor for probably 15 years. And I was aging along with,
Starting point is 00:16:32 so I didn't have that many menopausalish patients because when you start out, you get all the OB patients. Yeah. And I was having babies with them. So I'm aging along with my patients. So, you know, it took 10 to 15 years for me to start going, huh, I run with this woman. We've run marathons together. We do book club. Like, she's not lying. I know what she eats. I know how much she exercises. Like this weight gain stuff, her brain fog, like, this is real. Then the divorces started happening in our friend group and all around the same. And I'm like, you see people's resilience start crumbling when you watch the lives that they built and they were managing everything, the ups and downs, the stressors. And then all of a sudden they've just like, hit a wall. So those were really when I was like, something is not right. And then it was happening to me, too, of course. Do you feel like you're people's frontline person for questions about menopause like more so than their own doctors? Yeah. And that's okay. I don't mind it. What kind of freaks me out is I've been doing this 10 years and I get the same questions
Starting point is 00:17:40 every day. Really? Yeah. Really. Okay. Let's launch into them. Just rattle off. Like what are some of the most common ones that people have. I mean, I now get thousands of DMs a day and we can't answer them, right? But just the most basic stuff, like, is it okay for me to be on hormone therapy? Is it safe? Am I in menopause if I have X, Y, and Z? Just, I'm like, wow, it's crazy to me that, gosh, there's still women out there who aren't getting access to the basics. So for sure. So let's start with those basics to save your sanity and also your bones and your heart. So the best way I can explain it is in a pre-menopausal woman, before menopause enters the chat or perimenopause, you know, females are born with their entire egg supply.
Starting point is 00:18:28 Males make their stuff fresh every day. So big difference between the testicles and the ovaries. The ovaries are just waiting for instruction. They don't actually do anything on their own. The instructions come from the brain. So we have two glands in the brain, the hypothalamus and pituitaries. The hypothalamus is basically looking for estrogen. Okay, where is it? Where is it? Where is it? When it runs low naturally in a normal cycle,
Starting point is 00:18:48 it starts saying, hey, we want those estrogen levels back. Come on. So it starts sending signals from the hypothalamus to the pituitary, then the pituitary pumps out FSAH and LH that go and bind to the cells around the eggs. And those cells, the follicular and granulosis cells around the egg are where the sex hormones are made. I'm simplifying a very complicated process. So when you look at LH-F-SH-H, estrogen, and progesterone in a healthy woman who has regular cycles, right? You at 23, I'm assuming, you have this very predictable ebb and flow, EKG-like, month after month after month, of day 12, you're going to do this. Day 14, you're going to do the outside of starvation, pregnancy, heavy exercise, stress, you know, that process is meant to
Starting point is 00:19:30 happen month after month after month. Until we reach a critical egg threshold level, which you met very young. Something destroyed the eggs, autoimmune disease, usually, in your body, before they would have run out on their own. And that's what POI is. And so we reach this critical threshold. With the signals coming from the brain, the ovaries become resistant. And they don't work as well. Okay, there's not enough eggs to respond.
Starting point is 00:19:57 So the brain starts flipping out. Like, where's my estrogen? Start pummeling the pituitary. Give me more, give me more. We get these much higher levels of pulsatol, LH and FSAH, to force those few last, you know, the eggs remaining to make the ovulation happen. And sometimes we have these loop ovulations where we have two back-to-back with no break. So we end up getting a very sporadic, much higher than outside of pregnancy.
Starting point is 00:20:22 So we'll get estradiol levels, sometimes three, 400 like pregnancy levels, like early pregnancy levels. Well, and then we get these crashes, and progesterone never keeps up. So what used to look like EKG predictability now becomes chaos, which is why we call it the zone of chaos. We've known this since 1996. That paper came out in 1996. I'd never heard of it. Oh, the rage. The flames on the side of my face.
Starting point is 00:20:47 Flames. Flames on the side of my face. Breathing breath. Until 2023. Insane. And I'm reading this paper and I'm like, what the fuck? Yeah. So all of that chaos of our hormone levels, our neurotransmitters are affected, our estrogen receptors and where they're located, we upregulate in certain areas.
Starting point is 00:21:11 how we process glucose in the brain, the amygdala that controls our emotional centers, the frontal lobe where memories are consolidated, all of that takes the hit, the brain stem, how we sleep, cortisol, stress. Like, it all becomes this whirling dervish. So perimenopause is the brain. And so brain fog, mental health changes, anxiety and depression, rage, and sleep disruption. That is the beginning of perimenopause. Not cycle. Psycho disruptions are at the end for most women. Oh, my God. Oh, Oh, dear Lord, there's so much to learn. Okay, so let's talk timing. Let's talk symptoms. If you're not me with a wonky early condition, Dr. Christmas lays it out. And what is natural menopause?
Starting point is 00:21:52 The median age is about 51.5, 52. The range that 95% of people fall into is between the ages of 45 and 55. And we start to experience symptoms related to hormonal fluctuations up to four to seven years beforehand. So it is actually true that potentially for some people in their late 30s or early 40s, you might start to have some symptoms. The first symptom is usually changes to your menstrual cycle. So if your cycles are changing by more than seven days consistently, not a one-off, but consistently that's the early perimenopause phase. And once you start skipping more than 60 days consistently, that is the late perimenopause. And then do you cross that sort of checkered flag? when it's been a year since you've had a period or is there a certain amount of time where it's like,
Starting point is 00:22:41 okay, it's definitely, it's jigs up. Yeah, it's a full year. And it's retrospective because you don't know when you're having the last menstrual cycle. In fact, Mother Nature has a very cruel sense of humor. And people can go many months without having a period. They give all of their protective things away. And they're like, I'm here. And then they'll get like a last hurrah or two. So that part of it. really burns me up because it's like, why don't it just stop? Like, why don't it have to do that? Just stop. Yeah. Nobody asked for an encore. No, nobody did. It's not fair at all. Hey, heads up, perimenopause can last between two to 14 years. And even though your egg supply might be diminishing, it only takes one egg to get pregnant, folks. And when I didn't know what was happening
Starting point is 00:23:28 in my 30s, my period took a little hike, took a hiatus. It's like gone fishing for a bit. And I thought, what if there's a uterus intruder in there? Is that why I don't have my period? And I was forced to go to a Walmart where I bought a di-a-doctor-peper in a pregnancy test. And the weird thing about buying a pregnancy test when you're in your 30s is like the cashier who was a younger woman. She gave me a really encouraging, good luck as I left. And readers, I did not want a child. But I peed on it in a nearby gas station bathroom. Surprise. It was just menopause. And it was thankfully negative. if you're not looking to cultivate anything in your uterus at the moment, and you're like, I should be fine.
Starting point is 00:24:11 I'm like having hot flashes. I'm sorry, babe. Do not be the victim of a cruel hormonal joke where the punchline has two blue lines. One of my favorite things to do during perimenopause, though, is to use either continuous hormonal birth control or put in a progestin IUD because it helps to kind of cheat our way through that erratic bleeding. Because even if your periods get shorter, lighter, and they start to space out and then politely go away, it's still, if you don't know when it's going to come, that can be extremely anxiety provoking for some people not knowing. I mean, it would be for me. So if you think that answering a call from an unknown number is daunting, I invite you to wear an outfit you like and then just roll the dice on spotting blood. I've always said that death is like wearing white jeans when your period is about to start. Just gnawing anxiety. a reminder that to be alive is to lack control. When it comes to those symptoms, what are some
Starting point is 00:25:09 hallmarks to look for? Let's go through the physical symptoms that your patients come in with that you're like, obviously hot flashes. Do those last like 10 minutes? Do they happen at night more? Dr. Christmas explains. So let's look up the history of perimenopause because that's not typically something that people have always talked about. Like you talk about the menopause. So anyways, I found this stuff, this doctor in 1867, he kept a diary or chronological notes of all of his perimenopausal women. And so to answer your question, I was trying to find it because I was going to rattle off the 22 symptoms that they did. And I loved how they described some of them, too. So that's why I was looking for the little paper. And of course, as I'm sure you know, this was the 1857 paper
Starting point is 00:25:53 of Dr. Edward John Tilt titled, A Clinical Treatise on the Diseases of the Gingleonic Nervous System Incidental to Women at the decline. of life, and he comes in hot in paragraph one, stating that some German doctors call this, quote, the period of sexual involution. And he only slightly, more softly, notes that his female patients have called perimenopause the dodging time. Now, the table of contents in this book includes some real whoppers of anachronisms, as he describes patients who have experienced delirium caused by cessation. Insanity. occurring at the change of life, fits and eruptions of the face caused by the change of life,
Starting point is 00:26:38 successive fits of coma at the menstrual periods, hysteria caused by cessation, short and sudden fits of the impossibility of speaking after sensation, and plainly melancholia. But considering the period, if you will, he seemed to at least be a doctor who gave a shit. Because in chapter two, he writes, the ovarian influence reaches the ganglionic center, which is in constant communication with the brain. So at the change of life, its undue influence is shown by distressing headaches, continued fretfulness, peevishness, and capriciousness called temper by a temporary perversion of moral feeling or by moral insanity. The disturbance is on the mental faculties, which are for a time in a state of misty haziness. The brain feels muddled. Memory is faithless. There is an memory is
Starting point is 00:27:33 faithless and there is an incongerable desire to sleep during the day. Even when the night has been passed in repose, he concludes, having thus briefly sketched the varied phenomena, I am able to open the investigation of its terminal crisis. So yes, a person can feel like garbage in so many And we've known that for years, but society at large has neglected to care. At any rate, about 80% of people will have like some sort of vaso motor symptoms, hot flashes, night sweats, some people will say, I don't necessarily feel hot, but I get these cold, like, feelings too. So, you know, however you describe it, but it's usually kind of feeling like you're on fire from the nipple line up. And then it's quickly as you feel warm and it can come out of
Starting point is 00:28:21 nowhere. You start to cool off and then people sweat and then you feel really cold and shivering after that because you're wet from the sweat. So these are called the vasomotor symptoms. And according to the JAMA article, duration of menopausal vasomotor symptoms over the menopause transition, they usually last between a minute to five minutes at a time. And up to 80% of people going through paramenopause have them. Those are pretty high odds. What else do you look for? Dr. Christmas continues. The mood symptoms, and they can swing from having depressed mood to anxiety to anhedonia, that not having the energy or the, you know, just the motivation to do things that were much easier
Starting point is 00:29:09 for you to do. People will talk about sexual dysfunction, decrease libido. Sometimes it's tied to vaginal dryness that could contribute to pain with intercourse, but sometimes people are like, no, I don't have any pain. I'm not dry. I just don't have desire for sex. And it happened pretty abruptly for me. The joint pain that I already talked about, me and my frozen shoulders, skin changes, hair thinning, maybe having acne when you never had acne issues before. A big one, huge one. I should have put this right underneath vasomotor symptoms. And maybe for some people, it should have been above that as weight gain. And it can seem like it happened overnight. Like I woke up and I was 20 pounds heavier. It's probably not necessarily a menopause related thing,
Starting point is 00:29:55 but an aging thing, but we do notice it. It can be pretty pronounced like the couple of years before the last menstrual period and a couple of years after the menstrual period. So there's about a five-year window where people notice this like if you're not doing something about it, even 20 to 30 pound weight gain that can be extremely distrustful. And people, I'm not eating any differently. I'm not changing anything with my exercise habits. And I say, I get it. But we have to. We have to put in a little bit more effort because as we get older, we're losing muscle. That muscle is replaced by fatty tissue. Much of that fat deposits in the midsection from a vanity perspective, that's a horrible place for it to go. From a health perspective, it is too. So really
Starting point is 00:30:36 counseling people about the importance of regular exercise, including weight-bearing exercise, is really important. So this, again, this was news to me, but if it seems like your body composition is changing, but your diet hasn't. There are a few factors. So without enough regular physical activity, especially weight-bearing exercise, women tend to lose up to 8% of their muscle mass per decade. That's a lot. And less muscle mass means a lower resting metabolic rate, which leads to increased fat stores on the same diet. So low estrogen also directs that adipose tissue to just hang out and just kick it in the midsection, which can also lead to heart disease and further metabolic disruptions. So muscle mass really matters here. Also good for the bones. We'll talk about that later.
Starting point is 00:31:28 But if your sleep sucks also or your stress levels are high, that can contribute to changes in your metabolic rates and eating patterns and thus body composition. And again, in part two next week, we're going to go over how that impacts your skeleton, why that should matter a lot to you, your risks later in life, and we talked to a researcher from Smith College, Dr. Sarah Wutkowski, all about the overlooked risks to heart health and menopause, and she will inspire you to just go out into the guard and start lifting logs while screaming at the sky. You got to wear gloves, though, no splinters. Overall, some people just say, I just don't feel like myself. I don't know how to put my finger on it, but I just don't, I don't feel as confident. I've got this brain fog.
Starting point is 00:32:10 Does that mean I'm going to have dementia? It does not mean you're going to have dementia. You know, I just have difficulty recalling things. I just don't think that I'm functioning like I normally do. And in my work setting, I just don't feel like I'm doing it as well. So I don't think I forgot anything. That was a lot, right? No, yeah. I mean, and there's, I'm sure so many more. The brain fog stuff is really interesting. And we had so many listeners to ask about that. And I remember when I was going through, you know, my ovarian failure, I also thought I had early, early onset dementia. I like wrote down my address wrong. I remember I was in a family reunion and I could not remember my cousin's name. I was introducing her to my husband and I was like, and I'm like just blank where you're like Swiss cheese. Some people ask too, their ADHD seems to get a lot worse with a drop in estrogen. So any idea why that brain fog and how those cognitive effects happen? Yeah, Dr. Polly Mackey has done a lot of work in that area. There does seem to be some brain changes, especially.
Starting point is 00:33:14 and our white matter densities with decrease in estrogen. But that doesn't necessarily mean that you're going to have dementia either. And it's hard to say if that's what causes kind of the concentration focus issues and the brain bog name recall. Interestingly, if your night sweats are keeping you up at night and you didn't sleep as well because you keep waking up frequently with the nights what, if I give you hormone therapy or any of the other non-hormone therapy modalities, and there's some good ones to get rid of your night sweats,
Starting point is 00:33:42 you'll sleep better, then you'll probably feel more energetic. You may think better. So it's not necessarily that the treatment directly impacted the brain fog, but it might have gotten better because we manage these other things that might be contributing. You know, I have to remind people a lot to be kind and gentle with themselves too. Like at this stage, too, we've got a lot that we're doing. You know, they don't call it the sandwich generation for nothing. So as frustrating as it is to have perimenopause dismissed is like, it's just stress that's in your head. It's also not helpful to consider that all of your stress is just caused by hormonal shifts. Sometimes it really is just because things are hard. But if you have sudden pains, like in your lower right abdomen, that could straight up be
Starting point is 00:34:26 appendicitis and not hormones. Chest pain, keep an eye on for cardiac symptoms. And if you've been feeling depressed or especially anxious, no matter what the cause could be, talk to a doctor and see if medication might be helpful. Paroxetine is an antidepressant that the FDA approved to treat phasomotor symptoms in menopause. Some clinicians also prescribe SNRIs or other SSRIs for physical and the psychological effects of hormone changes. And Dr. Christmas mentioned Dr. Pauline Mackie's work. And in a 2022 paper titled Brain Fog and Menopause, a health care professionals guide for decision-making and counseling on cognition. It kicked down a definition for us on brain fog. given that the topic itself is murky and ephemeral. And the paper says that brain fog most frequently
Starting point is 00:35:15 manifests in memory and attention difficulties. And it involves such symptoms as difficulty encoding and recalling words, names, stories or numbers, difficulty maintaining a train of thought, distractibility, forgetting intentions, like the reason for coming into a specific room, and difficulty switching between tasks. And if that sounds like, oh wait, I've had ADHD on my life, Welcome. There's a lot of you. According to the 2024 frontiers and neuroscience paper, the impact of estradile on serotonin, glutamate, and dopamine systems. Estradial functions as a neuroactive steroid, and it plays a crucial role. It says in modulating neurotransmitter systems, namely those involving serotonin and dopamine and glutamate. That affects learning and memory, reward, and sexual behaviors. But researchers stress, it's not all causal. Estrogen, remember, it affects vasomotor symptoms that interfere with sleep, which can cause brain fog, and not getting enough regular exercise or adding in more habits to reduce midlife stress can also muddle your mind. So you might have to think more holistically, like zoom out a little bit more,
Starting point is 00:36:26 and think of ways that you could support your overall health and mental health. And there have been anecdotal reports that adequate omega-3s and magnesium glycinate supplements can help as well. But again, talk to a doctor. Now, a 2025 journal of the International Society of Sports Nutrition titled Creatine in Women's Health, bridging the gap from menstruation through pregnancy to menopause, notes that creatine supplementation has shown positive effects on muscle strength, exercise, performance, and body composition, particularly when combined with resistance training. And it says additionally, creatine may improve mood and cognitive function,
Starting point is 00:37:03 potentially alleviating symptoms of depression. But surprising no one, it does conclude that data, on parimenopausal women remains limited. So take that with a big grain of creatine. Once again, talk to your doctor. I'm not them. So on that executive function topic, Dr. Haver explains. So brain fog does tend to get better postmenopausal. It's worse in perimenopause. Oof. And I talked to Dr. Russell Barkley, who's an ADHD expert, and he mentioned that you do need estrogen to make dopamine and a lot of people who weren't diagnosed with ADHD or have, had mild cases, it flares. It was masked. Yes, it was massed by high performance and a lot of
Starting point is 00:37:44 internal anxiety, which is so many women go through. But are those levels of estrogen also executive function is impacted by dopamine? Yes. So when we look at 20% of women in the UK quit their jobs in perimenopause and menopause. Wow. Not because they hate their job. Like, if you hit your job, you need to go, but because they feel like they can't function. And the problem with brain fog is we don't measure brain fog. We measure for dementia. Okay. Big difference. Brain fog is I can't find my keys. Dementia is, I don't know what my keys are for. Dementia is severe cognitive, like, inability to function. And brain fog is I can't function at my executive level that I was functioning at before. Yeah. Like the happening's not happening. And we have a really hard time measuring that. It's called subjective cognitive decline. So it's really like you tell me, it's subjective. I'm not able to do the math.
Starting point is 00:38:38 at work or I'm not able to juggle all the balls or do the things. And I know that for your personal experience, a lot of it was massed by you were going through a difficult time caring for a family member who was very ill. And, you know, they call the generation, the sandwich generation where you're still taking care of kids and also your, say your relatives, your parents are getting older. So is a lot of that kind of mixed in the soup of just incredibly high stress and high demand. And then on top of that, you're like, I don't know what's going on below my neck. Yeah. I got a lot of shit going on. So it's like everything hits at once, right, for a lot of us. And so forever, everybody just blamed, oh, you're just stressed out, your parents, your kids,
Starting point is 00:39:20 and like these women are coming in my office going, no, bitch, I built this life. Yeah. And I had it managed. I knew this was coming. You know, like, this is different. We can't just blame stress on this. They're like, I had this managed two months ago. And now we're not managing. So how do you know if it's perimenopause? As you age, you know that the egg supply you were born with is diminishing. That's just life just marching toward the shorter end of it. I'm sorry. But can we get some numbers on this? Is there a test? Dr. Christmas lays it out. And then once we really hit this pivotal point, you would think that the ovaries would slow down, but they almost rev up a little bit. And you start losing, we call it atresia. You start losing more eggs, even at a faster rate. And so that is why during that perimenopause transition especially, it's actually not very useful to get lab values because oftentimes women will have actually higher estrogen levels than you would expect.
Starting point is 00:40:18 That's where those loop cycles come in or people will say I bled for 30 days or more. Or I'll get my period. It'll go away. And then a week later, I started to bleed again. It is because of those spikes in hormone levels too. And it's often the fluctuations during the menopause transition that really contribute to a lot of the tumultuous symptoms that people experience, especially the mood-related symptoms. Once you're in menopause and your ovaries aren't making it anymore at all, it's zilch, zero.
Starting point is 00:40:49 A lot of people feel better. It's not the roller coaster. And so when is it helpful? It's helpful if I have a 25-year-old or a 35-year-old that comes in and they haven't gotten their period and or. or they're experiencing symptoms that we would typically relate to menopause, then I want to know, because that's unusual. Why are you at 35 not getting a period? So I am going to get a whole battery of labs because I want to understand, is this premature menopause, is this polycystic ovarian
Starting point is 00:41:21 disease, is it some other endocrine abnormality? And so that's actually very useful information. If I have somebody that's of the natural age range and they are doing exactly what I expect them to do, then the lab value is really not helpful. It's helpful that they're having symptoms because I want to help them have a better quality of life, but what the value is doesn't matter. And just a fun, this is good news. Side note. Since we chatted just a few weeks back, the journal Lancet published a huge paper titled
Starting point is 00:41:50 Polyendocrine Metabolic Ovarian Syndrome, the new name for polycystic ovary syndrome, a multi-step global consensus process. So PCOS, the big news is finally has a rebrand to PMOS. And this study, which was co-authored by over a dozen top experts in the world, acknowledges that PMOS affects one in eight women, and that the term PCOS is inaccurate because it implies pathological ovarian cysts while it says obscuring the multi-system pathophysiology. So it's like, you got some cysts on your ovaries. Well, really, it's like it's way more than that. It's caused by different stuff. And it says it's not simply a gynecological or ovarian disorder. It's actually underpinned by endocrine disturbances in insulin, and androgens, and neuroendocrine and ovarian hormones. It's the whole system. But getting back into menopause, hormones are fluctuating a lot. Your ovaries
Starting point is 00:42:51 are not, they're not quiet quitting. They make them. known as they pack up their stuff. They're slamming some drawers. They're taking time to sleep between taping up their boxes. They're hiding their desk plants in the breakroom fridge. They're letting the entire department know they are out the door. Now, mine left early, and unbeknownst to me and like at least seven doctors. My symptoms in my early 30s were in fact my bewildered ovaries regrettably giving notice early. What I thought, I thought they were like fevers. Those were just hot flashes arriving a decade early. I had no clue. I had weird cycles. They were getting longer in between. And then the doctors were like, it's simply stress. All these weird, totally menopausal
Starting point is 00:43:40 symptoms I was told were just stress. And couldn't I quit my job in TV and find a rich man to marry? One elderly physician asked me without even proposing to me. I had to mood swings, I had crying jags, I forgot my own address. And when a female doctor finally did a hormone panel four years into this mystery agony, it revealed that my follicle stimulating hormone was jacked through the roof. And this is important. So what that number represents, FSAH, follicle stimulating hormone, is inverse to your ovarian function. So if it's high, your brain is flooring the gas pedal to get the car to move. It's saying like ovaries, hey, hey, hey, hey, where are you? But your ovaries are like, my motor's not going anywhere. So premenopause,
Starting point is 00:44:27 your FSA varies by day, but it's usually between the numbers four and 21. Now, once it's up around 30, it's pretty high, your endocrine system is mash in that gas pedal with FSAH to wake your ovaries up, but they are sleeping perhaps forever. So any FSAH over 30 is typically like a yes for menopause. So knowing my FSAH was helpful, but I didn't have a normal time. timeline because again in my early 30s I had what doctors called primary ovarian insufficiency. My ovaries, they took that personally. And what kind of tests are people requesting versus which are effective? I know for me with POI, they tested my FSAH and it was like 130 or something. God, bless your heart. I was like, yeah. I mean, we know how to diagnose POI fairly well.
Starting point is 00:45:15 Yeah. But like for peri menopause, we don't have a blood test. We don't have a urine, a saliva test. Save your money. Okay. We can diagnose postmenopause. So like your FSAH is above 50 consistently, you're postmenopausal. That's it. Okay. Above 100, faux show. Yeah. You know, like ovaries have left the building.
Starting point is 00:45:31 Eggs have left the building. So because of the chaos, these hormone tests are rarely, rarely diagnostic. So we diagnose perimenopause by guess what? Listening to the patient. Oh. Believing her. Doing blood work to rule out other things like autoimmune disease, hypothyroidism. inflammation, nutritional deficiencies, et cetera. We do a lot of blood work in our clinic.
Starting point is 00:45:54 But we're not like chasing hormones in perimenopause because tomorrow it could be something totally different. We're going to continue just a second, but first we're going to donate to a cause of the ologist choosing in this week. We are splitting it between Dr. Christmas's pick of Center for Food and Equity Medicine, an excellent organization that helps lift the burden of food insecurity off of cancer patients and their care providers. They note that in addition to soaring treatment costs. There's also just a high cost of being present during the hospitalization of a loved one. There's parking. You have to bring your own food or buy your own food. There's lost wages. I can add up quickly so. The Center for Food in Equity Medicine helps out with those costs.
Starting point is 00:46:36 As a fresh food pantry, they distribute meals to immunocompromise people via their grocery brigade. They do much more. And Dr. Haver selected St. Jude's Children's Hospital, which works to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment, and they say consistent with the vision of their founder, Danny Thomas. No child is denied treatment based on race, religion, or a family's ability to pay. An actor Danny Thomas, just side note, was born Amos Muziad Jakub Kairus in Michigan to Lebanese Catholic parents and established St. Jude with money that he made as an actor and a singer. And I never knew that, but it's pretty cool. Okay, so those donations were made possible by sponsor civologies. And let's get back to it with Dr. Haver and why learning about this is important for all genders.
Starting point is 00:47:27 And in the last, you know, 10, 15 years, with social media, have you just seen people who are much more tuned in? Totally. Yeah. Yeah. So I really feel like social media has become the female water cooler. And it is a way for us to share stories and to realize that we have commonalities where we never talked about it before because we didn't have the opportunity. And so someone mentions, you know, her frozen shoulder and that it's in menopause. And like 10,000 people ask me, could my frozen shoulder be related to menopause?
Starting point is 00:47:59 I go dig through the data. I find correlations. I find Jocelyn Wittstein's work and Vonda Wright. And then that video goes viral, you know, millions of views. So with tens of thousands of women in the comments going, oh, my God, this happened to me and no one mentioned it. Where is the research at? You know, I know you're digging through research, but how, well, what? well-funded, is it? How up-to-date is it?
Starting point is 00:48:21 Before or after this administration? Let me be clear. Nobody was doing menopause well. It was a bastard stepchild in the research world. So after the WHO, no one was doing this amazing. Okay. So when we look at women's health, so in 2023, McKenzie came in. The Gates Foundation hired the McKinsey. Kenzie group to look at women's health and funding and spending. The total NIH budget was 43 billion. I may not get the numbers exactly right. So women's health got 10 to 15% of that. Okay, so 85% did not go to women's health. 47 billion, but that's close enough. So yes, roughly 10% of funding goes toward women's health. But hey, did you know that before 1993,
Starting point is 00:49:11 you didn't even have to include a woman, a woman, a woman in your clinical trials? So this 19, 1993 change was called the Revitalization Act. And before it, pharma companies just didn't have to include women while testing for drugs and vaccines and stuff. Too complex, they said, those bodies, we can't figure them out. So it's fine. Again, this was until 1993. And it wasn't mandatory for the U.S. to test automotive safety with crash test dummies with typically female proportions until, do you want to guess what year, ever. It's still not mandatory. Crash tests, car safety, tailored toward taller, heavier male bodies, and as a result, as reported in the recent federal report, sex-based differences in odds of motor vehicle crash injury outcomes. Quote, females had significantly higher odds of injury
Starting point is 00:50:07 than males. Males did not have significantly higher injury odds in any crash models. So women, get in the shaft from so many angles. live or die, eh, don't worry about it. And so many medical trials still are skewed disproportionately toward white people. In the United States, Native American and black women are two to three times more likely to die from a pregnancy-related cause than white people. And according to this 2024 McKinsey report, closing the women's health gap, a $1 trillion opportunity to improve lives and economies. Menopause is an area of highly unmet needs. globally. It says it's estimated that more than 450 million women worldwide have menopause or
Starting point is 00:50:53 perimenopause symptoms. And based on the prevalence, this report says, the estimated market potential for medication is up to $230 billion globally. Hmm. The paper notes, investments addressing the women's health gap could add years to life and life to years and potentially boost the global economy by one trillion annually. So, hey, we should figure that out, America, because that's a lot of money to be made from menopause. Your uterus matters because your wallet does. Yikes. The lion's share of that women's health bucket went to pregnancy. Pregnancy's important. And then breast and ovarian cancer, okay? When we talk about autoimmune disease that 80% of women have, when we talk about intemitriosis, polysychevavivirin, like, diseases.
Starting point is 00:51:44 diseases that specifically affect and menopause, it was like dust, like pixie dust. So how does that translate? So if you go to the NIH website to look at research articles, so that's PubMed in the U.S. Or worldwide, we can do it worldwide. And I type in the word pregnancy, okay? Right now it's around 1.2 million articles. Now those articles represent brainpower, academics, research funding, you know, think of everything it takes to, like, create a research article and all the money and, preparation that goes into that. Okay. Now I'm going to type in the word menopause. We're about 99,000. Maybe close to a million now. That is 12 to 1. Okay. Now I'm going to type in the word perimenopause. And we are at 9,000. Dude. And paramenopause can last like 10 years, right?
Starting point is 00:52:37 Yeah. So just to give you an idea of this much funding, so 85% is taken away, Now we're going to, most of it's going to pregnancy. And that, you know, so here's the dust and the crumbles and the cobwebs that women's health after reproduction ends, which affects more women than it will bear children. Yeah. So that's kind of like my inspiration. Are you constantly having to refresh and see what papers are coming out and get abstracts? Yeah.
Starting point is 00:53:05 So the coolest thing about PubMed is that they'll let you put alerts in. So I have an alert for the word menopause and I have an alert for the word perimenopause. And every morning I get my coffee, I get back in my bed, I flip up on my laptop, and I review every single article. And there's not that many, Shadley, that comes out. So every day I see what has been published with the word menopause or perimenopause in it. That's so baller. And it's awesome. And I'm like, okay, and I read every abstract.
Starting point is 00:53:34 There's still a lot on cancer and menopause. So that's fine. You know, but like really clinically relevant stuff, we have a long way to go. Women are of centuries of research here. Yeah. Oh, a thousand percent. So who is doing that research? We're going to link to so many studies on our website, which is linked in the show notes,
Starting point is 00:53:52 or you can just go to alleyword.com slash ologies slash menopause. Well, do animals deal with this shit? I reached out to biological anthropologist, Dr. Lara Dirkovich, who you may remember from our episode on the sex lives of apes other than ourselves. And she studies menopause and orangutans. So at least someone's health is funded for that. Hello, Miss Allie. Thank you again for inviting me to comment on this stuff.
Starting point is 00:54:18 I'm very excited to be back on the show. And my research focus is on the life cycle of female orangutans, and specifically how their reproductive hormones and their menstrual cycles, which are pretty much the same as ours, change across their lifespan. And if or how those hormones impact the female's motivation to mate or the male's interest in mating with them. Hello ladies.
Starting point is 00:54:40 But the other thing I want to know a lot about is whether perimenopause and menopause are a standard part of the female life cycle. And if so, how long they tend to live afterward. Okay, awesome. Menopause is definitely rare in the animal kingdom. From an evolutionary perspective, the more offspring you have, the more copies of your genes you pass on to the next generation, and the more you are winning, so to speak, at the game of evolution. So it's super puzzling to see a life cycle evolve where individuals stop reproducing long before the end of their lifespan. There is evidence that some female orangutans, gorillas, and chimpanzees reach menopause and also some species of toothed whales like orcas and narwhalps.
Starting point is 00:55:27 Well, I asked her, how long are humans supposed to live? Are we even supposed to go through menopause or should we be dead by then? Humans have actually had a long lifespan for longer than most people appreciate. I think a lot of people think that the only reason we have a long post-reproductive lifespan today is because of modern medicine, that otherwise we'd typically be dead by 50. But actually in the past, a lower life expectancy was skewed by high rates of death at young ages. So if they survived childhood, it wouldn't have been unusual in ancient times for a person to live to something like 70, which for a woman means two solid decades of life postmenopause.
Starting point is 00:56:08 I mean organic foods, lots of exercise, healthy social environment, living in villages, weight-bearing activity from carrying water and other people's babies and rocks. You're hanging out in your campfires, but you're skipping the vape and bottomless mimosas of our current epic. That all kind of checks out. But why shut things down before the party's over? What is the advantage of menopause? This one is a million-dollar question within evolutionary biology, and it is one that we still
Starting point is 00:56:38 don't have a definitive answer for. In mammals, females are born with all the eggs they'll ever have already in their ovaries, and the physiological changes of perimenopause and menopause are the result of that number of eggs declining with age. This is called follicular depletion. The focus in evolutionary biology has shifted, and the question being asked isn't so much, why do we have menopause, but rather, why did natural selection favor an extension of the human lifespan beyond the age where we, or women at least, stop being capable of reproducing?
Starting point is 00:57:13 The most common explanation is something called the grandmother hypothesis, which was popularized by a woman named Kristen Hawks. And the idea here is that grandmothers can be particularly valuable in helping increase the reproductive success of their own offspring by helping to both provision and care for their grandchildren. By boosting their grandchildren's survival chances and possibly even helping their daughters have another baby more quickly, grandmothers are able to boost their genetic legacy indirectly through what's called inclusive fitness in evolutionary biology.
Starting point is 00:57:51 Thanks for Emma. I know there was a well-studied female orca named Granny that was fit into this mold. For more on that, yes, we need an orca episode. and I'm working on it. I know feelings are mixed on calling them killer whales, but I do feel like killer whales would be great for spooked over. So put a pin in that. But meanwhile, you can see the 2017 current biology paper titled Reproductive Conflict and the Evolution of Menopause in Killer Whales, which explains that the reproductive conflict hypothesis predicts that older females in a pod,
Starting point is 00:58:25 ceasing fertility is a benefit to the younger females, since males don't disperse from the pod so that avoids more interrelated breeding. But the 2019 piece in Science.org titled Granny Killer Whales Pass Along Wisdom and Extra Fish to Their Grandchildren. Touched on some new research showing the first non-human grandmother hypothesis in whales, noting that as wise grannies, they can help provide fish and knowledge of where to find them to the younger whales, and that greatly increases the survival rates of that young generation. Another effect, this has not been studied, but it's my hypothesis, is fashion because in 2024, young whales off the northwestern coast of North America, they were cruising around balancing dead fish on their head. No one really knows why,
Starting point is 00:59:16 except that in 1987, this was also a fad. It disappeared for decades, and then boom, whales started balancing fish maybe to amuse each other. So I think perhaps, a young whale was like leafing through a photo album, was like grandma looked hot, put a dead salmon on like a pair of grandma's acid washed jeans, just like throwback looks good. Nature, it's a mystery. But orcas can go through the dodging event around their mid-40s, even though they can live into their 80s and 90s, some even past 100. What about the less wet mammals? I have a colleague who was a veterinarian at a zoo in Jersey, and he's, published a paper last year where they used hormone data and ultrasound data and histology to
Starting point is 01:00:03 document menopause in a 49-year-old female orangutan. But we also know that female apes can continue to reproduce at ages that would be considered pretty late in humans. There was a female orangutan at the St. Louis Zoo who gave birth at 45. There was also a chimp named Susie at a zoo in Kansas who gave birth when she was 56. And as for Susie, she was taken off birth control, because that's right, apes in captivity, they're given regular old human birth control in a cup of juice every morning. We learned that in our primatology episode. But yeah, they took Susie off birth control for some other health concerns and, quote, zoo officials didn't think she would get pregnant at her age. But surprise, suckers, Susie was still freaky and she had a kid of 56 and then she lived until the age of 71.
Starting point is 01:00:49 And she just passed away in the fall of 2025, so RIPA legend. But we need more data to say whether the slope of the line is the same for hormone decline in humans and in other apes. As far as I know, there's no evidence that they experience things like hot flashes or mood swings, but obviously we cannot ask them. I wish we could. What about in convos with your human friends? Has research helped you or your friends and relatives in terms of their perspectives on the experience. And here, I have to say, sadly, no, I'm not there yet myself, but I think this is one of those things where understanding it better does not make it any easier to go through.
Starting point is 01:01:33 You know what else makes it easier to go through, though, is part two. Next week, we're going to move on from these basics and symptoms and tell you what you can do about all this. There's hormone options. We talk flim flam busting specific things to ask your doctor. Alternatives. latest research, why you want to make sure your hips stay intact, vagina creams, libido, so much more. Meanwhile, Dr. Mary Claire Haver has the podcast unposed and wrote the books, the new menopause book and the new perimenopause book. Dr. Monica Christmas is on Instagram at Dr. Monica Christmas. We'll also link her research gate as well as Dr. Lara Durgavich is. And of course, so, so many links will be up at alleyway.com slash ologies slash menopause. And again, we're back next week with all the stuff you need.
Starting point is 01:02:19 to know what you can do for yourself and or the people in your life who are going through this. It's very important. Now, we are at Ologies on Blue Sky and Instagram. I'm at Allie Ward on both. Allie has just one L. We also have kid-friendly episodes in their own feed that show is called Smologies. It's wherever you get podcasts, S-M-O-L-G-I-E-S. If your kids ever watch the show Brainchild on Netflix, that's me. I was their science friend on that, so there's a fun new podcast for them if they need one. Thanks again to patrons of ologies. Next week, it's all your questions wall to wall. And thank you, Aaron Talbert, who admin Zeology's podcast Facebook group. Aveline Malik makes our professional transcripts. Kelly R. Dwyer does the website. Noel Dillworth
Starting point is 01:02:58 tracks our weeks as our scheduling producer slamming down on my gas pedal to get the episode out on time is managing director, Susan Hale, who also did an amount of research on this episode that is staggering. Just give her a PhD for this. Susan, I may not have ovaries or uterus anymore, but I could not survive without you. And editing so wonderfully that I do not have to quit my job to marry my endocrinologist are Jake Chafy and lead editor Mercedes-Maitland of Maitland Audio, Nick Thorburn whimpered the theme music. And if you stick around until the very end, you know, I may tell you a secret. This week, it's something I think I mentioned in the All Secrets episode recently, but it's that I bought one of those little sticks with a grabber on the end,
Starting point is 01:03:40 like a claw grabber on the end to pick up trash on my street. And it all started with these pea bottles, They kept appearing in the bushes because multi-billion dollar corporations don't let their delivery drivers take breaks. So into the bottle it goes, into our bushes. I can't blame them. But I take this little trash picker on walks with Grimmy and Jarrett down the street and I just pick up trash. Honestly, here's the problem. Here's my thing. If I just took myself on walks around the neighborhood with this trash grabber, I would get so many steps.
Starting point is 01:04:10 It just keeps your brain kind of searching for litter in a way that really feels like, Pokemon Go, but with like hamburger wrappers and cigarette butts. But I know if I start doing that, which again, I like really want to, but I'll become that lady in the big hat with a garbage grabber. And I don't know if I'm ready to be that iconic and take on that kind of neighborhood lore right now. So if anyone else does that in your own neighborhood and just becomes it, just let me know how it goes. I'm tempted. Okay. Next week. week will actually materially change your life. So much information. Okay, talk to you then. Bye-bye. Well, I'll tell you, menopause was wonderful for me.

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