Passion Struck with John R. Miles - Dr. Scott Sherr on How to Improve Brain Function with Methylene Blue and Nootropics EP 321

Episode Date: July 20, 2023

Learn how to improve brain function with a powerful combination of nootropics and methylene blue. Join host John R. Miles and special guest Dr. Scott Sherr as they delve into the world of cognitive enhancement and health optimization medicine. Discover the science behind the groundbreaking nootropics Blue Carnitine, Just Blue, and Trocalm, designed to optimize brain health and unlock your mental clarity. Tune in and explore the path to a sharper mind and boundless potential. Get 10% off your Troscriptions order with code Passionstruck. Want to learn the 12 philosophies that the most successful people use to create a limitless life? Pre-order John R. Miles’s new book, Passion Struck, releasing on February 6, 2024. Full show notes and resources can be found here: https://passionstruck.com/dr-scott-sherr-how-to-improve-brain-function/  How to Improve Brain Function with Nootropics and Methylene Blue In this episode of Passion Struck, join host John R. Miles and special guest Dr. Scott Sherr as they dive into the fascinating world of nootropics and the mind's limitless potential. They explore the concept of the movie "Limitless" and discuss whether methylene blue, a compound with unique properties, could be the magic ingredient that unlocks extraordinary cognitive abilities. Brought to you by Hello Fresh. Use code passion 50 to get 50% off plus free shipping!  Brought to you by Lifeforce: Join me and thousands of others who have transformed their lives through Lifeforce's proactive and personalized approach to healthcare. Visit MyLifeforce.com today to start your membership and receive an exclusive $200 off. Brought to you by OneSkin. Get 15% off OneSkin with our code [PassionStruck] at   #oneskinpod. --► For information about advertisers and promo codes, go to: https://passionstruck.com/deals/  Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter or Instagram handle so we can thank you personally! --► Prefer to watch this interview: https://youtu.be/H7E_9yvSINI  --► Subscribe to Our YouTube Channel Here: https://youtu.be/QYehiUuX7zs  Want to find your purpose in life? I provide my six simple steps to achieving it - passionstruck.com/5-simple-steps-to-find-your-passion-in-life/ Catch my interview with Marshall Goldsmith on How You Create an Earned Life: https://passionstruck.com/marshall-goldsmith-create-your-earned-life/  Watch the solo episode I did on the topic of Chronic Loneliness: https://youtu.be/aFDRk0kcM40  Want to hear my best interviews from 2023? Check out my interview with Seth Godin on the Song of Significance and my interview with Gretchen Rubin on Life in Five Senses. ===== FOLLOW ON THE SOCIALS ===== * Instagram: https://www.instagram.com/passion_struck_podcast * Facebook: https://www.facebook.com/johnrmiles.c0m  Learn more about John: https://johnrmiles.com/  Passion Struck is now on the AMFM247 broadcasting network every Monday and Friday from 5–6 PM. Step 1: Go to TuneIn, Apple Music (or any other app, mobile or computer) Step 2: Search for “AMFM247” Network

Coming up next on Passion Struck. And the reason why we named it blue tropics is because the main new tropic that we use in our compounds is something called methylene blue. And methylene blue is a compound that's been around a long time that has both capacities. It has the combination to both increase the health of the brain.

And at the same time, increase the brain's potential to perform a task better because of the various mechanisms that are at play here. So it's increasing energy production, but it's also supporting the production of energy and balancing out energy production by increasing something called antioxidant reserve. Welcome to PassionStruct. Hi, I'm your host, John Armiles. And on the show, we decipher the secrets, tips and guidance of the world's most inspiring people and turn their wisdom into practical advice for you and those around you. Our mission is to help you

unlock the power of intentionality so that you can become the best version of yourself. If you're new to the show, I offer advice and answer listener questions on Fridays. We have long form interviews, the rest of the week with gas ranging from astronauts to authors, CEOs, creators, innovators, scientists, military leaders, visionaries, and athletes. Now, let's go out there and become PassionStruck. Hello everyone and welcome back to episode 321

of PassionStruck, consistently ranked by Apple as one of the top 10 most popular health podcasts, as well as being the number one alternative health podcast. And thank you to all of you who come back weekly to listen and learn how to live better, be better, and impact the world. PassionStruck is now on syndicated radio, on the AMFM247 National Broadcast. Catch us Monday and Friday from 5-6pm Eastern Time, on Apple Music, Tune in, or wherever you listen. Links are in the show notes.

If you're new to the show, thank you so much for being here. Or you simply want to introduce this to a friend or a family member. We now have episode starter packs, which are collections of our fans' favorite episodes that we organize in the convenience of topics that give any new listener a great way to get acclimated to everything we do here on the show. Either go to spotify or passionstruck.com slash starter packs to get started. In case you missed it, earlier in the week, I interviewed renowned speech coach Samarro Bay who suggests that giving yourself permission to speak is the key to affecting change.

Samarro's groundbreaking approach to public speaking offers a new definition of what it means to sound powerful, which is essentially sounding like yourself. Please check that episode out. I also wanted to say thank you for your ratings and reviews. If you love today's episode, we would appreciate you giving it a 5 star review and sharing it with your friends and family. I know we and our guests love to see comments from our listeners. Now let's talk about our episode. Today we have a very special guest returning to the show. Dr. Scott Schur, an internal medicine physician, certified in hyperbaric oxygen therapy known as

HBOT and health optimization medicine. In my previous interview with Dr. Scher, we delved deep into the fascinating world of HBOT. Today we're thrilled to have him back on to discuss the latest advancements in this field since our last conversation over a year ago. But that's not all. We'll also be diving into the realm of cognitive enhancement, exploring the remarkable potential of neutropics and their impact on brain function. For those unfamiliar with Dr. Scher's clients, they include high-level athletes, silicon valley entrepreneurs, biohackers, and individuals seeking to unlock their full cognitive potential. During today's captivating discussion, we'll be addressing intriguing topics such as

health optimization medicine, the power of neutropics, and the innovative, pro-key delivery method. We'll also explore the science behind methylene blue and its potential therapeutic benefits. Additionally, we'll dive into tropic descriptions, accompanied by Dr. Shira not only does descriptions offer groundbreaking, neutropic products, but they also prioritize giving back. Dr. Shira will enlighten us on the philanthropic ventures associated with tropic descriptions, including the home and hope initiatives. So whether you're a seasoned biohacker or simply curious

about enhancing your cognitive performance, this episode is packed with valuable insights and actionable advice. Get ready to expand your understanding of cognitive enhancement and discover new possibilities on your own passion-driven journey. Now to further ado, let's dive into this enlightening conversation with the brilliant doctor Scott Schur. Thank you for choosing PassionStrike and choosing me to be your host and guide on your journey to creating an intentional life. Now, let that journey begin. don't do repeat gas very often, but you're in some pretty good company because the other two I've had back on the show are Seth Goden and Gretchen Ruben. So glad we could bring

you into that fold as well. I have a lot to live up to. Well, the last time you joined the show, we extensively discussed your expertise in hyperbaric oxygen therapy. And I wanted to ask you to start this episode out. Are there any new development in a choice since we last spoke over a year ago? That's a great question. I would say that there hasn't been any breakthroughs, any major changes since we had our last discussion. I would say that there are more people using hyperbaric therapy now than ever before. I get a lot of different kinds of things that people ask me, are they bariatric chambers,

are they hyperbolic chambers, are they cryo chambers? And understandably, it's a very strange word, hyperbaric oxygen therapy. But I get very little of that these days. I used to get a lot of that. So I think the amount of information out there, there have been more clinics that have opened, especially a clinic down in Florida called the Aviv Clinic, which is run by the Israelis. It's a for-profit company that's doing very large amounts of hyperbaric therapy and doing a full spectrum, doing a diagnostics before, during and after.

I think for me, the trends continue though, John, in the sense that more people are getting these chambers in their homes, and more people are interested in helping optimize and understanding a little bit more about why oxygen is so important, but also having a healthy respect for oxygen, both high levels and low levels, and how this all can be helpful. Yeah, I actually was reading a few weeks ago, some recent studies that are showing that HBOT can improve neurocognitive functions by inducing neuroplasticity and improving brain function. Are you familiar with any of that work?

Yeah, so this has been going on for maybe about six or seven years now. The idea really is that if you can turn on the brain by giving it more oxygen, increasing the amount of blood vessels that are growing in the brain that may have been damaged from a stroke or a traumatic brain injury, or even just from degeneration from time, after about the age of about 55 years or older

or anybody else, our brain start deteriorating. And you can actually see this on MRI and you can see these findings. And we know that there be can likely reverse a lot of this by increasing the amount of blood vessels in the brain. And also enhancing stem cell release. And stem cells are these baby cells that can form any different type of cell

in your body and your brain. And so you can regenerate tissue. And now we have imaging from an MRI scan, actually. It's a very fancy one called a functional MRI, where you can take a look and see brains turn back on. You can see areas of the brain that weren't functioning very well and now functioning very well after hyperbaric therapy. And neuroplasticity is the result of a better functioning brain.

Because if neurons are getting more fuel, if the supporting cells are getting more fuel, they're going to work better. And so this is not done in a silo. It's obviously better done in a more comprehensive strategy where you're looking at optimizing diet and lifestyle and physical therapy and occupational therapy and other types of technologies. But certainly neuroplasticity is enhanced in a hyperburet chamber. And so I've used it in the sense of with other neuroplastic types of technologies like neurofeedback or some of these other kinds of therapies that

are working on reprogramming the brain. The brain when you do these kinds of therapies is really hungry for oxygen because oxygen is what helps the whole system shift. And so you put them in a hyperbart chamber after they've done their neurofeedback or after they've done their intensive occupational therapy on the hand that's only working kind of part of the way or something like that. And you can see dramatic changes that way, for sure.

Well, we're gonna be spending a lot of time today talking about how to improve cognition and overall performance in our days. But I wanted to set this discussion up because on the podcast, we have had many guests who practice functional medicine or alternative medicine. And you were involved with something called health optimization medicine.

And I wanted to ask, how is that different? Yeah, so I grew up the son of a carer-practor. And I always had the feeling, ever since I was a kid and watching him in the office, is that all you needed really to do for most people, is just give the body what it needs, and it will heal itself. That was the slogan something similar to that.

And the problem oftentimes, even with functional medicine, although I have a lot of functional medicine colleagues, and I respect the field greatly. And especially on the illness medicine side, conventional medicine, is that we're often either looking to treat an illness or look for the root cause, but forget that there are basic operations

that are happening at our cellular level that all of us need to be functioning well to operate on any of the other levels. So before you look at the root cause of illness, what you really need to be looking at is the root causes of health. And so this was a framework that was developed by now a colleague of mine, an amender,

his name's Dr. Ted Chico. So he's an anti-aging physician. He's a very prominent physician in the Philippines, but also has been in the US for many years as a tri-continental practice. And he trained as an anti-aging doc and created this framework called Health Optimization Medicine and Practice, which is a nonprofit organization now that's

training doctors and practitioners on how to optimize health rather than treat disease. It's really interesting to say, because I'm an internal medicine doc. I train very conventionally grew up the son of a car practice, as mentioned. But there is standards of care for disease. We know that the standards of care are for blood pressure management for diabetes, but there's really no standards of care for health. What is health? How do you define health?

And how do you optimize it? So I often think of health optimization medicine as the foundation of it all. No matter what else is happening, you need to have optimized levels of vitamins, minerals, and nutrients for your mitochondria to work well. If you're gut to work well, it needs to have optimized levels of microbiota and commensal bacteria. And so you have all of that's required for anything else to work well. So the basic cell, your mitochondria, your nucleus, your endoplasmic reticulum, your aspects of your cell that you need to work well, there's really that nobody that takes care of that. And that's what health optimization medicine is all about. Well, thank you for that.

What a interesting approach. And how many physicians or nurse practitioners have you put through the program? I think it's called home or hope. So we have health optimization medicine, which is for medical practitioners. And we have health optimization practice, which is for non-licensed healthcare practitioners, basically. So people that don't have licenses, but like they're still practicing in various ways, this could be health coaches and

all the like in that capacity. We know this to be the case that doctors tend to be limiting in the sense that there's not that many of us out there, especially that there's not that many of us that are interested in optimizing health and looking at alternative ways of doing this. And so we have the two ways of training, although the training is very similar, you get a different name afterwards, either your health optimization medicine practitioner, or your health optimization practice practitioner, basically.

And so the idea with the training is it's a seven module certification, and it goes through multiple different topics that nobody learns in medical school. And the first one is probably the most important. It's called metabolomics. And there are some articles that were written on metabolomics in the earlier part of this century, this millennia, and calling metabolomics the stethoscope of the 21st century. And the idea here is that the metabolomics is telling you what's actually happening in your cells right now. So it's giving you a sense of your mitochondrial function,

it's giving a sense of your environmental exposures, it's giving you a sense of your diet, your lifestyle. So you can see all this happening in real time. And it's basically a three to six month window on what's happening. And so you can do this and you can look at what's happening right now. And so as a comparison, your genome, obviously, everybody knows what their genome is. Your DNA tells you what may happen. But it's in stone. It's not going to change. And you have your epigenetics, right, which your epigenetics is on a layer on top of that. If you want to go in order, we have your DNA, your genome, and you have your epigenetics, right, which your epigenetics is on a layer on top of that. If you want to go in order, we have your DNA, your genome, and you have your transcriptome,

is how you transcribe your DNA. Then you have your proteome, which is how the DNA is transcribed into proteins. And then you have your epigenome, and then you have metabulum, right? So you have all these different layers. And so it's funny, actually, there's a couple of articles that came out of Stanford a couple of years ago. They called it your narcissome. Eventually what's going to happen is that we're going to have all these things sequenced for ourselves. It's everything about us on all these various levels because there's knowledge that you can get from every single level. But from our perspective, the most knowledge you can get right now is on the metabolomic level. The sciences have been around for the last 20 years, but they really haven't been used in clinical practice up until very recently. And even then, it's only mostly being used for disease, which is fine, but you can actually use metabolomics to actually measure things that

are happening in your mitochondrial right now to see how well you're making energy and how well you're detoxifying from energy and metabolism and how well your body is detoxifying from toxins, are there toxins in your system? Are they mucking up the system? So you can measure all these things and their bioproducts are metabolites basically. And so that's what we do. And that's the foundation of health optimization medicine is that you want to focus on that metabolismic piece. And but the other corollary to this is that you want to make sure

That you're not normal for your age if you're 65 years old or 55 years old Do you want to be normal 55 or do I want to be normal for 53 or 43 when I'm gonna be 43 in a couple weeks? No, I want to be optimized for the levels of somebody between 21 and 30 years of age And so the idea is that we shift all your metabolites and your hormone levels as well Into the levels between 21 and 30 years of age. That's when we're optimized. Everybody remembers being 21 to 30. You're pretty much invincible for the most part.

You can sleep very little. You can eat whatever you want to some degree, although this is not exactly true anymore, John, as people are getting more toxic earlier and earlier. But in essence, this is when we were most primed to procreate and to fight. And that's how our bodies were made to survive up until about 35 years of age. And then we were going to dive infection or war or whatever. And that was the natural history of the human form for many years. But so the idea with health optimization medicine is to shift all those metabolite levels hormone networks to the ages of 21 and 30 years of age.

And so that's the really the key difference oftentimes for what we do compared to what a functional medicine doctor might do, which is looking for the root cause of your illness, which is totally appropriate, but may not be addressed as comprehensively as looking at that foundation, at least alongside what you're doing. The final thing I'll say there is that this was extremely important to me in my hyperburet

practice because I realized that people weren't doing well sometimes. And I realized that they weren't doing well because they couldn't make energy well or they couldn't detox from the energy that they made because when you make energy, you make waste product of energy metabolism. So this became a huge part. And is a huge part of my hyperburet practice now is this is my foundation health optimization medicine practice. Man, well, it's fascinating. I for a while was sponsored by Inside Tracker and it was interesting to me when I was on their program how I was able to move my own biological age back over a decade

biological age back over a decade by doing simple behavioral change interventions, supplements, and really examining what my blood level was and how my gut, my microbiome was functioning and then doing things to better it. So this stuff definitely works as I saw through my own experience doing it. And I think the key is that oftentimes as humans, we want immediate gratification. We want to see things change tomorrow. The line that we typically use is that it took you 40 years to get to where you are. It's going to take time to optimize your health. And that's really the key with health optimization medicine and practice is that it's a long term. Idea, it's a long-term idea.

It's a long-term plan. It's not something that's supposed to happen and help you immediately, although it can, absolutely, especially when you're using things like neutropics and other things that can help you along the way to help you right now with mitochondrial function. But the idea is that if you want a sustainable health foundation, this is going to take time to optimize levels of vitamins, minerals, and nutrients. This is from your experience. I'm sure too, John, when you were going through it, it really is something that doesn't happen overnight. And certainly you can make changes overnight that can have significant benefit. But you know, oftentimes with our patients, it's like, well,

I didn't get sick this year. Or when I did sick, get sick, I only was sick for two days as opposed to 14 days. When I went traveling, I didn't have jet lag that was so terrible. I didn't only have jet lag for a day versus a week or et cetera. You can fill in the blanks. Oftentimes, unfortunately, our health is in the rearview mirror. We're looking at it from the back, right? Instead of being more proactive about it. The idea with health optimization medicine is, can we train practitioners?

Oh, and I forgot I didn't answer your original question. Did I? Can we train practitioners to use this in their practices so that they can use this in combination with the other things that they're doing? So for me, it's hyperburetic therapy. For somebody like a chiropractor, it could be along with chiropractic manipulation and other kinds of things. For a cancer doctor, it can be used as something as a foundation in that capacity,

too, because it's not mutually exclusive to anything you would do. You want to have optimized levels of antioxidants if you have cancer or if you don't have cancer or if you're a high-level athlete or et cetera. But to answer your original question, which I completely blew, sorry about that, is we're a new organization. There's not that many of us and what we're hoping to do, we're having a first our first cohort of a practitioner that are finishing next month in July of 2023. And what we're hoping to do, we're having a first, our first cohort of a practitioner that are finishing next month in July of 2023. And we're looking at repeating this in September. So definitely interested in talking to practitioners that are thinking about adding something to their practice. They're interested in a health focus. They want to keep what we say is setting disease aside for a little while and just focusing on health.

And that was very provocative for me as a son of a carer-practor. Like, is that really new? That's what I wanted to do with my patients. His focus on their health and then everything else would get easier. We'll be right back to PassionStruct. Today's episode is sponsored in part by Troscriptions, a game changer and cognitive optimization. Are you ready to take your energy focus and cognitive performance to the next level? Look no further than just blue from troc descriptions. Just blue is a powerful supplement designed to boost your energy clear brain fog and crazy resilience and enhance your memory. With 16 milligrams of pure methylene blue, one of the most potent mitochondria optimizers on the planet,

just blue is here to supercharge your cognitive abilities. And personally, I've been using just blue for a while now, and let me tell you, it is a game changer. When I need to tackle cognitive tasks with laser focus, just blue is my go-to hack. I can really feel the difference it makes part of my podcast interviews. So if you're ready to unlock your full cognitive potential and experience heightened mental clarity, I highly recommend giving just blue a try. Visit trowscriptions.com and use code passion struct to get your hands on this incredible supplement today and 10% off. That is TRO SC RIP TIONS.com and use code passion struct to get 10% off.

Now back to the passion struct podcast. Thank you for answering that and I'm sure if there are any medical practitioners who are listening to this, that's some great information for them. One of the things in addition to your practice that you're involved in, is you're the chief operating officer, if I have that correct, of transcriptions.

And I wanted to ask, how did you get involved with the creation of new tropics and their overall use? Yeah, so I was alluding to it just before. So we have this nonprofit that we've spoken about here, and I hope that was helpful for people that are interested. You can go to homehope.org and find out more information. And I've done podcasts on this. Dr. Ted has done podcasts on it as well.

He's the founder and pioneer. And so there's a lot of great information there. And there's a free module that you can sign up for to learn more. But the key here, John, is that as I was describing, optimizing your health takes time. It's not something that happens overnight. So you need things that can help you right now

along the way so that you can feel better along the process of optimizing your health for the longterm. And one of the major things that we saw as a company, as the nonprofit, was that we found tons of people with brain fog might accountual dysfunction, just having a hard time with exercise and do fatigue. And we knew that we needed something to help these patients, our clients brains function better.

And so Neutrox is something that I've known about for a long time, Dr. Ted as well. And so we decided that we would create a for-profit company called Troscriptions, the umbrella name of the company is smarter, not harder, which is, I think, a phrase that's being used a lot these days. But we say we're not a condom company as well, of course. But at the same time, Troscriptions was created as a way to deliver instant help to our patients and clients while they're doing the harder work of optimizing

their health over the long term is what it comes down to. And so the first area that we tackled was brain function and neutropics. So that's how we got involved. And if someone's not familiar with neutropics, how do they differ from other cognitive enhancement methods such as caffeine or Supplements or prescription medicines? So the actually the term is very confusing. So I appreciate you mentioning it because all Neutropics really means is brain enhancing compound. That's it. And so it can be confusing because there can be lots of different varieties. So is caffeine a newtropic? Yes. Is nicotine a newtropic? Yes. Is eltyrosine an amino acid a newtropic? The answer is that it can be as well.

So this is the deal. When we first started the company, we decided that we had to define newtropics better so that you had more of a delineation of what type of newtropic you were taking. Okay. And so for us, there are basically three types of neutropics, and I think this will be helpful for people. The first type is called the health optimizing neutropic. Obviously, similar to the name of our non-profit, but health optimizing neutropics. That's the first category. The second category is performance optimizing neutropics. And the third category we call blue tropics. Okay, so you have health optimizing neutropics, performance optimizing

neutropics and blue tropics. Let's start off with health optimizing neutropics. These are neutropics that are healthy for the brain and enhanced brain function. That may seem like it should be the case, but it's not always the case. So these are things that enhance the brain function

but are also healthy for the brain. Okay, so this could be something that is supporting brain function like L-tyrosine, for example, which is an amino acid that helps support neurotransmitter synthesis. So it helps with dopamine and neuro-inuripanephrine in the brain. So you have more neuro-inuripanephrine and dopamine if you have L-tyrosine, for example. CBD is something similar because it helps with increasing

and neurotransmitter called anandamide, which helps to support the brain and helps with decreasing inflammation. Okay, so you have these health optimizing neutropics. These are things that enhance the brain function, but are also healthy for the brain. They're protected for the brain in various ways. Then you have performance optimizing neutropics.

And these are the ones that most of us know about already. This is your caffeine. This is your aderol. This is your racetam family of neutropics. This is your caffeine. This is your aderol. This is your racetam family of Neutropics. This is nicotine. Okay. These are all things that help the brain to perform better at a task, but may not be healthy for the brain. Okay. And so they may clock the brain over time. They may increase neurotransmitters. They may increase energy production. They may do something that helps your brain function for fitness for a specific task, but they may not be healthy

for the brain. The third category is blue tropics. So it's the combination of the color blue and the word tropic, or the part of the word tropic, they're blue tropic. And the reason why we named it blue tropics is because the main neutropic that we use in our compounds is something called methylene blue. And methylene blue is a compound that's been around a long time that has both capacities. It has the combination to both increase the health of the brain. And at

the same time, increase the brain's potential to perform a task better because of the various mechanisms that are at play here. So it's increasing energy production, but it's also supporting the production of energy and balancing out energy production by increasing something called antioxidant reserve. So you have these three categories. You have health optimization, neutral picks, performance optimization, neutral picks, and blue tropics.

But the foundation of all of this is that your cells are working well, right? That you're optimizing cellular function so that you can actually perform these tasks better and not overclock your brain. So the foundation to brain optimization is health optimization is what it comes down to. So that's why our nonprofit and this company, the transcriptions company are so paired and so aligned together. Okay. I did want to ask you some more questions about methillion blues.

So I'm glad you introduced it. Since you were just talking about how our body functions, how does methillion blue work at a molecular level? So this is a compound that's been around a long time. It was the first drug registered with the FDA back in the 1890s. And it's interesting. It came from the FDA back in the 1890s. And it's interesting. It came from the textile world in the mid 1800s. It was the dye that was used to dye blue jeans glue, interestingly enough. And so it is a synthetic product, but its safety profile is fantastic.

It's been around a long time. And the mechanisms have been delineated over many years, as you can imagine. For our purposes on the Neutropic side of things, what it does is help with mitochondrial function. It does this in a couple of different ways. But the main way is that it increases the amount of energy that you make, increases the amount of ATP that you make. And at the same time, it also increases antioxidant reserve, meaning that when we make energy, when

we make ATP, just like you're putting gas in your car, there's going to be exhaust, there's going to be waste products. Okay. So the waste products of energy metabolism, the mitochondria are not all bad. You need these things, actually, but if you have too much of them, it could be bad. And so you have, when you make energy, you make ATP, which is our energy currency of ourselves, you make water. That's fine. We make carbon dioxide. We need carbon dioxide. It's a fantastic signaling molecule. At the same time, we breathe it out when we take our breath, right? And then we have what are called free radicals or oxidative stress, or there's multiple different words for this. But what those are are signaling molecules. These are what are called singlet oxygen. So

anyway, these are free radicals and these are really important for signaling. But if there's too many of them, the mitochondria can get under stress and it can cause deterioration and function, etc. and cause symptoms. It can cause brain fog and cause fatigue and cause inflammation, etc. And so you have antioxidants in the body that balance out this free radical formation from energy metabolism, but not always. If you don't have enough antioxidant reserve, you may not be able to do this and the people with chronic medical illness and chronic inflammation oftentimes are depleted in antioxidant. So it's very difficult for them to do this. So the beautiful thing about methylene

blue and very unique about it is that not only is it helping with energy production, but it's also helping you with this antioxidant reserve. And so as a result of that, you can use it in patients and in yourself, and people that have chronic inflammation that may be very sensitive to various things, or maybe very early on in the process of recovering from inflammatory kinds of symptoms,

whether it be post-infectious inflammation, or if it chronic inflammation from an autoimmune problem, etc. You can use a very low dose of methylene blue and see significant benefit because it has the capacity to do that. In addition, in people that have a lot of chronic complex medical illness or they're trying to recover from an infection, have inflammation. Oftentimes, it's the first two complexes on the mitochondria that don't work very well. And there's four total, okay? And the first two are the most important,

usually, to how we make energy. The first two complexes, the ones that take electrons from our food, we basically are eating food so that we can take electrons from our food in what's something called the crev cycle and bring them into the mitochondria to help you make energy, okay? Absolutely what food is all about, except it does other things obviously but the most important is to make energy. And oftentimes you'll find in people that have had chronic inflammation, post they have severe infection, autoimmunity issues, they often have problems with the first two complexes.

And the beautiful thing about methylene blue is actually bypasses those first two complexes and donates electrons directly to the fourth complex, which is called complex four, or cytokromoxidase, and so directly to complex four bypassing. And so even if you have mitochondrial dysfunction, you can still get the benefit of using methylene blue. And that's a beautiful thing, especially when you're doing with people that have lots of chronic issues

and chronic inflammation unfortunately. especially when you're dealing with people that have lots of chronic issues and chronic inflammation unfortunately. Scott, are there any precautions or side effects of using it? Yes, so as I was mentioning, it's been around a long time. The side effect profile has been pretty worked out. A lot of it depends on the dosing. So when you're talking about methylene blue, you're often talking about dosing at very low doses or higher doses, depending on the indication. So the way we created the products at transcriptions was a product that was 16 milligrams, which is pretty low dose. Most of the data out there from a safety profile perspective, being an issue is greater than 1 milligram per kilogram, which is about a 70 milligram dose for

the average American, so much higher than that. Okay. And so we used very low dose because it was a dosing that's being studied in Alzheimer's and Parkinson's in actually in depression and bipolar disease as well. The dosing that's been studied is around 16 milligrams. So that's the dosing that we decided that we wanted to stick with for our particular compound dosing in our formula in our delivery device called a trophy to ourH-E, which is these little small dissolvable lozenges that dissolve between your upper cheek and gum and dissolve over about 15 to 30 minutes. And they're scored, which means you can have either a quarter of it, a half of it, three quarters or a full depending on what you're needing your dosing. That was really important to us as a company

because we know that people are very sensitive in general and that everybody's got their own dose so you can titrate it that way. So when it comes to side effects, the major things you want to think about here is that number one, they're dose dependent. So the higher the dose, the higher risk of having an effect on your gut microbiota. So we know that after about 50 milligrams a day or so, there is a risk of affecting your gut biofilms, which are really important. Everybody has a film on their teeth. Even if you brush your teeth, they're always going to be a film. We have that same kind of film in our gut, and that has a lot of different types of bacteria, fungus, and virus. It's usually healthy, but it can be unhealthy too. So we're using higher doses of methane blue for things like Bartonella, which is an infection that's

commonly seen with the lime tick, for example. So you have to be careful at higher doses for, affected in the gut microbiome. And then at higher doses of methane and blue, at that 70 milligram or more, you have to be thinking about also, what methane and blue does is got this dose response curve. So at a higher doses,

instead of it being helpful and causing energy production, it can also be very stressful to the system and cause out more oxidative stress. So you have to be careful because higher doses can build up in the system over a long period of time, but also can cause gastric ulceration at higher doses like this too. And the other things you have to think about are interactions with other medications. The major medication you have to think about here is serotonergic drugs. So these are SSRIs or antidepressants and some of the newer antidepressants are called the SNRIs. Now, one of the mechanisms that I didn't mention yet is that methylene blue also is something called the monomine oxidase inhibitor. This means that it helps prevent the breakdown

of certain neurotransmitters in the brain, noreanephrine, serotonin, endopamin. So this is why methylene blue itself has been studied as a antidepressant and as something for bipolar disorder, which is in clinical trials right now. Of course, side note, they're all drugs derived from methylene blue because you can't patent something that's been around

for over 100 years that works extremely well as we all know Side note anyway, so the side effects piece was it's been around for a long time But because of the serotonergic part of this stuff there is a potential interaction with if you're taking an SSRI and taking methylene blue together you worry about there could be too much serotonin in the synapse, and as a result of that, causing something called serotonin syndrome. And very rare, and we've never seen it, and our dosing, it's extremely rare,

but we do say that if you're taking an SSRI, or an SNRI type of medication, that you wanna be talking to your practitioner, and if you're going to use the methylene blue, just make sure your practitioner is aware of this so they can monitor you. But in general, it's a very rare risk. You also don to use the methylene blue, just make sure your practitioners are aware of this so they can monitor you. But in general, it's a very rare risk. You also don't want to take methylene blue if you're pregnant or your breastfeeding because

it could be risky in those cases, but in a lot of other medications and supplements and things like that. But it's a extremely safe drug and it's something a compound that's been around for a long time. And in fact, it's still on the list of the World Health Organization's list of essential medications. I know people have a various ways of feeling about the WHO in general, or Bethlehem Blue, in that it's still used medically for carbon monoxide poisoning and for cyanide poisoning. So carbon monoxide poisoning, Bethlehem Blue helps hemoglobin, which is on red blood cells

carry oxygen more efficiently. definitely blue helps hemoglobin, which is on red blood cells, carry oxygen more efficiently. So it actually dumps off carbon monoxide molecules that get stuck there and won't let the oxygen carry. And that's what happens in carbon monoxide poisoning. So if you don't have a hyperbary chamber around, definitely blue is a fantastic additional way that you can help somebody reverse their carbon monoxide poisoning.

Now, I don't recommend getting poisoned with cyanide, but what cyanide does is actually destroys the first two complexes of your mitochondria. And so, if you give me a flamethrower, you're bypassing those complexes like we talked about before, and you're allowing energy production to continue as a result. So, don't try it at home, please, ladies and gentlemen. Don't go to Russia anytime soon and get poisoned. I don't think they're using cyanide, actually. They're using some crazy video isotypes of other things, but you get what I mean. So, but cyanide is not that common,

but it's still on the World Health Organization's list for essential medications for these reasons. And it's also being now used more commonly, again, as an anti-infective. Back in the 1890s, it was used from malaria. And up until the 1950s, at higher doses, the year and 1 milligram per kilogram, it was being used as an anti-infective because that was all that was available. And it was actually fantastically effective for urinary

track infections, for viral infections, for fungal infections, for protozole infections. But the main side effect was that the higher doses that you take, methylene blue concentrates in the urine after you take it. So if you take oral methylene blue concentrates in the urine after you take it. So if you take oral methylene blue or take it IV or it doesn't matter or in a troughkey, as I was talking about before, it's going to concentrate in your urine as it's going out. So you're going to urinate a blue color most likely

after you take it. So it can be blue, it could be green if you take in your B vitamins that morning, but there will be some blue urine. It's something people need to be aware of, but it's completely benign as a side effect. And that's actually some positive, in the sense that for people with chronic urinary tract infections, it's used in derivations of methylene blue are used as a preventative for especially postmenopausal women that have chronic urinary tract infections, use methylene blue or a

derivative of it to prevent recurrent infections, pretty fantastically as well. Thank you for that explanation. Scott, when you think of that movie Limitless with Bradley Cooper, is this methylene blue hypothetically that magic ingredient that made him limitless? So, Bethlehem Blue is a fantastic way to support energy production, to make sure that you don't have the side effects that Bradley Cooper had when he took too much of his NZT, as you guys probably remember from the end of the movie. But the actual focus, the stimulant, part of it, the actual drive, that's when you need something else.

And that's what we created something called blue canotine. And blue canotine is our Neutropic formula. This is our blue tropic stack, as we call it. So it's a blue tropic because it has methylene blue, but it also has nicotine, caffeine, and CBD. So it has CBD, which is health optimizing Neutropic, and it has nicotine and caffeine, in which are both performance optimization Neutropics.

Now, everybody knows caffeine. It's the most widely used and neutropic in the world by far, but nicotine's not too far behind. So nicotine's obviously gotten a bad rap because it is the main ingredient that we know about in cigarette smoke, in vaping products. It's the main ingredient, and it does have addictive capacity. Now cigarettes and vaping products have about 8 to 50 milligrams, 5-0 milligrams of nicotine per cigarette or per vaping product. And when you smoke and vape something, it immediately hits your bloodstream when you inhale it. Now, the dosing that we're using at transcriptions and our blue canteen is 1 milligram, 1 milligram total. It's non tobacco derived, it's pharmaceutical grade. And in our trocheys, as I was

describing before, they can take a quarter or a half or a full. Most people take a half of a troche at a time, and that's only one half milligram of nicotine at a time. And these trocheys are dissolved in your mouth between your upper cheek and gum up here. And when you do that, the ingredients dissolve into the buckle mucosa, which is your cheek. Over here, dissolve directly into the circulation of your brain.

So you start feeling the effects within about 15 to 30 minutes. And so, this is our limitless compound. This is our limitless formula because it makes you feel flow, verbal fluidity, your concentrations up, your verbal fluidity, your concentrations up, your memories, your focus is up, and you have it for about three to five hours. And there's no calm down, there's no crash, it's a slow rise over about 15 to 30 minutes. And the CBD and the methylene blue in there are protected.

This is the first formula that we developed actually, it was called blue canotine, who wanted something that you could have that you needed to be on and you just needed to be on right now, kind of thing. And not only was it just nicotine or caffeine, it was something that was supporting your brain at the same time. And so it has the methylene blue in it. So it's supportive and it dissolves in your upper cheek here. And with all of our formulas, by the way, so that we have a pure methylene blue troche called just blue.

And that's 16 milligrams. And we have the blue canteen that we're talking about here. All of these can be swallowed as well. The challenge with methylene blue is that it does make your mouth blue. And so that is mouth blue, urine blue, in and out, it's going to be blue. Okay. So for people that have more cognitive related issues, I do think that dissolving in the mouth can be really nice because it helps with that cognitive function quicker as opposed to swallowing it, which can take a little bit longer for you to feel the effects. So, but you can swallow our trokeys as well, usually best on an empty stomach, but the blue canteen is the one that's really the one that's going to give you the drive, the

focus, the concentration for most people. There is a small subset of people, and I was just on the phone with somebody just before our call today is a practitioner in England who loves our pure methylene blue product. It gives her focus. It gives her everything I just described for blue canotine without the nicotine and caffeine. So you do have some people that are very sensitive to the blue itself, the methylene blue itself, and don't need the nicotine and caffeine, but usually it's the blue canotine that's more like our stimulant equivalent, our aderol-like equivalent without the jitters and without the come down.

So we've had a lot of practitioners that work with patients that are able to titrate them off their stimulant medications using this particular formula, for example. Okay, and I understand you have a newer product as well called Pro-Comb. Yeah, so this is a very different type of product because it doesn't have methylene blue and it's more focused on the GABA system in our brain. Now GABA is a neurotransmitter as well. Not as well known as our fancy ones,

our neuro-epinephrine, our adrenaline, our serotonin, our dopamine, everybody loves dopamine these days. Everybody always loves dopamine. But GABA is like the black sheep of the family. The problem is that we're not thinking about Gabi enough. The context is always important here, John. The idea for us is as we're health optimizing people in our practices and my practice, we wanted something that could help with focus right now. Freedom from the lack of focus, that's blue canteen. And then we wanted something that could help with mitochondrial function right now. So freedom from the lack of energy right now, right? You could have energy

right now, you have antioxidant reserve right now, you can lift your brain fog, you can decrease inflammation, you can see the effects of methylene blue very quickly in most people. And so the next formula that we created was we wanted our patients to have some freedom from anxiety and stress as soon as possible because we know that that's a very significant hindrance to healing because when you're always stressed, you're always in what's called sympathetic mode. You're always in fight or flight mode, right? You're always looking for the tiger, even if you don't want to be. And we know this in your work, in my work, in PTSD, in traumatic brain injury and the veteran population, this is a big deal. So you really need to calm down the nervous system. And the crazy thing is when you calm down the nervous system

You're going to perform better. So this is a common example if I was super stressed for my podcast with you John And I didn't know what I was gonna talk about. I was like so stressed about the words that were gonna come out of my mouth I could take just a quarter of our tro com and just take down the notch a little bit Take that edge off and then I'm gonna perform perform better. On my podcast, because the words are going to come, they're going to flow. I didn't need that for you today. I knew we'd just have a nice conversation. But in general, it's a way to come down and just decrease the tension in the system just a little bit, take that edge off. Or if you need more of that, you take a half or you can take a full of the trophy to really get that stress to come down and lose a little bit of the focus in the process, but that's not necessarily a bad thing if you just

want to relax. And we've affected the GABA system here in a couple of different ways. So GABA is your most important and the most pervasive around your brain that's doing the work to decrease the firing of your brain. And it's inhibitor and neurotransmitter. So GABA is made from glutamine. So glutamine is amino acid. And then this amino acid glutamine gets

started to glutamate in the brain. Glutamate is an excitatory neurotransmitter. And then glutamate is transferred from glutamate to GABA in the brain, OK? And just to give a quick rundown of that. So increasing glutamine in your food may not be great if you can't convert into GABA very well, but that's a whole other long story So don't just pound glutamine if you hear this it may not be helpful for you

So but it can be in some people, but anyway, so there is Kava in the formula Kava has been around a long time It's a GABA ergic formula, which means it increases GABA in the brain. So Kava is a South Pacific Islander Plant and it's a root plant that's been around for thousands of years for help with calm relaxation that increases GABA in the brain. So, GABA is a South Pacific Islander plant, and it's a root plant that's been around for thousands of years for help with calm relaxation. GABA also causes a little bit of numbness. So, when you take trocom, you're gonna feel a little bit numb and tingly

for about five or 10 minutes, and it's gonna go away, just so that people are prepared for that. Then in the form of this, also something called nicotinol GABA, which is vitamin B3 attached to GABA itself. This makes your GABA more permeable across the blood brain barrier.

So a lot of people think GABA supplements. Unfortunately, they do very little because very little GABA actually gets across that blood brain barrier and gets into the brain itself, increasing GABA. So we use B3 attached to a GABA. Vitamin B3 gets through very easily. It's also something that helps in a hands-brain function

because vitamin B3 turns into nicotinamine, ribosides, nucleotides, or NMR. Those things that people are taking, it turns into nicotinamide, and so that's something that helps with energy production as well. So a lot of people are taking NMR and R these days and things like that. And NAD, excuse me, that's the other one I mentioned.

So B3 turns into NAD directly is what I meant to say. So, anyway, so you have that in the formula. And then we have CBD and CBG. CBD, everybody knows these days, CBD affects what's called the body's endocannabinoid system, that's system in our body that maintains homeostasis basically. But it also affects the GABA system as well. And then CBG is the same thing.

It works in the same mechanisms, but also some additional ones that are awesome metabolic, helping with pain, helping with temperature. So, so excuse me, a very cool, a very cool formula. I love CBG actually. So, if these four compounds at very low doses that will turn off your anxiety and stress in 15 to 30 minutes when you dissolve it in your mouth, basically. And depending on the dosing, it can give you just take, take any edge off, or it can be something that really helps you relax. So for me, the way I use TORCOM is in my type A personality that my brain won't shut off

sometimes at night, I can use it to help quiet my mind and help me fall asleep at night. So in patients, and I use it in a lot of my patients the same way as well. Okay, well, fascinating stuff. And I did want to go a little bit deeper just into trokeys because why did you decide to use them as the delivery method instead of capsules? I felt that there's a long track record of using trokeys actually and we've been using trokeys in medical practice for decades. Oftentimes they're used for hormones and they're using it now for ketamine as well, and oxytocins, another hormone that's used in a trokey form.

Dr. Ted and I, and we have Dr. Harry and Dr. Shaker. There's four docs in the team, including me and a number of professionals. We have all used compounding labs that have made trokeys for decades. And so we knew the safety profile. We knew the absorption profile. The cool thing about a trokey, it's this dissolvable laws in jazz I was describing that it goes between your upper cheek and gum

and dissolves over about 15 to 30 minutes. You can swallow these on an empty stomach, as I said, but it does work faster, especially our blue canotine, our focus formula, and our trocom, our anxiousness formula. They work better if you dissolve them their mouth, is it gonna work faster?

The pure blue, the just blue, that one can be swallowed and mitochondrial benefits are about the same. Okay, but the beautiful thing about the mucosa here is it's highly vascular and it drains directly into the brain circulation. And so you get significant brain circulation of the compound very quickly.

And it also bypasses something called first pass metabolism in the liver. This is how we digest everything, whether it be supplements, food, everything goes through your stomach into your small intestine and then gets into the circulation of your liver to help with processing. And most supplements that we take orally have pretty poor bioavailability, which means how much of that supplement active part of that supplement are actually getting into the body itself. So the example I like to give is one that I use a lot actually, an acetyl cysteine or NAC for short. This is a compound that's 10% bioavailable, which means you

would take 100 milligrams of NAC, you're only getting 10 milligrams of that into your body. So the beautiful thing about a trophy is that it bypasses all of that. So all of the ingredient just about are getting directly into your circulation without being deactivated by your liver. So that's the other reason why we use trophy. So they're fast and the ingredients do not get deactivated by your liver.

The trophy itself is easy to titrate so you can take a quarter of the tablet or the trophy or a half or a full. The problem with a lot of capsules out there these days is that you get a capsule and for me I'm sensitive to things. I can't usually take the photos of something and then I'm like like pouring I'm pouring around like I'm taking the capsule out I'm undoing the capsule and pouring out half and it's just a mess. And often with methane blue as well, people are getting in liquid form, and the liquid form is just a disaster to work with, is it gets everywhere. And just for warning, for people that are interested

in trying, methane blue does work as a stain, so it will stain. And it stains your mouth for a little while, that goes away. But it will stain clothing, it'll stain in your sink, as well, if you're using the liquid, so you have to be really careful with it and how you're utilizing it So like a lot of the people that we work with especially in the beginning when we started the company We're using liquid methylene blue because it's liquid methylene blue has been around a long time

But it's such a hard thing to dose and it gets everywhere So and then the other problem with it is that it's very difficult for you to get good Pharmaceutical grade products and so that's the other reason why we went with trokeys. We knew we could get good pharmaceutical grade ingredients, including methylene blue, and just be really careful on the titration of those and making sure every trokey was the same amount. You probably know this job, but you know, supplement companies, they do not regulate themselves, nobody regulates supplement companies. And so you rely on the supplement company to do their own testing or have third party testing. So everything that we do at our company is pharmaceutical grade or it's been tested by third-party labs and we have certificates of analysis for our ingredients

for all of our products because I wanted to use this for my patients and for the people that I work with using hyperbaryc therapy or health optimization medicine. Like it's all about making sure I'm giving things that are safe and effective and knowing that we are giving the consumers the best possible products out there that we can, no matter which ones we're using here. But methylene blue, especially for those that are looking, you've got to be really careful because there are a lot of products out there and they may not be pharmaceutical grade. And methylene blue is still used in fish tank cleaner. Please don't use fish tank cleaner,

and when you don't drink it, we had some actually very funny click bait headlines from our company back in like 2021, when it was basically the headline of the article was biohackers using fish tank cleaner to reverse their age, which was great. It's a great headline, but it's, and they're right that

methylene blue is still used in fish tanks. It's used actually to treat fish that have infections actually. And you don't want to use methylene blue from a fish tank store, because that fish tank methylene blue is going to be contaminated with heavy metals. Okay, so use pharmaceutical grade, make sure you're getting methylene blue that's tested very well before you take it. So. Well, I'm glad you went into some of those safety precautions and how you make the product because I did want to ask

there are a growing number of new tropics on the market like no cube, no septin, neurogum, mind lab pro. How do your products differ from them? There are a lot of new tropics. That's a great question. I think that the key really is going first to the classifications, right? Understanding what kind of new tropic you're taking. Are you taking a new tropic that's going to help your brain perform a task better, but not necessarily healthy? Are you getting a new tropic that's going to be healthy? Are you getting a one that could be a combination that's supporting your system at the same time as helping you perform a task better?

So you have to know what the ingredients are in these things. And then also you have to know what is your baseline health already. So are you clocking a system that doesn't have any money in it? Are you trying to put money into the bank, but there's no bank there, whatever analogy you want to give? So what I found is that if you're taking things like that are going to stimulate the bank, but there's no bank there, whatever analogy you want to give. So what I found is that if you're taking things like that are going to stimulate the system, like caffeine or nicotine, for example, on their own, they're great new tropics. But if the brain is already under stress, it's going to cause problems over time. So what's different about our products, I think, is that, well, I know, is that we're not only looking at it from perform a task better, but we're also looking at how we supporting

the brain to function better and to be healthy and to be protected at the same time. Methylene blue is neuroprotective. Nicotine is actually neuroprotective at low doses. It's been studied this way. It's been studied in Alzheimer's patients. It's been studied in mild cognitive impairment. So we know that this is a case. We know CBD is neuroprotective, right?

But we do know that caffeine, probably not neuroprotective, maybe, but probably not over the long term. So what are the benefits of caffeine over the long term? They've talked about longevity with caffeine too. It's probably the polyphenols in the coffee that are probably the protective part of it. Maybe the caffeine, nobody really knows. But I can tell from personally that

caffeine doesn't work for everybody and over time it may cause trouble for people and certainly it was the case for me going through medical school and residency and it didn't realize how much I was drinking what I was doing and then I had to you know stop. When it comes to other products out there, I think that they could be beneficial. I mean, a lot of these companies the key is just to understand how you're using the products and why you're using the products and what the ingredients are in them and how they're going to affect you. And maybe you're okay to take something with high dose for a short period of time, but over a long term, it may have significant a detrimental effect as well. So I think the key differentiators for us is that number

one, we're making these products to not only be helpful to the brain so you can perform tasks better, but we're also supporting the brain at the same time. And number two is that we're doing this in the context of, I really hope you don't need my products all the time. Actually, I really hope that you can optimize your health and do things foundationally, as we talked about in the beginning with the nonprofit organization and training doctors and practitioners, like, I want you to find a practitioner that can help you optimize so you don't need these things all the time.

You don't need blue canteen to help with your focus because you're doing great, or you don't need Trocom because your GABA system is working well, your neurotransmitter systems are optimized, your amino acid levels are great. So you don't need extra Trocom, you don't need Trocom except for maybe every once in a while. But in the beginning, you made these things more often because you need more help. And that's okay. But over the long term, the goal we do donate a part of our profits to the nonprofit organization as a way to help continue to train doctors. We're early, we're new, but we really do think that we can move the needle on healthier, John, in a different

way that's been done before. And it doesn't take the place of functional medicine, doesn't take the place of conventional medicine. They all are important and not mutually exclusive to what we do. It's just the foundation here. Then you can use these compounds or formulas to help along that path of optimizing your health. And we call them like your cheat codes for democratizing enlightenment is like our fancy way of saying, these are ways that you can just help optimize your path of just trying to be a better person,

trying to show up in this world, try to reach your true, you know, human potential. That's what we're looking to do with these compounds. But alongside donating to a nonprofit, training doctors, optimizing health and doing it that way. I don't think there's any companies out there that are doing what we're doing because we're doing that at the same time. Okay, and Scott, are there any individual factors such as age that influence the effects of new tropics? It's a good question. As I was alluding to before, when I was talking about the practitioners, I was speaking to before our call today, that had really significant effects of using the pure methylene blue or just blue trokeys without nicotine and caffeine, but it gave them that same effect.

They felt focused. They felt drive. They felt concentration for three to five hours. These are ladies that are on their feet. One was a chiropractor and she's, I feel great, but she doesn't drink caffeine, typically. And so you have some people that are just going to not need as much as others that will need more. I found that like our huge bodybuilder, lean mass dudes and women, they need more to have the same effect. They're just very highly metabolic, and they just burn through things faster in general.

So there's gonna be individual variability. In some people, it's gonna be the just blue, in some people be the blue canteen, for example, you just don't know. So what I can say though, I guess, is that if you have more chronic inflammation, if you have more way to go, let's say, in the sense that you have a long way to go

until you feel like your health is optimized. Oftentimes you want to start off at a lower dose of our products and titrate up slowly over time, as opposed to starting at a higher dose. And what I would typically recommend if somebody is very sensitive or has chronic inflammation auto immunity infection, post infection, post COVID, those kinds of things, starting off at a low redose, like a four or eight milligram trokey of just blue and not start off with blue canteen, which has got nicotine and caffeine in it and stimulants, which is maybe too much for the system too soon, for example. So I think that the variability depends on how well optimized you are to start off with, honestly. And if you're not as well optimized, then typically starting off with lower doses of non-stimulant compounds is probably a better idea.

And then slowly working yourself up. That's not across the board. Another great example is that we have tons of paramedicals of women who take blue canotine because of the brain fog and the fatigue and the hot flashes and the poor sleep, they tend to be able to function very well using blue canotine as a stimulant. As a way to help them decrease the amount of coffee they're at the drinking. The nice thing about blue canotine only lasts four to six hours for the most

parts, you can take a little bit later in the day. So various kinds of things, but I think there's obviously going to be interperson variability. And obviously, from my perspective, is that I try to measure what people need and understand what their system looks like ahead of time. And then I can say, okay, this is what you need now versus this is what something we can work on later. But the beauty of methane blue is that can be added to the process almost at any time, no matter how sick people are. Oftentimes, it can be added. We were keeping people out of the hospital early in the pandemic, at least clinically, not the company, myself personally. And this is still the case now. We're using it for brain fog and fatigue. And so you can use this in a lot of different ways very early on in the processes of these kinds of things and see significant benefit. And if you weigh 400 pounds, it's easy to take off weight. The difference is very quickly.

And so this often happens with methylene blue. If you have a longer way to go, you can see benefit much faster. I've seen people that like two days after starting taking methylene blue, their joint pain goes away, their brain fog goes away, their blood pressure gets better. And so you have, and if blood pressure is elevated because of inflammation specifically. So it's very fast in some people what you can see. Okay, and then the last question I had for you, Scott, is, can you discuss any scientific research or studies that have been conducted on the effectiveness of this and its impact over the long term? Sure. So there is a really great researcher and he's on some podcasts as well. His name is Francisco Gonzalez Lima, and he's at the University of Texas, Austin. And he's done a lot of the

seminal work, the groundbreaking work, on methylene blue in a cognitive impairment model. And so he's done lots of work with animals, especially, but he's also done some great papers on the combination of methylene blue and red light therapy specifically, because red light therapy is synergistic with methylene blue. They both donate electrons or photons in light's case, but they both help with energy production by making complex four of the mitochondria work better. We have a lot of people that are using our products that will take methylene blue, and then about 30 minutes or an hour later, going for the red light panels or going out in the sun. And it's really a fantastic synergistic tool

to combine those two things together. And so you publish a nice study, it's on our blog, if people go to our blog at triskriptions.com, and you can go to blog and search for red light, and there's a great blog that we wrote about meth-lein-bleu and red light for neuroprotection. Dr. Lima's work there has been really profound.

There's also been studies with using brain imaging at looking at a visual spatial recognition and memory in humans. And there's also been a lot of early groundbreaking work in depression, in bipolar, and other mental health issues as well. There's some clinical trials that are going on right now. As I was mentioning earlier,

oftentimes it's not methyleneblew directly. It's derivative drugs that are billion dollar potential blockbusters and not something that's generic. There's also a lot of interest in methylene blue directly. It's derivative drugs that are billion dollar potential block busters and not something that's generic. There's also a lot of interest in methylene blue for COVID and there's been some ongoing studies there both for COVID infection in post-COVID syndrome. So that's ongoing research.

And there's also research that's being done in traumatic brain injury and stroke and other neurodegenerative conditions as well. We have parents that give it to their kids with autistic spectrum. On the spectrum as well, seeing some benefit, that's all very clinician driven. It's not driven by our company, it's driven by clinicians that are interested in our products. We have clinicians all over the country that wholesale our products in their offices, and

so that you can go to their offices and get consults about meth and blue and about the other kinds of things that we're doing, is there using these things in their practice? And that's one of the main things that I had at the company is practitioner education development. I create webinars for everybody with all the latest research that on our products. And then I do interviews with our practitioners.

And that's what I was doing just before this interviewing or practitioner on how they're using it in clinical practice as well. So it's not a compound without research. It's been around forever. And so it has a lot of research, but the research in the neurocognitive side is within the last decade and very exciting. Scott, now that we've gone through all this information, I am sure the listeners are interested. How can they get their hands on this product? So I was wondering if you've had anything special you wanted to offer the passion struck community.

Of course, John. So all you guys have to do is go to our website, choicecriptions.com, and put in code passionstruck for 10% off your order. And that's all you need to do. And you can get anything you'd like. We have also subscriptions as well, which I'll also allow for the 10% off, which is pretty cool.

We don't typically do that. So if you're looking to get a subscription and buy it regularly already, this is a great way to start doing it along with the 10% off your order. So I really hope you guys give it a try. I think it's a really nice website that we've developed that is there's a lot of information. We have a really great blog that I've been curating for a long time. That has a lot of information. And so the practitioners on the team, including me, are also on the help desk

helping with questions and concerns. And we really do care that everybody has a great experience and that everybody has their questions answered. I didn't get into this to sell products, John. I got into this whole medical field to really help people, obviously. And the reason why this resonates to me so well is because it's just the framework that we're using it in, right? Optimizing your health, getting help along the way with practitioners with products with people and that's really the foundation of everything really is that it takes the village, right? It takes everything together to truly do that and create the longevity that we all hope for. Scott, thank you so much for joining me again. What a fascinating discussion.

I appreciate it, John. Thanks so much. I thoroughly enjoyed that interview with Dr. Scott Sure, and I wanted to thank Scott for the honor and privilege of coming back onto the podcast. Links to all thanks, Scott, will be in the show note to passionstruck.com. Please use our website links if you purchase any of the books from the guests that we feature on the show,

all proceeds go to supporting the show. EverTiser deals on discount codes are in one community at place at passionstruck.com slash deals. Please consider supporting those who support the show. Videos are on YouTube at both passionstruck clips and John R. Miles. As I mentioned at the beginning, we are now on the AMFM247 National Broadcast, where you can tune in on syndicated radio every Monday and Friday from 5 to 6pm Eastern time.

Links will be in the show notes. I'm on LinkedIn, where you can sign up for my newsletter, or you can catch me at John Armiles on all the other social platforms. I also wanted to mention that my book is now available for free sale. Links for that will also be in the show note. You are about to hear a preview of the PassionStark podcast I did with Julie Flushman, CEO and president of the Pancreatic Cancer Action Network. Otherwise known as Pancan. Pancreatic Cancer is one of the deadliest forms of cancer, with a five-year survival rate

of only 10% making it the third leading cause of cancer deaths. Julie joins us to give us the latest advancements on Pancreatic Cancer and updates from Pancan. An episode you absolutely do not want to miss if you know anyone who is suffering with this steadily disease. One of the strategies that Pancan did in the early days when we also had less funding was funding junior investigators. That by encouraging junior investigators to look at and think about pancreatic cancer, ensuring that they stay in the field and that they become sort of our future superstars.

And that's exactly what's happened. I mean, at this point, Pancan is funded over 130 junior investigators. The people that we funded in the early days are definitely the superstars leading the pancreatic cancer research labs around the country. And that strategy really did work. The fee for the show is that you share it with family or friends when you find something interesting or useful. If you know someone who wants to learn how to become limitless, then definitely share

today's episode with them. The greatest compliment you can give us is to share the show with those that you love and care about. In the meantime, do your best to apply what you hear on the show so that you can live what you listen. And until next time, go out there and become passion struck.