Radiolab - Staph Retreat

Episode Date: March 8, 2024

What happens when you combine an axe-wielding microbiologist and a disease-obsessed historian? A strange brew that's hard to resist, even for a modern day microbe.In the war on devilish microbes, our weapons are starting to fail us.  The antibiotics we once wielded like miraculous flaming swords seem more like lukewarm butter knives.But today we follow an odd couple to a storied land of elves and dragons. There, they uncover a 1000-year-old secret that makes us reconsider our most basic assumptions about human progress and wonder: What if the only way forward is backward?Reported by Latif Nasser. Produced by Matt Kielty and Soren Wheeler.Special thanks to Steve Diggle, Professor Roberta Frank, Alexandra Reider and Justin Park (our Old English readers), Gene Murrow from Gotham Early Music Scene, Marcia Young for her performance on the medieval harp and Collin Monro of Tadcaster and the rest of the Barony of Iron Bog.Our newsletter comes out every Wednesday. It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)!Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [e-mail] support for Radiolab’s science programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simons Foundation Initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Hey, I'm Latif Nasser. Today I'm going to play you an old episode that I reported way back in 2015. It's got science, it's got miracles, it's got Vikings, it's got a potentially hazardous kitchen experiment performed by senior producer Matt Kilty and I. And what I really love about this episode is how it makes you see progress, not as a straight line. Not sometimes not even as a line at all. Sometimes it's actually a circle. I swear it'll make sense at the end of the episode.

I now present to you Stafford Treat. Wait, wait, you're listening. Okay. All right. Okay. All right. Okay. You're listening to Radio Lab.

Radio Lab. From WNYC. Okay. Yep. Rewind. Okay, I'm Chad Abramrod. I'm Robert Krollwich. This is Radio Lab, and today...

Well, today... Yes. The story of an ax-wielding nun coming through a window to smack some Staphylococcus and take you back to the future. Exactly. The story comes- Does that make any sense? I don't know. Well, I will.

I will. The story comes in two parts, both from our producer, Latif Nasser, and here is part one. So, the way the story goes, it starts in 1928. 1928, Alexander Fleming, the story goes, it starts in 1928. 1928, Alexander Fleming, the story goes, who knows if it's apocryphal or not, is growing staph, staphococcus, in his lab. That's Mary McKenna, she's a science writer, and staph is a bacterium.

It lives on our skin and it especially likes parts of the body that are warm and damp. So it likes to be just up our noses or... In our genitals or in our armpits, places like that. And generally it's no big deal. Doesn't really do us any harm. But if it gets into a scratch or a cut and makes its way inside our bodies, staff goes from being this benign companion

to being potentially deadly. Anyway, London, 1928. Fleming his growing staff in his lab. In these little petri dishes. And he was a slob, basically. And he goes on a vacation, leaves his petri dishes, covered in bacteria, just around, leaves his window open, and something blows across his lab plates. Some tiny little speck of a thing just floats in through the

window and comes to arrest on one of those Petri dishes. And so a few weeks later, Fleming, finally back from vacation, he needs to use those lab plates again and he and his assistant go to clean them off. I mean, you'd imagine that he would see some real lush, nice, furry lawn of staff just overflowing right out of the plate. Because it's been sitting there for so long. It's been a staff party. But on one of the plates that they pick up, they realize that it's almost polka dot. It's got little dead zones all over it little patches where the staff is dead

Dead patches does something blew through the window landed in the dish and starts killing the bacteria Yeah, and so when Fleming looks down at his plate He sees that at the center of these, you know, staff dead zones, there's a tiny speck of natural mold. And they realize that that mold is expressing a compound that is killing the staff around it. It's like emanating rays of death. What was the compound?

That compound was called penicillin. The first true antibiotic. compound was called... Penicillin. The first true antibiotic. Infectious diseases that had been killing people for as long as we had been people suddenly could be stopped. And it just blew in through the window? That is the story that's always been told. However it got there, it was amazing. It was a miracle.

It was called a miracle drug, right? It really was a moment when the world changed. mean, it was just, it really was a moment when the world changed. When Fleming was put on the cover of Time magazine. This is 1944, height of World War II. It was a picture of his face and the banner on the cover said, his penicillin will save more lives than war can spend. But, and this is, I had no idea about this. Virtually at the exact same time when Fleming's face

is on the cover of Time Magazine, like two months later, this Stanford researcher publishes that he has found five different strains of staff that do not respond to penicillin. Really? Yeah. This is happening while he's on the cover? Virtually the exact same moment. And it's the first sign that staff has responded to the penicillin in the world by developing resistance. It's almost like a......Separateus or Soren Wheeler. The era of penicillin was over before it began. Almost before it began.

Before it's even released to the general public. Wow. And that penicillin-resistant staff moves across the globe. And in 1957, in Cleveland, some scientists gather together. And they are in a panic. They have no idea why they've lost the antibiotic miracle so quickly.

So scientists across the globe put their brains together and try to come up with a new drug. The next amazing thing. And in 1960, they get it. Methicillin. Oh, no, no, no. And it works. For about 11 months.

11 months? Wow. And so we started this arms race. There was a bug, and then there was a drug that took care of it, and then there was a better bug. Drug bug, drug bug. Right, exactly. Actually found this list.

Do you want to hear it? Yeah. OK, so Streptomycin, 1943, Resistance 1948. Methicillin, 1960, Resistance 1961. Clyndamycincin 1969, resistance 1970. You can think of it as sleep frog, or you can think of it as a game of whack-a-mole. Ampicillin 1961, then 1973.

So that's a little. Carbenicillin, release 1964, resistance 1974. They're getting better, they're getting better. There were always more drugs. Drug development was doing really well for a really long time. Hyperacilin introduced 1980, resistance 1981. But after the year 2000, drug companies begin to realize it's not really in their best interest to make antibiotics anymore.

And the end I have on this list is Linazolid, which is introduced 2000, resistance 2002. Wow. There are a few more, but you get the idea. uh, Linazolid, which is introduced 2000, resistance 2002. Wow. There are a few more, but you get the idea. Antibiotic approvals, the entry of new drugs to the market, just kind of fell off a cliff. Why? Well, it takes 10 years and a billion dollars to get to the point where the drug is marketable. But as soon as you get the drug on the market...

The resistance clock is running. So you probably won't make your money back. And as you've probably heard, we now have these situations. Well, frightening new warning from the Centers for Disease Control about the spread of a string of germs where literally nothing works. So-called superbugs are now turning up in hospitals

and the patient dies. There are now bugs that can resist all of our drugs. I have seen physicians break down weeping over this. It's not the way that medicine is supposed to fail anymore, but it does. I mean, I know that possibly the origin story of penicillin is apocryphal, so this is all a little suspect, but just to enjoy imaginings for a moment,

like it just seems like if that happened, let's just open up a bunch more windows. There's something not a blow in. But we could wait a long time, right? I mean, we had staff had been around for millennia before 1928. But you know, the whole reason that I wanted to do this story is because kind of there is a new window. It's a different kind of window though. It's not a window next to some petri dishes.

Not a window next to some petri dishes, kind of a window next to some petri dishes, but a totally different kind of window. What kind of window is it? Well, I'm about to tell you that. Is something blowing into the window? Yeah, but it's not mold. It's way more fun than mold.

It carries an axe. How about that? So it's a person, maybe. I don't know what I'm referring to anymore. Part two? Yeah. Okay, hey, I'm Jed Abumrod. I'm Robert Krolwich.

This is Radiolab. We're ready now for part two. Now remember when part one ended, there was a window open and something was going to come through. We don't know what. We know it's not mold. Yeah, we know it's not mold. So whatever it is, whatever it was, whatever it will be, we will hear about it now from our reporter, Lot of Nasser. Well, actually there is this story about these two women who did open a window

to an alien and distant land. And actually in a way it's a story about reimagining the past, but to me it's a to an alien and distant land. And actually in a way it's a story about reimagining the past, but to me it's a story about a friendship. Hey everybody. Hello again. Hello again. It's a story about an unlikely friendship.

It's a buddy film. It's a buddy movie. Okay, so yeah, maybe just walk us through it. Right, so okay, so you have... Hello, I'm Dr. Christina Lee. Christina. And I'm an associate professor in Viking Studies at the School of English at the University of Nottingham. She's a historian.

And then you also have... Hi, I'm Freya Harrison. Freya. I'm a research fellow in the Center for Biomolecular Sciences at the University of Nottingham. And Freya, Freya's a microbiologist. She studies bacteria. We'll start with her. Okay. So most of my work is about sort of looking at how bacteria evolve during very, very long-lived infections. But my big hobby is Anglo-Saxon and Viking reenactment. is Anglo-Saxon and Viking re-enactment. So I had purely amateur interest in the history

and mainly in dressing up as a warrior and going to fight club every Wednesday night and learning to use the weapons. Really? Yeah. So this is actually not Freya's group. This is a group in New Jersey, but basically they do the same thing.

Hundreds of people go out into some field with some dulled weapons. Everything from swords, spears, axes, and we give each other a jolly good bashing and have a good time. I only mentioned this because it actually plays into the story. Well, it was really nice sort of coincidence, really. 2012. A few years after finishing her doctorate, Freya goes off to work at the University of Nottingham. Nottingham's one of the places in the UK,

not only for microbiology, but for Anglo-Saxon and Viking history. And she goes there to study microbes, but she figures, hey, why not while I'm here, brush up on my old English? With her, it's a wolf here, it's a buddhista. I'd studied some old English to a level where I could sort of read and speak a little bit.

That's standard nix nixta. But she figured, hey, she could be better. And if she did, she would get deeper into the whole reenactment thing. So I rather cheekily emailed the School of English's Old English Reading Group. That's where she met Christina. Yes!

The historian. At one point, Christina the historian asks Freya, like, what do you do? And Freya said, you know, my day job is that I'm a microbiologist, but on evenings and weekends, I'm a history nerd. And Christina said the moment she heard that. I just kind of thought, I found my kindred spirit here. Because she was like, wow, I'm like your mirror image, because I'm a historian by day, but by night, I'm a microbiology nerd. I've been interested in infectious disease

for quite a long time, which I don't find any kind of friends in my department. She told me she's the kind of person who would watch Ebola coverage on the news and not be able to stop watching. So eventually they start talking about historical diseases. So like, how would people back then have treated something like, you know, Ebola? Freya is especially interested in this because she, for her historical reenactment, is developing this nun character who goes off and heals people.

But anyway, so they're talking back and forth, and then to cut along the story short, they find themselves both interested in this one particular book. It's known as Bald's Leech Book. So this is about 1100 years old. What's it called? Bald's what? Bald's Leech Book. It's nothing to do with no hair.

Oh. Even though it's just speth. Ball, is it B-A-L-D? It is indeed. And leech, like a leech like a little worm that grabs onto your, and sucks your blood. No, no, it comes from the old English lecher, which is actually a healer or a doctor.

So the little squiggly animals are called leeches because they're medicinal, not the other way around. Oh. So the doctor wasn't named for the leech, the leech was named for the doctor. Exactly, yeah. And Bald is the man the guy wrote the book? We think it's a guy, we think it's a guy's name. And what is this book? So it's kind of like this old healer's handbook. It's filled with these potions and cures. The original manuscript is in the British Library.

Locked away. But 21st century, very kind people have digitized the original old English text and put it online. So Christina and Freya bring it up and they start going through all the remedies. And, you know, it describes to you remedies for stuff that is a little bit different, you know, things like... Thone deovo, thone manano. Possession by the devil. Which according to this leech book, the remedy for someone who is possessed by the devil is you

Spure drink and loot re. Make this kind of like foul brew, you make them drink it and it'll make them vomit out the devil. And then there's another remedy for warts. Be shea op weirth, ye knua to somne. And all I'm gonna say about that one is that it involves hounds urine and mouse blood. And then things like... How should we say make your husband more physically attentive?

Or less physically attentive? Whichever direction you need to moderate it. Higgs blood I hope. Or toad blood. Drink on neachtacht nest yeah, actually It's just you boil a plant and some water and give it to the guy. Oh, yeah anyway So free and Christina are going through this leech book looking for some kind of wound something that was clearly an infection some posse Something we could clearly say that's that's bacterial and eventually they find an entry where the end of the recipe

It says in old English say betz the latch a dog So bets the latch done The best medicine the best medicine hmm. Yeah move over laughter. Yeah, and we thought how can we not try this one? What was the best medicine for so it said it was for a lump in the eye. It's actually called WEN in the olden days. Yeah, these days if you get a, of course that could be something like a wart, right? But there is a suggestion by archaeologists that eye infection was rife amongst the Anglo-Saxons because you lived in buildings where you had smoke going on, you lived crammed together.

So it could also be a sty. What is a sty? It's an infection of an eyelash follicle. You rub it and it itches and then it gets swollen. It causes quite a nasty red lump. It's a sty in your eye. Sty in your eye. Now it just so happens that the bacteria

that causes the sty in your eye is- Staphylococcus aureus. Staph. Oh, the same stuff as the Mr. Window Man, Penicillin Man Exactly And we just thought, wouldn't it be nice to have a bit of spare time and earn a couple hundred quid to buy the ingredients and just give this a go? Yes! Let's give it a try, you know, why the hell not?

And matter of fact, look at this place! We thought that too Studio Not bad at all Look at this place! We thought that too! Not bad at all. Recently producer Matt Kilty and I went to my tiny apartment in the city and we tried to cook it up too. Are you ready to cook?

Oh I'm ready to cook. I've got this recipe here. Awesome. Yeah, yeah, yeah, please read it. Go for it. Okay, it goes like this. We recommend. Ice cream.

I see all of that with one, and you name croplier. That's the first line of the recipe and right off the bat for Christina and Freya there's a problem. That first ingredient was a second ingredient, garlic, which is an allium species, and crop liach. We know this was another allium. That's what the dictionary of Old English tells us. So they figured probably what they were dealing with was an onion or a leek. But we didn't know which one.

So we thought, OK, we'll try one that has onion and one that has leek. But yeah, yeah, I'm fair, love. Now, the recipe doesn't cover this, but we did it anyway. Peel the onion, chop it up. Ooh, the same for the garlic. And the recipe doesn't tell you how much. It does tell you equal amounts off.

So you take out the measuring cups, you measure out equal amounts. Yeah, equal amounts. And there's a pestle. And then after that. OK, it says. The canoea well. The big to somne.

Pounded well together. Okay. You have to be really pounded. And pounded fraiade. Yeah, yeah, so lots of time with the water on pestle. Mussels built up from wielding a sword for pounding the ingredients. Look, it's starting to be more of a mush. Third ingredient? The next one was definitely something you wouldn't have knocking around in your kitchen. And fae ar es, ye al an bea em fella.

Ox gall. Ox gall. Bovine bile from a cow's gall bladder. What do you have to kill the cow and then go reach it? No, it's actually a very standard ingredient in microbiology labs. Ox bile. Today in 2015, you can but should not just buy it on the internet. Here we go, here we go.

Until you take the ox bile, add it to the onion and garlic and then the fourth ingredient a name of wean wine and wine time red wine white wine well this is the thing so we had quite a discussion about what type of wine should we use and we don't know really did they have red wine did they have white wine what was the alcohol content but I did a bit of detective work and she figured out that the monastery where this leech book was written, well, she figured out where their vineyard was. And just down the road there's this modern organic vineyard.

So they used that wine. C'e v'ghiole. C'e v'ghiole and figli. I just want to point out how difficult it is to find the English wine. We had to use Italian. But. And make me with, su, la c'e dò, fone an ar fat. Once you get all that stuff together, you're under the final ingredient.

The fifth ingredient was actually that you're specifically told that you have to mix these ingredients together in a brass or a bronze pot. I don't have one. So we had to sort of add pieces of copper that would have been available to people at the time. So they had to do some research, but they figured out that the copper of today that is most like the copper of a millennium ago was actually cartridge brass, which is what's used as standard in plumbing fittings.

Drop a few pennies in there. We actually use pennies. Do I stir it? I think I stir it. It's like a World's Worst Cooking Show. It looks and smells like quite a nice, quite a nice summer soup. Oh, it looks awful. Oh quite a nice summer soup. Oh, he looks awful. Oh, that's so gross. Clearly we botched this whole thing. Let us stand the neon nicked on them, Arfata.

And finally, so we're gonna cover it. Okay, we're covering it. The directions say we have to let the whole thing sit for a while. It has to be stored for nine days and nights. Okay, that's it. One day goes by two days, three, four, five, six, seven, eight, nine. All right, nine days later.

All right, here we go. You ready? All right, here we go. And then you have to strain it through a cloth. The liquid that comes off, you apply to the person's eye. Or the liquid. And um, nigt do med fedare. Yeah, with a feather.

Med fedare. Se betstah lachadom. Now clearly we didn't have any staff to try this out on, but Freya in her lab, she made these mock wounds. Freya- With these little plugs of collagen, so it's a bit like jelly. Josh- Basically it's like a goopy substance made to be kind of like a flesh wound. Freya- And we infect these wounds with bacteria with the staff. Josh- Then they put this thousand year old recipe that had been standing there for nine

days, they put it on the bacteria that was in the fake wound. Freya- We obviously were, we didn't think this was going to work. No. We thought, you know, given the ingredients, we might see some small killing effect on the bacteria, but it won't be anything to write home about. They thought maybe it'd kill 10%, 20% of the bacteria. But then when they came back the next day...

It was a staff massacre. It went on a rampage. It went on a staff rampage. It was killing, you know, 99.9999% of these bacterial cells. What? Yeah. At first we thought we'd made some sort of mistake and this was some kind of fluke, you know, we'd accidentally mixed up our plates or mislabeled something.

So they run the entire experiment again. They grab the ingredients, mash them up, put them on some bacteria, and it happens again. Just absolutely wiped out the bacteria. Killed them dead. And you take wounds. Then they try to third time and a fourth and a fifth, and it works every time.

And this is just something you really don't see in your career as a microbiologist. And eventually, they escalated from just regular staff to DeMersa, to the methicillin resistant staff. And this is one of the bad ones. The super bug, new government data estimate that about 2,000 people are dying of community-based Merca every year.

This one is very dangerous. So Christina and Freya, they sent some of Bald's brew to one of their collaborators in the States. Our collaborator, Kendra Rumbau, in Lubbock, in Texas. Kendra took the stuff, put it on some MRSA bacteria, and then a week later sent Freya and Christina an email. And I think it was actually a three-word response. I think she just simply said, What the fuck? What the fuck? What the fuck? What the fuck? Bald's best medicine had just wreaked havoc on the Mercer.

It killed 90% of them. This is beyond our wildest dreams. Now, Fray and Christina made very clear that this is not yet a miracle drug. I mean, it's not even being tested in humans. So absolutely do not do this at home. They don't even know if this is safe. It might be that if you don't do it in exactly the way we did,

nasty fungus could grow in it, give you a worse infection. So we should not have done this. Math and I, we dumped our stay down the drain. But the thing about this whole story that is so intriguing and so cool to me is this time travel thing, which is so strange. Like it's like the idea that something a thousand years ago,

like a bullet forged a thousand years ago, we could use it now and then it could work. The time travel dimension of that is so weird to me. It kind of makes you think differently about, I don't know, progress. So, without much further ado, Dr. Christina Lee and Dr. Freya Harrison, and they're going to talk to us about some ancient biotics. For example, just a few weeks ago, Freya and Christina got up in front of the Royal Society of Chemists. Thank you very much, and it is an absolute pleasure to be here. Large hotel conference room, 100 or so people.

Freya actually got up on stage just as a nun. Okay, so this is one interpretation of what an Anglo-Saxon scientist may have looked like. And they presented the results. Next ingredient is particularly- They did the cooking demo and then at some point, Christina said something really interesting. She was like, okay, sure, we want to write this off because it has demons and dragons

and elves in it. But are we sure that we know what they meant by those words? Like, for example. There are remedies which ask you sing for avamarayas. And we would say, oh, that's so superstitious, this is all in their heads. But there again, we should also remember, this is a period when people do not have watches. You do not have your nurse, you know,

so that's got the watch. Everybody knows the avamarilla. Everybody knows the length of an avamarilla. So maybe it's, maybe it's take this medicine and wait 20 minutes, and I know how to standardize 20 minutes, which is- Three avamarillas, four avamarillas. So, it may appear one way, and it's, in fact, could be a totally different way. It suggests that in order to time travel, you have to somehow, God, it's like we don't even have the language to be able to understand what they were doing.

There's a phrase, the past is a foreign country. Likewise. We need to learn the language of the doctors of that time. We need to kind of be a little bit less dismissive and learn a little bit more, you know, from them. I learned a bit of humility this way. But here's the reason why this is so confusing to me. So 1100 years is a crazy long time for humans

and for bacteria, that's like a exponentially crazy long time. So how is it that something that this man bald was doing to these bacteria then, like it's not even the same bacteria. How could that even work? That's an awesome question. So one thing we've got to think about is,

well, why did these medicines drop out of use? And maybe it's because when they were used, the bacteria evolved resistance. But now, a thousand years later, when these medicines have not been used, you would expect that resistance to be lost. This is something that Maren McKenna mentioned to Soren and I,

that sometimes when you take a drug out of circulation... Sometimes resistance will decline. That doesn't always work, but sometimes resistance does decline. So if we had been using this compound through the ensuing thousand years, then maybe it wouldn't work. So there's an interesting discovery there, like that what worked once and then was resisted, you give it a rest and it can work again,

and it will be resisted. And you put it to rest. And if you had enough different, you could go to different places in the different past, and to go to China, where they now got all these people studying Chinese cures and Arab cures, you could come up with a rich historical cocktail of armamentariums that will work. If you bring them in, take them out. Bring them in, take them out.

And the whole world, the whole world of the past then becomes the food of your future, sort of. So it's also, like now I have a suddenly an image that it's possible that... This is Soren Wheeler, by the way, in conversation with Mary and McKenna Latif. That a thousand years ago, these folks went through what we went through with penicillin,

in that this guy wrote something in the book and it's actually called the best medicine. He probably got on the cover of whatever their version of time was. He got their Nobel Prize. And everybody celebrated. And then years later, Stuy's were coming back and the garlic wine didn't work anymore and they stopped using it and it got put away. And then here we are and we discover it and it's been put away long enough that like then now I'm thinking about future, some future civilization digs up an old medical textbook that was in some dusty whatever and discovers penicillin and it works.

Did I lose you on that, Mary? No, no, I'm still with you. I'm just, I don't know. It just seemed like such a great hypothetical construction. I just didn't really know what I could add to it. Sorry. Sorry I took over. Hallelujah, hallelujah, hallelujah, hallelujah.

Thank you for listening. It's actually, it's been almost a full decade since we aired this episode. And since then, Christina and Freya have published several papers to show how this concoction works and why. Apparently there's not just one but multiple key ingredients at work in their ancient selves. They've also been collaborating with PhD students to create a recipe that can be turned into an actual medicine available to folks like you and me. But science is a slow process, and things like logistics and funding

just make it even slower. They are pretty hopeful that they will get something to us before the next 1,000 years pass by. Produce your lots of Nasser with help from Soren Wheeler and produced by Matthew Kilty. Special thanks to Sarah to Steve Diggle. And to Alexandra Ryder and Justin Park, who came down from Yale to be our old English readers.

To Gene Murrow from the Gotham Early Music scene. And to Marcia Young on the medieval harp. Collin Monroe of Tadcaster. And the rest of the Barony of Iron Bog. Not totally sure what that is, but I know they helped us out. And I guess we should help ourselves out. Yes, very quickly. Or through the window.

I'm Jad Abumrod. I'm Robert Krilwich. Thanks for listening. Hi, I'm Alana and I'm from Queens, New York. Radiolab was created by Jad Abumrod and is edited by Soren Wheeler. Lulu Miller and Latif Nasser are our co-hosts. Dylan Keefe is our director of sand design.

Our staff includes Simon Adler, Jeremy Bloom, Becca Bressler, Akati Foster-Kies, W. Harry Fortuna, David Gable, Maria Paz Gutierrez, Zindianna Simbundum, Matt Kielte, Annie McEwen, Alex Nisen, Sara Khari, Sarah Sandbach, Arianne Wack, Pat Walters, and Molly Webster. Our fact checkers are Diane Kelly, Emily Krieger, and Natalie Middleton. Hi, this is Ellie from Cleveland, Ohio. Leadership support for Radiolab Science Programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simon Foundation initiative, and the John Templeton Foundation.

Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.