Sawbones: A Marital Tour of Misguided Medicine - Sawbones: Vitamin K

Episode Date: April 7, 2026

No, not the musical artist who sang the graduation song (that's Vitamin C). Vitamin K has been in the news a little bit lately because it's often given as a shot to newborns. Dr. Sydnee talks about th...e history of its discovery, what it is for, why it's important, and why in the world it's called Vitamin K. Music: "Medicines" by The Taxpayers https://taxpayers.bandcamp.com/ Marsha P. Johnson Institute: https://marshap.org/

Transcript
Discussion (0)
Starting point is 00:00:00 Sawbones is a show about medical history, and nothing the hosts say should be taken as medical advice or opinion. It's for fun. Can't you just have fun for an hour and not try to diagnose your mystery boil? We think you've earned it. Just sit back, relax, and enjoy a moment of distraction from that weird growth. You're worth it. Welcome to Sawbones, a marital tour of Miss Guided Medicine. I'm your co-host, Justin McElroy.
Starting point is 00:01:11 And I'm Sydney McElroy. Here we are against it. That's true, Justin. I am panicking because I'm realizing I don't have a drink. And I am going to be stuck here. I didn't mean like that. Stuck here podcasting. And I could don't have a drink.
Starting point is 00:01:29 And I don't normally like it when I don't have a beverage. I mean, you know that you do not need, like you can go 30 minutes without consuming liquids and you'll be fine. Yeah. Like health-wise. Yeah, but what if my whistle gets a little? Well, you've talked about this country's obsession with water and hydration. It's some kind of refreshment. If I need a refreshment while I'm podcasting.
Starting point is 00:01:51 Maybe one of the kids will bring it. That would be the first time they've been helpful, except for the other time Charlie brought that drink down to me. Exactly. Exactly. I bet one of the kids would bring you a drink or maybe the cat. She's not going to bring you a drink. She's not going to bring you a drink.
Starting point is 00:02:05 No. Sid, what are we talking about this week? Well, Justin, what I want to talk about this week is vitamin K. It has been in the news a little bit lately. Well, are you aware of that? Is she the one that did the Friends song, as we go on, we remit. Is that her? Vitamin C, I believe. Vitamin C. Okay. No, then I do not know vitamin K. What, we've, we've been doing sawbones a long time, and I think that it's fair to say that we now, we can.
Starting point is 00:02:38 we can state that our approach to science communication in the medical community for many, many years, hundreds of years, from its beginning, perhaps, was not necessarily the best. Right. We, our model of medicine was what we used to call paternalistic, meaning that I, the doctor, tell you the patient what to do. You don't really need to ask questions. That's for me to understand. You just do this.
Starting point is 00:03:05 Take this pill, eat these foods, don't eat these foods. don't eat these foods, do these things. And crucially, it puts the control of your health in the hands of the physician. Yes. So rather than being someone who is advocating for your own health, it's the doctor's responsibility. Yes. It is our job to keep you healthy. And the only way that we fail is, well, I mean, really, we can't fail.
Starting point is 00:03:28 You can fail if you don't do what we say. And I guess if we tell you the wrong thing to do. But if we tell you the right thing to do and you don't do it, that's on you. not like we told you what you do. It's really the because I said so kind of approach to medicine. But why, Doc, because I said so. So that approach, I think, still permeates a lot of our medical conversations today. And there are a lot of reasons for that. Like we're pressured to do things faster. Efficiency leads to more profits in the healthcare industry in this country. And so the faster I can get you in and out of my office or in and out of my hospital, the more money I can make off of you.
Starting point is 00:04:04 and I don't mean that me, the doctor necessarily is driven by that, but certainly our bosses are. Sure. And so if I can just tell you, hey, your baby really needs to get this shot okay, because I said so. Okay, but why does my baby need a shot as soon as they're born? Well, do you want them to bleed to death? That's a no. No. But does that explain to you why you need to give your baby your brand new newborn,
Starting point is 00:04:30 precious little bundle of joy a shot? No, it doesn't. I would like to know why I need to give my special little guy a shot. And I think especially in light of the fact that not only has there always been sort of fears and misgivings about things we do to babies, you know, how, how the reason that there's so much fertile ground for vaccine hesitancy is because it's scary to give baby shots. Right. Like it just is. And so, of course, if there's an excuse, you can tell yourself not to do it. And then if you have the entire Department of Health and Human Services and the Secretary of HHS, as well as the new incoming surgeon general, all sort of adding to that and saying, yeah, maybe it isn't a good idea.
Starting point is 00:05:13 Maybe you should. Maybe it should be shared decision making. Maybe not everybody would get the vitamin K shot. It's really easy then to turn around and say, like, well, maybe I'll put it off. Maybe I'll think about it. Because you don't have the base of understanding in the populace as to why we're doing it now. Yes. Because on a very base level, wouldn't you wonder, well, why does every baby need a, like, did babies need vitamins before?
Starting point is 00:05:37 Right. So what is it that's happening that we need to give the baby something special for? Okay. So let's talk about the history of this. Who came up with, how did we figure this out? Why is it necessary? And why does it have to be a shot? I think it's always a fair question because I really believe that if most vaccines and measures like the vitamin K shot were pills, I don't think.
Starting point is 00:05:58 we would have nearly as much resistance. Yeah. So back in the 1800s, our understanding of newborn physiology was still developing. Right. Are they like regular humans but small? No. That's basically it. No, they're not.
Starting point is 00:06:11 I mean, that's really important to understand about kids. No, that was our understanding. Yes. Small adults. The initial thought was that babies are just small adults, and so everything works the same. It's just like tiny. Yeah. Right.
Starting point is 00:06:23 And what we were... Some guys like, I think adults are actually all things. three kids stacked on the top of each other in a trench coat. And the other scientists were like, well, that's pretty easy to disprove. And they were like, you're right. How did you get in here? I mean, you've seen, you've seen pictures of depictions of, like, the baby in utero from those early, early anatomical drawings. And sometimes it is just like a little man, just like standing there. Just like a little guy, so, you know. I love that. I love that little beard.
Starting point is 00:06:52 A little flannel shirt. It's like he's just standing in there all dressed and ready. Ready for work. There's a time for me to work the fields. Papa. Ready for the office, mother. So we were still figuring out that some of the processes, some of the things that happen in adult human bodies or even in older children may not be fully functioning. They're kind of like ramping up when you're first born.
Starting point is 00:07:15 You're done, but not completely done. Okay, yeah. Right? Sure, like you got the fontainell at the beginning, still closing over. It's like that on a larger scale. Well, you know how you take like cookies out of the oven while they're still just a little soft because they're going to continue, you know? Keep baking on the table. They're going to keep baking a little bit longer.
Starting point is 00:07:37 It's like that. We're going to keep baking a little bit longer. And that's fine. But that means that some things aren't quite working yet. And this is true for all babies, by the way. This isn't necessarily like if you were born early or with some of their kind of issue. This is everybody. Not everything's working.
Starting point is 00:07:52 One issue that particularly concerned medical professionals was bleeding. Now, we've done a whole show on hemophilia, and there was a pretty decent understanding of hemophilia at this point in history, largely because of the royal family, right? She was thoroughly studied. Yes, we had very important, rich, famous people who had hemophilia and who we could easily branch out their family tree because all of it had to be a matter of record. And so we knew. It's like that in our gout research. It's like so good at this. I was like, listen, every time I'm going to.
Starting point is 00:08:25 I eat 12 hams, my feet fall off. What's happening? It's like, okay. So there were, it's true. That's probably why hemophilia. I mean, there were so many charts to understand hemophilia at that point. But what we knew is that some babies were born with bleeding issues. And at the time, it would be easy to toss them in the same bucket.
Starting point is 00:08:43 They would call like hemophilia's bleeders, easy bleaters. I don't think. No, not literal. That's one of the worst things about the time period. We didn't realize that it would be a problem to store them all in the same bucket. It's all the blood. Wonder Bay Bucket. Justin.
Starting point is 00:08:57 But what we started to realize, this is in 1894, that there were some babies who were born and had bleeding issues, but then maybe didn't continue to have bleeding issues for the rest of their life. And so they began to sort of separate out this kind of segment of like, okay, those are the hemophilia patients. They're going to have bleeding issues forever. But what's going on with these babies? And we didn't know yet.
Starting point is 00:09:24 But the first description of something that we eventually would figure out how to do with vitamin K is accredited to a Boston physician, Charles Townsend. In 1894, he described he put together an entire paper with 50 cases of bleeding tendency in neonates. And he didn't know why. I mean, this is kind of, this is the process of figuring out like a new disease process or, you know, pathogen or whatever. You need a bunch of, you kind of come from the top and then get smaller. We're looking at the actual babies, what is happening, what age does it start? Let's get some demographics. Let's get some information about the birth.
Starting point is 00:10:01 You know what I mean? Like put together a portrait of what is this syndrome, what is happening. And then you can start kind of zooming in on what might be causing it. So hemorrhagic disease of the newborn is what he called it. And he basically said it's not the same as hemophilia. So I understand bleeding is bleeding, but this is something different. It usually happens on day two or three. so it's much earlier.
Starting point is 00:10:26 Okay. It's cuter. Why would it be cuter? I don't know. That's one of the weirdest things about hemorrhagic disease of the newborn. It's somehow cuter.
Starting point is 00:10:33 It's hard for me to explain, but it is one of the main signs how you can tell the difference is that it's kind of an adorable hemorrhagic disease. I would, it is not. Just because it's babies, you know. That makes it worse.
Starting point is 00:10:47 Good point. Yeah. That's true. I mean, to my, like, I think it's worse. I think every child's beautiful, Sydney. I'm sorry. Sorry, I don't know what to tell you.
Starting point is 00:10:57 But I mean, because I think they're beautiful, I don't want them to bleed. No, that's true. That's true. You didn't listen to a lot of like nine-inch nails in high school because that's really, you missed the message. So he began to talk about these earlier presentations. They didn't have a family history. So like at this point, we kind of knew that hemophilia, we could chart its progress. So like all of a sudden you've got somebody who's having a bleeding issue and nobody in their family did.
Starting point is 00:11:20 So this is different. And then it tended to have a self-limity. limiting time course. So there was one case in which a nine-day old baby had a hemorrhage and then went on to not have any other issues. Although initially, I mean, it was very, there was one case where there was a nine-day-old infant. It had a hemorrhage. As you can imagine, this would be very devastating to the parents because while they understood what hemophilia was better than some other things, they still didn't have good treatments for it, right? So you think, oh, no, my baby's been diagnosed with this terrible thing. This is lifelong. And then there wasn't.
Starting point is 00:11:53 the baby didn't continue to have problems. They grew out of it? Well, this is a time-limited issue, as we're going to see, whereas hemophilia is with you forever. Vitamin K-related bleeding events are singular. We'll get into it. We'll get into it. And he also, by the way, made a link between the fact that this particular mother was unable to breastfeed, and this infant was being supplemented with formula. Did the formulas have like deficiencies at that time or did we know about that kind of stuff?
Starting point is 00:12:28 There's actually a link between a little more, you are more likely to bleed if you do breastfeed. So the thought was that the reason the kid recovered and didn't have more issues is because he was formula fed. Huh. Anyway, this was probably one of those things where he noted this, this like connection and this would have thrown us off completely and we would have gotten it wrong. He is kind of noticing something that's true and we'll play out. But it's interesting because there's something there. He's not quite hitting it on the head. But there's something there, okay?
Starting point is 00:13:01 So we didn't know what was happening. We had to unlock the mystery. Why is there bleeding happening in these newborn babies? What is the difference? And why is it something that seems, if they can survive, that early neonatal period, they go on to not have problems as an adult? I think if you give me a couple of hints, I will be able to get it. But right now, I am not sure.
Starting point is 00:13:23 Justin, I'm going to be honest with you. This starts with an understanding of the coagulation pathway or coagulation cascade. Okay. So you've stumbled into one of my areas of expertise. Oh, is it? Oh, yes. Mm, really? No, sorry.
Starting point is 00:13:38 I'm going to tell you that it is not an area of my expertise. I would say that outside of hematologists, we all, I mean, I know what it looks like. And I kind of, I mean, I got, I started it. But if I was going to have to sit down and do some complex, like if I was going to teach med students about the coagulation cascade, I would have to study it again myself and have a diagram next to me. Because it's incredibly complex. There's lots of factors. It doesn't just dry. A lot of people think that it's just drying. There are multiple steps in an incredibly complex pathway. There are different ways that it can be initiated. There are all kinds of ways that it can be interfered with, disease processes,
Starting point is 00:14:19 toxins, medications, injuries, substances that can stop it from working and then all different ways to fix that, depending on what broke the cascade to begin with. It really is a really complex system of dominoes that all have to fall in the right order in order for you to clot. It's easy for that system to get interrupted. Yes, yes. And if any of that goes wrong, then you can have bleeding or clotting depending on where something went wrong. So it would be presenting in the same way, but there's enough different ways that it could happen that it's not necessarily the most like informative symptom. Yes. Because I mean, even as we talked about with hemophilia, there are different kinds of hemophilia depending on which clotting factor you don't have enough of. And on the surface, you're bleeding because I can't tell by your bleeding which of these two clotting factors you weren't making, right?
Starting point is 00:15:13 You needed both. You didn't have one of them. Yeah. So, I mean, it takes a lot of modern understanding and technology to be able to unwind this kind of stuff. So in the beginning of the 1900s, we barely understood anything. We use the classical model of coagulation at that point. From 1905, it was devised by Paul Morowitz, and it was basically two steps, which if you look at a modern clotting cascade, that's, I mean, there's many, many, many more. So something called pro thrombin has to become thrombin, and then that helps fibrinogen become clot. Doesn't matter.
Starting point is 00:15:46 The point is this was our understanding. Okay. But that was like basic. That was very basic. Okay, got it. I'm going to, listen. I'm going to show you a picture. There's an audio kind of deal.
Starting point is 00:15:57 Yeah, I know. But I'm just going to show you a picture because I feel like then you'll understand what I'm talking about. Ah, oh, man. If I show you a picture. None of these are the pictures that I want to show you. Is this going to need a picture of scabs? No, no, no, no. Clotting Cascade.
Starting point is 00:16:19 This is the clotting Cascade. clouding cascade diagram. Okay. Here, that's probably a pretty good one. These are all the different steps involved. It looks like a... You've got so many different factors. Ones and twos and threes and all the way up to 12s there.
Starting point is 00:16:31 It looks like a really robust flow chart. Yes, and it comes in different directions because it's... Did the bleeding start from inside or outside? And then there's a common pathway and look at all these different places where things can go wrong. Every time you see something that has to become something else, that's a place where stuff can go wrong. Yeah. A lot of different places. Right. We didn't understand that yet.
Starting point is 00:16:52 This wasn't wrong. It just wasn't complete. And then this is where we get Danish biochemist, Dr. Carl, Peter, Henrik, Dam. Now, he was not studying clotting. Whoa. He just kind of noticed? He was studying cholesterol. Oh.
Starting point is 00:17:09 He was trying to figure out if baby chicks can synthesize their own cholesterol. We knew that dogs and mice and rats could, but we didn't know if baby chicks could. So he was trying to figure out if they could. Now, I don't know. We're just trying to understand everything. Okay, Justin, sometimes. But look, this is why we do science like this. Right.
Starting point is 00:17:29 Because he's trying to understand if baby chicks synthesize cholesterol. Yeah. So he's feeding newborn chicks. And he's like, I don't know, I just got to feel like something good. Trust me. Hang in there. Something's coming. Something's coming.
Starting point is 00:17:40 I got a good one cook. So he's got all these little baby chicks and he's feeding them diets from which all the sterols, all the cholesterols have been removed to see what would happen. We knew about some vitamins at this point, by the way. So he's given him A and D because he knew that, like, we've got to make sure A&D have to be in there. So we're giving them that, and we're keeping out the cholesterol. And what we found is that they do synthesize their own cholesterol. Okay.
Starting point is 00:18:01 Nice. Research ended. Eat them. Now we know that. But then we noticed a strange side effect. What? The baby chicks that were on this sterile-free diet began to develop bleeding issues. Hmm. Like all of them? Not all of them, but quite a few did.
Starting point is 00:18:15 They would have bruising and bleeding under the skin. When they would draw their blood for the testing, it wouldn't clot. It would just keep bleeding. So what is going on? This doesn't have, he knew enough about cholesterol. I don't know. That's isn't a cholesterol problem. So what's going on?
Starting point is 00:18:30 I'll tell you what's going on. Wholesalers getting pretty mad about all this inferior product. They're getting all this bruised chicken. They're receiving in the box. They want to know what's going on. Yeah, why are all these chicks bruised? These chicks are all bruised. I paid for primo chicks.
Starting point is 00:18:43 All right, so think on Justin What might be missing from these baby chick diets While we go to the billing department Let's go The medicines The medicines that ask you lit macabre for the mouth Is it vitamin K? Well, spoiler
Starting point is 00:19:03 No, I mean you said at the beginning It's about vitamin K I mean, I don't think If I haven't picked it up by this point It would be pretty bad if it was like the answer What's compression sucks So as as And it's interesting
Starting point is 00:19:16 Because if you read like Henrik Dam, as he is studying this, he's also like doing other things. Like I was reading like his description of how he figured all this out, like hit the paper he published. And he notes that like he was busy with some other stuff for a few years. So there were like some other researchers who were trying to figure this out too. And he also kind of throws shade at him because the thought was, okay, so it can't be cholesterol. We know that vitamin A and D are in there.
Starting point is 00:19:42 They tried different things, adding different things to the diet to see if it fixed it. and they noticed cabbage fixed it. Like if you fed the chick's cabbage, they didn't have bleeding. And so the initial assumption was vitamin C because that's in cabbage. And if you think about our understanding of like scurvy,
Starting point is 00:19:57 which we already knew about at the time, you might think like, oh, well, like your gums bleed, so that makes sense. Maybe it's a vitamin C deficiency thing. However, as Henrik Dan pointed out in his kind of, he had like a kind of like shady statement in his.
Starting point is 00:20:09 He was like, but like we knew that wasn't right because they already had research that said newborn chicks don't really need that much vitamin C. and then he gave him lemon juice. And he was like, see, didn't fix it. So eventually he got back around. It's really weird because he found this initial thing
Starting point is 00:20:27 and a bunch of people were like trying to figure out and he's like, I'm busy over here for like three years doing some other stuff but I'll get back to this and I'm going to crack it. I love that he's like, I don't know, I'm doing a really important stuff with chicks right now and how I had to finish my important chick work and then I'll get back to the humans.
Starting point is 00:20:44 He did. He had to finish his. important chick cholesterol work. And then he finally got back. And what helped is when he got like re-interested, I guess, in this problem, we had an easy like vitamin C supplement. And he was like, so I was going to blow this one out of the water because I just started injecting these chicks with vitamin C and they were still bleeding. And I was like, told you so. So they started just basically trying to isolate what substances or what foods do we feed the chicks and it gets better. And they found that like leafy greens help fish not so much hog liver super helps and it's interesting
Starting point is 00:21:22 because they're actually like also they seem weirded out by that one we gave them hog liver they're like uh okay it seems like a lot or chicks but as they're doing it they don't they don't know what the substance is they just know some foods have it and some don't and they're even like talking about the amounts of whatever this new mystery substance is in the in the foods by how much you have to give the chicks for the bleeding to stop. Crazy. Like that was the like unit of measurement for this new substance in the, in the various foods. Hmm.
Starting point is 00:21:54 Isn't that cool? That's really wild. Yeah. Anyway, by 1935, they had isolated a new compound. And at the time, according to his paper, what he said is we called it vitamin K because it was the first one in the alphabet that had not been used for another vitamin at this point. So we did. So, oh, wow.
Starting point is 00:22:14 So they're like discovering vitamin K this way. This is how they discovered vitamin K. It's like the deficiency of it is what makes you realize. That's like realizing you're lonely when you're a teenager. All of a sudden, it's like, hey, wait a minute, I'm lonely. What's happening? So they said vitamin K, and then they also thought it was very convenient. Now, I mean, according to Henrik Dam, he said, and I mean, in his paper,
Starting point is 00:22:40 it was the first letter that hadn't been used yet. Now, that led me to wonder, and I haven't researched this, like, vitamin G and H. I mean, I'm assuming there must be right. Yeah. He's probably not lying about vitamins. I mean, where are these vitamins? What's the, what ones do you know? Do you know any G through I's?
Starting point is 00:22:58 No. I know A, B, C, D, E, and K. There are lots of Bs. Now, I don't know if all the Bs initially got their own letters before they got lumped in. I think that's when everybody got fed up with the whole thing. It's when we started numbering the bees. I think that's when everybody was like, never mind, I quit. I'm not doing it with you guys.
Starting point is 00:23:18 This could maybe be another episode, too. I'm sure that this is a truth that I just don't know yet, that this is a historical. The hidden, the banned vitamins. The banned vitamins. Or they weren't vitamins. Like, we might have named other things vitamins. And then it was like, oops, sorry. Turns out one of them was just pocket lint.
Starting point is 00:23:32 Oh, geez. That was something else. Oh, geez. Doug had a junior mint fell on this dang slide. It's nothing. That's not a vitamin. He also, he also, noted that a lot of people liked it because
Starting point is 00:23:44 the Scandinavian and German spellings of coagulation are K, coagulation, they start with a K and so since it helped your blood clot or coagulate, vitamin K. It also is easy because you can take the kid up the aisle, but you can't take the aisle out the VK.
Starting point is 00:24:00 So it's a good reminder if you're a fan of the dissidents' franchise, it's easy to keep up with this. The VK. Yeah. So he won a Nobel Prize for this. And then he, And a bunch of researchers were like, he was kind of done. He was like, good, there you go.
Starting point is 00:24:15 Vitamin K. Have fun. Have fun with that. You should stop there because what if you do some bad science? If we were like, actually, this guy's not really that's more. I think he, I mean, he definitely did other science. But I think that his most notable achievement, I would bet, is that he discovered vitamin K. Pretty good.
Starting point is 00:24:29 Which was super important because the question then became, I mean, you can see where researchers put this together pretty quickly. So if newborn chicks don't have vitamin K, they bleed. Well, all these newborn babies who are having these mysterious bleeding episodes, do they need vitamin K? I don't know. We just didn't invent vitamin K. So the first, well, we didn't invent it. We just sort of found it. Well, and then we came up with the name for it? Yeah. Okay.
Starting point is 00:24:57 That's kind of what we do. So we've admitted it. We find things that already exists, and then we name them and say. All right, we named it. Well, that was our charge from the Lord, Sidney. He told us to name everything. We're just doing our job. I thought only Adam was supposed to do that.
Starting point is 00:25:12 Yeah, but he didn't know about everything. Like, he didn't know about giraffes probably were like ATVs. Like, he couldn't have come with that. Well, no, he definitely couldn't have named ATVs. So in 1944, Jorge Lehman, a Swedish researcher, did a study where 13,000 infants were given 0.5 milligrams of vitamin K. This was either a pill or an injection at this point. We didn't know which one, we didn't know what would work on the first day of life. and the published research showed that infants who got vitamin K had a five-fold reduction in the risk of bleeding to death during the first week of life.
Starting point is 00:25:48 From that study, they estimated that for every 100,000 full-term infants, vitamin K would save the lives of 160 infants per year. This was in 1944. Please remember that number. All right. And I think, I think, like, with a lot of things that we talk about in the under two age group, there are so many medical advances that specifically why people live longer is because so many more babies make it out of their first year or two of life. Right. And the reason... It's a math thing. It's a math thing. And the reason, one, we're very vulnerable then. Two, we make these medical advancements and we take this so seriously because if you think about, I think, the moral weight of the loss of those years weighs heavier on our side.
Starting point is 00:26:37 souls. And so, you know what I mean? So one is too many. So 160 out of 100,000, maybe that math doesn't sound impressive to you, but one is too many. So anyway, they began to, of course, isolate a number of different foods where vitamin K could be found and how much. And like I said, the original, all of our international units, you know, vitamins are measured in international units often. And it's like, what is that? What is the, you know, it's not a gram. It's not a, you know, I mean, what is an international unit. It's just like a standardized measurement system that we've come up with. And it was based on how much was needed to prevent bleeding in baby chicks.
Starting point is 00:27:17 Yeah. We also discovered that vitamin K is made by our gut bacteria once we have established that. And so that was part of why we began to figure out, as we studied this further, why is this specifically an issue in babies? Because they haven't had time to develop the gut bacteria. Yes. So one, when we are first born, our microbiome, like our natural gut flora, the stuff, though, good bacteria that you want living in your gut hasn't formed yet. And it takes a while, so it's not making vitamin K. The other thing we understand is that, and through the 70s, we really began to understand clotting and clotting factors.
Starting point is 00:27:55 And our livers make all of these different, and that's what we call them clotting factors and they're numbered, that are involved in the coagulation cascade and the pathway that gets us to, forming a clot. Vitamin K helps our livers make multiple clotting factors and proteins that we use for clotting. Okay. So since you don't have all the clotting factors you need when you're born, our livers are still ramping up, right? Right. That's why you sometimes get like jaundice.
Starting point is 00:28:25 You know how some babies get a little jaundice when they're first born? Yeah. Their livers are still kind of like coming online. Their liver are still booting up. Okay. So you're not making enough clotting factors. You don't have much vitamin K. Vitamin K does not cross the placenta readily.
Starting point is 00:28:40 So no matter how much you eat. You know the parents like taking a bunch of vitamin K in. You can, yeah, you can smash leafy greens all day long, but it's not going to get from the person who's pregnant to the baby. They don't have the gut floor. They don't have the clotting factors. So they are at higher risk for bleeding. We also found breast milk has less vitamin K than formula.
Starting point is 00:29:01 So breastfed infants specifically were at higher risk than formula-fed infants. Feeding formula wasn't enough to control for that risk still, but you are more likely to see these bleeding events in breastfed babies over formula-fed babies. So the logical conclusion from all of this research was, well, hey, vitamin K is, I mean, pretty much risk-free. Why don't we just give it to babies at birth? Yeah. Seems smart to me. Yes. and so that if we give them on the first,
Starting point is 00:29:34 immediately within 24 hours of birth, if we give them some vitamin K, we can prevent all the different forms of vitamin K deficient bleeding, VKDB, vitamin K deficient bleeding in newborns. That's what we would call it now. We don't call it the hemorrhagic disease of the newborn, any of that.
Starting point is 00:29:49 We know what it is. They don't have vitamin K. Early occurs in 1 in 60 to 1 in 250 newborns. Late is more rare occurring in 1 in 14,000 to 1 in 20. 25,000 infants early is within the first 24 hours. And there are some specific risks, like maybe some medications that the pregnant person could have been taking or certain conditions that may have been happening during the pregnancy. And then it presents in one to seven days. There's bruising, bleeding from the umbilical cord, maybe the circumcision's bleeding.
Starting point is 00:30:18 And the late can occur in two to 12 weeks. It's rare. And that can present some more severe bleeding episodes. Infants who do not receive a vitamin K shot at birth are 81 times more likely. to develop vitamin K-deficient bleeding. 81 times. Yes. Wow.
Starting point is 00:30:37 And it absolutely can be catastrophic. So vitamin K-deficient bleeding could manifest as, like we talked about, you're bleeding from the site of where they cut the umbilical cord or from the circumcision more than you would expect, and maybe it takes a little bit longer to achieve hemostasis, right? And so, scary, but not devastating. bleeding can occur in the brain and that can lead to severe disability and death
Starting point is 00:31:06 and so it is absolutely something that can be fair can and has been fatal to newborns there is no there have been some concerns through the years about specific side effects of the vitamin K shot okay well but somebody once
Starting point is 00:31:21 tried to link it to a certain kind of leukemia there's absolutely no correlation between that anywhere any research that's been done, there has been one case of an allergic reaction to a vitamin K shot that we have documented, one case. And there is a preservative free formulation. So if you want one without preservatives, which have been found to be safe, but you still don't like them. They have that. They recommend that, you know, if it is a shot, probably the newborn will cry. Yeah.
Starting point is 00:31:56 So use measures to ease pain, cuddling, and comfort. You can have some redness or irritation at the injection site. And again, eating more vitamin K during pregnancy will not alleviate this. We've done studies that back it up. While we find more vitamin K in the pregnant person, it isn't getting effectively to the baby. They also did a study to look at oral route of administration. So like since so many people don't like shots, what if we did instead of a single shot given at birth, could we do a three-dose, two-millogram oral regimen?
Starting point is 00:32:30 And what they found is that it does lower the chance. It does still work. But the problem is, one, it still is not quite as effective as the injection. And two, it's over the course of three weeks. Oh, that's tough to keep track of. Well, you give them that first dose when they're in the hospital, but then what you're trusting is that they're going to remember those next two doses outside the hospital. And it may or may not happen.
Starting point is 00:32:53 So the safer route is a single vitamin K. injection given at birth will dramatically reduce the risk that your baby has a catastrophic bleeding event and the risk of the injection, I mean, you can't ever, to be a good scientist, I can never sit here and say the risk is absolutely zero, but the risk is as close to zero as one would comfortably feel sane, knowing the limitations of human understanding. Does that make sense? Yes. So I hope that untangling all this, because I do think especially newborns, I had the same thought when it was recommended to me, because I was breastfeeding, that I should supplement with vitamin D. The first time that I heard that, I was like, surely my body makes,
Starting point is 00:33:37 surely, right? Like, nature made me to make this for this little person. And like, isn't that how, shouldn't that be enough? No, no, it's not. And we have science to tell us it's enough. It's not enough. And we also had a lot of kids with rickets for a lot of years and with vitamin D deficiency for a lot of years. And so, like, we know that just because something seems like, well, I mean, shouldn't that be enough? Shouldn't that make sense? No, sometimes it's not. And science shows us that. We also have lots of medications that right size the chemical comings and goings of our bodies.
Starting point is 00:34:09 I don't think that that's such a surprise that we could find something that would benefit us early in our life if there's things that later on in life we would benefit from taking. It really is. I would urge you because, I mean, specifically, I have heard the new surgeon general calling the vitamin K shot and its necessity into question. And as a person who never practiced medicine, I'm not sure why she feels that she's qualified to call it into question. And the devastation of something so small being parents foregoing it out of fear that has been created by public health officials. and then something happening to your newborn. I mean, it's just, it's horrific. So this is how we untangle it, though. This is how we got here. This is why we know it works. We don't just say, do what I say, because you don't want your baby to bleed to death.
Starting point is 00:35:03 Nobody wants their baby to bleed to death. Agreed. Everybody's trying to do the right thing for their baby. Yes. So let's help them make that decision. But now you know about vitamin K. Go tell some folks about vitamin K this week. That's your homework.
Starting point is 00:35:18 I've never given you homework. Why would I start now? Thanks for listening to our podcast. And thanks to the taxpayers for the use of their song medicines is the intro and outro of our program. We really, really appreciate it. If you want to send us a message, you can email Sawbones at Maximumfund. Or you can send your weird medical questions here, what have you. That's going to do it for us for this week.
Starting point is 00:35:39 Until next time, my name is Justin McElroy. I'm Sidney McElroy. And as always, don't drill a hole in your head. Maximum Fun. A Worker Own Network of Artist-owned shows. supported directly by you.

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