Sawbones: A Marital Tour of Misguided Medicine - Sawbones: Walking Pneumonia

Episode Date: December 10, 2024

It’s nearly winter, which means the return of mycoplasma or “Walking Pneumonia” on this hemisphere. This week Dr. Sydnee and Justin talk about how this infection was discovered, the questionable... way it was researched and how it differs from “typical” pneumonia.Music: "Medicines" by The Taxpayers https://taxpayers.bandcamp.com/Harmony House: https://harmonyhousewv.com/

Transcript
Discussion (0)
Starting point is 00:00:00 Sawbones is a show about medical history, and nothing the hosts say should be taken as medical advice or opinion. It's for fun. Can't you just have fun for an hour and not try to diagnose your mystery boil? We think you've earned it. Just sit back, relax, and enjoy a moment of distraction from that weird growth. You're worth it. Alright, this one is about some books.
Starting point is 00:00:29 One, two, one, of misguided medicine. I'm your co-host, Justin McElroy. And I'm Sydney McElroy. Happy holidays. That's a weird. I hadn't wished you happy holidays. That's a weird energy. I realized I hadn't wished you happy holidays yet.
Starting point is 00:01:16 Happy holidays, Sid. Happy holidays, Justin. Thank you. Honestly, I hadn't come up with an introduction, and then I looked at the name of the document you shared with me, and I don't know what I have. You don't know what it means. I got nothing. You don't know what it means.
Starting point is 00:01:31 I got nothing. That's fair, that's fair. I got nothing, I got nothing, so I said happy holidays and just hope that you would tie it together, because I got nothing. I don't know what this means. We're a little, this is timely, it's just a little behind. There's been an, and I try to keep up with
Starting point is 00:01:44 if there's like a little behind. There's been an, I try to keep up with if there's like a new outbreak, an infection, something rising, something whatever that I feel like would, oh wait, this is a good opportunity to talk about history and educate on a current thing. And we're little, this is, so have you heard about the increase in cases of pneumonia in children? No, have you?
Starting point is 00:02:04 Well, obviously I'm doing a podcast about it. Yes, that is a very fair response. Also, I'm a physician, and also we're parents. I'm just trying to keep the conversation going. Sydney, it's a conversational style, okay? It's called asking questions. No, I don't know what that is. Have you heard of that increase?
Starting point is 00:02:24 I will say yes, and I will say, I do think there is a little. Have you heard of that increase? I will say yes. And I will say, I do think there is a little bit of benefit. It's just another conversation, Sydney. It's just, I'm just keeping the conversation. This may be a lesson that COVID taught me. We tried to jump out, I think pretty early on the, when, before COVID was COVID and it was like, there's a coronavirus in China
Starting point is 00:02:44 and that was all anybody was saying. We tried to jump out pretty early on that and we were not worried and we were wrong. We weren't worried and we were being too optimistic and we were wrong about that. And we were wrong. And so maybe waiting a little bit, gathering some more information is a good idea.
Starting point is 00:02:58 For instance, I am not talking about the new mystery illness in the Democratic Republic of Congo because I don't know what it is. No one seems to know what it is yet. There's really not much to say about it yet. I don't feel like me weighing in with guesses would be- You just wanted to raise the specter of worrying about it without any sort of context.
Starting point is 00:03:17 Well, I imagine many of our listeners are paying attention to that as well. And right now we don't know anything. And so I don't think me like theorizing on that would be helpful but talking about pneumonia. I've never heard anything about it, can you know that? How have you not heard about it?
Starting point is 00:03:31 Have I heard about? Sydney, I don't really hear about things. Like everybody in my algorithm is talking about it. Yeah, okay, mine's mainly Arby's. So, okay, I don't hear about these things but now I know, I just know that there's a mystery illness and my wife's not gonna tell you even more about it. So there is a lot of that concern
Starting point is 00:03:49 over this mystery illness. And all I'm saying is, I think at some point when we know more about it, it would be helpful to talk about that. And so this is the lesson I've learned. I'm learning from my past mistakes and I am growing as a person. I can talk about mycoplasma pneumonia
Starting point is 00:04:05 and how it's on the rise, or has been on the rise for the last year, because I think we know more about it, we understand, and I can say something helpful and not just cultivate fear around an unknown. So if you have been paying attention for any of these reasons, or perhaps if you've been sick or somebody you know has been sick, which is quite possible because it is pretty widespread.
Starting point is 00:04:29 Would you say it is fair, a fair assumption for me, if I see a healthcare story, to not click on it with the assumption that my wife will know what is happening? Do you think that's a fair assumption? I probably do pay a little less attention to medical stuff than your average person, because I assume that my cidgorhythm will bring it to my attention if I need. So you know that.
Starting point is 00:04:54 Well, and I guess that is bearing out right now. Yes, that's true. So Justin, you've probably heard of walking pneumonia. And the buggy flu. Most people have heard the term, the colloquial term, walking pneumonia. I've heard that colloquial. Do you know why, like what is that? I would assume it's because you're like sick,
Starting point is 00:05:13 but still good enough to walk, like you have pneumonia, but you still feel okay enough to go to your job. That is, that's kind of, yes, that is where the term comes from. Now this is obviously not true for everyone who contracts this illness. There are some people who get quite sick, but yes.
Starting point is 00:05:26 A lot of us- And there may be people who were not walking before. So you wouldn't assume that that would be affected by the pneumonia. No, not in any way. So the idea is that for a lot of people who contract this, it will either be a bronchitis, an upper respiratory infection,
Starting point is 00:05:39 or a pneumonia that isn't as severe as other pneumonias. In the medical world, we often call it atypical pneumonia. And we'll get into the history of that. Atypical being one word. Yes. Yes. Atypical, as opposed to typical. You're right. Yes. Yes.
Starting point is 00:05:56 Okay. There is an increase this year. There is nothing to be alarmed about. This isn't a new illness, it's a known illness. And we know how to treat it, and we know how to prevent it, and we know how to manage it. And we kind of know why there's an increase, and we also kind of saw that coming.
Starting point is 00:06:18 So I feel like this is all comforting, right? This is all comforting information when we know things. Okay, so let's talk about walking pneumonia first. And to understand why it's a little different than other, why do we have a whole other name for this pneumonia? Why is it different? Why do we care? There's a couple reasons.
Starting point is 00:06:34 And I think that it starts off with the difference between a virus and a bacteria. Okay. Do you know? Allow me to. To guess? Yes. No, not guess. Can I? Yes, no, not guess.
Starting point is 00:06:45 Can I, wow, that was so mean. Bacteria is a very small microscopic living organism. Okay. A virus is also very small. These two things, you can't even believe it. Virus is much smaller than bacteria, though. Yes, generally, yes. And virus is not dead and not alive.
Starting point is 00:07:04 Like Nosferatu, it wanders the earth, hovering between twilight and dawn. Not quite alive, not quite dead. The virus is a terrifying predator. This is true. I will give you that. I think that was the thing that drew me to viruses in the beginning, because before I became a family physician,
Starting point is 00:07:26 I wanted to study infectious diseases. And then before I wanted to go to medical school, I just wanted to do it in a lab and not have to deal with humans, just microscopes. Got it. And I think what drew me to it is that viruses exist in this sort of living and non-living space. And why is it important for us to know,
Starting point is 00:07:45 well, both can cause a pneumonia, we treat them differently. Right. And exactly like you said, Justin, bacteria are free-living organisms, they can live outside of us. Viruses need us or some host in which to exist. They cannot just exist.
Starting point is 00:07:59 If you spill a virus on a surface, which I know is a weird visual because they're very tiny, you wouldn't see it, but there's a virus on a surface, which I know is a weird visual, because they're very tiny, you wouldn't see it, but there's a virus on a surface, it's not gonna exist very long. It can last there for a determined period of time before it's gone. It cannot reproduce or thrive in the way the bacteria can.
Starting point is 00:08:16 If you get, nevermind, I was gonna sound really stupid. Could you get enough virus together that you could see it? So you can, not without some sort of instrument, not with the naked eye. Okay, got it. But they do, they can form- But we couldn't get enough viral particles together that we can see them?
Starting point is 00:08:34 I mean, they're so small. Yeah, but I mean a lot. I mean, I did not look at how many viral particles would you have to put together before you could see them with the naked eye. I don't think it's, they can form sort of crystal-like structures when you just sort of like stick them all together, which is kind of like some of them.
Starting point is 00:08:52 They're all different and there's, we're finding new ones all the time, by the way. We are great. Because like, for a long time, we couldn't tell all this stuff, all this thing that I'm telling you, like bacteria is a living, it's a single cell organism, and viruses are like these collections of genetic material inside proteins and they're kind of alive and kind of not.
Starting point is 00:09:12 We didn't know all that. We needed a better way to visualize them than we initially had because our original microscopes are just light microscopes. We're shining light on it, we're magnifying it, we're looking very closely. That's it. And you can't see a virus that way. Right. We didn't know all that yet.
Starting point is 00:09:28 We have better microscopes now, we can figure that out. But what is cool, I think, is that if you look at the history of microbiology, and especially when you get into the study of things that are infectious, things that can make us sick, the pathogens, because there's lots of stuff out there that's small that doesn't make you sick. Yeah.
Starting point is 00:09:46 But when it gets to the things that affect humans, we knew that things existed and we characterized them and we called them names before we could ever see them. Hmm, like the Roman gods. Why is that? What of all analogies? I just, I just see that it seems that, you know, we're looking for ways to explain what's happening in the world around us.
Starting point is 00:10:18 And you know, it's similar thing. It's a human impulse to want to try to understand things that we don't, right? So we create narratives. This narrative happened to be weirdly close to the truth, I guess, right? No, okay. See, I think these are two very different, but I mean, I think important and valuable human impulses.
Starting point is 00:10:39 One, to create a narrative to explain a phenomenon, and two, to scientifically study, to experiment and seek a truth. I think those are both valuable. Me too. And they both have their place. One of them in medical science and the other one in lots of media and other things we enjoy, right? Sure.
Starting point is 00:11:02 So once we kind of understood, because for a long time when we talked about this on the show, we didn't know why disease happened. So there were the humoral theories, there were miasmas, there's lots of- Big clouds of disease, free roaming clouds of disease. Demons, punishment by Roman gods, perhaps. The poor, just the poor writ large.
Starting point is 00:11:21 Just being poor, being near the poor. Drinking the same water as the poor, actually. Any of these things, yeah. Being a woman, you know. So once we knew that germ theory of disease was established. I was nodding thoroughly. I didn't say yes, yes out loud, but I was nodding folks at home
Starting point is 00:11:39 and drinking from my iced coffee, but I absolutely agree with my wife's sentiment. And then we established Koch's postulates, meaning like you can take the way we know that an agent, first of all, we know that things cause disease, they're contagious things, bacteria, viruses, fungus, parasites, whatever, that cause disease. And in order to figure out is the constellation of symptoms,
Starting point is 00:12:02 the thing that's wrong with you is it because of this tiny thing, we have to find it in you, take it out of you, put it in something else and see the same thing. Yeah. You know, and there's other things. We have to also find it in everybody who has it and we have to be able to like grow it and see it.
Starting point is 00:12:19 So there's a many ways. Yes, you can't see it. We figured this out. Well, we using instruments. But the point is. But with the naked eye, I just learned. We figured all that out. The way we using instruments. But the point is- But with the naked eye, I just- We figured all that out. The way we would do this is like,
Starting point is 00:12:29 sometimes we would take infectious material from people. So like tissue or spit or something gross, right? And we would pass it through a filter. Okay. To look to see if the thing that caused the disease is filterable. So right now what we're focused on is size. We don't really understand.
Starting point is 00:12:50 So we're technically right though, right? Like that isn't, that's right. We're trying to figure out. Right, it's just the mesh is too big, like the colander is too big, right? We don't have a sieve, we have a colander. So we've got a filter and we're passing material through the filter.
Starting point is 00:13:03 And what we started to figure out is that some things were caused by filterable agents and some things were caused by unfilterable agents, right? And that was sort of our initial understanding of viruses and bacteria. Bacteria, generally speaking, are bigger. Now the study of virology has evolved and there are bigger viruses than we initially thought. But the point is, generally speaking, if it passes through the filter, it's a virus.
Starting point is 00:13:30 If it doesn't, it's a bacteria. Again, this is a massive generalization. But this was our early understanding of what caused different diseases. Did it pass through the filter or not? There was toxins also passed through the filter so this would cause problems. But by the way, initial filters that we used,
Starting point is 00:13:50 the first ones were diatomaceous earth. Do you know what that's made of? Because I didn't know until I researched this. What? Do you know what diatoms are? No. They're a kind of like algae. Yeah. A very tiny algae. Yeah.
Starting point is 00:14:06 Diatomaceous earth. Yeah. Is the fossilized remains of diatoms. Which are? It has accumulated, it's kind of algae. They have accumulated over millions of years. It's largely, it's almost like glass. It's largely like silica is what's in this substance.
Starting point is 00:14:26 But it is why you can look up, if you wanna look up an electron microscope picture of diatomaceous earth, it is a wild thing to see. Okay. But I just didn't know this. Diatomaceous earth is also, the other thing that's very interesting about that. What?
Starting point is 00:14:44 What do you think of for diatomaceous earth these days? What are you using your diatomaceous earth for around the house? I don't use it for anything, but there are some people in the shelter who try to use it to keep bugs away. You know what, you actually do use it for every day to put your dishes on.
Starting point is 00:15:02 We use diatomaceous earth drying for, and for like, for dishes, I put dishes on. We use a diatomaceous earth drying for dishes. I put dishes on it because it's extremely hydrophobic. It's the fossilized remains of algae. That's so cool. And now I put my Disney on ice cups on it and it helps them dry. Amazing. Thank you, algae.
Starting point is 00:15:21 I just stepped out of you from the shower to the floor and didn't slip slide around Even millions of years later. You're still doing me a solid. Thanks algae. I Mean, I think it's pretty cool. I didn't know this and maybe maybe everybody listening already knew this about diatomaceous earths But eventually we switched to porcelain filters porcelain filters work better So in case you're curious those are the kind of filters And then we have other ways of separating it out now, but this is our early understanding. And what was confusing about this bacteria
Starting point is 00:15:52 is that it's really tiny. It's a very tiny, filterable bacteria. And so it was originally thought to be a virus, probably. We couldn't see it, we couldn't find it, but it passed through a filter. What is it? And so it took us a while to find out about mycoplasma. It took longer, for instance, than like,
Starting point is 00:16:10 streptococcus can cause pneumonia, a certain kind of strep bacteria can cause pneumonia. We figured that out earlier. It took us longer to discover mycoplasma because it's just this little teeny, it's like the smallest living, free living thing are in the mycoplasma world of bacteria. And the way that we initially encountered it,
Starting point is 00:16:31 there were other kinds of mycoplasma that caused diseases in other creatures, but in humans in the 1930s in the US, there were these cases of an atypical pneumonia and the way they distinguished it at the time, the way they would call it either typical or atypical, was based on its responsiveness to a certain kind of antibiotic.
Starting point is 00:16:50 At the time we didn't have, where this is pre-penicillin, so all we have are the sulfonamides, penicillin would come along within the next 10 years or so. But we could treat a lot of pneumonia patients with sulfonamides, we couldn't treat this kind of pneumonia with this antibiotic.
Starting point is 00:17:08 So we called it an atypical pneumonia, it's atypical. All the other pneumonia's respond to this, this one doesn't seem to, it's different. It looked pretty similar. Why are we so sure, like why is it still a pneumonia? You know what I mean? Like why are we so sure that it was the same thing that it wasn't something else?
Starting point is 00:17:23 Infection of the lungs. Pneumonia justfection of the lungs. Pneumonia just means infection of the lungs. And so you can get a viral pneumonia, bacterial pneumonia, fungal pneumonia, and you can do, by this point we have x-rays. So you can see that, you got the clinical pictures. So you've got cough, fever, chills, you're weak,
Starting point is 00:17:39 you're tired, you're sore throat, headache, the whole thing, you look like you have pneumonia, your lungs sound like you have pneumonia, your lungs sound like you have pneumonia, the x-ray looks like pneumonia, but you're not getting better the way we expect you to. So we know there's something else. It's small, we think it's a virus at first in the 30s and 40s because it passes through
Starting point is 00:17:57 what was the best filter at the time, the Seitz filter was the best one to remove bacteria and it wasn't removing this, so we didn't think it was bacteria at first. And then eventually, Eaton was the scientist who was able to take whatever was growing, whatever they were taking out of people with this illness and put it in cotton rats and then hamsters
Starting point is 00:18:19 and then chicken embryos. And all of those things got sick, or he grew more of it, but he still hadn't proved it in humans. So for a while actually, it was called the Eaton agent. Mycoplasma was known as the Eaton agent because Eaton was the closest to figuring out what this thing was. But the final thing we needed to do
Starting point is 00:18:39 in order to prove that mycoplasma was causing these different cases of pneumonia was to put it in some humans and see them get sick. Ethically dicey, right? We're gonna do it anyway. Oh, you and me? Well, not us, but humans.
Starting point is 00:18:56 But first we gotta go to the billing department. Okay, let's go. The medicines that I still make my coffee for the mouth Well, it sounds like we're in store for another one of Humanity's classic cut-ups. Sid, I'm so excited. What do we get into this time? So, as I was reading through the history of the discovery of mycoplasma, and at first, Justin, I gotta be honest, I'm researching this because I feel like it's an important thing for us to talk about and I'm not finding something fascinating to latch onto or like something weird.
Starting point is 00:19:33 And then I started reading about when we finally, and we have done this, there is an ethical way to go about actually taking something that we believe causes disease and intentionally inoculating, making people sick with it. There is an ethical way to go about that. We have established that in society. Obviously we have also done it in many unethical ways.
Starting point is 00:19:56 Super duper. But there is a path for that. And so this is not unprecedented, but that's what I was looking for were what I kept finding referenced in different articles as the Pinehurst trials. What were the Pinehurst trials? I wanted to know because this was the moment where we actually got volunteer subjects to put this eaten agent in and see if they got
Starting point is 00:20:20 sick and proved definitively that this was the cause of this atypical pneumonia. So back during 1944 and 1945, which there may be some other major world events you might remember, well, not remember personally, but probably have learned about. World War II. Exactly. During World War II, specifically atypical pneumonia
Starting point is 00:20:42 was actually causing quite a problem for the US Army and probably a lot of other people, but specifically for the US Army. A lot of people are getting sick, and again, even though for most people who get walking pneumonia, they're not going to die, you're sick for a while. I had it back in college, and it was like two miserable weeks.
Starting point is 00:21:02 I was still able to go to class and do the stuff I had to do, but it felt awful. And if you're in the military, I imagine that's a much bigger deal that you feel that bad. So they wanted to do a study through the military to figure out what is causing this pneumonia definitively and can we do something about it? So they created the Commission on Acute Respiratory Diseases
Starting point is 00:21:25 as a way to study this. And then during the summers of 44 and 45, they got four groups of 40 men to come to the Holly Inn. This is near Fort Bragg in North Carolina. To do this study. Now, how did they find, this was where Fort Bragg in North Carolina. Okay. To do this study. Now, how did they find, this was where I finally pieced together, where did they get these guys?
Starting point is 00:21:51 Justin, they were conscientious objectors. What? These were people who were conscientious objectors to the war and had been jailed because you can't do that. Right, there's draft. Yes, and so instead of going to jail, they were sent to be subjects in this experiment.
Starting point is 00:22:17 Now they volunteered. I'm not suggesting that they were coerced, except in the sense that- They definitely were. Well, I don't mean, I don't mean, well, no, I mean, they were coerced, except in the sense that... They definitely were. Like, what is that? I don't mean, well, no, I mean, they were coerced. But I mean, I'm not saying like they did agree to it. Yeah.
Starting point is 00:22:35 I mean, yeah, I understand. I think we all understand the distinction that you're making. I wanna paint the right picture. I don't wanna paint a picture of people being forced, I mean, cause you're going to give somebody a bacteria. You're going to put an infectious agent in somebody's body. I think I just wanna paint the right picture of this. Right?
Starting point is 00:22:55 So anyway. This is one of many bad outcomes that was available to them, but there were other bad outcomes that they could also have experienced had they not chosen this bad outcome. And the reason they were called the Pinehurst trials is because they were all in the Pinehurst area around Fort Bragg, because there were so many people there
Starting point is 00:23:11 because World War II was happening. So anyway, so basically they took these guys to this hotel and put them there and then they would take material, infectious material, from patients who had this pneumonia. So take washings of their airways, of their throat, swabs from the back of their throat, take material and then put it in these. It ended up being 12 subjects and wait and see if they got pneumonia. And they would hang out in this hotel waiting to see if they got pneumonia and then to monitor
Starting point is 00:23:49 the course of their disease. And of course they were provided with medical services and support. They weren't just observed. But they were very intentionally given pneumonia. They did, by the way, did not receive any pay for this. And they did have to sign a waiver that said, and if anything goes wrong. We're not, yeah. Yeah, the US Army is not responsible for any of this.
Starting point is 00:24:15 So there's a fascinating story to this, I found. Sorry. Yeah, go ahead. I would like to hear your fascinating story. And if the question will be answered later, let me know. I know that for testing that we do now, there is a board that has to, right? Like there's like standards that people have to adhere to and there's like approvals and like a process
Starting point is 00:24:40 that you have to go through, right? This is, do I have this correct? I don't know the name of the- Yes, the Institutional Review Board. Right, okay. Do you know the extent to which that sort of process exists within the military? Like is the military adhere to those standards?
Starting point is 00:25:01 Are they super military or are they, you know, like we have things like the Geneva Convention, right, that ostensibly people adhere to because there are tenants that we uphold. Is there a similar thing for, obviously, for research? This is a good, in terms of timing, this is a good question. Well, first of all, the Institutional Review Board, the IRB guidelines around any kind of human research apply to everybody now, now, in this time period. So military or otherwise, you can't do this without IRB approval, period. In 2024.
Starting point is 00:25:39 In 2024. That was not established until 1974. So at this time, we're in 1944 and 1945. The precursor, by the way, to the IRB, and I don't mean direct precursor, I mean the set of guidelines that we were supposed to follow prior to the IRB in 1974 were actually established in 1945.
Starting point is 00:26:04 It's the Nuremberg code. And it was in response to a lot of unethical, of course, you know, I don't even wanna use the word research that was being done during World War II. And it was certainly not in response to this Pinehurst trial. But I think you could point to this as another example of, while it's hard, definitely they were coerced
Starting point is 00:26:29 in the sense they had two bad options and they were choosing the lesser of two evils. They did, it was very brave that they signed up to become infected with something. Sure, yeah. And contribute to it. So I don't wanna say, I mean, I don't wanna undermine the significance
Starting point is 00:26:47 of their contribution. I mean, that's why we're trying to- I mean, they're people, and their stories deserve to be told, and they did this, and they got sick, and they did get better. I mean, I also don't think, Sid, that it's, I think that sometimes, something that I have been guilty of,
Starting point is 00:27:02 I think that it's okay for us to just say what happened. You know, like, we don't need to, I think I feel an instinct to try to like, a lot of times on Saw Bones, try to like pass judgment on something that's pretty complicated and that I don't fully understand. So, but I think it's okay to not say, you know what I mean?
Starting point is 00:27:22 Like, I don't know. Right. There's a lot, it's a very complicated thing and it's hard to just do kind of a drive by judgment on everybody involved in the situation. I know, and I think that this is beyond the scope of our show to discuss all of the different kind of ethics people were, personal ethics people were following
Starting point is 00:27:41 throughout this whole story. I mean, cause we are talking about World War II. And so I think a conscientious objector in the setting of World War II is a- It's hugely complex. That's a huge, right? I'm not gonna sit here and tell you definitively this is where history has weighed in on any of this.
Starting point is 00:27:57 I mean, certainly not me. I don't have that moral authority. It did happen. It did happen. No, but I read it was really hard to find a good history of this exact event. The Pinehurst trials are mentioned multiple times in different articles about the history of microplasma.
Starting point is 00:28:15 So it's not hard to find that they existed, but to get into like, who were these men and how were they chosen as subjects? Well, this is how, and how did this come to be? That was actually kind of hard to find. I finally found this article that was in the, it was in the news and record in Greensboro, and it was called Lonely Valor,
Starting point is 00:28:39 Some Objectors Served as Medical Pigs. And this is from 1995. Guinea pigs, I assume they mean. Guinea pigs is what they mean. They mean gu medical pigs. And this is from 1995. Guinea pigs, I assume they mean. Guinea pigs is what they mean. They mean Guinea pigs. But it's an article. Parliament chairs were hard to come by in those days. It is an article about the history
Starting point is 00:28:53 of the conscientious objectors who were coerced into participating in this experiment and the sacrifice that they made in terms of allowing themselves to be sick was something that we didn't have all the tools to know how to treat at the time. We didn't know how to cure it. And there's a whole history of that.
Starting point is 00:29:12 They wrote poems while they were stuck there looking out the window at people outside enjoying the summer weather and they're in isolation for two months waiting to see if they get pneumonia. Anyway, it was a definitive moment in proving that this was the causative agent. The poem's also, nothing rhymes with pneumonia,
Starting point is 00:29:31 so you can imagine. So that's tough. That's like, it's a tough. After we figured that out in the 40s, by the 50s, we started to be able to figure out how to grow this thing. It took a while, it was the 50s and 60s, before we were able to fully grow it. Some things are harder to grow than others, and that's why we can test, we were able to test for some things a lot earlier than we were able to test for others.
Starting point is 00:29:54 And it was another like 20 years before we finally said like, yep, the Eaton agent is mycoplasma, it is a bacteria, it is this small. And it led to this whole, in the 70s, this whole like field of mycoplasmology arose from this because this was kind of a whole little subset of bacteria that nobody had really understood yet because they were so small, they had all been misidentified as viruses. And so it led to the International Organization
Starting point is 00:30:25 of Mycoplasmology and the first international Congress of Mycoplasmology in the 70s. There's some great pictures from this of a lot of, they're all guys, I think, in like fancy robes and hats at their first Mycoplasmology conference, which, and by the way, it still exists today. I think the next one is in Poland in 2026, will be the next Congress of Mycoplasmology,
Starting point is 00:30:47 because it is a very unique subset of living organisms. Yeah. It's gonna be a killer one this year. I heard Chappell-Rones closing it out. It's gonna be like two days of just like madness, yeah. They call them, they used to call everything in this group Mycoplasma, now they've expanded it
Starting point is 00:31:06 to other names, other genuses. You get a better hotel rate if you expand the conference to a lot more. But they're all called molecules. That is molecule. They're molecules, they're molecules. Anyway, so what do you need to know about walking pneumonia after all this strange and challenging history
Starting point is 00:31:26 that we've covered? So for most of us, you are gonna get like a, what we call like a tracheobronchitis, meaning an infection in your airways, but not necessarily in the lung tissue itself. Once it gets to lung tissue, that's when you have a pneumonia. And some people will develop a pneumonia.
Starting point is 00:31:44 So some people get like a bad bronchitis, that's mycoplasma, other people get sick enough it continues on and they actually have a pneumonia. Cough, fevers, chills, body aches, sore throat, headache, the usual stuff. There are some severe complications that are more rare that can happen to some people but for the most part this is what we're talking about. And again, for most of us, you can quote, walk around with it. So it is walking pneumonia. What has been interesting, oh, and treatment.
Starting point is 00:32:12 The treatment is something you may be very familiar with. For most of us, we will receive azithromycin or what you may call. A Z-pack. A Z-pack, yes. A Z-pack is dosed to treat walking pneumonia, or atypical pneumonia, or mycoplasma pneumonia, whatever you prefer to call it.
Starting point is 00:32:29 There are some backups if you're allergic to that or for some reason you can't take it, you can take a fluoroquinolone like Levoquin, you can take doxycycline, my favorite antibiotic, depending on age and pregnancy and all other factors, all the things we consider with antibiotics. So it is something that we know how to treat now that explains why initially it didn't respond to it doesn't have a cell wall, so it didn't respond to the
Starting point is 00:32:51 Old antibiotics are not old at the older as in they came along first antibiotics that we used to use for pneumonia Wouldn't work on this so That's why we had wait till we had macrolides, which that's what is it for my son That's what what class it iscin, that's what class it is in. So what's different this year is, one, we're seeing more cases than last year, and two, we're seeing it in younger children than usual. Anybody can get it, but the peak is usually school age,
Starting point is 00:33:21 adolescent, moving kind of up into young adult. It's all those years where you're crammed in schools together, right? I got mine when I was living in a college dorm, makes total sense. But this year we're seeing it in kids younger than five. So pre-school, not preschool, you know what I mean, prior to school age children.
Starting point is 00:33:38 And that is a little more unique. Now, why would that be happening? Well, there are several reasons. And I actually, as I was researching, why is there a rise now, I found an article from last year sort of predicting that this was going to happen. Why?
Starting point is 00:33:53 For one, we saw a suppression in rates of all respiratory viruses during COVID. Right. Why? Masking, social distancing, et cetera. All the mitigation techniques we used. The mitigation mitigated. The mitigation mitigated everything.
Starting point is 00:34:10 And so we saw lower rates of a lot of other respiratory illnesses. That's why in many countries, they take those precautions and keep people from getting sick. Yes. Yeah. And so it was natural that we saw that
Starting point is 00:34:22 and mycoplasma was among the respiratory illnesses that we saw decreased numbers of. Itma was among the respiratory illnesses that we saw decreased numbers of. It was one of the last to come back. It was one of the, in terms of as we saw the rise of all these other viruses, I think you remember RSV, we were having the same conversation about last year. So this was one of the last ones to sort of rebound, but that's part of it. We kind of figured it would rebound as everybody finally stopped engaging
Starting point is 00:34:49 in those mitigation techniques. Not that everybody has, there are still some people doing that, but I think in a mass sense. Not in the scale that. Not in the scale needed to mitigate. Right. Public health-wise, not personally.
Starting point is 00:35:00 And the other thing is that there is a three to five year cycle naturally with microplasma where we see bigger surges and then years where there's less And so we have fewer people exposed for a few years Then now all of a sudden more people get it and we've got younger people who had not been exposed previously You're now getting exposed it all kind of makes sense as to why this is happening There's also some testing differences that are that are interesting microlasma used to be a lot harder to test for. Now I know at all the facilities I work at,
Starting point is 00:35:30 it's on the standard respiratory virus panel. So it's not a virus, but it is on a respiratory virus panel, which I always think is interesting. Yeah. When you, and initially a lot of us were ordering- Now I did too, Syd. It is interesting. Yeah. Initially, when COVID started, we were all ordering a COVID test, And initially a lot of us were ordering. Now I do too, Syd. It is interesting.
Starting point is 00:35:45 Initially when COVID started, we were all ordering a COVID test and then COVID got added to our respiratory viral panel. So instead of ordering a COVID test, if someone suspected COVID, they would just order the panel. And we can all debate whether economically that's a good idea or not.
Starting point is 00:36:00 But the point is it's happening. I wonder if that's also why we're picking up more Mycoplasma. Because we're catching it more. So we're testing more. That could be it too. But all of these things contribute to the fact that we are seeing an increase in cases. We kind of knew this would happen. So I don't think it's something to worry about in that sense. What I would do is engage in the same sort of strategies that help us prevent illness of any kind of
Starting point is 00:36:26 respiratory droplet illness. So it is transmitted that way, respiratory droplets, coughing, sneezing, not washing your hands, getting that infectious material on other people. So washing your hands, covering your mouth, staying home when you're sick, not sharing you you know, beverages with people who are ill, wearing a mask if you're going out in public if you're sick, or if you are somebody who's particularly concerned about getting a respiratory illness, keeping your kids home when they're sick,
Starting point is 00:36:55 staying home from work when you're sick. I mean, staying home when you're sick is a really big part of all of this. And then it is a time of year where, especially if you're somebody who is especially vulnerable to these kinds of illnesses, to avoiding crowds whenever you possibly can. Obviously that is something we can only do
Starting point is 00:37:10 to whatever extent we can. Yeah. But that is what's going on. If you do contract, and I'm not suggesting that if you get a cough and a fever, you should immediately run to the doctor every time. Certainly not everybody always needs to do that. You know your own health history better, maybe you do,
Starting point is 00:37:28 but you know, not everybody always needs to. But if you are sicker, then you know, you'd expect with a common cold, right? Then you'd expect with a runny nose, cough kind of thing. Certainly go get checked out. If your young child is ill, certainly go get checked out. If you again, have some sort of other coexisting condition that makes you more vulnerable, go get checked out. If your young child is ill, certainly go get checked out. If you, again, have some sort of other coexisting condition that makes you more vulnerable, go get checked out.
Starting point is 00:37:50 If something is lasting longer than you expect it to, we usually expect a virus to last like seven to 10 days and then you're pretty much better. If you're still sick, I always tell people, if it's going on a week and you're just as sick as you were in the beginning, you need to get checked out, or certainly if you're getting worse. And you might see that your doctor's a little quicker
Starting point is 00:38:07 to prescribe something like a Z-Pak because we know there are increased rates of this right now. So if you're concerned, go get checked out. There is a test for it, and also a lot of it is clinical picture. We can just tell based on your exam and your history. Thank you so much for listening to our podcast. We hope you have enjoyed yourself.
Starting point is 00:38:28 Thanks to taxpayers for using their song, Medicines, as the intro and outro of our program. Thanks to you for listening. That's going to do it for us. Until next time, my name is Justin McElroy. I'm Sydney McElroy. As always, don't drill a hole in your head. Music Alright! Yeah! Maximum Fun
Starting point is 00:39:00 A workaround network of artist-owned shows supported directly by you.

There aren't comments yet for this episode. Click on any sentence in the transcript to leave a comment.