Science Vs - Peptides: The Ultimate Body Hack?

Episode Date: June 4, 2026

Peptides are huge right now. Influencers are telling us they can work wonders for all sorts of stuff. Struggling with an annoying injury that won't heal?? Belly fat that's pissing you off? Low energy?... Gut issues?? There’s a peptide out there for you. People are buying peptides off the internet and injecting themselves with them, saying it's life changing. But away from the internet hype, there is actually a potential revolution happening in medicine around peptides. So we’re finding out what scientists are excited about here, and we look deeply at the science behind two massive peptides: BPC-157 and MOTS-c. And we’ll also look at the risks: Could peptides give you cancer? On this episode we talk to Dr. Hassy Cohen, Dr. Keith Baar, Dr. Dhruv Khullar and Dr. Cory Mayfield to get to the bottom of this. Find us on Youtube! We're at https://www.youtube.com/@ScienceVsPodcast  Find our transcript here:https://tinyurl.com/ScienceVsPeptides In this episode, we cover: (00:00) Peptides are everywhere right now (03:56 ) What are peptides? (04:39 ) The peptide revolution in medicine (09:56) MOTS-c: Should you take it? (15:56 ) BPC-157: Can it heal you? (26:33) What are the risks? This episode was produced by Wendy Zukerman, with help from, Rose Rimler, Ekedi Fausther-Keeys, Meryl Horn and Michelle Dang. We’re edited by Blythe Terrell. Fact checking by Diane Kelly. Video editing and sound mix by Bobby Lord. Music written by Bumi Hidaka, Peter Leonard, Emma Munger and Bobby Lord. Thanks to the researchers we spoke to for this episode including Dr. Dana Lis, Dr. Pouya Faridi and Dr. Timothy Piatkowski, as well as the Australian Science Media Centre. A big thanks to Joseph Lavelle Wilson and the Zukerman family.  Science Vs is a Spotify Studios Original. Listen for free on Spotify or wherever you get your podcasts. Follow us and tap the bell for episode notifications. Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Starting point is 00:00:00 Hi, I'm Wendy Zuckerman, and this is Science Burses, the show The Pits Facts Against Internet Phenomena. Today on the show, peptides. Here are the top five peptides I'd recommend to glow up before summer and flex on your ex, respectfully. Well, then you know that peptides are everywhere right now. Peptides, you want to know more about peptides? Look at my stash. I'm really into peptides. Peptides are huge right now.
Starting point is 00:00:30 No matter what you're struggling with, an injury that won't heal, belly fat that's pissing you off, low energy, gut issues, there is a peptide for you. People are buying this stuff off the internet, injecting themselves with it, and saying that it's life-changing. I have never been this confident, felt this good, looked this good, you want to be on these. For the uninitiated, there are many different peptides out there that people are injecting. But one of the biggest and most popular is called BPC. 157. It's a fan favorite of Joe Rogans, Andrew Huberman has injected it into his back. People often take it alongside another peptide in what's known as the Wolverine Stack. Not so much because it makes you hairy, I wish, but because it's supposed to help heal injuries fast.
Starting point is 00:01:20 There's one peptide that seems to be good for everything, and that's BPC 157. BPC 157 is primarily known for healing, but it has a massive. ability to heal your guts as well. It's so effective. I mean, I can't even begin to tell you. Another popular peptide out there is called MOTC. Folks on it are saying they're losing weight, getting energy, and they reckon it's even going to make them live longer.
Starting point is 00:01:47 There is a peptide that works like a workout you never actually did, and it's called MOTC. You are leaner, you are more vascular, and your muscle definition is better. My eyes are like open, wide. my rain is fiery. I am so clear. Guys, it's like you have unlimited energy. But not everyone is so excited about peptides. There are the peptide heretics out there
Starting point is 00:02:17 that say, you are injecting what now? This is a bad and potentially dangerous idea that could apparently even increase your risk of cancer. Those pet pies are going to kill you. Those pepies are going to kill you. What are you even doing? And where did this come from? And who told you this was a good idea?
Starting point is 00:02:39 Every time I log in, there's another influencer in my feet raving about some compound. They probably heard about on a podcast three weeks ago. A podcast? Who me? Today on the show, can peptides heal you? Well, they really put a peptide in your step. And the truth is that away from the... internet hype, there is actually a potential revolution happening in medicine around peptides.
Starting point is 00:03:05 So today on the show, we are going to find out what scientists are excited about here. We're going to look deeply at the science behind these two massive peptides, BPC 157 and MOTC. And I know there are a bunch of other peptides out there, so if you want to know the science on those, just let us know in the comments. And finally, we're going to look at what are the risks here? Are those peptides going to kill you? When it comes to peptides, there's a lot of... It's so effective.
Starting point is 00:03:35 But then, there's science. Science versus peptides is coming up, just after the break. Visit BetMDMGM Casino and check out the newest exclusive. The Price is Right Fortune Pick. BetMDM and Game Sense remind you to play responsibly, 19 plus to wager. Ontario only. Please play responsibly. If you have questions or concerns about your gambling or someone close to you,
Starting point is 00:04:07 Peace contact connects Ontario at 1-866-531-2,600 to speak to an advisor, free of charge. BetMGM operates pursuant to an operating agreement with Eye Gaming Ontario. How can working at your local Tims take you further? Sure, you can level up your teamwork skills. You also get a chance to receive a Tim Horan scholarship award. Ready for what's next? Apply today at careers.timhorins.ca. Welcome back today on the show, Science versus Peptides.
Starting point is 00:04:45 And the first thing you have to know is what on earth peptides are. So peptides are short chains of amino acids strung together. And you can think of them as small proteins. In fact, some scientists even call them micro proteins. There's thousands of peptides swimming in your body, and some do very important things, like insulin. That is a peptide. Another peptide?
Starting point is 00:05:13 GLP-1s. The blockbuster weight loss drugs, they mimic an important peptide in our bodies that regulates blood sugar and helps make us feel full. So peptides are real things in science. But to know more about the current hype and what scientists are pumped about here, we need to meet this guy. Hey there. Hi. My name is Hasi Cohen. Hassie Cohen is a professor of gerontology at the University of Southern California.
Starting point is 00:05:42 And he thinks we are at the cusp of a revolution. when it comes to peptides. And to understand why, we need to go back. To a time when, perhaps, you felt like you were personally victimized by Regina George. Lose my breath by Destiny's Child as playing on your MySpace page. Maroon 5 isn't quite so irritating. And the human genome has just been decoded. That's right.
Starting point is 00:06:11 It's 2004. An international team of researchers announces that after 13 years, they've found all the genes hidden in our DNA. And if you need some biology 101, genes are instructions that tell your body to make proteins, proteins like hemoglobin or collagen. And Hassey remembers finding out just how many genes there are in the human body. People said there are 20,000 genes. That's it.
Starting point is 00:06:41 and they do everything, which I always found to be a little bit mysterious. I didn't really think this could be true. Hassey figured that humans are so complicated, some 20,000 genes to make everything in your muscles, bones, brain, eyeballs, sphinxes. Even at the time, one headline said this was unexpectedly low. And back then, there were clues
Starting point is 00:07:11 that there's more to us than that. So when you look at our entire DNA, you roll it out like toilet paper. Those 20,000 genes are a tiny fraction of the roll. There's 3% of the DNA. 97% of the DNA until 20 years ago they used to refer to as junk DNA. Ah, that's where these peptides are coming from,
Starting point is 00:07:37 the so-called junk DNA. Many of them. That's so cool, because And some of the famous peptides that people know about are thinking insulin, DLP1, they're not coming from junk DNA. Right. But where we're discovering these sort of cool new peptides, these some of those are from junk DNA.
Starting point is 00:07:58 Yes, yes. For years, that's so-called junk DNA, and more generally the parts of our DNA that didn't code for proteins. It was like a cipher that many scientists, including Hussi, were trying to decode. And over the years, they worked out that these mysterious chunks of DNA do loads of important stuff,
Starting point is 00:08:19 including, get this, coding for not big, complicated proteins, but little baby proteins. Peptides. Nobody expected a small protein to come out of that. But fast forward to today, and Hasi's team has found a bunch of peptides hanging out in weird parts of our DNA.
Starting point is 00:08:42 His lab likes to give them Yiddish names. Please tell me there's one called Khutzpah. We don't have chutzpah yet, but we have munch. We have mench. Mesh. Schlep. Shmooze called mazel, like mazzledas. Pats. We're just having fun.
Starting point is 00:08:58 Hasse's lab has found these peptides in what's called our mitochondrial DNA. Mitochondria are known as the powerhouses of ourselves. They kind of look like carpetbrile. beetle larvae, but what they do is pump out fuel for our body to use for energy. And in humans, different versions of Hasse's mitochondrial peptides have been linked to lowering our risk of various diseases. Alzheimer's, Parkinson, diabetes, obesity, cancer. In lab and animal studies, these peptides can affect muscle growth, metabolism, oxidative
Starting point is 00:09:35 stress, insulin sensitivity, and cognition. And we just keep finding more peptides. A study published in May this year found more than 3,000 peptides hiding in the mysterious chunks of our DNA. And we're not sure what many of them even do. Hussie is excited that there is this whole world of tiny proteins, actors in the human body that we didn't even know existed.
Starting point is 00:10:02 And he reckons it could change the way that we understand some diseases, possibly opening the door to different kinds of medicine. And what this micropotein revolution really embodies is the fact that instead of 20,000 genes, we probably have a million genes. Wow! Expanding the human genome by two orders of magnitude, that is the revolution.
Starting point is 00:10:26 Yeah, wow. That is the transformative change. Another researcher told me that maybe we're not going to find that many peptides, he thought it's more like 20. 20,000, maybe 30,000. But still, that's a lot of peptides. And one of the peptides that Hasi's team has discovered completely bolted into internet fame. Motsie. That's right. The peptide from the start of the show that people are going bananas for saying that it's helping them lose weight and get energy, it is one of the top five peptides that you should try to glow up for summer and flex on your
Starting point is 00:11:03 ex, respectfully. It's Hassi's baby. Motsi is having a moment. Motzzi is having a big moment. Over the last few months, I realized this is not just kind of a curiosity. Tens of thousands of people are taking Motsi. Now, if you are racking your Yiddish trying to work out this one, it actually comes from a Hebrew prayer.
Starting point is 00:11:24 You say, Hamotsy lechem in the Arad. Get it, Motsie. So let's get into the science and find out if maybe you should start taking it. So when Hasi's team first discovered this little peptide, just 16 amino acids all strung together. We had no idea what it did. And the postdoc who was working on it just started putting out on things and injecting it into mice
Starting point is 00:11:52 and, you know, let's see what happens kind of thing. And one of the things that they did is put some mice on a high-fat diet, which would usually make them put on weight. Then they injected some MOTC into them. Well behold, they did not gain any weight. Instead of gaining weight like they should on a high-fat diet, they didn't get any weight.
Starting point is 00:12:13 And MOTC completely prevented 100% accumulation of fat in the liver of those mice. Wow. That was a big deal. Fat in the liver can be dangerous. It can muck up the liver itself, but it can also lead to things like stroke. So the idea that this peptide could prevent that from happening,
Starting point is 00:12:32 even when the mice were eating all these calories, That was potentially big. The team kept testing it. They gave older mice MOTC and they lived longer than mice on a placebo. You give mice MOTC and you put them on a treadmill that can run a lot longer.
Starting point is 00:12:53 Hussie's team worked out that MOTC might protect muscle by blocking the activity of a molecule that can break down muscle. One study found that in men having a mutated form of MOTC increased their risk of type 2 diabetes and having more visceral fat. Another study found that type 2 diabetics
Starting point is 00:13:10 with low MOTC had a higher risk of having a life-threatening cardiac event. Hussie thought, this MOTC, there really could be something here. So he started a company with a friend and they raised $80 million and ran a small clinical trial of MOTC.
Starting point is 00:13:30 They got people with a high BMI, and quite a bit of fat around their liver, had them coming to a lab. Four weeks, 20 people, you get injected typically in your tummy subcontaneously for 30 days. The people were injected with either MOTSI or a placebo. And Hussie basically wanted to know
Starting point is 00:13:49 would those getting MOTC lose more weight? Would they lose some of the fat around their liver? And here's what happened. When it came to weight loss and fat around the liver, the Motsie group did, maybe a little better, but it wasn't statistically significant. They did see some more exciting stuff, though.
Starting point is 00:14:12 There are these liver enzymes that tend to go up in people with fatty liver. Those went down, blood sugar went down, which is great. And it was pretty safe. The biggest issue is that some people had a bit of skin irritation around the side of injection. Which is not a complete deal breaker, but it was a little bit of...
Starting point is 00:14:32 knowing for the people who used it. So things were going okay, and Hasi thought that maybe this really would be a drug. In fact, he was starting to dream of larger trials with more people. But soon, a rival peptide entered the field. Ozempic became the most successful drug in history. It was a weekly drug, and our version of MOTSI at the time was a daily injection. investors told Hasi, This is not going to make money.
Starting point is 00:15:05 And ultimately, the company folded. But since then, Motsie has taken on a life of its own. You can buy it online, supposedly just for research purposes, and inject yourself with it. And people are going bonkers. Just off the back of a bunch of mouse studies, one small clinical trial, and a whole lot of hype.
Starting point is 00:15:30 That created this crazy black market use of MOTC. And I've spoken to some people who swear that they see their athletic performance improve on MOTC. Is that surreal for you? Is it so strange that people... It is surreal. It is surreal. And like I mentioned, now people are saying that they're losing fat and building muscle and amping up their energy on Motsie.
Starting point is 00:15:57 And Hasi says, you know, if you're losing fat and building muscle, and hussy says, you know, if you look at his mouse studies, maybe you could make a case for some of these claims. I mean, after all, the mice did run longer on a treadmill, but up against the hype. The research cupboard is pretty bare. After the break, we go further down the peptide rabbit hole as we dive into the science on BPC 157. Plus, could peptides really give you cancer? Coming up. Staples Preferred Business Membership, built for busy business owners,
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Starting point is 00:17:04 slash preferred. That was easy. Welcome back. Now, let's get into one of the most popular peptides on the market, BPC 157. This is the so-called Wolverine peptide, but people say it can help you recover from injuries fast. So where does it come from? And should you try it? BBC 157 stands for body protective compound 157. So, you know immediately that it was not discovered by Hasse's team. It was isolated from gastric juice in the early 1990s by a Croatian lab.
Starting point is 00:17:46 And what's curious is that humans don't actually make BPC 157. You can't find it in our DNA. So the going theory is that maybe a gut bug makes it? We don't know. But the big question is, can it heal you? For this, I called up Keith Barr, a professor of molecular exercise physiology at University of California Davis. And he told me that recently...
Starting point is 00:18:15 So I started getting a lot of emails from people asking me, so I inject BPC 157 into my tendons and they're feeling better. This is a magical thing. And I'm like, oh, that's really cool. So let's go test it. Yeah. He wanted to see if BPC 157 can really heal tendons and ligaments, which can be very difficult injuries to treat.
Starting point is 00:18:38 So it would be great if all you needed was one cheeky injection and off you go. And here's how Keith tested it. His first step is basically building a little tendon in a dish. We take cells from people who basically rupture their Achilles. They come to our medical center to get their Achilles tendon repaired. And what we do is we take the little broken piece. Keith's team takes the roughed up cells of the human tendon, embeds them in a gel, puts it all on a tiny bone-like scaffolding.
Starting point is 00:19:11 And then, yada, yada, yada, the cells will start to replicate. They make more cells. And so from that one ACL, that one ruptured ACL, I can make about a thousand little engineered human ligaments. Wow, that's so cool. The model will grow to about the size of a toothpick, and then he's ready to test it. So the team exposes the tendon to, say, different peptides
Starting point is 00:19:37 and basically sees what happens. And he told me that often it's pretty obvious if it's doing something. If you wiggle it, normally, you'll see it move a little bit. If it's stronger, it'll stay nice and stiff. If it's really weak, it'll flop around. So you can see that these things, these drugs, or these treatments are really either having an effect on the tissue or they're not.
Starting point is 00:19:59 And they've seen this with another peptide called insulin-like growth factor one. Some people, in particular bodybuilders, use IGF1 to get stronger. And in high doses, it's not safe. It can increase your risk of heart disease and cancer. But it's been studied for a long time and it can help you build a bit of muscle
Starting point is 00:20:19 and make you bigger. In fact, not just you. So IGF1, that's the difference between, say, a great day and a chihuahua. Wait, so if you gave a chihuahua, insulin growth factor one at a critical point in development. When it's very, very young, and in developing still, it will get
Starting point is 00:20:37 bigger and it will become a big chihuahua. Yeah. Okay, but away from the chihuahua, what happened when Keith put these peptides on his lab-grown tendons? And so when we treat with IGF-1, they get stronger, but when we did the exact same thing with BPC 157, it had absolutely no effect. No effect. It wasn't better, but it wasn't worse. Keith's team tested BPC 157 a different way, bathing some human cells in it to see if they replicated faster. And again, it didn't really do anything. Now, this doesn't totally put the kibosh on BPC 157. Keith has just started studying this.
Starting point is 00:21:21 He hasn't even published the data yet. He wants to keep running tests. And he says that just because BPC 157 might not do anything to his tendon in a dish. It doesn't mean that it doesn't do something when you put it into a body. So, for example, other researchers have found evidence in rats and basically petri dish studies that BPC 157 might promote something called angiogenesis. Or the production or the making of new blood vessels, supposed to increase the ability to get blood flow to whatever tissue that you're trying to regenerate.
Starting point is 00:21:59 And Keith says you wouldn't see new blood vessels popping up on what's basically a disembodied tendon in a dish. So to find out if this peptide really does increase angiogenesis and more broadly helps you heal from injuries, we really need to test it in a human body, right? Not just human flesh. So what studies do we have here? Let me tell you. So in 2015, a placebo-controlled safety trial for BPC 157
Starting point is 00:22:29 was registered on the US government's website for clinical trials. But the results were never published. Another study from 20 years ago of 46 people with ulcerative colitis, either got a BPC-157 enema or a placebo each day for two weeks. And it looked like maybe the BPC-157 group did better overall. But the thing is, most of the findings weren't significant. And then there's a doctor who, by the way, wrote a book called The Fountain of Youth with Peptides. and he has a clinic in Florida where he injects people with peptides.
Starting point is 00:23:09 And he gathered up 12 of his patients who he'd injected with BPC 157 because they had knee pain. And asked them basically, do you remember how bad your pain was? Is it better now? Nine out of the 12, so 75%, said that three months to a year later, yeah, the pain was better. Now we have no idea if the peptide was the thing that improved their knees or the passing of time, which, you know, is supposed to heal all wounds. Or perhaps it was the placebo effect. I talked about this with Dr. Dr. Dr. Kula, a physician and health policy researcher at Wild Cornell Medicine in New York.
Starting point is 00:23:53 And he told me that the placebo effect can be huge, particularly when it comes to knee pain. We know placebo effects are very powerful. People who have a fake knee surgery, they have better outcomes. Yeah, there are literally studies where doctors give someone an anesthetic, slice them open, basically stare at the ceiling for a bit and then sew them back up. And those patients felt better to the same degree as if they'd gotten real surgery. There are studies that suggest that, you know, the more expensive you think a drug is, even if it's a placebo, the more effective it seems to be,
Starting point is 00:24:31 for you. And that's true for things like Parkinson's, which you wouldn't expect. In this case, you're going through the trouble of ordering something online. There's a bunch of syringes. It's kind of scary. You inject yourself. It's expensive. It's painful. You really want this to work. So if all we've got are some uninspiring studies in people, why are folks online going through all this trouble for BPC 157? Where are all these exciting claims coming from that it'll heal your tendons and ligaments? that you'll become Wolverine. Well, BBC 157 has been used by folks in certain online spaces for a while now. So there is a lot of lived experience or anecdote, whatever you want to call it.
Starting point is 00:25:18 But if you're looking for science for all those claims about BPC 157, what we have are studies in rats. And the vast majority of those studies actually come from one particular. lab. It's the lab that first discovered the peptide in Croatia. It's the same lab that's linked to that study in people, the clinical trial
Starting point is 00:25:41 from 2015, that never published those results. But for three decades, what this lab has published are scores of studies where they'll get a rat cut its quadricep or ligament, slice its cornea, damage its nerve,
Starting point is 00:25:57 you get the picture. And then they give one group of rats a placebo, while the other gets BPC 157, and over and over and over again, the team finds that the rats injected with BPC 157 do better. I called up the professor that heads up that lab, but he wouldn't go on the record to talk. And once I started asking,
Starting point is 00:26:23 why didn't he publish that clinical trial from 2015? He ghosted me completely. So that's BPC 157. And like I mentioned, there are other peptides out there that are supposed to help you hulk up and recover faster. But a review paper looking into some of the most popular ones basically concluded, there's pretty much no evidence in humans for this. I spoke to one of the authors of that paper, Dr. Corey Mayfield, a resident at Keck School of Medicine, It was more shocking on that front than to learn that how little research there had actually been. Going in, what did you think you were going to find? We had thought there would probably be more, at least, evidence supporting the use of these. I don't think there's really any other therapy that we see that has less evidence that's more used.
Starting point is 00:27:20 So here's where we're at. Online, you are going to read and see these amazing stories of people juicing up with peptides and feeling so great and healing so quickly and popping with muscles. But if you are looking for scientific evidence that peptides are doing that magic and not the placebo or something else, you are going to be bitterly disappointed, as I kind of was.
Starting point is 00:27:48 But this takes us to the last question of the episode. What are the risks? If you've got a knee injury that just won't heal or you want to build extra muscle fast, and you want to give this stuff a go. Are there any downsides? Well, if you try this, you will be injecting yourself, so you need to be careful because you could get a nasty infection.
Starting point is 00:28:11 And they use the odd case report of bodybuilders using unclean needles to inject steroids and then getting infected with hepatitis C or HIV. And on Reddit, you will see people injecting themselves with peptides and then some body parts swelling up like mad and needing antibiotics. Also, if you're giving yourself repeated injections, you need to worry about lipohypertrophy,
Starting point is 00:28:35 which is a build-up of fatty rubbery lumps under the skin. Away from the needles, another issue is, how do you know what's in the vial? Right now, in the US, you can't buy a lot of these peptides at a pharmacy. You get them online, right? And Dr. Drav Kula, the physician at Wild Cornell Medicine in New York, recently bought some peptides
Starting point is 00:28:56 to find out exactly what was in them. It was for an article that he wrote for the New Yorker. Oddly, just as an aside, on one of the websites, they gave him a little bonus. And when I was checking out, they just added 30 capsules of this synthetic hormone called demoxetocin for no reason, which doctors usually use her inducing labor
Starting point is 00:29:17 or treating postpartum bleeding. What? Just like, hey, are there some other drugs you might like, I guess. No matter. within a week, the peptides started arriving. What did it look like when it arrived? Oh, it was just, it's usually just a white powder, you know. It looks maybe like some flour or cocaine.
Starting point is 00:29:35 Okay. You know, depending on that while you're most familiar with. Yeah. Trump, I didn't know you'd make that joke. I was ready to make it, but you got in there out in front of me. All right. He took these peptides into a lab that tested what was inside. And the results found that one of the vials had the right peptide at the right dose.
Starting point is 00:29:54 Another vial contained endotoxins, which are bits of bacteria, possibly from contaminated water in the manufacturing process. Another vial had less than half the advertised dose. And? I got one vial that had lead in it. I prefer my medications without lead. Yes, lead. And then people would be injecting it into themselves.
Starting point is 00:30:22 Not great. Now this is of course just Drub's experience. Maybe he got unlucky. We don't have studies analysing what's contained in the peptides that people are buying online. Researchers are on the case though. But what we do have are studies on a similar illicit market, anabolic steroids. One Australian study of more than 100 samples found that 22%,
Starting point is 00:30:46 so 1 in 5, were mislabeled. And they could also be contaminated with heavy metals from lead to arsenic. I asked Drove what the lab he tested his peptides at was seeing. Broadly, what did they tell you about how many of the peptide samples that they test have issues with them? They estimated somewhere between 10 and 20% of the samples they receive have significant issues, whether of dosing or purity. When you're ordering these unapproved drug online, you don't really know what you're getting. It's just like a box of chocolates.
Starting point is 00:31:18 Exactly, exactly. Basically, in this unregulated market, these peptides are coming from factories where the quality control is not up to snuff. Now, this may change in the US soon. The FDA is meeting in July to talk about letting compounding US pharmacies make a handful of peptides, including MOTC and BPC 157 and then sell them directly to the public. Of course, that's not going to make them effective, just less likely to have lead in them. But there is one more risk that we need to talk about, and that is around cancer. Like I mentioned, some peptides are supposed to work by encouraging blood vessels to grow.
Starting point is 00:32:02 And this, in theory, could increase your risk of cancer because giving cancer cells a blood supply gives them the nutrients to survive and spread. I talked about this with Dr. Corey Mayfield. I know anyone who would have had a scan for some weird thing in their body, one of the tests for is that weird thing cancerous? Are they blood vessels around it or not? Correct. Yeah, that's the main thing we look for is, you know, is it getting blood, is it new blood?
Starting point is 00:32:29 It's like, is it pulling in its own blood supply? And that's what we worry about. We don't know for sure if this is a risk or even if some of these peptides increase angiogenesis in the first place. But the thing is that if peptides actually do what people are saying they can, if they are modulating your body in all of these different and exciting ways, they probably will have some side effects. I mean, think about the peptides that we have good research on.
Starting point is 00:33:02 So, GLP-1s, for example, they work really well. But if you're losing a ton of weight, you need to worry about muscle loss. They can also cause nausea and diarrhea and rarely gut paralysis. IGF-1, like I mentioned, can increase your risk of cancer and heart disease. None of the doctors and researchers that you heard from in this episode, Drav, Corey, Keith, and Hassee, inject themselves with peptides. I talked to Hassee about why he's not injecting Motsie. And let me say that I am coming of age, and I'm very worried about my muscle loss, my sarcopenia. I'm worried about this.
Starting point is 00:33:41 If Motsie was approved, I would take it right now. Will I ever take it? I don't know. At the moment I'm not taking it. Why not? Because I don't trust. I don't trust the stuff that people are taking out there. I don't know where they're getting it, how it's mixed, how it's prepared.
Starting point is 00:33:57 But you could, you could act. You're one of the few people out there that could actually get MOTC and know you're getting MOTC. But you still don't take it. It's true. Why not? Because I'm an old-fashioned traditional guy. And, you know, when you're raised with values as a physician scientist, you know, all the supplement universe is.
Starting point is 00:34:18 is something that you really disrespect. And the majority of supplements is a multi-billion dollar business. Almost all of them don't work. And I've always said to myself, why are people doing it? They don't know. There's no evidence. So I come from a place of a traditional, old-fashioned physician scientist
Starting point is 00:34:39 who believes there's a right way to do it and a wrong way to do it. And while I get the impulse to want to be your best self, and I know how frustrating it is when injuries take a long time to heal. And I also think that the potential peptide revolution happening in science land, it could be super cool. But at the same time, injecting yourself with stuff that some influencer, or worse, podcaster, is selling you online. As Hassee would say,
Starting point is 00:35:15 it's the wrong way to do it. I guess I'm old-fashioned like that too. That's science verses. This episode has 73 citations in it and if you want to see them in all of their glory then you can look at the show notes and link to our transcript. It is a fully cited transcript. So if I said anything and you think, wait a second,
Starting point is 00:35:42 go check it out for yourself. This episode was produced by me, Wendy Zuckerman, with help from Rose Rimler at Ketti Foster Keys, Merrill Horn and Michelle Dang. We're edited by Blythe Terrell, fact-checking by Diane Kelly, video editing and sound mix by Bobby Lord. Music written by Bumi Hidaka,
Starting point is 00:36:04 Peter Leonard, Emma Munga and Bobby Lord. Thanks to the researchers that I spoke to for this episode, including Dr. Dana Liss, Dr Puyaforidi, and Dr. Timothy Piatkowski, as well as the Australian Science Media Centre. Thanks for all the papers. A big thanks to Joseph Lovell Wilson. and the Zuckerman family.
Starting point is 00:36:20 Science versus is a Spotify studio's original. We are also now on YouTube. Yeah, you can find us at ScienceVS podcast. Come and say hello. We have no idea how YouTube works. We're podcasters, OG, podcasters. Still, you can listen to us for free on Spotify, YouTube, wherever you get your podcasts.
Starting point is 00:36:41 Follow us, like and subscribe. I don't know. I'm Wendy Zuckerman. Back to you next time. Hey, y'all. It's Kelly Clarkson with, Wayfair ever order furniture online and wonder what if like what if it doesn't hold up that sofa was four days old you should have ordered from Wayfair with Wayfair there's no what if just style you love and quality you can trust visit wayfair.cai fair every style every home

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