StarTalk Radio - Told You So! with Matt Kaplan

Episode Date: April 3, 2026

What happens when scientists are right and nobody wants to hear it? Neil deGrasse Tyson, Chuck Nice, and Gary O’Reilly explore the frustrating history of brilliant minds who were ignored, mocked, an...d punished for telling the truth with science writer Matt Kaplan. NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free here:  https://startalkmedia.com/show/told-you-so-with-matt-kaplan/ Thanks to our Patrons William D A, JK Smith, k c, Jim Worke, ufuk mevlevioglu, discount, Mark Snow, scott.hraha@gmail . con, Daren Covington, alex fricke, Alistair Gray, Jordi Estevez, Jeppe Blomgren, Kal McCloud, James Hale, Olivia Ruffe, Barbara, Tyler Dirkse, Bupkis Null, Tamajai Parrotte, Ebony Davis, Hailey Drake, Josh Whalen, SomethingWonderful, Ms.Yi, Luke Williams, L M, DP, Noah Golden, Courtney Minick, Megs, Jake, Terry Kirk, Joe G, Kip Kerley, Alec Walters, Alex Brown, Baxter, Austin Garcia, Sam W, Ladie Charette, Patrick Laverdière, juno brown, John Gary, Lucidious Flow, Leticia Farrar, Chu88, Fatima, Adrienne Bennett, David Labas, David Presnell, BLUE TIGER, Theresa Anoskey, Jahkenan Lloyd, Sambath Kumar Balasubramanian, Michelle Hester, Tatjana Gall, bandofspartans, Scarlet_Bukur92, LeopaldChaos, Mark Schwerin, Jack, Andrew, Edward Landry, Roland, Daniel Peter, Dan, Derek C, Erik Mardiste, Samuel Young, Keith McCredie, Dom, Ulq, Israel Soto, Q/Aurora Phoenix, JeanieZee, Terry Carr, Todd Bergmann, meteor guy, Patrick Congdon, Jeremiah Lewis, Janet Staples-Edwards, Eric Mensah, Chris Morales, Timothy Stanford, Dean Lasseter, Daniel Hays, Madhur Behl, Professor Grumbly Gut, Max Wolters, Jeremy Lewis, José Ikamba, Ian Ravenshaw Bland, Ron Spee, Brandon Smith, Richard Lord, Cody Avery Campbell (codesuniverse), Shawn Shields, M.R. Saar, and Nicole Elizabeth for supporting us this week. Subscribe to SiriusXM Podcasts+ to listen to new episodes of StarTalk Radio ad-free and a whole week early.Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Transcript
Discussion (0)
Starting point is 00:00:00 Coming up on special edition, I told you so. What'd you tell me now? Said some scientists that have known what no one else did. Yeah. After they were prosecuted, tortured, and killed. Yes. Coming right up. Welcome to StarTalk.
Starting point is 00:00:18 Your place in the universe where science and pop culture collide. StarTalk begins right now. This is StarTalk. Talk, special edition. When you hear special edition, it means Gary O'Reilly's in the house. Hey, Neil. Gary. Former soccer pro?
Starting point is 00:00:38 Allegedly. That's no one, we're not alleging that. There's a wiki page of you in a soccer outfit. Yes, I was. And we can see your hairy legs. Thank you. Chuck, a wicked have you, man. Yes, no wiki pages with my hairy legs,
Starting point is 00:00:51 unfortunately. Yeah, yeah. So, comedian, actor, and the Lord of Nice. There it is. All right, so Gary, what show did you put together today. Interesting one. If you think for centuries, science has at times aligned with and fought against religion,
Starting point is 00:01:08 who? Government, establishment, and even itself. But when the sticky up nail confronts historic theories and shouts change, it gets hammered. So who were these histories confrontationalists, the groundbreakers of science and medicine, the ones whom we owe so much? All right, with that said, let's bring on our guest name. Oh, okay. We've got with us reporting in from UC Davis, is that correct?
Starting point is 00:01:38 Matt Kaplan, Matt, welcome to Start Talk. Hey, thanks for having me, Neil. Yeah, yeah, I'm in Davis, California right now. There you go. All right. You're a science correspondent at The Economist. Love science correspondent. You know who doesn't have science correspondents anymore?
Starting point is 00:01:51 CNN. Right. They're always calling me up to do their job. And you're like, pay somebody, you cheap bastards. author a bunch of books. You know, my favorite title among these is the science of monsters. That's just, that's the funnest thing.
Starting point is 00:02:07 So that's about Jeffrey Epstein. Oh, so that's about Jeffrey Epstein. Oh, that's what I did. See what I did there? I see what you did there. I have heard that joke before, too. And your latest in 2026, told you so,
Starting point is 00:02:24 scientists who were ridiculed, exiled, and imprisoned. Yeah. for being right. St. Martin's Press. And that's, but see, that is the problem with scientists. They never go, told you. See that? See what I said?
Starting point is 00:02:42 I knew I was right. They never do that. And we need some of that from science right now. So a book such as that, Matt, it would be full of anecdotes and stories of cases throughout history. We don't do enough history on this program, I don't think. Well, now we're going to get a chance to Walden to Dunn. memory life. We'd get a taste of that. So, Matt, once you start us out, because there was a time
Starting point is 00:03:04 before which everything, anything organized, fell under religious institutions, including any efforts put forth by scientists. So can you comment on that fact? And when did that science sort of begin to tear free from those shackles? So you got to go back to the 15 and 1600s. And this is really a time where the church was pretty adamant that the earth was the center of the universe. And it was problematic because people invented the telescope. And folks started looking through the telescope and noticing the movements of things like comets and planets and saying, well, hang on a second. I've plotted where those things are going. And my calculations suggest that we are not the center.
Starting point is 00:03:58 There might be something else that is the center. It might be the sun. And unfortunately, the church didn't like that. That was heresy. And it could get you into an awful lot of trouble. And this is very much where Galileo Galilei found himself long, long ago. And in fact, it became a huge political issue in his time. And it really started out with his discourse on comets,
Starting point is 00:04:22 which was a battle with this other mathematics, a mathematician named Erezio Grasse, who was saying, look, I think the comets are going around the Earth, and Galileo was fairly certain they were not. And he wrote this piece called Discourse on Comets and eventually wrote a book called I'll Sagittory, which eviscerated Grassee not based upon and anything else other than his methods. And Sagittor is so important because Sagittor effectively established what we know today as the scientific method. I'm going to ask a question. I'm going to explore it and then come up with some conclusions based upon what I found. And no one had really done that before Galileo.
Starting point is 00:05:02 And it was a really big deal. So when do you think we started to establish, we being the obviously, I mean scientists of the day, began to establish that structure to enable them to think with rigor about the things that they were proposing? Well, it really started with Galileo. And then from that point forward, researchers started trying to answer. analyze the world around them. But different fields of science analyze things in different ways. Medicine was a catastrophe. So in medicine, during the Renaissance, researchers in Britain rediscovered the ways of Hippocrates. Now, Hippocrates was a Greek medic, or at least we think he was.
Starting point is 00:05:48 There's not a lot of evidence as to whether or not he actually existed. But the notion of the humors was rife during the Greek period. The humors was the sense that, oh, you're ill with a fever. You have bad blood or too much blood. Let's drain that bad blood out of you. Put some leeches on it. Oh, man.
Starting point is 00:06:07 But you know what's so crazy about the bleeding was that we mock folks who did it. But if you have a fever, if you have a fever and I attach 50 leeches to your abdomen, I guarantee you that fever will go down. You might die in the process because you're being drained of blood, but your temperature goes down. So they believed they were trading it. Yeah, yeah.
Starting point is 00:06:30 But there were also a lot of notions back during the ancient Greeks like, oh, you've got too much phlegm. So let's put you in a hot, steamy room and have you get the phlegm out. And actually, that's still used in medicine today. I was going to say that's actually a good thing. Well, hence the concept of being phlegmatic, I guess. Uh-huh. That's adjectival for certain conduct behavior. Yeah, so they were messing around in medicine with these different ideas, and it took years after Galileo before you started having scientists say, well, wait a minute, are Leach is actually helping?
Starting point is 00:07:05 There's one guy. He was in France, Pierre Charles Alexander Louis, quite the name, born shortly after the guillotine came down on Charles, on Louis the 16th. So this is a major time of change in France. and Louis was in this world where people were using leeches. They were holding their finger up and saying, well, you know, the winds aren't quite right. So I think we're going to have disease tomorrow. Or the stars in the sun aren't in alignment. We think disease is going to happen.
Starting point is 00:07:34 And that's, I mean, that was how science was done in medicine at that time. And Louis raised the question, are leeches actually helping? I don't think the leeches are actually doing anything. And so he said, oh, sacre blue, I will put on the leeches onto these people on day one of their pneumonia. My outrageous French accent, that's terrible. But he tried an experiment where he put leeches onto patients with pneumonia on day one to try to get the bad blood out of them. And with the other half of the population, he put leeches on day seven. Note, he did not create a control group that had no leeches.
Starting point is 00:08:14 leeches whatsoever because that would have been heresy. You weren't allowed to not treat people with leeches back then. You needed to apply the leeches. But he found that people who had the leeches on day one were far more likely to die than the people who had the leeches applied quite late. And to his mind, that made no sense. Because if you're trying to get rid of the bad blood, you should apply leeches early and that will help. But why were so many of them dying if they had the leeches applied early as opposed to late? And so that was the first hammer blow to old methodologies, and he did the extraordinary thing of actually recording his data sets. And he was not alone. There were folks in Hungary and Vienna and also in Massachusetts
Starting point is 00:08:54 who were starting to take notes and record the outcomes of patients. And that was really the application of Galileo's scientific method, but in medicine. And it had taken hundreds of years to get there. And these people who recorded these notes and said, hey, I don't think this is helping did not do terribly well. The rest of the populace did not like what they had to say. Many more people would have been alive had those methods and tools made it into medicine sooner. And they, in principle, could have. Is that correct? Is that one of the point you're making? So, okay, we could talk about bleeding for starters, right? So Pierre Alexander Louis was running this experiment and saying, look, I applied leeches on day one and it was not good. And he published those
Starting point is 00:09:41 results and he was forgotten. People did not take kindly to the notion that leeches weren't helping. And there was a sizable industry. Industry. Leach farms. You know. Oh my God. Leach. Leach. Oh, oh my God. Neal, they were importing 15 to 20,000 of the little suckers a year into Paris alone back in those days. Wow. So, I mean, there was an enormous demand for leeches. And being told, look, that's not helping didn't go very far. People weren't ready to hear it. I was going to say, Neil made the joke, the Leach Lobby,
Starting point is 00:10:17 but what you're talking about, I think we still see in many respects today, where we do something, it creates a sub-economy, and then things must be done to maintain the sub-economy, even though the reason it was created is no longer a problem.
Starting point is 00:10:35 Right, economic forces are the greatest. But that's one of the main mechanisms of pharmaceutical right now. creating this sub-industry, creating that lobby, but you can copy and paste out the subject matter, and it still has that dynamic. So we still haven't quite, pun-intended, cured ourselves of it. You know, I kind of take, I might not agree with that 100%.
Starting point is 00:10:57 I might not, only because of the rigors that are involved with bringing something to market. If you follow all the rules, then what you bring to market is, necessary. And what you might do is figure out ways to optimize your profits, but you're still optimizing profits on something that is necessary. That's why I don't believe when people say, oh, they've had a cure for cancer forever. And I'm like, nobody would ever hide that. It just doesn't make sense. But the rate of failure for new drugs is amazingly high. It's hidden in Area 51. Oh, Matt, you mentioned a couple of
Starting point is 00:11:41 of places around Europe, but there's that big example in Vienna, in the general hospital in the 1880s, where they had a 15% child bed fever, death rate, and it was still sort of practicing this Hippocratic method, and yet someone comes along and becomes that very different thinking outlier, but has to go against the machinery of the establishment. Oh, what is this story? please tell. So you are talking about Ignaz Semmelweis. Let us go back to the 1840s.
Starting point is 00:12:17 In early 1800s, Maria Teresa, who was the Empress of the Habsburg Empire, she had a whopping, I want to say it was 16 children, a lot. I mean, she had lots of kids. And she was uncommon amongst emperors in that she actually really cared about a lot of her subjects. and there was a massive problem back in the day was that women would get pregnant and they had no money to take care of the children so they would throw their children into the river
Starting point is 00:12:49 when they were born. And Maria Teresa thought this was terrible. They had established drop boxes. You know how if you're, you got to hand back that book at the library. No, you're kidding. But you're out of hours. So you got that drop box at the library
Starting point is 00:13:03 where you can put the book and they'll sort it the next day and you'd have to pay the late fees. They had a kid. Dropbox? They had kid drop boxes. Oh, well, now, by the way, I'm just going to say, Matt, that's not a really bad idea. As a man with three children, I'm just saying, how, what is the expiration date on Dropbox? Well, I think it was the size of the Dropbox that was really mattered. So it depends how large are your children? So Maria Teresa really cared about all of these women in her empire who were having babies and were desperately poor.
Starting point is 00:13:37 So she ordered the construction of a hospital in Vienna that was unheard of in terms of its size, absolutely enormous. And it was built to look after the urban poor, which is an incredible thing. But there were major issues. And this was known as preparal fever or childbed fever. And back in the day, upwards of 20% of the women in the hospital in Vienna would contract this disease. and if you got it, you died. We're talking about one in five women after delivering their baby
Starting point is 00:14:12 would develop these swollen blue and black splashes around their abdomen and their thighs and they would develop horrendous fevers, they'd become delirious, and I mean, it was so bad that within two to three days of developing the infection, even the gentle sheets on their bed laying across their abdomen was too much for them to bear
Starting point is 00:14:34 and they would die in front. frozen speechless terror from the pain about five days after childbirth. And their child would go to the grave with them. The children would die too. It was beyond horrendous. And no one really seemed to care. There was attention being paid to tuberculosis and smallpox. And that was because men could get it.
Starting point is 00:14:57 Per peril fever, men did not contract. And so there was very little attention paid. Ignaz Semmelweis, this Hungarian obstetrician. cared. He, and he was an extraordinary individual. He was so good at what he did. He had emigrated out of Hungary and was working in Vienna. Hungary was a vassal state to the Habsburgs. And so it was not unheard of for Hungarians to be working in Vienna. But Semmel Weiss watched this infection spread throughout the hospital, regularly losing patients to it, and was stunned by the indifference by the doctors at the hospital to the disease,
Starting point is 00:15:37 and he set his mind about trying to figure out what caused it and how to stop it spreading. He worked this out, and I can tell you about that, if you like. And when he revealed the mechanisms, he ultimately got shouted down and thrown out of his post. Wow. So really what you should have done was cure egos before he tried to cure the disease of childbed fever.
Starting point is 00:16:01 Well, that's certainly part of it. But there's so much more to it than that. Because we remember Galileo as an astronomer of incredible ability, but we forget what an exceptional diplomat Galileo was. He was charismatic beyond words. He made all the right friends. He moved in all the right circles. When he got into trouble, he was friends with very powerful people who saved his ass.
Starting point is 00:16:31 Simmel Weiss was from. a vassal state with no friends, and he had a habit of putting his foot in his mouth and crossing the wrong people in the Vienna circles. So even though he worked out solutions to prepare a fever, and they were extraordinary, he ultimately wasn't listened to, and it was because of a cacophony of causes. There were so many issues with some O' Weiss's interactions that he ultimately shot himself in the foot. I'm Joel Cherico, and I support StarTalk on Patriot. This is StarTalk with Neil deGrasse Tyson. We have to assume that this particular fever was cured,
Starting point is 00:17:30 and they found out how and why this was occurring. So does Semmel Weiss get the credit, or does he actually pop his clogs before this all comes to fruition? It's incredible. So Semmel Weiss followed the scientific method and made notes. He noticed, for example, there were two wards in this giant hospital. One was tended to by nurses,
Starting point is 00:17:52 one was tended to by doctors. And he kept a record of how many patients in each ward over the course of many months got preparall fever. And he noticed that the infection rate was hovering around 5 to 6% in the ward where nurses were present and about 21% in the ward where doctors were present. And he thought, well, wait a minute, I've been told that the sun, the moon, the stars,
Starting point is 00:18:16 the wind direction, control what diseases we get. But if that's true, we have the same sun, moon, and stars over the Vienna hospital right now. Why do we have such a different infection rate? So he tried feeding the patients in the doctor's ward, the food that was being delivered to the nurse's ward. No change. I mean, it was a legitimate question, right? I mean, what was causing it?
Starting point is 00:18:40 Then he tried burning all the sheets in the doctor's ward and replacing them with sheets from the nurse's ward. no dice. He went so far as to note that the priest in the temple that was adjacent to the hospital, he would walk through with incense and a bell every day when patients were dying. And since more patients were dying in the doctor's word, he thought, well, maybe the incense causes periol fever. So he had a word with the priest and said, could you not go in here for three or four months? I just want to take some notes. And the priest listened. None of this worked. Then one morning, Semmel Weiss was in the morgue, as doctors back in that day did.
Starting point is 00:19:19 Their habit every morning all across the world was to go down and to dissect the patients who had died the previous day to better understand why they might have died. It's a noble, a noble task, right? And when he finished, he washed up with soap and water and he smelled his hands. And he thought, my hands still smell of corpse. is there, because no one had any idea about bacteria back in the day, no clue. You know, is there an aura of death that is contaminating my hands from the corpse that then when I go and deliver a baby is infecting the birth canal? Is there something that I am doing?
Starting point is 00:20:02 And so he went to the local sewage treatment plant because, you know, raw human sewage smells pretty bad too. He noticed they were dumping chloride of lime into the sewer to try to make it stink less. And he asked the sewage treatment folks, hey, could I have some of that? Created a solution that was, you know, way more powerful than what you would ever put in your swimming pool, doused his hands in it and went, huh, no more death. The aura of death is gone. No more death. Never mind that the skin fell off his hands five days later because the solution was so strong. But, you know, I mean, he went, wow, the smell is gone. And then he started testing this. and he asked all the other doctors in the word to follow suit,
Starting point is 00:20:41 and remarkably they did. And the infection rate dropped, wait for it, from 21% to zero. How about that? So the doctors were infecting the children with death itself. Yes. They were bringing death to the birth canal. It kind of goes back to the scientific method of testing
Starting point is 00:21:02 and looking at the results and then testing and looking at the results. And did he know he was doing that? Or this is just something intuitively. He was like, okay, I'm just going to keep going until something happens. So he had had a mentor named Joseph Skoda, who was, honestly, for lack of better words, the best description is he was like the 1800s Vienna example of Sheldon Cooper. Socially inept, genius, knew exactly what he was talking about with numbers and was an outcast amongst the doctors at the Vienna hospital.
Starting point is 00:21:35 Semmel Weiss got on well with him and learned a lot from this fellow. And he learned how to make notes and keep records and start considering the concept of statistical significance. Although you don't need statistical significance when your rate of 21% goes to zero. That doesn't require p values or k-squared tests or anything. There's an old saying, this is not literally true, but it's figuratively true. If your results need statistics to prove it, you need a better experiment. Oh, that's funny. That's funny.
Starting point is 00:22:08 Design a better experiment. Right, right. Matt, what eventually is the final chapter for Ignace Semmelweis? Does he get lauded and adored for his work, or does he just unplug himself from this scenario? Well, unfortunately, it was far worse than that. It's amazing. He got all of the doctors in his facility
Starting point is 00:22:30 to adopt the chlorine washing mechanism and drop the rates of preparal fever. But Semmel Weiss had made a lot of missteps politically. Hungary rose up against Vienna because he didn't want to be a vassal state anymore. And Semmel Weiss had openly supported the rebels against the Austrians. And you have to remember, he was reporting to Austrian doctors. So that did not go well. Similarly, Semmel Weiss had, on multiple occasions, derided his supervisors who said,
Starting point is 00:23:04 said, yeah, we have these really bad cases of per peril fever because the sun, the moon, and the stars are out of alignment. And then someone wise, being really not very attentive to social interaction, said, yeah, but we have the same sun, the moon, and stars over both clinics. And the rate is really low in the nurse's clinic. And he would say this in front of the politicians funding the hospital. Right. So it did not win him a lot of friends. Ultimately, he was fired, even though he had dropped the rate to zero. he was exiled back to Hungary and eventually a group of his own peers put him into an insane asylum where he died. Wow.
Starting point is 00:23:42 And they lived happily ever after? There you go. So if we moved Matt forward a little bit to someone who is probably the polar opposite to Ignace Semmelweis, Louis Pester. Oh boy. Never met the man. But from having read parts of your book,
Starting point is 00:24:00 I believe it would be fair to say he did not lack self-confidence and has a poncho on for the deviousness and I think you called him brilliant tenacious, something else and then you finished with arsehole. Would you enlighten us to the Louis Pasteur story? That's kind of cool, that. Yeah, sure. So Semmel Weiss was so mild-mannered in his way
Starting point is 00:24:21 and ultimately, I think, really suffered because of it. Louis-Pestor was theatrical. he understood how to make a demonstration that would grab the limelight. Neil, there are some similarities there. He really knew how to talk, but he also, he had been, as a university student, he had a supervisor named Auguste Laurent, who had been very involved with the student rebellion that you see a lot in, reflected in Le Miserables at the barricades,
Starting point is 00:25:00 where the students rose up against the right-wing government to demand rights for the poor. And Auguste Laurent had taken their side, and Pestuor watched as his research supervisor lost funding from the government for being on the wrong side of politics. And it was a valuable lesson to Pasteur because he made sure that he never was on the wrong side of politics, ever. So he knew how to milk the French government.
Starting point is 00:25:26 from money, but he also knew how to tell a story. And he knew how to make sure that those stories never, ever had flaws in them so that people could raise doubt. So, for example, chicken cholera was a major problem for the poultry industry in Louis Pester's Day. It's not related to the cholera that kills people, but the end result is basically the same. Calora causes you to have such severe diarrhea that you die, and it causes chickens to have such severe diarrhea that they dehydrate and die. And Pasteur was in a race to create the vaccine or a treatment for that and then went on to try to defeat the disease anthrax that killed lots and lots of animals. Wait, wait, just if a chicken poops, how do you know it's diarrhea? Doesn't it all look like diarrhea?
Starting point is 00:26:12 It's the sound they make. More liquid, Neil, more liquid. You know, bird poop is lots more liquid. Just triple the liquid and you've got it and smell. apparently is bad. I've not ever seen chicken cholera in first person, nor do I really want to. Agreed. Anyway, back to anthrax. That sounds quite palatable on the back of that. Yeah, yeah, much better. So anthrax was affecting livestock all across Europe, and there was a desperate need to create a vaccine against it. And earlier on in his career, Pasteur knew about this veterinarian named Henry Toussaint.
Starting point is 00:26:52 And Henry Toussaint had said, you know, I think a way to create a vaccine against chicken cholera and then anthrax is to kill whatever the microbe is that is causing this. So he started messing with heat to heat treat samples and then inject them into animals. And the animals he noted would get ill but then not die and then become resistant to the disease afterwards. and Pasteur had been on the record saying, I think you are totally off. I think that killing the microbe isn't helpful. I think we need to weaken it. And so he was a big proponent of using oxygen to weaken bacteria so that you could create a vaccine up with a pathogen that was weak but not destroyed.
Starting point is 00:27:40 And he said, Henry Toussaint is totally wrong. In the end, there was tremendous pressure for Pasteur to be able to deliver an anthrax vaccine. and he did deliver in a very public way by injecting all of these sheep with anthrax, half of them had been vaccinated with Pasteur's vaccine, and none of the ones that had been vaccinated died. It was a very public demonstration of his work, and he proved that he had created a very successful vaccine, except when his journals and lab notebooks were opened 100 years later,
Starting point is 00:28:11 it was revealed that this was entirely fraud. He had stated that he had created the vaccine by exposing, the pathogen to oxygen? Not true. He had used Henry Toussaint's mechanism, the one that he had derided and discredited Toussaint for and lied about it. Desaunt died a pauper. Louis Pasteur went on to be celebrated as a national hero, but it was largely because of Pastor's treatment of him that that happened. And the same thing happened with rabies. Pierre Galteer, a veterinarian again, had developed a mechanism for creating a rabies vaccine. Louis Pasteur effectively stole that mechanism. created the vaccine, tested it on people, killed some people in the process, buried the evidence that he had killed people along with the bodies, and then lied about the mechanism and where he had got it from, effectively discrediting Galtier as well.
Starting point is 00:29:02 So he was pretty vicious and he was very successful as a scientist, but not in a nice way. Maybe he should have figured out a way to get light inside of the body. Oh, no. Or perhaps a little bit of bleach in a shot glass. Anyone else saw the bleach coming? I saw it coming. I saw it coming. I saw it.
Starting point is 00:29:31 Very effective. How is it that you have access to this information? And was it revealed earlier in the century? Yeah. So in 2003, it got published in a pretty academic book by, what was his name? I'm going to forget the guy's name, but he translated Pasteur's journals.
Starting point is 00:29:53 And what was really interesting, actually, in this piece, the author wrote, but you have to excuse this behavior of Pasteur because of the high-pressure environment of late 1800s French academic life. Like being in a high-pressure environment made it acceptable to so horrendously plagiarize and destroy people.
Starting point is 00:30:16 And so, you know, I'm not the one who translated the journals, but the journals haven't had a lot of discussions since they were translated. And I think, you know, it's important to point out that Louis Pasteur, yeah, he was phenomenally successful, but he was phenomenally successful. Yes, he was a genius, but he was also very effective at discrediting people who could get in his way. And he was also very good at telling positive stories without mentioning any places where he had faltered. And that was pivotal to him getting money. No one knows how gutthroat this business is. So he was an a hole. Yeah, he was a big giant.
Starting point is 00:30:55 But I've got to tell you, I mean, he was French. I mean, that's kind of okay. Don't you stop. You're just from the nation under the bus. I'm just saying, like if you're an A-hole and you're French, you get away with it. It's all right. You know, it's like part of their thing. You know what I mean?
Starting point is 00:31:10 It's like, hi, may I have some water? You may, you may not. What is your problem talking to me? Oh, come on. There were nice French people. They were nice French. I mean, Pierre Alexander Louis was a really good guy. And he ended up being a mentor to a very important American scientist.
Starting point is 00:31:29 Oliver Wendell Holmes, who had also tried to prepare a fever. I mean, so, I mean, there are good French doctors. Okay, so I love them. I love them to found one. Oh, damn, do faint praise. In your research, is there any reason why the sun, moon, and stars, particularly the stars, Neil, people thought was influencing health? I mean, this is a theme. I mean, influenza actually is influence of the stars.
Starting point is 00:32:00 This is something that persisted until, like, the early 1900s. What's going on there that people look up and say, okay? The fault, dear Brutus, lies not in your stars, but in ourselves. Look at that. Shakespeare. Well said. Yeah. I mean, did you uncover anything that would make, explain why that is?
Starting point is 00:32:21 Yeah. What are the urges? Yeah. Does it just an extension of astrology at that level? It is and it isn't. So think about chickenpox. Chickenpox has a season, right? It's spring.
Starting point is 00:32:33 Influenza has a season, right? It's the winter. Certain diseases, and it was more so back then before we vaccinated people so effectively, certain diseases had certain times. And you could measure that with the stars. You knew where you were, not just based upon whether the leaves were falling, but based upon what you could see with your telescope or even with the naked eye. And so there was this, I mean, it was, and also you have the power of narrative.
Starting point is 00:33:03 Once people believe something and you've had the story for a long time, it's very, very hard for them to stop believing in it. But there's another side to this. We were talking about the infrastructure underpinning pharmaceuticals and the medical community. There is also the fact that these doctors at the hospitals who were supervising Semmelweis
Starting point is 00:33:23 were very, very well established in the Austrian aristocracy. They had it good, and they had a steady paycheck, and there was no reason for them to change anything about the way they were working. They were going to continue getting what they wanted regardless.
Starting point is 00:33:41 and actually shaking things up, put them at risk of being identified as, wait minute, you were using this crazy method before, and now it's been proved wrong. Why were we paying you all this money? So you've got the power of long-established narrative with selfish self-interest, and then, of course, you also have the seasonality of these things, which made sense. So they ran into a lot of walls trying to overturn it, and lots and lots of people, beyond Semmelweis, fought the good fight and lost. So at the foundation here is science and science results,
Starting point is 00:34:15 I don't want to absolve Pasteur and others for their impropriety, but you have science intersecting culture and society. And so there are forces operating that are not purely scientific forces. Right. There's fame, there's money, there's influence, power, politics, all these things. They're all in there. These are contaminants. dominating forces on the purity of the science that should have none of that.
Starting point is 00:34:42 Right. And you want a whole book on it. So, Matt, if we fast forward, do you think there's an echo of that malaise still present in our scientific medical environments today? What of the malaise? An echo. An echo. And if it is an echo, when did the sound go away? When did we move away from all of that as part of the whole process?
Starting point is 00:35:08 and get down to just science. Unfortunately, we've really not abandoned it. And first of all, by the way, I want to emphasize, actually, you know, while Pasteur behaved very badly, Galileo behaved. He was excellent at diplomacy and negotiation in a manner that saved a lot of his ideas. And you don't have to backstab people
Starting point is 00:35:28 to take unpopular ideas to get them across in the end. Yeah, but in terms of the A-hole factor, you stuck with the ugly. You like that. You got to admit that when Galileo wrote the dialogue of the two chief world systems, you're arguing, there's Earth in the Center, as the Sun in the Center, and he has these two sort of, let's call them avatars, of one of them is Simplicio. And Simpliceo was arguing the points that are not scientifically valid.
Starting point is 00:35:58 And he put all of the arguments that the Pope made in the character. Simpliceo. By the way, that's brilliant. It's brilliant, but it's like... I'm sorry, but that is... Wait, wait, and he publishes it in Italian so that everybody can read it. It's not just Latin. Okay, so.
Starting point is 00:36:15 So that's kind of aho. So he's an ahold, but he's a smart ahold. See, because that's brilliant. I mean, honestly, that's like you want to convince some people of an argument. So you create two characters, dumbass and smart opinions. Right, but if the dumb ass, he said all the words that the Pope said, and the Pope is powerful. Well, but guess what?
Starting point is 00:36:35 It's like, didn't you look at the Pope and say, well, that's not you? That's dumb ass. You know? Okay. He's a smart. Yeah. A-ho. Unfortunately, the Pope was smart enough to work things out.
Starting point is 00:36:51 But Galileo was clever, and he dedicated that particular work, the dialogue of two systems, to Ferdinando de Medici, who was the Grand Duke of Tuscany. And if there was anyone powerful enough to interfere with the Inquisition, it was Ferdinando de Medici. And, you know, it's amazing. because Fernando DiMecchi had Galileo on the payroll. He was their chief scientist in Tuscany. And similarly, Galileo was bosom buddies with the ambassador to Rome for Tuscany. So when Galilei ultimately was called before the Inquisition, Ferdinandini D' Demetchi interfered
Starting point is 00:37:26 and ensured that Galileo was not tortured and ensured that Galileo was fed three meals a day made by the ambassador's wife. And when he was, when he was, when he was. When he was, eventually taken over to the Inquisition and living there. He was in a five-bedroom luxury apartment, a stone's throw from, you know, the Sistine Chapel. So Galileo was, we now know, was not tortured. And that's been, we've been aware of that for hundreds of years. But again, the power of narrative really sticks. It does make a difference. I like that narrative better. I have more respect for Galileo. That's like me getting arrested. They're like, all right, Chuck, we're going to give you five to ten. and you're going to live in this mansion
Starting point is 00:38:08 with the warden's wife. Wait, but I had not, that is a piece of history that had eluded me because I always was suspicious why it was that Gio donno Bruno is brought up in front of the Inquisition and he's burned at the stake.
Starting point is 00:38:25 Right. Whereas Galileo was born up in front of the Inquisition, not that many years later. Okay. And, well, he was on house arrest. On house arrest. Yeah, but he wasn't, like, put on the rack and tortured. Now, in the hood, we would have said that Galileo was a snitch.
Starting point is 00:38:42 Because Bruno went down and Galileo didn't. It's like, clearly you are an informant. No, in Galileo's defense, I think Bruno went down in advance of... Yes, he did, yeah. Yeah, I mean, it's important to note that the Inquisition wrote that Galileo was exposed to rigorous examination, and that was code for torture back then. Right. But Galileo was in his, what, Neil, like 68?
Starting point is 00:39:05 69 when he got brought in. And their method of torture was to put a, tie your hands behind your back and hoist you with your hands tied behind your back and then drop you abruptly. And Galileo would not have walked back to the Tuscan embassy on his own two feet at 69 if that had been done to him. Also, I mean, fun fact, the Inquisition was the epitome of organized evil. And they, have you ever, have you ever watched the princess bride? Yes.
Starting point is 00:39:35 Of course. You know, when they're torturing Wesley, there's like, you know, please tell us everything. This is for posterity. Well, that's what the Inquisition actually did. As people were tortured, they would write down every moan, every gasp, every scream. It was all noted for posterity. And it's not like the cleric who was doing this fell asleep, but the job when Galileo was brought in. It didn't happen.
Starting point is 00:39:57 And that's because Ferdinando Domenici, and by the way, the Domenici by that time, Domenici family by that time had already supplied two queens to. France and four popes. So these folks were really powerful, had ensured that Galileo did not end up tortured. So there was a lot of political disruption that occurred to protect Galileo and make sure that, you know, he didn't get burned at the stake. They're friends in high places. That's it.
Starting point is 00:40:22 I like Galileo even more now. He's a total gangster. If I sort of outline a story here, there's another level of suppression that even exists today where someone who's going to go on and win a Nobel Prize for saving millions of lives gets their belongings and all their work in a couple of bags in a hallway and told to leave the university. All right. Matt, would you do me a favor of fill in the blanks? Because this one blew me away when I read it. So this is Katikariko.
Starting point is 00:40:55 And Katikariko was working on Messenger RNA back in the 90s. and messenger RNA, she worked out, you could effectively program messenger RNA to produce any protein you're damn well pleased in the lab. And that had tremendous potential because if you could program messenger RNA and inject it into somebody and have it start producing proteins of a specific type,
Starting point is 00:41:19 that could be really useful for all kinds of medicines, particularly things like vaccines. Absolutely. But the problem was, as Katte was working, every time the mRNA got injected inside an animal, it would just fall apart. And she could demonstrate that there was potential here,
Starting point is 00:41:35 but she couldn't work out what the issue was. And when she applied for grants, the grants were rejected because the narrative that existed in the academic community was Messenger RNA isn't going anywhere. It's not worth your time. Even if the proposals were written well,
Starting point is 00:41:51 even if the experiments were well thought out, she got nowhere. As a result, because in academia today, you are only as good as the money you bring into the university. If you're not bringing in lots of resources from grants, the university takes a dim view and you slowly get pushed out. Katsi was first demoted for exploring messenger RNA and not getting enough grants. And then she was fired by the university because they felt she really was a waste of time.
Starting point is 00:42:22 She was threatened by the U.S. government with deportation back to Hungary. I mean, it's frustrating because ultimately we're very lucky that after 25 years of pain and suffering with all of this, she didn't just say, screw this, I'm going to go become a dental hygienist or a florist or something. You know, we're really lucky she stuck with it because she landed at this little pharma company called Bioentech. And Bioentech said, you know, we think this technique that you're working on has potential for an influenza vaccine. Can you develop it? and then the pandemic hit and they said okay screw that could you create a COVID vaccine with this and she did now it's important to mention that in her last years at the university she started partnering with Drew Weissman who was an immunologist and Weissman said I think what we're seeing
Starting point is 00:43:12 with the break apart of the mRNA is an immune reaction there's something about the messenger RNA that you're injecting in that is causing it to be targeted by the immune system in a way that the messenger RNA that naturally forms in your body is not attacked. There must be something, we have to do something to the messenger RNA, decorate it with the right proteins that make the immune system say, oh, you belong here. So it doesn't get mobbed. And Weissman was integral to identifying that key fact. And ultimately, Katikariko's work with Weissman paved the way for the COVID vaccine to be
Starting point is 00:43:48 created in record time and effectively pulled the world out of lockdown and she won the Nobel Prize. Well, she should have. But it's important to notice that Katikariko was so like Semmel Weiss. Semmel Weiss believed that he didn't need to publish. He didn't feel like he needed to stand on a soapbox like Pasteur and shout about his ideas. He didn't feel like he needed to manipulate the government or convince them to do anything. He just believed that doing good work would get him somewhere.
Starting point is 00:44:15 And it got him to the insane asylum, which wasn't good. Katikariko, I've interviewed her, and she's lovely. She's very fast. hard to follow. So she's a science journalist, not their dream. Let's put it that way. It's hard to interview. I think her grant proposals were also not perfect. And when you've got thousands of grant proposals going out to grant warning bodies and they're only going to grant one percent of the money, they're very quick to remove anything that doesn't look exactly right. And I think Katie fell into interesting idea, but not exactly right. And as a result, she wasn't getting funded.
Starting point is 00:44:54 And so Simul Wysenkati are actually kindred spirits. I almost called the book a tale of two Hungarians instead of, I told you so, scientists who are ridiculed exalted in prison for being right because I thought the parallel between the two of them was so strong. But then you also look at other people who are on to childbed fever, per peril fever, and trying to defeat it and other scientists who were right and got excoriated for it. And I realized, no, I don't want to make it just about these two Hungarians. It's a bigger story.
Starting point is 00:45:22 But we see it all the time in science today. And it's terrible. But you know what? Let me just for one second, I just got to, because I don't want us to veer into a place where right now there's this pervading sense amongst people who are wellness influencers and people who are anti-traditional science. and what I don't want people to think is that because these things happen, that we should eschew or throw away the stuff that got us to where we are right now. I think it's important to recognize that not only are these things at play in science, they're at play in pretty much everything.
Starting point is 00:46:10 So when you think about fine art, the artists that are very famous are the ones that have the best, rhetoric. They're not necessarily the most talented. They're the ones that can talk about their work in ways that are soaring and aspirational, or they have someone that does that for them. Politics, we don't elect the person who is best qualified. We elect the person that we like and who sounds good and who says the things that tickle our ears. So this is a human problem. It's It's not necessarily... Preach it. Lord Nice. Preach.
Starting point is 00:46:50 It's not necessarily a science problem. And I just want to say that because as we, you know, as we look at this, especially these two particular anecdotes, it can make it seem like the industry of, if you want to call science and industry, is stacked against people who don't have the right pitch or narrative. I think you're absolutely right. And I think it's really important to point out that. The issue with science, we should be having debate. It is incredibly important for science to challenge new ideas.
Starting point is 00:47:26 It is incredibly important for there to be debate. It is incredibly important for us to remain skeptical. M RNA was an out-there idea when Katikariko was developing it. The notion that there might be an aura of death around your hands after touching a corpse was an out-there idea back in the day. and it was important for people to say, are you sure about that? Can we test this? Those are important responses to have. What's not okay is to engage in character assassination and to imprison people or exile them because you don't like what you're hearing. That's not what science is about. And let's be
Starting point is 00:48:09 honest, science has got a man on the moon. Science has been able to resolve, I mean, transform HIV into a manageable condition from a death sentence. I mean, science is doing extraordinary. I mean, look at the number of people living in deserts because of desalienization plants, which are now all threatened by missiles, but never mind. The technology and the science has got us so far. So we don't want to abandon what we've got. But what we want to do is make sure that the science who are not the Galileo's,
Starting point is 00:48:40 who don't have the master diplomacy, the scientists who are not the Machiavellian fiends, like Pasteur, we want to make sure the people with the great ideas who don't have the skill set to take their ideas further still get the attention that they need. Because we've got some really big problems on this planet. And we need every good mind to be at our disposal to solve them. And just removing someone from the options because they don't speak loudly enough or are not diplomatic enough is an issue. And part of that comes down to scientists. We've got to work with scientists to better, have them better communicate what they're on about, but it also is about the public and it's about journalists.
Starting point is 00:49:23 Journalists have, science journalists in particular, have a tremendous responsibility to not just say, hey, look what was discovered, but to say, this scientist wondered this, they did this to find out, and look what they discovered as a result. You've got to tell the story, so the public understands. During the pandemic, science is. process was exposed in some pretty big ways. The debate that occurs in science, which is part of science, was exposed to a lot of people who didn't know it existed, and it left a lot of people doubting. And we've got to do a lot of catch-up here to make sure that everyone understands how
Starting point is 00:50:05 science works. The newspaper I've spent my entire adult life writing for has forever argued against the phrase laws and sausages, you never want to hear how they're made because they're both disgusting. The economist has argued that you got to talk about how laws are made to have a healthy democracy. And I think we have to do the same thing with science. We have to talk about how it's being run so that the public understands that debate and questioning and replication and then discovering when the replication reveals that an initial experiment was invalid, that that's okay. That's normal. That's how it's supposed to work. But most people don't understand that. Yeah.
Starting point is 00:50:42 So with Kati and her Nobel Prize, does she now break the glass ceiling? Is there any movement in the needle? After her phenomenon. Yes. So I don't think the glass ceiling is so much an issue about female making their way in science versus male, although there's certainly elements of that. And I don't think it's a matter of Hungarian versus American. I think the glass ceiling that really needs to be addressed here is it's an out there idea and look, she was right. And I think we are starting to see reform.
Starting point is 00:51:40 And I'm really excited about it because a number of organizations, several governments, including the Austrian government, which I think is hysterical, the Villum Foundation, Volkswagen are supporting programs that democratize funding in research. Let me expand on that for a moment. So right now you write your grant application, and it's considered by a grant committee, and the grant committee can probably award 30 labs funding, and they get thousands of applications. So the competition is fierce. And there's no doubt that when you get a thousand applications,
Starting point is 00:52:17 it's really easy for the grant awarding body to say, okay, these 650, they're not close. Remove. Let's just get those out of the pool. You're left now. with 350 grant applications, but let's say you can only give 50 of them funding. Rather than try to discern the difference
Starting point is 00:52:35 between good, great, and excellent, which is really hard to do, and all of our studies show that when you're trying as a grant body to differentiate between good, great, and excellent, you often are subtly affected by, oh, who published this? Was this?
Starting point is 00:52:52 Who wrote this? Is this from Harvard? Or is this from the University of Whitworth? water sand in South Africa? Or is this an application written with a vague accent in English that makes it obvious that the person is an English second language speaker? You're not even aware of these kinds of biases, but we know that when people are trying to separate from great and excellent, those biases start to impact. We also know that if the idea isn't all that well established, still well thought out, but not well established, that's a strike against you too, which makes
Starting point is 00:53:26 our research less creative, less innovative, and we continue to do more of the same rather than coming up with new ideas. So a way to solve that problem is to create a lottery. You take those 300 or 350 good, great, and excellent applications, and rather than try to select the top 50, say, you know what, we're putting these all into a fish bowl, and we're going to select them at random. Or select 25 that you think are all outstanding, and the remaining 25 will be selected from. the fishbowl. And the cost to this is you got to buy a fishbowl. You probably need to get some blindfolds and then you're going to pull them out at random. But there's very little cost to this and it would start to spread out the creativity in our science a fair bit more. I like that idea.
Starting point is 00:54:13 That's a great idea. Once you take out the bottom fraction and then you pluck the very top that everyone agrees with, if the rest could be so subtly filtered just, by institution or accent or name or whatever, then that's bad. That is bad. That's just bad. So you just make that random. I love that. I love that.
Starting point is 00:54:35 Has that been implemented? It is. So the Villam Foundation is doing it. The Austrian government is supporting it. I think British Medical is starting to consider it. There are a number of places that are rolling this out. And I think it has the potential to bring about more creativity and more tolerance for outside ideas. and researchers who might normally not get the attention of big grant awarding bodies.
Starting point is 00:55:01 And I don't want to say that this is my idea. Other people have had this idea, but it's starting to make its mark. And I think that's a good thing. You know, what else would be good is if governments just gave more money to science. How about that? I mean, that's a novel idea. How about the richest nation in the world, in the history of the world, just gives, you know, a percentage more to science.
Starting point is 00:55:24 It would change everything. Well, it actually would reduce fraud because when you're a scientist and you've got to pay your mortgage and you've got to put food on the table for your kids, ensuring that you continue to get the grant money is incredibly important. And if an experiment is not working out and you're off by just a tiny fraction of a percent, there is a powerful incentive to adjust the numbers in a manner that no one would ever detect. and that leads us to more Louis Pasteuric-like behavior that's becoming ever more common. And right now, you do that, and I mean, that's bad. Because if you and I were to steal $100,000 from a bank, we would go to jail. But if you lie about your results and someone reads those results and goes, oh, that's really interesting.
Starting point is 00:56:13 I want to run a follow-up experiment on that and applies for $100,000 grant to follow up, but they don't know that your work is fraudulent. they have now just taken $100,000, very likely from taxpayers to do work that is built on a house of cards that is going to collapse one day and it's a waste. And right now, if you engage in fraud, there's very little punishment other than being put on administrative leave from the university and being removed from your teaching circuit. If we were to establish some significant penalties for engaging in fraud and also establishing some better systems for detecting it, that would probably help too. But if you increase the pressure on researchers by cutting funding, it increases the pressure for them to then behave badly. If we ease the pressure, then I think fewer people are put into that sort of a situation.
Starting point is 00:57:05 Matt, before we wrap this up, I have this one thought that's stuck in my mind. We are experiencing in some places an anti-science stance. This history lesson that you've brought to us today, which was very enjoyable. Will it? illuminating. We don't enjoy stories of people lying and cheating and stealing. Then illuminating. Thank you. It is. This illuminating history lesson. Will it actually teach us anything? Are we going to rinse and repeat? Or will we be learning, do you think?
Starting point is 00:57:34 You know, the first step to resolving the anti-science stance that we've got, and I was just talking about laws and sausages and talking about how science needs to communicate what it's doing better, because there were a lot of miscommunications during the pandemic. I think talking about the problem, recognizing that we've got a problem, and then stating how we're going to solve that problem by having scientists communicate more clearly, getting the science journalists on task and educating the public as to how science is supposed to operate. We're supposed to argue. We're supposed to get things wrong. I think that will help a lot. I would add to this something that has yet to come up. You have picked from the history of science these examples that are. are most egregious, we agree. Some are even offensive when you lay it out for you. Yeah. Very French.
Starting point is 00:58:25 Very French. And so this is a, it's kind of, let's call it a knee-jerk reaction of the scientist to reject something that is novel, new, odd, or unusual. Let's just say that for the moment. Okay. And then you say, well, but was it a correct idea and we're losing it? Yes. However, that same skepticism over the novelty rejects 99 other ideas that flow into the house that are completely bat-shit crazy, that would never have a chance of being correct.
Starting point is 00:59:01 And you don't write a book about that. I don't want to shed light on that. Because that's not interesting to talk about the ideas that never would have worked. Okay? So I guess what I'm saying is I don't mind. if there's some people who want to sort of verify all these thousand ideas to find the one that was correct. But the operations of science and the methods and tools and the procedures are getting other science that does have a higher statistical likelihood of being correct. And that's why we have modern civilization the way it is today.
Starting point is 00:59:39 Okay, science is an active functioning enterprise. So I just, if I get your reaction to the idea that, that the conservatism of science is almost necessary, and yes, occasionally one goes out with the bathwater. So the conservative science is not just necessary, Neil. It's critical. It's healthy. We have got, it's like the immune system. It looks at things that it recognizes, and then when it sees it totally doesn't recognize, it attacks it and removes it. Very, very good example. Oh, I'm biologists. There you are. But there is a deal.
Starting point is 01:00:16 difference between being skeptical, challenging, and saying, I don't think that's right, I don't think that's right. And you may have to say that dozens and dozens of times. And that's, that is part of science, is saying, look, I've analyzed your methods, I've looked at your theory, and I disagree. And that's fine. That's what you have to do in science. Because as you point out, there's lots of bat shit crazy ideas out there. What we can't do is take the gloves off. It is important, especially if someone is persistent and continues to push the idea that they've found something that they think is worth talking about and you continue to disregard it. It is important to continue to hear them and say, nope, I've thought about it and you're wrong. A good example is
Starting point is 01:01:02 Alfred Vegner, who looked at the continents and said, hey, look, South America fits into Africa. Isn't that interesting? And look, the rocks on the coast of New England match the rocks that are on the coast of England. And maybe these two places were once together. I mean, he was derided as crazy. And ultimately, we worked out that plate tectonics was a thing. But my point is, it's important for us to fight back and say, I disagree, I disagree, I disagree. We can't engage in character assassination, even if we think it's bad shit crazy.
Starting point is 01:01:34 We just have to say, no, that doesn't fit, that doesn't work. And if they come back to us five years later with a different angle on why they think they're right, you got to read it and say, nope, still disagree, or wait a minute, why do I disagree? What's the reason that I disagree? So with your Wagner story, it was not a hundred years that that idea was rejected. It was just a few decades. And yes, there was some geologists behaving badly over that period, no doubt about it. But really, it was a matter of how strong is the evidence. if South America fits into Africa and other countries don't fit neatly, then this looks like it's a coincidence.
Starting point is 01:02:18 So I'm going to be skeptical of that. And I probably would have been one of those that said, this guy, you know, he's still at it. It was not until I think the discovery of the separation in the Mid-Atlantic Ridge when we were mapping the bottoms of the ocean primarily for submarine movement
Starting point is 01:02:35 in the Second World War. It's always war. Then, then, I don't think there were many people who were still holdouts back then. Because that was the... No. We saw the smoke.
Starting point is 01:02:44 That was the gun that fired that allowed us to say... Our geology... Brethren. So it was a matter of how much evidence is there for it. And there wasn't sufficient evidence to convince everybody.
Starting point is 01:02:58 Just because he was later shown to be right is not an argument against people rejecting his idea to be... Absolutely. Yeah, I think you guys are saying the same thing, though. Yeah.
Starting point is 01:03:08 Yeah. Yeah. Yeah. differently. But there's a difference between arguing again saying, look, I disagree with you, I disagree with you, and deriding him so aggressively that he was thrown out of the scientific community. Right. Okay. That's the behaving badly part. That's the behaving badly part. Yeah. Yeah. It's like, you know, there was a difference between Semmel Weiss making his, his remarks and being thrown in a lunatic asylum by his own peers. You know, I think, and same thing with Katikariko. It would have been okay for
Starting point is 01:03:36 scientists to continue to say, look, I don't think you're on to anything. I think. I think you're wrong. But threatening her with deportation, I think, we can all come together and say that's probably a step too far. Totally. So, but I think that goes back to when you talked about the random selection illustration that you gave. What it really does is put a blindfold on bias. And I think for Samoa's and for Katya, you're looking at unspoken biases that are at play here. Let's just be honest. That's really what it comes down. down to. And yeah, I think systemically, if you're able to remove that in any way,
Starting point is 01:04:15 science benefits as a whole. Yeah, of course, of course. And just, I'm going to give an exactual example from my own field. There's a guy named Fred Hoyle who was never a big bang guy. He was a big proponent of the steady state hypothesis of the universe. State theory, they called it. And he was rejecting the, notion that the universe had a beginning.
Starting point is 01:04:42 And he was a smart guy and he's done other great things. So it was hard to completely discount him, but the field just kept moving along. And he was wrong to his grave, thinking that we're all wrong and that he's right, but he was just wrong. He was just wrong. And so in this case, no, there was no character assassinations.
Starting point is 01:05:04 There was no, but he was a very visible opponent of a prevailing consensus. that he could not to his deathbed accept. Wow. Yeah. See, now that just sounds like a guy with a personal problem. Well, you can be emotionally invested in your own ideas. That's what I'm saying.
Starting point is 01:05:21 Don't we call that stubbornness? Stubberness? Yeah. Tick-headed is the word. So, Matt, we've got to land this plane. Let me send a question back to you. You've cited scientists behaving badly. You cited society behaving badly.
Starting point is 01:05:37 And these are all amazing. examples, and it's a brilliant compilation that you've created. What is the lesson to the public, given what we've been through with COVID, given the anti-science sentiment, given all that we see going around us? Because that's a different science climate than what I grew up in. What I grew up in, people saw science as our savior, as a, it would cure us. It would take us into the future. And I don't feel that anymore in our culture. So how do you turn what you've compiled here into the positive for the public to take a civilization ahead? Science still solves a lot of problems.
Starting point is 01:06:20 The thing we need to all be aware of is that science debates, it argues, it disproves, and that's normal. That's the way it has been for a very, very long time. It just was on show during COVID in a very public way. and I think a lot of people found that disquieting. We need to talk more about how science works. That's a responsibility that falls on scientists. It's a responsibility that falls on people like me, writing in the newspaper. And it also falls down to everyone out there to say, hang on, I don't understand how that works.
Starting point is 01:06:55 Can you explain that to me? And we need to start asking more questions and being more tolerant of the fact that sometimes science doesn't know. And we're still debating it and trying to figure it out. So, Matt, at my PhD defense, after I was grilled on the content of the thesis, the final question was, how would you tell a New York Times reporter about your work? Okay. That was part of it. Can you translate this?
Starting point is 01:07:22 Can you make this sensible to someone who's not an expert? And that doesn't happen enough in the sciences. There's no, we're not trained, nor is it valued, what is your capacity to communicate? This is not. So that's a big problem. That was in your list there, Matt. But also, I knew this while it was happening, but there was nothing I can do about it.
Starting point is 01:07:43 Because COVID was a novel, a novel... It was called the novel coronavirus. Exactly. Okay. So I was thinking to myself, what they should do is every week, whoever was the chosen person to report progress on this. You don't get a politician.
Starting point is 01:07:58 You get someone that's got some expertise, like Fauci, okay? He was the voice. So here's what should have happened. And I knew this at the time. Every week, what he should have done was get up there and said, this is what we know today. This is our recommendations based on the science research up to the moment. Check back in a week in case some of these results have changed based on more evidence that has arrived.
Starting point is 01:08:25 Then people would have seen a scientific process unfold in real time. But when I hear people say about anything, they'll say, even scientists don't agree on this, as though scientists sit back in our chairs with our legs up on the table, masters of everything we know. No, on the frontier that is so not the case. So do you agree with me that that would have been
Starting point is 01:08:50 a science lesson for people and there would have been less cynicism to derive from that whole episode? Not only do I agree, but I think that the culture of science doubt that we are faced with now would either be greatly diminished or non-existent if we had engaged in that behavior during the pandemic
Starting point is 01:09:10 because we shattered people's view of science being an answer machine. Right. That's a perfect sentence right there. And we revealed quite publicly how science works. There you go. And that's the problem. I think what also has to happen is the public has to understand that, oh, God, I'm going to get in trouble.
Starting point is 01:09:32 most of the people look at science like religion, religion has answers. Whether the answers are right or not does not make a difference. There's an answer. Right. And that's what comforts you in religion. There is an answer for it speaks to everything. That's not how science works. And I think that's the first thing that people need to realize.
Starting point is 01:09:55 And another example would have been, based on what we know of the virus, it may be transmitted over the surfaces of with fluids. So right now, you know, hose down your groceries when they come in. Well, that was the first couple of weeks. Flash down your grocery bags. Okay, so then the next way we say, we're finding, no, it's more airborne than liquid.
Starting point is 01:10:15 And so then we could just follow along. That would have been even fun. Right, exactly. Let's see what's going to happen next. What's happened next week. And please remember, it's the novel coronavirus. We don't know because it's new. And another one, another point of disappointment there was
Starting point is 01:10:29 you get vaccinated and no one told you at that, vaccination that you might still get COVID again and you have to be vaccinated again. No one said that, okay? And then when you get COVID again, of course, it was a milder case and the COVID mutated. But we didn't get a whole discussion of the mutation either. It was just, oh, now we're vaccinated. We'll get back to work. And then we get the omega and then the, you know.
Starting point is 01:10:50 And that's because we didn't find a way to put light inside of the body. So these are brilliant lessons here for you to share with us. from the history of time, the history of science and civilization. Lots of lessons there. Matt, it's been a delight to have you here. What's the book again? Oh my gosh.
Starting point is 01:11:13 I told yourself. Love it. Scientists who were ridiculed, exiled, and imprisoned for being right. Nice. Yep. Yes. Told yourself.
Starting point is 01:11:26 If you don't know, now you know. Okay. Matt Kaplan, And good luck on the tour for this book. Thanks for including us in your efforts to spread this very important insights into the conduct of us all. Yes. Thank you so much for having me.
Starting point is 01:11:44 It's been a joy. All right. Thank you. All right. Chuck, always good to have you. Always a pleasure. Yeah, Ray. Thank you, Neil.
Starting point is 01:11:50 All right. This has been StarTalk Special Edition. We're just talking about scientists and the public behaving badly. Who knew? All right, until next time, Neil deGrasse Tyson, keep looking up.

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