Tangle - The Israel–Hamas peace plan.
Episode Date: October 9, 2025On Wednesday, Israel and Hamas agreed to the first stage of President Donald Trump’s plan to end the war in Gaza. Precise details of the agreement are still being worked out, though the in...itial provisions took shape over night. Under the terms, within 24 hours, Israel will retreat to agreed-upon deployment lines — remaining in control of about half of Gaza; within 72 hours of Israel’s retreat, Hamas will release the remaining hostages. Israel will also return a multitude of imprisoned Palestinians, but it reportedly does not intend to release several prominent detainees, including Palestinian leader Marwan BarghoutiTangle LIVE tickets are available!We’re excited to announce that our third installment of Tangle Live will be held on October 24, 2025, at the Irvine Barclay Theatre in Irvine, California. If you’re in the area (or want to make the trip), we’d love to have you join Isaac and the team for a night of spirited discussion, live Q&A, and opportunities to meet the team in person. You can read more about the event and purchase tickets here.Ad-free podcasts are here!To listen to this podcast ad-free, and to enjoy our subscriber only premium content, go to ReadTangle.com to sign up!You can read today's podcast here, our “Under the Radar” story here and today’s “Have a nice day” story here.Take the survey: What is your reaction to the peace deal? Let us know.Disagree? That's okay. My opinion is just one of many. Write in and let us know why, and we'll consider publishing your feedback.You can subscribe to Tangle by clicking here or drop something in our tip jar by clicking here. Our Executive Editor and Founder is Isaac Saul. Our Executive Producer is Jon Lall.This podcast was written by: Isaac Saul and edited and engineered by Dewey Thomas. Music for the podcast was produced by Diet 75.Our newsletter is edited by Managing Editor Ari Weitzman, Senior Editor Will Kaback, Lindsey Knuth, Kendall White, Bailey Saul, and Audrey Moorehead. Hosted on Acast. See acast.com/privacy for more information.
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From executive producer Isaac Saul, this is Tangle.
Good morning, good afternoon and good evening, and welcome to the Tangle podcast, a place we get views from across the political spectrum, some independent thinking, and a little bit of my take.
I'm your host, Isaac Saul.
It is Thursday, October 9.
Back in the saddle today. Thank you, Ari, for stepping in yesterday. I was actually up in New York City at a media operator summit. Pretty cool experience. Lots of really interesting people doing awesome stuff in the media space up there. Just brilliant independent creators. Also had a genuinely moving, one of the most emotional moments I've had related to my work with Tangle. I got stopped by a woman up there who maybe is listening to this podcast. If she is, hi.
thank you, this made my day, who kind of did a double take on me and asked if I was Isaac from
Tangle and I said, yes, I was. And she immediately got emotional and kind of teary-eyed and told me that
the Tangle podcast had rescued her relationship with her father. She was, I took it, a more liberal,
maybe Democratic voter and her dad was a Trump supporter and they weren't really on speaking terms it
sounded like or their relationship was really strained. And because of the podcast,
They were kind of able to have a common ground to meet each other at.
And she got kind of emotional telling me, and I started getting choked up.
And it was a nice, it's a really nice reminder of like why we're here in some ways.
You know, I'm not, and I've never claimed to be trying to get everybody to agree or hold hands or, you know, it's not as wishy-washy as that.
But it is amazing and rewarding to just hear that.
you can present the news with a lot of viewpoint diversity and it can heal some divides.
So thank you for that story.
It really truly was the highlight of my day, my week, and it got me really motivated for some
of the work today.
To that end, I have a couple really fun announcements at the top of today's podcast.
First of all, next week, we're launching something new, which is not something we do often.
We're launching a new once-a-month newsletter and podcast called PressPass.
This is going to be a behind-the-scenes newsletter and podcast for paying members only.
And the idea is that we're going to release it once a month.
And the goal is to just be more transparent and engage with our audience.
And our ideas for the newsletter are going to be things like,
what are we working on behind the scenes at Tangle?
What challenges are we facing?
What problems do we have that we're trying to solve?
How's the business doing?
What's happening in the media space?
We're going to profile a staff member every week.
And then we're going to open the door for you guys to give us feedback directly with surveys
or callouts for help formulating ideas.
We're going to let you shape the future of this news organization, which we're really
pumped about. I'm really pumped about. I get so much clarity when I hear from our readers. And
I'm conscious of not just doing what readers want. We don't want to be audience captured, but it's
super exciting. So if that sounds interesting to you, if you want to pull the curtain back on who does
this thing, who's building this product you listen to every day, or what sorts of challenges we're
facing internally, what kinds of criticisms and feedback we're getting from our audience that
we're trying to address. This is going to be an awesome way to engage. And it's only going to come out
once a month, so it won't be adding a bunch of clutter to your inbox or your podcast feed.
But we do want it to be a premium product for our most loyal audience members, which are our
subscribers. So if you want it, you can go to retangle.com forward slash membership. Go to our website,
click membership, subscribe. You can subscribe to the newsletter to get it via email, or you can
subscribe to the podcast, get it via podcast, or you can subscribe to both to get it via both.
That's one. Number two, we have an awesome new YouTube video out. The YouTube channel is so
fun for me because John and Aden and Will and Ari and all the people who participate on
crafting YouTube scripts, they make these videos in the background. And sometimes I'm really
involved, but oftentimes I'm not. And then I just get to see the product come out as a consumer.
This is an awesome one.
John did a deep dive on data centers.
The giant, boring-looking window-less buildings
that are popping up everywhere
that you've probably noticed,
these huge facilities full of tons of, I don't know,
wires, computers, what are they doing?
Why are they here?
What purpose are they serving?
And how come it seems like more and more of them
are popping up all across the country?
This is a huge story,
especially with AI blowing up and demanding so much more of this.
So I was really interested in some of the stuff that they found in their research.
It's a six or seven minute video.
It's not long, but it's jam-packed with fascinating information.
The edits are awesome.
It's a great video.
You can go to our YouTube channel by looking up Tangle News on YouTube and checking the video out.
And of course, be sure to subscribe.
be sure to like it
you know just engage
with the video
and that'll help us in the algorithm
all right with that I'm going to send it over
to the man I'm mentioning John Lull
and he's going to break down today's main story
which is the peace deal in Gaza
which is a huge story
massive story
and a positive one
is a good story
and then I'll be back for my take
after you hear from the left and the right
and some views from the Middle East
Thanks, Isaac, for that incredibly kind and generous intro.
I love doing the podcast, but I also really, really love doing the YouTube videos.
It's fun to be part of a brilliant team with Aden and Will, helping with the research, scripting, editing.
It really is a team effort, and I'm just very thankful to have them.
And I hope you guys enjoy today's video on data centers.
we've got a lot more in the pipeline that we're excited to bring to you, so stay tuned.
In the meantime, here are your quick hits for today.
First up, federal authorities arrested a man suspected of starting the Palisades fire in Los Angeles in January,
which became the most destructive wildfire in Los Angeles history.
The suspect is charged with destruction of property by means of fire and faces a minimum of five years in federal prison.
Number two, a federal appeals court lifted a federal judge's order barring president,
Trump from calling up Oregon National Guard troops into federal service, but it kept in place
a second order prohibiting the president from deploying them in the state. The court will hear
arguments on Thursday about whether to pause the judge's order entirely. Number three, 500 National Guard
members arrived in Chicago for an initial 60-day deployment to support federal immigration officers.
Illinois and Chicago have jointly sued to stop the move, and Illinois Governor J.B. Pritzker called
the deployment an invasion. Separately, President, President,
President Trump said Pritzker and Chicago Mayor Brandon Johnson should be in jail for allegedly
failing to protect immigration officers. Number four, former Federal Bureau of Investigation Director
James Comey pleaded not guilty to charges he lied to Congress, and his attorney indicated that
he would seek to dismiss the case, calling it vindictive and selective prosecution.
And number five, the Internal Revenue Service furloughed approximately 34,000 workers
about half of its workforce due to the ongoing government shutdown.
We do begin with breaking news just a few seconds ago here.
President Trump has announced Israel and Hamas have signed off on what he is calling the first phase of his peace plan.
Trump making the announcement on his own social media site, writing in part, quote,
this means that all of the hostages will be released very soon.
And Israel will withdraw their troops to an agreed upon.
line as the first steps toward a strong, durable, and everlasting peace.
On Wednesday, Israel and Hamas agreed to the first stage of President Donald Trump's plan
to end the war in Gaza. Precise details of the agreement are still being worked out,
though the initial provisions took shape overnight. Under the terms, within 24 hours,
Israel will retreat to agreed upon deployment lines, remaining in control of about half of Gaza.
Within 72 hours of Israel's retreat, Hamas will release the remaining hostages.
Israel will also return a multitude of imprisoned Palestinians, but it reportedly does not intend to release
several prominent detainees, including Palestinian leader Marwan Barguti.
For context, on Monday, September 29th, President Trump shared a 20-point proposal that outlines
a series of actions to end the war between Israel and Hamas, including Hamas's release of 48 hostages
in exchange for nearly 2,000 Palestinian prisoners held by Israel, as well as a demilitarization
plan, rebuilding framework, and governance structure for Gaza after the war.
Prime Minister Netanyahu endorsed the plan, and Hamas reportedly expressed openness to its
key tenets. We covered the Trump administration's proposal, and you can check that out with a link
in today's episode description. White House Special Envoy Steve Whitkoff and advisor Jared Kushner
have led negotiations on behalf of the Trump administration, and they traveled to Egypt to
participate in the peace talks. Katari officials also played a key role as mediators between the sides.
In a post on truth social, President Trump said that all of the hostages taken by Hamas on October 7, 2023, would be released soon, and that Israel would withdraw its troops from Gaza.
This is a great day for the Arab and Muslim world, Israel, all surrounding nations, and the United States of America, and we thank the mediators from Qatar, Egypt, and Turkey, who worked with us to make this historic and unprecedented event happened, Trump wrote.
The president also suggested that he would travel to the Middle East this weekend.
Israeli Prime Minister Benjamin Netanyahu will convene his government on Thursday,
and they are widely expected to approve the deal.
Netanyahu welcomed the deal, calling it a great day for Israel.
Separately, Hamas announced it and accepted the deal,
but called on President Trump, the guarantor states of the agreement
and all Arab, Islamic, and international parties
to oblige the government of the occupation to fulfill all the agreement's commitments
and not allow it to evade or delay implementation of the accords.
Several unresolved questions remain, including the precise timeline for Israel's withdrawal from Gaza.
Furthermore, Hamas reportedly needs at least 10 days to locate bodies of dead hostages.
Egyptian officials also indicated that large issues such as the disarmament of Hamas
have not been worked out, framing the agreement as an initial step to allow negotiations to continue.
Today, we'll cover the latest on the potential peace deal with views from the left, right,
and Middle East writers, and then Isaac's take.
We'll be right back after this quick break.
All right. First up, let's start with what the left is saying.
Many on the left note that the war is not actually over, but see this agreement as a key step.
Others say Trump deserves credit if the deal holds.
In the Atlantic, Yaiyar Rosenberg wrote,
The Gaza War isn't over yet, but it could be soon.
The parties have only agreed to some form of exchange
in which Hamas will release its remaining hostages
in return for Palestinian prisoners,
including many serving life sentences in Israeli jails for terrorism.
Even if this release goes forward in the days ahead,
that will only end the Gaza hostage crisis,
not the Gaza war, Rosenberg said.
This first phase of Trump's peace plan
does not resolve any of the underlying issues
that continue to drive the conflict.
Among other outstanding concerns,
Hamas will still be standing,
still be armed,
and will not have been supplanted
by an alternative Palestinian regime.
Far-right members of Netanyahu's government
will still seek to vanquish the terror group
and potentially resettle parts of Gaza.
Ending the war in Gaza was always going to require
the president's personal investment.
Until recently, he seemed disinclined to give it.
Trump did not intervene as the first ceasefire he helped broker
in January fell apart,
but in recent weeks he seems to have latched on to the issue with renewed vigor, Rosenberg, wrote.
If he succeeds, that success will raise another question.
How far is he willing to go to achieve his promised peace in the Middle East?
The Gaza War is only an acute symptom of the region's underlying malaise.
In the New York Times, David E. Sanger said,
Trump is on the brink of a major diplomatic accomplishment.
For Mr. Trump, success in this venture is the ultimate test of his self-described goal
as a dealmaker and peacekeeper, and a pathway to the Nobel Peace Prize he so openly
coveted, Sanger wrote. Much could go wrong in the coming days, and in the Middle East, it often
does. The peace deal, Mr. Trump heralded on Truth Social on Wednesday evening, may look more
like another temporary pause in a war that started with Israel's founding in 1948 and has never
ended. But if Mr. Trump can hold this deal together, if Hamas gives up at least 20 living hostages
this weekend, and with them it's negotiating leverage, that would be in a cross.
extraordinary step toward the kind of peace plan Mr. Trump and his predecessor, Joseph
R. Biden Jr., have pressed to accomplish, Sanger said. Getting to the next stage, where Hamas
would have to give up its arms, and even harder, its claim to run Gaza, may prove even more
difficult than bringing the living and dead hostages home. Hamas may well balk at the next steps,
and so may Mr. Netanyahu.
All right, that is it for what the left is saying, which brings us to what the right is saying.
The right supports the deal, but many caution that Hamas could still derail it.
Others praised Trump for his unrelenting push for a peace agreement.
In hot air, Ed Morrissey asked, will Hamas comply and disarm?
The deal itself contains telling surprises.
Those also constitute good reasons for skepticism.
Now that the initial blush of joy over an apparent agreement to free the hostages,
the question remains, will Hamas comply?
Morrissey asked. The terms of Donald Trump's ultimatum contained poison pills that Hamas had refused
to accept over the last two years. This agreement does not require the full withdrawal of the IDF
from Gaza First or even at all in this phase. The requirement for Hamas to disarm remains,
although that too is pushed off for later phases of a broader peace agreement. Perhaps this is
nothing more than another spin on the dance floor to the Hamas Hokie-Poki. Hamas appears to
already be making demands for a shift in phasing, especially when it comes to positioning
the IDF, Morris, he said. This is the first step toward real progress for the hostages in
well over a year, but their freedom is not yet secured. Hamas has many ways to toss spanners
in the works and a track record for doing just that. If the polka music of the Hamas hokey-pokey
even plays for a bar or two, Trump had better be prepared to demonstrate a commitment to his
red lines. In the free press, Matthew Contenetti called the deal a triumph of coercive
diplomacy. The Gaza deal is a triumph of coercive diplomacy. By pairing support for Israel with
negotiations, President Trump leveraged IDF hard power to gain Hamas concessions. Just as he did in Iran,
Trump used the credible threat of military force to achieve his goal, Contonetti wrote.
Americans are often tempted to separate force from peace talks, thinking that one must proceed
the other. Trump doesn't make this mistake. For him, talk without action is meaningless.
Talk with action gets results. And demonstrations of
power are integral to the bargaining that culminates in a transaction.
The deal is also a victory for Prime Minister Netanyahu.
To date, his alliance with Trump has produced four historic achievements.
The Abraham Accords, the demolition of Iran's nuclear program, the deconstruction of Iran's
access of resistance, and the pending release of October 7th Captives, Continent, he said.
Over the past six months, the world has seen what's possible when America and Israel stand
together to confront the enemies of civilization. Let's not stop now.
All right, that is it for what writers from the left and the writer saying,
which brings us to what Middle East writers are saying.
Many writers from the Arab world say that the agreement does little to change
Palestinian's underlying struggle.
Some Israeli writers say Israel should still target Hamas's leaders even when the war in Gaza ends.
In the Middle East monitor, Adnan Himdan wrote,
We must keep marching for Palestine.
Every time the world hears a new development,
a roadmap, a framework, or now the first phase of Trump's agreement,
many are encouraged to believe that this could be the long-awaited turning point,
him done said. But for Palestinians, such announcements evoke not hope, but memory,
the memory of countless previous phases and initiatives that promised calm yet delivered
only more destruction. This is why we continue to march, because every so-called breakthrough
has left the fundamental injustice untouched, the same siege, the same dispossession,
the same impunity. There is still no permanent end to the siege, no accountability for those who have
committed war crimes, no guarantee that the displaced will ever return home. There is no recognition
of the right to live freely and with dignity. An agreement that leaves people starving,
homeless, or stateless is not a step toward peace. It is a continuation of the same crime
by different means, Hamadon wrote. To remain in the streets, therefore, is not a rejection of
negotiation. It is a demand that negotiations finally mean something real. Our presence is a reminder
that moral pressure must not fade simply because politicians have found new language to disguise
an old injustice. In the Jerusalem Post, Moshe Phillips said, Hamas must not win the peace with Israel.
Hamas leaders, responsible for the slaughter of some 1,200 people and the kidnapping of civilians,
are reportedly seeking safe haven in exile, most likely within the borders of its longtime host,
Qatar, Phillips wrote. The unspoken premise is that Hamas will remain part of the Palestinian Arab future,
that its leaders have some sort of right to flee Gaza and live to fight another day,
even though they are mass murderers.
Letting Hamas' leaders escape into exile would be more than a tactical error.
It would be a crime, allowing them to spin their survival as victory
and rally the next generation around their so-called resistance.
It would also send a disastrous message to terrorist groups worldwide.
Mass murder leads to international negotiations, global attention,
and eventually attainment of goals, Philip said.
has the right, nay, the obligation to finish what it started and dismantle Hamas completely,
just as the United States hunted down Osama bin Laden and decimated the ISIS leadership.
All right, let's head over to Isaac for his take.
It's genuinely surreal.
to read about a deal like this,
which looks like it might legitimately stick
moving forward
just as the two-year anniversary of the war passed.
I still remember waking up to messages
about October 7th and watching in horror
as the events that came after
upended so many lives in Gaza and Israel
and across the world.
The beginning of this war,
it feels so clear to me,
that memory, it feels like it was weeks ago
when it was two years ago.
And so much has happened in the last two years
in ways that I don't think any of us
could have fully grasped at the time.
To be here now, it feels unbelievable.
I am swimming in skepticism.
We had a multi-phase deal earlier this year
that never came to fruition.
Israel was still striking locations in Gaza over the weekend.
I'm just waiting for the news
that some agreed upon condition has been violated,
that some bad actor dynamites the agreement,
that some part of the progress was misreported.
But I am tentatively hopeful that we may finally have a light at the end of the tunnel.
As I said last week, the 20-point proposal was smart, it was novel,
and it included something for both sides.
Any workable deal always needed to include Israel withdrawing from Gaza
and the return of all the hostages Hamas is holding.
that the deal also managed to include removal of Hamas from power,
an opportunity for members of Hamas to disarm and seek amnesty,
a commitment from Israel not to annex Gaza,
and a return of aid distribution to the United Nations is all great news.
If the deal holds, it will quickly become the shining diplomatic achievement of the Trump administration.
Again, I have no illusions about where this might go.
Major questions remain.
The precise timeline for Israel's withdrawal is still murky,
The logistics of Hamas' disarmament have not been worked out.
But consider where we were just a few weeks ago.
Israel had bombed Qatar and tried to kill lead negotiators.
Qatar, a U.S. ally, was furious with Israel.
The U.S. was left mostly in the dark about the strike.
That could have evolved into the all-out regional war everyone has been fearing.
Flash forward to today, a deal is on the table that will immediately halt the fighting,
and the remaining hostages could be released as soon as Monday.
The first phase of the peace deal also requires Israel to withdraw its troops from Gaza
and for a rush of aid into the strip.
That Hamas has actually agreed to give up all the remaining hostages,
who, for the entirety of the war, have been its biggest leverage points,
is the strongest signal yet that the fighting might really be coming to an end.
After two years of sharing my analysis about the conflict
and given everything we have witnessed,
I'm finding it hard to be analytical here,
but I do feel like there is a moment
where it's important to take stock of the situation
and that moment is now.
This region has fundamentally changed since the war started.
Hamas has been all but destroyed
and now may be signing onto a deal
that forfeits their power in Gaza.
Numerous senior commanders from Hezbollah were killed,
and while it remains armed and active,
it is much weaker.
The nuclear threat from Iran has, at least in the short,
term been stifled. Its top scientists and some top generals were killed, and many of its proxies
have become less active in the region. For Israel, these will all be logged as victories. But the cost
has been immense. In Gaza, tens of thousands have been killed and much of the strip has been destroyed.
It will take years to fully rebuild and decades to mend the wounds of the war, if not longer.
Gazans who lived through the last two years will not forget what happened to them, and Israelis feel
as if their security has been shattered. Jews across the world, including me, have a newly
strained relationship with their ancestral homeland and its government. Israel's standing on the
global stage is diminished, with more external fury and internal frustration toward its government
than I've ever seen before. Its relationship with allies is more tenuous. Its leader,
Benjamin Netanyahu, is still fiercely opposed by many in Israel, and if the deal goes through,
he is primed to face a revolt from the right-wing faction that has held his coalition together.
So what will come next from Palestine, Israel, and the region?
The optimistic take about this devastating conflict has always been that it wrought so much destruction,
that it offered a reset, a real chance for new power to rise in Gaza
and for some kind of lasting peace deal that ends with Palestinian sovereignty and Israeli security.
We are, in my estimation, still pretty far off from that.
But with so few opportunities for optimism, this at least feels like a moment to celebrate a step in the right direction and an opportunity to imagine a future where the fighting, the violence, and the devastation can finally come to an end.
We'll be right back after this quick break.
All right, that is it for my take, which brings us to your questions answer.
This one's from Madison in Kansas City, Missouri.
Madison said, how far-reaching is the NSPM 7?
It is such broad language.
It seems like it can claim a lot of things is domestic terrorism.
I'm not seeing a lot of coverage about it.
Do NSPMs change how laws can be applied and forego rights granted by the Constitution?
Okay, first of all, we should define our terms.
N.SPMs are National Security Presidential Memoranda. They are what the Trump administration calls
its presidential directives on national security matters. Other presidential administrations have
issued similar directives, but they called them by different names. Barack Obama had
public policy directives. George W. Bush had national security presidential directives.
These presidential directives usually function as guidance for executive officials on national
security matters. Trump's NSPM one,
created the organizational structure for his administration's national security teams,
while NSPM 2 outlined the administration's plan foreign policy toward Iran.
They aren't binding directives like executive orders,
and they can't revoke laws or appropriate funding like acts of Congress.
They only affect the internal policy of the Trump administration.
Section 5 of NSPM 7 acknowledges this explicitly.
On its own, NSPM 7 isn't as extreme as it might seem.
policy it prescribes is a heightened focus on finding and disrupting possible domestic terrorism.
It doesn't create any new designations or prescribe any new punishments. Its broadest language comes
in Section 1, where after describing the recent spate of political violence targeting right-wing
figures, the memorandum outlines common threads animating this violent conduct. While these threads
conspicuously only include ideas that oppose the Trump administration's ideological goals,
the memorandum doesn't actually direct the federal government to declare these ideas domestic terrorism.
The alarming aspect of NSPM 7 is that it could shift priorities within organizations like the IRS or DOJ
to aggressively monitor and target organizations that the Trump administration deems worthy of surveillance.
It is, in effect, a formalization of the president's rhetoric,
and it could open up avenues for a group like the Joint Terrorism Task Force
to investigate left-wing groups under the guise of counter-terrorism.
Still, there are legal constraints to all the above,
and any actions downstream of the memo will certainly meet legal challenges.
What exactly those downstream actions could be is still, as of yet, unknown.
All right, that is it for your questions answered.
I'm going to send it back to John for the rest of the pod,
and I'll see you guys tomorrow with a very, very special edition coming out tomorrow.
So keep your ears out for that.
We'll see you then.
Have a good one.
Peace.
Thanks, Isaac.
Here's your under the radar story for today, folks.
In fiscal year 2025,
illegal crossings at the U.S.-Mexico border
fell to their lowest levels since 1970,
according to preliminary Department of Homeland Security data.
U.S. Border Patrol agents
recorded nearly 238,000 migrant apprehensions
in the fiscal year ending on September.
30th, and more than 60% of those apprehensions were recorded in the last full three months
of the Biden administration. The drop from recent years is significant. In 2022, Border Patrol
made 2.2 million apprehensions. The early data follows the Trump administration's heightened efforts
to restrict unauthorized entries, including its use of emergency powers to halt the U.S.
asylum system. CBS News has this story, and there's a link in today's episode description.
All right. Next up is our numbers section. It's been 733 days since Hamas's October 7th attack on Israel.
The length of time in hours of an initial ceasefire marking the start of the Gaza peace deal is 24, according to the terms of the agreement.
Hamas will have 72 hours to return all remaining hostages after the 24-hour ceasefire.
The winner of the Nobel Peace Prize will be announced in one day. The number of candidates for
2025's Nobel Peace Prize is 338. Out of those 338, 244 are individuals, and 94 are organizations.
All right, and last but not least, our Have a Nice Day Story. Some aspects of the human immune system
remain a mystery, even after centuries of research, but new findings shed light on a few of the
key outstanding questions. On Monday, three scientists, Mary E. Brunco, Fred Ramsdale, and Shimon
Sakaguchi were awarded the Nobel Prize in Physiology or Medicine for their work on
T cells, the white blood cells that fight infection in the body. Over multiple decades,
the scientists explored how the immune system knows to avoid attacking the body's own
healthy cells, identifying the FOXP3 gene, which is implicated in a rare human autoimmune
syndrome. The discoveries are already contributing to treating autoimmune diseases and cancer
with additional applications for lifesaving procedures like organ transplants. The New York Times
this story, and there's a link in today's episode
description.
All right, everybody, that is it for today's episode.
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Isaac Ari and Camille will be here for the suspension of the rules podcast,
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For the rest of the crew, this is John Law signing off.
Have a beautiful, wonderful, and absolutely fantastic weekend, y'all.
Peace.
Our executive editor and founder is me, Isaac Saul,
and our executive producer is John Wall.
Today's episode was edited and engineered by Dewey Thomas.
Our editorial staff is led by managing editor Ari Weitzman with senior editor Will Kayback
and associate editors Hunter Casperson, Audrey Moorhead, Bailey Saw, Lindsay Canuth, and Kendall White.
Music for the podcast was produced by Diet 75.
To learn more about Tangle and to sign up for a membership, please visit our website at reetangle.com.
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