TED Talks Daily - How nearly dying helped me discover my own cure (and many more) | David Fajgenbaum

Episode Date: September 8, 2025

Physician-scientist David Fajgenbaum was dying from a rare disease that didn't have a cure — until he discovered a lifesaving drug that wasn't originally intended for his condition. In an astonishing talk, he shares how his near-death experience led him to cofound the nonprofit Every Cure, which is using AI to uncover hidden treatments and save many other people's lives. (This ambitious idea is part of The Audacious Project, TED’s initiative to inspire and fund global change.)For a chance to give your own TED Talk, fill out the Idea Search Application: ted.com/ideasearch.Interested in learning more about upcoming TED events? Follow these links:TEDNext: ted.com/futureyouTEDSports: ted.com/sportsTEDAI Vienna: ted.com/ai-viennaTEDAI San Francisco: ted.com/ai-sf Hosted on Acast. See acast.com/privacy for more information.

Calgary, also known as the Blue Sky City. We get more sunny days than anywhere in the country, but more importantly, we're the Canadian capital of Blue Sky Thinking. This is where bold ideas meet big opportunity, where dreams become reality. Whether you're building your career or scaling your business, Calgary is where what if turns into what's next. It's possible here in Calgary, the Blue Sky City. Learn more at Calgary Economic Development.com.

Our homes are ready for any kind of cuts. We have bandages, sprays, gels to treat them. But we're quick to ignore gum bleeding and inflammation. We brush it off, literally. Use Colgate Periogard to significantly reduce gum bleeding and inflammation. It helps fight bacteria that can lead to early gum disease and improves gum health with daily use. So, the next time your gums feel sensitive, don't ignore it.

Help take care of it with Colgate Periogard. Healthy gums, confident smile. This episode is sponsored by Airbnb. A few years ago, I went to Vancouver for work, and I remember sneaking in a little time to wander Granville Island and grab something from the public market. It reminded me how much I love discovering new corners of Canada with Airbnb. Because let's be honest, when you're traveling with kids, sometimes you just need a kitchen at 6 a.m. That's one of the things I love about Airbnb. You actually get to settle in.

We can have breakfast together around a table, put the kids to bed, in real bedroom. and still stay up with my partner after. That's the kind of setup that makes trips in Canada so much more fun. You're not just getting a place to sleep, you're getting experiences that feel authentically yours, whether it's a lakeside cabin in Bruce Peninsula where you can literally roll out of bed and into a canoe or a cozy spot in Cape Breton

where you can make your morning coffee and watch the sunrise without anyone rushing you to check out. This summer, when you're planning those trips that matter, the ones where you want to actually connect with your loved ones, check out some of the most loved homes across Canada on Airbnb. You're listening to TED Talks Daily, where we bring you new ideas to spark your curiosity every day. I'm your host, Elise Hugh. Physician scientist David Faganbaum was dying from a disease that didn't have a cure

until he discovered a life-saving treatment in an unexpected place. Today, he's been in remission for over a decade. In this mind-blowing talk, David shares how this near-death experience led him to co-found every cure, a nonprofit that uses AI to accelerate the discovery of new uses and medications that are already approved by the American FDA. It offers hope for healing on an unprecedented scale. And stick around after the talk for a Q&A between David and Lateef Nasser, the co-host of Radio Lab and a guest curator at TED-12.

Hi, I'm David Faganbaum, and this is me in 2010 when all of my organs were shutting down, and I was dying for the first time. My doctors came in the room and told me, David, we've tried everything. There's nothing more we can do. But I was so sick, I didn't really know what my doctors meant until my family came in the room and started hugging me goodbye. and a priest read me my last rites. I was 25 years old, a former college quarterback, and a medical student who had dedicated my life to becoming a doctor after my mom died from cancer.

And yet here I was literally dying from a disease that I'd never even heard about during medical school called Castleman disease, where your immune system attacks and shuts down your vital organs for an unknown cause. There were no approved treatments and no cures. But in a last-ditch effort to save me, my doctors gave me a combination of seven chemotherapies that weren't meant for my disease.

Amazingly, they worked, I survived, I returned to medical school, and I got what I think might be the worst before and after picture of all time. But then I relapsed again and again. Five times in three years, I almost died for my disease. I'll never forget during my third relapse when I was laying in my hospital bed

with my girlfriend, Caitlin, and my family around me. My gown was, drenched in tears, not just because I was dying, but because all the things that I would miss out on, the family that I'd never had with Caitlin, the patients that I'd never treat, the cures that I'd never discover in memory of my mom. See, until then, I'd been waiting and hoping that some researcher somewhere would discover a treatment that could save my life. But in that moment, I realized that hope alone is not enough. If I wanted any chance of survival, I would need to turn my hope into action to try to find a treatment to save my life. There was just

one really big problem. I didn't have 15 years and a billion dollars to develop a new drug from scratch. The good news is that those seven chemotherapies that had saved my life, they weren't made for my disease. So I thought to myself, maybe there's another drug made for another disease that could also be repurposed for me. This concept of repurposing isn't new. You've probably all heard of Viagra before, right? Well, you may know that Viagra was repurposed from heart disease, to its well-known use. But as you know, it's also now utilized for a rare pediatric lung disease.

And thalidomide, which is known for causing horrible birth defects, is now utilized for leprosy and the cancer multiple myeloma. Now, repurposing works because though diseases like leprosy and myeloma may appear very different, they can actually share the same underlying problems or mechanisms in the body and can therefore be treated with the same drug. And amazingly, doctors can prescribe any FDA-approved drug, for any disease where they believe the benefit outweighs the risk,

through something called off-label prescribing. And off-label prescribing is actually very common. In fact, one and four prescriptions written every single day in the U.S. is off-labeled. So I began to study my own blood in the lab to try to find a repurposed drug for me. I discovered that a communication line of my immune system was turned into overdrive and that a decades-old transplant drug might be able to turn it off. It had never been used before for my disease, but I was out of options. so I began to test it on myself.

In the three years before I started Cyrillimus, I nearly died five times, but since starting it, I've been in remission for over 11 years. Oh, thank you. Thank you. During this remission, I married Caitlin, who's here with us today.

We had two amazing children. I wrote a book about my journey chasing my cure, which is being turned into a film, and I joined the faculty at the University of Pennsylvania to continue to chase cures for rare inflammatory diseases and cancers. And then in 2022, I co-founded every cure, a nonprofit organization that's on a mission to unlock the full potential of each and every drug to treat each and every disease that it possibly can.

Over these years, we've advanced 14 repurpose treatments for multiple diseases, saving thousands of lives like Kylo. who began her freshman year of nursing school after we repurposed a bone marrow cancer drug to save her life, which is now being studied in clinical trials. And Michael, who walked his son down the aisle on his wedding day, after we repurposed a melanoma drug to treat his rare cancer, which is now being used

all over the world for that rare cancer. With every one of these discoveries, all I can think about is how many more life-saving drugs are sitting at our local pharmacies that could be life-saving for patients with diseases today. Because see, us humans, we've developed 4,000 drugs for about 4,000 diseases. But there are over 14,000 diseases that don't have a single approved therapy. That means that one in 10 of us and our kids will develop a rare disease without any approved treatments. And many more of us will develop

diseases with limited treatment options. We know that many of these FDA-approved drugs could treat many more of these diseases, and for less than 1% of the cost of new drug development, and way faster. So why aren't we repurposing drugs? Well, the short answer is that it's just not profitable to pursue a new use for an existing medicine, especially for a rare disease and the 80% of drugs that are already generic. It just costs too much to do the clinical trials, and companies can't expect to make back the costs in sales. Instead, we focus on new drugs. for profitable diseases, and no one, not the NIH, not the FDA, not pharma, no one has taken responsibility for systematically unlocking these hidden cures.

Until now, we're utilizing artificial intelligence to scan across the world's knowledge of all 4,000 drugs and all 18,000 diseases to find the most promising opportunities to save and improve lives. You can think about it a bit like Netflix, which uses data on the actors, the directors, and the movies that you watch, and the interconnectedness between them to predict which movies you might like to watch in the future. Well, we do something similar,

but instead we use the world's knowledge of all approved drugs and all diseases and the connectedness between them to predict which drugs might be useful in new ways, much faster than any team of humans ever could. And then we use artificial intelligence to look across the millions of drug disease matches to identify the best opportunities to reduce suffering and have the greatest impact possible.

Then we take those specific, programs forward. We studied them in the laboratory, in clinical trials, and sometimes we go right to spotlighting them because the work has already been done to prove that they're effective. Now, when we first were dreaming about creating every cure, my co-founders, Grant Mitchell, Tracy Secorra, and I, we knew all of this was possible in theory, but we didn't really know how we were going to turn it into reality or how we were going to fund it. Clinical trials are not cheap. But then I got an email actually from a member of the TED TEDx. community, telling me about something called the

Audacious Project, which selects 10 nonprofits every year solving the world's biggest challenges. And just knowing that audacious existed and knowing that this community here was supporting this kind of work, it gave us the courage to really take this leap and to start this organization.

We got started and then we applied for funding and we were so hopeful we would get it and then we weren't selected. But then we applied again and just a few months ago we received this It's really transformative funding. Thank you all so much, really.

Thank you. Between this funding from the Audacious Project and also from a federal agency in the U.S. called ArbaH, we are building an AI-powered engine to repurpose 15 to 25 treatments by 2030 and with additional funding to be able to repurpose dozens and even hundreds more treatments. Now, we've only been running our full pipeline for a few months,

but we're already helping patients. The very first time we used a high-scoring drug from our algorithm was for a patient with Castleman disease, the disease that I have, but unfortunately the treatments we discovered for me weren't working for this patient. He was getting ready to say goodbye to his wife and his daughter because he was getting ready to be transferred to hospice care.

We recommended this number one drug from our platform, and amazingly it saved his life. He's been in remission now for over two years. Thank you. Thank you. Now, this is an example where we discovered a repurpose treatment, but sometimes we actually uncover matches that already exist. They're just not being utilized.

For example, one day I was reviewing through the results of our platform, and I came across Lucavoren, this cheap vitamin derivative, where there was data to suggest that it could help to improve speech in a subgroup of patients who have antibodies against the folate receptor, so therefore they don't get folate into their brain. I was so amazed to learn about the work being done by Richard Fry. He had done the first of three randomized controlled trials that showed a benefit for this medicine in this subgroup of patients.

And I learned about Mason, who was nonverbal for three years, and within three days of starting Luke of Warren, began to say his first words. And then, yes, it's incredible. And then Ryan was basically nonverbal for five years, and had never shared a complete thought or feeling with his parents, and was told by doctors that he probably would never share a feeling with them. Within two weeks of starting Luke of Warren,

he turned to his dad when he was leaving for work and said, Daddy, I love you. It's just incredible. It's just incredible. What's also incredible is that there's a blood test that can help to identify kids like Mason and Ryan that is available to help to find these patients, and it's still barely being utilized.

This is why we started every cure to unlock these hidden treatments and make sure they reach every patient they can possibly benefit. Like we did for Joseph, who was dying from Poem syndrome, which is a rare cancer, and on his 30th birthday, was saying goodbye to his girlfriend, Tara,

because his doctor had tried everything that he thought was possible. We recommended three drugs that are commonly used for multiple myeloma, which is similar to Poem's syndrome, in a lastage effort to save him. And amazingly, they worked. Instead of planning Joseph's funeral service,

Joseph and Tara planning their wedding day, and Joseph's here with us today from Seattle. Joseph, I'm so glad you're here. How many of us have sat with someone we loved, like Caitlin did, and like Tara did, and like Mason's parents did, and heard the words, we've tried everything. There's nothing more we can do.

What if we haven't tried everything? What if there's a solution out there for them and thousands, maybe even millions more with their disease. And what if we all came together to find these solutions? Because we can't do it alone, and we need your help. Please join us to unlock every cure so that no patient suffers when there's a lifesaving cure sitting on the pharmacy shelf.

And instead of hearing, we've tried everything, they can hear, we have something. Thank you all so, so much. David, this feels miraculous. Like, you're telling me that they're dying people waiting for a drug to be discovered, but actually they can just go down to their corner pharmacy, and there might be a cure for them at an affordable price? That's right.

It's like too good to be true. That's right. Well, it is, except for the fact that it's just not profitable to do this. So that's why it exists. These opportunities that are there, we can help a lot of people, but in the current system, there's just no incentives to do it. One of the other interesting things to me, I studied the history of medicine,

and what's so interesting is, for a lot of history, medicines were cure-alls, right? Like the 19th century patent medicine that was like for your indigestion and your infertility and your da-da-da-da-da. And then so much of modern medicine was evidence-based targeted, like laser-focused therapies, and it's almost like you're saying,

no, no, no, no, no. We need to broaden it out again. That's exactly right. And in fact, companies will oftentimes consider 15, 20, or even 30 diseases for a given drug, but they have to pick the one or two to focus on. And oftentimes those dozens of opportunities just sort of get lost. And so we're trying to uncover them, try to find, you know, what's really been falling through the cracks.

What can ordinary people do to help? Well, the first thing is that we really want you guys to all be a part of this solution. So if you've ever received a drug that was repercussions, was repurposed for your disease, receive a drug off label, tell us about it. Go to everycure.org slash ideas. And we also, as I mentioned earlier, these trials are very expensive. So donating to us at everycuret.org slash donate. And of course, part of this is running campaigns to get the word out about these treatments.

So if you see us sharing about treatments that can help patients, please, please help to amplify that. Thank you so much, David Faganbaum. That was David Faganbaum at TED 2025. This ambitious idea is part of the Audacious Project. Ted's initiative to inspire and fund global change. Learn more at audaciousproject.org. If you're curious about Ted's curation, find out more at TED.com slash curation guidelines.

And that's it for today. Ted Talks Daily is part of the TED Audio Collective. This talk was fact-checked by the TED Research Team and produced and edited by our team, Martha Estefanos, Oliver Friedman, Brian Green, Lucy Little, and Tonzica, Sung Marnivong. This episode was mixed by Christopher Faisi Bogan. Additional support from Emma Tobner and Daniela Balareso. I'm Elise Hugh. I'll be back tomorrow with a fresh idea for your feed.

Thanks for listening. This episode is sponsored by Airbnb. A few years ago, I went to Vancouver for work, and I remember sneaking in a little time. to wander Granville Island and grab something from the public market. It reminded me how much I love discovering new corners of Canada with Airbnb. Because let's be honest, when you're traveling with kids, sometimes you just need a kitchen at 6 a.m. That's one of the things I love about Airbnb. You actually get to settle in. We can have breakfast together around a table, put the kids to bed in real bedrooms, and still stay up with my partner after. That's the kind of setup that

makes trips in Canada so much more fun. You're not just getting a place to sleep. you're getting experiences that feel authentically yours, whether it's a lakeside cabin in Bruce Peninsula where you can literally roll out of bed and into a canoe or a cozy spot in Cape Breton where you can make your morning coffee and watch the sunrise without anyone rushing you to check out. This summer, when you're planning those trips that matter,

the ones where you want to actually connect with your loved ones, check out some of the most loved homes across Canada on Airbnb. Time to check on the skies. It's another sunny day in Calgary. Forecast calls for high levels of economic activity. Late afternoon, we've got a burst of potential in a place-ranked North America's most livable city. Tomorrow, blue-sky thinking in the blue-sky city should hold steady, and the outlook remains optimistic throughout the week.

So come grab your dreams and enjoy watching them take hold. It's possible in Calgary, the Blue Sky City. For the full economic forecast, visit calgary economic development.com. Our homes are ready for any kind of cut. We have bandages, sprays, gels to treat them. But we're quick to ignore gum bleeding and inflammation. We brush it off, literally. Use Colgate Periogard to significantly reduce gum bleeding and inflammation.

It helps fight bacteria that can lead to early gum disease and improves gum health with daily use. So, the next time your gums feel sensitive, don't ignore it. Help take care of it with Colgate periogard. Healthy gums, confident smile.