The a16z Show - Finding a Single Source of AI Truth With Marty Chavez From Sixth Street
Episode Date: May 22, 2024a16z General Partner David Haber talks with Marty Chavez, vice chairman and partner at Sixth Street Partners, about the foundational role he’s had in merging technology and finance throughout his ca...reer, and the magical promises and regulatory pitfalls of AI.This episode is taken from “In the Vault”, a new audio podcast series by the a16z Fintech team. Each episode features the most influential figures in financial services to explore key trends impacting the industry and the pressing innovations that will shape our future. Resources: Listen to more of In the Vault: https://a16z.com/podcasts/a16z-liveFind Marty on X: https://twitter.com/rmartinchavezFind David on X: https://twitter.com/dhaber Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Transcript
Discussion (0)
I cannot believe he said this to me in 1981, but he said the future of the life sciences is computational.
The through arc is my entire career.
I've been building digital twins of some financial or scientific or industrial reality.
We looked at that and thought, wow, we better do something about this very large unhedged position.
That was the history of Dodd-Frank.
Like, we don't really know what went wrong in the financial crisis.
So let's just go regulate everything.
And I think 99% of it was red tape that did not make the world a better place.
This was one of the many early nuclear winters of AI.
I walked right into it.
Hello, everyone.
Welcome back to the A16s week podcast.
This is your host, Steph Smith.
Now, today we have a very special episode from a new series called In the Vault.
This series features some of the most influential.
influential voices across the finance ecosystem, including, of course, our guest today, Marty Chappitz.
Marty is now the partner and vice chairman of Sixth Street Partners. However, he's long had a knack for
spotting how a healthy serving of technology can disrupt other industries. From his PhD of applied
artificial intelligence to medicine, to being one of the founding engineers of the team that created
SecDB. That's the software that perhaps couldn't predict the global financial crisis, but famously
helped Goldman survive it.
So today, Marty sits down with A16Z general partner David Haber, and they talk about a lot more, including where the puck is moving in this new wave of technology and the role of regulators and lawmakers within that.
And of course, if you like this episode, don't forget to check out our new series in The Vault.
You can find that on our A16Z live feed, which will also include in the show notes.
There you can find other episodes with Global Payment CEO Jeff Sloan and Marco Argenti, the CIO of Goldman Sachs.
All right, David, take it.
away. Hello and welcome to In the Vault, A16Z's FinTech podcast series where we sit down with the
most influential leaders in financial services. In these conversations, we offer behind-the-scenes
view of how these leaders guide and manage some of the country's most consequential companies.
We also dive into the key trends impacting the industry and, of course, discuss how AI will
shape the future. Today, we're excited to have Marty Chavez on the show.
Marty is currently a partner and vice chairman of Sixth Street Partners, a global investment firm
with more than $75 billion in assets under management.
Prior to 6th Street, Marty spent over two decades at Goldman Sachs,
where he held a variety of senior roles,
including Chief Information Officer, Chief Financial Officer,
head of global markets,
and served as a senior partner on the firm's management committee.
He was also one of the founding engineers
behind the legendary software system, SecDB,
which many believe helped Goldman avoid the worst of the global financial crisis.
In our conversation,
Marty talks through the evolution of technology
in financial services
and the potential impact of artificial intelligence.
Let's get started.
As a reminder, the content here is for informational purposes only.
It should not be taken as legal, business, tax, or investment advice,
or be used to evaluate any investment or security,
and is not directed at any investors or potential investors in any A66Z fund.
For more details, please see A66c.com slash disclosures.
Awesome. Marty, thank you so much for being here.
We really appreciate it.
David, it's pleasure.
I've been looking forward to this.
Marty, you've had a fascinating career. Obviously, you played a really pivotal role in turning the Wall Street trading business into a software business, especially during your time at Goldman Sachs and also now at 6th Street. But you also serve on the boards of the Broad Institute, on Stanford Medicine, and a bunch of amazing companies. Maybe walk us through your career arc, and what is sort of the through line in those experiences?
Well, let me talk about a few of the things I did, and then the arc will become apparent. So I grew up in Albuquerque, New Mexico.
I had a moment really liked the movie The Graduate when I was about 10,
and my father put his arm around my shoulder and said,
Martín, computers are the future.
And you will be really good at computers.
And this was 1974.
And it was maybe not obvious to everybody.
It was obvious to my father.
He was a technical illustrator at one of the national laboratories.
and there was this huge computer that they had just bought that his team used to draw these beautiful
blueprints for the weapons in the nuclear arsenal.
And they really had the latest and greatest equipment when it was very clunky and very expensive
and my dad knew where it was going.
So in New Mexico, you don't have a ton of choices, especially at that time, is basically
tourism and the military industrial complex.
So I went for the military industrial complex, and my very first summer job when I was 16 was at the Air Force Weapons Lab in Albuquerque.
The government had decided that blowing up bombs in the Nevada desert was really problematic in a lot of ways.
And some scientists had this idea crazy at the time that we could simulate the explosion of bombs rather than actually detonating them.
and they had one of the early Cray 1 super computers, and so for a little computer geek kid, this was an amazing opportunity.
And my very first job was working on these big Fortran programs that would use Monte Carlo simulation.
So I got an early baptism in that technique.
And you would simulate individual competent electrons being scattered out of a neutron bomb explosion
and then calculate the electro-magnetic pulse that arose from all that scattering.
And my job was to convert this program from MKS units to electron rest mass units.
And so that certainly seemed more interesting to me than jobs in the tourism business.
And so I did that.
And then the next big moment was I went to Harvard, I was a kid, and I took sophomore standing.
And did you, by any chance, did you do sophomore standing?
I didn't do soft for standing.
I also went to Harvard. I think we also studied about chemistry.
Yeah. We set it out. So yeah.
So you have to declare a major concentration right away if you take sophomore standing.
And I didn't know that. And I didn't know what major I was going to declare.
It was going to be some kind of science for sure. And I went to the Science Center.
And the science professors were recruiting for their departments.
And I remember Steve Harrison sitting opposite a table saying, what are you?
And it was a little bit like a Hogwarts question, I suppose.
And I said, I'm a computer scientist.
And I cannot believe he said this to me in 1981, but he said the future of the life sciences is computational.
And that is amazing, right?
And so profound and so prescient.
And I thought, wow, this must be true.
And he said, we'll construct a biochem major just for you.
And we'll emphasize simulation.
emphasize building digital twins of living systems. And so I walked right into his lab, which was
doing some of the early work on x-ray crystallography of protein capsids and working to set up the
protein data bank. And who knew that, well, even back then, he wanted to solve the protein folding
problem. And I remember he said it might take 50 years. It might take 100 years. And we might
never figure it out. And that's obviously really important because that protein data bank was the
raw data for alpha fold, which later came in and solved the problem.
And so the through arc is my entire career.
I've been building digital twins of some financial or scientific or industrial reality.
And the amazing thing about a digital twin is you can do all kinds of experiments and you
can ask all kinds of questions that would be dangerous or impossible to ask or perform
in reality.
And then you can change your actions based on the answers to those.
questions. And so for Wall Street, if you've got a high fidelity model of your trading business,
which was something that I, with many other people, worked on as part of a huge team that made
SECDB happen, then you could take that model and you could ask all kinds of counterfactual
or what-if questions. And as the CEO of Golden Sachs, Lloyd Blankfine, who really commissioned and
sponsored this work for decades, would say, we are not predicting.
the future, we are excellent predictors of the present. And I've been doing some variation of that
ever since. That's fascinating. I don't want to spend more time kind of digging into SECDB because that was also
a pressure decision, obviously during the financial crisis. But maybe just go going back. I know you ended up
doing some graduate work in healthcare and in AI. How did you go from that into Wall Street? Maybe
walk us through that transition because it's not probably obvious maybe for most. And then, you know,
would love to kind of dig into your time at Goldman and the founder, etc.
I got so excited about these problems of building digital twins of biology
that it seemed obvious to me that continuing that in grad school was the right thing to do.
I actually wanted to go out and start making money and I really owe it to my mom
who convinced me that if I didn't get a PhD then I wasn't going to do it.
I'm sure she was right about that.
And so I applied to Stanford.
that was my dream school.
And so what happened is I was working on this program,
artificial intelligence in medicine,
that had originated at Stanford under Ted Shortlift,
who was extremely well known even back then
for building one of the first expert systems
to diagnose blood bacterial infections.
And so I joined this program,
and we and a bunch of my colleagues in the program,
program, took his work and thought, can we put this work, this expert system inference,
in a formal Bayesian probabilistic framework?
And the answers you can, but the downside is it's computationally intractable.
So my PhD was finding fast, randomized approximations to get provably nearly correct answers
in a shorter period of time.
So this was amazing as a project to work on, but we realized pretty early on that the
computers were way too slow to get anywhere close to the kinds of problems we wanted to solve.
The actual problem of diagnosis in general internal medicine is you've got about a thousand disease
categories and about 10,000 various clinical findings, laboratory findings or manifestations or
symptoms. And the joint probability distribution that you have to calculate is therefore on the
order of 1,000 to the 10,000. And this is a big problem. And we made some inroads, but it was
it's clear that the computers were just not fast enough.
And we were all despondent, and this was one of the many early nuclear winters of AI.
I walked right into it.
I remember I stopped saying artificial intelligence.
I was embarrassed, right?
Like, this is not anything like artificial intelligence.
And a bunch of us were casting around looking for other things to do.
And I didn't feel too special as I got a letter in my box at the department.
And the letter was from a headhunter that Goldman Sachs had engaged.
And I remember the letter.
I probably have it somewhere.
It said, I've been asked to make a list of entrepreneurs in Silicon Valley with PhDs
and computer science from Stanford.
And you are on my list.
And in 1993 before LinkedIn, you had to go do some digging to construct that list.
And I thought, I'm broke.
And AI isn't going anywhere anytime soon.
and I have no idea what to do
and I have a bunch of college friends in New York
and I'll scam this bank for a free trip
and that's how I ended up at Goldman Sachs
and it didn't seem auspicious.
I just liked the idea.
They were doing a project that seemed insane.
The project was we're going to build
a distributed, transactional protected,
object-oriented database
that's going to contain
our foreign exchange trading business
which is inherently a global business
so we can't trade out of Excel spreadsheets
and we need somebody to write a database from scratch in C.
And fortunately, I had not taken the database classes at Harvard
because if I had, I would have said, that's crazy.
Why would you write a database from scratch?
And I don't know anything about databases.
And so I just had the fortune to join as the fourth engineer
and the three-person core SecDB design team.
And then in a very lucky move, one day the boss comes into my office and said,
the desk strategist for the commodities business has resigned.
Congratulations, you are the new commodity strategist, and go out onto the trading desk and introduce yourself.
He was never going to introduce me to them.
And we were kind of scared of them, to be honest.
And so there I was in the middle of the oil trading desk, kind of an odd place for a gay, Hispanic computer game.
to be in 1994 Wall Street.
It's such an amazing story.
And one of my favorite lines, which I believe and I repeat often, is that opportunities
live between fields of expertise.
And I personally love exploring those intersections.
I feel like your career has sort of been at these intersections.
Maybe fast forward kind of into the financial crisis, you know, famously, you know, my understanding
is that SECDB really helped the firm navigate that period and really same total sack.
So what was it about SECDB that was different than other Wall Street firms who
lost billions and millions of dollars in that moment? And how did you guys sort of navigate that?
Yes. Well, this is where we're going to start to get into the pop culture, right? It's because,
of course, you have to mention the big short when you start talking about these things, right? And so
SECDB showed the legendary CFO of Goldman Sachs during the financial crisis, David Vinear,
that we and everybody else had a very large position in collateralized debt obligations, CDO,
that were rated AAA.
So Insect E.B, it's another thing, and it has a price,
and that price can go up and down,
and there's simulations where it gets shocked
according to probability distribution,
and then there's non-parametric or scenario-based shocks,
and we looked at that and thought,
wow, we better do something about this very large unhedged position,
namely, sell it down or hedge it.
We didn't know that the financial crisis was coming,
Of course, who got in the press and elsewhere accused of all kinds of crazy things.
Like, they were the only ones who hedged, so they must have known it was coming.
We were just predictors of the present and thought, better hedge this position, hence the big short.
And the question was, if Lehman fails, what happens then?
And we talk about Lehman as if it is a single thing.
we had risk on the books to 47 distinct Lehman entities with complex subsidiary, guarantee, non-guarantee,
collateralized relationships.
And so it was super complicated.
But in SECDB, it was all in there.
And you could just slip it around.
You could just as easily run the report from the counterpart site.
Now, I make it sound like it was perfect.
It was a little less than perfect.
We had to write a lot of software that weekend, but the point is we had everything in one virtual
place, and it was a matter of bringing it together.
So it's also part of the legend, but it's also factual.
We had our courier show up at Lehman's headquarters within an hour of its filing bankruptcy protection
for the 47 entities, and we had 47 sheets of paper with our closeout claim against,
each of those entities rolled up firm-wide across all the businesses.
And it took many of the major institutions on Wall Street months to do this.
And so that was the power of SECDB.
And of course, it was wildly imperfect, but it was something that nobody else had.
Just to like piggyback on that last point, what impact has regulation had historically
on technologies impact on financial services.
And I think about the different asset classes,
for example, in global markets
that shifted to be traded electronically, right?
Was it often historically driven
by regulatory change, emergent technologies,
both, you know, I'm curious about that
and also how it informs the future?
Yes, well, so regulation's a powerful driver of change
and so is technological change.
And some things are just inevitable.
I'm a strong believer in capitalism with constraints and rules and we can, and we'll have a
vigorous debate about the nature of the rules and the depth of the rules and who writes the
rules and how they're implemented and all that matters hugely, but to say, oh, we don't need any
rules or trust us, we'll look after ourselves. I just haven't seen that work very well.
And so in some cases, the regulators will say something, for instance, in the Dodd-Frank
legislation, there's a very short paragraph that says that the Federal Reserve shall supervise
a simulation. It was called the DFASD simulation. The Dodd-Frank, and I don't even remember what the
rest stands for, right? And that will be part of the job of the Federal Reserve, a simulation
of how banks will perform in a severely adverse scenario. And that was a powerful concept, right? You have
to simulate the cash flow, the balance sheet, the income statement, several quarters forward in the
future. None of this was specified in detail in the statute, but then the regulators came in and
really ran with it and said, you will simulate nine quarters in the future, nine quarters in the
future, right? The whole bank, all of it, end to end. And then, in a very important move,
the acting supervisor for regulation at the time, Dan Terullo, the Reserve Governor, said,
we're going to link that simulation to capital actions, whether you get to pay a dividend,
or whether you get to buy your shares back, or whether you get to pay your people, right?
Because he knew that that would get everybody's attention if it's just a simulation.
That's one thing.
But if you need to do it right before you can pay anybody, including your shareholders and your people,
then you're going to put an awful lot of effort into it.
So that caused a massive change
and made the system massively safer and sounder.
We saw that in the pandemic.
There's actually a powerful lesson for us
in the early days of electronic trading
for the early days of artificial intelligence, right?
There was a huge effort by the regulators to say,
we've got to understand what these algos are thinking
because they could manipulate the market,
they could spoof the market,
they could crash the market,
and we would always argue
you're never going to be able to figure out
or understand what they are thinking.
That's a version of the halting problem,
but at the boundary
between a computer doing some thinking
and the real world,
there's some API, there's some boundary,
and at the boundary,
just like in the old days of railroad control,
at those junctions,
you better make sure that two trains can't get on a collision track, right?
And it's the junction where it's going to happen.
But then when the trains are just running on the track,
just leave them running on the track,
just make sure they're on the right track.
That's going to be an important principle for LLMs and AIs generally
as they start agenting and causing change in the world.
We have to care a lot about those boundaries.
And maybe that's a good transition to present day.
You were a huge force in the digitization,
of Goldman Sachs and Wall Street in general and kind of the rise of the developer as decision
maker, maybe talk a little bit about generative AI specifically today. How is this technology
different from, you know, the AI of your PhD in 1991? And what are the impacts that you see,
not just in financial services, but perhaps in other industries as well? Well, for full disclosure,
I remember late 80s, early 90s and this program at Stanford, we were the Bayesian's, right? And then
we would look at these connectionists through neural network people. And I hate to say it, but it's true.
We felt sorry for them. We thought, like, that'll work. Simulate neurons? You've got to be kidding.
Well, so they just kept stimulating those neurons and look what happened. Now, in some ways, there's
nothing new under the sun. I had a fantastic talk not so long ago with Joshua Benjillo, who's
really one of the four or five luminaries in this and this renaissance of age.
AI that's delivering these incredible results.
And he was talking about how his work is based on taking those old Bayesian decision networks
and coupling them with neural networks, where the neural networks designed the Bayesian
networks and vice versa.
And so some of these ideas are coming back.
But it is safe to say that the thread of research or the river of research that took this
connectionist neural network approach is the one that's bearing all the fruit right now.
And David, the way I would describe all of those algorithms, because they are just software,
right? Everything is turning equivalent, right? But they're very interesting software.
They started off with images, images of cats on the internet. People love putting up pictures
of cats. Well, now you've got billions of images that people have labeled as saying, this image
contains a cat. And you can assume all the other images don't contain a cat. And you can
train a network to see whether there's a cat or not. And then all the versions of that. How old is this
cat? Is this cat ill? What illness does it have? All of these things over the last maybe starting
10 years ago, you started to see amazing results. And then after the transformer paper, now we've got
another version of it, which is fill in the blank, or predict what comes next, or predict what
came before. And these are the Transformers and all the chat bots that we have right now. It's
amazing. I wish we all understood in more detail how they do the things that they do. And we're
starting to understand it. It all depends on the training set. And it also depends crucially
on a stationary distribution, right? So the reason all this works on, is it a cat or not a cat,
is that cats change very slowly in evolutionary time. They don't change from day to day.
But things that change from day to day, such as markets, it's a lot less clear how these techniques
are going to be powerful.
But here they are.
They're doing amazing things.
We're using this in my firm.
And we're using it in production.
And we're deeply aware of all the risks.
And we have a lot of policies around it.
It reminds me a lot of the early Wild West days of electronic trading where we're all
authorizing a few of us to do some R&D,
but very careful about what we put into production.
And we're starting with the easy things.
It feels like a unique moment,
or maybe there's unique to me,
a lot of momentum happening,
both bottoms up and top down.
Bottoms up because, you know,
I don't know, something like 40% of Fortune 100
is using maybe GitHub co-pilot
in some new organization
or Microsoft AI product.
And then conversely,
every CEO or every board member, right, can plug a prompt into one of these models and kind of
understand intuitively the magic and imagine the impact that it could have on their business. And so it
seems like the employees of many of these companies want the productivity gains that you're describing.
Boards are like, you know, how is this going to impact the human capital efficiency of our company?
Like, where can we deploy this technology? I guess when other CEOs of large companies, you know,
come to you for your advice, like, how are you advising them on how to do you?
to deploy AI in their organizations, where within those companies?
Like, what's the opportunity you see maybe in the near term and, you know, in the middle or
long term?
Really, first order of business.
And this is something that we worked on at Goldman for a long time.
And I'm happy that we left Goldman in a place where it's going to be able to capitalize on
Gen AI really, really quickly, which is having a single source of truth for all the data
across the enterprise, time travel.
source of truth. So what is true today and what did we know to be true at this at the close of
business on some day three years ago, right? And we have all of that. And it's cleaned and it's
curated and it's named. And we know that we can rely on it because all of this training of
AI's is still garbage in, garbage out. And so if you don't have ground truth,
then all you're going to do is fret about hallucinations,
and you're just going to be caught in hallucinations
and imaginings that are incorrect and not actionable.
And so getting your single source of truth right,
that data engineering problem,
I think a lot of companies have done a terrible job of it.
I'm really excited about the new Gemini I,
1.5 context window, a million tokens.
Like that one, I just want to shout that from the Mountain,
Like if you've been in this game and you've been using rag, retrieval augmented generation,
which is powerful, but you run to this problem of I've got to take a dock, a complicated dock
that references pieces of itself and chunk it, well, you're going to lose all of that
unless you have a really big context window.
Breaking that quadratic time complexity of the length of the context window is just monumental.
And I think over the next few months you're going to see a lot of those changes
problems that were really hard are going to become really easy. I don't know. What do you think?
Look, I think every company needs to kind of using Goldman maybe as the analogy, so much of the
organization, but in particular even many parts of the federation, I think can and should be leveraging
software. And a lot of those workflows can be augmented with AI, right? From legal to compliance,
to vendor onboarding to, you know, risk management as we're talking about. But I think it's going
to have a profound impact on the enterprise. Obviously, we're quite biased. I guess one topic
that people debate quite often is the impact of regulation on the adoption of this technology.
I'm just curious your view on the government's role in this, you know, in general AI and what
advice you have in kind of accelerating this versus, you know, what responsibility they have.
Well, one of the things that I learned during the financial crisis was a huge amount of respect
for the regulators and the lawmakers. They have a really tough job and really important to
to collaborate with them and to become a trusted source of knowledge about how a business works.
And I just lament the number of people who just go into a regulator and they're just talking
their own book and hoping that the regulator or lawmaker won't understand it.
I think that is a terrible way to approach it and has the very likely risk of just making them
angry, which is definitely not the right outcome.
And so I've been spending a lot of time with regulators and legislators.
in a bunch of different jurisdictions.
And you already heard a bit of what I have to say,
which is, let's please not take the approach
that we first took with electronic trading.
That approach was, write a big document
about how your electronic trading algo works.
And then step two was hand that document over
to a control group who will then read the document
and assert the correctness of the algo.
Right?
this is the halting problem squared.
It's not just a bad idea.
It's an impossible idea.
And instead, let's put a lot of emphasis,
a lot of standards and attestations at all the places
where there's a real world interface,
especially where there's a real world interface to another computer.
So the analogy is, in electronic trading,
there was not a lot you could do
to prevent a trader from shouting into a,
a phone an order that would take your bank down, right? You could, how are you going to prevent that
from happening, right? And, but what you really worried about was computers that were putting in
millions of those trades, right? Even if they were very small, they could do it very fast and you could,
you could cause terrible things to happen. And so another thing I'm always telling the regulators is,
you know, please, please, the concept of liability.
right? They start with this idea. Let's make the LLM creators liable for every bad thing that happens
with an LLM. To me, that is the exact equivalent of saying let's make Microsoft liable for every
bad thing that someone does on a Windows computer, right? They're fully general. And so these LMs
are a lot like operating systems. And so I think the regulation has to happen at these boundaries
at these intersections at these control points first, and then see where we go.
And I would like to see some of these regulations in place sooner rather than later.
Unfortunately, the pattern of human history is we usually wait for something really bad to happen
and then go put in the cleanup regulations after the fact and generally overdo it.
That was the history of Dodd-Frank.
We don't really know what went wrong in the financial crisis.
So let's just go regulate everything.
And I think 99% of it was read to.
tape that did not make the world a better place. And some of it, such as the C-Car regulations,
was profound and did make the system safer and sounder. And I would want us to do those things
first and not just the red tape. Well, I know you're also very passionate about life sciences.
You started your graduate career there and I believe you now sit on the board of recursion,
you know, pharmaceuticals. Yes. Yeah, maybe talk through kind of the implications that you're seeing
for generative AI in life sciences and biotech in particular?
Well, it's epic, isn't it?
I had an amazing moment just a couple months ago.
I had the opportunity of being the fireside chat post for Jensen of Invidia
at the JPMorgan Healthcare event,
and there was a night that recursion was sponsoring.
And we really talked about everything he learned from chip design.
So Jensen, incredibly modest, will say,
Well, he was just the first, in that generation of chip designers who were the first to use software to design chips from scratch.
And it was really the only way he knew how to design it.
And he likes to say that invidia is a software company, which it is, right?
But that seems counterintuitive.
It's supposed to be a hardware company.
And he talks about the layers and layers of simulations that go into his business.
Those layers do not go all the way to Schradinger's equation.
and we can't even do a good job on small molecules, right?
Solving Trainers equation for small molecules,
but it does go very low, and it goes very high to what algorithm is this chip running,
and that's all software simulation.
And he said in that chat that at some point he then has to press a button
that says, take this chip and fabricate it,
and the pressing of that button costs $500 million.
And so you really want to have a lot of confidence in your
simulations. Well, drugs have that flavor, very much so, except they cost a lot more than $500
million by the time they get through phase three. And so it seems obvious to all of us that
you ought to be able to do these kinds of simulations and find the drugs. Now, the first step is
going to be just slightly improve the probability of success of a phase two or phase three trial.
that's going to be incredibly valuable because right now so many of them fail and they're multi-billion
dollar failures. But eventually will we be able to just find the drug? The needle in the haystack
nature of this problem is mind-blowing. There are, depending on the size of the carbon chain,
but let's just pick a size. There's about 10,000 trillion possible organic compounds and there are
4,000 approved drugs globally. So that's a lot of zeros. And if AI's can,
and help us navigate that space, that's going to be huge.
But I'm going to bet that we will map biology in this way.
It's just biology is so many orders of magnitude
more complicated than the most complicated chip.
And we don't even know how many orders of magnitude
and how many wares of abstraction are in there.
But the question is, do we have enough data
so that we can train the LOMs to infer the rest of biology?
or do we need an awful lot more data?
And I think everybody's clear we need more data.
I think what we're less clear on is do we need 10 orders of magnitude more data or 100 more orders of magnitude?
We just don't know.
Amazing time to be alive.
Best time ever.
We say this at the alphabet board.
What an incredible group of people.
And when I hear Sergei and Larry say it's the best time ever to be a computer scientist.
Of course, I agree with that. It's magical.
Totally. Awesome.
Well, Marty, thank you so much for your time.
Always a pleasure.
You've had such a fascinating career,
and we really appreciate you spending time with us.
David, great talking with you. Be well.
Thanks.
I'd like to thank our guests for joining in the vault.
You can hear all of our episodes by going to A16Z.com backslash podcasts.
To learn more about the latest in FinTech news,
be sure to visit A16Z.com backslash FinTech
and subscribe to our month.
monthly FinTech Newsletter. Thanks for tuning in.
