The Checkup with Doctor Mike - Who's To Blame If You're Fat? | Dr. Mike Israetel

Episode Date: December 11, 2024

I'll teach you how to become the media's go-to expert in your field. Enroll in The Professional's Media Academy now: https://www.professionalsmediaacademy.com/Follow Dr. Mike Israetel here:​YouTube - ‪https://www.youtube.com/@RenaissancePeriodization​Twitter/X - https://x.com/misraetel?lang=en​Instagram - https://www.instagram.com/drmikeisrae...​Facebook - https://www.facebook.com/michael.israetel/​Team Full Rom - https://teamfullrom.com/00:00 Intro00:55 AI11:21 Political Anthropology16:28 Rich vs. Poor25:16 Nepotism / Prime / RFK Jr.47:15 Obesity and Poverty1:15:36 Obesity and Genetics1:21:38 Obesity and Social Factors1:37:05 Free Will / College Ideology1:43:58 Conscientiousness1:57:22 Muscle2:03:30 Mike’s Hypocrisy2:09:58 Who Benefits From Weight Loss?2:14:52 Muscle Mass / Big InvitationHelp us continue the fight against medical misinformation and change the world through charity by becoming a Doctor Mike Resident on Patreon where every month I donate 100% of the proceeds to the charity, organization, or cause of your choice! Residents get access to bonus content, an exclusive discord community, and many other perks for just $10 a month. Become a Resident today:https://www.patreon.com/doctormikeLet’s connect:IG: https://go.doctormikemedia.com/instagram/DMinstagramTwitter: https://go.doctormikemedia.com/twitter/DMTwitterFB: https://go.doctormikemedia.com/facebook/DMFacebookTikTok: https://go.doctormikemedia.com/tiktok/DMTikTokReddit: https://go.doctormikemedia.com/reddit/DMRedditContact Email: [e-mail] Producer: Doctor MikeProduction Director and Editor: Dan OwensManaging Editor and Producer: Sam BowersEditor and Designer: Caroline WeigumEditor: Juan Carlos Zuniga* Select photos/videos provided by Getty Images *** The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional **

When I found out my friend got a great deal on a wool coat from winners, I started wondering. Is every fabulous item I see from winners? Like that woman over there with the designer jeans. Are those from winners? Ooh, are those beautiful gold earrings? Did she pay full price? Or that leather tote?

Or that cashmere sweater? Or those knee-high boots? That dress, that jacket, those shoes. Is anyone paying full price for anything? Stop wondering. Start winning. Winners, find fabulous for less. If I was still working at the university, I would never give this interview.

Because saying that poor people on average have lower conscientiousnesses, I'm still worried about this going out. Holy fuck, that's insulting. If you're nuanced, then you're smart. You can understand how it's both real and not insulting. But if you're anything else, and if you're very politically motivated, it's going to be a nuclear bomb. You're blaming people for their problems.

Please welcome return guest, Dr. Mike is. Retel Ph.D. to the Checkup podcast. We had a very scientific, even philosophical discussion about the nature versus nurture debate surrounding obesity. We get into that and so much more muscle, its implication on your health, what's hype, what's not. You're going to enjoy this conversation. I know I did. Let's get started with the Checkup podcast with Dr. Mike Squared. I remember last time we talked to us, I don't think you read comments and feedback and stuff. I do sometimes. Like I was looking at feedback at our conversation,

and a lot of people were saying that they don't believe AI is exponential as you say it is. Yeah, they're just categorically wrong. This is not really like a debatable topic for people who are deeply entrenched in the field. I can approach this from a variety of angles to illustrate this point, but it used to be that the number of people

that were saying that artificial general intelligence, roughly human capability intelligence. Back in the late 90s, the vast majority of AI researchers thought it was some combination of impossible or would arrive later than 2100. Every single five years that they do investigations

into what the consensus of the AI profession is, that number falls lower and lower and lower. Up until, and originally Ray Kurtzweil was kind of the real, kind of not the father, but one of the main progenitors of this idea that AGI is coming much sooner than people think. his original progostication date was 2030. He later revised that to 2029, which is oddly specific.

There are conversations now among the CEOs of Anthropic Open AI, various people at Google. These are the people making these things. And the conversation is now is like, are we going to hit AGI in like 2027 or is it really going to be 2029 or somewhere between? And so the entire profession has been coalescing into more and more aggressive prediction timelines. And so the idea that, like, I'm overly pessimistic or, sorry, overly optimistic about it is I've just read enough about it to understand, like, this is the space that we live in. And the pessimism, there's also another thing. There's a well-documented human intellectual fallacy called a pessimistic fallacy. And most humans on average are more pessimistic than they should be.

But it's also understandable because humans evolved in an environment, most of our brain and the way we think was designed in periods of evolution. where hunter-gatherer survival was how we made things happen. Hell is a pretty good way to describe what that was like, you know, elements of paradise and lots of elements of hell. And things also just did not get better over time in any measurable way. And you could absolutely depend on things getting real bad real soon for most people. Like the average age of survival was like 30, so on and so forth. So that's where our brains kind of have a baseline feel of what's happening.

And over the last 10 to 5,000 to 10,000 years, there's been an exponential growth in culture and society and industry that means that we're really out of touch with the rate of progress. We're not usually exponential thinkers. We're linear thinkers. Almost nobody predicted the internet.

And I believe in 1997 or 1988, Paul Krugman, Nobel Prize winning economist, had a comment that I'm sure he regrets making, which is the internet's probably not going to go anywhere because most people just don't have much to say to each other. I mean, like, we're laughing at it now. He also recently, I believe, please don't take my word for this.

You should verify this, but I think he also, a few months back said something negative about AI as well. He'd be tripping twice in his life, unfortunately. But the internet was that this thing that is just straight up pure magic. Like, think about Amazon. Do you use Amazon? Like, you think of something and you actually don't even have to type anything anymore. You go, hey, Alexa, can you order me X, Y, Z?

I don't use that. Me neither. My parents do. She's great. She's not even an LLM yet, believe it or not. She's not a large language model. Like, they've yet to upgrade. her to that. Um, but, uh, you go on your phone and you go like protein bars and it finds

the one you like and you go, okay, click, go hit. And then like it arrives between five and seven p.m. that same day. Like how? How? That's insane. We live in an insane time already. Imagine telling someone in the 90s like, dude, you can just like, you'll have a cell phone and they're like, okay, like one of those big ones. You're like, it's much smaller, but way more power, like a hundred times more powerful in your best desktop today. Like, okay, it's going to be in your pocket. get all the time. They're like, okay, so the rich have it. Like, everyone in the world has one.

Okay, you just click on something and it just arrives later. Like, where's arriving from? I actually have no idea, but I don't care because it arrives on time. You can think of about 100,000 different ways in which we take totally for granted, the fact that we live in an era of insane abundance and prosperity and predictable improvement. And so combining all of that together and saying, well, Mike's like a bit too optimistic about AI, I would say I'm probably on the aggregate when I hopefully am a lot of and 20 years look back, I was probably like more optimistic than most people, but still more

pessimistic than the reality that occurred. I think about rate limiting steps in the exponential growth, because I absolutely can see the amount of growth that we've had in scientific understanding, achievement. In fact, there's a great book called like the Half-Life Effects that initially was doing research to prove why we have so much scientific breakthroughs. And a big part of it is a pretty cool statistic where 80% of scientists that have ever lived are alive today. Oh, yeah. Because this is the time when they started becoming scientists.

Sure. It used to be very rare to be a scientist. And through that collaboration, there's been an exponential growth. But then there's going to be a rate limiting step because there's not that many people to keep growing the field of science. AGI will solve that problem. So that's the next factor that comes into it. Amazon and the reason why its ability to be at the level where it is is because, of incentives. And incentives aligning creates a really clear road for something like Amazon

to occur. So you have incentivization from capitalism, people that want those products, the products being able to be made at a reasonable way, area for storage, all these things aligning together, because we all uniformly agree, that's what we want. And I think it's very easy for incentives to shift because humans are not always rational. And there's a lot of emotional components, wars, political divisiveness, disease that can interrupt the algorithmic growth that we've seen in the past. It has never interrupted it up until never. So if you look at all of the important events in geological history, biological history, biological history, cultural and anthropological history

and the history of development technology and civilization, you can plot them all on the same log scale and they basically don't move up and down accounting for wars, holocausts, massive natural disasters. There's a reason for that, at least a candidate hypothesis. It's a very mysterious thing to see in the data. The data's crystal clear about it.

How the hell did World War II not slow down progress? Because there are two things that allow progress to happen. One is abundance. Like, you know, you have time to work on cool shit. You have money to work on cool shit. You develop cool shit. The other is incentive. The impetus to make something happen because of difficulty.

And these work kind of as top and bottom end buffers to the rate of progress. When you have good times, you have a huge abundance. But not a lot of incentive to make shit happen that's cool because it doesn't matter. Everything's kind of nice. So who cares? Like, really, is it really more important to make the next amazing iPhone? Like, the iPhone's pretty goddamn good. who cares. However, when you get into wars, natural disasters, that's when the incentive

to make radical innovations really pops up and seems to cover that difference. So what we see is a very homogenous rate overall. Now, there are absolutely declivities and proclivities throughout, but in the grand historical sense, they seem to so far be very minor. Like the Cambrian explosion of life on Earth seems to be a big deal when you look at it. But when you spread out the timeline, you're like, oh, actually quite predictable if that would have happened, I guess. It's all on the same curve, so. Yeah, I think about it, like I think of when investors pitch you their deck, and they say, what's that line?

Past results don't necessarily reflect future outcomes. Sure, sure. And I say all of that with that in mind of how the future plays out. And it's been interesting how the natural human buffer that you discuss exists and has guided us here. And then there's also the regulation of it all and the wars and the economic progress of it all. Like, there was talk about social media just continuing to grow in a way that was becoming unreasonable. And then you see young people say, well, I'm kind of getting bored of doing the same

thing of posting perfect images on Instagram. Now, you know what? The less tailored, less structured. Streaming. Yeah, live. Yeah, live. So, like, it's not always been clear to me how the future will adapt to current technologies. And I'm always aware of that when trying to make predictions. And that's why, even though I probably would have agreed with someone who is very poo-pooing AI 10 years ago, but not because I too-pupoo AI, I just poo-poo their ability to make a good prediction. Sure. Most predictions that are very specific end up getting a lot wrong, 100%. But we can just go based on generalities. The amount of total intelligence in our society has been increasing exponentially for all of measured time, and it looks like it's going to continue

to do that. They've done lots of work on theoretical limits of intelligence based on like physics and information theory. And the limits of intelligence are preposterous, like way out of reach of anything you could surmise. Like you could hypothetically turn like a decent fraction of the Earth's mass into a computer. And like the amount of intelligence it has is like humans are like a fungal growth on the Earth's crust level of like occupying the solar system. People like, what about physical limits? Like you know, we could just mind Jupiter for matter. And I can't, like, the, there's like a storm on Jupiter, the, the, the, the, the eye or

whatever, that's like three times bigger than the Earth. Like, it's a lot of hydrogen, you know, so the thing about physical limits, you don't really get a big limit on that one. And then you think about trajectories, trajectories have been good so far. And you think, okay, so if intelligence increases a little bit more and a little bit more and a little bit more, you can start to see certain problems kind of melting away because a lot of the problems that are extant right now because of a lack of intelligence. Here's something fun and wildly politically incorrect.

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when you switch to a Scotia Bank banking package. Learn more at Scotia Bank. Bank.com slash banking packages. Conditions apply. Scotia Bank. You're richer than you think. So as you measure people's political opinions, you scale them against proxies or direct measurements of their intelligence.

There is a massive degree of consensus on political opinions as intelligence scales in either way. People who are less intelligent on average measured however you like tend to be more authoritarian in both regard of social and economic freedom. So people that are less intelligent tend to not be for social liberties and not super big fans of gay rights, trans rights, women's rights, the whole thing. And they're not big fans of economic freedom in general. They seem to think that more government regulation is the way to do things. Like any time they see something wrong, they go, there should be a law that against that. People on average as they become more intelligent seem to become more libertine in their attitudes. They favor a freer economy, substantially less, more intelligent regulation.

And they favor more libertine approach to social things like live and let live kind of. attitude and so if you manage to increase the amount of intelligence in the system it's going to cause a predictably better place for all of us to live because when you have uh peoples that tend to be lower intelligence on average running an institution or country wherever they generally run it really poorly and you have all of the social maladies that you can see in a variety of areas whereas as people become more intelligent or as the aggregate of people plus machine intelligence becomes better things get better overall. And so if you scale that out, at some point, you're like, man, if our collective IQ,

us plus machines goes up another 10 points, a lot of places are going to be free or more prosperous and cleaner and more stable and have less war. Because if you think about it for like a little bit, you know, basic economics, severe basic economics, war almost never makes logical sense. Almost ever. Like should we attack the Netherlands? Why? To get the resources.

Like, we can just buy the resources. We can get them for free. Like, no, you still need to buy them because then some of us live there and they sell us that stuff like the whole war for oil nonsense is just almost certainly just pure nonsense there's all the war for oil in the modern time has just not occurred well that's that emotional reasoning that we're talking about humans so like as you scale up your intelligence your emotional reasoning tends to capture less and less of your cognitive bandwidth i don't know if i agree with that it's just demonstrably too empirically well on average now they are absolutely exceptions of smart people

you're really having a lot of feelings i'm not talking about the extremes i just see that like as IQs and noble laureates have attested that they oftentimes are able to convince themselves of wildly inaccurate theories and the belief that whatever they're saying is true when it's absolutely not true. That's also been shown. And then also there's a chicken or the egg effect here where it's when you're poorer and have less education, you need to have a little bit more of an authoritative mindset to succeed in order to be practically successful. and when you're wealthy and you have less to worry about, you think about being more free

and you think about other things whereas when you're poorer, you have to survive so that it frees you up to think more liberally and peacefully, which is why there's always so much disagreement of people who live on the coasts that have money versus people who are struggling to be rising in society and they want their children to focus and live the most strict lifestyle

because they think that's the only way to achieve it and they could be right given their circumstances. Do you think that could be a reasonable thought? Maybe. So to the first point of Nobel laureates questioning their ability or illustrating their ability to sort of justify anything they'd like,

the fact that they're introspective enough to know that that's happening is already alienating them and alone to the group. Well, I don't think they're aware of it. I think we studying them are aware of them. Oh, I see. I think some of them have talked about it openly.

Maybe. And we are being less intelligent than local Nobel laureates are probably less self-aware than they are. And if we're self-aware of it, you have to ask, what about people of substantially lower intelligence? They're substantially less aware in general. And so they're apt to make mostly emotionally biased choices. As a matter of fact, many people,

when you ask them what they think about politics are answering a completely different question. They're answering, actually, I'm wearing my Thomas Sol shirt to illustrate that exact thing. as a former position of his, current position of his. Most people feel a certain way about politics. They don't think a certain way about politics,

which is the wrong thing altogether because politics is asking the question of, how do you run a society for the maximum benefit? However you define that, it's a technical question. It's a machine question. It's not a question of how you feel about things. Most people feel rather than think about these kinds of topics, people who are more intelligent tend to think on the margins more than not.

And people who are less intelligent tend to feel more than not. And so on average, if you think Nobel laureates are biased, you should talk to someone of profoundly lower intelligence and you will see probably exclusively biased and almost nothing else. I wonder what the research of that actually shows. From an anthropology standpoint.

Give it a look. Yeah, because, no, no, no, like even from a practical standpoint of what I've experienced in my life of, I treat two very distinct populations of where I practice medicine, where I have people who live in the wealthy community where my hospital exists, and then I have people who are coming in for the community health aspect of it, charity care aspect, perhaps that are employed by the people who are very wealthy.

And I see the problems that they experience, their logic by how they approach the world, and the strategies that they each use to survive. And they're radically different in terms of looking at them on paper, but they're radically appropriate given their situation. I think if you're, I think if you're a single mother who's working two jobs, have two children, one of which that's struggling academically, you don't have the capacity or time to think about what a better world looks like for certain subsets of individuals. You're trying to be as practical and create the guardrails for the success of your immediate family.

I think looking down upon that as dumb or wrong, I think misses the point of how that person got there. And therefore, we're judging a whole group of people for making a decision that had we been in that situation, we would have made the same exact decision. I don't agree. You don't agree. No.

Why is that? Oh, boy. So a couple of caveats. We're speaking in statistical generalities. so we're not trying to paint an entire group of people anyway. The group of people we're painting is also a statistical abstraction. It's not an actual group of people you can point to.

One example of this is people talk about the poor, but like something like a third of the poor or just like people who just graduated high school, most of them will end up quite wealthy. They're just at the wrong time of life. So you can't group them in with various other demographic groups that are poor consistently throughout their lives. And when you talk about the rich,

it's about how much money they have? Right. Or how much they have? They earn this year, because as Thomas Holt says, that's not always the same. That changes every year. All the time, yeah. Because the people that are extremely wealthy

may not have earned a lot. Sure, sure. And they're also within any kind of category, let's just say poor people, they're vastly different kinds of people in that with vastly different kinds of behavioral patterns. But the behavioral patterns seem to be the number one correlate

of what continues to keep you poorer than average or continues to push you on the trajectory of wealthier than average eventually. So when we say on average, people do X by Z, you can give me millions of counter examples of poor people being very diligent, very organized, very conscientious, very thoughtful, and very coordinated in their action. And those people are much less likely to remain poor than the fraction of poor people that have the opposite of those characteristics. So when you look at wealthier people and poor

people on average, you tend to find that wealthier people on average more conscientious, more goal-driven, more organized, clear thinkers about things. They have lots of feelings just like everyone else, but they don't let the feelings take over as much as people on an average who are poor. But the averages kind of belie the fact that it really goes individual by individual. And whether or not you're rich or poor, you have no doubt, well, maybe no doubt. Some people are not capable of having as many social interactions, but you've met at least four kinds of people, likely. Poor person who is like just a really conscientious, really organized, really thoughtful, calm person, very intelligent, very motivated to improve their circumstance,

even if they've been dealt a nasty hand. Like they had married someone who was really good to them. That person died in an automobile accident, left them with three children, and now they work two jobs, and they're doing their goddamn best. That person and their children, through the genetic relatedness of having those features inherited from them and the very nice father that unfortunately was taken too early, their children and them will probably be over time on average, expectedly rising. through the income strata because they're just good at stuff that's just who they are they don't

spend excessively they don't make impulsive decisions as often so on and so forth so that's subtype number one subject number two of a poor person is when you like hang around them for long enough you're like don't say this to them personally but you could be like motherfucker i'll tell you why you're poor god damn it you spend all of your money you're addicted to like 10 different things you have an i don't give a fuck attitude about basically everything you've never invested a dime and improving yourself in any way whatsoever you're rude to everyone around you how are you possibly going to make money and hold on to it in almost impossibility so there's two subtypes of poor people so for that second subtype is that caused by society a societal situation or is that a genetic

situation it's a combination of the two but genetics explains much more of the variance as far as literature i've consumed um because both poor people are both a subject types of poor people are exposed to roughly the same social influences and it does not affect everyone the same way. There are some cultural elements there that have to be thrown in because there's kind of like society at large, there's genetics, but there's also an intermediary variable culture. How do you process society and express your genetics? There's probably something to say for culture, though based on the more recent behavioral genetic data that I've seen, people in some sense secrete their culture based on their genetics, at least to some great

degree like if you're the kind of person that's born into uh even a family of very highly unconscious people but you have a lot of trait conscientiousness and they introduce you to a very low conscientious culture like just fuck it do whatever yolo you probably as you mature into teenagehood will be like this sucks i think the fuck out of here you know like the small town let me get me get me out of here i'm not made for this kind of thing so we have two of those people so far two archetypes are very rough right and there's also just to finish that point yeah i think there's a protective factor in the correct social group. So how many kids that may, let's say,

genetically have an issue with addiction, with lack of delayed gratification ability, all those factors that we label as potentially successful? Like, they have low levels of that. But if they're in the right social class, they're born wealthy into a wealthy family in the United States,

will they make mistakes and suffer consequences? Absolutely. But it's protective in the way that they're not going to become drastically poor. You just made category three of the four. So category three is people who come from wealth, but exhibit very low conscientiousness,

and they tend to have that protective buffer, but you can work your way through any protective buffer, and through multiple generations of low conscientious individuals, you can lose absolutely everything and just become absolutely destitute, no problem. Say gambling addiction can cancel out every single bit of generational wealth in a matter of minutes, if you think about it,

definitely hours and days, for sure years. A profound drug addiction. I would like to believe in a world in which people who have a huge proneness to drug addiction, you simply give them the right access to care and they're better. Mike, you've seen the data on drug recovery rates. It's not pretty.

A lot of wealthy people who have all the resources who are prone to drug addiction just continue to, I'm not going to name any celebrities, continue to struggle with it their entire lives. And so, yes, the buffer is real, but we can't paint the buffer too strongly as like, you're never going to be poor. Oh, you can, you can recess down. Yeah, what the data...

Much easier to lose than to gain. Yeah, what the data shows about specifically, let's say, substance abuse is quite interesting in that if you look at people who are struggling with substance abuse in decade three of their life, checking in back in with them at decade five, the odds that they still have a substance abuse issue is not as high as you think it would be. So really a lot of times it's about buying time to get past this issue by a means of risk reduction. And that could be taking a pharmaceutical medication to get you off of that medicine, even though it has side effects. It could mean trading one unhealthy habit like substance abuse for a healthier one.

How many people cope with issues in their lives through abusing themselves in fitness or maybe overusing testosterone because before they were addicted to heroin and and they've gotten off heroin, but they still miss that rush or whatever it is. And they're getting it elsewhere in a slightly less negative way. So it's pretty interesting to see how, if you look at humans in one point in their life, that doesn't always equate,

like we say people who have substance abuse. The same way that it's unfair to say people who are rich this year or earn the most this year, the top 1% this year, it's not gonna be next year. The same holds true for people with substance abuse. Yeah, and every other factor as well. That's an excellent point. But the other last category is people who are relatively wealthy already and also have high trade conscientiousness.

And those individuals tend to have extreme amounts of continual success and aggregate high amounts of intergenerational wealth. I've met a few folks who are from old money, old money. And one of the things that stood out to me about them was how many of them were just mega degenerate losers, just totally just riding it out. What also stuck out is how many of them were just unbelievably awesome. Awesome, kind, conscientious people that you're like, I can tell you why your parents were successful because you're related to them and you got the same thing. Like I know at least one person who came from money, money. And he's on like his third $100 million business creation all by himself. No help for mom and dad in any capacity.

Just like, same idea. No help for mom and dad. If you have a protective buffer behind you, the amount of risk you're willing to take on is going to be greatly different. I have an exact counterpoint to that as an intellectual exercise. If you have no impetus to succeed because it doesn't matter because you're already rich, you have arguably much less drive to make it. People who came from very little always recount the fact that it's because they came from very little that lit them up and made them drive.

Whereas we're all familiar with the trope of the wealthy person that goes to Dartmouth, but like they take whatever classes they feel like taking because who gives a shit? Dad did hedge funds and I don't have to do anything. So how do you traverse that? The way that I think about it is they want to do better than whatever goalpost was set for them. You know, speaking of tropes, Daddy didn't love me because he thought he was more successful than me,

so I'm going to outdo him. Or my dad started a billion-dollar company. I want to make a $10 billion company. Sure. I think that motivation still exists for that. Definitely, but it also, I think, works the other way where people who have seen close to the bottom really don't like to be close.

to the bottom and they're maybe less likely to be lazy about things and just let it ride sure but how much the connections matter like coming to america for almost not at all come on that's complete nonsense almost not at all come on that's complete nonsense i'll even give you a practical simple takeaway for moving to america not having a connection for a plumber a car repair person a dentist versus someone who has all that and then that frees them up to have the time to work more to achieve more to have the buddy-buddy relationship of a grant going their way is an inherent advantage. Yeah. So how can we say that it's not?

Yeah, yeah, it's short-term advantage. It definitely makes things easier in the short-term for you, but usually that stuff doesn't last. So if you have somebody who's been connected into business, like dad was in the industry, said, hey, hire my son, you know, that sort of thing. Sure, nepotism. Business is ruthless. I don't give a fuck who you're related to.

If you're related to dad and he said, how are you? You don't perform. Your stock trading isn't up to standard. I'm going to hire some dude from China. That's a fucking Merck. And he doesn't give a fuck. And I don't know him.

I don't know his parents. There's so much nepotism. There's so many people who are terrible at their jobs at the highest levels. Yeah, many. But it's much rarer than you may think. And there are also so many people at the highest levels that are just good.

And over time, especially the free market. Now, government's slightly different, but the free market, private institutions, private companies, grotesquely overreward capability versus anything else. You ever been inside Google

and no offense to anyone, all jokes, all love and respect? Google, all the companies associated with that tech sphere. Bro, it's like one half of the nation of India. Is there some kind of thing where people just love Indians at tech companies? No, they're fucking Merks.

Do they're fucking good. They're just good. And like, I'm going to hire people that are good. And it's also, we like to hold two thoughts in our heads at the same time about, you know, the myth of the, maybe not myth, the exaggerated form of the greedy capitalist.

It's both a nepotistic asshole and a greedy asshole. Nepotism and greed don't work very well together because if I'm greedy enough, I don't need you, my son, working for my company because you're flubbing. I need, you know, Garage Patel working for my company because he fucking comes in at six in the morning. I don't think he ever leaves.

His portfolio looks like someone make belief fit into existence. I want to get this guy. Who is the current, was it CEO of Microsoft or is it Google? One of the guys is like an Indian dude, right? Yeah, I think. Where do you come from? Where was his advantage?

What I've seen, anecdotally speaking, the practical version of what you're saying is you're the greedy asshole that hires his son who's inept and benefits from the hard labor of the Indian dude without paying them fairly. I think that's the more reality. And then the greedy person is. And then the Indian dude smarter than all of you. And the Indian dude gets us. startup going and he crushes you and buys out your company.

How often do we see that happening? All the time. I feel like the big companies that have been in power are still in power. The blue chip companies. Google was founded by a Russian immigrant in the 90s. Yeah. This is during a period of transition of new technology, of a new industry being formed, as opposed to an old industry being taken over.

So which industries are the ones that are like the old boys still? Disney's not an industry. Disney's one company. Well, Disney's industry is media, it's amusement parks, it's entertainment. Sure. Sports, you don't see brilliant engineers taking over sports teams. You think the profit margin on sports teams is huge. Huge.

Is it the margin huge or is the revenue there? The valuation is huge of change. That's the real value. Sure. And nowadays, you can't buy a sports team. it is now firms that are run by the same 10 people that are buying sports teams. 10 people is not,

so I'd say 10 people are probably ruthlessly competitive against each other. Sure. It's a very competitive landscape. Another thing is, to the point of behavioral genetics, one of the reasons that nepotism actually still can be tracked statistically

is because nepotism on average works, because if you're a real smart dad and you had a great company, yeah, your son might suck relative to, everyone else at the company because they're all studs compared to the average person your son's a killer and so over time i think you see this effect that can be labeled as purely nepotistic but in reality we're just tracing the effects of behavioral genetics like people related to really smart really capable people are on average smarter and more capable than everybody else and so a huge

degree of nepotism can be accounted just sheerly based on that and over long historical trends nepotism has a way of not working out so well because private enterprise does not care about nepotism. So like the Paul brothers, I don't know which one of them made the prime drink. You know the prime drink? Sugar water, Logan Paul. I attack, not sugar water actually.

It's an official sugar water. Sweet tasting water with electrolytes and stuff. So, um, whose brother just attacked me two days ago actually? Attacked in physically? How, uh, social media. Oh my god, even worse. Yeah. Uh, well good, you've got, you had a coming.

What was the attack about? I'm curious. He called me a book thumping sheep doctor what does what does mean sheep doctor oh like she judged me for reading books i guess oh i got you yeah not big on the thinking that man very well yeah uh wow i didn't think we would have like middle school level bullying in adulthood but here we are i found it interesting like if you are what did you say that made him upset i'm sure he didn't reach out for no reason politico posted that president trump wrote that he wants to hire rfk for hHS and he confirmed it

and i wrote it's a sad day for us in health care i see And he took offense to that. Politics makes the mind go a little crazy at times. Yeah, book reading is good, makes you smarter. Well, apparently not. Apparently makes you a sheep doctor. And he said I was indoctrinated. But the doc was in quotes.

Lots of indoctrination going around. I assume he probably has labeled you, but lots of indoctrination. So you've got to take the good with the bad. But I digress. Yeah, so you're saying the Paul brothers. Prime drink. It just tastes really good, man. You like it?

I don't particularly like it, I think it's fine. So how are you saying it tastes good? Everyone I've ever talked to around me says it's amazing. Really? Absolutely. And like they're making it. Yeah, yeah, yeah, sure. So it tastes good enough for lots of people to buy it. Right.

And there are no Pepsi Cola hardliners left to defend Pepsi's enterprise. If something's better, people just buy it. Tesla with Elon Musk. What do you mean? RFK just tweeted that he's going to remove high fructose corn syrup and Coca-Cola and put cane sugar in and that's going to fix our problem. Thank God. finally someone looking out for the people.

I mean, like, come on, like, if we're talking about science. Yeah, yeah. So, hold on, the whole RFK situation. Isn't that the prime example of terrible nepotism in success? I don't think RFK is a nepotistic thing. I think RFK just really, like,

connects with people in a really simple and plain way. Mike, come on. I'm dead serious. Yeah, but how did he? There's lots of other candidates, which are really annoying and people hate. There's a lot of RFKs walking around right now that are not in the,

level of where he is simply because of his family what do you think his family did for him to help him out specifically money look what did he use the money for how did he use the money to become famous how did he run his presidential campaign how do he get media how do he hire p i think he's private kennedy money for them of course i thought it was fundraising he lived yeah how do you get fundraisers how do you get attention how do you create people to want to pay attention sure born famous i guess just because you're a kennedy it's real tough to get a lot things going behind you I think he has some special qualities. I think he comes off as incredibly genuine

when he's conversing, which is super important. He doesn't have that Hillary Clinton, you know, that Illuminati stare where you're like, there's no one in there is there? Yeah, I don't know if that's a good thing. Yeah, well, people seem to like it. And so I think that's probably mostly why. Now, obviously the Kennedy name doesn't hurt.

And nepotism and politics is a much bigger deal than an economics. Well, wait, go back to the Paul brothers of it all. I want to see where you're going with that. The prime drink is good because it's good. And people don't care. They don't care who made it. They're not trying to honor anyone's memory.

You don't? You don't think they're buying it because they want to support Logan or they love Logan or they think he's cool? Oh, there's not enough people that like him to make the economics work for like regular stores and stuff. Hell no. You think random people that are going in to buy prime

that made it what it is don't know who Logan Paul is? Oh my God, tons. Yeah. I barely know who Logan Paul is. I think him is a brother named Jake. or something like that. I couldn't pick them, I couldn't tell them apart. I mean like almost 100 million people

watch Jake fight Mike Tyson, fight Mike Tyson. I mean, I watch a lot of shows with lots of famous people. I don't go running to buy their drink all the damn time. Right, because social media creates a parasocial relationship, which is much stronger. If their drink sucked and maybe it's not that great

and maybe time will tell, no one gives a shit, no one's buying your drink because it sucks. You can say you like a bunch of stuff, you're not going out if you were ready to drink a shitty drink. You might do it once or twice. Like, oh, I really wanted to like, like Jake Paul's drink, it didn't work out.

If it's good, it's good. And over the long term, people who are able to innovate and create great things rise to the top of the ability to have great wealth and influence. And it doesn't happen quickly in all places, but in a relatively more free economy like that of the United States, it happens as a substantial rate.

So while nepotism is still a thing, over the long term, nepotism is really difficult to hold on to unless there's an aggregate effect of nepotism, making better products and services for people, which is why when you run a Fortune 500 company and your ass is on the line for all the stock does, nepotism becomes a really faint whisper. If someone's like Google had a bad year and someone in Google's like, hey, you need to hire my

son, the board is going to be like, are you out of your fucking mind? We need killers. We need people to turn this thing around. When everyone's ass is on the line, nepotism becomes a cruel joke. and what people really want is raw, ruthless, greedy capitalism, people that can make stuff happen. And over the long term, that means that most of the people that can make stuff happen and to being a real smorgasbord of individuals,

most of whom don't have an epitism. You look at all the best people in industry around New York, San Francisco, L.A. Bro, it's a goddamn rainbow out here. Like, I straight up have a policy of hiring as many Nigerians as possible as have yet to meet a Nigerian that's not amazing and everything. I don't know. They're very distantly genetically related to. to me. I don't care. They're just awesome.

What do you take away from the fact that most family businesses fail after two or three generations? I forgot what the exact business is. Not that great then, huh? Well, the question. Most businesses in general fail within several years. So I'm not sure how to put that statistic in line with the family statistic. You know what I mean? I think about nepotism and how it demotivates, but those people still have generational wealth that continues to earn the money. So I don't know. But let's, let's move on. off the nepotism topic, because I do want to discuss about the topic that you brought up obesity and how it's impacted by perhaps genetics, social standing. And I've had tons of conversations

about this with food industry experts, food political people. Just last week, it's not public yet, but we had an interview with a bariatric surgeon, who's a director of the NYU bariatric program I'm here, endocrinologists to talk about GLP1 medications. And they all kind of have a slightly different take on all of it. So I'm curious what your take is. Well, they're all wrong. I'm just the smartest. Obviously, you're Dr. Mike.

And the most handsome. There's no Dr. Mike that's wrong. When you arrive at the Dr. Mike status, you're just, that's nepotism. Yeah, that's done. Like, get on in here. Enjoy the wealth. So this has been a passion of mine for a long time because I'm an astute dilettante delusional, recreational student of economics.

There's a lot of verbiage. I failed SAT. Excellent. Keep up with that. Same. So I just made up a few words. And I have been poorer than almost every American because I'm from the Soviet Union. It's a level of poverty that is difficult to comprehend.

I was high on edible marijuana one day. And I had this revelation that back when I was younger and still to this day, I have like an odd nostalgia for the 50s in the United States. Man, see, you know, like, the good old days. Madman. That kind of shit. And I was like, you know, I think I figured out maybe why. It's because in the 1980s in the Soviet Union, we were kind of at economically a similar

level at the 1950s in the United States. Maybe not even so. Bro, exactly. I asked chat GPT and it's like, it's usually really polite. And it was slightly less polite and more like, God, no. The Soviet Union in the 1980s was like America in the 1910s or something. I was like, oh, my God. So that was thrown out entirely.

So, you know, levels of poverty to where, like, people say, like, there's people say, like, I'm struggling to eat. And you look at them and they have a BMI of 35. And you're like, it can't possibly be true in a way that you're describing it that's linear. But back in the Soviet Union, like, yes, like getting food was by no means clear a thing that you were able to do every day. So then, you know, I had all these experiences growing up. And then I was taught later in various school programs that poverty was a cause of obesity.

and I found that to be baffling, and I've been trying to digest it ever since. Okay. And I have been perusing various fields of literature to try to align my ideas on the subject, and I've come away with some maybe take home points. You mean to prove yourself right? To prove my, not just to prove myself right,

but to give me that feeling inside that, fuck, I just got it all figured out. You know, me, me, me. A little cognitive reassurance. Generally, I just stared at a picture of myself and that's good enough, but sometimes ideas get in there. So I didn't like everything I found out. So the following is heavily caveat to say I need it all in the best possible way.

Don't kill the messenger sort of situation. We're going to kill you. Don't worry. Oh, God. There's a few people in the studio. Which one is it coming from? So as long as I'm sacrificed for big pharma, all as well. And here's kind of how it looks to me.

the typical argument or arguments for poverty causing obesity if you ask a next level of questions about them, things start to fall apart. Level one of questions is like, how do people with more resources with which to buy food end up buying less food?

Can I play devil's advocate on all those questions? Absolutely every single one because I have many retorts to every single adult advocacy point. Okay, so say the first question. How do people with more resources, sorry? How do people who are wealthier seem to be consuming less of a thing that costs money than more? It is at least requires a more complicated logic.

And as you know, with Occam's Razor, the more complex your logic becomes just on very carte blanche levels of thinking. It becomes less likely to be true. So if someone says, okay, you take someone. from the 1600s, and you go, when people get richer, they get fatter. They're like, facts. And like, just kidding. It's actually the reverse. They're going to be like, what?

At face value seems to be very confusing. Sure. And so you have to. There's a lot of that in science, though. Sure, of course, of course. And then you have to start walking down of like, well, what are the intricacies here? And we can address all the intricacies in turn. And they start to paint a little bit of a different picture, a picture that is not super

politically correct, but also can be, I think, more closely lined with reality because one of the big stumbling blocks in reasoning that people have on this subject is you don't want to be the person that is derisive to the poor as a social class. It's real fun to make fun of rich people. It's actively funny. It's within the Overton window. It's safe. It's safe. Okay. Not so with poor people. It's considered unbecoming in the same way if you say well rich people exhibit xyz qualities because it's their fault people like that's right fuck them you say that about poor people a lot of people don't like that because it gives them very sad feelings inside we should not be bound by how we feel about things to be able to elucidate what is actually going on

so that in that third order we can help everyone including poor people now navigate difficulties better. Sure. The idea that we're going to pretend that poor people are sort of like protected against any kind of moral reasoning on our behalf, I think it just needs to be discarded right up front.

Well, let's get more specific with it than talking about abstract. Like, let's say the notion of access of healthy food and the preponderance of processed food in someone's cabinet that is poor. Sure. Much higher likelihood to have, cheaper food that is likely to be ultra processed that is likely to create a habit of

overconsumption less satiating food and as a result potentially lead to their obesity true or false true so then what's the retort for it highly processed convenient food is by no means the cheapest kind of food there is not by a long shot the cheapest kind of food there is by a long shot is largely unprocessed basic food like bulk bought rice, not even bulk bought, any kind of white rice, canned vegetables, reduced price, high fat meats, and other such products, canned beans are almost free. Calorie per calorie and nutritional content per nutritional content, they're undefeated. There is a diet through looking into it substantially.

What are those people not doing? Which people? The poor people. Oh boy. So that's its own thing, but just to finish the thought really quick. The real cheapest way to get the best nutritional food is to buy those kinds of essential basics and not convenient snack foods. Personal story time, not that this matters, just personal stories are mostly just like,

oh, I'm an end of one, just for the people that'll be like, this guy's rich, whatever. My parents were highly conscientious when we came to the United States. And the first time we had McDonald's was like two years. into being here, and it was considered an unbelievable treat. Yeah, same here. Same, right? That is, like, I remember being with my dad and my friend, and I wanted a burger really badly,

but I knew my dad would have to pay for a burger for my friend, and I was like, I'm not going to ask for it, because I'm embarrassed, I don't want him to pay for it. 100%. Yeah. So, like, that clashes substantially with the conventional narrative of, like, what burgers are cheap? Like, compared to what?

My parents and your parents were buying basics type of food. expect. Mine were for sure. I can't speak for you, but it seems like they were. And so that already puts a little bit of a situation because people like to envision that poor people are all relatively homogenous. That's absolutely not true. We can at least bifurcate them into two categories that we did earlier. Poor people of higher conscientiousness, poor people of lower conscientiousness. If you say that's not the only factor. It's hard to say that's the one dividing factor. It is probably by far the biggest dividing factor into how life, outcomes occur for almost everyone, short of intelligence.

So social experiments like the marshmallow experiment, the delayed gratification of it all, do you believe that that is a signal of conscientiousness? Jesus Christ. It took a little while. Yeah. Yeah. Why has the replication of it been a disaster? Well, that's the one done on like four-year-olds and shit, right?

Yeah. They had the kids come in and they tracked them for their lives to say, like, those who exhibited delayed gratification were able to have higher SAT scores, decreased crime rates, like basically what you're saying, that they were able to exhibit this one factor at this age and that, on the whole, projected a greater success in their life, what we deem success. And then when we try to replicate that, we, A, don't see that same pattern occur. And B, when we re-look at the past data, we see that the poorer kids who didn't have marshmallows just grabbed at the first marshmallow and then had lives that were in a position where they had less access to education, to proper discipline, to those things that perhaps poorer kids don't have access to, then have worse outcomes. So it was like, are we really looking at the delayed gratification or are we looking at a more systemic issue here? And that's an interesting point. The amount of evidence for trait conscientiousness impacting human lives throughout the lifespan is like a million times stronger than the marshmallow experiment, of which I'm not familiar

with any serious behavioral geneticists that cites research to that effect for how important conscientiousness is. Psychometricians, behavioral geneticists, if you look up trait conscientiousness, how to express itself in life, the evidence for its enormous power in guiding people through the lives is overwhelming. When do you measure it? Say it again? When do you measure it? And how do you measure it?

You can measure it in any point in a person's lifespan. The problem with measuring young children is that the correlation of whatever traits you have when you're very young to when you're old is actually quite low. And so like, you know, when people have like a four-year-old that's like he's the genius for his age, like a lot of times that just ends up being quite regular later, he just got there early. But you can measure conscientiousness through a variety of behaviors in an ethnographic context. You just watch people who do what they do and take very diligent notes. You can do it in an anthropological context.

You can do it in a cultural context, studying different cultures. You can do it with a variety of validated tests like the Big Five personality, the ocean scale. The ocean scale is probably the most common one. And you can administer various tests of that nature to people of very many age ranges and situations. And they all give you a hint to what's going on. But on aggregate, they paint a very, very similar picture overall. So it's not the fact that there's a correlation between that trait and something else societally in their lives that's going well.

It's both, but there's a causal effect as well because conscientious people over time make different choices, highly conscientious people make different choices of lower conscientious people. we also know that conscientiousness is profoundly genetic maybe 50% of conscientious behavior is accounted for entirely by the genes the rest of it is a little bit mysterious as to how it aggregates we're not entirely sure how that happens there seems to be no very dependable way to massively improve conscientiousness with any kind of top-down intervention that we have done before having uh uh peaceful communities that give you a decent degree of education probably has some effect on that but seemingly not as big of an effect on how we want. We also know that what your common home environment was, like how you were raised by your parents, it's almost no effect on your conscientiousness as an adult, if any effect whatsoever.

It's actually a little controversial to say almost no effect. Well, what about the effect of emotional regulation? If you have higher levels of what we call adverse childhood experiences, your emotional regulation is lower than that of someone who has less adverse children. Are those studies controlling for genetics? because almost how do you control for genetic twin and adoption studies

because i don't know between adoption literature a lot of that stuff completely disappears yeah i haven't looked at it specifically within the twin world but um knowing that you just said it's 50% genetic and 50% something else that we don't know sure what does that mean for the fact that those who are poor are more likely to be obese yeah so i can split it as it can simplify the matter two kind of different kinds of poor people one kind of poor person has all of this kind of social burden foisted upon them and they're doing their god damn best they're skrimping and saving they're thinking long term they're concerned about their health they're concerned about their body weight they're concerned about the choices of what kind of foods they're putting in their

bodies how it affects other things they're trying to raise their children in a very diligent way they don't spend excessively and so on and so forth like i said earlier those people don't tell to stay poor over the long term. Sometimes through a variety of unfortunate circumstances, they stay poor. Like someone who's incredibly conscientious, but is an incredibly financially burdensome medical condition who continues to stay poor and conscientious,

which is a tragedy, obviously. But there is another kind of poor person who is also poor, but exhibit very low trait conscientiousness, which means they just have a one day, one minute at a time what I feel like doing massive bias in their thinking and their choice structure. The emotional regulation.

of it. Sure. The emotional regulation presupposes there is a desire to regulate emotion. There are two ways emotional dysregulation can present itself. One, I mean, the ability, whether or not they want is a different thing. But conscientiousness speaks to wants. People who are conscientious, but have, let's say, profound attention deficit disorder, know they need to be making better choices. Desperately pray to God they can make better choices. but just keep getting off track because they can't maintain their attention and have a high degree of impulsivity.

People have low-trade conscientiousness don't care about making good choices nearly as much as they care about what's going to be fun and pleasurable for me to do now. And it's not even a value judgment. Fuck it, Yolo's a way of life, bro. And it's a decent way of life, but it's going to lead to different outcomes.

So if I am a poor person in the United States of a high degree of trait conscientiousness, I can easily make a variety of choices that will entirely prevent me from becoming obese in many circumstances. There's another component to this, which I'm excising for now, about food drive, which is also mostly genetic, which is critical to this discussion. I'll leave that for just a little later. If you are poor and someone tells you, well, I don't expect you to be fit because it's impossible for you and you have high trade conscientiousness and you've thought this through it for like 15 minutes, you're going to be like, planet fitness costs $10 a month. It's also irrelevant to go to a gym because you could do body weight exercises

and have a high degree of physical activity for free anywhere. Any food you eat, you could just eat less of and become however much body weight you want. And if you're struggling with hunger, you can buy less palatable, actually more expensive foods and buy basic beans and rice like Abuela raised you to eat. And all of a sudden, like, you just don't overeat that

because it's just not that good. We've seen that one of the sole explanatory factors for the rise in obesity is the ubiquity of high palatability foods everywhere super cheap. If you don't access those, It saves you money and you become more fit. So the actual impediments to achieving fitness and health to poor people essentially almost don't exist.

If you have treat conscientiousness very highly, if you have low trade conscientiousness, it doesn't matter if you're rich or poor because you're just going to yolo the shit. You, whatever you feel like eating, that's what goes in. And McDonald's just tastes better. Now, you're not getting spaghetti steak and shrimp because you're not a rich motherfucker. but you can afford very high palatibility foods, you know, chips and soda and ice cream. That's all very affordable to you and that's what you want.

And if people say, like, what about your fitness and health? Generally, your opinion is like, eh? And that's a totally fine opinion, but it's going to lead to some kind of outcomes. If you're ultra wealthy, you're in low conscientiousness, there's a high probability you're going to end up exactly as fat as someone who is poor and low conscientious. There was a study that came out about 10 years ago, studied food deserts. I don't like that term.

Highly insults people have actually dealt with real food insecurity. You're a Soviet Union in 1988. That's a fucking food desert, right? And they took a look at the data and they said that people who had vehicles, access to vehicles to leave the food desert to go to mega conglomerate grocery stores

became and were fatter than the people that didn't because they had the same low conscientiousness and not a distinct desire to be fit and healthy and lean. So when they went to the bigger mega grocery stores, they just got even better versions of the same fun snacks that they had slightly less access to inside the food deserts. So a person's individual proclivity of how they want to eat and what they want to put in their bodies, whether or not or to what degree they care about it is something that's not discussed much in the medical community. Because again, like, first of all, what are you going to do about it? Telling low conscientious people, they have to care about their body weight and their health and think forward, it's usually very ineffective.

it's insanely pedantic and paternalistic, and doctors usually have a very realistic approach. I'm going to try to help you in the way that I can. And if I tell you to eat healthy and you don't listen to me, we're going to medications is just the only thing I can do. So when you take a look at the two sort of very artificial groupings of poor people, if you have high conscientiousness and you're poor, all of the systemic factors keeping you obese seem to disappear almost entirely.

and if you are of low conscientiousness, whether you're rich or poor, and you have a high food drive, you're going to be obese 99 times out of 100. Eliminating highs and lows, 50th percentile people, they're the ones we're talking about when we're talking about generalizations.

So why are we talking about high conscientiousness versus low? Yeah, because... Let's talk about middle where the majority of people live. Yeah, yeah, because... Within one standard deviation. totally that's a great question um on average on average poor people tend to exhibit lower trade conscientiousness than richer people which could be due to social factors maybe as you said maybe uh this social factors are definitely a component of that but we know that genetic factors are a massive component of that as well

and whether or not they're social or genetic the conscientiousness is such a huge effector variable for everything else that that's kind of where the rubber meets the road so are you saying we need to target the conscientiousness of people in order to actually make change, not actually the food deserts, not what they're eating, the trait is what we need to figure out ways to impact. Is that the takeaway of you? No.

I think that's a fine idea. My contention is that if we target food deserts, if we target big evil food companies, we are not targeting the core onus of why obesity is higher and poor people. And the reason it's higher and poor people is a two-factor situation. This really explains, I think,

probably 80 plus percent of the variance. This is your theory. Hypothesis. Yeah, theory is a gravitation, evolution, et cetera. Much lower than theory. Right. I say theory in the non-scientific way. Yes.

Stop doing that. Yes. So the biggest determinants of your body weight and proclivity to obesity in the modern world is going to be a two-factor system. Your trait conscientiousness degree of that and your degree of food drive how much do you like food how much do you like to

eat how big of a deal is tasty food to you you no doubt have some friends that like they'll eat three and a half chips and they're like that's pretty good do they just sit there you're like the fuck i get into some chips i ate the whole bag food is amazing not everyone is like that right so if you have someone is a relatively low trait conscientiousness and they have a high degree of food drive, even if they're poor, they can still afford to be grotesquely obese, no problem. In the modern context, back in the day, that was not the case. If you have someone who is wealthy and has any given food drive, they definitely have more of an arsenal to shoot.

They can buy foods that are more filling, but are still tasty, like very Trader Joe's Whole Foods type of shit, that definitely has an effect, but they have to have some impetus to go buy Also pharmaceuticals? Because access of pharmaceuticals, especially these days, is a big difference. Just recently, for sure, just recently. Because, like, just two years ago, we just no one knew about a Zempec and no one even used it. Well, bariatric surgery existed. Totally, yeah, very extreme situations.

Again, most people, people of low conscientiousness usually are not interested in bariatric surgery because they're like, why how would I go do that? It doesn't make sense to them why you would do that because they don't seem to have. Again, we're talking about low conscientious versus the average. Correct. So again, on average, you have many more, a larger fraction of low conscientious of people that are poor than are rich. But the reason for why they're there, we don't yet know.

We know some of it, but we don't even need to postulate that because we have this thing of poverty causes obesity. That's the notion. Actually, a combination of high food drive and low conscientious cause obesity. Food drive. And it just so happens that people who are less wealthy, on average, also have lower trait conscientious. It's like the situation with vitamin D,

that those who have lower vitamin D levels have higher rates of certain illnesses, but then supplementing the vitamin D past the norm doesn't actually reduce the outcomes of those diseases. So much in the same way, when we talk about food drive, and you're talking about someone, as that being one of the two variables

that decide whether or not someone is obese, food drive is so impacted by social situations. One, if you're depressed, which if you're poorer, there's a chance that you're not getting help for your mental health situations because we don't have great access to that in America. If you're poor, you have worse likelihood of developing adverse childhood events that lead to mental health conditions. you are likely to have been targeted by big food companies in their advertising, which has been proven through research for addictive products like ultra-processed foods,

cigarette companies will specifically target their advertisements based on zip code, based on... Yeah, that's curious. I have a reason for why those people like those things better. Right. They buy them more. Correct. And that could be an education component. That could be a genetic component.

It's probably a multifactorial component. But why I find that interesting is because once those people are hooked on the product in a way where not that that food is addictive, and yes, it's true, it is addictive. And once you consume ultra-processed foods, you're constantly hungry, not satiated, you're craving all that stuff. But also, once you become obese, your epigenetics change of the fat cells. There was actually a recent study that came out. Eric Topal shared it on Twitter where, again, in mice, so I have to give that prerequisite.

22% genetic similarity to humans, so you can extrapolate. But still, I generally don't like jumping from mice to humans, but it is not illogical to see how the creation of fat cells for storage then can impact your behavior as years go on and the difficulty of escaping from those circumstances. So if you're a child that is born in an area that's poorer, these are the things that are likely to happen and they're not going to happen in every circumstance. worse education, more targeting by big food companies, worse social situation from a mental health component, high likelihood of being fed ultra-processed foods by parents, which then raise your risk

of being obese, then sets you up as an adult to regain that weight, even if you try and lose it, in a much easier way than someone who never had that issue that grew up wealthy. And then you're saying here that the only reason is because of the trait conscientiousness? Definitely not. I was explicit, but it was not the only reason. The food drive and the trade. They probably account for, I think, something like 80% of the variance. Over what we just said.

Yeah, so all the other stuff you mentioned is insanely influenced by trade conscientious. This is the baseline variable. The reason that people have, let's say, a more crime-ridden environment is because more people around are low conscientiousness. The tie between conscientiousness is criminality is insanely high correlation. So some of those same people are more likely to be criminally. prone. They're less likely to take care of their communities, leaving trash everywhere. They're more likely to make rapid choices based on desire and thus make you next to them the proxy target of big food advertisement. Big food didn't try to target poor people just because. You'd much rather target rich people with every product you sell because they have more money to spend. Curious why they would target the poor because there are some large fraction of them that are low conscientious to begin with that want these sorts of things. They are attractors for them, and they are the progenitors of many of

these bad circumstance. Trauma doesn't come from the ether. Trauma comes from people being nasty around you. Most nastiness in humans is because people have a high degree of impulsivity and just kind of do what they want. That is the same variable of low conscientiousness, basically in some large component, not totally, describing why things are the way they are with very poor communities, let's say in the United States? I think the difference in our hypothesis is that I see how you've gotten to see such a strong correlation

between low conscientiousness and outcomes in obesity. Causation. That's what I was going to get to. I see the very strong correlation that exists there, but at the same time, I see the very strong correlation as well as poor education,

difficult circumstances, all those variables that are also very strongly correlated. And I want to know how you just, jump to the causation without having a trial that impacts the trait and then seeing a better outcome. When you said that that trait can't really be changed. Yeah. Behavioral genetics, 200 adoption studies, genealogy, heritability studies that show that your genetics is profoundly

important as to how your life lays out in front of you. Everything else becomes usually secondary, it is extremely, extremely different from the norm, which definitely explains some of the variation with really nasty growing up circumstances, but not as much as many people would think. So if you ever dip into the behavioral genetics literature, and I encourage everyone listening to give it a shout, don't expect to be very cheery at the end of that dive. It's a real thing, man. It's a real thing. I certainly believe it to be a real thing at the extremes, at the high.

and lows. But I think when you look at 75% of the population, I can't imagine it being a causative factor to the degree that another random variable is. I gotcha. So I'll cite a couple of offhand random studies just for illustri of purposes. There's at least one study that past the age of about 12 or 13 your common home environment where you grew up has almost no effect on your eating habits because they did it with twin and adoption research

and they found out that if you came from a genetic stock of people that were prone to obesity or prone to making food choices that were more snacky junky kinds of foods If you were adopted into a home that gave you healthy foods, as a child child, up until teenage years, you ate what mom and dad made you. Healthy food, the whole thing. Then as soon as teenage years hit, you were able to make your own food choices, you veer so far into the average predictive of what your parents used to like that the degree of influence of your parents, adoptive parents, healthy eating instructions are almost undetectable.

Insanely rigorous research keeps coming up over and over again. any parents who have had children listening to the show, if you've had one child, you can attest to the fact of how great of a parent you were and how your effects made them who they were. As soon as you have child number two, you realize, holy shit,

we're shooting in the dark. Kids kind of become sort of whatever the hell they were supposed to become, and we have barely any effect. And anyone who thinks they have a large degree of effect on a teenager's, I don't know, insert joke here as large degree of delusion. The conventional wisdom on how education works

and how upbringing works, cannot possibly survive the rigorous data that shows that, for example, as I stated just now, food choice proclivity is almost nothing to do with a common home environment. After age 12. Correct.

And what about before it? Before it, it has a ton to do because you don't make the choices that you have. Like they put stuff on your plate and you eat it. And don't you believe that if you're set up before the age of 12 with bad habits that potentially create a childhood obesity, that you're going to have worse outcomes as you get older?

yeah for sure so then how are you saying that those social impacts are not equally as causative as the trait because when you look at the behavioral genetic data the social outcomes at the extremes can absolutely have an effect but most of what you think are the social outcomes is literally just the expression of people's genetic proclivities over and over mom and dad had the same ones you have the same ones. And if you try to get kids to eat hyper-palatable food all the time when they're younger, it definitely affects them when they're older, on the margins, 100%. But it doesn't affect their proclivity to make the same choices when they grow up. They're going to start eating healthy and thinking of the future as soon as they become teenagers, just like their actual mom and dad

did. And then they're going to have extra adiposity and struggle with it. However, unless you become profoundly obese as a child, childhood overweightness generally resolves itself as teens mature unto adults because unless you continue on the path of egregious overeating, more or less you can grow out of considerable chubbiness as you get older. I would like to see the date. Sure. Sure. How many like kids that are obese and what their rates into adulthood are. Sure. Sure. Do you know what they are? Not offhand. No. But it's things that happen to childhood can affect you long term, but don't seem to affect you long term nearly as much as people would think because your genetics become more and more an effector variable that's better and better

detected as you get older. In deciding causation, right, we think about changing a variable, randomizing it, and seeing what happens. If I could wave a magic wand right now and stop food companies from advertising to children, hyper-processed foods, especially in poorer areas. If I create access in food deserts, I know you don't like the term, but in areas where there's less fruits, vegetables for sale, and I sell more of those foods, less of the ultra-processed foods, even through an authoritative method, if I greatly improve mental health

support, maybe even medication in poorer areas. What's the mental health thing have to do with it? The mental health thing is that some people overeat as a way of coping through difficult moments. Because they have high food drive and that's a very happy thing for them to do. That's profoundly genetic. Many people in their most stressful time cannot eat. Sure. But it still doesn't change the fact that when they're sad they eat.

And if they're more likely to be sad in an area where they can get help for a mental health condition. I think these people also eat when they're happy. Celebratory eating is a cultural universal. It is. but I'm talking about the poorer outcomes where there's worse social outcomes and there's worse mental health support. What I'm saying is people with a high food drive

don't need any stress to eat more. They don't need any less stress. I don't like doing the hires or lows because that's not representative of the average. We're not talking about the average. We're talking distinctly about highs and lows because we're talking about poverty versus wealth and its effects on obesity

is a conversation exclusively of highs and lows. Because in the average, actually you can't disaggregate anything and who knows what's going on. Yeah, I'm saying in the average human, not, let's say you don't know and you're blinded to what people's poverty level is, you have to create a graph of what the average is. Sure. So you're seeing a lower degree of mental health on average causes people to become more obese.

Yeah, I think it's a factor. Is that, is that, I think it's a correlated factor. Okay. Is there like a thing we're like, well, ACEs. That's like the emotional regulation of it all correlates very strongly with people who have, issues of crime, issues of overeating, higher rates of blood pressure elevations. So those variables are there. I don't know about the twin studies because I've never looked at those. But my point was that if you wave a magic wand and you fix all those issues that I discussed, you don't

think there will be a significant improvement in obesity and poor areas? I think the improvement in nearly all factors would be very impressive and hugely helpful. locally, not systemically, because you have all sorts of really nasty side effects like drug dealers who deal in food and not actual drugs because now tasty food is illegal. Well, I didn't say make it illegal.

I said reduce and improve education. How do you reduce it if you don't make it illegal? You limit targeted marketing. Okay. Because that's so influential and that's outside of our control. There's ways that food companies change what we eat

without ever us even realizing that they're doing it. it's the invisible hand. Yeah. So I guess changing government policy. Food, food companies wouldn't be, people wouldn't know as much

about tasty junk food because food companies don't advertise them. So you'll have people who take advantage of that and let's say in the ghetto and bring two young children for sale healthy treats, they've, unhealthy treats they've never seen. And those kids are like, well,

what is that? Like, cheese it. You ever had cheese? I'm sure that'll happen. It'll happen because people want the food. What will happen to the number? Yeah, I think it'll go down. I think these, if they magic wand it, it'll be helpful for sure.

Here's my contention. There are a huge fraction of people, usually on the political left or just moderate, reasonable people who have been educated in the United States or the Western world, who believe that these variables of social effect, food companies, et cetera, are if not only, the only variables that very close to the only, the predominant variables. They expect the magic wand of external social factors to be waived and fix almost the whole problem, if not the whole problem entirely. What you're going to get is almost an inversion of that reality. Well, you'll get like a very serious improvement, 5, 10, 15, 20% of improvement in the problem. You'll have like 80% of the problem still left over and be wondering why, since we have these amazing educational programs, these amazing programs of reducing food advertising, health, mental health enhancements, so on and so forth, that some people are still demographically much more likely to be obese than others. It is because we ignored the two most primary causative variables,

which is conscientiousness and food drive. If you have really quick, if you have low food drive, it doesn't matter how conscientious you are or not, you're probably not going to be overweight because like food just not as big of a deal. If you are, have a very high food driving or very wealthy, you can deploy quite a bit of technologies and personal chefs and all that stuff, you'll almost certainly be significantly more overweight than otherwise, but maybe less so. If you have very high food drive and you have a low degree of conscientiousness, you're going to be very, very, very overweight. And all of the sociological variables in the world cannot help you to a huge extent. They can help you to a moderate extent. We're going to have so much

left on the table. They're going to be wondering why. So what I'm proposing, this is why I'm so Yeah, I'm passionate about the subject is I like to take holistic approaches. I like to understand the landscape of the entire issue we're dealing with before going and rendering very, very confident conclusions. For example, if you look at the British public schooling system, there's some public schools that are not so great, I guess, and some public schools that are just unbelievable. And the recent, this is quoting Robert Plowman's work, behavioral geneticist. behavioral genetic analysis of childhood success in school and after, especially after school, has the quality of schooling, quote, unquote, by ranked school systems in the United Kingdom that you received has almost no predictive effect on how successfully it become.

And when you see that, and this is insanely rigorous data, what do you have to shake off the page to make sense of that? Because when I read that for the first time, I was like, I almost stopped the car. It was an audiobook. And I was like, the fuck? How? Like, it was supposed to be a thing that you inject education into people, and they just get better.

And all of a sudden, when gradations of public schools explain almost no variance for outcomes after, and there's programs where they rotated kids to different schools, all lots of variation, it has almost no effect. If you knew behavioral genetics and it's aggregate before that, you could have been like, I could have told you that. And then you would have been like, okay, we should have predicted this wasn't going to be a big deal. How do we really address these issues and understand what is the realism with which we can approach the situation? If you didn't know about behavioral genetics, you would have

been like, do we need tons of funding for all of these programs? Maybe that's a good thing, but then you would have expected it to work. And when it worked on the margins, but not in its entirety, you would have had to contend with the fact that we got, I think we severely misunderstood the problem. A quick analogy just for folks who are listening. If you are under the guys, under the myth that genetics are not the biggest factor in athletic performance, you can take a scrawny little Jewish kid and try to get him into every single soccer camp in the world. I'm a billionaire. My kid's going to learn soccer from like the Brazilian national team themselves, day one.

You poured millions of dollars into your kid, and he's like 16 years old. He's the worst person on his non-select soccer team, and he's like, I want to play the violin. And you're like, the fuck, I thought I could poor athletic talent into you. And any sport scientist, to quote, paraphrase Jordan Peterson, worth their salt. It's a hilariously Canadian expression, would say, like, that's not how that works. Sports science is about identifying talent and then improving on the margins, sort of cultivating it. If you don't have the talent, you ain't doing a whole lot. Now, you can get better.

It's a similar thing to the poverty, obesity thing. If we addressed all of the sort of endemic issues that you were talking about, the systemic ones, external, social, cultural ones, we would get some decent traction. You coach a kid in soccer with the Brazilian national team his whole life. He's going to be pretty goddamn good at soccer, but he ain't going to the Olympics. No way unless he has mega, mega talent. The same is true about poverty and obesity and those relationships where if we don't address the food noise, which luckily pharmaceutical companies are addressing now with Ozempic,

which I think one of the best things we can do is make anorectic drugs like Ozempic and terseptide, et cetera, ubiquitously cheap and available. to everyone that needs them. That's going to make a big hit. Why? Because it addresses directly the variable of food drive. Trade conscientiousness remains. There is no drug you can take that improves it, unfortunately.

And it's going to remain this kind of sand grain inside that makes the pearl. It's a constant nuisance that will constantly be there. And we can have a lot of sociological, oh, we're just not doing enough. You know, education didn't work that well. We need more education. To your point earlier, like vitamin D, once you get enough of it, 10 times the dose is technically toxic over the long term. Sure, shit doesn't help.

So we have to understand the entire topography, the landscape of what we're dealing with and have to accept straight up that many of the core, most explanatory reasons for why poverty and obesity correlate with each other are outside of our ability to have traction on them in the modern timeline. And going from there, we should make

all of the changes that you recommend, which I'm absolutely 100% on board, depending on how they're executed, of course. That all stuff matters, but it's going to matter a lot less than many people think. I can't speak for you and tell you how much you think it's going to matter,

but because of what we know about behavioral genetics and how causality works in this case, it's going to matter substantially less than you think. And if anything else, it's disheartening. You did all this stuff, and then what happened? Almost nothing.

I think that's the only point we disagree on. I think the trait matter of it all, the food drive of it all, you created this 80-20 guesstimation formula. I can't even argue against it because I don't have the evidence to argue against it. And I don't think that you would even fight if someone said it's 70-30.

No, sure, no problem. Because it's almost an arbitrary number because we don't have solid. Exactly, yeah. But I do believe that these traits matter. The way that I think about it as a practical clinician, because I'm not a researcher,

is you hear that we can change the 20% with that magic wand that I was talking about and you say, that's not the 80% that is really the issue. And I view it as 20% decrease in obesity rates gets us under the average person in America being obese. That's a monster win for me. Because if we're, let's say,

at 60% obesity in the United States, if we'd get 20% drop off where 40, we're less than the majority. Yeah, the way I'm contextualizing it, it's going to be 20% of 60%. so it's going to be whatever fraction that ends up being... I don't know what the exact number is.

Sam, can I actually look up what percent of the United States is obesity? No, no, no, that's not my contention. I'm saying that if obesity is the problem and you solve 20% of it, you don't get an absolute 20% reduction. You get a relative 20% reduction. So in any case, like,

I really, I love that point. I think the, I'm looking at it from a little bit of a Sowellian pessimistic take of, well, geez, like, we're not even addressing the two biggest factors in the room. And it's totally fine to address all these other factors. Well, we are now. Well, I'm sorry. Yeah. As a society or whatever. And also just to put in the perspective from like the bariatric surgery side of things, which has been ongoing for 30 years plus more than

the GLP ones, the reason bariatric surgery works is partially because how it impacts your food drive. Oh, yes, almost entirely why it works that way. So this is not new medicine, to impact food drive. This has been going on since before I started practicing medicine. Yeah. And that's number one. Number two, medicine usually practices on the fringes. Yeah.

Like when we talk about vaccinating kids and we talk about saving hundreds of lives, someone might look at that and say, I don't find it worthwhile to vaccinate kids to save hundreds of lives. Sure. But we do, and science does. So yes, there's very little control

that we have of ultimate human outcomes because controlling one, two, three, four variables in the grand scheme of life is usually ridiculous in thinking you control the ultimate outcome. Yeah. Which is why I don't like protocols that say like, oh, if you ice bath,

you can create X, Y, and Z. I'm like, come on, man, one variable, especially such a small variable, is not going to have some meaningful, substantial change that we should give it this much air. Sure. But those issues, to me,

that if we can change those issues, A, we get some benefit, even if it's not the majority of the benefit. B, the obesity change isn't the only benefit that we get when we change those things. If we change education, if we change their ability to... What do you mean by education? I'm curious. That one I have a lot of... Okay, when someone walks in to one of my men on the street interviews,

and I ask them a question of, like, what nutrient is most prevalent in your banana? and they say protein, the odds are that they are from a worse education background from a health literacy standpoint is higher. Fair to say? That happens very often in lower economic schools, education systems, because there's not as much motivation to learn about those things. So the sales of a 64-ounce slurpee is much higher in that area

than it is in Greenwich, Connecticut, some really wealthy area. why partially because of education nutrition nutritional education is a perfect example of a variable that is talked about as a preeminent variable

here's one of my beefs with this coming up through the educational system in all of these fields you're not really taught that we were never taught that food drive was a thing that was largely genetically

correlated just never talked about we were never taught about conscientiousness we were taught about things like nutritional education empowerment to make better nutritional choices

monetary limits I think we weren't taught about those things because we didn't know how to impact them when I learned about these things they were taught as a theoretical basis for why things happen

whether or not you can impact something is very different than theoretically does it caused by something else and so I think the reason that they theoretically were not taught is because most people in the end of the field didn't ask the question

because most people in those fields are intellectually biased to the political left to begin with and do not to like to look to genetics and deep social forces outside of our control. Why? Why do you think they do? Because it makes them very sad

about the state of affairs and it disempowers them. They believe in human malleability. They believe that no one can be blamed for anything, that it's social forces externally all the way up and down and those are the, if not the only, the by far predominant reasons

why people end up different is because of social forces. That is like... But don't you think they always... Like, barring the extremes, most people would say that it's a mix of nature and nurture. I'm not talking about most people.

I'm talking about the educational establishment. You don't think they would say that it's a mix? No, no, it's... You can lose your job for saying it's a mix. If I was still working at the university, I would never give this interview. Because saying that poor people on average

have lower conscientiousnesses. I'm still worried about this going out. Holy fuck, that's insulting. If you're nuanced, then you're smart. You can understand how it's both real and not insulting. But if you're anything else and if you're very politically motivated, it's going to be a nuclear bomb.

You're blaming people for their problems. Even though in their private life, everyone knows people. I don't know if you're blaming. I think you're trying to establish a cause for why something has developed. I don't think you're necessarily putting blame on an individual.

Whether that person is conscientious, especially as you put it genetically, you're almost not blaming them. You're almost dissolving of the blame. That's a very interesting way to look at it. But aren't you? Is that fair? Because you're saying genetically you have this predisposition to this trait, therefore it's not up to you.

I think the concept of blame is one that the longer you look at it, the more it falls apart anyway. I don't like to deal in blame. I don't even know what that means. I like to deal in causality instead of blame. Blame is like an emotion you have inside

from ancestral times when the police and court system were not there to enforce things. And by blaming someone, you could paint them in a negative light and interact with them. I think we're going to get into this, no matter what. Do you believe in free will? No.

Oh, cool. And I think that, yeah, sure. But I think the concept of free will is preposterous on its face because people will say, well, what about quantum mechanics and randomness? Because that's random will. It's still not free will.

so I don't think there is a space for free will as most people understand it in a modern intellectual landscape but at the same time in your brain you have a machine that decides what you're going to think which is out of your control entirely and you have a part of that machine which reviews all the contents of your mind

and decides on aggregate am I going to make this decision that I just thought of or not and so the combination of having self-awareness and an ability to take all the information you know and aggregate it to not just my recent proclivity but also everything else I know certainly makes a system that acts as if it has free will but you really lends down into it it's not free at all it's entirely mechanistic so what would you say people watching this

that you're afraid of that they'll say about you I don't give a fuck that's well no but you're saying that you're worried about it going out what are you worried about um or why would you get fired yeah Mike's a Nazi come on for real no I'm serious. Check your comments. Check them now. But in reality, you think they would call you a Nazi? Yes. And why would they call you a Nazi? Because the Nazis took the idea that people had genetic differences that impacted the behavior and decided the end run best way to deal with that was to kill millions.

I think there's a really big problem with the kill millions part. Do I have to answer directly? Yes. Isretel. That'd be a fun Nazi name. I am a politically, very closely lined with libertarians. I'm a secular humanist. And so I think any time a complex human being dies, it is an unmitigated tragedy. I think that killing people and putting them into camps is abysmal.

But you can reason yourself through sociological effects only into the same thing. Evidence Joseph Stalin and Mao Zedong. They didn't believe genetics had any effect on anything. They believed it was all sociological. What did they do? Put people in the camps, toast them by the tens of millions. You can weaponize any philosophy.

Oh, yeah, sure. To any extreme. But if you're on one extreme or the other, you tend to weaponize the opposite. Yeah, but you're still the extremes. It's still weaponized. It just so happens that most of the community, the intellectual community in the United States,

the collegiate intellectual community, is wildly left-wing biased for a generation. And three generations now, the problem is getting, let's see, if it's a problem, that's getting worse. It's becoming more and more of a thing that the campuses are attracting more and more left-leaning people. And so when we're talking about looking at this from a grander landscape of what really is the cause and effect situation for why poor people tend

to be obese more on average, you're getting a very, very biased view for most of the academic establishments. They neither teach the basic theoretically of it. If you bring it up in class, you're a lambast that is like having borderline Nazi thoughts and the whole thing. If you bring up food drive, people will call you a Nazi? I don't understand how that happens. If you say food drive as mostly genetic, the right wingers will say you're excusing people's willpower thing. Okay. And the left wingers will, in some situations, be like, see, but then when you tie genetics to other factors, let's say racial factors, they're like, holy shit, Hitler reborn.

There are lots of people. The world has many beautiful things about it, there's many ugly things about it. And when you go, hey, this ugly stuff we should be looking at, there are lots of people that go, yeah, and there are lots of people that go, you son of a bitch, how dare you? And as intellectual, you know, every college campus says there for intellectual curiosity and freedom of speech and freedom of thought. And in the United States, almost none is or isn't. You and I could sit here and really get make fools of ourselves and get canceled by going,

what was Hitler right about? You know, he was right about a lot of shit, right? He was a fucking murderous animal who was wrong about the core tenets of his philosophy. But he had all the stuff that was correct. Order, social responsibility, personal responsibility, pride in the greatness of nation. It's a fucking awesome stuff. We don't need to jettison that. But people tend to feel so much more than they think in many regards that like soon as you bring up, oh, I'm doing free thought. I'm doing cost benefit analysis. Let's look at Churchill, Hitler, and Stalin and

see how their philosophies differ. You know, cost benefit pluses and minuses. That intellectual exercise is damn near forbidden on college campuses today. So the idea that we have free thought is largely been jettisoned. Like I went to the University of Michigan as an undergrad, a phenomenal institution. But damn near a propaganda machine when I went there, they're like trying to get you to believe a certain version of the world that felt really nice for people on the political left to believe. And so they jettisoned entirely, entire classes of introspection and trying to figure out what's going on, such as behavioral genetics, such as the true cultural differences and where they stem from, they had an idea that you could re-architect

external society to make any change that you want. That idea is wrong. It's always been wrong, but it's not completely wrong. It's partially correct. There's like, to your point earlier, it has some traction. You can change society and make people's lives better, even if they're the same people. But what you should expect out of that is a much more mixed picture. There's a lot of situations where you think the core variable of social, you pour tons of

social resources into it. It changes up to a point. Then it doesn't change anymore. And your answer is like, we just need more. social stuff and that is the wrong answer but if you're not willing to admit that this other thing even exists what the hell do you do afterwards that's a real curious situation yeah i guess the real research that i would like to see is what can we do to impact this trait like uh food drive and conscientiousness respectively yeah well food drive we kind of have some uh at least beginnings of

evidence for correct yeah but for conscientiousness as an example you could ask the same thing about intelligence. Probably the single most beneficial thing you can have. I always go back and forth in my head as to which one is more effectual conscientiousness or intelligence, but together they're the single biggest effector variables for everything else that happens in your life. If you are intelligent and conscientious above average, you're going to be doing some really interesting shit. If you are significantly below average in conscientiousness and intelligence, there's a high probability you're going to be in jail or highly unaccomplished and poor and making terrible decisions all the time. If you ask the question of how do we increase people's conscientiousness

and increase their intelligence, some of the answers are very straightforward. A cultural reinforcement of high conscientiousness. Like, hey, save your money. It's better to think of the future, things like that. But now the political left in some extremes is so insane that even trying to say that to people is considered paternalistic and entirely outside. Yeah, but there's the exact opposite happening on the right wing side where it's weaponized in the other direction. Totally. Equally as unhelpful. What I probably should have asked very early on in this conversation that I didn't is when you say that there is a genetic tie to the trait of conscientiousness, what is that gene that you're looking at, that you're describing? Because to me,

when we look at a trait that is something that we've sort of elucidated on tests, But what actual gene are you looking at? So it's almost certainly polygenic, which means hundreds, if not thousands, or more genes are responsible. This is true for intelligence. There's no intelligence gene. But there are lots of genes that have small, fractional mini percentages affect on intelligence. And in the aggregate, they make you much smarter or much less intelligent. Conscientious is the same.

You can track a lot of what conscientiousness is and how it acts by analogizing to child, development. Every single two-year-old is the least conscientious thing you'll ever meet in your life. They don't have the neural architecture to think of the future, mostly because they don't have a well-developed prefrontal cortex. Sure. So prefrontal cortical development is probably really, really tied causatively to conscientiousness. So if you had some wacky idea to genetically engineer people and you found a way through 150 genes to push the prefrontal cortex into more aggressive development, accounting for skull size, et cetera, then that would probably be something that would be a fruitful uh you know like it's if someone's um profoundly athletic and is an amazing sense of balance they probably have a larger more well integrated cerebellum because that is the seat for that kind of action so these are all just like the brain as a computer these are all computer properties of the brain thinking about traits like this historically has been problematic you mentioned the nazis yeah how they weapon that was a problematic thing what they did is just killed millions of people Right. Based off of that logic.

Sure. Again, their action is the issue. Yes. Self-esteem era of the 1990s elucidated that having high self-esteem was a big contributing trait that led to success from childhood. So we instituted participation trophies,

praising children even when they're failing, creating a higher level of narcissism that perhaps didn't exist before. And largely we've seen it as a failure of modern psychology, of trying to institute false self-sting. Very well-intentioned. And very from the political left.

Very well-intentioned. And frankly, I don't care which side it comes from. Just to keep in mind the idea that this is not the first political left thing to come up to the surface to where there's an orthodoxy that you're supposed to accept. Yeah, but there's a right-wing version of that in the past

that has happened. The right-wing people do not run the universities. There are two types of people. Okay, they run the government now. Do they? Literally every part of the government. Supreme Court, Congress, Senate. We won't get into something like 90% of actual government workers,

not accounting for police and military, politically on the left, just to keep that in the discussion. So the deep state on the extreme is an insane right-wing conspiracy, but in a more reasonable take, like, yes, most people who actually work in government of all levels are Democrats. And so when Republicans are in charge, they're dealing with a largely antagonistic workforce. Which is great because checks and balances are awesome.

When Democrats are in charge, then it's bad, right? The corollary has to hold true. I don't think that's necessarily true because I feel like the pendulum swings in both directions. But it doesn't in the actual running of the day-to-day government. Yeah, I don't know what is the actual predominance of government workers.

It's 90%. I'm curious. Yeah. But just to say like, Yeah, well, we did the well-intentioned self-esteem thing, right? Yes. I read a book by Roy Baumeister about the power of willpower. Have you looked at any of his work?

So there was a thought that it's not self-esteem. It's willpower. That's the thing. That if you have good willpower, you actually get better outcomes. And that's the one factor. We need to focus on boosting willpower. And there's little things that we can do to impact our willpower throughout the day, throughout our lives, et cetera, et cetera.

And that's also fallen out of favor because we've seen that artificially trying to change this trait doesn't really help. No, okay. So does it not help or does it not work? Like, is willpower enhancement actually not something we can gain traction on?

Or is it the fact that the people have substantially improved their willpower in a robust way that lasts and that doesn't still improve their lives? I think that we don't, we don't know which of the two it is, we just know on a clinical, practical sense, it doesn't. Yeah. So that comports back to the whole behavioral genetics thing.

There's only so much you can change for a person's expressive psychology with external factors, even from childhood, definitely in adulthood. So the idea that you can change someone's general ability to yield willpower, which we express as discipline, is curious. And the behavioral genetics literature would be like,

you probably can't make much of a difference. That's the thing is both intelligence and conscientiousness seem to be deeply genetic. And if we have a robust plan to genetically engineer anyone who wants it, now we got a real solution going. Short of that, we should do our very best in every regard that you expressed on providing social services, so on and so forth. We cannot expect miracle resolutions to many of these societal issues because, and I'll say it very plainly, it's dope to talk about neutral. education and it helps many people on the margins but when you try to educate someone who doesn't give a shit about what goes into their bodies who cares it doesn't matter and the reality is that many people like to engender ideas of who they're helping having met very few or none of the

people who are actually trying to help if you talk to a lot of people who are very substantially overweight, a humongous fraction of them. Sometimes in words, depending on the context, almost always an action, don't really approximately give a fuck to do anything about it. Many of them do. And those are the people who you're going to be able to help a lot. But a lot of them don't. And the thing that that revelation that you get from behavioral genetics and sort of multifactorial analysis that reveals like some people just kind of want to do this stuff and they like eating junk, they're not going to be bothered by it

because there are hundreds of millions of them that exist in the world and tens of millions in the United States, at the extremes even, the optimism you have to have for your ability to change the situation has to be brought down to reality and your bandwidth for how to think about addressing the problem

has to expand to think, okay, we got people nutritionally much more educated. It helped a few percentage points. We thought nutritional education, as we were taught in school, was it maybe a third of the issue. But it had a 6% reductive effect, and we're at the saturation point for nutritional education. Where people can tell you, and here's been my experience, almost everyone who walks through the door at McDonald's and outcomes with a shaken burger, do you think that's healthy? Almost everyone will go, no, hell no, what?

You give people a bag of chips or a green apple. which one's healthy? 90 some percent of every American is going to be like I said the son on the pocket this is a true question right? No, no, no, no. Legitimate question.

They're like, you're fucking with me. It's the apple. Duh. Well, if you ask that to Dr. Gondry, he would disagree with you. He says grapes are basically the same thing as Hershey's. So you know how like once you,

it's like the monk on top of the mountain, the simpleton and the monk agree? Gundry's that smart that he's come back around. Wow. Okay. You're giving him a lot of credit. Dr. Gundry, by the way. I'm so sorry I said Gundry.

How insulting. Do you want to do a cigarette break really quick to enhance our health? No, I want to live a shorter life. I almost broke my phone in half when I watched the cigarette clip, by the way. But I decided to smoke a cigarette instead because I care about my longevity. And something nicotinamide, something other, the British health study, you know the rest. Oh, man, that was painful. If we control food drive, does conscientiousness not matter for obesity?

Oh, man, I would like to agree with that. It won't matter nearly as much as it does now. So if you control completely food drive, so conscientiousness expresses itself in fun ways. You give people ubiquitous access to anorectic medications, let's say 7th gen in 2032. They're just ultra-hop. The better version, Ozempic for those lists.

The 10x better version. You still got to take the pill. And there are people who, even if it's a one-time genetic enhancer shot. You get the shot, your genes change, you're just going to be skinny with your genes. Some people aren't going to take the shot. Some of those people are just like,

hey, did you get to the treatment center to get your shot? They're like, nah. How many people, what is the correlation between conscientiousness and doctor's visits? Mike, it's real high. Some people just don't give a shit. You ever deal with people in the hospital setting

who haven't been to the doctor in living memory? Of course. So when your conscientiousness is low, short of us violating your civil liberties. Yeah, look, I have patients that are nihilistic that end up in my office for a variety of reasons and I can't really help them.

Right. Right. So, but the food drive thing is for all the folks with low conscientiousness that take the food drive medication and or get the shot or whatever, they're going to see enormous changes. However, even if you have relatively low food drive, junk food is still fun to eat.

and your ability to think of, because is this good for me or bad for me, if we get you back down to like normal food drive, you can still be substantially overweight, though not obese, because you just really like to snack. And someone's like, are you hungry? And you're like, not really, I'm just eating.

Well, like, bodily autonomy is. Huge deal. So, like, I box and that's terrible for me and I know it is and yet I do it. Yes. Yes, exactly. I have taken grotesque amount. of anabolic steroids and all the bad things

I talked about last time on this show. So it will have a huge effect. It won't have a hundred percent. It won't have 100 percent. Well, who's looking for 100 percent? I feel like with one variable controlled, you're not going to get 100 percent.

No, for sure, but you're going to get a lot because a food drive is absolutely the quintessential variable because if you... So if you're going to get a lot, why even talk about conscientiousness? It's not... You can't really change it, as you said.

Yet. Yet. If you control for the other variable that you talk about within the poor communities about food drive, it pretty much gets you almost all the way there.

Not a lot of the way there. A significant majority. Why talk about it? Yeah, easy. So you're going to have a situation in our magical mystery pretend world here where the difference in obesity rates between poor people and richer people

used to be, let's say, 10 imaginary units of obesity, and now there are two imaginary units of obesity, right? We made an 80% reduction in the difference between wealthier and poor people. We have addressed everything you suggested and everything I suggested, short of conscientiousness, food drive, medication, access to everything. Everyone's no longer experiencing stress and trauma, relatively same rates, so on and so forth. Like, look at Japan, for example. It's actually just not true to say that poor people in Japan experience more crime, stress,

and trauma than richer people, because there's just no statistical differentiation hardly between them. There's not really any crime and stress and drama anywhere in Japan relative to us, right? I have no idea. So, yeah, well, you could look at the statistical data, but if you go to Japan, all of a sudden, it seems like, okay, where are all the violent people? I'm going to Japan in a little bit, so I'm trying to bring violence to them. I'm kidding, Japanese people, please. All jokes.

So if you look at that situation in the future that we could have, we've reduced the problem an unbelievable amount, but differences still exist. You're going to have the temptation, especially with the, ideological bias of most of these institutions that we have that actually make these changes, like institute the regulations for food advertising, so on and the people behind them, and the people politically who voted in those people very well-meaning Americans who want the problem to be resolved. Because anything that's a difference between wealthier and poor people, including money itself, is kind of fucking gross, right?

Like, what the fuck? Like, just because you have less money, you should have, like, shittier health, that's fucked up. Like, we all want the difference to be zero. When the difference used to be 10 units and now is two, holy shit, two years. your point like what the that's it problem more or less solved no no but like we did it why do i still give a shit about consciousness here's why because when you have that smaller difference people are going to be like all right we're not doing enough on the regulation side we're not doing enough you can go too far that's your concern they have in almost every other regard that's just what

they do and um you know a suit is like you know the oppression olympic situation that's happened recently in politics, as soon as you could no longer statistically detect different levels of oppression among different genders and races in the United States, which probably was most of the case about the 1980s, depending on the literature you look, some really in 1970s, definitely in 1990s. In the 90s, you think like, dude, like overtly insanely like racist, homophobic, like in the old Alabama way people, they're just like a teeny, teeny tiny fraction and they can't possibly explain all these systemic differences and stuff. People went way overboard for 30 years trying to address these issues, not coming back to being like,

okay, what's the base reality here? So for the conscientiousness situation, if we cabashed every other variable, but we still have this 20%, which absolutely is much lower, but relative to someone who comes of age during that time and sees, like, big differences. You know what I mean?

Like, imagine someone from the year 1600 coming to America and you just give him a tour of New York City. And they're like, what's that person? Like, it's a poor person. Like, he's overweight and he has a cell phone in his hand. Like, right, that's what poor people are like, but it's real bad.

They're like, he has no place to sleep. Like, he has a place to sleep. It's warm. He's a gigantic color television. He has access to the internet. He gets essentially, like, functionally through the city, really, really good health care. Like, what's that mean?

Like, nobody really dies of infections anymore unless they, like, really untreated. All the diseases you know about don't exist anymore. And they're like, I don't understand why we even care about rich and poor. Everyone's rich. But to us growing up today, even small differences can seem quite stark.

And so what we'll do in the future then, if we don't account for conscientiousness being a relatively large variable, then we're going to have this thing where we've got to do all this other stuff. And the reality is none of that other stuff is going to work because it's completely saturated. We're going to be attacking a problem

from completely the wrong angle because we've never we've never sort of taken to task the crux of the issue. A quick offhand example. If you've had some relatives who you deal with, who you've had not so great relations with,

you think it's the way I'm speaking to them. it's the way they understand me. We have to ever come to Jesus talk. We have to really do. We have to do the therapy. And it turns out years later, like they have a psychological condition that's endemic and they have to be on drugs

and therapy for it, but you never addressed that because you didn't want to be like, hey, Uncle Bill, I think you're fucking crazy. Like crazy, crazy. I think you need pills because you were like, oh, that's not cool.

I'm not telling him that. You would have been like, you know what? I'm just not kind enough to bill. Next time I'm bringing an even bigger Christmas or Hanukkah present or whatever the fuck. And every year you bring a burger present, he's just the same kind of dick.

Now, it was better than when you didn't give him presents at all, but it hit a baseline. And you're like, what am I doing wrong? And the answer is nothing. That's just who Bill is. People with a very low conscientiousness can only be helped to a certain point.

They just make different choices. It's like trying to expect your toddler to be formal with greetings and go to school on time by himself. You're like, that's a kid. You can't expect him to do that. People with low trait conscientiousness are going to live their lives in different ways

and face a cacophony of problems that don't occur to people of high conscientious are problems that even exist for an adult. And if we don't have an understanding that that's a real thing that we should expect, we are going to spend a lot of time and resources that could have alternatively better spent in 50 other different ways

on that problem, and they're going to have no effect for generations. We've already done this with education in the United States. We've already done it with a ton of different factors. What I'm saying is, let's get a full understanding compassionately of the problem at hand, try to understand what fraction of what is accounted for by which variables definitely address the variables we can.

But then when people say, like, how come there's still room left over, I would like future universities to say, look, look, you can help people a lot externally, but a lot of it depends on the person themselves. And we haven't found a way to change that yet. And if you bright students of today have any great ideas about how enhanced trained conscientious of people, we need you to think that through. But so far, we've kept away from it, but we know it's a factor versus saying, why would you even care about that, you fucking Nazi?

And then all of a sudden, we're back to square one where we're like, we've deployed all these strategies. We need more strategies. Imagine we're to a point where trade conscientious isn't accounting for all the obesity differences. And you're like, we need more anorectic intervention through drugs. We're going to drive people so high in anorectic scale, regular people who don't have low conscientiousness and who could just say, you know, fuck snacks. I don't need any snacks. They're going to be like, the government's going to be like, here's the average dose of, you know, fusurals epic, we need you to take. They're going to be getting very low in body weight. They're going to be getting osteopenic. And you're going to say, like, well, more. They need more.

And you're like, no, no, no, no, we're actually having real nasty side effects from this now. The thing you're trying to change is a thing that can't be changed because you're not even looking at the right variable. It's like, how much more basketball training do I need to give you for you to be able to dunk? You're like, dude, I'm 5'3. There is no amount of training that's getting me to dunk. You're like, no, no, no, it's got to be something with the calf tendons. You need to go to Bulgarian basketball camp 24-7. You've just pissed away a child's life changing an unachievable goal.

You are worried about the future, trying to create perfect scenarios that perhaps don't exist. Because of some inevitably unchangeable. No, no, no, because in the future, that's the concern. It's not an issue now. You're saying, like, right now think about the social things, but, like, once you get the benefit of that, then don't think that you need to do more. I don't know any people that I've ever talked to who are genuinely concerned to

try to make social changes that think they're working on a 10 to 20% factor. Almost all of them think they're working on an 80% factor and they're not. So I think today is... Does that matter? Again, in the present, in the present. Yeah, oh, yeah. Because how the government has finite resources. And if you think you have a huge degree of traction

on a really big problem, then you're going to pour a lot of resources in that problem, and it's going to take resources away from other problems. Whereas if you realize, like, okay, we can pour some resources into this. And to be honest, we're doing pretty much as much as we can now and the rest is kind of not up to us. Then you go, okay, we're doing decent here. Let's switch to an alternate way of affecting other variables.

We don't have free money coming out of the ground. And if we start getting free money coming out, they're going, fuck it, spend money and everything. We'd just have people eat money at that point. You know what I mean? Why do you think that when the self-esteem movement came about and people labeled that as the trait to focus on, no one called them Nazis?

Well, it's the opposite of a Nazi ideology. A lot of conservative thinkers called them socialists and communists. When they said this self-esteem. No, yeah, yeah, you're going to make up a bunch of entitled assholes and pussies, you're going to pacify a whole generation. There was all sorts of nasty things said about that. But fundamentally, when you say, look, who's against people having more self-esteem?

Kind of nobody, you know? I mean, somehow, if you could really improve people self-esteem, people generally think that's a good thing. But if you say, like, look, like some people, the number one cause of the problems in their life is them and how they behave from a largely deeply cultural and genetic perspective. Like, their entire subsets of American society,

with nothing racial, by the way, uh, every race has subsets of their, of their, of their culture that is like yolo culture like live for today fuck fuck everything else like don't you think that matters you know whoa whoa we're not going to go judging people's cultures it seems nasty to judge people's activities it seems nasty to blame the victim and that's why you don't get as much push back about it and that's why i'm here embarrassing myself to push back on it for for reasons of again tradeoffs of what issues you attack because if you think something's really tractable and you have the money to spend and it's worthwhile

You fucking spend the money. If you think something's, ooh, not so tractable, we've already spent a lot of money. It's not seeming to have marginal effects at this point. You got to ask, because like, from a grander perspective, the kind of issues that affect the rest of the world make us look like spoiled fucking children. There are parts of Asia and Africa that are destitute.

They need our help. And being a humanist, I don't even fuck about borders or nations or any of that shit. It has huge value in other words. But we got to help real people. And when you're spending hundreds of millions of dollars into nutritional education where you now know that the returns on investment are teeny tiny and you could be sending hundreds of millions of dollars in development aid properly administered in Africa and South Asia,

oh my God. Like you have a hundred to one life-saving potential that you wouldn't do well in politics with that message. There's a reason I'm not in politics. You want there to talk about muscle. Can I tell you my take on it? Yes, I would love that. Because I don't want your thing to influence what I'm going to say.

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A box of fine wines, yes Uber Eats can definitely get you that Get almost, almost anything delivered with Uber Eats. Order now. Alcohol and select markets. Product availability may vary by Regency app for details. My thought about muscle is that right now, muscles talked about as a longevity organ. Because, like, for example, someone will get an invite to a podcast and they'll say, what's the most important organ?

And they'll say your thighs. Because if you have good thigh muscle, you could stay independent, you can go see. your friends, you can exercise, increase in muscle tissue, decreases rates of hip fractures and balance, and they'll point to all these things. And I think muscle is incredibly important. And there's even a protective factor in muscle from obesity and regaining weight after losing weight if you were once obese. But I think it's just another phase of excitement to talk about obesity in a new way. That's my thought. Yeah, I probably agree. Okay.

You said it all. All right, cool podcast. Wish all of them were this easy. No, but what's your thought or how does it differ from mine? So I think there are two components that in the real world are enormously, enormously effectual for health, long term, longevity, and a massive reduction in morbidity, even more than an increase in longevity. And that is the balance of muscle and fat that you have.

That's the more important one of them by a factor of like eight. or some shit like that. But muscle is also important. And so at any given body weight, if you have more muscle and less fat, you are profoundly more healthy in every measurable way. And if your body weight is also relatively lower,

you're also profoundly more healthy. So when we are seeing people who are, let's say, in their 50s, or something. Their blood works good. Health outcomes are good. No concern. A regular, and I don't want to ascribe any opinions to people, so this is all fantasy land nonsense, which is really should be the title of the podcast. Mike's a delusional idiot, comma, and a Nazi, in parentheses, Hitler himself reborn.

So when people in a traditional medical establishment, which I don't ascribe you to be in. I am. Yeah, but you're one of these modern thinking doctors. You don't even smoke cigarettes That's when taking patients. What are you doing? You know, Dr. Gundry said, and I'm becoming angry at various clips of Gundry in my head. So when people see 50, 55-year-olds in their office, regular health screening, and all the blood work is good,

they're like, sweet, have at it, you're great, see you next time. If I'm a person who's got a little periscope to the office and I see them, and I see that that person has a relatively low, amount of skeletal muscle mass and a high degree of relative atoposity. Relative body fat is higher. You know people that are like normal weight but kind of made of mush, skinny fat or whatever?

Like me right now. I've been looking at your body for quite some time. I haven't seen anything I've disliked yet. Well, thank you. No problem. For your objective measure. Okay, can we like stop the podcast and get it popping? Yes.

The cameras can stay on by the way. That's a different show, Mike. Oh, nice. I heard that's going well as well. Mine is also. Mostly feet. I digress. when I see that person

and if I'm that doctor and I'm not a medical doctor but if I'm like a consultant to the medical doctor like hey sports scientist what do you think I'd be like we got to try to talk to this person about resistance training consistently eating a diet of enough protein to make a difference and trying to get the balance of their fat and muscle

through whatever ways decrease in fat increase in muscle usually it's much more decrease in fat because muscle gain doesn't go as high as fat loss is capable of I want to see them next time in the office looking just thinking of older folks. You know like a Willem Defoe. Do you know who that is?

Of course. It doesn't matter what age he is. He's fucking lean. And he's kind of jacked. Not jacked. But he's like wiry. A person 55 years old of Willem Defoe's body composition to me is a person who is outside of crazy whatever drug habit or whoever the hell knows for real people in the real world

at just the value of their body composition as a predictive very, for future morbidity and mortality, I would say, look, if you're in really good health, but you have a high degree of adiposity or a low degree of muscle mass, even if you're of a healthy weight, you need to get to work on making your muscle mass higher and your fat mass lower

because that is going to have a huge effect on how your health is later. And so if I'm a consultant to medical doctors, I don't rest until every patient I see over the long term eventually comes back to the office with visible muscularity. and no grotesque aggregated atoposity, like massive spare tire, thighs, et cetera,

or if they flex their arm, there's some hard stuff in there versus just goop. Now, none of this is a personal judgment whatsoever. I actually don't value people more or less based on a jack or lean they are to any extent. I don't care at all. Most of the best people that I look up to in the world,

I don't even know what their body comp is. They don't care. But as far as an individual perspective, the more muscular you can be and the leaner you can be, especially the latter, but definitely the former, the healthier you will be long term.

And the strength of these variables as a factor variables is so massive that I don't want that doctor letting people out of his office with good blood work in their 50s who have very little muscle mass, but a lot of adiposity relatively and just be like, you're good to go.

I want that doctor, if it's in the scope of practice and polite conversation to them to be like, hey, you're doing good. Now your dexas scan, Has you doing just fine, the bones look strong, but you'll benefit really, really greatly if you do some resistance training.

Here are the resources for that. Here are the resources for diet to work with a registered dietitian to bring the body fat down and the muscularity up. And the person's going to be like, why? My blood works good. You're like, see, it's good now. But the thing that makes it good is largely how much fat and muscle you have

over years and years and years. That's my big contention. You're walking at this moment sitting oxymoron. How dare you? I've never been accused of, Guys, what word does that, what do you say? I'm not a moron and what oxyclean was a great product. Do you know why I say that?

I have my suspicions. We had this whole two-hour conversation. And the takeaway on your end, it seemed, was that the social issues require so much work but are not going to give you the majority of the benefit. Is that sum it up somewhat fairly from an obscure sideway? And then you want in the limited time we have in our offices

to change human behavior by telling them, hey, lift more, and you think that's gonna lead to actual human behavior change? When we look at recommendations of diet and exercise for weight loss, 95, 98% failure over the long term, talk about getting little reward

for the time spent. The thing you're talking about, which I agree with, by the way. Yeah, of course. It is the thing that actually yields the worst results. Yeah, I didn't claim it was going to save humanity. The other thing is, if you deal with highly conscientious people, as possible to have it effect. It sounds like you have a bias for conscientious people.

I do. Okay. Well, at least you said it. Yeah. Because you said you don't judge people based on their body mass, but you probably would judge them based on their conscientiousness. We could have a long philosophical discussion on what judging people actually means. I appraise everyone I ever meet. Okay.

Like, you know, I've been on dates before when a girl's like, are you? judging me? I'm like, absolutely. Are you the guy in the room that talks about what discrimination actually means? Yeah, hell yeah. Can you tell the audience? Oh, I'm not trying to cancel myself anytime soon. Discrimination is the ability to tell things apart. Yeah, Thomas Olin, my t-shirt, man, I can't do that. I read discrimination disparities and he did a great job talking about if you're discriminatory taste with wine or with your sexual partners. You will be a fine describer of wines. Yes, exactly. So basically, first, yeah, if you tell people of low conscientiousness to like, hey, lift weights and eat better, reduce your body fat, fucking who gives a shit. So people

are high conscientious, they'll have a better time of it and be able to do better. But this brings me to the next part of my talk where this kind of social effect is going to hit some people, but it requires so much effort in our modern food environment to constrain your adiposity, to increase your muscularity, that a lot of people just don't find it as something that manages to squeeze in in their schedule. And I think that if you have a situation

where you tell people, like really, doctors across America are really pushing resistance training, they're really pushing lowering adiposity, even relative adiposity, if BMI is not too high, you're going to have a substantial effect that's in that 10% of solving the problem, but that's like tens of millions of people

whose lives have been extensive. It's wonderful. Exactly like I think that your sociological stuff is wonderful. That's great. But you don't like it. No, I love it. I just think it's just not super powerful.

So I agree with total consistency. Given that your career is about the non-superpowerful thing. Really my career is about like sports science. It's a hobby. I work in the entertainment industry. Legitimately, sports is just entertainment. So that being the case, I think the next step, and this was described well in a review article recently written,

we need to really seriously consider the development of a non-angiogenic anabolic drug. So we've now have the modern anorectic drugs, the GLPs, GIPs, GIPs, glucagon, agonists that have allowed us to kick down to any body weight reasonably as we tolerate the drugs, anybody what you want, you just crank the dosage eventually

you get to that body weight. As long as you're just remotely interested in eating sort of the right things. Not necessarily the case. I'll debate you all day. It's not my take. Again, the bariatric surgeon said that once you're in the BMI's of 50 and 60, the GLP ones are not getting you

where you need to be, alone. And that's why multimodal, multi-modal therapy is now the forefront of the research, where it's both. Both what? Bariatric surgery with a GLP-1 after. Oh, sure, well, yeah, then you have like, also like an insane number of fat cells at that point

that are scream really loud, and they just can't dial up the dose enough to, so that's why I mentioned side effects. If you could mute the side effects and dial up the dose, you could get people in the five or six hundred pound range to weigh 100 pounds within a matter of years, but they're gonna look like skin bags or whatever, which I will say,

of men. I have to say this as much as possible. The skin removal techniques as an industry, surgical and non-surgical, are the trillion dollar question for modern medicine in the late 2020s, early 2030. So whoever the fuck is listening, hit me up. I'll invest in your company. JK, please, well, I don't know, feel free to give me a shot out. I don't know if I'll see the email, but it's a big deal, right? Because I'm picking all those drugs are helping so many people lose weight. And a lot of people think, like, I'm going to lose weight and I'm going to look like whatever, like the celebrity I like and they're like oh shit skin to just doesn't go away and so skin removal is a big big deal in the future but so maybe as bariatric surgery drops off because the latest study that came

out showed a 130% rise in glp1 prescriptions and a 30% drop off in bariatric surgeries so maybe as they have more time because when I ask the bariatric surgeon about that she said that they have spent their time where they're performing less bariatric surgery performing general surgery Interesting. Also, like, for sure. And also, like, as a very different thing from, like, developing medical techniques that are effective, if you're a very niche field of medicine, it's just not a huge environment with a lot of, like, a total part of the economy going into an total amount of thought,

going into how to resolve those problems. There's lots of people thinking about heart disease. Very few people thinking about, like, you know, austere monogenic conditions or like, there's three guys in the world that study your condition. I'm really sorry. Hopefully we'll get more AI about it in the future. But as literally tens of millions of people become candidates for skin removal surgery,

that side of plastics is going to be like exploding. Because it's like, oh my God, like anyone who figures out 10x cheaper and more effective, easily recoverable and aesthetically more pleasing skin removal technique, bro, bro, the medical companies that do the tech and the doctors that do best surgeries, huge. In any case, I digress.

I was going to say it's the exact opposite of what the future looks like for food companies. Well, boy, that's a whole, Other thing, we'll have to. Oh, I have a question, because I love your philosophic answers on these. Name one industry that benefits from societal, significant weight loss. That benefits from significant societal weight loss? Like, if we were to create, like, a better version of Zempic 10.0, that is better,

no side effects, no issues, and we can get everyone into a healthy weight, what industry benefits from that? The junk food industry. Benefits? Yeah, hugely. How does it benefit? Because now you can eat junk food and doesn't fucking matter. No, but you consume less junk food.

Yeah, less. You're not going to eat zero. And now you can eat tons of junk food. And as long as you get your protein and all the healthy foods in, you're not going to be excessive on calories because you fill up so fast. So now junk food becomes, junk food companies want you to believe that junk food can be part of a healthy balanced diet. They're completely correct for a small fraction of people that have very low food drive.

In the future, with modern in electric drugs being ubiquitous, everyone's going have low food drive and it's actually true to say like dude get a bag of Cheetos and people like well I don't know they're going to lead to no they're not have a bag of Cheetos you're fucking good no one ever got fat from a bag of Cheetos now hundreds of thousands of bag of Cheetos over the lifetime that's thing the junk food industry is going to adapt and make junk foods that are maybe some of the similar ones today they also maybe make ones that are slightly healthier or higher in protein so an industry that's going to i think absolutely blow up is the uh high protein healthy food but fun snacking industry you got a lot of people now they're losing weight

they're empowered by these beautiful new drugs, but they're like, I still kind of want to eat some fun foods, but I know some of the shit's not good for me, and these medicines have put me on the right path because there any way I can eat, like, potato chips that aren't going to fucking kill me, healthy junk food is just glazed with glory and profit, I think. With junk food in general, I don't think there's more so

than the current junk food that exists. Like, there's higher profit margins in that than what it's like now. In healthy junk food? Yeah, hell yeah, because more people are going to be. I just think right now the foods are so hyper-palatable and so addictive that whatever healthy junk food you have, there's no way someone's going to buy 10 bags of it. So I do have an interesting prediction.

There is not a real war, not a hot war, no shots exchanged. There is a war between hyper-palatable foods and minor anorectic medications. The response for foods development now is going to be like, okay, people are eating less with OZempic. How do we make our food so fucking tasty,

even with OZemPEC that they continue to eat in large quantities? It's a cool thing. Eventually, it's just going to make a lot of food really, really amazing. and really, really cheap and a lot more people who want to be just as lean as they like

eating those amazing cheap foods and moderation. But if in like 10 years you're not on a modernoreorectic drug and you're like the average food drive and you just eat sort of whatever shows up to your mouth, the probability that you're going to be obese is insanely high.

Same prediction it would have been in the 1950s. Like think about the 50s, right? Not a lot of hyper-palatable foods going around. Just regular people with normal appetites that today are 300 pounds were like 175 pounds back then. I'm going to be like, dude, in the 2020s, you're going to be fat.

Like, bullshit, no way. Like, food is going to be so good and so cheap, you have no idea. Fast forward, the 2020s are like, dude, you're right. I can't stop eating this shit. That trend is going to continue. So the Ozempic stuff haven't ended.

They're just another salvo in that fight of corporations bringing you pleasure. But ideally, the best corporations bring you all the pleasure with none of the side effects, which is why I think healthy foods that are super tasty, but are good for you and fill you up.

My God, imagine a bag of chips you could buy that was very nutritious, unbelievably delicious and was super super affordable you would just eat that regularly and because that company

continues to sell you chips and has nothing to apologize for and can advertise like you can make this part of your diet can you name one food like that right now oh I have a really good example Fair Life shakes the dairy based protein shakes

correct they are unbelievably delicious and really really nutritious is all right Are you sponsored by them? No, God, no. Fair Life, please, sponsor us. I love them. I love you.

I'll sing your praises. Dude, Fair Life's amazing. Yeah. There's lots of, like, cool chicken sausages they have now, but you can get at the store and grill up that are incredible macro, super high protein, low fat, and they're ultra delicious and super healthy. So. Heme iron. Say that again? Heme iron.

What's that? Dangerous component of meat-based foods. Oh, yeah, sure. Yeah. Well, let's make a sausage together. That's like the prime drink or the, what's that lunchly of sausages? I'm kidding. It's terrible what you did on Twitter, by the way.

What are you doing on Twitter? I'm kidding. You had that one post about Twitter misrepresenting all of your, uh, on YouTube. Make, make belief tweets of yours.

Yeah, isn't that well? That's so fun, yeah. All's fair in love and thumbnails and titles. No, that's not right. I don't agree with that.

Well, that's my opinion, not yours. What the hell were we talking about earlier when you took me off track on the philosophical bullshit? Oh yes. Probably more philosophical.

No, no, no, I got it. So it's all the same. So, doctor's offices and telling people, hey, you should lift more weights and do this. Non-angiogenic anabolic antibiotics.

We've already started to solve the problem of food drive and appetite with medication. But now we have an even bigger problem in the muscle mass side. Used to be muscle mass, low muscle mass was something that affected predominantly older individuals, individuals of certain ethnic groups more than others. People from Southeast Asia struggle with low muscle mass.

And you've seen a lot of the metadata on their health stuff. People in their late 20s who are type 2 diabetic, and you're like, you're not even overweight. Like muscle to fat ratio is all wacky, right? And so what we can, we had, and this is going to be worse and worse of a problem over time, is the only thing keeping many, many overweight Americans, non-sarchapenic, which is to say enough muscle mass

to not cause activities of daily living or metabolic dysregulation, the only thing keeping them having high enough muscle mass was their enormous food intake, because if you eat more food, you gain muscle and fat. Now they're going to be eating less food, but they're not getting into fitness and activity, not all of them.

So you're going to see these new modern anorectic medications driving new wave of sarcopenia. Junk food and overeating has just been covering up that wave of sarcopenia. Because like a lot of overweight older adults, they're not sarcopenic, but as soon as you get them down in body weight, oh my God, they're sarcopenic. We desperately need the development

of a non-angiogenic cannibalic. Because anabolic steroid, they build muscle real well. But they come with like 18 trillion different side effects or just non-starter. if you have a non-endrogenic anabolic potentially attacking the myelastatin regulation system

which is ultra-powerful you ever see those like cows that have like two times the muscle of the regular cow or the greyhound or the mouse or whatever that is already monogenic vector of attack we could be developing

and who knows you know I'm not in the pharmaceutical back end but I guarantee some companies are working oh yeah so these are all tractable problems and as soon as we get a non-aginogenic cannabolic going we can prescribe dual therapy

So instead of coming into the office and saying You should lift weights and eat better And they're like, okay, you're like, all right, see you next Monday. You won't even be dual therapy, it would be single pill. That would be dope. The thing with, okay, so I'm not pushing back. I'm just, I'm just thinking out loud, two Jews get together and talk, like, oh, you're wrong. Single injection will be dope.

The thing is people have different genetics for muscularity and food drive. And so a single injection would kind of do a real, a ton of good. But I think two pills can also make sense because like some people don't need much more muscle, but they need much less food drive. The other way around is also the case. But in any case, let's just go with one pill, right, to make it super simple. People come in today, we're like, hey, go resistance train and eat better. They're like, dope, see, never, and they fucking don't do it.

Nowadays, now, some of them do, and that's great. But now, maybe in the future, when we get a non-endrogenic andabolic developed that's safe and effective and really very targeted, then we have the situation where people are taking a medication that not only lowers, let's say, God damn it, back to two medications, just to keep this very clear, they're taking a medication that lowers their overall body weight at a posity. They're brought the fat now. Now they're taking a medication

and does two things. One, it brings the muscularity up. And if they want to engage in resistance training for mobility, for health, for strength, for enjoyment, for connective tissue stuff, it makes that a much more fruitful enterprise. I can't tell you how many people I've consulted and trained and seen over the years

who people tell them resistance train. It's great. These are people with good genetics. They're often young. These are older people with not so great genetics for muscle. Bro, they're in the gym weeks and weeks and weeks. Something happens, but not much. If you look at the exercise science data directly,

you'll notice there are a group of people maybe like about one fifth of everyone who's in an exercise science study. They don't lift weights and all of a sudden for 16 weeks they make them lift weights for three times a week. Something like a fifth of those people gain undetectable amounts of muscle.

Like if in the first 16 weeks of a program you don't gain detectable muscle, people talk about noob gains, you know, like you gain a wildly disproportionate totality of your muscle in the first few weeks. If that ain't happening for you, man. Can you imagine your doctor says lift weights? You do.

You come back a year later. You're like three days a week. I've been doing an RPA hypertrophy app. I did it all. And they measure to do the dex. You're like, you lost a pound of muscle. That legitimately happens. So just to cut this off at the pass,

I'm not saying we need to replace resistance training in gyms with modern non-angiogenic antibiotics. They're going to be empowering for everyone. And look, if you never go to the gym, hey shit, they'll be empowering for you too. And then we can get to this world where people are in their 50, 60s, 70s, and they are lean,

and they have lots of muscle mass, It's not a ton, just a decent amount, and it's going to impact disease across the board in an unbelievably profound way. Because when I look at folks that are in their 50, 60s, et cetera, and they're soft, they're not large, they're soft. I'm thinking, fuck, man, five or 10 years, you're going to break something,

or your type two diabetes is going to go up and what do I do about this one? You know, eat better and try to make better choices. They already eat pretty well. They just don't have enough muscle to, there's no glucose sink. You solve that problem. problem. It's enormous. Now, the first wave of AI power drug discovery is already cresting.

They've been, most of the pharmaceutical companies are pretty open with what they're working on. It's not that because they're working on, look, Alzheimer's, diabetes, crazy killer problems that millions have. This, I think, is hopefully going to be next gen. And when it happens, it'll be a big deal. I think that's your most reasonable prediction that you made this far. It's more of a hope than a prediction, really. I actually... But I think it's the most reasonable. because when you look at a lot of the medications that exist in dual therapy in that way,

they're almost counteractive. So, for example, there's some medications that have an insid and then a sacrophate to coat the stomach to reduce the side effect or an opioid medication plus an anti-constipation medicine with it. So like they're always trying to pair two things that take one of the problems and solve the back end side effect.

Yes, and I think this is just insanely obvious. And usually you're very good at pushback. I haven't heard much for, you in this regard, because it's a real thing, right? It's, and I think so many people don't know that having higher muscularity within a given body is so health-promoting. And if you have a non-endrogenic in the mix,

via nutrient partitioning, most of what you eat now goes to feed the muscle because it's so hungry all the time. And so it actually is a second order effect is to keep you leaner. So for any amount of food you eat, if you're on a decent dose, of non-endrogenic anabolic,

you're actually going to be leaner because muscle simply occupies more of that space and takes more of your food. Like, you know, when you're lifting a lot and you're jacked and lean and everything, you just eat tons of food and people are like, don't you get fat?

You're like, I don't know, man. I lift weight so much and I have so much muscle. It just hungry and eats all the time. And my fat's like, damn it, feed me and there's nothing left. That is such a profound thing that I think I'm really excited

about that future development and I hope folks listening that maybe work at a pharmaceutical company can like, I don't know, talk to CEO or something, tell them, hey, there's money to be made. I'm surprised you think that right now people don't think muscle is a big component of health. I think they do, but I think they're like an order of magnitude away from how big

of a component they, like how important it is. There's a thing about recognizing the importance of something nominally and there's a thing about like, well, how important is it? Like pretty important. Like no, very important. I think people need to shift more towards this is really important. Muscle's very important. You're a Nazi. There's great takeaways from this podcast. I had fun.

I had fun too. I actually wanted to talk about like 10 other subjects and we got none of them. So that sounds like part three. Maybe we could do it on your show. I'd love that. Yeah. If you, you know,

I'm still waiting for the invitation. You're too important to invite. We've invited you 10 times and your, your butlers keep saying that the males going to some other part of the compound they call it. Okay. Let's make it, what do they call it?

It's a smart goal. so at least let's be specific when I come on your show what topics are we talking about jeez you're making me brainstorm live live people are going to see how that mind works sure no problem flex the jew brain got it i would love to talk to you about if i am a male in my 30s and 40s and 50s i lift regularly. I eat well, but I don't know anything about doctors and medicine and pills and what I could be missing and all this other stuff. Maybe I'm on TRT, maybe I'm not. When I go to talk to my doctor, what labs do I need to be curious about? What is A1C? What does that

mean? How do I know that what I'm doing today is setting me up for health and longevity and muscularity later versus like, dude, you're on the real wrong path. I know you lift and eat well, but like you miss this whole thing that real doctors know about. Because I teach him about exercise stuff and general health stuff, but I know almost nothing about the medical side. I would love for you to fill in the blanks of like, how do you talk to your doctor about blood work, what other measures can you take, what really are the most profound things?

Are there any medications you need to be taking? Another one is this. What multivitamins and multiminerals should I be taking? Can I ask my doctor to test me for deficiencies? Because a big thing is the great canon has been so far. If you're eating a well-balanced diet, you don't need a multivitamin. And that's true, but still millions of Americans have various vitamins and mineral deficiencies, low-grade ones.

But if you fix them, you're going to get some ROI. Is that a thing I talk to my doctor about? Because unfortunately, you can talk to doctors about it. But you can go, no offense, to the local health food store. And they're like, yeah. Yeah, you can fix everything. We got all kinds of stuff to sell. The whole premise of that, like just to touch on it so briefly to end this podcast, is validation of when you change something, whether or not it creates a clinical impact and whether or not it's valuable to spend the time, as we said, and how important it is with limited time to make a change, is the same way that I think about protocols from Gary Brecker, from Huberman, from Peter Atea, and there's nothing. You went down the scale of like empirical believability.

Yes, but the problem is all three of them function in the same world where they create individual protocols that they set themselves as experts in their own right. And I say experts like this because it's clearly a wide variability. One has a bachelor's degree, one is a PhD, one is an MD, so there's variability and expertise, and yet they have their own protocols expertly derived. And here's why I don't buy into that when they disagree with an organization. like the CDC, American Heart Association, AAPFP, the American Academy Family Physicians,

because the recommendations that those groups give me as a clinician is validated. So what's the current world record for Bench Press? Well, I broke it yesterday in my own home. So what was? I think it's just shy of- What is the recorded? I think it's just shy of 800 pounds.

Okay. If I was to tell you, non-jokingly, that I bench 950, what would you say to me? being that you are you and look like you look? Yeah, yeah, yeah, everything. I mean, power lifters will find this funny. I'll be like, oh, what federation and with what triple ply shirt?

But that's an austere reference. So I would say, oh, that's cool. And then I would tell my friends you're insane. Right. And why do you jump to the conclusion that I'm insane? Can you prove that I'm insane? With the way I understand proofs to work in philosophy, probabilistically through inference, yes.

Probabilistically. Yeah, oh, yeah. But not with 100% certain. No. Well, you could just be a total freak. Totally. So I can't disbelieve their protocols. Just like you can't 100% disbelieve that I'm saying.

But there's enough reasonable certainty and probability that they don't have the validated. Bench press shirt, Federation judge. Whatever. Watching you form. Yes. Whatever it is, that minutiae that's incredibly important to judge whether or not that thing is true and validated, that I can't buy in. into that and recommend it on a general scale because it might be true, but they need to go

and validate it for me before I start telling it to people. And that's my issue with the protocols. Totally. And what my audience would like to hear, I think, are not protocols. They get those plenty from those other folks. I think what they would like to hear is how to think about the situation of I'm an adult who's pretty healthy, who exercises and eats well. But what about on the medical and diagnostic side do I need to be aware of and talk to my doctor? And to talk to my about. Yeah, I think a good thing for us to talk about would be how doctors are trained to go into a visit when they think about prevention, treatment, catching things early, what we're trained to do versus what I'd like for some doctors to do more of. Yes. And what to do if your doctor's

not. Huge. That's a that really is it because the subset, a lot of times doctors will do that thing I talked to you about earlier where like 55 year old is made of mush. They're like, your blood work looks good. See you next time. For fitness people, it's extra more of that conundrum because they're like their blood work is great. I mean, it's just stellar for their age, but they want more. They want an extra insurance policy of health and fitness. And because the doctor deals only in generalities, because that's how they were trained and that's most of the population, they never get the care and attention they need. And another thing I'd love to ask you about in the future is like, how do we go about selecting a doctor that works more with fitness

people and knows, okay, you want extra A plus attention because you're willing to do it, then what do you look for because here's a big problem most of the people that are looking for the a plus in fitness go end up being like my doctor is a 70 year old man who thinks that because I lift weights I'm going to hurt my back and even though he's okay with my blood work and everything he says you're fine you're fine you're lots of doctors you're fine everything's fine see you later 15 minutes are up who's left over to go to if we can't find an evidence based practitioner that can give them that extra boost like look let's look at your vitamin D levels over every three month time span things that aren't worth most the general population, but are worth it to you.

Let's do it in an evidence-based way that makes sense. But there are so few of those people around and so difficult to find, I'd love to ask you about how to find them, how to get to know, because usually these people end up going to fucking quacks. And they're like, well, this guy's the only one talking about enhancement. You know, like the human, whatever fuck, Gary Breka says. I'm a human biologist. Like, oh, I usually speak to primatologists about this, but I'm just being a dick.

Well, to talk about Dr. Gundry, going to give him a nod, he kept telling me about Our great apes only eat fruit during parts of the year. Therefore, we should not be. I don't know, but he kept telling me that. And I'm like, I don't really know what to make of that. It sounds profound. Because he said we shouldn't be eating fruit all year round. And I'm like, well, everyone knows that.

I'm like, well, clearly humans that consume fruit are really the problem in our country. That's who the least healthy people are. It's a linear correlation. The people who eat fruits and vegetables, disgusting animals. Yes. I actually can, I do know a little bit of something about this. the sort of like annual variations in food consumption.

You see, Mike, when the sun hits the fruit, I got nothing. That's honestly refreshing because saying I don't know is sometimes more powerful than creating a story about create apes. It's a story of my life. Thank you. Mike, I appreciate you. I love it. Thank you so much.

Always a pleasure having Dr. Mike Isretel on the podcast. You could tell that even when we disagree, we're really truth seeking together. and that makes for a really insightful conversation. If you enjoyed it, please don't hesitate to give us five stars, potentially leave a comment, as it's the best way for this show to find new viewers. If you're looking for another great conversation, check out mine with Dr. Jonathan Haidt,

who has some really hot takes about social media and its harms. I kind of push back on it well worth a listen. And as always, stay happy and healthy. Thank you.