The Diary Of A CEO with Steven Bartlett - The Groundbreaking Cancer Expert: (New Research) This Common Food Is Making Cancer Worse! Cancer Is Getting Worse Worldwide & It Might Not Be Genetic, It's Your Diet!

Episode Date: October 7, 2024

Could fighting off the most feared and deadly disease be as simple as controlling what you put on your plate? Here is the revolutionary cancer care advice you’ve never heard.  Dr Thomas Seyfried is a Professor of biology, genetics, and biochemistry at Boston College. He has over 150 peer-reviewed publications and is also the author of books such as, ‘Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer’.  In this conversation, Dr Thomas and Steven discuss topics such as, the link between blood sugar and cancer growth, how stress management impacts your cells, the biggest misconceptions about cancer, and how calorie restriction could prevent cancer. (00:00) Intro (01:59) What Would Dr Seyfried Say He Does? (02:37) How Much Of A Problem Is Cancer Globally? (04:30) What Types Of Cancer Are People Dying From? (05:02) How Many People Will Develop Cancer? (06:56) Where Does Cancer Rank In The Probabilities Of Taking My Life? (08:12) What Is The Fermentation Process? (12:16) How Have You Arrived At This Conclusion? (16:52) Why Do Cancers Grow So Rapidly? (19:17) What Are Ketones? (21:23) What Can We Learn About Cancer From Our Ancestors? (24:36) What Role Does Exercise Play In Fighting These Diseases? (25:44) What Lifestyle Choices Are Causing The Cancer To Develop? (29:07) Is Cancer Genetic? (31:09) How Do We Keep Our Mitochondria Healthy? (32:42) Is Cancer Genetic? (36:27) Why Haven't Opinions Changed Based On Dr Seyfried's Evidence? (38:27) If We Adopt This Mindset, What Will Happen To Cancer Statistics? (39:17) Are The Current Cures Working? (41:50) The Current Technologies Used To Prevent Cancer (49:10) How Do We Prevent Cancer? (51:06) Should I Be On A Keto Diet? (54:57) Dr Seyfried's Dog Study (57:14) Human Cases Of People That Have Followed Your Research (01:03:39) What Is Metabolic Therapy? (01:04:36) What Should Someone That Has Cancer And Is Listening To This Do? (01:07:52) Keto Plus Hyperbaric Oxygen Study (01:11:57) Can You Have A Pre-Disposition To Cancer? (01:12:28) Should I Restrict What I Eat, To Stave Off Cancer? (01:13:16) What's Your View On Fasting? (01:13:58) How Do I Get Into The Keto State? (01:17:10) Do We Need More Discipline? (01:18:36) What Happens When You Fast? (01:20:52) What Advice Would Dr Seyfried Give To His Kids? (01:22:14) Why Isn't Dr Seyfried Trying To Be Metabolically Perfect? (01:23:04) What Food Laws Would Dr Seyfried Introduce? (01:25:18) Is Dr Seyfried Hopeful? (01:28:14) And What If You Are Successful? (01:29:10) Are There Any Studies That Have Broken Dr Seyfried's Heart? (01:30:50) What Would Dr Seyfried Say To Someone Listening? (01:32:55) Guest's Last Question Follow Dr Thomas:  Instagram - https://g2ul0.app.link/cwAePGF1pNb  Twitter - https://g2ul0.app.link/0yuLM6I1pNb  YouTube: You can purchase Dr Thomas’ book, ‘Keto for Cancer: Ketogenic Metabolic Therapy as a Targeted Nutritional Strategy’, here: https://g2ul0.app.link/1FotHad2pNb  Spotify: You can purchase Dr Thomas’ book, ‘Keto for Cancer: Ketogenic Metabolic Therapy as a Targeted Nutritional Strategy’, here: https://g2ul0.app.link/1FotHad2pNb  Watch the episodes on Youtube - https://g2ul0.app.link/DOACEpisodes  My new book! 'The 33 Laws Of Business & Life' is out now - https://g2ul0.app.link/DOACBook  You can purchase the The Diary Of A CEO Conversation Cards: Second Edition, here: https://g2ul0.app.link/f31dsUttKKb  Follow me: https://g2ul0.app.link/gnGqL4IsKKb  Sponsors: Shopify - http://shopify.com/bartlett

Cancer is very preventable. When the medical establishment acknowledges what I know about this disorder, what's causing it, and what we're not doing to prevent it or treat it, it will be recognized as the greatest tragedy in the history of medicine. Thomas Seyfried is a professor of biology, genetics, and biochemistry who has dedicated the past 30 years gathering scientific evidence on what could be the true origin and prevention of cancer. Cancer is getting worse, and there's no major advance in reducing death rates, and I can

speak to the reasons for that. All major cancer research centers think cancer is a genetic disease. You believe otherwise. It's not whether you believe, it's what the data tell us. And the evidence is massive to support that cancer is a metabolic disorder. And the problem is we're doing everything we possibly can in our lifestyle

to induce it. The scientific evidence is there. Like, for example, we know that cancer was extremely rare in African tribes that were living according to the traditional ways. But when modern lifestyle entered into their societies, cancer out of control. We even did a study on dogs. We know that wolves in the wild don't die from cancer. But cancer is the number one killer of domestic dogs. Why? It's because of our lifestyle

issues. And a lot of us are doing things without the knowledge that it would put us at risk. But with metabolic therapy, you can use it as both a prevention and a treatment. And we're seeing more and more of hormonal cancer patients outliving their predictability because of this. And let me tell you one thing and remember it. If you do metabolic therapy, you can actually reduce risk for cancer. You can take away the fear. And when you say metabolic therapy, you can actually reduce risk for cancer. You can take away the fear. And when you say metabolic therapy, tell me what those things are. Number one. Professor Seyfried, if someone walks up to you on the street and they're, you know,

they know nothing about science, they know nothing about medicine, etc. And they asked you, what do you do and why do you do it? How would you respond? I'm a professor of biology at Boston College. So in that role, I spend a lot of my time working with undergraduates and graduate students in training them to be scientific literate in various aspects of biology. The research program that we have at the university is also focused on understanding how to manage cancer better, how it originates, and how to prevent it. How much of a problem is cancer globally? What are the sort of headline statistics on the macro view of cancer for someone that really doesn't know? Yeah, well, it's getting worse.

I can't say— it's in the millions. I know precisely what's going on in this country because the American Cancer Society every year distributes the data on cancer. We have almost 2 million new cases diagnosed per year in the United States. And we have 1,700 people a day dying from cancer in the United States, which comes to about 70 people per hour in the United States.

Now, when I went to China, I looked at some numbers there, and it was 8,000 people a day are dying from cancer. Obviously, the population is so much larger. And I don't know what it is in the UK. I mean, we'd have to go to their cancer registries. But what we do know is that it's supposed to be a lot worse by 2050 than it is today. So there seems to be no reduction in death suffering for this disease. And I can speak to the reasons for that. But right now, I would say

it's a global epidemic of cancer. It's not getting better. It's getting worse. More people are dying from it. There's no major advance in reducing death rates. So it's a great tragedy. And when we understand what's causing it and what we're not doing to prevent it or treat it, it'll be recognized as the singular greatest tragedy in the history of medicine worldwide. When they come to know what I know about this disorder, and then they realize what we've been doing in a misdirected way, it will be recognized as the greatest tragedy in the history of medicine. What types of cancer are people dying from? misdirected way, it will be recognized as the greatest tragedy in the history of medicine.

What types of cancer are people dying from? What is the most popular types of cancer for men and women? Well, it's always been lung cancer, pretty much for men and women. Lung cancer has always been the number one. But we have pancreatic breast cancer, colon cancer. These are all on the rise. Colon cancer is on the rise. Pancreatic cancer is on the rise in this country. I can't speak for other countries. They may vary slightly due to diet and lifestyle issues. But lung cancer has always been recognized as the number one cancer. How many people in the United States then, based on the statistics, would develop cancer? Well, it seems to increase every year, so it's kind of a moving target. It doesn't seem to go down. You know, what it is today, I don't know. But what I do know is the numbers of people that are dying each day. Because the American Cancer Society comes out with, I think it's 612,000 people will die this year, 2024, from cancer in this year.

So divide it by 365, and it comes out to just about 1,700 people a day. Divide that number by 24, and you get about 70 people an hour, based on the numbers provided to us from the American Cancer Society. When they say we've made major advances in cancer incidences, right? So in the 1990s, they instituted the anti-smoking campaigns, all right? So today, if you read, they say we have reduced cancer deaths by 31 or 32 percent. Wow, that sounds really impressive. So what they do is they take the number.

This is what the National American Cancer Society has done. It's published in their papers. Okay, if we didn't stop smoking in the 90s and everybody continued to smoke, the trajectory would be very, very high. Because we stopped smoking, we have 33% lower death than if we didn't stop smoking. But the trajectory is continuing to increase,

maybe not as steep as it would have been had we continued to smoke. So it was clearly a prevention. It had nothing to do with a treatment. It had to do with prevention that was giving the, oh, we've made major advances in reducing cancer death rates. Yeah, because people stopped smoking. For many, many people, more people would have died had they not smoked. So we have people that are not real people.

We're just looking at what would have happened if we didn't stop smoking. What are the leading causes of death worldwide in terms of diseases? I hear that heart disease is number one. I think that heart disease is number one. I think that heart disease is number one. Cancer is number two. Okay. And there are many different types of cancer, right? There's hundreds of different forms of cancer. If you look under the electron microscope, or a correction, even a light microscope, this is how most cancers are diagnosed by light microscopy. You look under the microscope and you see a bunch

of cells that are dysmorphic in the way they look, and then they all have genetic defects and all this kind of stuff. But they all have one thing in common. They depend on a fermentation, energy without oxygen. So all cancers are a singular type of disease. It's just that they happen in different tissues. But when you look at the underlying problem, they're all very, very similar. They can't live without a fermentation, which means energy without oxygen. So that's the common pathophysiological problem in all cancers, whether it's a colon, brain, breast, bladder, skin, lung. We've looked at all these cancers, and they're all essentially using the same mechanism to grow out of control. So what is that fermentation you mentioned?

Fermentation is energy without oxygen. What does that mean? We breathe air, and we exhale CO2 and water vapor. And those are the waste products of the food that we eat. Everything is broken down and combusted in our mitochondria of the cell. And the waste products are CO2 and water vapors. Those are the waste products. But if you and I were to stop breathing for any particular time period,

our bodies would fill up with lactic acid and succinic acid, like if we were to have a heart attack or when somebody has a heart attack. They don't die instantly. If they're there for five or seven minutes without oxygen, they may die because the brain dies. But if you can get the heart to beat again and get oxygen back in the system, you can come alive again. But when we have that massive interruption of oxygen into our body, the cells fall back on an ancient, they immediately turn on these ancient pathways to get energy without oxygen for a short period of time. And that's the sugar glucose, which is already in our bloodstream from the food we eat, and the amino acid glutamine, which is an

amino acid in our bloodstreams. Highest level of amino acid is the glutamine. These two fuels are now burned for energy, obtain energy without oxygen. These pathways upregulate, and you can get ATP, which is energy, to keep you alive for a short period of time. But your bloodstream is filling up with the waste products called lactic acid and succinic acid. Lactic acid is coming from glucose to sugar, and succinic acid is coming from the amino acid glutamine. And they build up, and that tells you you're fermenting.

You're getting energy without oxygen because you're not breathing. Very simple. You're not breathing, but I'm not dead yet. Now, of course, if you don't get it for very long, you die. It's just that. Now, the other way you can stop oxygenation in our bodies quickly is with the poison cyanide. So if we, God forbid, we were to take cyanide, we'd be both dead within a minute. We'd just, because our bodies are completely shut down

of energy from oxygen. Now, here's the cancer cell. The cancer cell can live in cyanide. Cyanide does not kill a tumor, okay? Otto Warburg showed this a long time ago, and we've also shown the same thing in our lab. Others have shown this. The interesting thing is when you look at cancer cells, even in the presence of oxygen, even in oxygen, they're throwing out lactic acid and succinic acid. What does that mean? That means the organelle inside the cell that generates energy is not efficient. It's inefficient. And the cells are using ancient fermentation. And when I say ancient fermentation, you have to realize the Earth is four and.5 billion years old. The organisms that existed on our planet 2.5 billion years ago were all fermenters. There was no oxygen in the atmosphere until the photosynthetic bacteria started making

oxygen. There were living cells. They had no oxygen. And they were growing like crazy, unregulated growth. Just unregulated. What's going on here? And they would die as soon as the fermentable fuels were dissipated. As they gobbled up everything, they unregulated. What's going on here? And they would die as soon as the fermentable fuels were dissipated. As they gobbled up everything, they would just die. So they lived

as long as they could reproduce and have fermentation fuels. The cancer cell in our body is doing nothing than falling back on these ancient fermentation pathways that become accelerated, upregulated in the tumor cell because the efficiency of the energy coming from the mitochondria is now depleted. It's defective in many different ways. So this is very clear. And this happens in lung cancer, colon cancer. We've looked at all the major cancers. And we found out these common defects are seen in all the cancers. So they're all very similar in their metabolism. They're very different in what they look like under the microscope. Lung doesn't look like colon, doesn't look like brain. They're very different genetically. They're all different from each other, but they're all common

in a dependency on this ancient pathway of energy metabolism. Can you take me back? You mentioned a guy called Walt Wahlberg there. Yeah. Can you take me back on the journey that the scientific community, or at least you have been on, to arrive at the conclusion that the central sort of causal factor, or at least an indication of the causal factor of cancer, lies in this shift in energy systems? Where did this understanding start in research? Well, it started with Otto Warburg, for sure, in the 1920s. The other linkage, before I tell you what Otto Warburg did, because I was like everybody else.

I thought cancer was a genetic disease. And I heard about Warburg, didn't really know what he was talking about or invested any time thinking about what he said. But Linda Nebling was a PhD nursing student at Case Western Reserve University in Ohio. And she took these two little hopeless kids, brain cancer, we call hopeless cases when they have no predictability of long-term survival. And she gave them a ketogenic diet, the lower blood sugar, and she was able to rescue these kids. One eventually died, the other one was lost to follow-up. And she said her strategy was based

on what Otto Warburg had said about glucose and cancer. So then I said, Warburg? I said, who the hell? Let me go back and check out who this guy was and what he did. Because I was seeing similar things in the mouse with that drug. It was lower in glucose. And we were shrinking these tumor cells. And we published a paper, one of the first ever papers linking that how high your blood sugar is determines how fast your tumor will grow in the mice. And now this has been replicated in all human cancers. The higher your blood sugar, the faster the tumor grows. The lower the blood sugar, the slower the tumor grows. Undeniable for all different human mouse cancers. Wow. So Warburg had said this a long time ago, back in the 1920s.

He was taking slices of all kinds of human and rat mouse tumors and slicing them up. And he noticed something really strange about these cancers. They take in less oxygen compared to the normal tissue from which they came. Wow. So they're kind of like oxygen deprived. And they were throwing out this lactic acid waste product that he was saying. And they were taking in so much more glucose than the normal. So the normal cells take in just a little bit of glucose, and they can make tremendous

energy from a tiny amount. This guy was taking in huge amounts of glucose, but not fully metabolizing it to CO2 and water, but dumping it out as lactic acid, which is a breakdown product of glucose that is not fully metabolized in the cell. Wow, he said, this is unbelievable. And then he did all kinds of tissue. I looked at his data. It was unbelievable.

He was cutting humans, mice, rats, and seeing the same thing over and over again. And he was saying the origin of cancer has to do with something in the ability of the mitochondrion, the organelle, to generate efficient energy from oxygen. So the mitochondria is the part of the cell that creates energy? It's the part of the cell that creates energy through oxidative phosphorylation, which is burning energy using oxygen. Okay. Okay, so it's like an engine.

It's an engine, a very highly efficient engine. This is an organelle. You have to realize we have the cell. Yeah. And we have a nucleus that everybody knows about, this nucleus. And then we have all these little organelles in there. We have lysosomes, and we have the mitochondrion, which is like a spaghetti network inside the cell. They fuse.

It's actually a second living organism inside our cells. And to simplify what they do, the mitochondria, they convert oxygen and glucose into energy? Yes, and they combust energy. They take the foods that we eat, have carbon-hydrogen bonds, okay? And we break those down inside our mitochondria. And when we break those bonds down, we create a hydrogen gradient, and we dissipate that gradient through an impeller mechanism

that generates energy like crazy. It's unbelievable. Very efficient, highly efficient. But the cancer cell has corruption in that system. But it doesn't happen overnight. As Warburg said, if you break that system too acutely and too fast, the cell will die. It doesn't have the... So you have to have two things to get from oxidative phosphorylation to energy with minimal

oxygen fermentation. Sorry, just to keep it simple, from a normal cell to a cancerous cell. From a normal cell to a cancer cell doesn't happen overnight. It's a chronic damage to the ability of that organelle inside the cell to generate efficient energy. So all we have to know with cancer is that how are they growing so rapidly? Why are they going out of control? How come it's so hard to kill them. Because as long as you have those fermentable fuels that drive this ancient fermentation pathway, they will continue to grow. They're very hard to kill. And the fermenting fuels are glucose and? And glutamine. Glutamine.

Yeah. Okay. So here, let me tell you in a nutshell. Are you ready? Brace yourself. Are you ready? I'm ready. Are you braced?

Are you braced? Sufficiently braced. He's sufficiently braced. Okay. So a solution to the cancer problem to manage cancer without toxicity is to simultaneously restrict the two fuels that are needed to drive this dysregulated growth while transitioning the whole body off to a fuel that the tumor cells can't use, which is fatty acids and ketone bodies. So when we take the cancer patients or the mice, we put them into a calorie restriction, lowering the blood sugar that I said is one half of the two fuels. You can lower that down really, really low. And then we use specific drugs to target

the glutamine. And together, we can selectively restrict the two fuels while we transition the whole body over to ketones. We, as a species, evolved to be in nutritional ketosis for the majority of our existence as a species, like one and a half million years. For centuries and centuries, thousands and thousands of years, our species, you and me, our ancestors, were always in a state of nutritional ketosis because there was very few carbohydrates in the environment for them to be consuming, right? So the cancer cell, the body, you and I could, if we stopped eating and we took a low-carbohydrate diet and just did water-only fasting, we would get into nutritional ketosis, where the normal cells, our brain, our kidneys, our heart, can be burning these ketone bodies because they have a good mitochondria,

and they can burn these fuels effectively. The tumor cells have a bad mitochondria. They can't burn those fuels. They're dependent on glucose and glutamine. We can replace glucose and glutamine with ketone bodies in the normal cells of our... So we selectively marginalize these tumor cells slowly over time. They slowly start to die. The blood vessels disappear. And the body comes in and dissolves them. So for someone that has never heard the term keto before, ketosis or ketones, in a simple way, what are ketones?

Ketones are water-soluble breakdown products of fatty acids, okay? They're beta-hydroxybutyrate, acetoacetate. These are small molecules that are water-soluble. The liver throws them out like crazy. Kidney a little bit, but mostly liver. So as I told you earlier, when we don't eat, you get anxious, mainly because our brains are addicted to glucose. It's like cocaine and nicotine and whatever. You start getting all antsy, like I haven't eaten anything, you know. What's going on? So then once the body realizes you ain't going to eat anything, we have to start mobilizing out of our fat resources. And the fats go into the bloodstream as triglycerides,

which are three fatty acids attached to a glycerol backbone. They go to the liver. The liver chops them up and puts out these little water-soluble ketone bodies. The name ketone body is kind of a weird thing from biochemistry, but they're called ketone bodies. And they can supply the brain with energy, the heart with energy. And not only that, they're a super fuel. It's unbelievable that mitochondria burns these ketones. Okay. But remember I was talking about how energy efficient the mitochondria become? When they burn ketones, they become even more energy efficient. It's unbelievable how they don't need as much oxygen to generate more energy. That's why my colleagues called,

and some of the greats in the biochemistry field called them super fuel, because you can get more energy bang for buck burning a ketone body than you can burning a pyruvate coming from glucose, or even a fatty acid. And the biochemistry for that is interesting. But the bottom line is when you transition away from these fuels to ketones, don't forget, we evolved. Our ancestors were always in a state of ketosis. You get into that state by consuming very few carbohydrates and having a lot of energy.

And this is the way our ancestors were. So what can we learn from our ancestors about cancer? How prevalent was cancer when we look back at our ancestors, if they were often in a state of ketosis? Yeah, well, it's hard to determine from skeletal records. But I think we can look at modern man who live according to their traditional ways. You know, Albert Schweitzer, the great humanitarian physician, went to Africa and looked at Africans that were living according to their traditional ways. He said, one of the weirdest things, they don't have cancer. It's like, what?

The cancer was extremely rare in Africans in a wits living in the areas, British when they came in looking at the health conditions of folks that lived in the Arctic Circle. Cancer was not there. They had other things, but they didn't have cancer. Aboriginal folks. So it seems as though our living, we can't go back 50,000 years ago because we don't have people to examine. But we have people to examine today. And that was one of the things Schweitzer and several other physicians from Europe would go to Africa.

And they would look at some of these tribes that were traditional. And they would say, whoa, what's going on with these Africans? How come they don't have cancer? But when modern diet and lifestyle entered into their societies, cancer out of control. What about our other primate cousins? Yeah. There's never been a documented case of breast cancer in a female chimpanzee, and they're 98% similar to us in gene and protein sequence. You know, what's going on with that? Monkeys, they don't generally form cancer. They're eating.

They're not eating what we eat, okay? Don't forget, we did not evolve to eat pork pies and Dunkin' Donuts, jelly-filled donuts and pizzas. We did not. Our ancestors did not eat this, right? We were killing and eating animals. As I said, we ate everything that walked, crawled, flew, or swam on this planet became part of our diet. We did not have donuts on every corner, delicatessens on every corner. We evolved over this period of time, just like our primate ancestors.

The animals, chimps and gorillas and things that you see in the zoos, are fed their natural diets as if they were living in their habitat, their natural habitat, whether it was in South America, Africa, or wherever it was. We're not throwing in jelly donuts every day and pizza pie into the chimpanzee pen. And as a matter of fact, I even went to the zoo down here in Boston, Franklin Park Zoo, and also at the San Diego Zoo. I said, how come you guys don't give these guys, run down and get a big pizza for these animals? Oh, no, it would be animal cruelty. Their systems aren't geared for this. Well, neither are we. We have an obesity epidemic.

We have all these different chronic diseases. Why? We didn't evolve to eat all this crap that we're eating today. So what I've told many people in these podcasts is that our food science and technology and our society's technology has evolved so much faster than our biology. Can you explain to me, in simple terms, the role that exercise is playing in staving off cancer? Well, exercise lowers blood sugar, you know, and also lowers glutamine. So the two fuels that are driving, now we can't completely remove glutamine by exercise, that's for sure. But my late good friend George Cahill published some papers on showing how

exercise could actually lower glutamine availability. So it's a little bit of a push. But you're also, when you exercise, you're burning and you're not eating a lot of carbs, your mitochondria are burning ketones, and the oxygenation from all the exercise is keeping those mitochondria super healthy at their highest level of energy efficiency. So exercise- You're building muscle as well, aren't you? Yeah, you're building, well, you can build muscle, but you're certainly getting aerobic exercise. Oxygen is coming in, and you're burning ketones, which I already told you is a super fuel. So your body is super healthy.

These bodies from the Paleolithic period, these men were jacked. There was no obesity in these people. They had tremendous energy. They're not dying from the things that are killing us. They're dying from injuries and infections. When you described this slow and gradual shift in the cell as it moves to this sort of ancient system, it sounded very gradual. So in my head I thought, okay,

so does that mean that the cancer is a gradual process that is kind of building up in me or isn't building up in me based on the lifestyle decisions I'm making and my environmental factors right now? I'm trying to say, does cancer start slowly, years before you find it? Yeah, it is a gradual process,

but it can be impacted by several provocative agents from the microenvironment. Lack of exercise, okay? So we're not exercising nearly as much as our Paleolithic ancestors, bar none, right? We have massive amounts of processed carbs in our diets. We have a lot of emotional stress, mental emotional stress that's impacting negatively on our biology. We have lack of sleep. Sleep, a lot of us, because we have stresses. You have to have, when you put all of these impactful things together in one person, you can put yourself at risk for cancer,

all of which will damage and reduce the efficiency of mitochondria. And also the joy of living, having friends and friendships and this kind of thing reduces stress in a lot of different ways, makes people enjoy getting up and having a nice day rather than being depressed or these kinds of things. You put all this together and you put yourself in a diet and a lifestyle that puts you at risk for damage to oxidative phosphorylation and the transition from one form of energy to a fermentation energy. And what I'm trying to understand, is that a gradual process?

It's a gradual transition. You have to be able to do that. And how long does it take for a colon, a group of cells in a crypt of your colon, to transition from one stage to another. You have to be constantly under stress, those cells and that organ. Now, why somebody gets colon cancer, another person gets breast cancer, another person gets bladder cancer, and some person gets a brain cancer and all these different kinds of cancers.

Whatever happened, the process was causing a gradual disruption of oxidative phosphorylation, oxidative respiration, and a gradual transition to a fermentation. Like in the brain, the neurons rarely, if ever, get cancer. But the glial cells that support neurons, they are usually the source of the origin of cancer in the brain for those kinds of cells. And you can look at different cells, and some are more or less prone. And why this guy got lung cancer from smoking cigarettes, this guy got bladder cancer from smoking cigarettes. How did it all start? It all started from a population of cells in one of those organs having a chronic, not instant, a chronic interruption of oxidative energy followed

by an upregulation of this fermentation energy. So really, we need to be thinking about all the things that have caused dysfunction in the mitochondria. Absolutely. I want to get a list of the key things that are associated with causing this dysfunction. OK, carcinogens. OK, so carcinogens. Yeah, and you know, there's many, asbestos, there's all kinds of chemicals in the environment. You hear about this, oh, there's a whole list of carcinogens.

And they put them on the labels on different chemicals. They say carcinogenic potential and whatever you have. What are the types of things that are carcinogenic that most people don't realize? Oh, well, now we're talking about microplastics. We're talking about... Is that in part what causes breast cancer? Because I always think about deodorant with breast cancer and the stuff that we're kind of lathering onto our arms.

Yeah, well, the one that was most interesting was the talcum powder one. How does talcum powder would cause ovarian cancer? Okay, it's taken up into the urogenital tract, and it forms a foci in a part of the ovarian tissue. What's a foci? A locus, like a collection of material. A foci is an area where, say, talcum materials would be accumulating. And that leads to an inflammatory area of the body. And our immune system comes in to see what's going on.

Our immune system is a healing machine. And they see something that's not normal. Normally, they would clean it up. But they see something that's not normal. Normally, they would clean it up. But they throw cytokines and growth factors on there, leading to damage to mitochondria and dysregulators. And then you get this tumor that starts. So if I get a talcum powder granule or whatever, and it goes into my body, my body then tries to attack it to sort it out. And in doing so, it creates inflammation, which leads to... Damage to mitochondria in a particular group of cells near that foci.

Okay. And this is applicable to, I guess, a lot of different nanoparticles. Yeah. And microplastics are this now. They're looking at this. But then we have chemical carcinogens, tetrahydrochloride. There's all kinds of other things that can actually damage arsenics and these kinds of chemicals, urethane, anything that could chronically damage a mitochondrion, forcing, over time, forcing it to upregulate the fermentation energy without oxygen. Isn't this most things? I'm trying to figure out how to live my life. Yeah, well, that's why it was called the oncogenic paradox. But you can avoid

that. That's why I'm saying, if you can keep your mitochondria healthy, exercise and reduce consumption of highly processed carbohydrates. Do I need to be avoiding these microplastics as well? You know, the problem with microplastics, they're very ubiquitous. We're not really sure. We're just now becoming aware of it. Nobody really knew that before. Look it up. But it could cause small foci in different populations of cells. But you know, it's very hard to really chronically damage mitochondria. Mitochondria are tough organelle. The problem is we chronically abuse it without realizing what we need to do to keep it healthy. So even if you are exposed to chemical carcinogens, even if you are exposed to all these things,

but you're keeping your body as healthy as you possibly can, you could possibly delay or even prevent the damage to the mitochondria, even though you are being exposed to this. So it's actually in your hands. You can actually reduce risk for cancer by knowing what keeps your mitochondria healthy. Vigorous exercise, fasting, water-only fasting. You know, it's very hard. But sometimes when we were putting mice on calorie restriction, it was hard to get them to get tumors. Their body was so healthy.

This was shown years ago by a couple of scientists and mice, using mice that developed a lot of breast cancer. If you put them on a calorie restricted diet, the incidence was way, way down. So cancer is very preventable. It's a very preventable disorder. It's just that we're doing everything we possibly can to induce it in our diet lifestyle. A lot of big institutions believe that cancer is a genetic problem. You believe otherwise? The evidence is striking. I mean, it's not whether you believe, it's what the data tell us. Okay, so according to the somatic mutation theory of cancer, mutations in the nucleus

lead to dysregulated cell growth. That's the somatic mutation theory of cancer. Mutations in the nucleus lead to dysregulated cell growth. That's the somatic mutation theory. In the mitochondrial metabolic theory, it's a transition from oxidative phosphorylation to a fermentation metabolism inside the cell. The mutations are largely irrelevant. What do you mean by that? When the mitochondria become defective,

they throw out ROS, reactive oxygen species, that are carcinogenic and mutagenic. Whoa, what does that mean? Causing mutations. So a lot of the mutations that we see in the nucleus of the tumor cell that is the subject of the somatic mutation theory are downstream effects of the dysfunction of the mitochondria. So the mitochondria is causing a downstream effect, which are mutations, which, according to the somatic mutation theory,

are the cause of the dysregulated cell growth. Let me tell you why that's absolutely untrue. There's some cancer cells growing out of control that have no mutations and normally not discussed. Well, how can that be? That's a challenge to the theory. If the theory says that all cancers have mutations and you have some cancers that have no mutations, and they're growing out of control, that should

say, oh, bell rang one. Then the somatic mutation people, people who think this, said, oh, okay, we have a problem here. Not all mutations are the ones that cause the dysregulation, only some. And we have a name for those some. That's called driver mutation. Okay, now it's a nice term. Because some of those mutations are called passengers. They don't really do anything. But the drivers are the ones that lead to the dysregulated cell growth. So we should be focusing our attention on these driver mutations.

New evidence from the recent scientific literature. Can you believe this? They're taking tissue, normal tissues from patients, different organs and things like this, from not patients, from normal people, no cancer, perfectly like yourself here. We would take tissue from you and say, oh my Christ, look at that. You've got driver mutations in your esophagus and your different parts of your body. You've got driver.

But you don't have a tumor. What's going on with that? How do you explain that these driver mutations are causing dysregulated cell growth when we have thousands of driver mutations that are there that are not causing dysregulated cell growth. Oh, okay, that's another problem. The biggest devastating information against the somatic mutation theory is if you take the nucleus from a tumor cell, cleanly take it out of the tumor cell, and you have another normal cell here, you take the nucleus out of the normal cell, and you put the tumor cell into that cytoplasm, you get regulated growth, no dysregulated growth.

But if I have the normal cell and have a tumor cell, take the tumor nucleus out of there and take the normal nucleus and put it into the tumor cytoplasm, which contains defective mitochondria, dysregulated cell growth. This has been seen over and over and over again. So just to summarize that, so if you take the tumor nucleus out of the cell and put it into a normal healthy cell, everything's fine. Everything is fine. But if you take healthy cell nucleus and put it into a tumor cell, you still have the same- Dysregulated cell growth. Tumor growth, which means that it's not the nucleus.

Absolutely. It's something else. It's something else. And that's the mitochondria. And I told you, then you have cancer cells with no mutations. And then you have driver mutations in normal cells that never become cancer. You put all those things together. And you have to be a hopeless ideologue to think that cancer is a genetic disease. It's a silent assumption in the field that cancer is a genetic... Every textbook of biology, cell biology, and bio... Cancer is a genetic disease. Why hasn't people's opinions changed despite the evidence that you present?

It's a very difficult thing. It goes back to when you have one theory replacing another theory. It's called paradigm shifts. And all in history of science, paradigm ships have been met with great, great resistance. The clearest one was the Copernican Revolution, when for 1,800 years, astronomers in our early astronomers thought the Earth was immovable in the center of the solar system. For 1,000, this was Claudius, Ptolemy, Aristotle, and the Bible, and all these Earth is immovable, and the sun and the moon and the planets all revolve around the Earth. 1,800 years. Even

Copernicus was working with these mathematical formulations. Koepp was being constantly confused until he said, what happens if we put the sun in the center of the solar system and consider the earth as simply another planet that would revolve? All of a sudden, things started to make sense. And Giordano Bruno, a theologian, was put to death for suggesting that Copernicus was right. There was a tremendous resistance on the part of the Roman Catholic Church at that time. And this is the same thing that happened when Louis Pasteur said that germs, rather than bad air, are the cause of disease. And when Darwin Wallace's theory of evolution came, it's not special creation, it's natural selection that can explain this.

These were massive paradigm changes in the history of science. And what we're seeing today is the same thing. The mitochondria is the center of the problem with cancer, not the nucleus. The mitochondria, it's a mitochondrial metabolic disease. And once you realize that, we're going to drop these death rates massively in a very number of years for sure. So if we take two paths, then if we realize that the mitochondria is the center of the dysfunction and ultimately disease in the cell, if we go down that path, what impact do you think that will have on the cancer statistics over the coming years? It'll drop it massively. Okay. I'm not going to say

we'll get rid of cancer completely. But here's the thing. We may never get rid of it, but we can learn to live with it and keep it at bay if we know that it can't survive without these two fuels. And you can do a diet and lifestyle that can restrict the availability of those two fuels and keep your mitochondria as healthy as you possibly can. What if we don't go down that path? What do you think? Then you're going to be right. One out of two people are going to be having cancer. Your statistics are going to be absolutely correct.

Is there anybody that you believe? Because, you know, when we talk about these subjects, often we think of like Big Pharma and the incentives and money and follow the money and you'll figure out why people don't want change. Is any of that sort of conspiratorial thinking correct in your view? I don't know if that's conspiracy. I don't like conspiracy terms. That's absurd.

I like what are the facts of what we're looking at. But do you see a resistance from big pharma to entertain this point of view? What do you think? Or big food? What do you think? I mean, do you think this is, I mean, you're making a lot of – not you, but people in these – and those industries, the hospital industry is making enormous amounts of money. They're awarding – we get $7 billion a year for cancer research in the National Cancer Institute, awarding many, many – not all, many grants to look at for gene mutations and all this kind of stuff. And we have drugs that are extremely expensive based on a somatic mutation theory of cancer

that are basically not dropping the death rate. As I said, while we're talking here, we're going to have 140 people dead from cancer, 1,700 people a year is getting worse and worse. As you said, we're always running for raising money for cancer research. Where's all that money going? What are you doing with all that money? No accountability.

And then when you look at the scientific advisory committee of all these societies that you're running for, they all think publish papers on cancer as a genetic disease. It's too hard for the field to accept at this point. It's too traumatic at what I'm saying. It's too disruptive to a massive industry at this time. They will come to gradually adjust to what I'm saying. It's just a matter of time because we cannot continue this trajectory. It's immoral what we're doing to some of these people.

I read a stat that said the global incidence of early onset cancer increased by roughly 80% between 1990 and 2019. That's in the BMJ oncology. Early onset cancer is basically patients under the age of 50. And when I think about this, you know, growing up in the UK, whenever there's a fun run, a charity race, a marathon, whatever it might be, cancer research gets the money. And to hear that, you know, there's been so much money invested in cancer research over the last couple of decades, but there's been an increase of 80% in early onset cancer in the same period. For me, I'm like, this research doesn't appear to be being very effective. Well, as I said, what people don't do is they never ask, where does the research go?

What kind of research? What are research go? What kind of research? What are you doing? What is the research? It's the theory that drives the impetus to do research. Now, a lot of great stuff has been done on keeping people alive that suffer from cancers, right? Because if you think about the probability of dying from a cancer, I'm assuming that has gone down.

Yeah. To some extent, it has. You know, there's two ways of looking. It's called progression-free survival and overall survival. These are the terminologies that are used in the clinical world of cancer. And they represent the approval of drugs through the Food and Drug Administration. If you have a drug that improves progression-free survival, progression-free means it looks like the drug is working on the tumor.

Because, you know, the tumor, you can see it, it gets bigger and bigger and more lethal and more lethal. And if I see it not growing nearly as much, I say, wow, look at the, it's slowing the, what we call traditional progression. Okay. It's called progression-free survival. And then you have overall survival. So you have two ways to approve drugs, mostly for cancer, right? How does it work

on progression-free survival? And how does it work on overall survival? Well, they stop looking at overall survival. Now somebody's going to bark and say, well, bottom line is mostly progression-free, which means that the patients, it looks like the tumor is being effectively managed, but they live only a couple of months longer than they would have if they didn't use this drug. So therefore, it's approved. And as opposed to overall survival, you're only living a two, OK, you've lived two and a half extra months. The tumor looked like it was managed pretty well, but your overall survival is this much, but you didn't see the tumor growing.

We're going to approve that drug. So a lot of the new drugs that we're giving do a really good job at progression-free survival, but they do a horrible job in keeping people alive much longer, which ultimately is what you want to do. You want overall survival. Let me give you an example. Avastin, Bevacizumab. This is an immoral drug that should never be used on people. It was blocked because it caused colon perforations in women

with breast cancer. They still use it on brain cancer. And so in the tumor, you get a tumor, you can see it with PET imaging. Not so much MRI and CAT scan. You can see it there. And it's looking there. Okay, you can see it. Now you give the patient Avastin, which is this anti-angiogenic drug. It's supposed to stop the abnormal blood vessels, right? They think that the angiogenesis blood vessels is driving the dysregulated growth. It's the fermentation that's driving the dysregulated growth, by the way. So all of a sudden, you give the—the tumor kind of disappears. It doesn't look like, whoa,

patient gets all excited. The physician looks and says, look at that, look at that, looks like you're doing well. What it does, the event, what the drug does is it causes the tumors to permeate your entire brain, like spreading it through your whole brain. You don't live any longer. But you had this progression free. Look at the tumor. So the patient gets excited because it looks like the tumor is disappearing with this very expensive drug. But what it does is it almost guarantees that that patient will not survive because you spread the tumor cells through the whole brain. So this is why I call it an immoral kind of a thing. But chemotherapy and sort of these radiation therapies, they have proven to keep people

alive who otherwise would have died. In some cases, it can. And that's another thing we have to look at. And I work heavily in brain tumors and glioblastomas and things like that. When you irradiate somebody's brain who has one of these tumors, you free up massive amounts of glucose and glutamine in the microenvironment. And if you look at the survival, when we did survival, looked at survival curves for glioblasts throughout the world, you can't even design experiments so consistent how fast people will die. It's like all the different hospitals have the same survival, same survival. What are you doing?

Well, we do chemo. We do surgical debulking, temozolomide, and we give steroids, which raise blood sugar, and we irradiate. We irradiate. We irradiate. Everybody's dead. So not everybody, but five-year survival is very, very low. Ten-year survival is almost zero.

But if you got a breast cancer or if you got- This is brain cancer I'm talking about. This is freeing up. Now, yes, if you have a circumscribed tumor and it's not anywhere else, you can come in with a radiation or surgical procedure and essentially cure that patient. But if you have any level of spread or anything like this, that person now- Also, if you're taking a toxic poison into your body, like red devil, doxorubicin, they call it red devil.

Your pee turns red. Everything turns red. What is that? Is that chemotherapy? Yes, it's a chemotherapy to kill a small group of cells or maybe a little bit of a spread. But your hair falls out. Your body gets brutalized by this.

And then if you survive the cancer – and many people do. We have millions and millions of cancer survivors on this planet, but many, many folks in that group suffer from the adverse effects of being poisoned or irradiated or surgically mutilated. I mean, they have to change their whole, and oftentimes the cancer comes back or they die from cardiovascular disease or they die from secondary adverse effects of being brutalized with medieval, I call it medieval, approaches to this. Are you kidding me what they're doing to cancer patients? So when we do metabolic therapy, we shrink the tumor down for sure. Then the surgeon can come in

and he sees it's smaller, fewer blood vessels because of the metabolic therapy, and we can take out a greater amount of this. And then we transition back to prevent this tumor from recurring. Metabolic therapy can be used to not only prevent the cancer, but can also be used to treat the cancer. Now, let me tell you, most hospitals, most people say, well, you know, I really want to do things to prevent cancer. Can I do standard of care before I have a tumor? What do you mean? You want to go into a major cancer clinic and have toxorubicin and radiation to your body just in the event that you might get a cancer? This is absurd. But yet when you have cancer, that's what they do to you, right? But with metabolic therapy, you can use it as both a prevention and a treatment. It's just that with the treatment, we bring in some more drugs

to target the glutamine. We don't do that on the prevention side. Omni, I was just looking at some stats as you were speaking around this five-year survival rates of a variety of different cancers over time. And it does appear that survival rates of these cancers, from breast cancer to prostate cancer to lung cancer to leukemias and various melanomas, has improved since the 1970s. So the 1970s to the

1990s to 2010s, there's been an improvement in the survival rate, which I guess is a credit to the research that's been done. What you're saying is that the treatments we have still today are horrific. Yeah, and the survivals are not that much greater. It's not like you're getting massively longer survivals. Yeah, I mean, and I haveals are not that much greater. It's not like you're getting massively longer survivals. Yeah, I mean, and I have to preface that these stats might not be right because this is AI we're dealing with here. But there's a 5%, for example, with breast cancer between the 1990s and 2010, there's just a 5% difference.

In overall survival? In overall survival. Okay, so your overall survival is two and a half to three months greater. I don't actually have those stats. No, but that's the evidence, the papers that we're looking at. So how do we prevent this then? I'm 32 years old now. So I want to make sure that I live my life in such a way that I limit my chance of cancer.

One of the things I always reflect on is the fact that many of the people that I know that have got cancer, breast cancer or other forms of cancer, appear to be remarkably healthy. Yeah, always at the beginning. Not always, but many times the person comes in, geez, I just was diagnosed with cancer. I didn't know I had it. I didn't feel bad. And then all of a sudden you get treated and they look like death warmed over. But I'm saying like, how can healthy people be getting cancer if there's this sort of central...

Well, because, as I said, and we're seeing this, I'm seeing it in my own... I'm getting more and more emails from young people in their 30s, late 20s, 30s, early 40s, like with colon cancer, breast cancer, and all these kinds of things. But look at our diet and lifestyle situation today. Those things that I'm talking about, lack of exercise, a lot of stress, poor sleep, bad food, all of this kind of stuff impacting parts of our bodies. So what do we do about it, though?

Know about it. And then what do we do? So I know now. That's personal choice. I'm not here to take pieces and jelly donuts off the market, for sure, or breakfast cereal. I love that stuff, too. But the question is, I don't eat it every day. And I know if I do, it'll kill me. So yeah, skipping meals, water only fat occasionally.

There's a lot of things you can do to keep your mitochondria healthy. Okay. So tell me what those things are. I just exercise. You look like you're a pretty healthy guy. Yeah. I go to the gym. You don't look morbidly obese to me. Not yet. Not yet. Well, that's important because you don't ever want it yet. We won't be in America too long. Yeah, well, and listen, it's not just the United States. We were kind of like the first ones to plow that field. But it's starting to spread everywhere. I think in China, they have the most 200 million obese people in China now.

So should I be on a keto diet then? Here's what we did. Okay. We developed the glucose ketone index calculator at Boston College, all right, my students and I, because we were trying to work with cancer patients, blood sugar and ketones independently of each other. And we had a ketone meter and we had a blood glucose meter. So we were monitoring ketones by itself and glucose by itself. And we worked with a very nice woman from America who lived in Nice, France, who since passed away from a brainstem tumor. It was very, very difficult. We kept her alive very long, but eventually we didn't know what we know now. But she got into an argument for a handicapped parking spot with her neighbor upstairs and her blood sugar

went through the roof. She ran upstairs and she took her blood sugar. And she says, oh my God, the tumor is going to grow. I said, what's your ketones? And she says, oh, it's still two and a half millimolar. Well, that's still pretty high. Usually it's very, very low. It's very high. So my students and I, we said, you know, this is too traumatic to try to measure these two independently. Why don't we make a singular number, divide the glucose in millimolar in the blood by the ketone in millimolar in the blood? Now you get this number that's much more stable. And it allows the cancer patient to know that if I keep this zone at 2.0 and below, my tumor

cells aren't going to be able to grow very fast. I did this for the brain cancer, right? Now it's being used for all cancers. And now it's being used for guys like yourself who just want to stay healthy. Because what it is essentially is a quantitative determination of you're in the Paleolithic zone or not. Oh, so if I'm at 2.0, like my friend Dominic D'Agostino, he's always down in these zones.

He's a Paleolithic man living in modern society. What's a Paleolithic man? That's society. What's a Paleolithic man? That's how our ancestors were during the Paleolithic period. Okay, so he's got the right balance of glucose and ketones in his blood. Like we did when we were hunting mammoths and buffaloes and these kinds of things. When we were hunter-gatherers in the thousands of years of our existence as a species, tens of thousands of years, he is in that zone. Is he in keto?

Yeah, well, that's what the low GKI is. That means you're at a level of keto. Yes, he doesn't eat a lot of carbohydrates in his diet. He eats leafy vegetables and a lot of meat and this kind of thing, sparingly on fruits. Like grapefruits, we learn from the epilepsy field, grapefruits provide a tremendous amount of vitamin C and do not spike glucose. That's very interesting. So you can have certain fruits that can keep you in this metabolic zone of pain. I call it the paleolithic zone, which is the way we evolved

when there was no cancer in our existence. When people hear that, they might start jumping on the paleo diet. I don't even know what the paleo diet is. Not a paleo diet. It's diets that are low in carbohydrates, okay? Mediterranean diets. Like people say to me, they're told, what should I eat? Should I eat this and that? Normally, you would eat foods that have very low glycemic index, which means the speed with which glucose is released, like a banana, very high in glycemic

index. You eat a banana, your blood sugar immediately spikes. Many fruits are like that. But you want foods that keep a low steady GKI. Now, I built that calculator for brain cancer patients initially. Then we realized it's powerful for all cancers. We put the cancer patient in the low glucose ketone index. We get them down in there. Then we come in with the glutamine targeting drugs to kind of polish off these tumors or put them in even a more dormant state. But now we're finding all these young kids, like yourself, all these 30, 20-year-olds,

what's the GKI? I mean, they're out there weightlifting and they're looking at their G. They don't have cancer. They're just excited to see if they can get into this paleolithic zone by themselves. And yes, that will prevent cancer. Because you can't get cancer if you're mitochondrial healthy. If you're in a paleolithic zone where our ancestors rarely have ever got cancer, then you're back in this, oh, you mean to tell me I can't eat this

and I can't eat that? What does it do to your GKI? Oh, it makes it go up. Well, don't eat that. So you did a study on dogs, a dog with a tumor. Yes. Can you tell me about that study? It was a woman came to me.

And this is what I say, you don't have to have a PhD in biochemistry to understand some of the things. This woman had no degree whatsoever. She just heard about what we did to these mice. And she did the same thing to her dog. It was a pit bull. And at age seven years old, it had a big mast cell tumor on its lip.

So she listened to my YouTube video over and over. She said to me, I just kept listening. She says, I got some raw chicken. She says dogs, wolves evolved to eat chickens. So she got some chicken, chopped up the chicken. She cut the calories. She found some dog food calculator to how much calories the dog was getting. She cut the calories. The dog lost only 5% of its body

weight. She got pollock fish oil, raw eggs, and cut all the calories. Everything was all natural for this dog. And all of a sudden, we have the pictures. You can see them if you saw the picture. Big tumor on its lip. The veterinarian said this dog is going to survive. You have to give him chemo and radiation and surgery and all this kind of stuff. And it's going to cost a lot of money. The dog's going to have diarrhea. She didn't want any part of that.

So she said, well, let's just try this metabolic thing. And she kept all the records and the pictures and what she did and how much she gave the dog and all this. So I was able's kept all the records and the pictures and what she did and how much she gave the dog and all this. So I was able to get all that information from her, put my friend Lauren Nations, who is a veterinarian, on the paper because I said, what, biology guy at Boston College is telling you how to manage cancer in a dog. We got to have some veterinarian on here to validate to make sure he's there. And he looked at the pictures and we looked at all the things.

It disappeared. So what happened was the dog eventually died of heart disease at 15 and a half years of age. So essentially, that's the only—when people say, well, metabolic therapy cured cancer, I say metabolic therapy is never considered a cure for cancer. It's an effective, non-toxic management for cancer. But in the case of that dog, it appeared to work. It's a cure for cancer. It's an effective non-toxic management for cancer. But in the case of that dog, it appeared to work. It appeared to cure the dog. But that's the only one I'll say.

Oh, he's going to say a cure cannot. That dog happened to get, he died from old age from a heart attack. And we did it with a brain tumor guy, Pablo Kelly, who just passed away, unfortunately, from a surgical, he had a major cerebral hemorrhage after his surgery from Devon, England. You know Devon, England? That's where I'm from. Are you from Devon? Yeah.

Oh, wow. Well, Pablo was there. He just passed away, fortunately. We were talking to him the day before he passed away. Pablo. Pablo Kelly. So he was from Devon, England, had a glioblastoma, which is the worst of the worst.

He's all over your newspapers there in Devon, he was always sending me articles from England. Man rejects standard of care. So he had this glioblastoma, and they took the tissue out. Which is brain cancer. Yeah, brain, the worst of the brain cancers, you know. They took the tumor out, and they said, oh, it's inoperable, inoperable. But if you do radiation and chemo, you might live nine, maybe 12 months at the most.

Well, Pablo came from a family of, like, we don't dabble in this kind of medicine. We're more holistic kind of people. So he emailed me. This was in 2014 and said, I want to try this metabolic thing. So he rejected chemo and radiation. And they said it wasn't surgically capable of being completely removed anyway. So he did this. I gave him the information that I give to everybody. And this was way back before we knew a lot of what we now know. And I said, this poor guy, he says, he doesn't want it. And they said, you're going to be dead.

They browbeat him. They try to force him to put the radiation mask on. They hacked his beard off, all this kind of stuff. And he just jumped up. He said, I can't do this stuff. So he didn't take any steroids. He didn't take any radiation. He didn't take any chemo.

He just did the metabolic therapy. And he's on English things with all of his paleo diet, which is actually a very low-carbohydrate diet. He had the avocados there. He had the fish oil there. He had this different stuff. Two or three years go by. He emails me. I said, geez, Pablo, I thought you would have been dead.

You're still alive? What's going on with that? So he calls me up, and he says, you know, I went in for a CAT scan. The doctors are like still surprised that he's alive. And they said, this tumor is still there and it's growing. And they think they can cut it out now. So he was three years on just metabolic approach. He didn't take any glutamine inhibitors, which was really remarkable. So anyway, he asked me, and I have physician friends that are radiologists that can look at it. We measured it when it was first diagnosed in 2014, and then we saw it did become a little

bigger. And now the surgeon said, I think I can get it. It looks more resectable. Here it was inoperable. Now it becomes resectable. So he took it out. And Pablo recovered really well. And the surgeon says, I think I got it all. Wow. And Pablo is measuring his glucose ketone index with our ketone monitor. So I had every day, sometimes two and three, five years of data on Pablo Kelly. Can you believe this? So anyway, Pablo thinks he's cured because the surgeon, all of a sudden he goes back to his kind of weak ways. And you can see that his GKI goes up. And all of a sudden, the tumor starts to show up again, puts the fear of God back into him, goes back on a more restrict condition. Another three years goes by. And this time,

the tumor is growing slowly, very slowly. Don't forget, glioblastomas kill you very quickly. With standard of care, you can barely get out of, at his age, if you can get two years, you're doing really good. So anyway, now he's three, and he's got six years out. And he says, you know, it's still back. You know, I've got to go in. So this is second debulking. First debulking to go in. So this is the second debulking.

First debulking goes off, gets back on. Another second debulking. Another three years goes by, he has a third debulking. Can you believe this? A third debulking. Debulking is the cutting the tumor out. It's the surgical removal of this tumor. But he's never had radiation or chemo

or any of the kinds of what we call standards of care. And now he has, I talked to him a couple of weeks ago, and he was doing really, really good. He had the third removal, and we were laughing with myself and Dr. Duryea and my associates. He says, yeah, can you imagine? I've had now three operations on a previously inoperable tumor. So we were saying, wow, they got that one wrong, didn't they, Pablo? And they kept wanting to

irradiate him and do all this stuff. And he said, no, no, going to keep doing this. And so we were speaking to him. And he's now 10 years. The tumor was diagnosed in August 2014, and he passed away August 2024. They tried to go in and get the last bit of tumor out of his brain. He came out, we talked to him, thumbs up, smiling, talking like crazy. Six hours later, cerebral hemorrhage, and he dies. So he didn't die from the cancer. He died from a surgical problem with the surgery. So he was a—you talk about long-term survivors.

You rarely survive two years with a glioblastoma. The fact that he was out 10 years, and if he hadn't had that last bit of surgery, the guy would have still been alive. Because he was talking like you and I are talking. This is a guy who has a terminal. So I said to Pablo, I said, you could outlive me. I said, we're all terminal to some extent, right? We're never, all of us aren't going to live to.

I said, he was a young guy. He was only 22 or 23 when he was diagnosed. He was in his 30s now when he passed away. 10 years, so he's 33, 34 years old. And I said, you know, I could be dead before you. And we were laughing. We had a good time. And the next thing I know, I could be dead before you. And we were laughing. We had a good time. And the next thing I know, I get an email from his wife. He said, Pablo is brain dead or something. I said, what the hell happened? What happened to this poor guy? And it wasn't

the cancer. So I don't know how long he would have lived, how many more things. But what I'm saying, oh, he's an anecdote. Well, listen, if I had a drug that did what metabolic therapy did and I could get more people like Pablo, are you kidding me? They'd be running all over the world. And when you say metabolic therapy, you mean the combination of the calorie restrictive ketogenic approach? Yes. Yeah, avoiding. Well, first of all, you're avoiding things that are going to kill you.

The radiation is going to kill you for many people. Not all people. Okay, everybody of all, you're avoiding things that are going to kill you. The radiation is going to kill you for many people. Not all people. Okay, everybody say, well, listen, you can look at the data themselves for crying out loud, and you can see how long you're going to live. He didn't do what they grab everybody in. What did he do specifically? He didn't take radiation or chemo. And he brought his glucose ketone index down to the 2.0 zone and kept it low. And he took some supplements and a few things here and there, but he wasn't really targeting the glutamine like we thought. We found now certain parasite medications will be effective in targeting glutamine.

So we're doing all non-toxic strategies to manage cancer. You don't have to be brutalized by the system if you know what to do and how to do it. The problem, the problem is most of the poor oncologists never heard of what I'm talking, the stuff I'm telling you right now, they never heard of it. The risk is someone gets cancer that's listening to this or someone has cancer that's listening to this. I mean, statistically, there's a lot of people listening to this that have cancer right now. And they're speaking to their doctor and their doctor is saying chemotherapy, radiation therapy, et cetera, et cetera. And glucose has nothing to do with the tumor. Eat whatever you want.

Yeah, and so what do you say to those people who they've just got a diagnosis and their doctors are saying, right, listen, this is pretty bad, severe. We're going to suggest that you take chemotherapy. Yeah. You're not telling them not to take chemotherapy, are you? I'm not telling them that. And what we found is that when you are in nutritional ketosis with a glucose ketone index of 2.0 or below, my colleagues that we

work with in Istanbul, Turkey, were able to show that chemotherapies at much lower dosages can be even more therapeutically powerful when you're in nutritional ketosis. So you don't have to get rid of a lot of these different procedures that we have today. I'm just saying radiation for brain cancer. I'm not saying radiation for lung or some of the other cancers. Because if you can shrink those tumors down and make them very weak and vulnerable, a surgical procedure, a radiation procedure, even low-dose chemo could come in. And even immunotherapy, if you took a big tumor and shrunk it down to a small, small nub, and it's resistant to a lot of the things, they all have to share something in common for them to survive this path. That might be an immunotherapy, but you could come in because

they're going to target whatever all of them have together, and you could possibly get rid of it that way. I'm thinking of a friend of mine that has been diagnosed with brain cancer, brain tumor. And this is one of the most, you know, it's a woman in her 40s or 50s, trying to keep her anonymous as possible, who is just the most fit athletic person that I know. Eats amazingly well, is literally known for exercise. And I'd go, how? How is it possible that someone who I would probably say is fitter than I am, if you looked at their sort of metabolic health, has got a severe brain tumor? Well, they can stay healthy for, and I'm not saying everybody who has, and it depends on what kind of a tumor it is as well. Is it a glioblastoma, oligodendroglioma, you know, peanut,

there's a lot of different kinds of tumors. Well, I know that it's not growing necessarily, but it's big and it's in the brain and they're going to remove it for a surgical operation. Well, if they can, what we always suggest for the brain cancer, if you do metabolic therapy up front, and I've had surgeons tell me this, you can shrink it down. Because one of the, it's angry, it's an angry thing, right? And you can see it down because one of the, it's angry. It's an angry thing, right? And you can see some slight invasion. If you can shrink that down so that it's more circumscribed, now the surgeon can look at it and go, oh, my God.

We know many, many scientific publications. The more you can debulk, that's called the removal of the tumor, debulking, the longer the patient will survive. The evidence is massive to support that. But with a lot of these brain tumors, you don't get it all. And there's always some little piece that remains. And when you irradiate, you explode the ability of the cells to ferment energy. And it's very hard to kill them. But if you can get the majority of it out and then transition the patient back into a metabolic state, keeping the pressure on those tumor cells,

you can remain healthy like Pablo. I mean, these guys can... And when you found in mice is that when ketogenic diet was combined with a hyperbaric oxygen therapy, the average survival time was increased by roughly 80%. Yeah, even more sometimes now. But okay, so why do we do hyperbaric oxygen, right? That's the question.

What's going on with hyperbaric oxygen? Why is this, like, a good thing? It works best when the patient and the mouse is in nutritional ketosis. Okay. So, look, we have a tumor. We irradiate that tumor. How does the radiation kill the tumor cells? It hits oxygen, blows up, and it causes a reactive ROS,

and it's like stepping on a landmine. It blows the tumor up, right? So cancer cells protect themselves. Even though they make a lot of rust, they're this close to death anyway. But they have a very powerful antioxidant system. And interestingly enough, besides causing the dysregulated growth, the glucose and the glutamine also protect them to some extent from the ROS that they're making. Can you believe this? The ROS.

R-O-S. R-O-S. Reactive oxygen species that are carcinogenic and mutagenic. So they destroy our proteins, lipids, and nucleic acids. They're disruptive molecules. So radiation will cause a ROS in the microenvironment, ROS that'll blow up and kill cells, normal and tumor cells. But if you want to selectively kill tumor cells with ROS, not to cause your hair to fall out, your gums to bleed, and all this crazy stuff,

you take the patient, you put him in nutritional ketosis, and you say he's got low GKI. Then you go into hyperbaric oxygen, which dissolves oxygen directly into your blood now. It's better than just breathing 100% oxygen, because you can actually dissolve oxygen in the bloodstream. Then you're taking away the two fuels that protect the tumor, and you're giving it internal ROS, which kills the tumor internally, only to the tumor, and you're giving it internal ROS, which kills the tumor internally, only to the tumor cell, not to your surrounding tissues. So you're killing, selectively killing tumor cells without collateral damage to the rest of your body. As a matter of fact, the rest of your cells are getting super healthy because they're burning ketones in pure oxygen.

Unbelievable. How do we measure if our… Can you believe this? I can't even believe I'm saying this stuff myself. You really got to know the biochemistry. And you have to know the physiology of your own body. And you have to understand evolutionary biology. Most people just aren't that intelligent, including me. It's not intelligence.

Most people kind of want things, sort of simple principles that they can live by. And also quick and easy. Yeah, of course. Okay. They don't want to do what I'm talking about it because it might be, oh, the other thing, let me tell you one thing and remember it. If you do metabolic therapy, success rides heavily on your shoulders. You're not sitting there like some manikin and some guy's poisoning or radiating you.

To make metabolic therapy work, you are the one doing the GKI. You're the one, It's your soul. You're responsible for your existence on this planet. You're going to put your precious soul in the hands of someone who has less of a knowledge about the problem than you might. As an entrepreneur, I'm always looking for ways to connect and to create. And that's why I decided to launch the Conversation Cards. I turned to Shopify, who also sponsored this podcast. And Shopify made it so easy to set up an online store and reach all of you, no matter where you are in the world. I remember the challenges we faced

when we first launched the Direvers CEO Conversation Cards. Managing inventory, ensuring a seamless checkout process, and reaching our audience. Shopify stepped in and made everything so straightforward and efficient. It was like having an entire team of experts by our side, allowing us to focus on creating content and connecting with you. What I love about Shopify is no matter how big you intend to grow your business, they give you everything you need to take control and take your business to the next level. And to say thank you for listening to this podcast, we're giving you a trial, which is just $1 a month,

and you can sign up by going to shopify.com slash Bartlett. The link is in the description below. Could you be predisposed genetically to cancer? Yeah, that's where those germline mutations, but you can manage that. Because people think, you know, my grandmother had breast cancer, my mother had breast cancer, so, you know.

They live in a common environment, too. It's not like you're, like, you know, to prove that, you and all the siblings would have to be raised in a different environment, different countries, different lifestyles, and then see if you all got cancer at the same time under all these different conditions. That's definitely genetic. That's like Huntington's disease, Tay-Sachs disease, or these kinds of things, where they'll manifest regardless of the environment. So you're saying to me that I should, as a 32-year-old man that's cancer-free, God willing, I think, God touch would, I should calorie restrict myself to keep my mitochondria healthy and my metabolism healthy now.

I should be in a sort of calorie restricted state. I say it's good to visit the state. Our Paleolithic ancestors had no choice. There wasn't a donut shop on every corner. There wasn't pizzas. There weren't the kinds of highly processed carbohydrate foods available to them. So should I be fasting? Should I be doing keto?

I don't want to tell you what you should or should not do. I'm not a physician here. I'm a scientist. I study what causes these things, and I study how to manage them. You have to read what I'm a scientist. I study what causes these things, and I study how to manage them. You have to read what I'm saying, and you have to come to your own decisions about how you want to conduct your life. I've given you information. What's your view on fasting?

Fasting is a powerful way to get your body into nutritional ketosis, but it ain't easy. Try doing it. You try doing it and see how easy it is. It ain't easy, right? But that's why we developed this procedure where if you go, rather than going cold turkey and say, well, today I'm going to have a big, I'm going to eat as much as I can. And then tomorrow, okay, you can go the more I can.

It's the second, third days when you start to really know what the hell is going on. And believe me, I've tried it. It ain't easy. That's why we developed a zero-carb diet for 14 days, 10 to 14 days. Just zero. You eat meat, fish, chicken, whatever you want. But just don't eat any bread, pasta, this kind of thing. On keto, how do we get into that sort of ketosis state that people often talk about? Measure your glucose-ketone index. How do I do that?

With the Keto-Mojo meter. You can buy it from Amazon. OK. OK, you can buy it. Now, don't forget they get a free Libra meter now for the blood. They're working on ketone blood meters, but it's not there yet. Right now, the Keto-Mojo or some other Keto meters where you can prick your finger like a diabetic, you take a glucose strip and you put it on the blood and you put it into the machine.

It tells you what your glucose is. Squeeze your finger a little bit more, take the ketone strip, touch it to the blood, put it in the machine. It tells you what your glucose is. Squeeze your finger a little bit more, take the ketone strip, touch it to the blood, put it in the meter. It gives you the ketone value. Push the button, GKI comes right up. Okay. Okay, very simple. Everybody can buy it from Amazon, get the meter, buy the consumables, and then they can test it. This is what Pablo, this is what all the cancer patients, the ones who really want to get into metabolic ketosis. I think I've tried keto before, and I say think because I didn't measure my keto levels. I was assuming I did. Yeah. No, it's really people say, well, I haven't eaten. I'm in keto. How do you know? Well, I blew into this thing and the bulb came on. I peed on a strip. It looked like it was

ketosis. They are indirect measures. The most accurate is the blood measure. It's hard to stay in that state for most people, right? This is one of the things. Because the temptations in our society are so strong. Yeah. I mean, Paleolithic man had no choice. Do you think he, that was his state? That's all he knew for thousands and thousands, tens of thousands, hundreds of thousands of years. That's all he knew. He didn't say, I'll may go down to get a jelly-filled donut down at the end of the river there. No, there's none of that. He had to live in that state.

Now we have so many temptations. All the things that we are biologically clear for. When you see obesity, that's evolution in action. They are the descendants of our long ancestors that could hold on to energy so efficiently. We were an energy-starved species for the majority of our existence on the planet. So anything we ate would be very little waste. We never pee out glucose. Glucose is converted to fat, and we store energy as fat.

So those guys are energy-efficient human beings. Now all of a sudden we find ourselves with everything. That's evolution in action, man. You're allowing to see how we can store energy so efficiently because our ancestors lived through such environmental forcing. We had famines. We had long treks. Our body could store energy so efficiently because it wasn't – we had to store what little we could get from the environment.

Now you've got 300 million Americans in this food environment where when they walk out their front door, they see it's a Dunkin' Donut. They can lie in bed and order a Dunkin' Donut to their front door in 10 minutes. You don't even have to un-ass the car. They can't get through the window. No energy expenditure, energy in. So giving them this information might be fairly futile because the temptation. Well, I'm not here to tell people.

Again, I'm not here to tell people what they should or should not do. I'm just here to explain, like, why do we have all this? It's not mystery. It's all biological evolution. You understand biological evolution. Almost everything that I'm talking about makes perfect sense. And unfortunately, that's not part of our scientific literacy anymore. So we need what, discipline?

Discipline is important. Discipline is important. You know, every major religion had a point of fasting to be, whether you're Islamic, Judaism, or whatever, Catholicism, Hinduism, whatever. I don't know. Whatever. They always had some sort of fasting. Why do you do fasting? Because you want to purify your body. You want to become closer to God.

You want to feel in control. And that's always part. And if you do it with prayer, it's even better. So there was a reason for doing all that. And people realized the ancients knew this kind of thing. But we don't do that anymore. We don't go 40 days without food like Jesus did in the deserts. But a human being, you could absolutely do that.

I know because I can look at your weight, I can look at your size, and I can pretty much tell you how long you can go before you died. And how do I know that? Because George Cahill, a good friend, late George Cahill, ran the Joslin Diabetes Center, and he evaluated people that would just order only fasting until death. And some of those constant maze prison camps and things. So he was able to know how much you could go. Now, what about Angus Barberi went 377 days without food. George Cahill would fast some of these obese people for

250, 300 days. What happens inside their body? They're burning fat. So what happens is you burn fat. OK, liver stores a lot of – bones store the minerals. You can get minerals from your bones. You can get a lot of fat storage. Vitamins are stored in fat, a lot of vitamin D. Outside of the weight loss, what's going on? We said religious people used to fast to get closer to God, which seems to me to point to some sort of cognitive change.

Yes, and that's from burning ketones. I said in the brain, when your brain starts shifting to ketones, your energy, the bang for the buck for each calorie that comes in from a ketone body, increases the efficiency of oxidative phosphorylation. So you're more focused? Massively.

And, you know, this is why our ancestors were the way that, if you are dependent on killing some animal for your survival and you are out on the hunt, you are focused. Because if you're not focused, you're going to starve to death. So every organ, sense organ in our body is super jacked when you're in these ketotic states. And these guys walking around with headphones, you know, all this.

I mean, this is like depriving ourselves of the natural ways of our ancestry. Don't forget, we're not just, you and I are not just here over the last, you know, 100, 300, 400 years. We are the descendants of members that are same as us, you know, hundreds of thousands of years ago. They just didn't have the technology that we have today.

But if you could bring a Paleolithic man from, say, 500,000 years ago, and you gave him a bunch of donuts and told him, oh, he went to heaven. You mean to tell me I don't have to go out and kill the elk anymore? They're going to hand me the food right through the window. Of course he's going to do that. You go in the cave and you throw a bunch of jelly-filled donuts into a bunch of cavemen who have been chewing on the half-eaten rat or something. You think they're not going to eat those jelly donuts?

They have some chimpanzees live with a family down in Florida. I know there's some YouTube thing. The chimps, they're eating the food with the family. And then they give jelly sandwiches to the chimps. They're banging on the table. You'd think they were going to go crazy. Chimpanzees loving the jelly sandwiches. Do you have kids?

Yes. What advice would you give to your children if they're listening to this now about how to prevent their chance of getting sick from cancer or these other medications? Well, they'd probably say, well, Dad, how come you don't do a lot of the things? First of all, I'm not telling – I told you I don't tell anybody what to do or how they do it. I'm just telling you the science behind why things work. Yeah, my children, my two sons, they're all very, very successful. And they said if we ever got cancer, we would be doing the metabolic therapy if we were to ever get cancer.

And I said just keep, you know, exercise and do what you can do the best you can in our environment. I mean, don't get me wrong. I mean, I'm eating a jelly donut. I'm drinking beer. I'm drinking whiskey. Why? Because I like it.

But I'm not going to be doing it all the time. You know, it's just, it's just, I'm not going to be saying, oh, I'm going to eat pizza. Sure. But I'm not going to be not doing it. I do water. I do intermittent fasting. I don't eat for 18, sure, but I'm not going to be not doing it. I do intermittent fasting. I don't eat for 18, 20 hours at a time. I do a lot of exercise over at the university, the gym, and the facilities that we have.

But I understand. And then if I were to get cancer, I would have to bite the bullet and do what I know works as much as it wouldn't be pleasurable. But it would be certainly a better alternative than being irradiated and poisoned. I'm telling you that. If that has brought your conviction to the point that you're so convinced that the real issue is this sort of metabolic dysfunction, why aren't you optimizing your life to be sort of metabolically perfect? Well, because I live in the same society you do. Yeah.

Okay. And fortunately, yes, our technology has improved significantly. You know, I'm not a monk. I'm not going to be in some monastery, you know, chanting something. I am a member of the society just as you are. And I enjoy the things that we have to offer us to make our lives a little bit more pleasurable. There's nothing like sitting down over a nice meal and having a discussion with some wine and enjoying it. Enjoy the moment, but not to be locked into that kind of diet and lifestyle all the time. It puts you at risk.

There's an election going on in the United States at the moment, Trump versus Kamala Harris. If you won the election and you became president of the United States and you had to introduce some regulations or some laws around food and all of these kinds of things, what would you do? Well, I think, you know, you're talking about a food industry. You're talking about a multidimensional economy. a multi-dimensional economy, I would not, again, you don't want government to tell you what you should do. You should make the choices. But you have to recognize, are there choices?

And what are these choices? Right now, we're not seeing or understanding how things harm people. If we have an obesity epidemic, and that would put you at risk for all these horrific chronic diseases, why do they not know that? We introduced some regulation in the UK regarding smoking, so you can't smoke inside anymore. But you see, your secondhand smoke could impact negatively the person sitting next to you.

This obese person's personal choice to be obese is not going to make you obese or sick. So this is a different kind of a situation. That has to come from internal to the person. And they have to be concerned with their own health. What about drugs, though? Like cocaine is not legal. So why can't they intervene to say you can't have Dunkin' Donuts?

Because they're both, you know, going to harm the individual. I think you'd get a revolution if you can't eat a Dunkin' Donuts? Because they're both, you know, going to harm the individual. I think you'd get a revolution if you can't eat a Dunkin' Donut. You are not going to get a revolution if you can't have cocaine. You try to go down here in Brooklyn and take away all these donuts from people. You know, you're going to see

they're going to go, you know, it's like, it's personal choices. I mean, I like Dunkin' Donuts. I mean, I like the coffee especially. But you can go to a donut shop and get some of these crullers and jelly fills and honey dipped. Are you kidding me? These things are delicious. You ever get these blueberry muffins?

You tremble when you eat some of this stuff. You know, and I'm not going to take that away from me. But if I want one, I'm not going to be, oh, every day I got to eat. No, I just don't eat it. On the weekend, I might get one. And even sometimes two or three weeks, months go by before I got to eat. No, I just don't eat it. On the weekend, I might get one. And even sometimes two or three weeks, months go by before I'll get one. But when you get it, man, you enjoy it. You really love it. Are you hopeful?

I am very hopeful. Because when the science comes, you can't suppress the truth. It's going to come out. The evidence, the scientific evidence is there. I'm documenting this scientific. And it's based on the shoulders of Otto Warburg. Are you kidding me? I mean, this was a giant in the field of biochemistry. It's not like I made this stuff up. I'm just extending what he has done to a new dimension and putting it into a practical application which he had never done.

So it's just an extension of the knowledge base over this time. Why do you care so much? Why do you care so much? Why do I care so much? You know, I'm not in it for the money. You know what I'm in it for? I want to see the scientific principles substantiated. If you know that you can keep these people alive at a higher quality of life based on the knowledge of the science that's doing that. That's gratification, man. It's gratification to know that these, because you were right

on understanding the mechanism of the problem. And if you say, you know, if we do it the way, we're writing a big treatment protocol as we speak, it's under review, a really comprehensive treatment protocol. And we institute that in the clinic. And for glioblastoma patients and these advanced cancers, they're not living a few extra months. They're living several years longer. Why? Because you knew the science. What's wrong with that? That's gratification. You don't have to make a billion dollars on that. All you have to know is that all those folks are living longer because you understood the science that was put into practical application. What's wrong? Our research is supported by philanthropy and private foundations.

That money allows me to do these experiments, to test what I'm testing on preclinical models, and then we translate it back into the clinic directly. And we see, like Pablo Kelly, he should have been done years and years ago. He lived all those years extra. He's had a wife and he's got kids. He didn't have to have his sperm frozen. He didn't have to have any of that stuff done. What's wrong with that? I'm seeing people that should have been dead a long time ago and they're still alive.

And they're saying, I'm doing fine. I get calls from people, geez, I thought that guy would have been a goner. He's still alive. He's doing well. I said, that keeps me going because it tells me that we're on the right path. This is a solvable problem. This cancer can be dropped significantly. You can take away the fear. People now put it on their shoulders. I know what to do, how to do it. I'm going to follow this. Will it work for everybody? No, but it will help a lot of people, much more than what we have today. But it's paradigm change, massive paradigm change. So they will come to know. It's just a matter of time. I don't know

how long it's going to take, but I ain't going anywhere. I'm continuing to do this. I'm going to get better and better results, and we're going to keep pushing. I've published these case reports in the scientific literature. Let the scientific field make their decision on the results from these papers. And if you are to succeed, what happens? People improve. I'm not going to live forever. But I know that what I've done with following Otto Warburg and cleaning up the misconceptions and misunderstanding of why he was stalled when the field ran off chasing genes.

We've got to bring it back on track. It's a metabolic problem with metabolic solutions. So that will help a lot of people. But it's also going to change a lot of the way people are thinking about this. But I can tell you, they want to open clinics. I get calls from Asia, Africa, South America. They want to open clinics. People are being brutalized by a system that's not working.

Don't forget, besides the terrible physical toxicity, people have gone bankrupt. Their marriages are falling apart because they can't pay for the expensive drugs on these cancer things. And they die and the bills are passed on to their loved ones. This is immoral stuff. Is there a particular case study that's broken your heart more than any others? Trudy DuPont, who originally let me, we built a glucose ketone index calculator on her. Pablo is still, we're still devastated by Pablo's loss. Because Pablo was a guy that I've known for 10 years, worked him through,

and then all of a sudden he gets a cerebral hemorrhage and dies. He was our poster child for how long you could live with a glioblastoma on metabolic therapy, but he didn't die from the cancer. You have some others that we wished they could have lived a little bit longer with the appropriate help. What I find is that sometimes within the family, there's a lot of, the guy, he says, I really want to do what you're doing. But my wife and kids say, I'm foolish to do that. So it's still a very, we're in a very early stage of this.

We haven't really worked it out into an effective standard yet. It will come. So people, and the other members of the family get super help. When they all work together and they do it, everybody says, I never felt so healthy in my life. Guy Tannenbaum had advanced prostate cancer. He wrote a book and he's on the web and he had hypertension, high blood pressure, overweight, more obesity, everything. And then he does several 18-day water-only fasts, got himself. Everything, all these things went away. His diabetes went away, his hypertension, high blood pressure, and the cancer can't be found.

So is he cured? I have no idea. But he's managed? Yes, he's managed, and he's healthier. So what's wrong with that? Isn't that ultimately what medicine wants to do, keep people alive longer and a healthier quality of life? How many more do we

need? They say, oh, that's a fluke. That's a fluke. That's a fluke. That's a fluke. That's a fluke. How many damn flukes do you want? If there's someone listening now, and I'm sure there's going to be many thousands and tens of thousands of people listening that are currently battling cancer, have early stage diagnoses. I know. I feel bad about this because people say, oh, I want to do metabolic therapy. Where can I go? And they go to their local hospital and get slapped down. There's no evidence. Everything that should come out of my mouth has never been taught to me in medical school. So what do you say to those people? You know, I say, I'm sorry that the medical establishment has not come to recognize what I'm saying.

And then I tell them, right, you know, the change has to be coming from the people. It ain't going to come from the top medical schools. They are doing what they're doing. The status quo is very profitable. The status quo is very effective for these people. But it's not helping the cancer patient as well as it can. And don't forget, we're not throwing out all this stuff. We're just asking people to know how to use the tools we have

in a better way. We don't have to throw out immunotherapies, radiation. We don't have to throw out toxic poisons. We just have to know better how to use it when the patient is in this new state. And the data will prove it. But who's going to do that? Who's going to do that? The doctor says, I'd love to do this, but I'm going to lose my license if I do it. But who's going to do that? Who's going to do that? The doctor says, I'd love to do this, but I'm going to lose my license if I do it. What's going on with that? They wrote the standard of care as if it were ingratiated. It can't be changed. No, it should be flexible. When new evidence comes up, I don't believe your evidence. What number do you not believe? What piece of science do you not believe on this? Well, I haven't read it. You can't be right when

99% of the world says it's this way, and you're saying it's something different. That's confirmation bias. You're not looking at the numbers. And then when they get cancer, you come to, hey, what can you do for me? It's like that. But yes, it has to change. It will change, because we're on the momentum to move it. People are coming to know this. And once the change happens, it's going to be like a major, major change. And people are going to have to just readjust. Thomas, we have a closing tradition on this podcast where the last guest leaves a question for the next guest, not knowing who they're going to be leaving it for. And the question that's been

left for you is, imagine the end of your life. Your closest friends and family are at your funeral. What do you imagine or hope they say about you? He changed the course of cancer treatment for the world. It, that's it. Dr. Thomas Seyfried, that is exactly what you're doing and i think that's a really extremely you know i can't even find a word that describes the profundity of such a mission um because so many people are struggling with cancer as if it is this sort of opaque black box of a disease that strikes us at random and picks on people like roulette and debilitates their lives out of the blue.

And having more information out there about the root causes of these issues turns the lights on and allows us to go in search of better solutions to what has always been a really, really complex, hard-to-understand disease. Your work runs almost entirely, I believe, on philanthropic donations, right? That's right. So that's people that... They make donations to both my university, Boston College, which is a Jesuit university in Chestnut Hill, Massachusetts. And we follow the Jesuit philosophy of service to others

predominantly, and private foundations. So if someone wants to make a donation, where do they go? Do they go to your website? I know there's a donation button there. They go primarily to our university. They can just, they have a, on my university biology webpage, there's a donation button. And Travis Christopherson's Foundation for Metabolic Cancer Therapies,

which is a 503 foundation. He supports our research through philanthropic donations to his foundation. I would urge anyone that wants to support your mission to go to your university website. There's a donation button there, which I saw earlier on. Click that button and they can make a donation. That's right. And that and Travis Christopherson's foundation, which is the Foundation for Cancer Metabolic Therapies. It's a 503 foundation, Travis Christopherson's. When people email me, I send them the links to those foundations. I cannot accept personally any money from anybody.

Okay, that's one thing. That's one thing. I'm not here. So people say, oh, I want to give you money to do it. No, no, no. I can't. You have to give it to the university to come through me through the appropriate channels to support my research through the university.

Dr. Thomas Seyfried, thank you so much for your time today. And I'm hugely inspired and enlightened by everything we've discussed. And I think there's a bunch of very straightforward practical things I'll be implementing in my life, specifically buying one of those bloody machines so that I can keep on my GKI index. Yeah, glucose ketone index. Well, listen, thank you very much for having me here because your programs and others alert people to know that there are alternatives, effective alternatives. And once the system changes, the outcomes will not be so bleak as we currently have them today. Isn't this cool? Every single conversation I have here on the Diary of a CEO, at the very end of it,

you'll know, I asked the guest to leave a question in the Diary of a CEO. And what we've done is we turned every single question written in the Diary of a CEO. And what we've done is we've turned every single question written in the diary of a CEO into these conversation cards that you can play at home. So you've got every guest we've ever had, their question, and on the back of it, if you scan that QR code, you get to watch the person who answered that question. We're finally revealing all of the questions and the people that answered the question. The brand new version two updated conversation cards are out right now at theconversationcards.com.

They sold out twice instantaneously. So if you are interested in getting hold of some limited edition conversation cards, I really, really recommend acting quickly.