The Dr. Hyman Show - Can You Age Backwards? with Dave Asprey

Episode Date: October 9, 2019

Getting older is inevitable, but aging is not. What society thinks of as aging—wrinkly skin, poor memory, weight gain, aches and pains—is actually abnormal aging, and it doesn’t have to be this ...way. There are reasons for these symptoms, and when we tap into the root cause we can prevent and even reverse them and feel youthful despite our age. We can do that using the principles of Functional Medicine, as well as the power of biohacking our biology.  My guest on this week’s episode of The Doctor’s Farmacy is an expert in biohacking and reversing the aging process. My good friend Dave Asprey is the founder and CEO of Bulletproof 360, creator of the global phenomenon Bulletproof Coffee, a two-time New York Times bestselling author, the host of the Webby award-winning podcast Bulletproof Radio, serial entrepreneur, and global change agent. By employing the principles of biohacking (a term added to the Merriam-Webster Dictionary in September of 2018 with Dave’s influence) Dave has lost over 100 pounds, upgraded his brain, learned to sleep more efficiently in less time, and become a more effective entrepreneur, husband, father, and overall human being. In this episode, he shares his top tips and tricks for being superhuman and living to be 180 or beyond.  This episode of The Doctor’s Farmacy is brought to you by ButcherBox. Now through October 15, 2019, ButcherBox is offering listeners of the podcast 2lbs of wild-caught Alaskan sockeye salmon and 4 grass-fed, grass-finished sirloin steaks for free in your first order PLUS $20 off your first box. Just go to ButcherBox.com/farmacy to take advantage of this great deal.

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Starting point is 00:00:00 Coming up on this week's episode of The Doctor's Pharmacy. Get an older friend if you're young, get a younger friend if you're old, and that's one of the simplest things you can do to live longer for both people. Hey everyone, it's Dr. Mark Hyman here. Now I'm always being asked how to source high quality meat and seafood. So I want to share one of my favorite resources with you that I use to get high quality protein in my own diet. Now, unfortunately, most meat and seafood at the grocery store is not serving our health or the planet for that matter. Conventionally raised animals have higher levels of inflammatory fats, not to mention all the antibiotics, hormones,
Starting point is 00:00:37 and other harmful compounds that we just should not eat. And the seafood, well, that can be full of heavy metals and other toxins or just lacking nutrients in general because they're farm-raised. And don't even get me started on the environmental and the inhumane aspects of conventional meat and seafood production either. That's another huge issue that we can improve by shopping more consciously. And that is why I love ButcherBox. They make it super easy to get humanely raised meat that you can trust by delivering it right to your doorstep. ButcherBox has everything you could want, like 100% grass-fed and grass-finished beef, free-range organic chicken, and even wild-caught Alaskan sockeye salmon, and shipping is always free. Now,
Starting point is 00:01:26 ButcherBox is committed to humanely raised animals that are never given antibiotics or hormones, and since they take out the middleman, you get extra savings. This is a major stipulation I always tell my patients about when it comes to animal protein. Quality needs to be a priority, and with ButcherBox, you can really feel good knowing you're getting the highest quality meat and seafood that will help you thrive. And right now, ButcherBox has a special offer and you can try the best of both worlds and get two pounds of wild-caught Alaskan sockeye salmon and four grass-fed, grass-finished sirloin steaks free in your first order,
Starting point is 00:02:05 plus $20 off your first box. Just go to butcherbox.com forward slash pharmacy. That's F-A-R-M-A-C-Y, butcherbox.com forward slash pharmacy. And make sure you order between October 1st and the 15th, 2019, to take advantage of this amazing deal. I promise you'll see why I trust them when it comes to my own diet. For those of you who know me, you know that I love to cook and spend time in the kitchen. It's truly a revolutionary act, and in fact, it's the gateway to your best health.
Starting point is 00:02:40 I tell my patients that to enjoy and appreciate cooking with real foods is the best way to regain their health, which is why I'm coming out with a new cookbook called Food, What the Heck Should I Cook? My team and I put together this cookbook with over 100 delicious recipes from real food. I think you're going to really love it. And if you want to learn more about it, just go to foodthecookbook.com right now. Sign up and get the free video instantly in your inbox of five steps to conscious cooking that I created to guide you through how to cook in your kitchen, all the secret tips I use.
Starting point is 00:03:13 Or if you know that you really want to own the book, you can actually pre-order it right now. So when you pre-order and you show your proof of purchase, you're going to get really great bonuses, including four cooking videos of me personally and you show your proof of purchase, you're going to get really great bonuses, including four cooking videos of me personally cooking some of the best recipes from the book. You'll get a recipe ebook with exclusive bonus recipes. And you're going to get so many special offers from my favorite merchants, things like Vitamix, Wayfair, Thrive Market, and lots more. I'm so excited for you to check out my new book.
Starting point is 00:03:46 So just go to foodthecookbook.com. Thanks, and I'll see you in the kitchen. Welcome to The Doctor's Pharmacy. I'm Dr. Mark Hyman, and that's pharmacy with an F, F-A-R-M-A-C-Y, a place for conversations that matter. And if you want to live long and be superhuman, then this conversation matters because it's with my close friend, a brilliant biohacker, one of the leading thinkers in medicine and health today, Dave Asprey, also known as the Bulletproof Guy, who was the inventor of Bulletproof
Starting point is 00:04:19 Coffee. I'm sure you've all heard about it. It's the latest, hottest thing. He's the founder and CEO of Bulletproof 360, which is the global creator of this phenomenon, Bulletproof Coffee. He's a two-time New York Times bestselling author. He's the host of the Webby Award-winning podcast, Bulletproof Radio, which I've been on a couple of times and soon to be a third.
Starting point is 00:04:39 He's a serial entrepreneur. That's S-E-R-I-A-L, not serial, because I wouldn't have him on the podcast he was making cereal yeah he's a global he's a global change agent he's dedicated two decades of his life to identifying and working with world-renowned doctors including me scientists scientists luminaries of human existence i don don't know who those are. Innovators to uncover the most advanced methods for enhancing mental and physical performance.
Starting point is 00:05:12 Dave's discoveries and the companies he founded offer tools that enable people the opportunity to take control of body, mind, and biology, elevating human performance far beyond what we ever dreamed possible. By employing the principles of biohacking, a term added to the Merriam-Webster Dictionary in September 2018 with Dave's influence, congratulations, Dave has lost over 100 pounds. He's upgraded his brain. He's learned to sleep
Starting point is 00:05:39 more efficiently in less time, become a very effective entrepreneur, husband, father, and overall human being. And I've known Dane for many years, and I keep seeing him becoming a better human being every time I meet him. He's happier. He's funnier. He's cuter. He's awesome.
Starting point is 00:05:55 He's been featured on so much media, like the Today Show, CNN, CNBC, Nightline, Dr. Oz, The Steve Harvey Show, and lots more. His impact is really felt on a global scale. He's a true game changer and a maverick. And I am honored to have Dave be a close friend and a mentor and a teacher. I learn more from him than I do from most medical textbooks. So, oh my God, it's so awesome. It's so awesome to have you on the podcast.
Starting point is 00:06:21 And we're going to talk today about something really important. The title of your new book, Superhuman, the Bulletproof Plan to Age Backward and Maybe Even Live Forever, is quite a claim. Now, I once was talking to you that I want to live to be 120, and you're like, why only 120? I want to live to be 180. And I'm like, okay, I guess I could set my sights a little higher, but it just doesn't seem realistic. But you've written this book that brings together some of the most exciting new research about how we age and how we can un-age, literally reverse aging. And you go into such exquisite detail with such great examples and bring in things that most people really even haven't heard about, things like ozone and NAD and mitochondria.
Starting point is 00:07:03 So I want to really get deep into this with you. So welcome, Dave. Mark, I love getting to hang out with you and spend time with you. And that was an amazing introduction. So I learned an equal amount from you. All right, here we go. So when I learned about aging, it just seemed like this inevitable process of disease. And what I learned very early
Starting point is 00:07:25 on in functional medicine was that getting older is inevitable but aging is not necessarily inevitable that what we think of as aging as normal aging in our society is the result of abnormal aging and i recently did my telomeres i'm going to be 60 this year and did my telomeres. I'm going to be 60 this year. And in my telomeres, I'm 39, which is pretty awesome. And biologically, I'm younger because I do the things I need to do to take care of myself. So, you know, I'm six years old, but I'm water skiing, I'm climbing up mountains, I'm doing all kinds of stuff that I was doing in my 20s and 30s and feel fine. So I think it's really an interesting question about what are those things that cause us to see this abnormal aging?
Starting point is 00:08:14 You call them the four killers. So what are those four killers that will most likely kill us as we age? It turns out this is going to be really amazing for a director of functional medicine at the Cleveland Clinic kind of guy. But the first thing you do if you want to live a long time is don't die. It's kind of obvious, but if you're an average person and by the way, you're not average if you're listening to this episode, because you have all the access to the knowledge of doctor's pharmacy, which is really a game-changing thing for you. But something's going to kill you. In fact, let's play the odds. It's probably heart disease, diabetes, cancer, or Alzheimer's disease.
Starting point is 00:08:57 In fact, those add up to somewhere around 80% of the likelihood of things that are going to get you. So what if you could cut the odds of those happening to you radically? Well, a couple of things would happen. One, you'd have a higher quality of life, however long it was. So that picture of aging that we all have, which involves wheelchairs, diapers, not knowing your own name, tubes, like it's a pretty horrific horror movie sort of picture that most people have. And that's why they say it depends, right?
Starting point is 00:09:31 I wouldn't want to live that long but what if what if when you were a hundred you felt like you did now you looked like you did now a few more wrinkles maybe a few more wrinkles but you would also have a few more decades of wisdom and i think we have an epidemic of of absence right now because throughout all of history, when you aged, you were venerated and you were the village elder. People came to you for advice because you probably went through it before. Now they stick you in a nursing home. Well, not only that, you're probably, you don't remember a lot of this because your brain is fried by eating bad fats and grains and not taking care of yourself. It's not that you did that on purpose. It's because we built a food system that does that to you.
Starting point is 00:10:09 So what if you had this picture of being fully independent and full of energy and able to share knowledge and give back and get to know your kids, your grandkids, your great grandkids, and just be of service to your community. And at that point, suddenly aging is different and there's nothing that says you know i'm 142 and i've done everything i came here to do and
Starting point is 00:10:31 it's time for me to go fine but at least my real goal mark i would like to die at a time and by a method of my choosing yeah there you go right and if you want it to not be up to you like i'm not ready to go okay well there you kind of did something wrong. Or even worse, I'm dying of whatever disease, right? And you could have done something that didn't cost you a penny, that wasn't unpleasant, you just didn't know what to do, right? And it's those things that I'm looking to change. Yeah, it's so powerful. So in the science of aging, we know a lot now. We know a lot about what causes aging. We know a lot about what causes aging. We know a lot about the mechanisms.
Starting point is 00:11:07 And in functional medicine, there are fundamental laws of nature that we follow in order to create vibrant health. And there are systems in the body that are all networked together that determine the quality of your health or will determine disease. And two of those, well, many of them, all of them, in fact, are connected, whether it's the microbiome or your hormones or your detoxification system. But two of the central features of aging are inflammation. It could be called inflammation, right?
Starting point is 00:11:39 And the mitochondria, which for those listening, those are the little powerhouses of your cells that produce energy. When you eat and you breathe, you basically combust them like in an engine and these little tiny things inside your cells that produce energy in the form of ATP. That is the central quality of your health, which is the quality of your mitochondria, the quality of your health depends on the quality of your energy. And so those two things are things you have written a lot about. And you know a lot about, and we know a lot about what makes those systems go awry and how to fix them. So can you talk a little bit about that?
Starting point is 00:12:16 Diabetes is a disease where your cells can't use food in the form of glucose and air to make energy. It's a mitochondrial dysfunction, a metabolic dysfunction disease. And that disease raises your risk of cancer and heart disease and Alzheimer's disease. Yeah, four times the risk if you have diabetes that you're gonna get dementia. Exactly.
Starting point is 00:12:36 So could it be that all four of the killers are all tied to metabolic dysfunction, which is tied to mitochondrial performance? It turns out it is. It also turns out that your body has all these amazing repair systems that you can turn on that have been there always that are probably not turned on. And every one of those repair systems is dependent on functioning mitochondria. So when we look at these seven pillars of aging, one of the first ones is mitochondrial mutations.
Starting point is 00:13:08 These mitochondria, they're ancient bacteria that are a part of our cells now. They look like little bacteria if you look at them in a microscope. And they have their own DNA. That's bacterial DNA. And so you could say that, oh, we harnessed them. But from their perspective, we found these mobile Petri dishes that walk around and do stuff. And we're the puppet masters. And if we don't like what's going on we just make less energy and then they feel crappy then they do what we want so literally they're driving a lot of the the reason that you just unconsciously reach for the cigarette or you reach for the donut it's because your mitochondria is saying i need food right now and they're talking to you and then you find the donut in your hand or you told yourself you weren't going to smoke today and you did who's pulling the puppet strings those little bastards are so
Starting point is 00:13:49 yeah let's get those no we don't want to get them we want to help them you do want to help them because when they're happy you're happy and that includes eating the right stuff it includes sleep all the the good stuff that you talk about on your show mark Mark. However, they mutate relatively easily. So they're easily damaged. Yeah. Right. They're easily damaged. And your job is to teach your body, you know, if one of them is damaged or slow, kill it all the way and replace it with a fresh young one, because we have that ability. But if you eat too much, eat too often, eat the wrong things, don't do the other things that don't cost much, if anything, then the systems that... Like exercise and sleep and... Yeah, you know, things like that. Yeah. Really basic stuff,
Starting point is 00:14:32 to be honest. But if you do them at the right time or in the right way with a little bit of structure around them, what happens is the old weak mitochondria get out of the way and make space for young ones. And when that happens, all of the other repair systems can turn on. And there's other things you can do. People don't know this, but we have something called zombie cells that I write about in superhuman. And what a zombie cell is, is a cell just like a real zombie. It sits there and it's not dead really, but it's not alive really either and it sits there makes free radicals it takes up space and it does nothing good for you but it it adds to your metabolic burden so what do you do well these are called senescent cells in the aging field and there are things you can do to encourage
Starting point is 00:15:17 your body to get rid of senescent cells and they range from something higher pac-man to come and clean them up yeah that's pretty much. We have little robots that come in. And there are people who actually want to make little nanobots and stuff. Unnecessary. The body is such a beautiful, elegant thing. It wants to live a long time. It wants to repair itself. But it's going to make a decision.
Starting point is 00:15:36 Let's see. Donut, self-repair. And if you let the body decide without intervening, it's going to pick the donut every single time. You know why? Because throughout all of human history, there have been regular famines. And if there's a donut, it's a good idea to eat it in case there isn't a donut tomorrow. And you know better.
Starting point is 00:15:52 We all know better. But we evolved in an era where there wasn't Krispy Kreme or Dunkin' Donuts in every corner. So yeah. And our cells don't know that though. They're still stuck in that. So they will self-sacrifice. They'll turn off their ability to save energy to take care of themselves for the donut. So this is just about knowing,
Starting point is 00:16:07 oh, if I brush my teeth, I'm better off. I don't get cavities. There are basic metabolic maintenance things that I read about in Superhuman that we haven't been taught to do. Yeah, it's pretty interesting. You know, when we look at all the things we do know about aging, right?
Starting point is 00:16:19 And all the interventions that seem to turn off aging and turn on you thing, let's call it. She wrote a book called You-Thing. That's a great name. Okay, that's good. It's fascinating. And it's the things that are showing up in the science now, whether it's calorie restriction.
Starting point is 00:16:40 The only thing that's been shown to increase longevity reliably in animal models is restricting calories. You eat less by a third, you live a third longer, but you're miserable. So I don't want to do that. Then there's what we call intermittent fasting, which most people mean by that time-restricted eating where you eat an eight-hour window. Then there's true intermittent fasting, which may be fast a day or two a week. And then there's fasting-mimicking diets and there's ketogenic diets. All of those activate the same thing, which is this process of self-repair and healing that is a natural thing that our body does, but that we interfere with all the time by just eating all the time and eating all the wrong foods all the time. And your book really goes into how do we reverse that process?
Starting point is 00:17:21 How do we understand what harms the mitochondria? What caused inflammation? How do we shift that? So let's talk more about these cellular aging forms, cellular aging processes that drive disease and that you talk about as being the cause of aging. So these seven pillars of aging. You mentioned the zombie cells, but let's go through the other ones. Another one that's really interesting is called cellular straitjackets in superhuman. And people have usually by now heard of something called amyloid plaque, or usually it's beta amyloid plaque because people say, oh, that's what causes Alzheimer's disease. It's actually not what causes Alzheimer's disease. It's a symptom of it.
Starting point is 00:17:59 But it turns out amyloid throughout the body forms and is a contributing cause of aging. So if you were to say, oh, I fixed my mitochondria, but I have amyloid everywhere, you're still going to show signs of aging. You're not going to have maintained your youthfulness. That's why there's these seven pillars that support you. It turns out inflammation causes it. It's the equivalent of having a callus or a scar over time. So amyloid plaque in the brain, chronic brain inflammation, which is caused by mitochondrial dysfunction in the brain. But you can have this in your bicep. You can have this in your endothelial cells. It can happen throughout the body and it builds up over time. So when you start saying, I'm going to live twice as long as mother nature wants,
Starting point is 00:18:38 you're going to have to do something about this. Otherwise, half your body is going to be amyloid plaque and you're going to be walking around like a piece of bamboo, not like a flexible human. So how do you get rid of this bamboo? Well, there are a variety of new enzyme formulas that are just about to come on the market that scientists have been working on the anti-aging field that can break these down. In the meantime, though, how about this? What if you actually didn't build them up because you addressed inflammation? Yeah. Okay, what caused inflammation? Well, what causes inflammation?
Starting point is 00:19:09 How do you get rid of it? Every single time there's inflammation, it is ultimately coming from your mitochondria. And there are things that signal inflammation to happen in the body. And things called inflammatory cytokines. So one of the things you do is you find the habits you have every day that trigger inflammation and you stop doing them. Like? Like eating grain, eating bad fats, eating anything fried in any oil.
Starting point is 00:19:38 Sugar. Oh, no, sugar is good for you. I'm eating. All right. I think this podcast is over now it's actually a gluten deficiency that we're all suffering from mark no gluten deficiency lack of sugar i don't know if ice cream i think that's the key to everything it turns it turns out if someone was to have three grams of sugar with their meal if they have a healthy metabolism, it will do nothing to them. But three grams of an inflammatory oil, a damaged oil,
Starting point is 00:20:08 what does three grams of fish oil do to you? A lot. A lot. What is three grams of highly oxidized fried oil going to do? It's going to do a lot in the wrong direction. So it turns out sugar, if you're on a high sugar diet, especially liquid sugar, it is going to wreck your gut bacteria and gut bacteria are a part of the aging puzzle. So I would say though, bad fats are more dangerous
Starting point is 00:20:31 than sugar and you don't want to eat either one of them. But you know, if there's a teaspoon of sugar in a normal meal on occasion, it's a lesser evil. Yeah. It's not that it's the pharmacologic doses that we eat of, you know, 150 pounds a year per person. That's the problem. It's a lesser evil. Yeah, it's not that. It's the pharmacologic doses that we eat of 150 pounds a year per person. That's the problem. It's horrifying, right? It's not the sugar you put in your food. It's the sugar added by all these companies that do this process. You're 100% correct.
Starting point is 00:20:54 And there are a group of people say if you eat a single carb, you're a bad person. I like to call them the keto bros or dirty keto. And what's going on there? Okay, it turns out your gut bacteria. The keto mafia? yeah oh good one your your gut bacteria they must have soluble fiber which is a carb yes like i manufacture soluble fiber i intentionally put it in my body i in in the book i actually talk about the number of gut bacteria species that i had it was 48 because i travel 150 days of the year i cannot
Starting point is 00:21:24 eat enough vegetables at restaurants. Well, I quadrupled it. I put two scoops of the inner fuel, a prebiotic mix of plant fibers, and I put it in my coffee and now I'm at 196 species. And I didn't have to eat kale. I didn't have to smell kale.
Starting point is 00:21:41 Wait, are we on an anti-kale kick now? Absolutely. Kale is bad. what what's going on around this inflammation in our cells that causes these cellular straight jackets is look if you eat some fried stuff oh i just it's a special treat i just eat it a couple times a week it it constantly grates on your system it's going to take four days to get rid of all the inflammatory compounds from that and you do that for 20 years and all of a sudden your cells are walking around with less flexibility and way more amyloid we are eating a inflammatory mitochondrial damaging diet yep is our main diet and it is what we talk
Starting point is 00:22:15 about all the time it's it's it's something that is just so pervasive and that it unfortunately is so easy to get oh yeah whereas like you said you're on the road it's hard to get vegetables i literally go to a restaurant i'm traveling i'll say can i please have three sides of vegetables you know like and you know what comes four four string beans yeah four string beans and they're all deep fried in like some kind of batter the worst was when i was in des moines iowa doing a public television show and and i was like in the hotel i wanted some food i'm like all right can i get some vegetables because i'm like well we have green beans and i was like in the hotel i wanted some food i'm like all right can i get some vegetables because i'm like well we have green beans and i'm like okay so they brought green beans and they they were canned green beans they were soggy and gross and they were covered with this brown sugar gravy oh like like a soup of gravy over the green beans
Starting point is 00:23:01 and that was the vegetables in there wow did you wash them off with coca-cola i just didn't know what to do i was like i was like oh what a vegetable it was terrible but i said i said okay is there a chinese restaurant around here and then there was and i went there and they actually had a lot of veggies as long as they're steamed a lot of times you go to a chinese restaurant they fry a lot of funky oils And funky oils. So you get the funky oil. The steamed broccoli, right? And people might say, Dave, you and Mark, you are so picky and extreme. But here's the deal. If you eat no fried food for the next two weeks and you look at your skin and you look at how you feel when you wake up and you look at your grip strength and you look at every single metric about how good you're doing, you will improve. But I like fried food.
Starting point is 00:23:44 Look, you can also say, I like heroin. So, but I like fried food. Look, you can also say, I like heroin. I don't care. Don't use it. It doesn't matter if you like it. It's just not okay. And my kids know that. And I've taken my kids out and said, all right, let's go eat serious junk. So they can feel it. All right. So we've talked about the mitochondria mutations. We talked about the cellular straight jackets. We talked about the zombie cells. Let's talk about age. Yeah. Advanced glycation end products. It turns out two of the other pillars of aging are buildup of extracellular and intracellular junk. It turns out inside your cells, there are some compounds that your cells are supposed to be able to burn up and get out. So every cell has something called a lysosome inside it, and its job is to burn up extra protein and use it for energy
Starting point is 00:24:31 so that you can break it down into its components and get rid of it. But we eat things, and we sometimes over time generate things in our bodies that our lysosomes can't break down. It's sort of like you have an incinerator at the dump, but you stick enough things in there that won't burn. It can sort of like you have an incinerator at the dump, but you stick enough things in there that won't burn. It can't function in there. And then you get a big pile of stuff at the dump. So what do we do about that? Well, the easiest thing is make sure that you eat less of the things that cause those things to back up. You know, they're called ages, advanced location
Starting point is 00:25:02 and products. It's sort of like, you know, the crust on a bread or the crispy skin on chicken. It's like the creme brulee, that crispy thing. That's basically proteins and sugars forming a compound that accelerates aging. It's literally called ages and they bind to receptors called rages. You can't make this up. Advanced glycation end products. It's basically sugar and protein combined together that create this massive inflammatory response and oxidative stress, which then damages your mitochondria and creates this vicious cycle of aging and disease. You nailed it. It's funny, when I wrote the Bulletproof Diet, which came out in 2014,
Starting point is 00:25:40 but it was based on about a decade worth of experiments before that i wrote you don't want to eat ages advanced glycation end products because i could feel the difference in my inflammation when i ate them i knew that they weren't good because i was fat and old when i was young so i reversed that but i'm a good canary and i cited a couple studies but we also make advanced glycation end products in our bodies when we eat sugar yeah so you eat these huge doses of sugar the sugar courses through your body looking for proteins to stick to and it will do that but in in superhuman i cite new research where we talk about the effects of eating advanced glycation end products versus making them on you know the best way to eat them
Starting point is 00:26:20 microwave your food oh microwave your food and caramel, which is pretty much solid advanced glycation in products. Caramel? Oh, my God. Don't tell me that. Sorry. Caramel is my favorite. It's so good, but you're taking milk and sugar and just cooking and cooking and cooking and cooking
Starting point is 00:26:34 until it's a brown sticky. You're ruining my life, Dave Asprang. You can make caramel that tastes the same out of plants. All right, I got it. And burned meat is a really big thing when you barbecue it so what these are these burned vegetables feeling oh grilling meat grilling grilling your vegetables does the same thing as grilling meat it creates the same toxic chemicals i go to restaurants to say i like a plate of broccoli and they bring me a plate of blackened broccoli like you ruined it
Starting point is 00:27:02 right you don't do that so less stripes and less charring i go to a place i only eat grass-fed pastured animals or i don't eat it eating industrially raised antibiotic corn and soy fed animals is a great way to age quickly but i'll go there and i'll say please don't char my steak like cook it gently i still want to meet your mirror low cooked meats yeah dutch oven is my new favorite thing so good you put the stuff in there you put some vegetables and tomato sauce whatever you put in the oven for three hours come back and it's like magic and it's done julia child it comes out it's like it's ready i do a lot of something called sous vide because i'm lazy so you you ziploc your your steak or whatever in a thing put it in a water broth with a little temperature thingy and you come back 24
Starting point is 00:27:44 hours later and no matter what cut of meat it is it's perfectly tender and medium rare and and it takes almost no work yeah and so wait did i save time and get a higher quality food that tasted good because here's the deal in superhuman in the bulwark diet in your work we are talking about eating foods that are more satisfying more delicious and more tasty to the point that if someone puts a piece of you know in big big pharma or big food birthday cake from some commercial bakery versus something that you would recommend or i would recommend you'll look at that you'll say that one's pretty but i want to eat the thing that tastes really good and nourishing and satisfying and your body will actually guide
Starting point is 00:28:21 you to the good stuff yeah you know i've noticed I've noticed that. I mean, over the years, you know, I used to eat more junk and crap when I was younger. Yeah. And now if I like walk through like, you know, a Starbucks case full of all this stuff or I go in some restaurant, it doesn't look like food to me. Yeah. It's like, why would I eat that?
Starting point is 00:28:39 It's like a rock. Like, I'm not gonna eat a rock or a piece of wood, but like, it doesn't actually look like food to me anymore. And I don't crave it. I don't want it. It's not like I'm depriving myself. I just literally don't actually have an interest in it. And it doesn't actually look appealing to me.
Starting point is 00:28:55 And it doesn't even, I don't even think it'll taste good. And when I, if I do taste it, it's like, ugh, I want me to eat that. I, I'm with you there. And people think it's a little bit crazy. Cause I remember when I weighed 300 pounds I would have the worst cravings and you'd see those those scones or whatever in the the case at the coffee shop and you're like oh I really want that and you walk past it would just call to you those are your damaged mitochondria desperate for energy going you know please please eat that
Starting point is 00:29:19 please eat that and it's same thing now in my pattern matching system those don't register as food anymore because they're actually not food for humans right and now that my pattern matching system is right i just like like you said if it could be a rock it'd be a cactus but you wouldn't put it in your mouth right so therefore the willpower it takes to do it is gone it's not like i don't it's not a willpower thing anymore once you not at all once you rewire your hormones and rewire your brain chemistry your body will actually want the right stuff it actually will like it now here's the thing you have a kind of outrageous claim you're kind of an outrageous guy and let's talk about why that's not outrageous and your outrageous claim is you want to live to be 180 yeah now i
Starting point is 00:29:59 don't think well maybe methuselah but maybe some guy who no birth certificates that claims he lived to be 180 i don't know but but you don't want who no birth certificates that claims he lived to be 180 i don't know but but you don't want to really just live that long you want to have a great life you want to have better sex super brain power you want to not get sick so tell us your secret plan which is not so secret because you wrote about in superhuman for aging backwards that will add more years to your life and more life to your years all right i want to know that i'm taking notes first i'm going to tell you why 180 is a real number and then i'm going to tell you that okay okay because i'm buzzing your job but i i'm like
Starting point is 00:30:35 curious i'm like all right okay okay so then all your well you better live that long because then at least have one friend yeah absolutely we'll be hanging out everybody's gonna be dead we're gonna like just gonna be you and me i don't think it's gonna end up like that a lot of people listening to the show are gonna live decades longer than they think yeah and i want you to to go back a hundred years mark okay if if you're gonna live to 150 you've got 90 more years if i lived 180 i've got 136 more years but let's go back 100 years. Here's 1919. World War I is ending, where many of the battles are fought on horseback.
Starting point is 00:31:12 Yeah. Look at where technology has taken us today. Yeah, look at it. It's kind of scary. Yeah, well, you look in 1950, end of World War II. If you were the president of the U.S. and you wanted wanted some research done there were massive armies of people with card catalogs who'd go out and do research and six months later they'd do something you and me and everyone listening to your show today can go online for free in half a second and search pubmed which is pretty much all of the medical knowledge
Starting point is 00:31:41 that we have yeah all the scientific papers you and i had to do micro fish half the people listening don't know what a micro fish is right this is by the way it's like a photocopy on a tiny little piece of transparent plastic and you go to the library and check one out in an envelope and put it on a weird little viewer screen that would amplify it i'm not even making this up this is a real thing you remember it and then you'd fax it to someone too right like that was that was actually before fax. That was way before fax, right? But all of these things have happened.
Starting point is 00:32:09 And by the way, a fax machine is one of those things you put paper in and it transmits it in a weird way that comes out on the other end with a piece of paper. It's like kind of an old technology. Let's see if some people don't know what a fax is anymore. But I asked someone to fax me something. They're like, fax? What?
Starting point is 00:32:24 They still do fax? I'm like, yeah, they do fax for medical stuff. Oh, because somehow it's more private or something. Okay. I, I, I look at all this and you say,
Starting point is 00:32:34 okay, you've had Dr. David Sinclair on the show. He's, he's been on my show. I write about his research in the book and there are dozens of other people that you and I both know who have spent decades working on aging on different facets on each of these seven pillars and they're saying our work has borne fruit so my supposition is really straightforward if we know that the oldest
Starting point is 00:32:56 person alive today is 120 22 yep give or take madame clement there you go although she might have filled in for her mom there's there's a new accusation about that oh you think she was a con as a matter of fact do you know the single biggest predictor of whether an area is a blue zone or not uh lack of birth certificates yes it's poor economy lack of education and lack of birth certificates i'm not joking very strong statistical correlation so there are a few people who are only half as old as they say they are probably 20 years younger because you know their their mom had them and you know uh so that's not to say there isn't fraud there but if you look back through recorded history i have a book i sit on my bedside table from the grandson of the
Starting point is 00:33:39 caretaker of an indian guy who was said to be5. And there's all kinds of crazy stuff in this book. I don't know if this is real. The guy died, whatever, 1930s. But you look back through all of the different historical texts, things like traditional Chinese medicine, Ayurveda, there is talk and there is research about long-lived people, exceptionally long-lived. I mean, at the turn of the century,
Starting point is 00:34:04 the longest-lived people on the planet were the Plains Indians. They had the most centenarians of any population. Interesting. I didn't know that. Well, they ate, it was buffalo, and a few berries and whatever else they could scrub. Grass-fed buffalo hump, my favorite.
Starting point is 00:34:22 In fact, it's true. With buffalo, the most precious part was the fatty hump on the back and that would go that in the liver it would go to the chief and the kids yeah yeah and it's the same way with the ancient Mayans the ruling class would have fish run in 200 miles from the coast so they could eat fish and they give corn to the slaves right and it's still that you have to run pretty fast so the fish wouldn't rot i think they had like multiple handoffs and it might have been pony express for fish yeah pretty much yeah the fish express
Starting point is 00:34:55 the sardine express and plus their runners were fast i think but it's it it's it's just fascinating to me that if we can't do 50 better than our best today in the next 100 years, given the amazing technology and the research of people that you and I know, it's because an asteroid hit the planet, and then my 180 number might not be any good. So what are those strategies? What are those things that add more years to life? Here's the biggest one. Life to years.
Starting point is 00:35:18 If you were to, one day a week, simply not eat, it would change your life in the most dramatic way. The data behind fasting is so strong, but most people listening have the same mindset I did when I weighed 300 pounds. It's like this. If I don't eat six times a day, my body will go into starvation mode and then I'll gain weight. And also I'll want to kill people because I can't stand not eating for that amount of time. I feel like I'm going to die. And when you build metabolic flexibility, when you use the tips that are in here in superhuman, it turns out you can modulate a hormone called CCK and another one called ghrelin. CCK is the hormone that makes you feel full and ghrelin is the one that makes you feel hungry. And if you've been on a low fat, low calorie or vegan diet, your hunger levels will still be set
Starting point is 00:36:09 to the highest weight, body weight that you've recently had. So if you went from 300 pounds to 250 pounds, you will have the chronic hunger of a 300 pound person and you will lose, the hunger will win. And that's why I actually lost way more than a hundred pounds because you lose 20, gain 30, lose 30, gain 40, lose 40, gain 50. And you yo-yo, everyone who's been fat knows what i'm talking about you have like fat pants in your closet i don't own fat pants anymore they're gone like i don't have to worry about that anymore but it took a long time and a lot of research to get there so what
Starting point is 00:36:38 you're saying you can fix that you can fix that and now you're whatever you are you're not you're not hungry like a 300 pound person no you can reset your fat hunger point and the way you do that is you get ketones present and you could do this by not eating you could do this by putting brain octane in your bulletproof coffee yeah that's what always troubles me you know when the obesity experts talk about the body's set point i mean nobody's set point was 400 pounds i mean historically it doesn't make sense to me your set point is changed based on your metabolism and what you've eaten and your weight, and it can be unchanged. And this crazy thing that we don't talk about this more, all it takes is a blood level in ketones of 0.38. And if you're not a keto dieter person, that's, it's not going to
Starting point is 00:37:23 mean anything. That's for one of the hormones for the other one, 0.48. These are mild levels of ketosis. You know, you do that. Don't eat after the sun goes down, don't have breakfast and have a late lunch. And if you do that, you'll probably bump up. If you have a healthy metabolism, if you don't, you drink a Bulletproof coffee in the morning with brain octane, it'll probably bump your ketones up enough. And all of a sudden this deep level relaxation happens in your body because now you're not craving food like a fat person you've reset and these these studies are out there where the levels of ketones are there so break fast is what you do after you wake up in the morning no just skip that i'm like had dinner it's finished by six something and i didn't eat
Starting point is 00:38:02 till like 10 30 the next morning and i felt great and it was like a you know 14 hour whatever 16 hour fast 14 to 16 hours 18 hours is better and it's just it's something that that i think because of the great depression because there have been times where your grandparents probably starved yeah no matter if you're from europe or the u.s different different causes for that so we just like, how could we go a day without eating? Here's the deal, you'll live a lot longer and be a lot healthier if you do that. And it's fascinating.
Starting point is 00:38:31 But all these techniques, whether it's ketogenic diets, whether it's time-restricted eating, or low-calorie eating for a week, or the fasting-mimicking diet, or just an actual fast for a day a week, all activate the same thing. They all reduce inflammation they increase your antioxidant enzymes they increase your stem cells they increase your mitochondrial repair and
Starting point is 00:38:51 cleaning up your mitochondrial function they increase your bone density increase your muscle mass improve your cognitive function i mean it's it's like a miracle the returns are so high and you'll see in your muffin top the next day you look down like wow like my i have different curves than i used to or maybe i don't have a curve i didn't want one but you see it very dramatically and you feel a new zest for life when you do this and the first time you do it you'll probably feel like crap which is why the stuff i write about here's how to not feel crappy the first time you do it but if you do this every now and then even, you build what I'm calling metabolic flexibility. And in my case, I was at high risk for stroke and heart attack before I was 30.
Starting point is 00:39:32 I was pre-diabetic. I had arthritis in my knee since I was 14. So I had all these fun diseases of aging. Yeah, we should try to get up a picture on the podcast of Dave when he was before. I have fat pictures. My favorite fat picture is from Entrepreneur Magazine. I'm like 280 pounds, and I'm this 23-year-old, the first guy to sell anything over the internet
Starting point is 00:39:49 before anyone knew what the internet was. And I think I have pimples. You were selling t-shirts. Yeah, that's my proof of fat picture. But there's so much that happens around the psychology and emotion of this. But all you have to do is do it once and the next day go wow that was a little hard and i i feel better but if you do it the right way the first day it turns out the amount of caffeine in two small cups of coffee will double
Starting point is 00:40:19 your ketone production you know adding brain octane to your bulletproof coffee or to whatever heck you're having will increase your ketones. So if you can just get your levels up enough, normally it's four days of fasting in order to do that, or you have to eat the bacon only zero carbs diet. But these are just things to reduce your suffering as you learn to do this. But where my metabolism is now, Mark, I am perfectly insulin sensitive. There's a scale that goes from one to 160. I scored one and my glucose tolerance is high. In other words, I can eat sugar better than most people. I just don't. And I can metabolize fat as well as anyone else. And I do
Starting point is 00:40:56 that mostly. And because I move in and out of ketosis, I've built flexibility. So some of the other things that are going to make you live longer it turns out running marathons isn't going to make it yeah no not on my list but regular exercises and we've been completely deceived you know the 10 000 steps a day metric you know where that came from uh no actually uh and it turns out in the late 1950s a japanese company and actually named them in the book they came up with the first pedometer you put on your belt a little mechanical thing that would click every time you took a step and they just decided 10 000 was a good number and so they popularized it and to this day we make trackers like i was cto of a wrist tracking right and the data there there's no data for that it turns out that you need to move for 20 minutes
Starting point is 00:41:47 a day just walk right and you could do yoga you could do a whole bite of vibration and you can do all sorts of whatever's but just moving around for 20 minutes a day and then once or maybe twice a week lift something really heavy or do something that makes you pretty much want to throw up like really fast sprint and then stop but do it twice That's all it is just to raise your heart rate and get it back down quickly. Those two things are going to create the stimulus you need because one of the things that hits us as we age, those throw up training is what you want to do. Pretty,
Starting point is 00:42:16 pretty much. They call it high intensity interval training, but look, lifting something really heavy until you can't lift it. It sucks. And when you're done, you're, yeah,
Starting point is 00:42:23 I can't, I don't think, I don't know how people like that. No, going for a bike ride but like i started weight training recently i'm like i need this big guy kind of encouraging me because otherwise i wouldn't do it on my own yeah like i kind of wimp out i'm like all right i did three it's fine no he's like do 12 i'm like okay and it's that pushing yourself to the limit yeah that makes the difference and yeah get help doing that but we're talking 15 minutes of pain once a week yeah and compared to an hour of going to the spin class every day that actually isn't going to help you age less in fact you might wear out your hips that way
Starting point is 00:42:53 yeah so you save time and you got more anti-aging benefits and if you go for a walk with a loved one well did you actually get that time back anyway? You did. So now you're exercising more intelligently. And speaking of this occasionally lifting something heavy, one of the other seven pillars of aging is actually just tissue loss. It turns out as we age- Muscle loss. Yeah, muscle loss, but also skin. In the book, I talk about collagen very specifically. Bulletproof is one of the reasons everyone's putting collagen protein in everything because I started writing about it and talking about it about a decade ago.
Starting point is 00:43:29 And it's, oh, this actually matters. Your skin is made of collagen. Collagen is the fascia that holds your muscles. It's the matrix for your bones. It's terribly important. But your ability to make collagen goes down over time. That's why you have thin skin as you age. It turns out there's things you can do that increase thickness of your collagen.
Starting point is 00:43:50 In fact, can you help me with my wrinkles? I'm going to help you with your wrinkles, but not just wrinkles. We're talking about the thickness of your skin, which is really important because along with muscle wasting, sarcopenia, which is a problem for older people,
Starting point is 00:44:03 you also get just thinning of all tissues in the body i remember my mother's skin used to just fall off like she would touch herself and like it would rip it would tear yeah yeah well you can change the rate of collagen deposition by using light therapy by getting some sunlight but not too much by eating more collagen and by doing less things that prevent the breakdown of collagen. Like? Like, or you could make sure you have enough vitamin C, don't eat bad fats. The usual. The usual.
Starting point is 00:44:30 It turns out so many of the basic habits we're talking about support the reversal of aging. But then it comes down to something like stem cell exhaustion, which is part of this tissue thing. So you reduce the loss of tissues, you increase the turnover rate of tissues and then you say well what do i do about stem cells because you run out of stem cells as you age so in superhuman i talk about how i've done um probably the most extensive stem cell
Starting point is 00:44:57 treatment done on one person at one time where i had three doctors working on me for four hours the total body makeover yeah the stem cell total body makeover with Dr. Harry Adelson. And this isn't something most of us are ever going to do. Frankly, it was kind of painful. However, I'm looking to live to 180, and I would like, you know, I'm almost 50, and I'd like my body to remain youthful and to have those reserves of stem cells and to go through and fix old injuries so that's what i did and i talk about that but i also talk about things you can do
Starting point is 00:45:32 to make sure that you have adequate stem cell reserves and it turns out mark it's the same stuff right maybe sometimes you should try some intermittent fasting maybe you shouldn't eat bad fats maybe you should exercise don't eat. Maybe you shouldn't eat bad fats. Maybe you should exercise. Don't eat grains. And those things are shown in studies to improve stem cells. But one of the things, we haven't hit on too much, but you talked about in the introduction, is sleep. Yeah.
Starting point is 00:45:55 And if you want more stem cells and more growth hormone, all the good stuff, you've got to sleep. So I was looking at my sleep score for last night. You have the Oura ring? I have the Oura ring. Okay. Do have the aura ring? I have the aura ring. Okay. Do you have one too? I got one too.
Starting point is 00:46:07 So I've been an advisor to the company for a while because I was CTO of another risk tracking company called Basis Wildback. So I really know this space well. The ring is ridiculous. But I looked at my sleep score last night. I slept, let's see, six hours and 50 minutes. But I got two hours and 50 minutes of REM
Starting point is 00:46:24 and an hour and 19 minutes of deep sleep in a hotel when I landed at night. Impressive. So this is more- Impressive. This is more- Let's see, what was mine? Oh yeah.
Starting point is 00:46:33 Oh, let's compare sleep. Mine. Okay. So mine, oh wait, that's Uber. I don't want the Uber app. Wait. As you're looking it up,
Starting point is 00:46:42 it turns out as you age, your amount of deep sleep and REM sleep goes down predictably unless you do something about it so I'm getting more sleep than a 20 year old I got a I was in bed for eight and a half hours I slept seven hours and 15 minutes I had a 91 sleep score nice my total sleep was 750 minutes but an hour and a half of rem uh deep sleep was 54 latency was 13 minutes which means not telling to make it to sleep but i had restfulness i was tossing around because i was i was you know i'm traveling so i'm in california i'm staying in a friend's house i'm in their bed right i'm going to bed late like i'm on the east coast like 10 o'clock so yeah i mean it wasn't as
Starting point is 00:47:20 good as i'd like but it's still yesterday it's still yesterday. I got 92 and I had all, I had all, um, uh, blues, which is no bad thing. So, but it's not always like that. Like, you know, it's not, but if you do what it takes to sleep better and I talk about sleep in the book, it's been a big theme for me because frankly, I was really bad at sleeping and I never wanted to sleep because it seemed like such a waste of time. Yeah. And now look, if you sleep six and a half hours a night, well, you're in the group of people who lives the longest six and a half,
Starting point is 00:47:52 believe it or not. The most granular study ever done. I want to point to more than that. It's okay. It's just that people who need more than six and a half hours of sleep die more often than people who need six and a half hours of sleep. Now you're making me feel really bad. I'm gonna make it to 180 here's here's the eight hours here's why that works um people who are healthier need less sleep yeah right or people
Starting point is 00:48:13 who sleep better need less sleep yeah so i am very well rested in my six and a half hours of sleep and sometimes less but i learned to change things that make me sleep like i'm 20 instead of like so let's just touch on that for a minute we've had some shows on sleep but you know we talked about food we talked about the right kind of exercise we talked about intermittent fasting we talked about you know the sleep issue that the problem in this country is that most americans don't sleep well you know it's an epidemic of poor sleep we've reduced our number of hours of sleep over the last 100 years dramatically we have screens at night we have you're wearing the blue blocker glasses right now it's one of the companies i started called true dark yeah and it it matters
Starting point is 00:48:53 the light thing and eating too late are the two biggest things for sleep yeah so i i think you know getting healthy sleep is important and it's stress response. So things like meditation really help ramp you down. Not drinking too much coffee or not having it late. After 2 p.m., don't drink coffee unless it's decaf. Don't exercise after dinner. Don't eat late. No three hours before bed. Blue blocker glasses.
Starting point is 00:49:16 Get off screens. I mean, these techniques really work. They work in a way that's measurable. And throughout history, you could just wake up and say, do I feel like I slept well? And then you could turn to your spouse and say, did I wake you up with snoring? But my phone tells me it records if I snore. And I don't snore very much anymore because if you eat foods that make you inflamed, you
Starting point is 00:49:35 snore a lot. If you eat the right foods, you don't snore. And if you keep snoring, then you get it fixed. And when you go through all this stuff, you realize, wait a minute, I didn't have to spend any more to learn how to sleep well. And it was cheaper to do that than it was to go on growth hormone and all of these other things. So sleep is one of the cheapest and most effective ways to literally age backwards by causing
Starting point is 00:49:57 yourselves to self-repair in a way they wouldn't do if you got exactly the same amount of sleep, but it was bad sleep. So I talk about here's what different kinds of sleep do for you and here's how to get them. And for me, the True Dark, the patented glasses for sleep that are more than blue blockers, they doubled my deep sleep. And when I use a specific kind of mushroom extract before bed, I tripled my REM sleep.
Starting point is 00:50:22 That's why my scores were that high. I found out what worked. What kind of mushroom extract? Do tell, Dr. Dave? It's an Australian species of lion's mane mushroom. It's a company called Life Cycle makes it. And the guys came on my show and talked about it. And lion's mane is shown in studies to do stuff, but I never felt normal lion's mane when I took it. There was no difference this stuff because of the way it's extracted i think because of the australian species my score goes up every single time i take it so i i don't travel without it i always take it okay life cycle lion's mane true dark twilight glasses and you can lower the temperature do the glasses all the time because you wear them during the day do. So TrueDark makes the ones for jet lag and heavy duty sleep. And I'll wear those for at least a half hour before bed.
Starting point is 00:51:09 So when I was flying to LA last night, I was on a flight around seven o'clock. So I put on the glasses that help your brain know that it's nighttime. So I'm wearing tinted glasses that are in the red spectrum, not just blue blockers. Blue blockers don't do enough for sleep. They help, but they're not enough. And I do that that and i feel great the ones i'm wearing right now these are the daytime glasses that block 75 of blue light so we've got bright studio lights i'm on camera for about 12 hours today and if i stare at bright lights especially led lights i actually get tired after a while your brain gets worn out i wear these my eyes are happy my brain is happy all day long let me try those you sent me some i have them in my house oh yeah it it actually is more my your brain relax it's yes it's interesting it's like the light's kind of hurting my brain and now
Starting point is 00:51:58 yeah it's an unconscious thing light creates pressure i feel like i got relief like like someone was stepping on my foot and got off but you wouldn't notice it if they slowly put pressure on your foot right we're in for another couple minutes and just watch what your brain does that's fascinating so here's what's going on people listening to this you stare at your screen and you haven't turned it down at least halfway during the day you start a bright screen on your computer all day long you're underneath bright led lights and at the end of the day you you say, wow, I don't know what's wrong, but I really want a cookie. And I'm so tired.
Starting point is 00:52:29 Okay, so let's recap here, because this is really important. One, which glasses should you wear when and for how long, and where do you get them? Because you talked about two different kinds of glasses. Got it. So TrueDark is the company,
Starting point is 00:52:41 TrueDark.com, and just full disclosure, I started the company, I wrote patents for this company because true dark.com and just full disclosure. I started the company. I wrote patents for this company because of the light science and eyes. I'm really into this. It's an important biohack. And at true dark, there's something called sunset or twilight.
Starting point is 00:52:55 Those are the ones you wear before bed. Those are things that happen at night. And then the day walkers are what you're wearing. Oh, the, and the sunset one is the one that you can nighttime, nighttime when jet lag and traveling okay so you do sunsets for nighttime and day walkers for the day and you don't have
Starting point is 00:53:11 to wear them all the time we make ones that are less yellow than the ones you're wearing but the bottom line is if you want to be awake alert and feel like yourself at the end of a day of sitting in bright lights if you wear glasses you will feel so different. Oh, I'm so down, this is great. Okay, well, you're not getting these back, but. I already sent you a pair. I know, I got them in my drawer at home. All right, so let's go through again, talking about the different strategies for living to 180,
Starting point is 00:53:38 and sleep is key, blue, blacker glasses, all the strategies we just talked about. What else? You know, the other thing that is in the book is having connections, having relationships. And it all comes back to those dumb little mitochondria we talked about before. If you're a life form, it doesn't matter if you're a cactus or an amoeba or a human,
Starting point is 00:54:04 you run the same order of operations. The first thing is run away from kill or hide from scary things because if something kills you right now, it's the end of life. Okay. So that's why we spend so much of our time in anxiety and stress because our automated systems are looking for something that might be bad for you. Yeah.
Starting point is 00:54:20 Okay. And this is that we overweight, we over-remember the negative things. We don't remember the positive things. The second thing we do, we eat everything. and that's why you keep eating junk food you didn't mean to eat because your cells are making you do it the third thing we do is so we have let's see we had fear we had food the other one's also an f word that involves reproduction okay because all life forms have to reproduce right okay so if we spend most of our energy doing those things those are all the things pretty much everything we've ever been ashamed of has
Starting point is 00:54:50 come from one of those categories right but is there something else that life does it's another effort called friend right so we are wired in order to do those things and if you community connection community connection have friends special specialize in something and support the people around you. And it's why we have biofilms on medical implants. It's why yogurt works. It's why you can have kombucha. And so we're wired at a very deep level to have a strong community.
Starting point is 00:55:17 And if you want to live a very long time, you look at those four things and you make sure you don't have too much stress and you don't feel afraid all the time. And sometimes you have to go to a therapist like you got to do your personal work on that one that's one of the key aspects of the blue zones yeah yeah poverty and fraud and birth certificates no the community community i mean i'm so teasing i mean the whole idea like in japan and okinawa they have the mo Moais, which is the parents put together a group
Starting point is 00:55:45 of four or five kids from birth. And then they become their community. And they go through every stage of life with them. Isn't that just beautiful? It's powerful. I mean, I just had lunch with a friend of mine this last weekend. We've been friends for 40 years. And we've been through ups and downs, divorces deaths and it's just you know very powerful
Starting point is 00:56:06 feeling to be that seen known loved connected and we have a culture of loneliness we have a culture of isolation we have a culture where we're so separate for each other despite you know having 5 000 friends on facebook we might not have one friend we can call it it happens on a on a regular basis you want to live a long time well the cure for that is actually having friends of different ages and this goes for everyone listening if you are 70 and you're looking around going some of my friends can't go for walks anymore some of of my friends are dying. You better get yourself some younger friends. Yeah. It's time. Most of my friends are my biological age. And if you're young, the way you stay young and the way you get ahead is instead of making all the mistakes yourself,
Starting point is 00:57:00 ask someone who's already made the mistakes, how to not make them. So your job is to go out and find someone three times your age. That's how I did what I did. Mark, I was 26 years old. I was fat and tired. My brain wasn't working. And I felt like crap. And I found people who were 80 who had fixed it themselves. And they took me under the wing and taught me this stuff. That's what I'm sharing right now. So you need to find people who are old, the kind of people that you probably frankly don't see right now, because when people hit a certain age, my parents have told me this. I remember the first time I became invisible. People just didn't look at me. And this is not okay. This is not how you treat the wise
Starting point is 00:57:41 elders of our generation. So get an older friend if you're young, get a younger friend if you're old. And that's one of the simplest things you can do to live longer for both people. What if people are just generally isolated? What do you suggest for them to how to build connections and find friends? You know, it's really such a personal thing, but if you're isolated, it's probably something you're doing and it's probably fear-based. Remember those mitochondria? Things that might be scary. If you were hurt sometime, you were bullied in seventh grade, someone abandoned you when you were young, you will still be at an unconscious level
Starting point is 00:58:13 looking for that in your cells. And so until you do that deep work and just feeling safe and being connected to people, you'll probably create that. So a lot of this work is around improve your psychology, improve your emotions yeah but here's the trick if you want to do that work and your mitochondria can't make enough energy you're not going to be able to there's a study now about willpower that proves it willpower comes from
Starting point is 00:58:37 electrons that comes from mitochondria so if you want to improve your situation where you have friends and community deep connections with people who care about you well if you're too tired to get out of bed in the morning you will not do it so you fix your biology and then you fix your friends that's great okay now there's two other big things you talk about in the book which are kind of novel a little different and i have intimate experience with both of them unfortunately which are toxins and ozone yes so let's talk about what you learned about the role of environmental toxins and heavy metals particularly in aging and tell us why it's important and what we should do about it these are really big topics when you look at what happens when any animal gets older they accumulate certain things from the environment over time. And I like to go
Starting point is 00:59:25 fishing in Alaska with friends. And if I catch a hundred pound halibut, I'm throwing it back because that's a hundred year old fish full of mercury and nickel and lead and cadmium. And if you catch a young one, then it actually has far less toxins. So kids have less toxins, but they're more susceptible to toxins and if you look at what happens as we age mercury lead cadmium thallium if you a lot of kale isn't is an emerging big problem from california any kale is full of thallium it's uh it's the the world nature's strongest uh attractant of that detoxifier yeah so and alsoic. Arsenic is another big one. Thank you. So if you're going to live to 180, you are going to be full of metals. Metals inhibit mitochondrial function.
Starting point is 01:00:11 They lower your testosterone. They cause hair loss. They cause graying and they cause cancer as well as actually a whole bunch of other diseases. So you've got to lower your exposure to them and you have to get rid of them as you live. And there's compounds I write about called chelating agents that you can take with your food. When I eat sushi, you need the fat from fish. I take chlorella, which is a fracture of so well, chlorella will bind to the mercury in the gut. So you poop it out, but chlorella will not pull mercury out of your brain. So what you end up doing is over time, you lower the incidence of metal entering your body and you slowly remove what's in your body.
Starting point is 01:00:49 And I talk about how to do that in the book, but if you don't know that metals matter and you're just gonna eat the surface, you have a problem. So can you measure how much metals you have in your system? Yeah, there's two ways in superhuman that I write about. The gold standard is you collect urine and see what your body's excreting
Starting point is 01:01:05 with or without an agent that may cause you to release more. And then a more common and cheaper way, but less telling is a hair test. And there's usefulness for both of those, but you can go to a functional medicine doctor and say, I'd like to do a heavy metals test. And they'll usually order a urine test for you.
Starting point is 01:01:21 And it's very common to find elevated mercury and lead. In fact, if you're over 40 you're probably going to find it yeah so here let me just share with you as a practicing physician who one suffered from mercury poisoning added two and two have treated literally tens of thousands of people with metal poisoning and have done tens of thousands of tests and i would say it's probably one of the most ignored yeah um and underappreciated causes of chronic disease that doctors don't know how to think about well test or measure and personally for me i lived in china and it got huge exposure to mercury i don't have great genes of detoxifying and it destroyed every system in my body yes destroyed my gut i had diarrhea for years and bloating and pain it destroyed my mitochondria
Starting point is 01:02:15 i developed chronic fatigue syndrome and it was such an extreme version that my muscle enzymes were high my cpks were like 600 my liver was affected my immune system was affected i started developing rashes and sores all over i was completely cognitively impaired i couldn't focus think concentrate remember where i was you know in you're not in thought yeah this was like you know 25 years ago and i was so bad and i literally had to become an expert in mercury and heavy metals and detoxification and i've written a lot about it but i think you know i would say that for many of my patients who suffer from weird or strange ailments it's right at the top of my list of things to look at and the only way to really
Starting point is 01:02:55 know what your body burden is you can look at your blood but that only checks 90 days yeah i mean if you're eating a lot of sushi you'll see it's's high, but 90 days you stop, it'll go away. You can look at your urine, but your urine also isn't going to be high unless there's a current exposure. So if you're in a lead foundry or you're eating tons of sushi, you might see a little bit of mercury. The only way to really look at your body burden is to do a challenge test where you take a pill, it's a chelator, and you collect your urine for six hours. Hair tests also check for fish methylmercury
Starting point is 01:03:25 which is where we mostly get our our mercury from but that that also will go away if you haven't eaten fish for a while and then there's another test that looks at the blood work that measures the inorganic mercury which comes from pollution or from fillings and that's called the quicksilver test and that that is surprisingly high in people who have a mouthful of fillings and that's called the quicksilver test and that that is surprisingly high in people who have a mouthful of fillings and you can see the difference between fish or or or a dental mercury and the treatments are depending on the person you know can be very aggressive depending on what they need to kind of i have a patient who's got this terrible autoimmune disease and we're giving her intravenous support
Starting point is 01:04:05 other people can use oral support there's medications and but it's it's a it's a whole process that has to be done safely it's i think your point is really well taken i think it's an underserved an underappreciated component of medicine and hopefully one day we'll get on board with this because it's just i mean it, it was interesting. There was an article in the New York Times that I was quoted in. It was based on these special forces. Oh, yeah. Those guys get led, right? Yeah.
Starting point is 01:04:31 So this guy came to see me whose job was he was a special forces guy who was a blast expert. So they would go blow up stuff, blow up doors, blow up this. And they had to train and practice. And they had indoor practice training. and these guys were getting all sick and now you know the special forces guys aren't malingerers they're not whiners they're not like oh i don't feel good i don't want to work those aren't those guys these are the guys who you know like stay in freezing ice water for an hour and swim you know right right and do 4 000 push-ups and like you know yeah don't sleep for three days i mean these guys are not whiners they're super humans right yeah and so the guy came in i'm like okay well tell me about your job like oh we blow stuff up we shoot thing i'm like
Starting point is 01:05:13 oh okay and so i said let's check your heavy metals and they were sky high we put him through a whole program he was you know metabolically his system wasn't working he was overweight he had pre-diabetes He had cognitive dysfunction. He had all these immune issues, gut issues. All got better. And then he started sending all these special forces guys to us. And we started treating them. And they just all got better. And one of them was written about in the New York Times.
Starting point is 01:05:36 Wow. Because his, you know, medical crew and everybody dismissed him. And he completely turned around. And the guy who was the lead expert at Mount Sinai, who measures bone lead, which is the most accurate way to measure lead in the body. It's not an easy available commercial test, but it's a very powerful research tool.
Starting point is 01:05:55 He said, these guys had really high levels of lead. And he said, on the follow-up test, he saw the levels come way down. And he says, he's never seen that in his entire experience. And this is a guy who's an expert in lead. How can you be an expert in lead and not know how to poison the body? It drives me nuts. Because it's not seen as a problem.
Starting point is 01:06:14 Acute poisoning, yes. Chronic poisoning, no. And there's nothing you can, quote, do about it. It's just nonsense. And there's, in fact, an FDA-approved drug called DMSA. It's designed for lead removal and actually removes mercury. So I think, you know, for people listening, if you have any strange or weird ailments, if you have anxiety, depression, insomnia, autoimmune disease, gut issues, fatigue,
Starting point is 01:06:34 cognitive issues, it may well be heavy metals. And you need to find a good functional medicine doctor to help you diagnose that. And you go to functionalmedicine.org or ifm.org and you can find a practitioner who may know how to do this. I'm going to go a little bit broader than that. If you are over 50 and you have not gone through a course of chelation, you are not doing aging right. You have to do this if you are alive in the modern world
Starting point is 01:06:59 and you want to live to a highly functional old age. And the reason I say this is that the safe epa limits for lead used to be 20 parts per million and they cut it was 40 it was 40 to 20 to 10 to 5 to 5 and now they're finding even down to one they're seeing cognitive impairment in kids cognitive impairment and increased risk of cardiovascular disease And now the people who are the experts in lead are saying, quote, there is no safe limit of lead. And if you are 40 or 50, you cannot be alive and not have a lead burden in your body. You must remove it.
Starting point is 01:07:33 And it's not that hard, especially if you're not really sick. It's not going to be a big deal. And it's so strange, Dave, because medicine just ignores this. But in the journal Circulation, which is one of the top cardiology journals, there was a paper a number of years ago that showed that if your lead level was over two, which is quote within the normal limits, which by the way affects almost 40% of the population, has this lead level, that your risk of stroke goes up 89%. The risk of a heart attack goes up 150%.
Starting point is 01:08:02 The risk of death goes up from a heart attack 55%. And this is more than smoking or cholesterol. And it's like, well, why doesn't your cardiologist talk to you about this? Well, you remember those four killers we talked about at the beginning of the interview? All of those are tied to metals in the body. Yes. And especially Alzheimer's. Diabetes can be like arsenic, Alzheimer's.
Starting point is 01:08:25 It's nuts. And so this is one of those things where if you want to feel good, you do this on a regular basis. So what are the basic tips, if you're not going to get chelated, what are the basic tips for detoxifying? For detoxifying not just metals, or you mean metals? Metals. Like how do you, I mean, it all works for everything, but how do you-
Starting point is 01:08:43 One of my favorite compounds is glutathione. And you can increase glutathione levels by increasing vitamin C, by taking N-acetylcysteine. I manufacture a glutathione pill. You can get intravenous glutathione. Lipoic acid. And you do IV glutathione at your clinics, right? Yeah.
Starting point is 01:08:59 Yeah, and we do it at Upgrade Labs in LA for people to recover better. Alpha lipoic acid is another thing. Selenium can help. And zinc can help. The natural chelator. Cilantro. But surprisingly, you want to take cilantro only after you've removed most of the metal from your body
Starting point is 01:09:16 because cilantro can actually move heavy metals into the brain because it's one of the things that can also penetrate the blood barrier. So you go through and you say, I'm just gonna build some of these in on a regular basis. And then you need fiber. You need to poop and pee and sweat. Shocking how those work. One of the things I write about in here.
Starting point is 01:09:34 Triple P therapy, I call it. Whoop, pee and perspire. So there's something called modified citrus pectin, where they take the white rind of oranges and lemons and they modify it with an enzyme that is shown to really nicely bind to all these heavy metals. The problem though, if you start taking large doses of that when you're young, it can actually do bad things to you. So this is something that you might take occasionally when you're young and you might
Starting point is 01:10:02 take it more often as you age. And in superhuman, there's other stuff Mark that people would never know about. And probably something that's really interesting. I interviewed Dr. Andrew, a new house from Vanderbilt university wrote the first study on nicotine as a way to cure Alzheimer's disease, not smoking,
Starting point is 01:10:23 smoking and using tobacco are bad for you, but using oral nicotine, a spray or a gum or a lozenge or a patch. And there is an argument that I make in superhuman that says, as, as you age, you might want to use one or two milligrams. We're talking like 5% of what's in a cigarette, small amounts of nicotine in order to enhance cognitive function and reduce your risk of Alzheimer's. And a lot of vaping and smoking, this is not an argument to do that, but it's to say small amounts of those will improve cognitive function. They feel good, and they are probably anti-aging compounds
Starting point is 01:10:59 as long as you don't overdo it. So I talk about how would you use that, how would you do that? And it's not an excuse to smoke. It's not to vape it's just look at that little spray thing you get yeah i was just trying to spray it under my tongue and get me high every time you do it you feel great i'm just worried about alzheimer's mark i mean you're 60 now yeah i'm not worried about you oh my god okay all right now yeah metals are a real deal and learning how to detoxify learning how to up regular mitochondria and fix them learning how to cool off inflammation these are the central strategies around healthy aging and then there's other things there's um this whole
Starting point is 01:11:37 technology that you talk about called ozone which sounds like. We're worried about the ozone layer and aerosol cans. And what do you mean ozone? Ozone is something that most of us know of as a pollutant. It turns out though, that it is a free radical. And as long as you don't breathe ozone, ozone is profoundly good for your cells because your mitochondria, they look for free radicals and we all say, oh, free radicals, oxidants, these are bad for you. Like this is a problem, but it turns out if you don't have any free radicals, your mitochondria become lazy and weak. So you can use ozone. You can use it intravenously. You can use it rectally. You can sit in a bag with ozone therapy anywhere from the neck down,
Starting point is 01:12:21 as long as you don't breathe it and you can use it vaginally even and it has profound anti-aging effects it will wake up bad mitochondria it will get rid of old mitochondria it is broad spectrum antimicrobial it'll fix infections i've interviewed people who use it's the most powerful disinfectant on the planet like you use it in world war one tesla invented the machine not uh not uh not the car not the car but you know nikolai tesla invented the ozone generator yeah it's a little spark gap thing i have one at home you have one in your office i do and you're saying well wait how could this be well it turns out dr robert rowan cured ebola during the last outbreak in africa with ozone they've
Starting point is 01:13:03 been using on drug resistant tuberculosis they've been using it on drug-resistant tuberculosis. They've been using it on cancer, especially in Cuba and Russia, places where they couldn't afford pharmaceutical drugs. So there's hundreds of papers and studies and more than 100 years of use of this stuff. But most people have never heard of it. I will simply say, if you want to live a very long time,
Starting point is 01:13:21 one thing that is going to happen is you will accumulate the weird infections of old age and these are bacteria that take 20 30 40 years to start having an impact on you mycoplasma cell wall deficient things and they come from mosquitoes they come from ticks they come from making out with people the older you are the more likely you are to have done that they come from your teeth from your. The gingivalis, which is a dental bacteria, has been shown now linked to Alzheimer's in the brain. The Alzheimer's and also just a cardiovascular disease, right? Yeah.
Starting point is 01:13:52 So what if when you had a root canal, they used ozone to sterilize it? That's what I tell you to do in the book. What if on an occasional basis you did some routine ozone therapy because it lowers the bacterial load in your body and it wakes up your cells yeah it changed my whole life when i weighed 300 pounds i'd been exposed to toxic mold which is another massive you and me both people oh yeah i mean we're we're mold brothers and uh i was in i was in your movie moldy you were that's right uh moldy movie.com it's still available for free screening but and the irony of that is when i
Starting point is 01:14:25 recorded that movie i was actually living in my house which i didn't know at the time was full of mold yes and very shortly thereafter i became deathly ill from mold i was worried about you it really mold it takes away your energy first it's a lot like being old actually cognitive function energy your immune system i mean it just like yeah and wreck you i grew up in a basement that had toxic mold so a lot of the reasons that i know about the aging things not the not just the 20 years of running an anti-aging non-profit it's also because i felt all of those things in my 20s that you don't want to go back to that so ozone you said it saved your life from the mold.
Starting point is 01:15:05 It really did. And I bought an ozone machine. And I write about the story in Superhuman. And I used ozone every single night when I was home for a year and a half. And it restored my brain function. It turned my mitochondria back on. And to this day, I would credit that with having a huge difference. So people who are old or who are getting old or who are just tired and feeling old,
Starting point is 01:15:27 this is one of those things. It's cheap. You can do it at home, but you need to learn how to do it at a medical practitioner's. Yeah, rectal ozone. And it's pretty darn safe and remarkably effective. Yeah, it's pretty interesting.
Starting point is 01:15:40 I mean, I was so ill from the mold and I had a whole series of things I've talked about before, but essentially I lived in a house with mold mold i developed a horrible cough for a year i had a root canal that went bad and got it taken out took an antibiotic which was called clindamycin that then caused something called c diff which is a terrible intestinal infection then i broke my arms i had all this perfect storm of injuries and I literally was knocked to my knees so I developed colitis from the c-diff I developed gastritis my stomach my whole
Starting point is 01:16:13 intestinal lining from my stomach down all the way to my butt was just one big raw mess I lost 30 pounds I couldn't think I couldn't focus I couldn't answer an email I could be on a phone call your your eyes lost their sparkle I mean I I saw you i'm like oh my god i'm really worried about you like you could tell it yeah it was it was it's true i was i was ready to go like i was on my way out yeah and struggled struggled struggled and you know you talked about ozone and a few other people i knew talked about it was and i remembered my patients saying to me you know the thing that really helped me when i was sick and nothing else helped me whether it was an autoimmune disease or tick infections or whatever was ozone i was like i always kind of had it in my mind as one of those
Starting point is 01:16:52 things that yeah it's interesting because i listen to my patients you know when they tell me i tried everything but nothing worked except i pay attention so i'm like i put together a whole strategy and i went found someone who did ozone intravenous ozone and i remember you can ask my wife but literally two days in yeah two days in i was like my brain's back online it's that turning your brain on matters the most force seven pain in my stomach was gone my colitis was gone yeah my energy increased this was in two days and then i you know needed more and i stayed on it and then i did a time something called 10 pass which is really powerful we do that in our center at the ultra wellness center and it's super controversial um it shouldn't be because it works so well it's
Starting point is 01:17:34 being done in most countries other than the u.s on a regular basis and it's a powerful modality because it's an oxidant so we think of antioxidants as being what we should be taking like vitamin C and vitamin E and so forth, but we also need oxidants. So it's a balance. And when you take ozone, it's a massive oxidant, but it only lasts for a few seconds. And then it turns on, it's like a trigger that turns on your body's own antioxidant system. It turns on your immune system to fight things like infections it kills everything that should be killed in your bloodstream it shouldn't be there it improves the function of your mitochondria and it also increases stem cell production yes so it's like
Starting point is 01:18:16 wow why aren't we using this and it's super cheap it's super cheap because it's just like this little machine and yet i mean it's pretty interesting so it's just like this little machine. And yet, I mean, it's pretty interesting. So I think, I think, you know, unfortunately we don't have enough science. We don't have big randomized trials. You know,
Starting point is 01:18:30 we have a lot of data, but we have textbooks on it. It's used a lot in Europe and Cuba and South America and Latin America, but it's, it's, it's, it's this kind of surprising therapy that I think is going to hold a lot of promise for many things that we're suffering from today. I would just say that they can have my ozone machine when they pry it from
Starting point is 01:18:50 my cold dead fingers. I mean, it is that fundamental. And my, my daughter scratched her ear on a rose and got some sort of nasty infection. It was three times the size it should be. This is when you would normally go for antibiotics. My wife's an ER doctor. So we're not afraid of using antibiotics. They're just a last line measure. So let's try this. So we took ozone and we put it in a, inside a funnel, not even a syringe, and just, just held it over her ear. It'll absorb through the skin. Two treatments of 20 minutes and the ear returned to normal. It was completely fixed. Two 20 minute treatments treatments. Well, they used to do that in World War I. They would wrap cloths and soak them in ozone and then they would put them around the wounds
Starting point is 01:19:31 to heal wounds because they didn't have antibiotics back then. And it works. So this is one of those things where, what is it doing in a book about anti-aging? If you do this even once a year, your cells will be healthier for many years and you'll have a lowered risk and i'm
Starting point is 01:19:47 making some suppositions here based on how things work you have a lowered risk of many of the diseases of aging because it makes for healthier mitochondria and you talk a lot about the science and the research and the studies yeah it's real it's real yeah i mean it's it's powerful um you know sort of one of those things like heavy metals it's sort of on the diaspora of medicine it's like and i i only went to these places mark because when i did the normal medical stuff like oh maybe you should eat healthy and exercise that crap didn't work i worked out an hour and a half a day six days a week i went on a low fat low calorie semi-vegetarian diet and i still weighed 300 pounds and now i was muscular and i was covered in fat and i was tired all the time because i was working out too much and no it, it's not what it was. And the antibiotics I got every month for sinus infections
Starting point is 01:20:29 that whole time weren't helping either because the doctor didn't tell me about toxic mold, didn't tell me about toxic metals, didn't tell me about ozone. If someone had told me those three things when I was 16, the amount of time, energy, suffering, and money that went into making me well would have been 5% of what it is. And it works at every age it's pretty amazing this is such a powerful book dave super human the bulletproof plan to age backward and maybe even live forever i'm not sure i want to live forever but you know if i like the option you can check out when you're done mark i already know what you really want you want to die at a time and by a method of your own choosing i want to die young as late as possible there you go
Starting point is 01:21:10 so let's talk about some of these more extreme things because they're kind of interesting and i think they're still not ready for prime time but things like stem cell injections intravenous laser and neurofeedback so what is all that about well stem cell injections are shockingly effective and the fact that there's any regulatory question about them at all is just an economic thing like if they're your own stem if they're your own stem cells and i've seen some nasty stuff from people using like weird stuff well the thing is you don't necessarily know what's in stem cells from someone else. But if you're getting your own stem cells and they pull them out and grow them overnight in a lab, so you have many more of them that are stronger,
Starting point is 01:21:51 and then you choose to put them back in, the logical listener would conclude that this is probably your own tissues and you own them and you can do what you want. In some countries, actually just one country, the US, there's a drug company policy that says once the cells leave your body they magically transform into pharmaceutical substances that are no longer yours just like your poop your poop is regulated by as a drug by the fda that's why i stopped pooping that's why you're full of it. Oh, God. Now everything makes sense. And I don't understand the logic here,
Starting point is 01:22:35 but I've had fantastic benefits from not pooping. I'm sorry, from stem cells. Oh, gosh. You can tell Dave and I are friends. Oh, absolutely. If you can make poop jokes on a podcast, you're friends. And it's like, Mark, I've sent my parents in for stem cells. My own history of three knee surgeries before I was 23,
Starting point is 01:22:58 having arthritis in my knees, and just old injuries and chronic inflammation for many years. I did not start out healthy. So if I can do what I'm doing and be in men's health with my shirt off at 46 years old. Come on, stop bragging. Well, I'm a fat computer hacker by training. These are the most unlikely things ever to happen in my life. You're ripped on the cover of men's health.
Starting point is 01:23:18 All right. We can compare six packs later. It doesn't make sense that if I can do it, that everyone isn't doing it because it's less work for them than it was for me yeah that's like i'm the worst possible guinea pig here and what does stem cells do and why should we be interested in that what they do is they go into your body and they find parts of your body where there's inflammation and they stick to those parts of the body and then they secrete healing factors that cause the tissues there to recover. And I had a family member who was scheduled to go in for heart surgery for a heart valve problem. And I arranged for him to get stem cells,
Starting point is 01:23:56 his own stem cells from fats taken out and just intravenously injected, not for the heart at all, just for general wellness. And he went in four weeks later to the doctor to do a scan before the surgery. And they said, um, the problem's gone. He didn't have to get heart surgery. Um, now I look at, I look at that kind of a result. So that's pretty extreme. but when i look at what happened with the stem cells that i had it's amazing and with my wife lana when she was nine she fell out of a multiple story building playing at a construction site as nine-year-olds will do she's had a frozen neck
Starting point is 01:24:36 she can only turn her head yeah a small amount in one direction three days after dr harry injected her neck she could turn her neck and she said well i've never been able to do this before yeah you know i had the same thing i i don't know why but my neck would always go out i'd have to go to the chiropractor it would get stuck and it was uncomfortable painful and it was just annoying as hell and harry injected my neck and no more pain no more it doesn't go out anymore i never have any discomfort it doesn't feel weird i'm like back to new and you said the keywords back to new and that's why i feel good about saying age backward on the cover of my book because hold on did my wife just go back to nine years old in terms of she got rid of an injury that's been there for 50 years right or maybe 40 years however i'm not good at math but same thing here we all have these things and as you age you accumulate these injuries oh yeah i
Starting point is 01:25:32 limp a little bit whenever i have too much to drink or if i eat gluten or whatever oh yeah my grip is a little bit off just getting a little bit of arthritis over here screw that noise that is not acceptable you need to hold the line and maybe even move the line backwards. I think that's an important point, Dave. Most people don't realize this. Most people don't realize how good they can feel. They just accept the slow degeneration of the human body as a natural phenomena, but it's really an unnatural phenomena. It's not how it's supposed to be. And you should die fully fully functional that's the plan yep die young as late as possible all right now um what about the whole thing about well you know we're going
Starting point is 01:26:14 to have a bunch of old people who are draining society cost services medicare is going to go bankrupt you know i mean this sounds like a good idea on a personal level, but is it really a good thing to keep people alive forever? Isn't Medicare going to go bankrupt anyway? Well, my next book, Food Fix, I'm going to talk about how we're going to save the world by fixing the food system, including the $95 trillion saved that we're going to save from fixing chronic disease.
Starting point is 01:26:41 Yeah, that'll buy a lot of corn. Yeah. So let's talk about this. We need older people full of wisdom who are fully functional because guess what? If you are not reliant on the healthcare system and you are actually able to contribute to society and to your family and to your friends, it's a very different world and what if everyone listening to the show right now just looked around and said oh my god i might live to 150 would you change the way you take care of the planet you have to if you know you're going to be there for a long time you don't poop in your sandbox yes and if you think you're here you suffer and then you die and it's
Starting point is 01:27:21 someone else's problem later party hard till it's over and yeah the bang yeah and so my wife thinks we're all doomed i'm not so pessimistic i've actually never been more hopeful and and optimistic than i am because i know what the technology is doing not just for anti-aging but for intelligence enhancement for cleaning up the environment, and our ability to access science and to change the world around us rapidly has never been better. So now that we know we have the power, it's just a question of using the power to restore our soil, to reverse the decline in insect populations,
Starting point is 01:27:59 to suck carbon out of the air and put it into the soil. Now, if you're only going to be around for 60 good years and 20 crappy years, and you got to have some kids and build up some economic resources, you know, the next generation get around to that. I'm going to be around for 180 years. I'm just getting going. I just had my 25% birthday mark. I have decades to fix this shit. Someone has to do it. maybe it can be us people who get old i had my 33 birthday there you go right but but this is actually what is like the world is such we have all this cool stuff we have machine learning artificial intelligence we have
Starting point is 01:28:36 lasers we use it right yeah well someone's got to be around to use it right like i'll hold my hand up for that i want i want to get to know my kids and their kids it's okay right so that's why we need older people if we won't fill the planet we'll fix the planet well you know what's interesting is is people do think that it's going to be a cost and a drain and horrible but there's a guy named james frees who did a fascinating study years ago where he looked at people who were healthy in other words who exercised stayed at an ideal body weight and didn't smoke. And he found that they didn't follow the pattern of most people who die. They didn't die slow, long, painful, expensive deaths and cost huge amounts of money and suffering at the end of their life and die early. They actually lived longer and they were healthier and they actually experienced what he calls
Starting point is 01:29:23 the rectangularization of the survival curve, meaning you basically live healthy and then boom, you fall off a cliff as opposed to slow, long decline, which is expensive. So you can die quick, cheap, painless death, or you can die a long, slow, painful death. It depends on how you take care of yourself. So this is what your book is about. It's just an amazing contribution to our thinking and paradigm shifting in terms of how we think about aging and health and in introducing some technologies that people don't think about
Starting point is 01:29:50 that are not part of the normal conversation. And it's so practical. It's full of such great tips. I'm like, it's my bedside companion. And I really mean that, Dave, You are a gift to humanity. Thank you. Your energy, your enthusiasm, your thinking outside the box, your playfulness. I mean, it's pretty freaking awesome that we get Dave Asprey on the planet to help us think differently about how to stay well, get well, and heal ourselves and heal the world. So thank you, Dr. Dave. I mean, you're not a doctor, but I think you are. That's such high praise. Thank you, Mark. Make sure that you get you're not a doctor, but I think you are. That's such high praise.
Starting point is 01:30:25 Thank you, Mark. Make sure that you get Superhuman, the bulletproof plan to age backward and maybe even live forever. It's released October 8th. It's an unbelievable book, and you won't be sorry you got it. And if you would like to share any last words,
Starting point is 01:30:42 not that they're your last words because you're going to have many last words. There's going to be lots of those. If you pick up the book and send the receipt to me, go to daveasbury.com for info. I did an interview with eight of the leaders in anti-aging, stuff that isn't on my podcast. So there's an exclusive audio series.
Starting point is 01:31:02 I'm just giving it away. So give me your receipt to show you about the book, show your support, and this info will be there. Mark, I'll send it away so give me your receipt to show you about the book show your support and the simple will be there Mark I'll send it to you as well now you gave me the book does that mean I have to go in like buy the book now again
Starting point is 01:31:11 to get three copies for you well thank you Dave thank you for your work thank you all for listening if you've enjoyed this podcast and listening to the doctor's pharmacy please share with your friends and family leave a comment.
Starting point is 01:31:25 We'd love to hear from you and subscribe wherever you get your podcasts. And we'd love to hear more from you. And thank you for listening to doctor's pharmacy. And we'll see you next week on the doctor's pharmacy. Hi everyone, it's Dr. Mark Hyman. So two quick things. Number one, thanks so much for listening to this week's podcast.
Starting point is 01:31:46 It really means a lot to me. If you love the podcast, I'd really appreciate you sharing with your friends and family. Second, I want to tell you about a brand new newsletter I started called Mark's Picks. Every week, I'm going to send out a list of a few things that I've been using to take my own health to the next level. This could be books, podcasts, research that I found, supplement recommendations, recipes, or even gadgets. I use a few of those. And if you'd like to get access to this free weekly list, all you have to do is visit drhyman.com forward slash pics.
Starting point is 01:32:21 That's drhyman.com forward slash picks. That's drhyman.com forward slash picks. I'll only email you once a week, I promise, and I'll never send you anything else besides my own recommendations. So just go to drhyman.com forward slash picks, that's P-I-C-K-S, to sign up free today. Hi, everyone. I hope you enjoyed this week's episode. Just a reminder that this podcast is for educational purposes only. This podcast is not a substitute for professional care by a doctor or other qualified medical professional. This podcast is provided on the understanding that it does not constitute medical or other professional advice or services. If you're looking for help in your journey, seek out a qualified
Starting point is 01:32:59 medical practitioner. If you're looking for a functional medicine practitioner, you can visit ifm.org and search their find a practitioner database. It's important that you have someone in your corner who's trained, who's a licensed healthcare practitioner and can help you make changes, especially when it comes to your health.

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