The Dr. Hyman Show - Foods And Habits To Boost Brain Health

Episode Date: November 29, 2021

This episode is brought to you by Rupa Health and InsideTracker.   At every meal, we make choices of what to feed our bodies—and our brains. Too much sugar and refined carbs, not enough good fats, ...inadequate intake of the right nutrients, and exposure to toxins can have a negative effect on our brains and even contribute to disorders ranging from brain fog to depression to Alzheimer’s. Nutrients are the fertilizer for the brain. When we get the right kinds, our brain can flourish and grow, even generating new cells in older age, long after science previously thought was possible. In this episode of my new MasterClass series, I am interviewed by my good friend and podcast host, Dhru Purohit, about using diet and lifestyle to support brain health. We also talk about why it’s important to treat the body when it comes to treating brain issues, and I share my own experience using Functional Medicine to heal my own brain. Dhru Purohit is a podcast host, serial entrepreneur, and investor in the health and wellness industry. His podcast, Dhru Purohit Podcast, is a top 50 global health podcast with over 30+ million unique downloads. His interviews focus on the inner workings of the brain and the body and feature the brightest minds in wellness, medicine, and mindset.   This episode is brought to you by Rupa Health and InsideTracker.   Rupa Health is a place for Functional Medicine practitioners to access more than 2,000 specialty lab tests from over 20 labs like DUTCH, Vibrant America, Genova, Great Plains, and more. Check out a free live demo with a Q&A or create an account here.  Save $200 on InsideTracker’s Ultimate Plan + Free InnerAge and enjoy 25% off as part of their Black Friday Sale here.   In this episode, we discuss (audio version / Apple Subscriber version):    What to eat, and not to eat, for brain health (4:10 / 00:56)  How and why inflammation affects the brain (10:30 /  7:19) Fixing the body to fix the brain (12:59 / 9:45) The importance of exercise, sleep, and stress management (14:46 / 11:21)  Dr. Hyman’s personal brain health story (19:37 / 16:23)  The dangers of environmental toxins (26:08 / 22:32)  Sugar’s effect on the brain (35:58 / 32:42)  Case studies (39:01 / 35:48) Supplements to support brain health (50:09 / 46:56)  Your questions on foods, energy, caffeine, and more (51:51 / 48:41) 

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Starting point is 00:00:00 Coming up on this episode of The Doctor's Pharmacy. If you have chronic stress, it literally shrinks your brain. It shrinks the hippocampus in your brain, which is the memory center. So we know that chronic stress causes dementia. Hey everyone, it's Dr. Mark. I know a lot of you out there are practitioners like me, helping patients heal using real food and functional medicine as your framework for getting to the root cause. What's critical to understanding what each individual person and body needs is testing, which is why I'm excited to tell you about Rupa Health.
Starting point is 00:00:36 Looking at hormones, organic acids, nutrient levels, inflammatory factors, gut bacteria, and so many other internal variables can help us find the most effective path to optimize health and reverse disease. But up till now, that meant you were usually ordering tests for one patient from multiple labs. And I'm sure many of you can relate how time-consuming this process was, and then it could all feel like a lot of work to keep track of. Now there's Rupa Health, a place for functional medicine practitioners to access more than 2,000 specialty labs from over 20 labs like Dutch, Vibrant America, Genova, Great Plains, and more. Rupa Health helps provide a significantly better patient experience, and it's 90% faster, letting you simplify the entire process of getting the functional medicine lab tests you need and giving you more time to focus on patients. This is really a much-needed option in functional medicine space, and need, and giving you more time to focus on patients. This is really a much needed option
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Starting point is 00:01:44 When I began practicing functional medicine over 20 years ago, it was clear to me that we have to look at how unique each body is. And now with technology advancing in amazing ways, we can truly take that concept to the next level. One of the tools that I recently discovered that can help us all do that is InsideTracker, and you can do it from home. It was founded in 2009 by top scientists in aging genetics and biometric data from MIT, Tufts, and Harvard. Inside Tracker is a personalized health and wellness platform like no other. It's purpose-built to help you live a longer, more productive life. Their cutting-edge technology analyzes your blood, DNA, and lifestyle to give you highly personalized recommendations. Then using the app, you can track your progress every day.
Starting point is 00:02:26 Inside Tracker tells you what to do and why. So your health goals are clear and actionable and most importantly, based on exactly what your body needs. My team took Inside Tracker for a spin and they really loved it. They discovered some important things about their health that led them to stop procrastinating when it comes to certain parts of their health.
Starting point is 00:02:44 Like for example, finally taking a vitamin D supplement after seeing they were deficient or eating more iron-rich foods due to low ferritin and hemoglobin and making an effort to embrace stress reduction techniques after seeing their high cortisol levels. This holiday season, why not get your loved ones a gift that is truly special and unique to them? This Black Friday, save $200 on Inside Tracker's Ultimate Plan and free Inner Age, the most comprehensive way to get personalized insight into their body's well-being. Head to insidetracker.com slash hyman to save $200 on Inside Tracker's Ultimate Plan and free Inner Age and enjoy 25% off site-wide to give the gift of
Starting point is 00:03:24 personalized health. And now, let's get back to this week's episode of The Doctor's Pharmacy. Hey everybody, it's Dr. Mark Hyman. Welcome to a new series on The Doctor's Pharmacy called Masterclass, where we dive deep into popular health topics, including inflammation, autoimmune disease, brain health, sleep, and lots more. Today, I'm joined by my guest host, my good friend, my business partner, and host of the Drew Pruitt Podcast, Drew Pruitt. And we are going to be talking about how to boost your brain health
Starting point is 00:03:54 and reduce inflammation using food. Welcome, Drew. Mark, thanks for having me. I'm excited to jump into this podcast. As you know, I started with brain health in my podcast, so I'm excited to jump in. I know it's a topic that people care a lot about. So let's start off with delivering some immediate value to people. Three things that people can eat or potentially not eat that's directly tied into having a better brain. Very important because one of the best ways to access brain health is through our diet, both what we eat and what we don't eat. Let's start with the don'ts. The most dangerous thing for your brain
Starting point is 00:04:32 is sugar and starch. Those cause inflammation in the brain. They cause dementia. They cause depression. They cause behavior issues. They're really nasty for the brain. So it doesn't mean you can't ever eat them, but think about those things as recreational drugs, as I've said. So starch and sugar. The third thing you really want to get rid of is bad fats. So trans fats are very dangerous. They're still in our food supply, even though they've been regulated as not safe to eat, they're still out there. And a lot of refined processed oils. So those would be the things that I would avoid, number one. And of course, processed food. That just kind of goes without saying. And what are some examples of those refined and processed oils that you're
Starting point is 00:05:12 mentioning? So my favorite is what they call vegetable oil. You go to the grocery store and it says vegetable oil. What is it? Broccoli oil? No. It comes from seeds. It comes from sometimes even cottonseed oil, which is highly toxic. It's canola oil. It's soybean oil. 10% of our calories come from soybean oil. It's increased 1,000% in our diet. Didn't even exist as a real food in our diet until probably 1900, early 1900.
Starting point is 00:05:39 So we really entered an era where we are eating a diet that is so different than we have for almost all of our human evolution. And those fats tend to drive inflammation. They're easily oxidized. They go rancid. They're made with extraction processes that have hexane. And they're often causing significant inflammation and damage in the body. And just so people are aware, it's not that they're necessarily going out there and buying these oils and cooking with them. They're in everything. They're in everything.
Starting point is 00:06:08 So you have to be a student of ingredient labels and pay attention to all the processed foods that are out there because a lot of them are going to be fighting against your brain health. Yeah. The easiest trick is just don't eat anything processed unless you know what's in it. Like, I mean, if you have to have a list of ingredients, I mean, yes, there's some packaged food that's fine, but if you have to know what it's in it. So if it says some big chemical words, you can't recognize it, or you've got 14,000 things
Starting point is 00:06:30 on the label, probably not what you should be eating anyway. Great. So those are three things to avoid. And so you were going to go into the topic of three things that we can pay attention to. So most people don't know this, but your brain is mostly fat. You know, we really are all fatheads. And about 60% of our brain is made of fat.
Starting point is 00:06:48 And most of that is what we call DHA or docosahexaenoic acid. Sounds like a big chemical name, but essentially it's fish oil. Comes from algae too. You can get it from algae. So if you're plant-based, you can get it from algae. But it is the main ingredient for a healthy brain. And so we need to be eating fatty fish that's low in mercury. We need to be eating algae. We need to be doing things that actually help boost
Starting point is 00:07:09 our DHA levels. The second thing is good fats in general, because our brain actually responds really well to fat. MCT oil, for example, is the derivative of coconut oil that's really great for the brain's energy system and can help improve cognitive function. It also improves athletic performance. The third category of foods we should be focused on are phytochemicals. There's 25,000 compounds in plants, maybe more. The Rockefeller Foundation is now doing the periodic table of phytochemicals. They're spending hundreds of millions of dollars to map out the medicinal properties in these foods. But it's really easy when you think about it. Just eat the rainbow. If it's colorful and it's not Skittles, it's okay to eat. So all the dark colored vegetables,
Starting point is 00:07:49 greens, blues, purples, reds, yellows, those foods that contain these pigments are full of these phytochemicals. And they're really extraordinarily helpful in regulating brain function in so many different ways. As a bonus one, how about hydration? It seems like that's one area that's often overlooked. You know, one of the things that often people forget about is the bottom of the matrix in functional medicine, which is the sort of the map we use to figure out what's out of balance for people. And hydration is really, really important because most of us walk around dehydrated. Most of us don't drink enough water. We have other fluids like sodas and juices and coffees and teas, but we don't really have enough water. And often when we do, we're not getting intracellular hydration, which is so critical.
Starting point is 00:08:35 So not only in your bloodstream, but inside your cells, which is what makes you feel good. So it gives you energy and performance. So my favorite athletic performer is Tom Brady and he never drinks water without electrolytes. Maybe that explains his seven Super Bowl rates. I don't know. But I agree. Using electrolytes in your water is so important and not the kind with tons of sugar and all kinds of weird stuff. My favorite one, I have no affiliation with this brand, it's called Light Show, L-Y-T-E Show. But it's simply liquid drops you can put in a glass of water. And every time I drink, I try to add those in. And there's a portable container you can take your little drops with
Starting point is 00:09:12 you. So intracellular hydration is really, really important. And it's important for your cognitive function. It's important for energy. It's important for everything. One caveat on water, naturally, as the world, and especially here in the United States, unfortunately, too, has more and more infrastructure challenges, more of the water that's out there is corrupted. So just another reason that people should really invest in a high quality filter. I heard somebody say one time, either you get a filter or you become the filter. That's a good one. Yeah, I think it's right. I mean, I remember reading a paper recently that showed that in the average tap water, there's 38. I mean, I remember reading a paper recently that showed that in the average tap water,
Starting point is 00:09:50 there's 38 wastewater contaminants, pesticides, glyphosate, medications. I mean, where do you think all the women taking birth control pill or hormones or Prozac or statins, those get metabolized and they get excreted in the urine. Where does that go? It goes into our water supply that gets filtered, cleaned, and reused. And we ended up having all these wastewater contaminants and people don't have a clue about what they're drinking. Forget about the chlorine and the fluoride and all the other stuff that's added to the water. But there's a lot of inadvertent things in the water because of the level of toxicity in our society.
Starting point is 00:10:14 So I think filtering water is so key. Obviously, if you're drinking water, bottled water is a problem because one, it's usually plastic, which is not something we need more of in the world. Glass bottles are okay, but getting a filter is really important. So let's zoom out really quickly. How big of a problem is poor brain health and inflammation of the brain really? That is a very important question because a lot of the diseases that we see that are causing disability, loss of productivity,
Starting point is 00:10:47 loss of quality of life, are brain disorders. Whether it's anxiety, depression, the opioid epidemic, neurodegenerative diseases like Alzheimer's, Parkinson's, and all the cognitive disorders like ADHD, autism, these are all diseases of inflammation of the brain. And they're rampant. If you look, for example, just at depression, our modern tools really suck at treating it. I mean, if you have severe depression, sometimes medications can help. But for most people, you look at the data, it may be 30% effective, not much more than a placebo. And the question is, what's driving that problem?
Starting point is 00:11:25 It's all our inflammatory lifestyle, which we've talked about a lot on the podcast. And it's one of the most important things. One in four people have a severe episode of depression in their life in the world. It accounts for the majority of the costs in our healthcare and all the collateral symptoms that we have from the externalities of depression, like loss of productivity. So there's a macroeconomic analysis looking at over the next 30 years, what's it going to cost for chronic disease? It's $95 trillion with a T, okay? That's a lot of dough.
Starting point is 00:11:56 That's way more than the GDP of the top nations in the world combined, probably twice that of all the top six nations combined. That amount of money, the majority of that is for depression because of the loss of productivity, the effect on society, and so forth. So these are rampant conditions. One in 10 kids have ADD. Alzheimer's, we probably have Alzheimer's or pre-Alzheimer's in 40, 50 million Americans. Depression affects more than 60 million people, but throughout people's lifetime, it's super common. We're seeing rampant increases in autism and neurodegenerative diseases. So we have to grapple with this problem of brain health in a more focused way because it is the thing that we need to operate in our lives, to be happy, to have healthy relationships, to do the work we want
Starting point is 00:12:41 to do in the world, to be a functioning member of society, to be engaged and not just be in a spiral of a near vegetative state sitting on the couch watching TV because you feel like crap. So there is enormous opportunity to sort of pull the veil back and rethink our whole approach to brain health. Now, one of your first books was Ultra Mind Solution. And one of the core ideas in that book was what you do to the body, you do to the brain. Can you expand on that? What did you mean by that?
Starting point is 00:13:08 Well, the title of the book was The Ultra Mind Solution, How to Fix Your Broken Brain by Fixing Your Body First. Because unlike what we learned in medical school, which is that our head and brains are sort of this disembodied thing on the top of our shoulders, and it doesn't connect with anything that's going on below there, we've learned that that's completely untrue,
Starting point is 00:13:29 that we're learning that the brain responds to everything we do, what we think, what we feel, exercise, sleep, our diet, environmental toxins, stresses, all these things influence our microbiome, everything influences the brain. So we really have to sort of think about how do we re- of equilibrate to a different way of thinking about brain health based on all the things that we can do to fix the imbalances
Starting point is 00:13:52 in the body that affect the brain, whether it's thyroid, whether it's your microbiome, whether it's toxins, whether it's low nutritional levels of certain vitamins and minerals like fish oil or omega-3s or vitamin D or the B vitamins. So we know a lot about the things that make the brain healthy. We call these trophic factors. These are things that help the brain grow and improve and increase neuroplasticity and neuroconnectivity. There's so much that's exciting that we know about how to do that. And yet most of us are poisoning our brains and we think, oh, I know I have for my heart, I have to exercise, I have to cut out saturated fat, I have to do all that and I can prevent heart disease.
Starting point is 00:14:28 But most of us have no clue how to take care of our brain or live a brain healthy lifestyle. We just don't learn it. What are a couple examples of things that people are doing today, separate from like the topic of foods, right, that are some of the biggest contributors to poor brain function in their life overall? Well, the low-hanging fruit is lack of exercise. 8% of Americans get adequate exercise. That leaves 92% who needs some help.
Starting point is 00:14:55 And the exercise is really extraordinary because when you do cardiovascular exercise, when you do strength training, when you do HIIT training and specific kinds of exercise, it increases these incredible molecules in your brain called BDNF. BDNF stands for brain-derived neurotrophic factor. Think of it like miracle grow for your brain. So when you exercise, you're literally increasing the number of brain cells, you're increasing the connections between the brain cells, you're increasing your cognitive power. Exercise is super critical. So that alone can make a huge difference for so many people. The second thing is sleep.
Starting point is 00:15:31 If we don't sleep, our brains don't work. And I remember the study I read recently that looked at sharpshooters in the military, the snipers essentially, who were super accurate, like 99% accurate when they have eight hours sleep. When they get seven hours, drops off a little, maybe 90%. Less than six hours, starts to go to like 60, 50%. Under six hours, it's like basically hit or miss. It's 50-50. And so we really don't understand how important sleep is to cleaning our brain, to repairing our brain, to getting rid of the garbage. The garbage man
Starting point is 00:16:05 comes at night when we're sleeping to clean out all the metabolic waste that our brain makes during the day. And if you don't have adequate sleep, you're not going to be able to do that. The third thing, in addition to exercise and sleep, is stress. We know that chronic stress, now we all have acute stresses, but the chronic unmitigated stress of our modern life, and whether it's coming from the world we live in and all the chaos, whether it's coming from inflammation and stress that our diet causes, because our diet literally causes us to build more adrenaline and cortisol in our body, like high starch and sugar diets, whether it's our sedentary lifestyle,
Starting point is 00:16:36 all these things drive our brains to not function properly. And so the stress response is something we know how to deal with. We know how to actually reset the body by activating the part of your nervous system that is the relaxation response. We call that the parasympathetic system as opposed to the fight or flight or freeze response. It's playing possum, basically. And it's not just sitting on the couch watching TV, drinking a beer. It's actually a very active thing. So it could be meditation. It could be yoga. It could be my favorite or more passive ones like massage, hot and cold plunges. There's a lot of ways to access the nervous system to help
Starting point is 00:17:17 reset it to create a deep sense of profound relaxation that's physiologic and that helps repair your brain. Because if you have chronic stress, it literally shrinks your brain. It shrinks the hippocampus in your brain, which is the memory center. So we know that chronic stress causes dementia. So just that alone can have a huge impact, those three things. And then there's a huge long list that goes on and on. But Dale Bredesen, who, one of my favorite people, he's an incredible neurologist who studied Alzheimer's and has used functional medicine to reverse, not just to stop or slow, but to reverse Alzheimer's in patient after patient. And he talks about this idea called a cognoscopy, which is how do we, we get a colonoscopy,
Starting point is 00:18:00 but how do we measure our brain function? Well, there are some really specific, simple online tests, neurocognitive tests you can do. There are ways of looking at brain imaging. There are certain lab tests and things you look at to see what are the threats to the brain. How do you assess the threats? And it's important because when you start to understand how the brain works, you can really play with it and see conditions reverse that you just never would see. I mean, I only wrote Ultra Mind Solution because I was treating people's physical problems. And as a side effect, their brains would get better. And I'm like, what happened? Like someone, for example, would be
Starting point is 00:18:37 having panic attacks and anxiety and depression. And I would get their insulin under control and their microbiome under control. And they go, well, I don't have that anymore. I'm not depressed. I'm not anxious. Or they had bipolar disease. And I did this and this and this and it got better. Or they'd have ADHD or autism or Alzheimer's. And they start to really improve or completely recover. I'm like, what's going on here?
Starting point is 00:18:58 This is not what I learned in medical school. And so I began to really, through the inquiry of my own patients and their data and their experiences in applying functional medicine, was able to sort of map out how all this connects and all the things that affect the brain. And it's not just the obvious things, but there's a lot of things that we can dive into around infections and the microbiome and toxins and other things that affect brain health. So the fundamental things are easily accessible to everybody. And we all should think about not only how do we take care of our body and our weight
Starting point is 00:19:31 and our heart risk, but also our brain health. And there's some very specific things you can do to do that. Now, this topic is near and dear to you because you write in your book that not only were you focused on helping your patients, but you were trying to help yourself. Your own brain broke. So I'd love for you to take us down your story. And also, while you go through it, help us look at the whole topic of brain-related disorders
Starting point is 00:19:55 and how conventional medicine might see it and how functional medicine might see it. First, I'll start with my story because it helped teach me so much about how the brain breaks and what to do to fix it. When I was in college, a student got in a medical school. School was easy for me. I barely studied and my brain was just like a steel trap. And I remembered everything, could focus, pay attention, was happy. I mean, my brain was good. I exercised, I ate healthy. I did all the right things. I did
Starting point is 00:20:26 yoga. And then I went to China and got mercury poisoning, which I didn't know at the time, came back and got some other insult that tripped my system into really being sick. And all of a sudden I went from completely functional to completely dysfunctional. I couldn't sleep. I. Even though I was exhausted and had chronic fatigue syndrome, I couldn't focus. I was like, I had ADHD. I couldn't remember anything. I got depressed. So it was like I had depression, ADD, and dementia all at once. And I would literally be reading my kids a story at bedtime and I couldn't understand the sentence. If I read it out loud, I literally would not be able to understand what I was saying.
Starting point is 00:21:11 My brain didn't work. Or when I was talking to somebody, I would start a sentence and I didn't know where I, I didn't really know where I was going. I couldn't finish the sentence. I was really damaged. And so through understanding my own biology and reverse engineering my way to health, I began to understand all the factors that affect brain health. And that's really why I wrote The Ultra Mind Solution, because it's what I learned on myself, but it's also what I began to see on nearly thousands of patients. Talk to us about some of those root factors that were going on for you that might be beneficial for other people to hear. What was going on in your life that contributed you to being in that place in the first place?
Starting point is 00:21:47 Well, I had a bunch of stuff. I mean, I was in a crazy work schedule. I was working as a ER doctor after I came back from China, not sleeping. I literally was doing 15 shifts a month. It doesn't sound like a lot, but it's a lot. And I was staying up all night, many, many nights. I was taking care of my two kids my ex-wife was an alcoholic and it was really a tough moment a lot of stress and a lot of work and a lot of sleep deprivation and then i would you know go to the emergency room and i would have an 11 o'clock to 7 a.m shift at night and i would drink a quadruple espresso a giant chocolate chip cookie and a half a pint of ice cream and i'd get in the car and I'd drive to work. And I'd last probably until five in the morning.
Starting point is 00:22:25 Hopefully it was quiet enough I could take a nap. And I did that for years. And so between that stress, between the difficult stress in my life in terms of my marriage, and also this underlying mercury toxicity that then got tripped into full expression when I had a severe intestinal infection. That was sort of the straw that broke the camel's back and ended up just cascading into years and years of me trying to figure this out. And I got terrible diarrhea for years, SIBO, bacterial overgrowth. My muscles were getting damaged. My immune system was dysregulated. I started getting sores on my tongue, rash all over my body, autoimmune antibodies.
Starting point is 00:23:02 My liver function went up. I mean, my whole lab tests looked terrible and I was a mess. And doctor after doctor was like, well, you're depressed, take Prozac or you're anxious, take Xanax or you can't sleep, take Ambien or, you know, it was like, it was that. And I remember, and I started getting weird fasciculations and all kinds of weird symptoms and my muscles were twitching and my muscle enzymes were really high, which means my muscles were being damaged. And I remember going to Columbia and seeing these top neurologists, who's an expert in this type of thing. And they ordered a test called the EMG, which is no fun. Essentially, they stick giant needles in your muscles and they then send electrical currents down them to see what's going on. And guy was this old british doctor there who was running the
Starting point is 00:23:45 test and he said oh you have been benign fasciculations which means your muscles twitch but it's not serious it's not als which because it could it could have been als and uh and the uh and he goes off the record this isn't normal like there's no such thing as benign fasciculations you don't have LLS, but it's something else. And I thought, oh, you know, so that, and that was even before I figured out the mercury thing. I just, I just didn't know what was going on. I was searching and searching and searching. So it took a couple of years for me to actually figure out the mercury thing before I was able to get better. What was part of that turnaround process,
Starting point is 00:24:20 which also was the introduction for you into the world of functional medicine? Like how did you begin to look at things differently and then start to treat yourself? Well, I was always a little weird. I studied nutrition in college and was a yoga teacher before I was a doctor. I was interested in integrative health. I didn't even call it that then. And I was always exploring the edges, studied ancient healing systems, Chinese medicine. So I always had a different framework that I was coming from when I went to medical school. And then when I got a job at Canyon Ranch, it's right when I got sick. And I met a woman named Kathy Swift, who was a nutritionist there. And she's like, you got to come to this lecture from Jeffrey Bland. And I'm like, okay. And so I went to hear
Starting point is 00:24:58 this guy speak and I listened to him and I thought, this guy's a genius or he's a lunatic. And if what he's saying is true, it means that everything I learned needs to be re-examined, questioned and re-imagined. And I need to prove that to myself and my patients. So I said, I'm going to try it on. Because if he's right, it's a game changer. If he's wrong, he's just a nut who's promoting a lot of stuff that's kind of goofy. And it turned out he was right. And the rest is history. And that's when we really started diving into functional medicine at Kenya Ranch. We had a great incubator where we could spend hours with patients. I could dig in all these things. I could learn everything. They were willing to do stuff. And so it was
Starting point is 00:25:38 really a great incubator. And then I just kept going down that rabbit hole and healed myself and started healing thousands and thousands of patients. So what was one of the first things, and we're going to touch on your story, but these are also things that people can walk away with when it comes to their own story too. So what was one of the first things that you did when it came to your diet? You're eating chocolate chip cookie, double espresso, you know, you had all this sugar in your diet. What was one of the first things you did when it came to your diet? Well, I literally had to do an elimination diet because the mercury not only affected my brain, it affected my gut, which by the way, they're totally connected, right? There's called your second brain.
Starting point is 00:26:13 There's more neurotransmitters in your gut than in your brain. There's more nerve endings in your gut than your brain. It's really quite fascinating. And my gut was a mess. And so I developed leaky gut. I developed SIBO, which wasn't even a thing at the time, small intestinal bacterial overgrowth, fungal overgrowth. I would eat anything and my stomach would just blow up like a balloon. Like I had gas, it just wouldn't come out. And I felt
Starting point is 00:26:35 like I was, you know, like a giant sort of tire inflator that just blew up my intestines. And it was painful and difficult. And I had diarrhea and I just had food in my stool. It was just kind of a mess. So I literally had to dramatically change my diet to just be able to tolerate any food. So I used turkey, broccoli, and brown rice for like a year just to kind of calm my system down. It didn't really help get rid of all my symptoms, but it just helped them not be so bad. And until I got rid of the mercury, my gut couldn't heal. And it's not that you're necessarily recommending the turkey, brown rice diet to other folks. You're just talking about what you did. I'm just saying like my system was so dysregulated. I couldn't eat anything without
Starting point is 00:27:15 causing a rash or my eyes like turning like a raccoon black or swollen tongue or my whole system was just messed up. And in order for me to just reduce my diet to the most simple foods that were not going to be triggering reactions, I had to really simplify my diet. So that's what you did then. If you were your patient today, what would you do for that person in that same situation when it came to the topic of diet? If I had me as a doctor when I first started this, I would have been better a lot faster. But I literally had to crawl my way through knowing.
Starting point is 00:27:51 And by that, it was really tough, Drew, because not only was I sick, but it was very hard for my brain to work. So I literally had to, despite having my brain barely functional, still try to learn and focus enough to try things. And it was really tough. It was really, really tough. It's like kind of like trying to like, you know, get out of a very deep hole and a black hole. And it was tough because I didn't,
Starting point is 00:28:18 I didn't have the full capacity of my mind. So I started to learn things and I started to incorporate things. It was very slow. And it took me a number of years before I even figured out that I had mercury poisoning and I ended up sort of being in a functional medicine conference and I met a guy on a plane who was a naturopath and he was he was like well come into my office because maybe I can help you I told him what's going on so he did this machine this electrodermal screening which sounds like total quackery but it's looking at the bioenergetics of different meridians and different electrodermal, electromagnetic frequencies in your skin, which are there. And he said, well, it seems like you have metal toxicity. I'm like, really? Okay. And then I went to my friend, Mark David, and I said,
Starting point is 00:28:57 I was just staying at his house. I'm like, can you do my hair analysis and see what's up? And he took a little hair. We sent it off and it was really high. And then I did a challenge test and I found I had a level that's, you know, I've done, I've probably done 20,000 of these tests over the last 30 years. And it was probably in the top, top 10, 20 tests I've ever seen of the worst levels. And then I, then that was when I started to detoxify, but it was really tough because I didn't have a roadmap. I was just sort of figuring things out. We didn't even understand what SIBO was back then. We didn't understand a lot of things that we know now. And we didn't have a lot of the tools we have now. So that would probably be a lot better, a lot faster. So you mentioned mercury. You know,
Starting point is 00:29:32 mercury is part of these environmental toxins that are out there and it can come from a lot of different sources. We'll touch on that in a second. But mercury is part of a ton of chemicals that are in the environment, like these PUFAs ton of chemicals that are in the environment like these uh poofas forever chemicals that are there we have uh mold that can be environmental toxins with all the flooding and the buildings that we have um do you think that people are paying more attention to this topic than you've ever seen before about how environmental toxins can play a role in things like brain inflammation yeah i think there's more and more literature about the role of environmental toxins in neurodegenerative diseases and autism and ADD in depression. So there's more and more science
Starting point is 00:30:13 around this. So I'm very hopeful. But I do think it's still pretty much ignored. I think people aren't really trained in medical school to understand toxins other than acute toxicity. So chronic low-level toxicity that eventually overwhelms your system is just not something that's even in the field of view of traditional doctors. So for example, I had this patient recently who had non-immune disease, but she had very high levels of lead in her blood and the highest level of lead I'd ever seen in any patient in 30 years. And it was causing all kinds of cognitive and also inflammatory symptoms. And the traditional doctors don't know how to look for that and test for that. They can check a blood test, but they rarely do that. But even if the blood test is normal,
Starting point is 00:31:02 you can still have a lot of stored toxins if you don't have current exposure. So if you don't, for example, if you don't eat fish for three or six months, your blood levels will be good, but you're going to have tons of stored levels in your body. I remember reading a New York Times article about a group of soldiers that made their way to the Cleveland Clinic. Yeah. And can you tell that story? Yeah. Well, you know, the special forces guys are really not wimps. You know, these guys are Navy SEALs who stand in ice water for three hours and, you know, one run a hundred miles. I mean, these guys are just superhuman. And it was a whole group of these guys who were really sick and they were being kind of dismissed by the defense department and the VA. And one of them
Starting point is 00:31:43 came to Cleveland clinic and I said, well, let's look at your story. What's going on? You're cognitively impaired. You can't focus. You're depressed. You're overweight. Your metabolism is messed up. You have all these other symptoms. Let's just see what's going on. So I said, what do you do? He says, well, I'm a blast expert. I blow stuff up and I teach other people how to blow stuff up. And we do it in enclosed buildings. And when you blow stuff up and you make bombs and guns, you release lead mercury into the air. And they're in there in a closed space with poor filtration. They're breathing it in. So you do this long enough, you start to become poisoned. And they came in and they were poisoned. And I was able to help these people get better. It was really pretty miraculous. And one of the story in
Starting point is 00:32:22 the New York Times was about this one soldier who went to, I think it was Mount Sinai, where they have the lead expert who uses a very specific technique. It's only kind of in research, which looks at the bone lead levels, which is kind of the best kind of measure of total body lead. And this scientist, doctor, I think it was at Mount Sinai, said, look, we see this, we can measure it, but we never see it go down. But when these patients came back to me after being treated, not only were they clinically better, but their levels of lead in the bone went down.
Starting point is 00:32:55 I've never seen this before. And of course, you've never seen it before because most of us were never trained on how to detoxify patients from heavy metals. But when you know what to do, you can remove the metals and these people get better. So now we have a whole group of people working with us from the Department of Defense and Special Task Force Dagger to incorporate these ideas into the VA and the Department of Defense healthcare system. So before we get back into neuroinflammation overall and brain health overall, let's just put a button in the topic of mercury and lead. For most people, it may not necessarily be the first thing to look at unless if they're
Starting point is 00:33:31 working with like a functional medicine doctor. So most people who are listening are wondering like, wow, do I have mercury? Do I have lead? It's an important topic to pay attention to. It's probably something that you need to be guided down the path of working with a trained practitioner who knows about that area. And I think it's important to say, look, with brain disorders, whether it's the mood disorders, anxiety, depression, whether it's the tension of cognitive disorders like ADD and autism or the spectrum, whether it's the neurodegenerative disorders like Alzheimer's, Parkinson's,
Starting point is 00:34:00 there are many factors that drive those problems. And you have to look at all of them. Mercury is just one. Lead is just one. Those are final common pathways for multiple insults. So if you take 10 people with depression, there may be 10 different causes. For some, it might be metals. For another, it might be a low vitamin D level or the fact that they've taken antibiotics
Starting point is 00:34:21 and screwed up their microbiome. Or maybe it's because they're taking an acid blocker and have low B12, or maybe they have gluten intolerance and have dealt with antibodies against their thyroid, which causes depression. So there's a lot of ways to get to the same end disease. So I always say, just because you know the name of the disease, it doesn't mean you know what's wrong with you. Just because you have a label, it doesn't mean you know the cause. And the problem with modern medicine is what we call the name it, blame it, and tame it game. We name the disease. Oh, you have low mood. You're crying all the time. You're not interested in eating. You don't want to have sex. You can't sleep. You want to kill yourself. Oh, I know what's wrong with you. You have depression.
Starting point is 00:34:56 But that is not the cause of your symptoms. Depression isn't the cause of your symptoms. It's the name of your symptoms. And then we blame the name for the problem. Oh, the reason you have these symptoms is because you're depressed. And the treatment is an antidepressant. So we name it, blame it, and tame it, as opposed to what I call thinking and linking, which is where we start to begin to think about the cause, not just wait for people to sort of get on medication, see what happens. It's really a very important thing to understand for people that the same diseases can have many, many causes and the same causes can create many diseases. So mercury could cause autoimmune disease,
Starting point is 00:35:31 can cause gut issues, can cause depression, can cause Alzheimer's, can cause autism, but not all cases of autism or depression or Alzheimer's are caused by mercury. So you have to kind of think about this kind of framework of one, just because you know the name of the disease doesn't mean what's wrong with you. Two, one cause can create many diseases and one disease can have many causes. So it's a really different framework for understanding human biology. Let's go back to one of the first things you talked about, which was sugar. Help us really understand how sugar is so deeply tied into this whole field of neuroinflammation
Starting point is 00:36:04 and poor brain health. What is it that sugar is actually doing in the body? Okay, you got a couple hours? I spent my life studying this and I'm going to try to synthesize it. But sugar is not necessarily bad. If you have a cookie or if you have a little bit of this or that once in a while, it's not going to kill you. It's the dose that we have. We used to have historically 22 teaspoons a year as hunter gathers. That means if we got lucky, we find a honey, like a honey hive and we can get the honey
Starting point is 00:36:36 or we might find some berries in the summer and we'd get some sugar. But historically, we didn't really have sugar as part of our diet. In 1800, we had 10 pounds of sugar per person, which was still a lot. And now in 2020, we have about 150 pounds of sugar per person per year. So sugar, when you have it at that pharmacologic dose, is a poison. And it does a number of things. One, it screws up your microbiome. So it fertilizes all the bad bugs that create inflammation. Then that creates a leaky gut and that creates neuroinflammation.
Starting point is 00:37:11 It also drives a process in the body called insulin resistance, which means your body's resistant to the effects of insulin. It's like the boy who cried wolf. You eat a lot of sugar and starch and your insulin's go higher and higher and higher and the cells become resistant to the insulin. So you need more and more insulin. But the consequence of that increased insulin is that you get more fat storage in the abdominal fat and the belly fat. And those fat cells are not just there holding up your pants. They're very special kind of fat cells. They're not like the fat in your butt or in your thighs or whatever. They're highly active organs. They produce hormones. They produce cytokines. You've heard of the cytokine storm active organs. They produce hormones.
Starting point is 00:37:47 They produce cytokines. You've heard of the cytokine storm from COVID. They produce all kinds of inflammatory molecules like IL-6, IL-1, and tumor necrosis factor alpha. These are very powerful inflammatory molecules that are coming from your fat cells. So that drives systemic inflammation throughout the body and you get neuroinflammation. Third, we now know that in Alzheimer's disease that there's a huge problem with glucose metabolism and it's insulin resistance of the brain for many patients. Not all Alzheimer's is insulin resistance of the brain, but they're calling Alzheimer's type 3 diabetes now because of this impact of insulin resistance in the brain.
Starting point is 00:38:22 So there's a lot of ways and pathways through which this causes a problem. And I'm not saying never have sugar. Of course I have sugar. It's just, what is the overall balance of your diet? Is this a staple? Is this a daily commodity that you're drinking for breakfast, lunch, and dinner? I mean, in America, we have sugar for breakfast, lunch, and dinner. It's in our cereal. It's in our salad dressings. It's in tomato sauce. I mean, there's more sugar per serving of tomato sauce than there is in two Oreo cookies. So we've got to get kind of real and get all the hidden sugar out of our diet. I'd love to give, you were so kind to share your own testimony earlier and some of the things that worked for you.
Starting point is 00:39:00 Let's talk about a couple other case studies from your practice of people you've worked with. Let's start first with the topic of depression. Any case study that comes to mind? Well, I remember this one patient who was severely depressed. She was in her early 30s, an executive coach, and really struggling. And she had crippling depression. She also had sinus problems that were intractable. She was overweight. She was very inflamed. She had a lot of gut issues. She had tons of yeast overgrowth, and it was kind of miserable. And she came to see me, and I took a look under the hood and found that she had a lot of inflammation in her body that was
Starting point is 00:39:47 secondary to high levels of mercury. This patient had really high levels of mercury, like 300, which is, mine was 187. This was off the chart. And the mercury was causing the weight gain because it's a metabolic toxin. It was causing the gut dysfunction because it poisons the gut. It caused the yeast overgrowth, which is because the mercury causes yeast overgrowth and it caused her depression. And so we systematically treated her by cleaning up her gut and the yeast, by clearing up mercury. Her sinuses got better. The weight came off. Her depression went away. And it took a number of years to get that much mercury out of her body.
Starting point is 00:40:26 But I just saw her after 10 plus years, and it's amazing. She's still doing great. So the beauty is that you can take people with really intractable problems if you know how to navigate to the cause, which is what functional medicine does. You really can make a huge difference for these patients. How about a kid or children with a brain disorder? Somebody that you have a case study that you've worked with before. Well, I have an autism case. That's a long story, but I've seen kids with autism get completely
Starting point is 00:40:54 better using this approach because when you look at brains of autistic kids or people with ADD, they're inflamed. There's a whole immune system in the brain called the microglia, and they can create an inflammatory process in the brain. And on MRI scans, you literally see large brains, swollen brains on these kids. When they do autopsy studies of kids with autism for a diet and a car accident or something, they'll see their brains are filled with these inflammatory cells and they're inflamed. So the question is, what's causing that inflammation? And kids with autism are like the canaries in the coal mine. This one kid I saw was 22 months old when he started getting symptoms. He had regressive autism and he had a lot of antibiotics early on. You hear
Starting point is 00:41:36 the same story, C-sections, lack of breastfeeding, early antibiotics, and then maybe getting vaccinated when they're sick. I'm not saying vaccines cause autism. I'm just saying that it can be part of the mix that triggers a dysregulated gut and immune system to go haywire. And there's a whole field of vaccinomics, which is fascinating, which is looking at how individuals respond differently to vaccines. So this kid had terrible gut symptoms, sticky, smelly poops. He, you know, was nonverbal at two and a half.
Starting point is 00:42:04 He couldn't look at you in the eye. He was just a mess. All the classic symptoms of autism. I was told by the doctors, just give him some behavioral therapy, good luck, and eventually ended up in an institution because he had really severe autism. So all I did was what I normally do is I did my analysis of what are the factors that cause disease? What are the factors that are needed to help thriving in health? What is he missing? What does he need to get rid of? Basic functional medicine approach. We found he had terrible gut disposal. He had three species of yeast. He had leaky gut. He had bacterial overgrowth. He had massive nutritional deficiencies in vitamin D and zinc and magnesium and the B vitamins, B6, B12. And he had a significant
Starting point is 00:42:46 mercury in his system as well. So he began to treat these things and we got rid of the metals in his system. We fixed his gut. We cleared out the bad bugs with antibiotics and antifungals and we reset everything. We gave him all the nutrients he needed and B12 shots. And this kid literally became normal. And I was like, whoa, this is crazy because I learned that autism is not reversible. Now, that's not to say that every kid will respond this way because there are many factors. And I've seen kids with autism that have more fixed problems, for example, genetic. And I look at all their lab tests and they're normal. I'm like, I don't know what to do because they're normal.
Starting point is 00:43:21 So there is a way to navigate the brain health field by looking at all these factors. And I've had kids with ADD that completely normalized by simply getting them the things that they need for their bodies and their brains to thrive. Let's do another one. And that's on the topic of, you shared about Alzheimer's earlier and sort of Alzheimer's, dementia, all the neurodegenerative diseases that increasingly more and more people are suffering from. You had a patient that came to you and was a referral over who was a gentleman that was running a company and was thinking about retiring early because his brain was so messed up. Talk to us about that.
Starting point is 00:44:02 Yeah, he was 70 years old and he was in the book, Ultramind Solution. It was one of those cases that I had to sort of like rethink everything about. My wife brought him in to look. My husband is basically non-functional. He's a CEO of our company or a family-held business. He now sits in a room alone, depressed and demented. And the kids don't want to be around him. The grandkids are scared of him. He's just not the human he was. Can you do anything? I'm like, I don't know. Let's try. So from the functional medicine perspective, the beautiful thing about it is that it doesn't matter what disease you have. You treat the system, you normalize function, hence the word
Starting point is 00:44:41 functional medicine, and you see what happens. And usually the diseases get better. So it turned out that this guy had a lifelong history of gut issues. He had irritable bowel, terrible bacterial overgrowth. He was on a drug called Stelazine for 30 years because his gut was such a mess. And it's an antipsychotic tranquilizer drug that was calming his gut down, which is kind of amazing. He also had the ApoE44 gene. So he had some genetic setup for this, which is the Alzheimer's gene. He had also genes that affect his B vitamins called methylation. And he had a very high homocysteine, which is an important nutrient marker of folate or B6 or B12 deficiency. And when you look at the data, if your level's over 14, you have a 50% increase of Alzheimer's. He also had significant heavy metals. And I don't
Starting point is 00:45:27 mean to be harping on heavy metals, but they are a big thing and a lot of brain damage. And they're one of those things that their doctors don't know how to look at. They don't know how to test. They don't know how to diagnose. They don't know how to treat. So it's really a problem. You need to see a functional medicine doctor. And he lived in Pittsburgh. And all my patients from Pittsburgh are mercury poisoned. Why? Because US Steel is there. All the steel plants use coal to actually make the steel. Coal ash is often used in Pittsburgh to cover the roads from ice in the winter to put on fields. It's in the air pollution and his level was just off the chart. Plus he had a mouthful of mercury. So we did an aggressive medical treatment on him that fixed his heavy metals, that fixed his gut,
Starting point is 00:46:07 that optimized his nutrient status. And he also had prediabetes. So he's a skinny fat guy. He looked thin, but he actually had this little belly and he was prediabetic. And we got him on a low-start sugar diet, cured his insulin resistance. So he had B vitamin issues, he had gut issues, he had metal issues, he had insulin resistance, prediabetes, and we fixed all that. And he went from being completely non-functional to back running his business, engage with his family and friends, and reversed the cognitive symptoms that he had. It was really a miracle. And the neurologist that I sent him to at Harvard to do all the imaging and the brain scans and stuff that
Starting point is 00:46:41 we couldn't do was so impressed by the results that he then started a center for brain health at Harvard. So it's amazing what you see happen with these patients. So as you mentioned, sometimes a person might need to work with a functional medicine doctor, but a lot of times people can take steps and head in the right direction just even through a little bit of self-guided and in some cases at-home testing. So I want to talk about testing and are there any tests that are out there? You mentioned genetics, for example. You also mentioned omega-3s and getting more of those in your diet.
Starting point is 00:47:16 There's like a simple at-home test that people can do. We have no affiliation with them that they can see their omega-3s. So give a few of these at-home tests and your thoughts in general about them and if they can be part of the puzzle pieces for people to figure out how to get to the root causes that are going on with them. Well, it's interesting. I see a lot of companies popping up that are focused on home health testing, that are focused on giving access to their data for people that are creating companies that are allowing people to start to do the diagnostics themselves and be part of a sort of a self-care process that often, you know, we surrender to our doctors. And so there's a lot we can do ourselves. I believe that people should be empowered with their health
Starting point is 00:47:56 information. They should be empowered with their diagnostic test. They shouldn't be just sold, your tests are okay and I'll see you later and come back next year. And they can actually start to look at some of these things. The current landscape of self-testing is limited now, but there's things you can do around food sensitivities. There's things you can do around hormones. There's things you can do around, you know, gut testing. So there's stuff that's starting to come out. I don't think we're quite there yet for everybody.
Starting point is 00:48:22 There's genetic tests like 23andMe. So people can get a sense of what to do. But what would be more exciting for me is some of the companies that are coming out creating 360 solutions, where they're doing diagnostic questions. They're kind of guiding them on what you should do and how to fix these things. I think we're not quite there yet, but we're going to get there. And what do you think about continuous glucose monitors and their ability to be a part of the process of people figuring out what diet is right for them. Right. So before in measure your blood sugar, you had to go get a blood test with a regular needle or you have a finger stick test, which is annoying and painful and you have to machine.
Starting point is 00:48:54 They've developed these new technologies called continuous glucose monitors, which are little patches you put on your skin with a tiny, tiny little needle. It goes into the skin and there's even more advanced ones coming out that are just going to be like going through your skin. You don't even have to put a needle in. And they measure your sugar continuously. And so you can see what's affecting your blood sugar, what's making it spike up and down. And you can know, oh gee, I'm eating this. If I eat this, if I eat a plum, my sugar goes crazy. But if I eat a blueberry, it doesn't. Or if I have this, you know, meal in this way or that way, it affects what if I have a blueberry, it doesn't. Or if I have this meal in this way or that way, it affects what if I have a glass of wine before my meal, it's way worse than I have
Starting point is 00:49:28 it with my meal. So you begin to learn about your own biology. And what's really interesting is that it's not uniform. So for example, there's something called the glycemic index or glycemic load, but it really depends on the person, right? If you look at a study, for example, that out of Israel, they looked at the same foods on different people. And depending on their microbiome, their blood sugar levels were quite different. That's just one variable, the microbiome. But there's many other variables, genetic variables, nutritional status variables, and so forth that are going to affect your metabolism. So learning how your body works, getting the continuous glucose monitoring is a super helpful
Starting point is 00:50:03 and personalized way to identify what works for you and what doesn't. So I'm a big fan. Let's talk about supplementation. There are a lot of companies that are out there that are advertising that this supplement is the best thing ever for brain health. What are actual supplements that have a strong evidence base for supporting brain health on top of all the basic lifestyle stuff? And what are ones that are maybe we should be a little bit skeptical or maybe watch out for when it comes to a category?
Starting point is 00:50:33 So they're called supplements, not replacements. And so if you're eating a crappy diet, not exercising under tons of stress, not sleeping, exposed to toxins and your microbiomes are a mess, you know, you're going to not really see huge impact. And you, you, you, you know, you have to really look at addressing the factors that are causing the imbalance that we talked about. And then when you start to put these ingredients in, the body can really respond, right? So the most important one is DHA for the brain, which is docosahexaenoic acid. It's an omega-3 fat, comes from fatty fish, you can get it from algae. That would be my number one. There are really important cascades around B vitamins and detoxification that are important.
Starting point is 00:51:15 These are genes that affect your metabolism of folate, B6 and B12, and also glutathione. So taking B6, B12, and folate, super important for the brain. Magnesium, also really important for the brain. It helps deal with anxiety. It helps to stimulate a receptor called the NMDA in the brain, which calms down the sort of overexcitation that happens in the brain that leads to inflammation, oxidative stress. So B vitamin, fish oil, vitamin D, magnesium, these are staples for the brain. Great. So let's go into some questions from our community. And starting with the first one, what are the top foods for brain health? So you already mentioned a few, but maybe you can expand on this a little bit further and add in some additional ones that
Starting point is 00:52:02 you didn't get a chance to talk about. Sure. So the categories are omega-3 fats, other good fats, and polyphenols. And there's a whole category of other things that can be helpful. So in terms of the omega-3 fats, the fatty fish is really important. We talked about things like olive oil, avocados, nuts and seeds, great for the brain. Walnuts look like a brain. Kind of a brain food. They have good omega-3 fat levels. Also, eggs are really amazing. So eggs have gotten a bad rap. You want to make sure you have pasture-raised eggs
Starting point is 00:52:32 because those yolks have far more nutrients and polyphenols. And the reason they're dark yellow as opposed to this pale yellow that we see in most modern eggs is because of all these plant compounds that give it its power. It also has choline, which is super important for the brain because it's one of the neurotransmitters is acetylcholine, and you need choline to actually help your brain work properly. So it's really great in terms of the brain. So I think eggs are a great brain food.
Starting point is 00:53:01 We also have all the berries. They're great because they have this class of compounds called proanthocyanidins, which are powerful antioxidants, anti-inflammatories. Dark green leafy vegetables, also really important because of things like vitamin D, sorry, vitamin K and folate, lutein, many other compounds that are great for the brain. And of course, turmeric, which is a spice that we've used a lot in Indian cooking, but it's a wonderful, powerful anti-inflammatory that has really been effective for the brain. So those are some of the top ones I think about.
Starting point is 00:53:32 There's some other ones that maybe we're thinking about like green tea, which has a lot of catechins, theanine which is calming for the brain. So there's a lot of benefits from those. Next question from the community. What is the role of CoQ10 in the brain. So there's a lot of benefits from those. Next question from the community. What is the role of CoQ10 in the brain? Well, this is a big rabbit hole. So one of the things that people need to understand is that your brain is one of the biggest consumers of energy in the brain. We've heard the stats that it's 5% of your body weight or something, or maybe less, three pounds. So that's like a fraction of a percent, I guess, but it consumes 25% of the energy in the body because it's very busy. And in each brain
Starting point is 00:54:09 cell, there are tens of thousands of mitochondria, which are the energy factories in your cells that you need to actually run your brain. And if you have low energy in your brain, you have Alzheimer's, you have autism, you have Parkinson's, you have all these things that are really an energy deficit. So the question is, how do you build energy in the brain? It's all that we've talked about so far, but there are certain nutrients that are so critical for reviving and helping the mitochondria function better. CoQ10 is one of them, but there's many more. Carnitine, CoQ10, ribose, N-acetylcysteine, NAD. There's a whole cocktail of mitochondrial supplements, lipoic acid, B vitamins, niacin, riboflavin. They're so critical to making energy. So think of your energy cells as having a production line where they take food and oxygen and they convert
Starting point is 00:55:01 it to energy that your body uses. That production line has a lot of steps, and each step requires nutrients. And if you're deficient in any of those nutrients, you become dysfunctional in terms of making energy, which has all these downstream consequences in terms of not just brain health, but every aspect of your health and aging. So taking a cocktail of mitochondrial supplements is really important. There's a woman named Suzanne Goh, who presented Grand Rounds at Cleveland Clinic, who's a pediatric neurologist trained at Harvard, Oxford, brilliant woman, published in New England Journal, JAMA, all the top journals. And she's done fascinating functional MRI studies looking at imaging of mitochondria in autistic kids. And she found there's a subset of kids who have really poor energy metabolism in their brains. No wonder they can't connect, focus, pay attention,
Starting point is 00:55:47 do anything. So she gives them a cocktail of mitochondrial supplements and these kids get better. That's not to say that all kids with autism get better with mitochondrial supplements. It's those kids who have that particular pathway and deficit, right? Remember I said, just because you know the name of what you got doesn't mean you know what's wrong with you. If you have autism, it just means you have no social skills. You may not be talking. You have repetitive behaviors. There's certain descriptions we give to the behavior, but we're not talking about the cause. So, you know, when you see these studies that are, these are not even quote functional medicine studies. This is mainstream medical journals,
Starting point is 00:56:21 but it's using the principles of functional medicine of how do you create energy, right? So the difference between functional medicine and conventional medicine often is conventional medicine is about stopping, suppressing, inhibiting pathways, right? The anti-drugs, antibiotics, anti-inflammatories, the blockers, the beta blockers, the calcium channel blockers, right? Or we have the inhibitors, the ACE inhibitors. So we inhibit, block, and anti everything as opposed to optimize and enhance function. So functional medicine uses compounds that help the body do what it's supposed to do naturally, which is how do you make energy naturally? Well, you have all these different compounds in your diet and the supplements that you can take that help these pathways.
Starting point is 00:56:58 So when you enhance function, there's really no side effects. It's actually using the natural pathways of the body to optimize your health. What about the role of caffeine in the brain and the body? Good, bad, thoughts? Okay. Okay. So caffeine. Well, yes, caffeine gives alertness, focus, attention, but often you get a crash. So it creates a temporary boost in focus and energy, but then it depletes adenosine in the cells, which depletes energy, and often you'll get a crash after. So depending on your genetics, your ability to metabolize caffeine, how fast you are, how slow you are, it's going to affect you differently. There are in coffee and tea other compounds. So I often say that coffee is sadly the number one source of antioxidants in the American diet because Americans have such a
Starting point is 00:57:46 crappy diet that there's no other antioxidants because 70% or 60% is processed food. That doesn't mean that you should be drinking a lot of coffee for the antioxidants, but it is a source of antioxidants and polyphenols and they may have brain benefits. So same with tea, catechins and other polyphenols and green tea and other teas actually may have beneficial effects on inflammation, oxidative stress, detoxification. So they can be very helpful. But I think over-caffeinating ourselves is probably not a good idea.
Starting point is 00:58:13 So let's recap here. When it comes to improving our brain health and things that we can do today, starting today, like step one, two, and three, what do you want to share with our audience here as we start to wind down today's masterclass? Well, I think the first thing people understand is that they need to learn how their brain works, what makes it thrive, and what damages their brain.
Starting point is 00:58:37 And they need to systematically go through their life and reduce or eliminate the things that damage their brain and add in the things that help their brain. So what are the worst things that damage their brain and add in the things that help their brain. So what are the things, what are the worst things that damage your brain? Sugar and starch, processed food, stress, lack of exercise, lack of sleep. Those things are fixable by anybody without seeing a doctor, right? And then there are things that the brain needs to function. You need a lot of good fats, a lot of omega-3s. You need a diet that's high in polyphenols, these colorful plant compounds. You need a diet that's rich in certain nutrients like magnesium and vitamin D and the B vitamins, so leafy greens
Starting point is 00:59:18 and colorful fruits and vegetables and nuts and seeds. You need to make sure you exercise because that's one of the best things you can do for your brain. Meditate, do yoga, make sure you get eight hours sleep. These are just simple things you can do. And there's a much more, much more depth about how you can even go down the rabbit hole of, you know, balancing your circadian rhythms and light therapy and various kinds of, we call hermetic therapies, which are therapies that give your body a stress, but then it responds by creating a healing response. So it could be hot and cold plunges. It could be certain types of exercise. There's ways of actually stimulating the body to repair and heal. Then there's even more therapies that
Starting point is 00:59:54 people can think about for their brain, whether it's regenerative therapies like ozone, exosomes, hyperbaric oxygen therapy. These are all things that are coming down the pike that can be really helpful in repairing and recovering brains. But for most people, the basics work so well and are really things that you don't need a doctor for. Well, you have an entire two-part series on brain health. I do. It's called Broken Brain 1 and Broken Brain 2. And people can sign up for it and watch it.
Starting point is 01:00:19 It's on your website at drhyman.com. And if you sign up for Dr. Hyman Plus, you get access to that and your longevity docuseries and a ton of other really great stuff, including premium episodes of your podcast. So that's a great recommendation for where people can go next. Mark, this was a fantastic masterclass and a fantastic breakdown of a topic that so many people care about. I'll pass it back to you to conclude us for today's episode. Well, I think we just have to have hope because we're seeing such an epidemic of brain disorders. I mean, the anxiety and depression is just rampant in our society. And a lot of it's driven by our diet. We see a dramatic
Starting point is 01:00:57 increase in neurodegenerative diseases. We see skyrocketing levels of ADHD and autism. And often people think these are fixed. And I just want people to go home thinking that these are solvable problems, that if we understand how our bodies function, if we take out the bad stuff, put in the good stuff, that people can recover from even the most challenging conditions. There are now survivors of Alzheimer's, survivors of autism. I mean, never heard of that before. So I want people to lead with hope and to understand that they need to focus not only on their general health and wellbeing, but to understand how to create a brain healthy lifestyle, which by the way, also fixes everything else. So it's all you have one
Starting point is 01:01:35 diet for your brain and one for your heart and so forth. So everybody who's been listening and joined this masterclass, if you know anybody with brain issues, which pretty much likely, or you have them, be sure you share this with everybody in your families, in your social media. Leave a comment. If you've worked on your brain, you found a way out of brain damage or a broken brain, tell us about it. We'd love to hear. Subscribe wherever you get your podcasts, and we'll see you next week on The Doctor's Pharmacy. Hey, everybody. It's Dr. Hyman. Thanks for tuning into The Doctor's Pharmacy. I hope you're loving this podcast. It's one of my favorite things to do and introducing you all the experts that I know
Starting point is 01:02:11 and I love and that I've learned so much from. And I want to tell you about something else I'm doing, which is called Mark's Picks. It's my weekly newsletter. And in it, I share my favorite stuff from foods to supplements, to to gadgets to tools to enhance your health it's all the cool stuff that i use and that my team uses to optimize and enhance our health and i'd love you to sign up for the weekly newsletter i'll only send it to you once a week on fridays nothing else i promise and all you do is go to dr hyman.com forward slash pics to sign up that's dr hyman.com forward slash pics p-i-c- That's drhyman.com forward slash PICS, P-I-C-K-S, and sign up for the newsletter,
Starting point is 01:02:48 and I'll share with you my favorite stuff that I use to enhance my health and get healthier and better and live younger longer. Hi, everyone. I hope you enjoyed this week's episode. Just a reminder that this podcast is for educational purposes only. This podcast is not a substitute
Starting point is 01:03:04 for professional care by a doctor or other qualified medical professional. This podcast is provided on the understanding that it does not constitute medical or other professional advice or services. If you're looking for help in your journey, seek out a qualified medical practitioner. If you're looking for a functional medicine practitioner,
Starting point is 01:03:21 you can visit ifm.org and search their Find a Practitioner database. It's important that you have someone in your corner who's trained, who's a licensed healthcare practitioner, you can visit ifm.org and search their find a practitioner database. It's important that you have someone in your corner who's trained, who's a licensed healthcare practitioner, and can help you make changes, especially when it comes to your health.

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