The Dr. Hyman Show - Forever Young: Anti-Aging Tips To Look & Feel Younger | Dr. Mark Hyman
Episode Date: July 26, 2024I always say I want to live to be 120 years old, but feeling strong and healthy as I age is even more important to me. In this episode of “The Doctor’s Farmacy,” I delve into the intricate relat...ionship between inflammation and aging, emphasizing the difference between lifespan and health span. I’m breaking down everything you need to know about the gut microbiome, inflammatory triggers, and effective strategies to reduce inflammation. Plus, I’ll share some practical tips on optimizing your diet and supplements to support your body's natural detoxification processes. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman Sign Up for Dr. Hyman’s Weekly Longevity Journal This episode is brought to you by AG1 and Happy Egg. Get your daily serving of vitamins, minerals, adaptogens, and more with AG1. Head to DrinkAG1.com/Hyman and get a year's worth of D3 and five Travel Packs for FREE with your first order. Shopping for better eggs shouldn’t be confusing. Look for the yellow carton at your local grocery store or visit happyegg.com/farmacy to find Happy Egg near you.
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Coming up on this episode of The Doctor's Pharmacy.
This constant exposure to toxic bad stuff
without enough of the immune-supporting
and inflammatory good stuff
throws our whole immune system out of balance,
leading to low-grade systemic inflammation
that accelerates aging.
We call this inflammaging.
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and I'm always looking for tools and strategies to help me get there.
I want to share with you one of the tools that I found and love,
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research studies conducted over 14 years. AG1 has been third-party tested for safety and is trusted
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K2, and five AG1 travel packets with your first purchase at drinkag1.com slash hymen. That's
D-R-I-N-K-A-G-1.com slash hymen. Now, before we jump into today's episode, I'd like to note that
while I wish I could help everyone by my personal practice, there's simply not enough time for me to do this at scale.
And that's why I've been busy building several passion projects to help you better understand, well, you.
If you're looking for data about your biology, check out Function Health for real-time lab insights.
And if you're in need of deepening your knowledge around your health journey, well, check out my membership community, Dr. Hyman Plus. And if you're looking for curated,
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drhyman.com for my website store and a summary of my favorite and thoroughly tested products.
Welcome to Doctors Pharmacy and another edition of Health Bytes. I'm Dr. Mark Hyman.
Now, you probably heard a lot about living longer, about increasing your lifespan, but
what about increasing your healthspan?
That's the quality of life you enjoy during those years.
It's not just about adding years to your life, but life to your years.
Let's face it, who doesn't want to feel young and vibrant for as long as possible?
I certainly do.
Now, some of you might be thinking, aging, eh, that's decades away from me, or eh, chronic
diseases, something older people worry about.
But here's the truth.
The signs of aging and chronic diseases can begin much earlier than most of us expect,
and the foundation you built with your health today sets the stage for how you age tomorrow.
In functional medicine, we view the body not as separate parts, but as a connected whole,
a network of systems where each one impacts the others.
Now, conventional medicine breaks the body into more than 135 specialties.
But here, we focus on the big picture.
It's about systems medicine, about network medicine. Your body is a system or a network. About understanding and optimizing the seven core systems that your body
has that are required to work in harmony so you don't just age well, you can actually reverse
aging. Now, here's a fun fact. I'm going to brag a little bit. In the last few years, I've been
working on my health span because I can't work on my chronological age.
I can work on my biological age.
And I did a number of things to up-level my health based on what I've learned in my research
for Young Forever in my book about longevity.
And I actually got four years younger biologically while I got two years older chronologically.
So that's what we can actually do.
So I demonstrated myself, which
made me very excited, but I want to have you learn how to do it too. And that's what we're
going to talk about today. So many of the steps we're going to discuss today are interconnected.
So what benefits one system tends to benefit all of them. From steering clear of ultra-processed
foods to embracing nutrient-dense whole foods, these strategies are about making smarter choices
that impact
your entire body. Your body is an ecosystem. It's one system. It's not a bunch of different parts
all divided into specialties, all requiring a different doctor for every inch of your body.
It's just ridiculous. You are one integrated organism. And that's what we're going to talk
about today. Unlocking the secrets of functional medicine to help you feel and look younger.
So let's get started. So what's the first system we look at in functional medicine? It's your gut. We call this
the assimilation system. It's assimilating nutrients, it's digestion, it's the gut microbiome,
and our gut is intimately connected to our oral health and longevity. We used to think of the gut
as just an isolated digestive system, a tube from our mouth to our butt that food passed through on its way and we absorbed what nutrients we needed and
got rid of the rest. Well, it's way more than that. Today, we understand that gut's extensive
influence on overall health, inflammation, on aging, chronic disease like cancer, heart disease,
autoimmunity, dementia. Yeah, even dementia is affected by your gut microbiome.
You know, the gut is home to about 30 trillion bacterial cells, about the same number of human
cells, but it houses about 5,000 different bacterial species. And there's about two to
seven million bacterial genes in there, which are way more than your 20,000 genes. So there's
all kinds of stuff going on in there that's affecting your health. Now, this whole ecosystem is called the microbiome.
Now, a balanced gut microbiome supports optimal health, but an imbalanced microbiome causes
disease. And an imbalanced microbiome is called dysbiosis. That's when you got too many weeds
and not enough good guys, right? Dysbiosis is the opposite of symbiosis, right? Where everything works together. This is where things don't work together so good. It's like too many weeds and not enough good guys, right? Dysbiosis is the opposite of symbiosis, right?
Where everything works together.
This is where things don't work together so good.
It's like too many weeds growing in the garden.
And that's what harmful bacteria take over.
And that leads to a weakened gut barrier, also known as a leaky gut, which lets food
and bacterial toxins and food particles leak into your bloodstream, causing an immune reaction.
That leads to something we call
endotoxemia. That's leaking of bad bacterial toxins and other inflammatory things into the
body. And that creates something called systemic inflammation. And that systemic inflammation
drives up the risk of all chronic diseases, heart disease, cancer, diabetes, dementia, you name it, it's driven up by a
leaky gut and inflammation-driving system that also leads to autoimmune diseases, allergies,
asthma, skin issues, all kinds of stuff.
So you feed your garden every day.
With every bite of food, you feed the good bugs or maybe you eat crap and feed the bad
bugs.
And you heal or you harm the gut lining based on what you're eating. You see, bad bacteria thrive
on bad stuff, starches, sugars, ultra-processed foods, and the good bacteria feed on the three P's.
Prebiotic fiber, things like avocados, artichokes, asparagus, green bananas, chia seeds, pistachios,
there's a whole list of them and I've written a lot about this and we'll put more in the show notes.
Probiotics, things like fermented foods, sauerkraut, pickles, tempeh, miso, natto, and kimchi.
Polyphenols, that's the third P. That's colorful plant compounds, things like olive oil, turmeric,
green tea, pomegranate, cranberry. Those are amazing. They feed the good bugs and they love
to eat that stuff. You can also obviously take a probiotic supplement. So those all are really key for your gut. Now, I actually had ulcerative
colitis. I had a horrible gut issue after taking the antibiotic. You might've heard me talking
about this and ended up with C. diff and C. diff colitis and then colitis and C. diff went away,
but I still had colitis and I was a mess. And I developed a product that I actually used to cure
myself, which included all the three Ps, prebiotics, probiotics, and polyphenols. And it's called gut
food. And I've used it for myself and my patients with great success. Now, certain bacteria have
anti-aging effects. They produce postbiotics. Now, what's a postbiotic? A postbiotic is
essentially something that bacteria makes that's then released into the gut or
absorbed in the body that has an influence on your health. And there's a really important one
called butyrate that keeps inflammation low and it also protects against cancer and chronic diseases
and it's basically the fuel for the intestinal lining. Longevity is also, I think, best achieved
from the inside out. It's not putting stuff on your skin and getting facelifts and laser and plastic surgery because that's a losing game.
You want to get healthy and young from the inside out.
And that's really what we do in functional medicine.
So once we fix our gut, meaning the inside, we fix everything else too.
Our skin, our mood, our brain health, cognition, joint pain, and
inflammation. So, tending your inner garden, fixing your gut, learning how to take care of your gut,
what causes it to be messed up, and what caused it to heal is really important. So, that's a core
life skill like anything else, like driving your car, using your iPhone, basically making your bed.
It's just one of those things you have to learn how to do, and it's not that hard. The next system
we have to think about, and these are, by the way, these are seven core
systems in functional medicine. We talked about these biological networks or interrelated systems
that all influence one each other. They're not really separate. They're dynamic and connected.
They're like a web. So like I said, you know, 60% of your immune system is in your gut, right? But
it's your gut. Well, what about your immune system?
Well, it's all connected, right?
So the second system, we just talk about these as separate things in order to just discuss
them and help you differentiate what's going on, but they're not really separate.
The next one is defense and repair.
This is our immune system, our inflammatory system.
And inflammation is important.
Like we want to get inflamed if we have a sore throat or we sprain our ankle so we can bring in white blood cells and heal and repair and all that stuff
is great. But when it's out of control, that's not good. So inflammation is a really important
function of the immune system. It helps protect us against infections, viruses, bacteria,
heal injuries. The problem is that inflammation in our modern lifestyle has gone rampant. We're
overloaded with all sorts of inflammatory triggers,
ultra-processed diets, which is the worst.
They're high in starch, sugar.
Those spike our blood sugar.
They spike insulin levels.
And high insulin levels drive insulin resistance,
and that drives more inflammation.
It's a vicious cycle.
The next thing that drives inflammation is environmental toxins,
things like heavy metals like mercury or lead.
Lots of plastics and petrochemicals, PCBs, phthalates, BPA.
All kinds of PFAS chemicals that are in pretty much everything.
The forever chemicals.
Those are all driving inflammation.
A microbiome that's out of balance is a huge driver of inflammation.
We just discussed that.
So bad gut bugs.
And even stress is an inflammatory trigger.
Now, stress includes physical trauma like accidents or ultraviolet radiation.
It includes electromagnetic frequencies and even psychological trauma, obviously.
And that can really be the result of abuse or neglect.
And that has a physiological effect on your body
that drives inflammation. So we have so many things that cause inflammation and we don't
have enough of the things in our life that protect us against inflammation. So we want to start to
eat an anti-inflammatory whole foods, phytonutrient rich diet. We want optimal levels of vitamins and
minerals, exercise, sleep, relaxation, love, community,
meaning, and purpose. This constant exposure to toxic bad stuff without enough of the immune
supporting and inflammatory good stuff throws our whole immune system out of balance, leading to
low-grade systemic inflammation that accelerates aging. We call this inflamaging. Now this results in
DNA damage, including shortening of the telomeres and cellular damage. And that forms senescent
cells or we call zombie cells, half alive, half dead cells that secrete all these pro-inflammatory
cytokines. And that leads to more inflammation and faster aging of our organs and tissues.
And it shows up as damage to our skin,
wrinkles, it damages our muscles, causing sarcopenia, our joints leading to arthritis
and joint pain, our blood vessel lining called our endothelium, which leads to atherosclerosis or
hardening the arteries or plaque in your arteries, leads to heart attacks, neuroinflammation,
which can cause dementia, Alzheimer's and depression, insulin resistance, which can cause dementia alzheimer's and depression insulin resistance
which lead to diabetes and cancer all this is affected by all these triggers and so we're
kind of in this vicious cycle of inflammation it's accelerating our rate of aging in fact the
whole process of aging is sometimes called called inflammation now here's something that might shock
you i've measured biological
ages and people who are in their 30s and 40s who are biologically a decade or two older inside
their bodies than their chronological age and it's for sure an eye-opener and i mentioned i'm 39
biologically even though i'm 64 chronologically well that's good for me but not for everybody
else who's aging faster so the good news is if you know what to do, you can get a handle on it.
Now, you can get your inflammation level checked by your doctor, or you can put the data in
your own hands using full service testing platform like the one I co-founded called
Function Health.
It's a modern healthcare company that gives you access to the first ever 100 plus lab
test for less than 500 bucks a year with insights from top specialists
and myself obviously and there's no doctor's appointments there's no health insurance needed
just you completely in charge of your own health and the knowledge to help avoid disease and vastly
improve the quality and length of your life now i help build function health to make low-cost
comprehensive testing available to everybody we're very mission oriented with a very long-term
perspective 100 years to be
exact. We want everybody to live 100 healthy years. So you can check it out. We can sign up and
jump the wait list by going to functionhealth.com forward slash mark. Now, what are the strategies
to reduce inflammation? Well, first, get rid of the bad stuff, right? Eliminate sources of chronic
inflammation like ultra-processed food, gluten conventional dairy alcohol refined oils and excessive
snacking all bad for you try to reduce your exposure in environmental toxins
like heavy metals BPA phthalates parabens make sure you don't have any
mold exposure in your house focus on eating good stuff right eat a whole
foods pegan diet I wrote a book about it. Check it out.
We'll put it in the show notes.
But it's basically a joke between paleo and vegan.
But it's just real food.
Whole food, low glycemic food, lots of colorful plant foods for gut and immune support.
Phytochemicals that are great for your immune system like turmeric, ginger, leafy greens,
like the broccoli family, cauliflower, cabbage, bok choy, brussel sprouts,
all those are incredibly helpful and anti-inflammatory detoxifying. Good fats,
right? Olive oil, avocados, nuts and seeds. Omega-3 fats, wild-caught, low-mercury fatty
fish is really important, like sardines, mackerel, anchovies, and herring. Flax seeds are great.
Pasture-aged eggs can be great sources of omega-3s.
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What's the next system? Well, the next system is about biotransformation and elimination,
also known as detoxification. Now, this is a normal process in your body. Now, the term
detox often brings up all sorts of stupid things like fad diets or maybe rehab from alcohol.
But the biological detoxification system that each of us have is sophisticated and it's crucial for removing internal waste and environmental toxins.
Now, what are detox organs?
Well, there are liver, which processes toxins and excretes them through the bile and the
gut.
Our kidneys, which filter waste from the blood and urine.
And lungs, which we breathe out the toxins.
Our skin, which excretes them by a sweat, and our gut, which removes food waste, ingested toxins, and hormone metabolites by the colon.
And also the lymphatic system, which cleans the metabolic waste and the environmental toxins.
Now, the problem is our modern environments are often overloaded.
And our detox systems are overloaded.
We're exposed to toxins everywhere
we go. Heavy metals like lead, mercury, cadmium, pesticides, PCBs, air pollution, food additives.
I mean, the average person who eats an ultra-processed diet has 22 pounds of food
additives a year. Many chronic conditions that make us die young and age faster, including
Parkinson's, for example, are related to environmental toxins. For example, trichloroethylene is commonly used in dry cleaning, degreasing,
decaffeinated coffee. That's linked to increased risk of Parkinson's. So how do you support
your detox system? The first thing is you want to reduce your exposures, right?
So, and the Environmental Working Group has a really wonderful guide on how to reduce exposures from every source, right?
Skincare products, household cleaning products, food, and so forth.
But you also need to learn how to fix your own detox system.
I call it the P4 system or the 4P system, right?
It focuses on enhancing the body's natural detoxification systems. The first step is to enhance your liver function, and that's how it processes toxins.
That's the first P.
So how do you enhance your liver's detoxification system and help its ability to process toxins?
Well, eat a lot more of the cruciferous vegetable family.
They're my go-to.
That's broccoli, cauliflower, kale, cabbage, arugula, collards,
kohlrabi, brussel sprouts. All those foods are rich in something called glucosinolates,
which is a precursor to something called sulforaphane, which is a powerful detoxifying compound and it boosts glutathione. One of the most powerful foods that does this is broccoli
sprouts. And you can get those in some stores. You can make them yourself. The other thing you
can often use is whey protein, particularly goat whey because whey protein does increase glutathione and has
a lot of amino acids that are needed for detoxification. You also need a lot of
nutrients to metabolize your toxins, things like folate, zinc, selenium, magnesium, manganese.
You need all the methylating B vitamins, folate, B12, B6.
And you need, these are all cofactors that basically power all those detox enzymes that
are processing on the toxins. So eating a whole foods diet, taking a multivitamin mineral,
that'll help fill in the nutrient caps and get you most of the way there.
What about protein? Protein's important because one of the major pathways,
well, many of the major pathways, in fact, are reliant on amino acids to properly detoxify, like glycine condensation, gluconidation,
so forth.
And these are basic biochemical steps that require the right amount of amino acids and
protein.
And I encourage people generally who are trying to stay healthy and keep muscle is to eat
0.7 to 1 gram per pound of ideal body weight of protein.
The beautiful thing about protein is it's full of other good things like B vitamins, amino acids,
glycine, taurine, cysteine, methionine, all critical. Methionine is important for making
glutathione. Glutamine also is important for making glutathione as well. So it's really important to make sure you're
taking the right proteins to boost your detoxification pathways.
Okay, what's the next key core system? Well, it's our communication system. This is called
the communication system, but it's a network of messenger molecules in your body. It's your
hormones and your transmitters. It's all your cell signaling molecules or cytokines. And there's all these peptides. Everything is just running
around sending message everywhere. And these messenger molecules, including what I mentioned,
the hormones and our transmitters, peptides, and lots of other cell signaling molecules,
they really are required to help us maintain optimal biological function. Now, when these
messengers are balanced, your health is good. And when they're imbalanced, you get problems with your health, right? Aging typically brings
about hormonal changes that are commonly affecting our hormones, like insulin resistance or
prediabetes, low thyroid function, higher cortisol levels, decreased sex hormones like testosterone
in men and estrogen in progesterone in women,
decreased growth hormone, and even altered neurotransmitters and more cytokines.
So just because it's common doesn't mean it's normal.
Insulin resistance is the biggest hormonal disorder we face.
It probably affects 9 in 10 Americans.
The root cause of inflammation is insulin resistance.
And it's also the root cause of chronic disease,
of sexual dysfunction, of worsened perimenopause and menopause symptoms, hot flashes, mood swings, and too much insulin causes stubborn belly fat. It's just bad. What else can balance your hormones?
Exercise, because it just balances everything. Alcohol definitely messes up hormones and just
drinking alcohol will increase
estrogen levels and it'll also have negative effects on hormones in many, many ways. So you
don't want to be drinking actively and it's not good for your health. It's a recreational drug,
occasionally it's fine, but it's really quite clear that the data does not support alcohol
for any health benefits, just to be clear. Actively managing your stress is important
and not with drugs, but things like adaptogens, rhodiola, ashwagandha, ginseng, Siberian ginseng,
all can be helpful. Theanine is an amino acid that can be helpful. Also sleep, getting your
sleep sorted really helps your hormones. Wake and sleep at the same time every day.
Get morning sunlight. Don't get blue light at night. Maybe if you're
struggling with hormones, you might need bioidentical hormones for men or women.
Now, there's synthetic hormones. There's animal-derived hormones. But those gave
hormone replacement therapy a bad rap due to its link to high risk of heart attacks,
inflammation, stroke, weight gain, and cancer. But bioidentical hormones,
topical bioidentical estradiol, progesterone, even vaginal estradiol, or low dose or topical testosterone, or men can take intramuscular, even oral, they're better tolerated. You want to
basically do the lowest dose possible and for the shortest amount of time possible. But bioidentical
hormones can be an important part of an optimal health regimen.
The next system is optimizing circulation and blood flow.
We call this transportation.
Our body contains about 100,000 miles of blood vessels,
enough to go around the earth about two and a half times.
The lining of the vessels is called the endothelium.
Now, the endothelium makes something called nitric oxide,
which you probably heard about from Biagra because it's what increases blood flow. But it's a gaseous
substance that dilates our blood vessels and keeps the blood flowing. Now, when you don't
have healthy levels of nitric oxide or you have problems with your endothelium,
your arteries get stiff and that can result in high blood pressure. You can have more cholesterol deposits in there, causes oxidative stress, plaque buildup,
clogs our arteries and cause hardening of the arteries.
When our blood vessels get dysfunctional, then our arteries get stiff.
That causes high blood pressure.
Cholesterol gets clogged up in there and you get oxidative stress.
You get plaque buildup.
And this basically causes atherosclerosis and this is the cause of heart disease, right?
This is the number one killer worldwide.
Now, why should you care?
Well, the rate of heart disease in young people, 25 to 44 is increasing.
Now, I've seen 30-year-olds having heart attacks, which is terrifying. Now, becoming way more common, rising by about 2% each year for the last 10 years.
That's kind of scary.
Now, what are the signs of having blood vessel issues?
Well, sexual dysfunction, erectile dysfunction is a big one, insulin resistance, weight gain,
high blood pressure.
All those are clues. There's about 700,000 people who die every year from heart disease.
And half of these cases have no prior symptoms before the event.
In fact, in 50% of the cases of heart disease, the first symptom is sudden death.
So you don't want to be that, right?
So the key is prevention.
You got to know your numbers.
You got to have the right testing.
And you need comprehensive lipid testing, including total cholesterol, triglycerides,
HDL, LDL, and also ApoB, which most people don't get checked, and something called lipoprotein fractionation, which is a measure of how the size is and the number of particles are.
This is a much better indicator of your risk of heart disease. This measures the size, the density, and the number of particles are. This is a much better indicator of your risk of heart disease.
This measures the size, the density, and the number of the LDL particles.
There's another big risk factor that often doesn't get checked called lipoprotein delay,
which is more genetic, but it's important and can be managed.
Now, most cholesterol panels just don't include these.
Now, and they don't give you a full picture.
So you want to get the right tests.
So how do you protect your endothelium?
Well, clean up your diet.
Same as always.
Poor diet is the number one cause of heart disease.
So heart disease and insulin resistance are pretty much two peas in a pod.
People with type 2 diabetes are two to four times more likely to get heart disease or
heart attacks.
So you got to fix the insulin resistance.
And how do you do that?
Well, you know by now, don't eat ultra processed foods.
Don't eat bad fats.
Rancid omegas seed oils, which are bad.
Focus on low-glycemic whole foods, fruits, veggies, healthy fats, fiber, non-starchy veggies,
non-starchy fruit that are like berries, for example, not like a lot of pineapple.
Heart-healthy fats like olive oil, avocados, macadamia nuts, polyphenols, really important, green tea, ginger, turmeric,
oregano, rosemary, all full of antioxidants. Obviously, you don't smoke. Obviously,
learn how to regulate stress, limit your alcohol intake, like max one drink three times a week.
A drink is an ounce of liquor, five ounces of wine, or 10 ounces of beer, but that's really even too much. It should be just
basically the healthiest dose is none. Now, certain supplements may be helpful with
people with insulin resistance, and I use them in my practice like lipoic acid, magnesium, chromium,
berberine, vitamin D, omega-3 is all really helpful. We'll put all this in the show notes,
so don't worry. Now, these seven biological systems are basically descriptions of how your body works.
It's not perfect.
Obviously, it will be modified and improved as we begin to understand things more.
But these basic systems are all a network.
They're all connected.
They're all dynamically influenced one another.
So you have to understand all of them and work to optimize all of them by taking out the bad stuff, putting in the good stuff. And that's essentially what functional medicine is all about.
So I really appreciate your tuning into this episode. Remember the journey today to feeling
younger and looking younger starts with understanding and nurturing how your body
is one integrated ecosystem. There's just so much we can do without a doctor to optimize our environment and our diet
and our lifestyle to improve our gene expression and to slow and even reverse biological aging
now what we talked about today if you do those things you're on your way to a healthier more
vibrant life thanks again for joining me today and i'll see you next friday for another juicy
episode of health Bites.
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This podcast is separate from my clinical practice at the Altra Wellness Center and my work at
Cleveland Clinic and Function Health, where I'm the Chief Medical Officer. This podcast represents
my opinions and my guests' opinions, and neither myself nor the podcast endorses the views or statements of
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