The Dr. Hyman Show - How Peptides Enhance Healing and Longevity | Dr. Edwin Lee

Episode Date: June 26, 2024

View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman Sign Up for Dr. Hyman’s Weekly Longevity Journal Peptides are gaining popularity for their remarkable health benefits, bu...t what exactly are they and how can they help you? In this episode of “The Doctor’s Farmacy,” I sit down with Dr. Edwin Lee to demystify the incredible world of peptides. We delve into how these tiny proteins can regulate every function in your body, from hormone imbalance to tissue repair, and even cognitive health.  In this episode, we discuss: The crucial role peptides play in regulating our wellbeing BPC 157, a peptide that shows promise in accelerating healing from injuries and reducing inflammation Epi-thalon, a peptide with potential to improve sleep quality and reverse some aging markers The future potential of peptides, including ongoing research and clinical trials, to unlock further therapeutic uses and improve patient outcomes The importance of using peptides under proper medical guidance to ensure safety and efficacy Learn how peptides can optimize your overall health and longevity, and why they might just be the future of medicine. This episode is brought to you by Rupa University, Cozy Earth, LMNT, and Cymbiotika. Rupa University is hosting FREE classes and bootcamps for healthcare providers who want to learn more about Functional Medicine testing. Sign up at RupaUniversity.com. Right now, you can save 30% when you upgrade to Cozy Earth sheets. Just head over to CozyEarth.com and use code DRHYMAN. LMNT is giving listeners a FREE eight-count sample pack of their vital electrolyte drink mix with any purchase. Just visit DrinkLMNT.com/Hyman today. Upgrade your supplement routine with Cymbiotika. Get 20% off with free shipping on all orders. Head to Cymbiotika.com and use code HYMAN.

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Starting point is 00:00:00 Coming up on this episode of The Doctor's Pharmacy. In my neighborhood, all my neighbors ring my doorbell and they have some type of injury. So they just point to where they need a peptide injected. So they point to their shoulder or to the elbow, their foot, their ankles. So I have every day someone's ringing my doorbell to get a peptide shot. If you're a healthcare practitioner like I am, you know how hard it is to keep your medical knowledge up to date, especially when it comes to functional and specialty lab testing. You could spend a ton of time waiting through the latest medical literature, but that can be hard to fit into an already busy schedule.
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Starting point is 00:01:42 Remember, go to CozyEarth.com slash Dr. Hyman, D-R-H-Y-M-A-N, to enjoy 30% off using the code Dr. Hyman. That's D-R-H-Y-M-A-N. And after placing your order, please select podcast in the survey and then select the doctor's pharmacy in the drop-down menu that follows. That's C-O-Z-Y-E-A-R-T-H.com slash D-R-H-Y-M-A-N with the code Dr. Hyman, D-R-H-Y-m-a-n with the code drhyman, d-r-h-y-m-a-n at checkout. Are you ready to prioritize wellness? Maybe you want to make more informed choices on the latest
Starting point is 00:02:13 health trends or simply understand the science. I'm Dr. Mark Hyman. I'm a wellness expert and I want to welcome you to my podcast, Health Hacks. In every episode, I'll provide guidance on how to live a longer, healthier life, helping you wade through all episode, I'll provide guidance on how to live a longer, healthier life, helping you wade through all the health ads and the soundbites to bring you the science-backed facts, along with practical tools and insights to make informed decisions. Health Hacks is available in audio and video, so you can tune in wherever and however you enjoy your podcasts. Join me every Tuesday for a new episode. Just search for Health Hacks, where my goal is to empower you to live well. Now, before we jump into today's
Starting point is 00:02:50 episode, I'd like to note that while I wish I could help everyone by my personal practice, there's simply not enough time for me to do this at scale. And that's why I've been busy building several passion projects to help you better understand, well, you. If you're looking for data about your biology, check out Function Health for real-time lab insights. And if you're in need of deepening your knowledge around your health journey, well, check out my membership community, Dr. Hyman Plus. And if you're looking for curated, trusted supplements and health products for your health journey, visit my website, drhyman.com, for my website store and a summary of my favorite and thoroughly tested products. Welcome to the doctor's pharmacy. I'm Dr. Mark Hyman. That's pharmacy when they have
Starting point is 00:03:31 a place for conversations that matter. And today's podcast is on a topic you may or may not have heard about, peptides. Although you probably have heard about it if you've ever heard about insulin or the more recent peptide of note, Ozempic. Now, peptides are in our bodies all over the place, thousands and thousands of them, and most of us probably don't know what they are or how they work, but they're critical in our health. And Dr. Edwin Lee, our guest today, is an expert. He's an endocrinologist, he's an author,
Starting point is 00:03:55 and he's founded the Institute for Hormonal Balance in Orlando, Florida. He's a board-certified physician in internal medicine, endocrinology, diabetes, and metabolism, and has specialized training in regenerative and functional medicine. He's a graduate of the Medical College of Pennsylvania and finished his two fellowships, critical care and endocrinology, at the University of Pittsburgh, and is the author of many books, and the latest one is called The Fountain of Youth
Starting point is 00:04:16 with Peptides. He's the lead investigator for an IRB-approved senolytic study investigating the role of peptides as well in our health health and the trial using BP-157, an important peptide for joint and bone and muscle repair injected for knee pain. And he also works as an assistant professor at the University of Central Florida College of Medicine. And he's the co-founder of the Clinical Peptide Society. So Dr. Lee and I dive deep in this topic,
Starting point is 00:04:41 which you may think is a bit esoteric, but I encourage you to stay with me because peptides are the future of understanding how to regulate our biology using bioidentical molecules. Now, Zempik you've seen is the latest one, but there's lots more. We're going to talk about some of the most important ones. There's 7,000, maybe more. There's ones like thymus alpha-1, BP-157.
Starting point is 00:04:59 We talk about what they do in the body, how safe they are, why the FDA is cracking down on them, and how they are, why the FDA is cracking down on them, and how they can delay aging and reduce inflammation. I personally use peptides with great advantage, and I encourage you to tune into this really enlightening conversation with Dr. Edwin Lee. So Edwin, it's great to be here with you. We're at the Integrative Healthcare Symposium Live, and we're recording this podcast about a topic that I think has sort of captured a lot of people's imagination,
Starting point is 00:05:25 particularly longevity, biohacking space, which is peptides. And I don't know if the average person even knows what a peptide is, but we're going to get into what they are, but they're highly prevalent in the body. They're things your body makes to regulate almost everything that's going on. They're little mini mini proteins essentially that um are the communication network of your body and they regulate every single function from your hormones to your brain function to your immune system your sexual function to tissue repair i mean it's quite amazing that we've kind of you know gone this long in medicine without really taking a hard look at peptides in a conventional way. Now, there are things that people know of as peptides
Starting point is 00:06:11 that you don't even know are peptides, right? Like insulin is a peptide. Ozempic is now the sort of blockbuster drug of the day. And that's a peptide. That's a peptide. Glutathione is a peptide. Glutathione is a peptide, yeah. So there's a lot of compounds that we use in medicine that are peptides uh there's probably over 7 000 produced
Starting point is 00:06:30 by the body right um actually technically 300 000 300 000 okay i was off by a few thousand but we only understand a fraction of it and uh outside in nature uh there's uh i think i estimate about six million peptides out there. That's incredible. 6 million. I mean, a lot from venoms and from animals. Not in human peptides, but other peptides. Oh, yeah.
Starting point is 00:06:54 Dairy. There's really amazing spiders and just interesting creatures. Nature has a lot of wealth. As a functional medicine doctor and interested in regenerative medicine, I really love the idea of using bioidentical molecules to support the body to do what it's supposed to do. Oh, definitely. Yeah. So the drug is essentially a new-to-nature molecule that interferes or interrupts or blocks some pathway in the body. And there's usually downstream side effects.
Starting point is 00:07:25 Okay. Hepatitis also can have side effects when used in pharmacological doses, like we're seeing with Ozempic. But these are biomolecules that have, we've evolved over, you know, millennia that regulate everything that's happening in our body. So they're getting a lot of kind of play in the sort of longevity space to optimize cognitive health,
Starting point is 00:07:43 to rejuvenate your skin, to help with tissue repair, to improve sexuality, vitality, longevity. So kind of take us from the top down. What are peptides? How do they work in the body? And how can they be used to treat disease, optimize health, and rejuvenate our biology? You did a great explanation of peptides, but the way I explain to my patients, Mark, is that peptides are signaling molecules. They're miniature proteins, small little proteins that are made of amino acids. And unfortunately, the FDA has this arbitrary, just made a clarification that under 40 amino acids is considered a peptide, over 40 is a biologic, and then over 100 amino acids traditionally has been considered a protein. So it's the length of basically how many amino acids are put together. And like I said, the body makes 300,000 peptides, we only understand
Starting point is 00:08:40 a fraction of it. And anyway, it really fun to to read the research that's out there um and uh i i just i explained that peptides to my patient is a signaling molecule it's short acting and it's like a doorbell ringing someone ringing your doorbell that's a peptide and some reaction is going to happen either your dog's going to bark or someone's going to answer the door. So if you give a peptide to basically help your immune system, like thymus and alpha-1, that's going to stimulate your immune system work better. So that's a natural peptide produced by your thymus gland. And as you know, Mark, it's thyroid and thymus. Patients always get confused, but it sits in your chest and between your lungs in front of your heart.
Starting point is 00:09:29 And I have some... Sweetbreads, if you like veal, sweetbreads. When you go to a restaurant and you chance your restaurant, they have great sweetbreads. That's what it is, your thymus gland. I didn't know that. You didn't know that? I should order some sweetbread. I wonder if eating it is actually good.
Starting point is 00:09:43 I mean, if you get any TA1 or peptides from eating it after it's cooked, I don't know. Well, they did a study, you probably read, that basically they gave human growth hormone and metformin DHEA and the thymus improved. It was only in men, so they were going to do another trial. I'm curious if it's women. But anyway, if the thymus gets healthier, your immune system gets healthier. So that's one key component, have a healthy immune system. So how do they actually work? Are they like binding to receptors and activating gene expression and regulating various kind of protein networks in the body? Some peptides are so small, like epithelium, it can actually slip through and go
Starting point is 00:10:26 through the nucleus and interact with the DNA through the histone binding sites. And it's, some of these peptides were discovered by Dr. Kamisen who is from St. Petersburg, Russia. He has probably like 40 years of research on these wonderful peptides. And unfortunately, he just passed away a couple weeks ago. So I'm really sad about that. I have so many questions to ask. And you didn't get to ask him. And I did have the privilege to talk to him once. But anyway, to me, he's like one of the top scientists.
Starting point is 00:10:58 And he should have got the Nobel Prize in medicine. Yeah, it's quite amazing. But it also acts in certain receptors. So there's a group of receptor called the G-protein couple receptor. And most peptides interact with that receptor and basically cause a cascade event. And then basically it's like doorbell ringing and then you get a cascade event. Well, it's like insulin. Insulin binds to receptors, the cell, and then kind get a cascade event. Well it's like insulin. Insulin binds to receptors
Starting point is 00:11:29 cell and then kind of opens the gate for the glucose to go in the cell and PLP1 agonists do a similar thing like ozempic. Yeah there is a receptor yes so exactly so it's a general class called the G protein couple receptors. There's one the Nobel Prize in medicine, the G protein couple. Yeah, yeah. Incredible. So there are about 150 peptides now out of the 300,000 that you said that are being researched for medical applications, right? And there's over 80 peptides that are already approved by the FDA for medical use. What are the kinds of things that people should be aware of that peptides work well for, or maybe even better than traditional therapies? Well, in my neighborhood, all my neighbors ring my doorbell and they have some type of injury. So they just point to where they need a peptide injected. So they point to their shoulder or to the elbow, their foot,
Starting point is 00:12:23 their ankles. So I have every day someone's bringing my door to get a peptide shot but I usually give BPC 157 which is one of my favorite peptides it comes from her stomach stomach fluid and actually the history is kind of interesting about that peptide it's I really anyway I can go into that, but it was recently discovered like in 1990s in Croatia. And anyway, I actually published the first human clinical trial in peptides, a lot of research in animals, but I'm conducting two more human clinical trials, which is really exciting. That's amazing. So, BP-157, for example, is a peptide that the body produces.
Starting point is 00:13:11 I'm assuming it's made synthetically in the lab by pulling together the sequence of amino acids. They know the sequence of it. So, they sequence amino acids and they put together that string of amino acids. So, it's synthetically made, but it's a bioidentical molecule. So it's like making testosterone in the lab or making various molecules. Exactly. And then BP-157, let's just sort of unpack that because that's a very popular one. I personally used it.
Starting point is 00:13:37 I've had a bicep tendonitis. I was doing some strength training and it kind of got irritated. And I'm like, well, I'm just going to shoot some BP-157 in there. I did a couple of shots and it went away. And it was, it was impressive. And I've used it for other things as well and found them really very effective for immune function. You know, for when I have COVID, I, for example, use TA1 as a peptide using my patients. BP-157, let's sort of just unpack that for a minute. How does that work in the body when you inject it, for example, systemically in your subcutaneous fat in your abdomen, or if you have an issue with a particular muscle?
Starting point is 00:14:16 Tendon tear. When you have a tendon tear, you inject it into that. What's actually happening? Well, for tendon tear, muscle tear or even like like I inject in patients joints and they have a tear what it's interesting is that the one classic study that was done is they had these rats and they cut the Achilles that sounds fun so poor rat and And basically one group basically got BPC injected in their stomach and the other group just got placebo. And the group that got injected into their stomach, in a month later, they were walking again. And you don't see that in nature. When you have an Achilles repair, it's just going to be further.
Starting point is 00:15:01 This was the first thing that was shown. And that was like, wow. So for my son, he had, basically he was in high school, it was a cross-country team. He had a six-pack. He was just
Starting point is 00:15:12 like born to run. He's developed basically an ITB injury, a little too little, a band. And he couldn't even walk.
Starting point is 00:15:21 ITB, I recall it, right? Yeah. So he just could not even get in and out of the car. And I told him, he was in ninth grade. I said, son, I can inject BPC into your leg. And he said, you aren't effing doing that.
Starting point is 00:15:35 So I had to show him some slides. And I showed him the rat. I had to show him hard data. And he goes, OK, you can inject. And then literally, he was, I don't know, 15 at that time. He quickly recovered. And like a week later, he's running again. That's amazing. It's amazing. And so it actually helps. There's multiple theories on how it could help. But number one, it reduces inflammation. It recruits your immune system to basically heal. But the one part is there's a receptor called the fat-clin C receptor that activates your growth
Starting point is 00:16:12 hormone receptor. So it's a pathway to help growth hormone receptors to be activated so that whatever growth hormone you have, you can actually heal faster. So growth hormone is really involved in healing and repair. Exactly. It's an antibiotic hormone, but you need the receptors and that's what BPC-157 does. And there was a study that once they stopped it, three days later, they still had high expression receptors. So if you use growth hormone peptides with basically BPC and TB4, you will heal much faster. So I have people, I have so many patients who've had all these massive injuries. It's like the testamoylin, samoylin peptides, you mean? Yeah, CJC, 1295, testamoylin, yes.
Starting point is 00:16:53 They can all help heal faster too. Amazing. So it works by helping, for example, growth hormone. There may be mechanisms actually we don't really understand yet. Exactly. What you said in the rat was interesting is they just injected into the abdominal fat. Right. It's a signaling molecule.
Starting point is 00:17:07 So it basically tells the body to... But it didn't have to inject into the Achilles tendon. They did not inject even near the tendon. Does it work better if you inject it near the site? Yes, it always does work better. But that study was truly mind-blowing. In the belly of the rat and the Achilles tendon. That's quite amazing.
Starting point is 00:17:24 And in some ways, peptides are used to treat, you know, injury or illness, right? Like, for example, BP-157 or insulin. Ozempic, you could say, would be something that would be a semaglutide peptide that would be used to treat obesity or diabetes or to help with various things that it helps with. But many of the peptides are not really treating disease so much as bioregulators that regulate our bodily functions to optimize them. Right. And my favorite one in regards to bioregulators is epithalon. Yeah.
Starting point is 00:18:05 E-P-I-T-H-A-L-O-N. And that was discovered by Dr. Cavinson. And so, for example... It's a four amino acid peptide. Four amino acids. It seems like, what would it do? It comes naturally from our pineal gland. Yeah.
Starting point is 00:18:15 And as we get older, like our thymus gland, it will calcify and will shrivel up. And you lose melatonin and you lose epithalon from the pineal gland. Ah. And when you lose epithalon, what happens is your cells that are supposed to self-replicate get stuck in G2. So there's self-replication. So if you want a new skin cell, your body basically can get rid of the old skin cell and then you generate new skin cells. Inside our body, we can generate new heart cells, new myocytes, new liver cells, new pancreas. But our ability gets less. Yeah, exactly, because we're losing epithelium.
Starting point is 00:18:50 And epithelium basically turns on cell cycle. It's the peptide to make you younger. And I have patients who have prediabetes or type 2 diabetes. Some of them have reduction in their medication or even get off their insulin i have patients who basically their macular degeneration is improving their vision is getting better so it's actually making you younger but you can't self-replicate forever because then you have discovered immortality which i haven't discovered yet but anyway far from it i don't think i'll ever do it but i'll ever find it but anyway i, I have patients that hurry up, Dr. Lee, but epitalin is just amazing.
Starting point is 00:19:31 I just love it. Is this something you take every day? Is this something you take a cycle? No, like that Cavison wants you to cycle it. And so I have my patients, which is sad because the FDA has this on the chopping blocks there too, in terms of banning peptides. But you can get epipalent spray, which is actually... Nasal spray.
Starting point is 00:19:53 No, under the tongue. Under the tongue. Normally you have to inject the peptide. The problem is that there's so many on the internet, but if you can get from Russia, the original one, capicin, I'm sure there's not a lot of commerce going back and forth with Russia. Through China. Through China.
Starting point is 00:20:07 Yeah. The black market for peptides. Well, this one's a spray, and this one I trust, Dr. Cavisent. Yeah. So these are... I don't trust the other ones. It's Cavisent's brand. So you mentioned, for example, it's sort of epithelium as a bioregulator that controls our self-replication,
Starting point is 00:20:28 healing, repair. And so they're not like treating a disease, right? Exactly. So you get it. So what happens is... Insulin can treat type 1 diabetes, and that's great. But not all peptides are doing that. In fact, most of them are not.
Starting point is 00:20:39 They're actually simply just enhancing function. Like PT-141, for example. Both thoughts at the same peptide, same time. Yeah. For better libido, better sex drive, better motor. It's actually approved for women. Yes. It has been FDA approved for that.
Starting point is 00:20:57 And it also works for men. Yes. I have a lot of men and women on it. So it increases desire. So does oxytocin. Oxytocin is actually FDA approved. Is it peptide? It's a peptide.
Starting point is 00:21:09 It's FDA approved. Yeah. So oxytocin is the love molecule. It's the breast when you have your sex or when you are breastfeeding. But there's a lot of other benefits. And my nurse practitioner, Becky Murray, is going to do a webinar, I hope it's a monthly webinar. Not as popular as yours.
Starting point is 00:21:26 You probably have thousands. I have only 30 people following. But anyway. One day I'll be as popular as you, Mark. Well, let's see. That's good. There's no way. You're like New York Times bestseller.
Starting point is 00:21:38 That's all right. Someone bought my books. I bought your books. Actually, you know what? I went on Kindle and it was free because I think it's part of the Kindle Unlimited. Oh, really? Yeah. Oh, I'm going to take it off Amazon.
Starting point is 00:21:50 I was going to buy it. I was like, wow, Kindle Unlimited. This is great. This is great. I got no more. Maybe 10 cents a year from Amazon. Let me ask you a question. What do you reach for after you finish a workout? Let me ask you a question.
Starting point is 00:22:07 What do you reach for after you finish a workout? If you're like most people, you probably reach for a sports drink to replenish the water and electrolytes you lost. And that's great, except that most of these drinks are also filled with sugar, food coloring, and other junk. When I want to get the benefits of a sports drink without all the nasty stuff, I reach for Element. Their tasty drink mix has everything I need to give myself a science-backed the nasty stuff I reach for Element. Their tasty drink mix has everything I need to give myself a science-backed electrolyte boost whenever I need it. And there's no sugar, coloring, artificial ingredients, gluten, or fillers, which means it aligns perfectly with my dietary choices. Element is one of the most important tools in my health and fitness toolkit, and I know it can be for you too. Right now, Element is offering my
Starting point is 00:22:44 listeners a free sample pack with any purchase. That's eight single serving packets free with any Element order. This is a great way to try all eight flavors or share Element with a friend. Get yours at drinkelement.com slash hymen today. That's l-m-n-t dot com slash hymen. Getting the right nutrients and minerals is essential if we want to function and feel our best. But most people aren't getting the minimum amounts their bodies need, and with so many supplements out there, finding the right ones can be overwhelming. That's why I love Symbiotica. Their cutting-edge formulas use liposomal technology, making them the most bioavailable and optimal for absorption. Now, if you're unfamiliar, liposomes are fatty membranes,
Starting point is 00:23:22 like little bubbles, that encapsulate nutrients and prevent them from being broken down in your digestive system, increasing their bioavailability or the percentage of the active ingredient actually absorbed into your body. Not only do they formulate their supplements for higher absorption, but Symbiotica is also extremely transparent about how and where they source their ingredients. So you know you're getting high-quality products that are safe and effective without any seed oils, preservatives, toxins, or artificial additives. This also means they taste great without the chalky chemical aftertaste. I like their liposomal vitamin C, which tastes like fresh orange juice, and their liposomal glutathione, which I actually had this morning, which actually tasted yummy, which is
Starting point is 00:23:57 not easy for glutathione. It's the mother of all antioxidants. Plus, they come in convenient little packets, so I never have to worry about missing a dose or packing big bottles when I'm traveling. Right now, you can try them for 20% off with free shipping on all orders. Just go to Symbiotica.com slash Hyman and use the code Hyman. That's Symbiotica, C-Y-M-B-I-O-T-I-K-A.com forward slash Hyman and use the code Hyman for 20% off plus free shipping. So let's kind of dive in a little deeper around some of the use cases and where you're finding the top value for peptides in clinical practice and for patients.
Starting point is 00:24:38 What are the ones you like to use? What do they use for? Okay, number one that I just truly love is if you want skin ghk copper dr pickard discovered ghk and it's a natural uh byproduct so when you have collagen and basically breaks down part of it is ghk so ghk can turn on your fibroblasts to make work basically collagen and hyaluronic acid yeah the skin look better yeah um and you don't have to inject in your face you can just put in your abdomen well we have ghk copper topical topical yeah so i'm not that smart not that good looking
Starting point is 00:25:16 i'm not not a great athlete but i have good skin even though i don't i live in florida and i don't even use sunscreen but uh i use tons of ghk copper on your face Oh, yeah, topical. I love it. Yeah, and I tell all my dad's things like how he inject it Well, no, no, I'm talking about topical but you can't inject and for my father who has passed away recently with very aggressive cancer T cell lymphoma small bowel He had a great life and he basically was told, we really have like 30 days to live, chemo radiation won't work. And I said, all right, dad, you're like
Starting point is 00:25:54 basically in a walker, let me give you some peptides. And so, I mean, for cancer, I mean, there's several different peptides that have a lot of clinical studies. So thymus alpha-1 could help. To help your immune system fight cancer. Oh yeah, yeah, yeah. As an adjuvant. Not a cure. We're not saying it's a cure. What you're saying is... Oh yeah, yeah. All the studies, even stage four, most of them shows basically improvement of longevity, the regression of mortality. So thymus alpha-1 has been used. You can use basically metenkephalin, which I was using. GHK copper turns off also cancer genes. Epithelin can also do that. So, I told my dad, you're going to get some peptides,
Starting point is 00:26:42 and I already drew it up. And my dad goes, I don't want them. He's like, go start. He goes, I don't want them. And he goes, I said, it's too late, Dad. Mom is going to inject you anyway. So you can say whatever you want. And we got eight great months with my dad. That's amazing.
Starting point is 00:26:58 So he went from literally from a walker to walking two miles a day, regained his weight. That's incredible. Yeah, all through peptides. And better nutrition, too. Yeah, amazing. So kind of going down again into the rabbit hole of what are the best use cases?
Starting point is 00:27:16 What are the top peptides in your toolkit? For example, I know my best supplements are magnesium, vitamin D, fish oil. Those are my go-to, right? Probiotic. I would say number one is I love BPC-157. You can take it orally. People with reflux, it tightens the LES junction.
Starting point is 00:27:38 I have some people get off their reflux medicine. That's the bottom of your esophagus where the kind of reflux happens and comes back up from the stomach. And there's not many things that tighten LES junction. Yeah, that's the lower esophageal sphincter. It's like a sphincter at the bottom of your esophagus and that's loose. As it comes up, you get reflux, GERD and all that. That's impressive. But BPC has, FYI, I have people taking it and I inject peptides in their elbow and a month later they re-injure their elbow, but they go, I've been taking that PPC, my shoulder, I can sleep much better.
Starting point is 00:28:12 So it can improve your entire body. So I call it the Wolverine peptide. So you'll get younger. Ah, the Wolverine, so you can grow back. Yeah. So you can stay Wolverine peptide. That's great. So BB157, that's the top of your list. Yeah, so you can grow back. Yeah, so you can stay Wolverine peptide. That's great. Some people never watch Marvel.
Starting point is 00:28:26 That's the top of your list. So we talked a bit about that. And it's great for injuries, for trauma, for tissue repair. Exactly. And I think it's one of the ones that I tend to rely on because I think it really, personally, it's helped me and I think it helps a lot of patients. What other peptides are there? I love thymosin alpha-1 because as we get older, our thymus gland shrivels up and we're trying to basically help the thymus gland, I mean your immune system get healthier. And as you know, Mark, you know, you got to have a healthy immune system because once it goes down,
Starting point is 00:28:56 it goes to two ways. It goes to cancer or to infection. Yeah, we get immunosenescence, which means the aging of our immune system, which is why when you're older, you get more infections. You can't fight them as well. You die of pneumonia. You don't respond as well to the vaccines. And you get, you know, looking at COVID, the people who are elderly had the higher risk of death. And so I think you're, you're talking about a very important phenomenon that we don't really have a good treatment for with traditional medicine. So generally I tell my patients to use like uh 250 micrograms um of uh thymus alpha one like once or twice a week just as just not daily you can use daily if you're sick
Starting point is 00:29:34 like higher doses like you know if you have a better yeah my wife one day she goes she when she gets sick it's like it's a nightmare because I don't know when to drop the kids off. Do I give them lunch money? Where do I pick them up? You don't have a playbook for it. I just, this is the Uber driver. So yeah, I don't, I mean, so when my kids were younger, my wife goes, I took everything, the C, the D, the zinc,
Starting point is 00:29:59 you know, silver. I'm coming down with something. And I said, she goes, you have something else? And I go, yeah, yeah, in the fridge. I have the thymus alpha-1. So I gave her, I remember this clearly, way before COVID, probably 2016 or something like that. So I gave her about one milligram of thymus alpha-1. Next morning, she was perfect.
Starting point is 00:30:20 It's like, thank God, because if she was sick, I wouldn't know how to handle the kids. I mean, we don't have the cure for the common cold. But if you take this, if you start to feel sick, mean when you get that feeling i think i'm getting sick and you pick it it can be profoundly effective oh exactly exactly yeah what what else besides a t1 and bp157 i love epithelium uh then generally we do five milligrams uh sub-q daily for like 10 days if you skip a day or like the weekend you forget that's okay just just make sure you finish the vial so one vial will have fifty five zero milligrams of epithalon twice a year so you do it twice a year yeah like ten days twice a year it's kind of a reset for your longevity and I have people like for me when I was doing it it's amazing my sleep I was on melatonin
Starting point is 00:31:04 every year higher and higher higher doses and do you know epithelin turns on three genes of your pineal gland to make melatonin and my wife goes how come you don't take your melatonin one so I don't need it I could sleep without it so it can reset your pineal gland and help you sleep better so I love that big island because as we get older and you you mentioned the Russian version via the nasal script, but you can also take it... Not nasal, it's under the tongue. Under the tongue, but you can also do it through... Injection through our 503A compound pharmacy, a prescription.
Starting point is 00:31:36 Yeah, amazing. And the... The problem is that most people, when they hear this, they're going to get addicted to epithelium. Do not use it every day for the rest of your life because you're going to stop the magic in terms of self-application. It will eventually, like the Hayflick theory, it's going to stop in terms of it's no longer going to work. Just because a little bit's good doesn't mean a lot's better. Exactly. So, yeah, just be patient and don't take it every day of the year because it's going to eventually stop working. Now, you know, the other thing that sort of happens as we get older is we end up with hormonal changes.
Starting point is 00:32:14 You know, lower testosterone. We have, you know, lower growth hormone. We tend to lose muscle. We sort of age as a result of changes in our hormonal environment. And what's interesting, a lot of these peptides can be involved in regulating hormone function. Well, yes, there are, like, in regards to women that are done with, they're in post-menopause or finished with menstrual cycle, sometimes I tell them, like, you may start your period coming back. And if you get pregnant, please mention me because I want to be famous.
Starting point is 00:32:47 I'm not sure. Acquired, because I can't be famous like you, so I have to go the other route. So anyway, yeah, it's amazing. They go, my period was gone five years ago, and I was coming back. So I don't know how long it's going to keep on going. But they've, in the animal studies. Using which peptide? Epithelium. Epithelium. Yeah. So, ovarian function gets better.
Starting point is 00:33:08 So, it works not just on the pineal gland, but also... Other organs. Maybe the hypothalamus. It can help the heart. Because it turns on gene expression, which is interesting. There's certain proteins that get kicked off, and things work. So, epithelium is, to me that's a good one i love it maybe people are using other ones like uh kiss of pepton which is for testosterone yes kiss pepton 10 it's uh may work like an adrenaline to help with testosterone function but uh um you know those are peptides um that may or may not work in men. It's confusing because the data was IV, and they would do it like 24 hours per body weight,
Starting point is 00:33:51 and it's hard to convert that to how much do you do it sub-Q. So anyway, I have some guys with some better testosterone level with using cospeptin. Then there's the whole growth hormone category of supportive peptides like tesamorelin, samorelin, CJC, Fylde95. Can you talk about those and what role they have and what they do? Yeah, there's really interesting in terms of growth hormone peptides. So I just want to start off with out of all the side effects of all the peptides, that class has the most common side effects. Interesting. So it may affect about 20% of patients and they can't take it anymore. They really get welts in their injection sites.
Starting point is 00:34:43 And then some people really get really bad rashes and it's this entire body so um i i warn them that you know if you see a welt just growing we're going to stop you're you're developing antibodies to it and you're you're not going to be even if you stop and retake it like like six months later it's going to happen yeah again so yeah your body doesn't like it now everyone everyone, I have some people for five, six years and no reactions and doing well. So they're all very slightly, they're very similar, but there's two receptors in the pituitary gland. There's a ghrelin receptor and then there's basically the growth hormone receptor. So these peptides can interact to either one. And like you would do CJC with 1295,
Starting point is 00:35:30 which is part of the growth hormone. It's like part of the active part of the growth hormone that activates the pituitary gland at the growth hormone receptor. And then hypermoralin basically interacts with the ghrelin receptor. So in combination, you have a higher level of basically growth hormone release. And what are the consequences of having that higher level of growth hormone release? Well, this is the controversy about growth hormone. Does growth hormone make you younger or older? And the literature is all over the place.. I am doing a study on that, which is, because I could show you literature on both sides of the, but generally growth hormones consider the founder of youth. But if you overuse it, I think it's bad. It accelerates.
Starting point is 00:36:18 I agree. Yeah. So I think in little use and not bodybuilding use, I think you'll do fine. So, so these, these compounds, you know, you sort of hinted at a little bit, but they are powerful biomolecules, like ozempic, for example, or semaglutide. We're finding that in the doses that it's being given for weight loss and for diabetes, at two years plus, we're seeing significant side effects, like increasing bowel wall thickness, small bowel obstruction, pancreatitis, and other things. And so these are not completely risk-free compounds. So how do you navigate the issue around safety? You think, oh, they're natural compounds. It's safe. I can take them. And people are playing with them. Yeah. So let's use the
Starting point is 00:37:01 semaglutide or ozempic or one journal which is appetite which is and there are others that's the bound to just got FDA approval for This is appetite for weight loss there. So just but the thing is that I'm was kind of the king of the GLP-1 way before the movie started. I wish I had got the hashtag SkinnyPen. But anyway, I don't even do social media, so I don't even, you know, I'm not on Facebook. So were you recommending semaglutide to your patients before, or was that the big deal?
Starting point is 00:37:38 Refuse. I had patients basically, you're stuck. They go, I just need a little help. And then we work on lifestyle modification. I want you to basically really work on physical activity, get your steps in, try to get a high-intensity interval. Let's clean up the diet and maybe use it sparingly. I'm OK with that. Maybe three months a year, like during the holidays, they know that Thanksgiving, Christmas,
Starting point is 00:38:03 too much temptations. And then after that, they go that Thanksgiving, Christmas, too much temptations. And then after that, they go, okay, I'm fine. So if you can taper off or maybe use it sparingly, I think it's perfectly fine. There is a product that's called CaloCurb. It's a natural herb, which actually activates basically the bitter receptor in the small intestine and it releases your natural GLP-1 and CCK to inhibit appetite. So I have some of my patients I go, let's see if you can use this and get off your- Yeah. I mean, there's a whole set of ways of naturally to raise GLP-1, whether it's certain compounds, for example, Himalayan Tyree Buckwheat works in the lower intestine with these taste
Starting point is 00:38:45 receptors to increase GP1, various kinds of polyphenols and other things can help. So it's definitely not just the drug that can do it. But there are, you know, concerns around side effects. If you tend to use these things improperly, if you don't have proper guidance, if you don't understand the risks, you can get anybody, as you mentioned, like you said, to the growth hormone analogs, or you can end up with maybe other untoward side effects you're not even aware of. So what are the kinds of things that people should be worried about or concerned about with peptides? Dr. Well, I think in general, peptides are generally very safe and efficacious. The ones that are of concern are the growth hormone-releasing peptides.
Starting point is 00:39:30 And MOTC, I did see one person. That's for the mitochondria to make it for better energy. I've had one with anaphylactic. And I had another doctor friend. He's a co-founder of Clinical Peptide Society. He also saw one anaphylactic reaction. So just got to be careful the the rare um side effect but you know medications like you know even taking you know
Starting point is 00:39:52 aspirin you can get anaphylactic so yeah i agree i mean guys taking aspirin just almost bled to death in the stomach so yes yeah um so the the uh this field is is just exploding, but at the same time, there's a lot of pushback from the government and the FDA to try to regulate these in ways. And one of the things that I caught earlier that you said, which got my attention, was that there's not a lot of human clinical trials. A lot of the data you're talking about is animal studies? Well, not all peptides. One of the peptides I just published was on thymus and alpha-1, and it's open access, so you can find it. It's the comprehensive review of the safety and efficacy
Starting point is 00:40:39 of thymus and alpha-1 in human clinical trials. So there's 11,000 patients worldwide that have been on clinical trials on thymus alpha-1. And basically, it's been safe. I mean, no side. And the efficacy based on those trials? Yeah, I mean, efficacy, most of them basically improved. I mean, they were doing studies like hep B, hep C. Now there's newer drugs and all that.
Starting point is 00:41:02 But back then, they had nothing. So they were using thymus alpha one and for chronic hep b and this is like interesting if you look go back in history you're reading it and it's like well you know there's better ones here now but anyway yeah well i remember seeing china during covid that there was some studies on ta1 and on covid treatment and some studies shows to reduce mortality And unfortunately, one compound pharmacy got this whole peptide upset with the FDA, and it was the compound pharmacy advertised that there's a cure for COVID. Oh, wow.
Starting point is 00:41:32 And then you say cure to the FDA with COVID, oh, you're going to be shut down. That's why they were upset. So that was one of the reasons why it's on the banned list. But it has been approved as an orphan drug in the 70s. And when they did the first clinical trial, were children born without thymus glands. And they, even FDA goes, let's get this going. Let's see if we can help these children.
Starting point is 00:41:56 And it was remarkable. It saved their lives. So this is before thymus gland formed, the precursor of it. But anyway, it's like, hey, it's safe. It's around. So that's why I wrote the paper, to basically show it to these attorneys who are going to eventually file a lawsuit against the FDA about this. Yeah. Well, it's a whole problem.
Starting point is 00:42:20 Often, you know, we find that supplements or things that really work well tend to be regulated in ways that are confusing to me because they work they're safe there's a long history of use there's plenty of evidence uh and they're bioidentical compounds or things that the body makes or uses and and i just find it sort of striking that you know maybe i i don't want to be a conspiracy theorist but you know there's seems pushback maybe from pharma to to kind of try to reduce access to certain compounds because they work too well. That's my... Well, you know, I have theories there too, but anyway, I just really want for people out there, especially your group, is to get onto savepeptides.org and hopefully you'll have that
Starting point is 00:43:03 on your podcast there. And just, it's really quick to sign the petition, send it to your friends and family. We need more signatures. And it's grassroots, and I go on a lot of radio shows and podcasts, and we get a little blip after the podcast. That's great. Yeah, I think it's important.
Starting point is 00:43:20 What Edwin says is important. We want to be able to have access to compounds that can support our health and we have to be, they have to be used judiciously, they have to be prescribed by a physician, you have to be under someone's care, who knows what they're doing, but in that context they should be available to be used and what's happening now is a restriction on that use. So if you go to savepeptides.org, savepeptides.org, you can basically sign a petition and that will help to the FDA to perhaps reduce their restrictions or potential ban. They're not banned yet. There's a proposed ban.
Starting point is 00:43:57 So I think we're going to still see it's being fought. There's a lot of legal cases going on about this. In terms of a few other use cases, you know, one of the things that happens as we get older and often a big problem for people is energy. We lose energy. And one of the fundamental things that happens as we get older is our mitochondria don't work as well. We don't produce energy from food and oxygen as well. So basically our engine starts to slow down. And we see, obviously, you see a two-year-old running around, bouncing up the walls and, you know, full of energy. And you see like a 92-year-old and they're moving super slow. And a lot of that has to do
Starting point is 00:44:35 with mitochondria. Oh yeah, mitochondria's function is huge. So talk about why the importance of mitochondria and what the use of peptides are in helping to improve the function and health of the mitochondria and how they work. So as you mentioned, mitochondrial function is critical for optimal health and we check in our office NAD levels. So I say Nancy Apple Dog because it's nicotinamide adenine dinucleotide. And it's not something you can really check easily at a regular lab. So you use a special lab. Yeah, it's GINfinity Lab.
Starting point is 00:45:11 GINfinity. Can you spell that? Yeah, it's a finger stick. It's J-I-N-I-F-I-T-Y. Okay, we'll put that in the show notes, everybody. But GINfinity Lab to check your NAD levels. Is that something you can order yourself or you have to go through it yourself? I think you can order yourself or you have to go through it? I think you can order yourself. And basically, it measures your white blood cells intracellular NAD levels. So it's a fingerprint test. There's like five whole circles. And
Starting point is 00:45:37 if we draw your blood a little extra, we'll just put it on this and we let it dry. And there's the little droppers you have to do, but we send it in bulk rather than one at a time because things get lost in the mail. So anyway, but the thing is that my wife's NAD level was low. It was anyway, 20, not optimal. And I was 30, a little better, but I always had more energy than my wife.
Starting point is 00:46:01 And so I told her, let's try this product that has NMN so I tell my patients like Nancy Michael Nancy and it's it stands for a big chemical word but it's a precursor of NAD so a month later we rechecked and she went from 20 to 40 I went 30 to 50 and it's amazing because I like to ride I'm not a professional cyclist but anyway I like to ride. I'm not a professional cyclist, but anyway, I like to ride with younger people. Yeah, you keep up? Yeah, I try to keep up. Did you do better?
Starting point is 00:46:30 Oh, yeah. I mean, there was a group ride. They go, oh, you're so young. I go, no, I have a higher NAD level. So this is like the enhanced Olympics then, right? Exactly. You know what? All the athletes are taking NMN to improve their energy, but you can measure it. And the
Starting point is 00:46:45 second thing, I mean, that's not a peptide. No, it's a supplement that the FDA has now banned since March of 2023 against Amazon. It was available for over 10, 15 years. David Sinclair. Yeah. It's still available, but it's- It's through physician's office, but not on Amazon. So it's it's through physician's office but not on amazon yeah so it's it's it's harder and harder but i think david sinclair is uh making a drug so yeah yeah it's a shame it's it's natural probably yeah exactly anyway so so you're talking about how to optimize even an ad with another peptide no it's not a peptide it's a b vitamin but the other thing is what i'm going to do is in conjunction with that yeah is that you've got to optimize sleep too. So I think epithelium can help with better sleep.
Starting point is 00:47:29 And you'll get your REM up. And, you know, a lot of people have adrenal fatigue. So you've got to get that deep sleep, REM sleep up and get good quality sleep. So it's not quantity. It's also quality. But anyway, there is a peptide, since we're talking about peptide, it's MOTSC, it's a mitochondrial peptide. And it just basically turns on the mitochondria and works faster.
Starting point is 00:47:54 And when I've tried it, the first dose is like, okay, all good. Second time I tried it, I was like, hmm. And the third time was, damn, this is great. So is this something you use every day long term? No, I do it, hmm. And the third time was, damn, this is great. So is this something you use every day long term? No, I do it intermittently. But there's so many different compound pharmacies that make it. And the problem is I'm a wuss when it comes to injection and if it burns. I don't like to burn.
Starting point is 00:48:20 And the ones that I was using never burned. And then they stopped. Taylor made, you know, stopped making it. And we had to go elsewhere. So I prefer IV pushes. If I get an IV of nutrition, I'll say do a MOTC push. It doesn't burn at all. It feels great.
Starting point is 00:48:37 But I do it individually because most MOTC burns, and I'm a wimp. I mean, I can go in cold water. I love cold plunge, but i don't like to burn could you use it every day well you're supposed to um you can do the protocol is 10 milligrams once a week or five milligrams sub cube twice a week um you could go a little further if you have an event like you're you're you're trying to like yeah run faster like you have a marathon coming up or something like that but in general just uh once to two times a week and and are there any risks to it well one like i said before um i did have one patient that developed anaphylactic reaction and she was she thank god she was by she lived by herself but she
Starting point is 00:49:22 had a wherewithal to basically knew something was wrong. So, she was in Arizona. She ran outside. Thank God her neighbor was there. She said, call 911, and she collapsed outside. And then she basically, like a month later, goes, can I try it again? No. Right.
Starting point is 00:49:40 Never. But she goes, I lost so much weight. It's so good. So, that's another benefit with MOTC. It helps the weight loss. Yeah. Speeds up metabolism. Yeah.
Starting point is 00:49:51 Converts your white fat to brown fat, too. So it increases energy production and burning, right? So it increases your metabolism, literally. There's a few other mitochondrial peptides, like SS31 and humanin. Can you talk a little bit about how those work, what they do, how they're used? Yeah. So SS31 is another interesting mitochondrial peptide that can help. I kind of explained to my patients that, you know, as you get older, it's like your underwear, you wear that same underwear over time, you lose that elastic. So your mitochondria gets weak and SS31 kind of snaps it back in place.
Starting point is 00:50:30 So then basically the, you know, the electron chain where you produce all the ATP and energy, basically it's better form. So if the confirmation of the mitochondria doesn't work, it gets weak, then that's why your production gets weak. So it doesn't speed up the mitochondria doesn't work, it gets weak, then that's why your production gets weak. So it doesn't speed up the mitochondria, but it helps. Basically their structure. Exactly.
Starting point is 00:50:51 And what about human end? I haven't used that yet. Have you? A little, yeah, a little. Okay. So I think there's, I mean, like you said, there's 300,000. I don't know how many. I know.
Starting point is 00:51:03 I get on podcasts and always someone wants to stop me. What about blah, blah, blah, blah. I never heard. Yeah. And then they'll go one hour talking about giving me a lecture. Yeah. Yeah. So I don't know all of the peptides.
Starting point is 00:51:17 So the question really is, you know, when you're seeing a patient and we talked a lot about, you know, peptides where everything's going to be in the show notes here. So people can learn more about them. We're going to put links to the studies you mentioned. We're going to be at links to save, save peptides. Yeah. And if you can donate to, that'd be great.
Starting point is 00:51:35 It's time to get a phase one clinical trial for BPC one, five, seven. Yeah. So you've got a few million dollars to do some research. I don't think it's millions, but no, no,
Starting point is 00:51:43 it's important. And I think, you know, even $20 will hold. And the more research that we have, the better off we're't think it's annoyance, but just... No, it's important. And I think, you know... Even $20 will help. The more research that we have, the better off we're going to be to understand these. But they are kind of exciting new therapeutic in medicine that I never really learned about,
Starting point is 00:51:55 except maybe insulin. And I think that they help across a range of human functions that tend to decline as we get older. So they seem to be sort of an adjunct in longevity and a lot of people in the longevity space are using this. You know, what are your sort of top longevity peptides? Well, number one is epithelium. That one you mentioned. Twice a year, 10 days, reset the pineal gland. Exactly. Okay, got it. And in terms of the, you know, the kind of use-
Starting point is 00:52:29 The second would be thymosulfone for your immune system. Yeah, those two, yeah. So there's some heavy hitters. There's some powerhouse peptides that are kind of go-to for you, that are part of your standard practice. But when someone comes in to see you as a patient, you take their medical history, how do you sort of begin to think about,
Starting point is 00:52:46 you know, which are the right peptides for each person and how long to use them and how to give them? And it just seems like, you know, we don't really learn how to do that in medicine. Well, what I do is when a patient comes to see me, we actually, it's a pretty extensive morning visit when they come. And we do so many different tests. And we're looking for DNA damage. We're looking at your genetic SNPs. And we're also looking at leaky gut. We're looking at many different things that most conventional doctors don't check,
Starting point is 00:53:27 like oxidative stress protocol to see if you have cell membrane damage. And so anyway, the thing is, I have this foundational triangle of health and a lot of people have different versions of it, but it's hormones, leaky gut, fix your liver to remove toxins, sleep exercise, and then in the middle is nutrition. So I've been nutritional as well. Try to get that balance and then in the middle is nutrition. So I've been nutritional. So try to get that balance and then later add peptides. I don't do that first. I mean, unless... So like phase two?
Starting point is 00:53:52 Yeah, two or three, just add more or something like that. But unless they have an acute injury, it's like, okay, let me inject and... So if their immune system is down or they've got an injury, there's things you'll pull out. Occasionally I'll pull out. But generally, we do a biological age too in all our patients. So anyway, I look at the intrinsic age and later I have to tell them you're older than your chronological age or younger and they always say, how do I get it better?
Starting point is 00:54:17 So I'm publishing another paper and I just don't have time. But we submitted a paper and it's being reviewed and I'm trying to get that open access quickly. And so it's an interesting thing. I'll just tell you, Alzheimer's patient, 80 years old, could not finish a sentence. And in a year, his cognitive tests significantly improved. He started at 2%. He was like, failed. Yeah.
Starting point is 00:54:46 And now he's trading stocks. He said, and his biological age reduced by eight years. Wow. And his telomeres increased in size. Is he making money on the trading stocks? Yes. But the beauty, I'm not going to tell you what the protocol is, but wait for the paper. Because the paper has to be published first.
Starting point is 00:55:04 I don't want to curse it. Oh, interview me next time okay we'll link to it eventually the show notes but i'm dying to know what that protocol was because you're talking basically about reversing cognitive decline using uh i know i i i'm really excited about that x price because i think i'm going to submit it this is just one case yeah but i have other cases yeah oh i have several yeah i i am i am busy in my practice do you want do you want to maybe um share also a little before we get into sort of some of the case studies do you want to share a little bit about the the peptides related to sleep because there's a there's a number of peptides that can help improve sleep and there's several 70 million americans who have some type of sleep disruption falling asleep stinging i think
Starting point is 00:55:48 the best one honestly i'll just start with that but there are other peptides there but i mean i mean i've used dsip delta sleep inducing peptide and ryan smith and i were doing it at same time texting oh my god my sleep's so good know, because we both struggle with sleep. But then eventually it stopped. It was like tachyphylaxis. It stopped working. Yeah. And we were doing it every day.
Starting point is 00:56:10 And then we figured we had to put it back down to like three times a week or something like that. And then. So that's DSIP. Yeah. I stopped using that. Epithelium is phenomenal. Epithelium.
Starting point is 00:56:21 Over time, you're, because you're generating, you're turning on three genes for melatonin production. So it's phenomenal. So over time, you're not going to require some sleeping. I have people that are saying, OMG, I am sleeping great. So that's your top- But it took me three years because I was doing it twice a year. And then on the third year, I was doing it just to get my biological age down yeah that's amazing with are there any others that are helpful for sleep
Starting point is 00:56:50 uh cjc 1295 when I first took it I forgot that uh it burns like you not burning injection but you you feel like you're on fire and I remember injecting and um it's worse if you drink alcohol if you have wine so I had wine and then I injected and I felt like I was on fire but I was a little drunk so I fell asleep quickly but I had a brief moment of empathy of women going through hot through menopause I'm getting hot flashes because it's like if this is a hot flash just shoot me because I can't survive yeah this is terrible yeah so but then I slept like a baby. So is that something you do every day, CJC? Five days a week.
Starting point is 00:57:30 Five days a week. You don't want to burn out the pituitary gland. So I have a peptide class we teach healthcare providers, and I have a class March 16th. It's almost sold out. Now, is this a curriculum? Is this something that a healthcare provider would sign up for and is it a multi-part course that's a one-day introduction to peptides but we teach seven new peptides that's um in case the fda takes things out so um and um anyway it's exciting it's on clinicalpeptidesociety.com
Starting point is 00:57:59 if you're interested i'm a co-founder of it it's going to be in orlando march 16th so that's an in-person seminar. Yeah, in-person, not Zoom. I had someone from Beverly Hills sign up. And they go, I thought it was Zoom. It's like, it says right there. So say the website again. ClinicalPeptideSociety.com.
Starting point is 00:58:19 I'm a co-founder of Clinical Peptide Society. We're going to put that in the show notes if you're a practitioner and you want to learn more. Because it's hard to learn about this stuff. Yeah, you're actually, I remember you called me. I did. Like, what the hell about these peptides? You know what Mark said? He goes, teach me peptides in five minutes. I said, Mark,
Starting point is 00:58:35 I can't do that in five minutes. Just read my book. And he goes, I don't want to read the book. Give me the cheat sheet. I want the cheat sheet. So I mailed him the book. You read it and you're really good. I'm like watching you. It's like you evolved. I'm learning. I'm sheet. I wanted the cheat sheet. So I mailed him the book. You read it, and you're really good. I'm watching you. It's like you evolved. I'm learning.
Starting point is 00:58:47 I'm learning. I like I'm a sponge. I like learning stuff. So we've got three and five minutes. This is like peptide. Three and five minutes of life. It's true. Not fair.
Starting point is 00:58:58 But what I was looking for, because it's hard to get, is like a cheat sheet. Okay, here's the dose of the peptides. Here's the frequency of the peptides. Here's the use case. Here's how to mix them up. Here's the amount of units you get. We teach that in the class. And then we do offer like essential knowledge. It's not a certification, it's essential knowledge of clinical use of peptides. So you have, there's a test and there's 80 questions. Like a certification kind of thing? Yes. But we don't call it certification.
Starting point is 00:59:25 We call it essential knowledge. Yeah. Because we worked with AMNG, Age Management Medicine Group. We would love for you to come and speak there. Sure. Yeah. I think this is such an important deal. I'm on the planning committee.
Starting point is 00:59:37 Okay. Got it. You're giving me a pitch now to go give a talk. I hear you. I'll be in November. If it's in some place fun and beautiful, no, it's definitely an you. I'll be in November. I mean, someplace fun and beautiful. No, it's definitely an option. It'll be Utah. Utah. Oh, my daughter lives there. Oh, cool. Salt Lake. I don't know if there's actually one. Okay, Park City. That's close enough to Salt Lake. Yeah, close. Okay, so that sounds good. The other thing I kind of want to hear from you,
Starting point is 01:00:02 you know, is, you know, there's an issue around cost, right? These are not cheap. And so people might be listening and get excited about it, want to try it, and then they go look it up and it's like, so expensive. Well, what's expensive? It's all relative. I mean, some patients, it's investment of their life and their health. And I have people of all different backgrounds. And when it comes to their health, though, I mean, it's like there's not many alternatives. When you come to see me, you usually failed everything else. So it's hundreds of dollars sometimes for a fertilizer.
Starting point is 01:00:40 I mean, but the thing is, it's trying to get you from A to B, and then over time, you know, if you use it sparingly, it's not... Yeah. So they're sort of like kind of the fix things and get you healthy, and then you can use them as sort of maintenance intermittently. Right. If you lose weight or, you know, things get better, and, you know, so it's... I give you the path to get well.
Starting point is 01:01:04 Yeah. It's up to the patient to follow the path to get well. It's up to the patient to follow the path. And I've always been in business because they usually follow up the path. There you go. Never shorten your path. But a lot of my patients do. I'll try better. Yeah, if we do a good job at fixing the food system and maybe dealing with a new way of thinking about chronic disease,
Starting point is 01:01:21 we might have a reduction in business, I hope, but there's going to be sick people for a long time. In terms of case studies, can you share a few kind of highlights from your career? You mentioned the Alzheimer's case. You mentioned your son with IT band. You mentioned yourself a few times. I've certainly one woman who slipped chasing her grandchild on carpet and her shoulder popped out got worked up and they said you need a shoulder replacement so she said I want a second opinion and she drove like two hours to see me she used to live closer but she wanted to see me and she drove like two hours to see me. She used to live closer but she wanted to see me. And she had five tears in her shoulder, supraspinatus, infraspinatus, the labrum tear,
Starting point is 01:02:13 and two other tears. So I said, let me inject with ultrasound guidance. And she could not even put deodorant underneath her arm. She could not. Wow. She was limited. But she didn't want to have surgery because she wanted to try this alternative way and there was no one to take care of her. Her husband passed away so she didn't have anyone to help her after shoulder surgery. So each month, she came once a month and I've told her five times her movement with these peptides. I used BPC and thymus and beta-4. That's it. No stem cells, no exosomes, no growth factors, just peptides.
Starting point is 01:02:54 I knew where the tears were and I basically injected there. And each month, it just got better. By the third month, it's like, you know, you could see significant improvement. By the fifth month, I was telling her her i probably have to inject your good shoulder because you're going to realize your the damaged shoulder is um you're gonna get so well so a year later i mean she did come back she goes you know my good shoulder i mean the one that you injected feels like it's super young and she likes the golf she goes you, you got to fix my other slice of golf. That's amazing. So it's amazing. Yeah. I mean, it's regenerative. And I gave a talk. You just gave her once a month in the joint, BP 157 and TB4. So I gave a talk to traumatic
Starting point is 01:03:39 brain injury to Mark Corden's workshop to healthcare providers. And I was talking about peptides to help the brain. And I kind of got off label and was talking about some of these interesting cases. And there was a retired Air Force orthopedic, he was like a captain in the Air Force, and he got up, put his finger in my face face and he goes, damn you, you're going to ruin the orthopedic careers. And I say, yes, me by myself is going to ruin all these orthopedics. No, you can be educated and offer this to your patients. So I'm excited.
Starting point is 01:04:18 There is a doctor that graduated from Dominican Republic and he found me and he goes, I want to become an orthopedic surgeon and I need to get something published. And my dad's an orthopedic surgeon in Miami. It's like, oh, so we've been talking, we have two clinical trials. He needs to get IRB approval. I go, I don't need IRB approval. I don't have anything to prove but i think for your future career you should get irb approval yeah uh and i told them what's some sites you can go to
Starting point is 01:04:51 and uh hopefully we can get this quickly approved and start to study that's amazing because one is we're going to do MRIs before you have before the knee injury like acl and then do a month into the knee for like three times, like once a month for three times, and then in six months repeat the MRI. Because I did a study published and it was a subject of people recalls, they didn't feel better. But orthopedic surgeons want to see. Yeah, yeah. Like what, for example, heal a meniscus that's torn? Yeah, my mother had a partial meniscus tear and I actually, I flew to Pennsylvania because she was getting, I couldn't figure out how bad it was. And when I saw the airport, it was like, oh, Houston, we have a problem. She couldn't even turn like 180. It was like just really slow. And so when I got home,'ve been i injected her and then that
Starting point is 01:05:48 go in any joint or just in the joint it has to be in the joint yes you could try around but the best is in the joints it's easy to i mean anyway uh for me it's relatively easy yeah yeah but the thing is that uh i injected like the later like that was October, and then Thanksgiving, I was there and injected. So I flew back to Pennsylvania, and then Christmas time, I injected her. And I mean, Christmas time, she didn't need a third injection, but she goes, since you're here, just inject me. So my mother is now a peptide junkie. And for osteoarthritis, too, would it help?
Starting point is 01:06:18 Yes, it can help with it. It can help with it. Yeah. And they did studies in animals with arthritis. They induced arthritis in the paws and gave BPC, and it has reduced the... The regrow cartilage? I think to regrow, you do need the stem cells. Yeah, stem cells. So, last thing I want to sort of just touch on, you know, the sourcing and finding peptides and finding practitioners and
Starting point is 01:06:43 safely doing this, because it's a bit of a wild west out there. So people are getting it off of unregulated websites and you don't really know what you're getting and there's not really, there's risk to it. So how do you sort of find the right practitioner and use the right compounding pharmacies to find the right peptides? Dr. Well, on our Clinical Peptide Society, we do have practitioners who've taken the, quote, they passed their tests. So they've had training. Dr. They have training. So anyway, they basically have the essential knowledge on how to use peptides, and they basically do a lot of peptides in their practice. So you can look at per state
Starting point is 01:07:25 where they are located. And anyway, I don't know all the doctors in America, but I do know some people that I deal with. But we usually, I mean, there's only about 20 compound pharmacies that are 503A that produce sterile injectable. 503 means it's like it's good for human use and it's regulated by the FDA. Exactly. State inspected. State inspected and you can be confident in the compounds that are. Oh yeah. And they check for basically third-party inspection for basically any mold or bacteria. And you list those on clinicalpeptidesociety.com? I don't even know all the 20. I have several
Starting point is 01:08:08 but I don't know all 20. To me, I know most of them but don't know all of them. But I don't list it all there. But I will give you a personal list. What I use. So basically you have to find someone who understands the science behind it, who knows
Starting point is 01:08:26 how to use them appropriately. For example, what you're sharing is some of these you only take for 10 days twice a year, or some of them you take periodically. I'd love for you to take my class. Yeah. I can give you the next level. OK, great. I'm coming.
Starting point is 01:08:38 I'm coming. So I think this has just been such an enlightening discussion. I think people can learn more about your work by going to clinicalpeptidesociety.com. Definitely sign the petition and say peptides.org. And of course you can check out Dr. Lee's books, The Fountain of Youth with Peptides, and his new one called, is that the one? That's the newest one. That's the newest one. Yeah. So this has really been a fabulous conversation. I've learned a lot, and I think, well, not everybody can easily access these compounds. It's something to kind of explore, particularly if you have certain conditions and issues that really respond well to this, that we talked about. And not all peptides are injectables.
Starting point is 01:09:18 There are peptides that you can take by mouth. Orally. orally and uh there is a booth here uh at this uh show called health jevity and it's only through doctors um so if they have an account with health jevity i'm kind of helping him uh uh kind of with with that journey so we're kind of um i get no world yeah so the shirt really helped the gut healing like BP 157 or another. So yeah. So I hear some pretty cool products there. Well, thanks for your dedication in this field, for educating all of us, for writing the book,
Starting point is 01:09:53 for teaching the courses, for fighting the fight against the FDA. I really appreciate it. I feel like I have this flag up the mountain. Yeah. Well, thank you so much for what you do and hope everybody loved listening to this podcast and thanks for being on The Dr. Pharmacy. Yes. Yeah. Well, thank you so much for what you do. And I hope everybody loved listening to this podcast. And thanks for being on The Doctor's Pharmacy.
Starting point is 01:10:07 Yes. Thanks. Pleasure. Thanks for listening today. If you love this podcast, please share it with your friends and family. Leave a comment on your own best practices on how you upgrade your health. And subscribe wherever you get your podcasts. And follow me on all social media channels at DrMarkHyman.
Starting point is 01:10:24 And we'll see you next time on The Doctor's Pharmacy. I'm always getting questions about my favorite books, podcasts, gadgets, supplements, recipes, and lots more. And now you can have access to all of this information by signing up for my free Mark's Picks newsletter at drhyman.com forward slash Mark's Picks. I promise I'll only email you once a week on Fridays and I'll never share your email address or send you anything else besides my recommendations. These are the things that have helped me on my health journey and I hope they'll help you too. Again, that's drhyman.com forward slash Mark's Picks. Thank you again and we'll see you next time on The Doctor's Pharmacy. This podcast is separate
Starting point is 01:10:57 from my clinical practice at the Health and Wellness Center and my work at Cleveland Clinic and Function Health where I'm the Chief Medical Officer. This podcast represents my opinions and my guests' opinions, and neither myself nor the podcast endorses the views or statements of my guests. This podcast is for educational purposes only. This podcast is not a substitute for professional care by a doctor or other qualified medical professional. This podcast is provided on the understanding that it does not constitute medical or other professional advice or services. If you're looking for your help in your journey, seek out a qualified medical practitioner. You can come see us at the Ultra Wellness Center in Lenox, Massachusetts. Just go to ultrawellnesscenter.com. If you're looking for a functional medicine practitioner near you, you can visit ifm.org
Starting point is 01:11:37 and search find a practitioner database. It's important that you have someone in your corner who is trained, who's a licensed healthcare practitioner and can help you make changes, especially when it comes to your health.

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