The Dr. Hyman Show - How to Reduce Seasonal Allergies Starting This Week

Episode Date: April 6, 2026

Seasonal allergies aren’t just about pollen—and if you’re only treating symptoms, you’re missing the real problem. What if your allergies are actually a sign that your immune system is out of balance? In this episode, we break down what’s really driving allergy symptoms and what you can do now to calm your immune system at the root. Here’s what you need to know before this allergy season gets worse: • Why allergies are a sign of immune dysfunction—not just a reaction to pollen • The hidden role of gut health, inflammation, and your microbiome in driving symptoms • Key nutrient deficiencies and environmental exposures that make allergies worse • A functional medicine approach to reducing symptoms naturally by restoring balance and not just blocking histamine You don’t have to suffer through allergy season every year. When you address the root causes, you can retrain your immune system, reduce your reactivity, and build long-term resilience. Visit ⁠functionhealth.com for 160+ lab tests at just $365 a year. Join the 10-Day Detox to Reset Your Brain and Metabolic Health: https://drhyman.com/pages/10-day-detox Have a question you’d love answered on Office Hours? Submit it here.

Allergy is not a pollen deficiency. They're a sign of an immune system that's out of balance. Pollin isn't the problem. It's the trigger. The real question is, why is your immune system reacting as if something harmless is a dangerous invader? Welcome to office hours. This is our dedicated one-on-one space to go deeper, get clear, and explore what truly moves the needle for your health. I'm Dr. Mark Hyman, and each week we're going to pull back the curtain and share the insights, the research, the lessons that don't always make it into our conversations with guests.

Because at the end of the day, you are the CEO. of your own health. And for many of you, your family's health too. And you might not feel it all the time, but you have far more power in agency than you realize. I'm glad you're here. But this episode is brought to you by Function Health, empowering you to live 100 healthy years with over 160 lab tests for just $365 a year and use the code mark 2026 to get $50 off your membership. If you think seasonal allergies are just about pollen, think again. Every spring, millions of people brace themselves. The tissues come out. They antihistamines come out, the eyedrops, the nasal sprays,

and we're told, well, it's just allergy season. But what if that's not the full story? What if your allergies aren't just about what's in the air, but about what's happening inside your body, right? Because not everybody gets allergic. So it's something about your body that's not working right. Here's the truth. Allergy is not a pollen deficiency.

They're a sign of an immune system that's out of balance. Pollin isn't the problem. It's the trigger. The real question is, why is your immune system reacting as if something harmless is a dangerous invader. In functional medicine, we always ask the question, not just what's happening, but why is it happening? Why is the immune system so pissed off? Why is it reacting? Why is it a high alert? Why is it lost as tolerance for things that shouldn't be a problem like pollen? And when someone has seasonal allergies, I don't just think about the outdoors. I think about the gut, right? It's all

comes down to the gut. I think about inflammation. I think about nutrient status. I think about the microbiome. Because, you know, 70, 60, 70 percent of your immune system lives in your gut. And if that whole system is disrupted, your body can start firing at things that were never meant to be threats. So today, I'm going to walk you through what's really happening in the body during seasonal allergies. We'll talk about the root causes that make your immune system hypersensitive. We'll explore the powerful gut immune connection. And most importantly, I'm going to share practical science-based tools you can use to calm your immune system and reduce your symptoms naturally. Because you don't have to just survive allergy season. When you address the root causes, you can actually retrain your immune system,

and that changes everything. So what's actually happening, right? Let's break down what's happening inside the body. When you're exposed to something like pollen or ragweed or tree dander, your immune system is supposed to evaluate and go, ah, this is harmless, no big deal. But in someone with seeds from allergies, the immune system misidentifies that harmless substance as a threat.

It produces something called IGE antibodies. Now, these are immune proteins designed to defend you against parasites and worms and real dangers, but instead of targeting something harmful, they attach to cells called mass cells. And when you're exposed to pollen, these mass cells release histamine and other inflammatory chemicals. And histamine is what causes the classic symptoms,

sneezing, itchy, watery eyes, running nose, congestion, even brain fog and fatigue. Now here's the important part. Histamine itself isn't bad. It's part of your body's defense system. The problem isn't that your body makes histamine. The problem is that your immune system is overreacting. And that overreaction doesn't happen in a vacuum.

Now, in functional medicine, we see allergies as a form of immune dysregulation. The system is lost. It's tolerance, meaning tolerant of stuff. Like if you eat a peanut, you shouldn't be reacting. Or if you have a pollen, you shouldn't be reacting. It becomes intolerant. And it becomes hypervigilant. And when that happens, the threshold for reacting gets lower and lower.

So just a little bit can kill you, right? So we have to ask, what lowers that threshold? Why does one person walk through a field of pollen with no problems? and another person can't stop sneezing for weeks. This is where we start looking deeper. Because in many cases, seasonal allergies are connected to a lot of different things that people don't look at, like their gut barrier. When you have a leaky gut,

and the barrier between the inside world, the outside world breaks down, you get food and bacterial proteins that cause damage, and you get a leaky gut. And it can be also caused to an imbalanced microbiome. It can be from low-grade inflammation from other things. Nutriot deficiencies. Like if you're low in vitamin C and zinc and vitamin A and vitamin D, these all regulate immune function. Also, if you have environmental toxins like heavy metals or mold

or pesticides, that also stresses the immune system. Now remember, about 60 to 70 percent of your immune system is in your gut. And if your gut lining is compromised, those partially digested food particles, the toxins, those bacterial fragments, they cross into the bloodstream and they activate the immune system. You're basically one cell away from a sewer within your gut. And that cell lining breaks down, you're in trouble. When your immune system is constantly stimulated like that, well, it becomes primed to overreact. So when the pollen shows up, it's not just responding to pollen, it's responding to a state of chronic irritation. It's a very different framework than you're allergic to spring. Allergies are often a symptom of a stressed, inflamed, imbalanced immune system. And the good news is

when you calm that system down and restore balance, you can dramatically reduce how intensely your body's reacting to those allergens. So let's talk about what drives that imbalance in the first place. What are the root causes of why your immune system is so reactive, right? If seasonal allergies are really a sign of immune balance, like the question is, what's throwing the immune system off in the first place? In functional medicine, we look for the drivers of the causes, because symptoms are clues. They're not random. The body's always responding to something. We just don't always find out what that something is, but that's what functional medicine does. It helps you find out there's something. And it's what we do at my clinic at the Ultra Wellness Center. It's what good functional medicine

and doctors do. There are a few major root causes that I see over and over again of people who struggle with seasonal allergies. The first thing is the gut. Start with the gut. As I mentioned, that's where your immune system lives. Your gut isn't just a digestive tube. It's an immune organ. And your microbiome, those trillions of bacteria living inside you, play a huge role in training your immune system. A healthy microbiome teaches your immune system tolerance, right? It helps you distinguish between friend and foe. But when the microbiome is disrupted from antibiotics, from ultra-processed food, low-fiber diet, chronic stress, environmental toxins. The whole regulation and education of immune system breaks down. We lose bacterial diversity. We lose beneficial bacteria. The

gut lining becomes more permeable and leaky. And when that happens, the immune system is constantly being provoked. Now, if your immune system is already irritated, it's on high alert because of what's happening in your gut, it's way more likely to overreact a pollen. It's not a coincidence. It's just biology, my friends. Now, the second. The second major driver of allergies is chronic inflammation. Now, inflammation isn't inherently bad, but it's protective, actually. But when it becomes chronic, which can be driven by lots of blood sugar spikes and belly fat, processed foods, lack of sleep, chronic stress, environmental toxins, low-grade infections, it lowers your immune tolerance threshold.

So think of it like this. If your inflammatory bucket is already full, it doesn't take much more to cause overflow. Palm becomes the final straw. And this is why two people can be exposed to the exact same environment and only one develops severe symptoms. Right. It's not the exposure. It's the internal terrain. We call it the biological terrain.

There's another cause also, which you talk about. And this is the third root cause that most people now think about, which is your nutrient status. Your immune system requires specific nutrients to regulate itself properly. Vitamin D is one of the most important immune modulators we know of. Sink plays a role in immune signaling. It's really important. Vitamin C plays a role in his health. histamine breakdown. Omega-3 fats help balance inflammatory pathways. If you're deficient,

which many people are, your immune system doesn't function optimally. It can become more reactive and less regulated. So sometimes allergies aren't about adding more medication. They're about correcting deficiencies. Next big cause I want to talk about is the total environmental load of toxins. We live in a world our biology was not designed for. Indoor air pollution, a mold exposure, petrochemicals, heavy metals, synthetic fragrances. It's, everywhere. Your immune system is constantly processing these exposures. Now, if your overall toxic burden is high, your immune system is already working over time. And when spring pollen arrives, it's just one more input into an already overwhelmed system. And again, pollen isn't the sole cause.

It's just a tipping point. So instead of just suppressing histamine, we want to calm and retrain the immune system. Every spring, millions of people search for antihistamines when the allergies hit. But they're missing the real question. What was your immune system doing before spring arrived? Because pollen isn't the root cause. Pollin is just the trigger. And I've seen this pattern in patients over and over for decades. The ones who suffer most aren't just unlucky. They often have high levels of high sensitivity CRP, high asinophils, which is a white blood

cell for allergies, and dysregulated antibodies, particularly IGE. So a little pollen feels massive because their baseline inflammation is already high. It's accumulated through chronic stress, through our ultra-processed food, poor sleep, metabolic dysfunction, and spring just turns up the volume on something that was already playing. So here's what makes this worth paying attention to. Chronic low-grade inflammation doesn't stop at allergies. It shows up as stubborn weight gain, mental fog, energy that never fully returns, leading to much bigger problems down the road.

Most people medicate the reaction and very few measure the cause. It's time to stop guessing. Check your health with function. Function gives you access to over 160 lab tests every year, including advanced lipoprotein testing. It's time to stop guessing. Check your health with function. Go to functionhealth.com slash mark, and if you're one of the first 1,000 people this week, use the code Mark 2026 for a $50 credit toward your $365 a year membership.

That's functionhealth.com slash mark and use the code Mark 2026 today. So what's the functional medicine approach? How do you deal with allergies by dealing with the root cause naturally? Once we understand that seasonal allergies are really about immune balance, the question becomes how do we restore immune balance, right? In functional medicine, we focus on removing the triggers, getting rid of the bad stuff, and supporting the body's natural regulatory systems, adding in the good stuff.

So let's think about this in four major pillars. Number one, lower the inflammatory load. Focus on diet. If your immune system is already inflamed, it's primed to overreact. And the fastest way to reduce inflammation is food. Food isn't used calories, it's information, its instructions for your immune system

and every other system in your body. If your diet's high in sugar, refined carbohydrates, ultra-processed food, industrial oils, you're constantly activating these inflammatory pathways. And that lowers your tolerance threshold. On the other hand, when you shift towards an anti-inflammatory dietary pattern, you can calm the immune system remarkably quickly. That means wild-caught fish, rich in omega-3 fats, extra virgin olive oil, leafy greens and colorful

veggies, berries in polyphenol-rich foods. These are all medicines, right? Herbs and spices, like turmeric and ginger, which are anti-inflammatory. And for some people, it's important to temporarily remove common triggers from the diet, like dairy and gluten, because those are the two big ones that drive inflammation and immune activation. And gluten can be a big driver of leaky gut, especially if there's already an underlying gut dysfunction. Even a two or three-week trial of getting off of gluten and dairy can significantly reduce symptoms severity for many patients. Now, it's not that you're allergic to dairy and gluten,

but they do cause gut disruption. They cause inflammation. They're a sensitivity, not necessarily an allergy, but they amplify your immune system's reaction, and you get more seasonal allergies. So when I correct their dietary sensitivities, I always see my patients do so much better on the immune sensitivity from environmental allergies.

So if you want some guidance, you want some support, you want it structure, I got a great program for you. It's called my 10-day detox program. It walks you step by step through how to reduce inflammation and give your immune system a clean slate. It's amazing. When people do this, there's a 70% reduction of all symptoms from all diseases. It's one of the most powerful tools I've ever seen in medicine to do anything for anybody. It's always my first step because if they don't get better after that, then there's usually something deeper I have to find, but it usually gets rid of a lot of problems. So you're not treating the pollen. You're changing the fundamental

terrain by doing that. Second pillar is healing the gut. Your immune system is in your gut. So if your gut lining is compromised, the immune system is just constantly on high alert. So we focus on restoring microbial diversity and strengthening the barrier in the gut, preventing and healing the leaky gut. So how do you do that? Increase fiber diversity, not just more veggies and fruits, but diverse whole foods that help fuel

a healthy microbiome and calm the immune system. You want to use probiotic foods like fermented foods, sourcrow, kimchi, miso, natto, pickles, all that is great. making sure you're having regular bowel movements because if you're constipated, you're just going to recirculate a lot of toxins. That puts an extra load on the system. And in some cases, you want targeted support. Probiotics, glutamine can help. Zinc, vitamin A. Zincarnesine is also great for the gut, collagen, bone broth, all that helps your gut and recalibrates your immune system in your gut. Now, this third pillar is really important because there are several nutrients and plant compounds

that help stabilize mass cells. Those are the cells that really histamine that cause, all the eczema and allergies and everything else. Quercetin is one of my favorites. It's a natural mass cell stabilizer, and it basically comes from plants. It's a nice kind of plant bioflavinoid. Vitamin C also helps degrade histamine. Stinging nettle has anti-histamine effects, and I had a great product I would use for years. It has nettles and quercin. It works really well. Bromoline can reduce inflammation in the nasal passages. That helps. Omega-free fats help prove immune signaling, getting your vitamin E-optimized, also critical for immune regulation. For some people with severe symptoms, short-term strategies like low-histamine diets can also be helpful while you're getting to deeper causes.

Now, these tools work best when combined with gut repair and inflammation reduction, which we've just talked about. So we're supporting the whole system. We're not just blocking it or taking antihistamine. The fourth pillar is getting down on your environmental exposures, right, reducing your environmental load. Because even though pollen isn't the root cause, reducing exposures can lower the burden your immune system is suffering from while you're healing. So what are those strategies to reduce in the environmental load? First of all, use a Hepha filter

in an air filter in your bedroom. I have one in my bedroom. It's really important to keep your air clean because indoor air pollution is a big thing. Shower and change your clothes after being outside. If there's high pollen days, wash your bedding frequently, some people may not use feather pillows if you're allergic. Use saline rinses or a nitty pod to clear the pollen

from your nasal passages. And if your symptoms are year-round or unusually severe, it's important to look at other causes because it's not ceasible, right? It could be mold exposure in your house, it could be poor indoor air quality because that can constantly simulate the immune system, dust mites, all that stuff. All right, so I want to be clear about something. Medication has a place, right? If you're miserable, if you can't sleep, if your eyes are swollen shut and you're missing work, well, it's okay, taking antihistamine. Maybe a nasal steroid can be helpful in the short term. They do reduce suffering, and I'm all about reducing suffering. That matters. Antihistamines block

histamine receptors, nasal steroids, reduce local inflammation. They can be really effective in controlling short-term symptoms. But here's the important distinction. They don't manage the problem. They manage the expression of the problem. They don't deal with the cause. They don't ask why the immune system is overacting in the first place. So if every spinger depend on higher and higher doses,

if your symptoms are lasting longer or if you're developing new sensitivities, that's a clue you better focus on your immune system. The signal is something deeper is driving this imbalance. And that's, my friends, where functional medicine comes in. And we do this all day long at the Ultram Wellness Center in Lenox, my clinic, which I've had for over 20 years. It's not an alternative to convention care, but it's the foundation that you do before you take drugs. And you may not ever need drugs, right? It's a restorative approach.

We're not trying to suppress the immune system, which the drugs do. We're trying to regulate it. Like, how do we rebuild tolerance? How do we calm the inflammation in your body? How do we repair the gut? How do we correct nutrient deficiencies? How do we reduce the total burden from the environment on our immune system? Because when you do that, something really powerful happens.

The immune system becomes less reactive. And often over time, people find they need less medication or lower doses or no medication because their baseline level immune function is better. That's the goal. Not choosing between medication lifestyle, but using medication only when needed, and often it's not needed, and do the deeper work that helps restore your immune system's balance. Because ultimately, we don't just want to block symptoms. We want to build a more balanced, adaptable immune system.

And that is something that your body's absolutely. absolutely capable of doing. Okay, here's three takeaways. As you wrap up, I want to leave you with three simple but powerful takeaways. First, seasonal allergies are not a pollen deficiency. They are a sign of immune imbalance. Pollin is the trigger, but the intensity of your reaction is determined by the internal environment of your body. And that is something you can influence. Second, your gut and your immune system are deeply connected. When the microbiome is disrupted, when the gut's lining is inflamed, when your diet is driving chronic inflammation, your immune system becomes way more reactive.

So calm your gut and you often calm the allergies. It's all connected. Third, you don't have to choose between symptom relief and root cause healing. You know, medication can help. It can have a role when you need a relief. It's okay. But in long-term resilience, you've got to get that by lowering inflammation, by optimizing your nutrient status, by repairing the gut,

by reducing the overall environmental toxin load, by retraining your immune system. That's how you shift from reacting to the world to becoming more tolerant and adaptable within it. You're the sea of your own health. You may not control the pollen count. You may not control the season, but you do have influence over the internal environment of your body,

the choices you make every day, what you eat, how you sleep, how you manage stress, how you support your gut, send powerful signals to your immune systems. Your body's not broken. It's communicating. When you learn to listen and respond to those signals, you shift from feeling a victim of the allergy season

to becoming an active participant in your own healing. That's the functional medicine approach, my friends. And when you address the root causes, you're not just surviving allergy season, you're building a more resilient body for life. Thanks for joining me for office hours. I love diving into these topics with you. Remember, you are the CEO of your own health,

and every choice you make can move you closer to healing and vitality. I want to keep these episodes as relevant and useful as possible, so tell me, what do you want to explore next? What questions are you wrestling with? What breakthroughs are you chasing? Share your ideas in the comments on social media or through the link in the show notes. I'm listening. Until next time, keep taking charge, keep asking questions, and keep showing up for your health. If you have a question about my favorite books, supplements, or recipes, then sign up for my free markspicks newsletter at Dr.heimen.com slash markspicks, where I'll share all of this information with you and so much more. You'll get emails from me every Friday with recommendations on things that have helped

me on my health journey, and I hope they can help you too. Thank you so much again for tuning in. We'll see you next week on the Dr. Hyman Show. If you love this podcast, please share it with someone else you think would also enjoy it. You can find me on all social media channels at Dr. Mark Hyman. Please reach out. I'd love to hear your comments and questions. Don't forget to rate, review, and subscribe to the Dr. Hyman show wherever you get your podcasts. And don't forget to check out my YouTube channel at Dr. Mark Hyman for video versions of this podcast and more. Thank you so much again for tuning in. We'll see you next time on the Dr. Hyman Show.

This podcast is separate from my clinical practice at the Ultra Wellness Center, my work at Cleveland Clinic, and Function Health, where I am chief medical officer. This podcast represents my opinions and my guest's opinions. Neither myself nor the podcast endorses the views or statements of my guests. This podcast is for educational purposes only and is not a substitute for professional care by a doctor or other qualified medical professional.

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