The Dr. Hyman Show - Rethinking ADHD: Root Causes, Real Healing, and the Power of Functional Medicine

Episode Date: July 28, 2025

ADHD and other brain-based conditions such as depression, autism, and even schizophrenia are increasingly understood as inflammatory disorders of the brain—deeply rooted in the complex interplay bet...ween genetics, environment, and lifestyle. Many individuals go undiagnosed for years, internalizing harmful labels like “lazy” or “difficult,” until the weight of unaddressed symptoms finally becomes too much. But there is hope: Functional Medicine offers a radically different approach by uncovering and addressing root causes such as nutritional deficiencies, gut microbiome imbalances, food sensitivities, toxin exposures, and lifestyle factors. Stories of transformation emerge when these root drivers are corrected—children once labeled disruptive begin to thrive, adults regain focus and emotional balance, and families find relief. This emerging paradigm offers not just symptom management but the possibility of genuine healing through personalized, whole-body care. In this episode, I discuss, along with Dr. George Papanicolaou and Dr. Jaquel Patterson, how ADHD and other mental health challenges are often rooted in inflammation and imbalances in the body—and how addressing diet, lifestyle, and root causes can lead to real healing. Dr. Papanicolaou is a graduate of the Philadelphia College of Osteopathic Medicine and is Board Certified in Family Medicine from Abington Memorial Hospital. Over time as the healthcare system made it harder for patients to receive personal care, Dr. Papanicolaou decided a change was needed. He began training in Functional Medicine through the Institute of Functional Medicine. In 2015, he established Cornerstone Personal Health—a practice dedicated entirely to Functional Medicine. In August 2017, I invited Dr. Papanicolaou to join The UltraWellness Center and we’ve been successfully helping people together ever since. Dr. Jaquel Patterson is a nationally recognized naturopathic physician, success coach, three-time Amazon bestselling author, and Forbes contributor. She owns a successful medical practice, Fairfield Family Health in Connecticut, and brings over 16 years of clinical experience, specializing in Lyme disease, autoimmune conditions, integrative psychiatry, and environmental medicine. A sought-after speaker, Dr. Patterson has been featured in USA Today, New York Magazine, and Forbes, and on CBS, Fox, NBC, and ABC. She’s the past president of the American Association of Naturopathic Physicians and currently serves on the board of the American Academy of Environmental Medicine. Certified by the Institute for Functional Medicine (IFM), she’s also completed a fellowship in functional medicine with a focus on psychiatry and ADD/ADHD. In addition to her naturopathic medical degree, Dr. Patterson holds an MBA in Healthcare Management from Quinnipiac University and an undergraduate degree from Cornell University. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%. Full-length episodes can be found here:Why ADHD Is Not A Psychiatric Disorder Or Brain Disease What’s Fueling Our Mental Health Crisis and How Can We Fix it? 7 Strategies To Address ADHD

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Starting point is 00:00:00 Coming up on this episode of the Dr. Hyman show. What we now know is that ADD, autism, depression, dementia, Parkinson's disease, these are inflammatory diseases of the brain. Even schizophrenia, bipolar disease, all these are inflammatory brain disorders. If you're living on caffeine, constantly tired, and feel like your stress is stuck on high, there's a good chance you're low in magnesium. Magnesium is critical for turning food into energy, calming your nervous system, helping you sleep, and regulating your mood.
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Starting point is 00:01:41 Just open Apple podcasts and tap try free to start your seven day free trial. The thing with ADHD, first off and foremost, is it's primarily been looked at as a medical model. In the psychiatric world, it's a medical model. It's sometimes seen more as a behavioral issue and it's treated with medication. It's a brain disease. It's a brain disease. And as if you said before, the brain, it's really, it's a body disease that affects the brain. Yeah. Okay.
Starting point is 00:02:13 And you've said that. Now in ADHD, there are some issues around the brain itself that make adults and children more susceptible to this inattention or their ability to fail at executive functioning. And the other piece is the self-regulation piece. And so, you have this combination ADHD where you have self-regulation as an issue and you have the executive functions of an issue. And now it's been given this label, attention deficit hyperactivity disorder. And that's just the cluster of symptoms that everybody experiences to some degree in their lifetime. Now, there's one kid in
Starting point is 00:02:52 kindergarten that maybe he didn't pay attention once in his lifetime. He's a spy, I don't know what he's doing, but he's doing something like where you have to pay attention all the time. And then there's the other person, they're so disabled by their ADHD, it's hard for them to work. It's hard for them to maintain relationship and even marriages. And then everybody else falls somewhere in between. And I think it's important to understand that piece, that it's a medical model and that when we see kids and adults, the other piece is that more and more adults are being diagnosed and at least 4% of adults are found to have ADHD and maybe even more.
Starting point is 00:03:35 You know, I think we'll find out there's more as we go on. That they carry on the traits of the ADHD, they go undiagnosed and then as they're adults, it becomes more prevalent as life piles up and their compensatory mechanisms become overwhelmed. All of a sudden, they're getting older and they're not eating right and they're not exercising. Their ADHD becomes more prominent and then they come seeking help. And on top of that, we live in an ADHD culture where we're all driven to consume huge amounts of information by the addictive nature of social media and the internet. And it literally is taking people who are not even ADHD and making them like that, where they're hooked on their
Starting point is 00:04:18 phones and they're constantly distracted and they're constantly getting the dopamine hit. And it's magnifying it. And if you have ADHD, it's even worse. Yeah. And here's how they come to us. They come to us as families, as a mom or dad bringing a kid in and they're discouraged, they're frustrated. The child is feeling left out. He's feeling alone because he's being labeled as a behavior disorder.
Starting point is 00:04:43 He is unable to keep up in the regular curriculum in the school where you have to sit and get and he can't sit and get, right? He has to move around. He has to see pictures. He has to have creative illustrations or she, you know, and that's how they come to us and they've heard, oh, Johnny's so smart if you don't even work harder, you know? Suzy,'d only work harder. You know, um, Susie, if she would just, you know, apply herself, you know, I sometimes I think she's a little bit lazy. Right. And they start to hear that language and then they start to inculcate that as their own identity. Right. And, and that becomes a negative self-talk that becomes
Starting point is 00:05:21 discouragement. That becomes hopelessness for some people as time goes on. I mean it's seen as a psychiatric disorder by Psychiatrist yeah, and and maybe it isn't really a psychiatric disorder It's not and it's not most psychiatric disorders are not psychiatric disorders. That's why I wrote the book You even said in that book right right because it's the body affects the brain and the brain affects the body the mind affects the body But the body affects the mind. Yeah, and I think the cure the body affects the brain and the brain affects the body, the mind affects the body but the body affects the mind. And I think the cure for brain disorders is often outside the brain and I think that's what we're talking about here.
Starting point is 00:05:50 Now it's actually becoming part of conventional medicine. I recently interviewed for our podcast an expert in nutritional psychiatry and the microbiome and psychiatry from Harvard. Another one who was in Stanford studying metabolic psychiatry. So we now know that there are so many factors influencing our brain function that have been ignored by psychiatrists and they're using psychiatric drugs like stimulants, like Ritalin to help people focus. But it's just like pouring, you know, water on a fire with somebody else
Starting point is 00:06:27 pouring gasoline on it at the same time, you have to get to the root causes. Right. And which, yeah, and I know we're gonna get to the root causes but one of the things I just really wanted to mention is in that discouragement that parents come and they say, you know, they're worried about their child's performance and even adults who now have piled up failure after failure after failure because of their inability to really deal with their ADHD and they didn't even know they had it, right? I had a patient, she was 40 years old. She came to me because she saw one of my nurse practitioners and my nurse practitioner said
Starting point is 00:07:01 she wants a refill on her Ativan but she, you know, I'm uncomfortable giving it to her. And because she was a new nurse practitioner, I said, well, let me see the case. I saw the name of the patient. I saw that they were coming to get their Ativan again and they had a gap of using it. So, I said, you know what? Schedule her with me. And she said, you know, I use it because I get overwhelmed. I said, what do you mean overwhelmed?
Starting point is 00:07:23 What's an anxiety medication? She takes it because she gets anxious and overwhelmed. I said, well, what do you mean? Well, I get overwhelmed. I said, what do you mean overwhelmed? So, it's an anxiety medication. She takes it because she gets anxious and overwhelmed. I said, well, what do you mean? Well, I get anxious. Well, what do you mean by anxious? I get overwhelmed. What does overwhelmed mean? And she started to describe all the symptoms of ADHD, right?
Starting point is 00:07:36 And she's a teacher. She was 40 years old. I took her through the DSM-4 classification and then she went on to get a diagnosis. That's a psychiatric manual for how we label people. How we label people. With different mental illnesses. I used it. By symptoms.
Starting point is 00:07:51 I did use it. I'm sorry, but I had to. It's good to sort of get a label, but I always say just cause you have a label, it doesn't mean they know what's wrong with you. You don't know the cause of your depression or ADD or whatever is going on. So I told her, you know, we did it. I said, you have ADHD. She was devastated. She was truly devastated her, you know, we did it and I said, you have ADHD. She was devastated. She was truly devastated and you know, she came back in tears because one, all the regrets, like why didn't I get diagnosed sooner?
Starting point is 00:08:13 And then the denial, maybe I don't really have it, maybe there's something else wrong that can be fixed easier. Anyhow, it's like now eight years later and I run into her because we're friends and she got an ADHD coach. She did take Adderall for a short period of time. I got her to work on her nutrition, so forth and so she's doing amazingly well. But the point I want to make is that ADHD can be a really devastating experience and one of the things that I like to do when I'm working with my patients,
Starting point is 00:08:47 this is the first thing we do. We've got to normalize it. We got to let you know everything's going to be okay. Well, that's right. There's a stigma, George, around mental illness. And that's really why I wrote the book, Ultramind Solution, because it's very clear to me seeing patients who I would treat their biology and their psychology would get better. And I wasn't treating their brain, I was treating their body and I would notice the quote side effects of their ADD going away, their autism getting better, their depression going away,
Starting point is 00:09:18 their panic attacks going away. I'm like, what is going on here? So that really through the lens of functional medicine, what we do here at the Ultra Wellness Center in Lenox, Massachusetts, where we practice, is we go deep into these root causes. So with ADHD, what are the things that are the most common drivers? Because it's not a Ritalin deficiency, as we said, right? It's something else. What are we seeing in these patients that we find that then we can treat and help them get better?
Starting point is 00:09:45 I start with the understanding that there are some structural differences in the brains of a person with AD. There's a predisposition. Yep, there's a predisposition. It's genetic, it's physiologic, so, you can't ignore that starting point. Now that's not the first, you know, so that's my first line of thinking and I know that I'm going to find out what that is. It's important to remember people that genes load the gun but the environment pulls the trigger. Exactly.
Starting point is 00:10:21 So, you might have a predisposition, it doesn't mean you're predestined to have the problem. Exactly. And that's exactly right, Mark. That's the point. And that's where I go next is, I know the predisposition is there and I have tests that I can figure out what some of those predispositions are actually expressing themselves in that child or adult and I will address them. But I also, as you just pointed out, is I go back to the environmental pieces first. Because those I can start working on at the very first visit. You can modify. Modify the very first visit without having to do any tests.
Starting point is 00:10:52 And that is to go through lifestyle. And where's the first lifestyle piece I go to? It's nutrition, right? And because the nutrition does a couple things. There's the nutrition, the actual macro, micronutrients and minerals and phytonutrients that the child needs that they might not be getting. And then there's the impact that that diet he's on is having on his body, particularly on the gut microbiome. On the bad diet.
Starting point is 00:11:21 Right. That bad diet, right? Which is filled with all the things that you talk about all the time, the high fructose corn syrup, the GMOs, the hormones, the pesticides. The additives and colors and dyes. Those chemicals have been linked in research to ADHD issues. Absolutely. Really clearly.
Starting point is 00:11:39 Yeah. And there's a diet, the fine gold diet is based on removing those from the diet. So, I can modify that right off the get-go and I can get them to start to think about how to change that child's diet and simply remove some things, right? And add some things in their place to start moving them in the right direction. And the diet you're talking about that they're getting usually is an inflammatory diet. Yes. And what's fascinating to me is we start to look at the research on all these brain issues, whether it's autism or ADHD or Alzheimer's or depression, there are inflammation in the
Starting point is 00:12:14 brain. Yeah. We never knew that before. Yeah. So, do you take an Advil if you have depression or if you have ADD? No, you have to figure out why there's inflammation in the brain and that's what functional medicine does. It's a methodology to get to the root cause of whatever it is and in this case, it's inflammation
Starting point is 00:12:31 in the brain and all these kids often have other inflammatory issues too and you have a case and I want to share a case where we talk about this. But how do we sort of begin to tease apart what aspects of the diet are the most important in these kids? Stan? First, I interview, like I ask. I know to tease it apart, you have to ask like okay, what mom? Marshall?
Starting point is 00:12:52 What are you eating? Or not eating? Stan? You know, and I'll ask them, right? And as soon as I asked a child what they eat, here's what happens, I just picked this up. Mom's holding a folder or a newspaper or something and as I asked a child what they're going to eat, I see this. Okay? I usually see she's gonna hide because she knows what's gonna come out, right? We're gonna hear about Lucky Charms and we're gonna hear about Hot Pockets and we're gonna hear about, you know,
Starting point is 00:13:16 the Gatorade and-... Flaming hot chips. And she feeds the child that because that's what the child wants to eat. And because they can't self-regulate, she knows that there's going to be, you know, there's hell to pay when you're not giving them what they want. So yeah, so first off, you tease it out by doing a three-day diet history, talking to the mom, talking to the child. And once you begin to tease that out, then you can get an understanding of what you need to add back in. And most of the time it's like everything.
Starting point is 00:13:48 Yeah. You know, and... We also do food sensitivity testing, including gluten and dairy, which often causes inflammation in the brain for these kids, right? Yeah. You know, I don't know when you want me to talk about the testing piece, but the thing I want to say about the gut microbiome in your diet is that inflammatory diet remember, you don't have to remember but for our listeners that the gut microbiome does things for us. It's like another organ.
Starting point is 00:14:14 And so 70% of our serotonin resides in the gastrointestinal tract. Like a second brain. Right, second brain. 30% of our dopamine resides in theestinal tract. Like a second brain. Right, a second brain. 30% of our dopamine resides in the intestinal tract. When you're eating a bad diet and you're shifting the microbiome, you're shifting the balance of good bacteria and bad bacteria, you're now going to create an environment where a child cannot produce some of those neurotransmitters. You're going to create an environment where they're not breaking down their food completely.
Starting point is 00:14:49 Because of the inflammation, you could be getting something called leaky gut and that dysbiosis, that leaky gut, that leads to a lack of absorption of some really important nutrients. That begins to have a big effect. So, now they're not absorbing their magnesium. Now they're letting too much copper in and not enough zinc. Now you're not getting enough iron. And we know that if you're anemic and you don't have enough iron, you're going to not be able to concentrate well. That's the real important impact of your diet. It's not just, oh, sugar is bad for them. Well, what's it doing
Starting point is 00:15:26 to you know, you may notice that the microbiome. We got to fix that. And that's why I said, I know what the predisposition is, but the first place we're going to go is to the lifestyle and what because that lifestyle is affecting the most important thing and that's the gut. Yeah, nutrition is so huge and we see this with these kids. They have poor quality nutrition. They're eating a lot of processed food. They're not getting the good nutrients they need. They're eating foods that are inflammatory. They're having gluten and dairy often, which can be very neurotoxic for some kids. They're eating additives and chemicals in their food that can trigger hyperactivity. And so there's this whole range of food interventions that have been shown to be very effective for these because even removing food sensitivities
Starting point is 00:16:06 That's one study published in the uk So there's a lot of literature on this, but it's not it's not something that you get when you go to the psychiatrist It's not mainstream about no, they don't talk about this. So so we're looking at the role of nutrition Yeah, nutritional deficiencies food sensitivities and lack of the right nutrients Yes, what are the other things we should think about the gut you said the the gut plays a huge role, right? Yeah. Yeah, yeah leaky gut Yeah, everything I just mentioned, you know with the leaky gut the alterations the microbiome You're going to have less serotonin made less dopamine made You're not going to get the nutrients that we just talked about and so that we look there and we can do tests to determine
Starting point is 00:16:44 We have very sensitive tests that can look at, we do organic acid tests that can look at amino acid levels, which are the precursors for making your neurotransmitters. So that if you're not eating enough protein, which kids don't eat enough protein, you're not eating enough protein, and then you have already disordered your microbiome, which includes your gastric acids, which includes your pancreatic acids. Those are very important for breaking down your proteins, your carbohydrates, and your fats. You get all the nutrients you need. So, we need to make sure that they're, you know, if that's not happening, they're not getting their amino acids, then they're not going to make these neurotransmitters. We can measure that using organic acids. We can look at carbohydrate metabolism that's important in energy production, energy that's needed for the body to work, particularly the brain since it has the most mitochondria
Starting point is 00:17:37 in the entire body because it needs the most energy. If that brain's not making energy because you're not getting the appropriate amounts and the types of carbohydrates, that child is not going to do well. Yeah. And we can determine that on the organic acids or an ion profile. Yeah. These are kind of tests you don't normally get at a regular doctor. No. And these tests tell us about things like mitochondria. You mentioned mitochondria,
Starting point is 00:18:01 I just want to sort of loop back on this because there's a woman named Suzanne Goh, a pediatric neurologist, went to Harvard, Oxford and studies autism and she's found in these autistic kids, there's a subset of these kids that have impaired mitochondrial function in their brain and it's an energy deficit which can cause these neurologic symptoms. And so, she provides the substrates or the basic building blocks for making energy in these kids that are supplements like coq10 and carnitine and other nutrients that are so important for building energy in the system. So, we sometimes find this in these kids, they have energy issues.
Starting point is 00:18:38 You know, we've seen that with our autistic kids that when we give them, you know, those, we give them amino acids. When we give them methylcobalamin, which is a basic nutrient, yeah, you see changes in how they- Dr. Justin Marchegiani Dramatic changes. Stan McYver Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani
Starting point is 00:18:57 Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani Dr. Justin Marchegiani these kids sometimes, right? Talk about toxins and mental health and particularly ADHD.
Starting point is 00:19:05 Right. So, the toxins that we look for the most and they're tested for in schools as part of your- In lead. Lead. There you go, got lead. So, we have lead. We also have mercury and we have arsenic. Yeah. Those are three very common heavy metals that you're going to find in your environment. So, those each one of them are going to be able to block the energy producing pathways in cells. They're also going to limit the neuro transmitter metabolism, the metabolism neurotransmitters
Starting point is 00:19:44 in the brain directly. They're directly neurotoxic and they also have effects on the body's ability to make energy in their mitochondria. So we test for heavy metals in kids all the time and why do kids have that and why do we find that? Because I tell people, it's not a matter of whether you're toxic. It's not a matter of whether you have heavy metals, it's how many do you have, right? And how much. And that's going to be a product of several things. One, we go back to genetics. You just may not be a good detoxer, right?
Starting point is 00:20:16 You may have snips, which are single nucleotide polymorphisms. Those are like one single nucleotide change in the blueprint that makes the protein. And if that is off, then that protein is not going to work correctly. Well, if your detox proteins and enzymes are not working, you just don't detox that well. And we can determine that. And then we can determine what your lead levels are and then we have ways that we can bring those down. And it's so common, you know, I remember this kid I had who was like 10, 11 years old, just a terror, ADD, getting kicked out of class, disruptive behavior issues
Starting point is 00:20:53 and the mother was just desperate. I wasn't in your class. She was a young mother but she was very smart and she kind of came to us and it turned out school was across the street from a cement plant and the cement plant burns coal and coal releases mercury and lead and every day they go in the parking lot at the end of the day the cars are just dusted with this ash from the cement plant and the kids were playing in the playground with the cement plant and I tested him and he had very high levels of heavy metals and we detoxified him, we fixed his metabolic pathways and this kid got better.
Starting point is 00:21:27 So, you know, it's not that every kid with ADD has lead or mercury. It's just one of the things to think about. And just like I was saying, with functional medicine, just because you know the name of the disease doesn't mean you know what's wrong with you, right? ADD can be many, many things and many, many factors. It can be gluten, it can be metals, it can be nutritional deficiency, it can be magnesium issues, it can be, you know, your gut microbiome, it can be gluten, it can be metals, it can be nutritional deficiency, it can be magnesium issues, it can be your gut microbiome, it can be gluten. You don't need more caffeine or another stress supplement.
Starting point is 00:21:53 You might just need more magnesium. Magnesium supports sleep, mood, energy, and focus, but most of us are missing it. That's why I recommend magnesium breakthrough by Bioptimizers. It combines seven forms of magnesium for results you can feel in your mood, sleep, focus and more. Try it now for 10% at Bioptimizers.com slash Hymen. Your body will feel the difference. When this state of inflammation is going on in the brain, what's actually happening? How do neurotransmitters get affected? What's happening with the brain that causes all these psychiatric symptoms?
Starting point is 00:22:32 So you'll actually see altering of, for example, NMDA receptors being impacted, which can cause that issue with glutamate, and then there's this altered, you should have an altered balance of, for example, GABA, which is more relaxing, an inhibitory neurotransmitter with glutamate. And then there's this altered, you should have an altered balance of, for example, GABA, which is more relaxing, an inhibitory neurotransmitter versus glutamate, which is triggering.
Starting point is 00:22:50 So if you're having those ratios change, you're going more into a state that's excitatory, which is gonna cause anxiety, depression. You'll also see some of those protective cytokines like IL-10, which are gonna help with inflammation, will go down because you're gonna have more of the pro-inflammation. And that is actually one of the big factors feeding into things like dopamine, which make you feel good.
Starting point is 00:23:15 And dopamine is one of the ones that can go lower for somebody that's depressed. And when you're inflamed, your dopamine gets lower. And when you're inflamed, exactly, it'll go lower as those inflammatory markers increase up. So it kind of shifts the whole balance. So we need a little bit of each one. So it's not, I always tell people, it's like, we do want a little bit,
Starting point is 00:23:31 we do want some glutamine, we want those things, but it's what that balance is. And what happens is with inflammation, it changes not only causing the direct damage to the area of the body, but also changing the neurotransmitter, the ratios, which will put you more in a state that is going to be more imbalanced. Yeah. Yeah, I think that's right. And I think we end up causing trouble with the overproduction
Starting point is 00:23:57 of excitatory neurotransmitters that stimulate pathways, like you mentioned, or the lack of that stimulate pathways like you mentioned in New York or the lack of neurotransmitters that help us with mood like dopamine or serotonin, right? And one of the tests we do in functional medicine is called an organic acid urine test, which seems like a crazy thing to do is check your urine if you're having psychiatric issues. But in my patients is one of the most important tests
Starting point is 00:24:21 that I do and it's something we used to do only for people with inherited metabolic disorders. And you can get it a lot, but it's really about the more subtle changes that occur in the biomarkers that relate to what's going on in your body. And one of the things we see is an increase in chimeric acid,
Starting point is 00:24:39 which is a sort of a marker of a- Pathway that increases up in terms of inflammation and is also a marker looked at when we're looking at neuroinflammation. And it changes tryptophan and these are all precursors for things like serotonin. So, chironin pathway is also a marker of concern when it comes to neuroinflammation.
Starting point is 00:24:57 Yeah, so you can see like that sort of a sign of B6 to functional efficiency. And that is B6 is required to convert tryptophan from a diet into five-hydroxy tryptophan in serotonin. And then when that's not working or when there's inflammation, it also blocks an enzyme. Can you talk about that enzyme, the IDO enzyme? Yeah. So it blocks the enzyme that's going to help with, it's causing more of the increased metabolism to, like you said, in terms of 5-HIA, in terms of serotonin.
Starting point is 00:25:26 So it's going to impact that pathway directly, which is going to be increasing up inflammation. But then again, the ones that are helping with things like anxiety are now getting blunted or impacted negatively, where it's actually interfering with the production of it. And one of the biomarkers we see on the organic acids is quinolidic acid. A lot of big words I know out there, but this is a biomarker you can check in your urine that indicates that the serotonin is getting shunted down a different pathway,
Starting point is 00:25:55 which then leads to more anxiety, more depression. And you're getting this byproduct, which is highly inflammatory in and of itself. And it's a toxic kind of metabolite in the brain. And you can see it in the urine. And I can tell when my patients brains are inflamed, they have high levels of this, whether it's a neurodegenerative disease, or there's ADD or autism or or depression. And so, you know, we can start to understand the biochemistry of this and the neurobiology of this in ways that allow us to actually directly intervene with therapies that can fix these problems, right? Exactly, and the chironin pathway is like kind of
Starting point is 00:26:28 the precursor to all of those ones that you just discussed. And so also the great thing with like the OAT test, which you mentioned, there's also a section that tests for catecholamines and those are all connected with norepinephrine, epinephrine, it checks for like HVA and all of those pieces in terms of your dopamine and also even like fatty acid metabolism because we know fatty acids help to drop down CRP
Starting point is 00:26:53 which we're talking about with inflammation. And so if you don't have a good balance of omega-3, omega-6, omega-9, you're gonna be again more pro-inflamm, you know, pro-inflamed, which also is gonna negatively impact your mental state. So, and your physical body, obviously, but there's been tons of studies on just omegas as well, just for the mental health.
Starting point is 00:27:11 And part of it is that down regulation of decreasing of the CRP levels. So you know, one of the things that I have been reading about, which I find fascinating, and it sort of kind of, kind of comports with what we're seeing in our society, which is this increase in dysregulated social behavior, right? Aggression, divisiveness, friends can't talk to each other anymore. Families are breaking up over political issues. There's just, whatever's going on,
Starting point is 00:27:37 there's just something happening where our social cohesion is breaking down. I mean, I think most Americans are pretty middle of the road and are not on the extremes, but the extremes, but the extremes are what we see and hear about. But there is still a level of real divisiveness in our society and a real level of like increased
Starting point is 00:27:53 in aggression and school shootings and violence. And now, I mean, we see it every day and I become almost immune to these stories, which, you know, if you ever had had one, it would have been a big deal. And we didn't have this when I was growing up. It wasn't like every day or every week, there's a new shooting in some school.
Starting point is 00:28:11 And the level of just sort of oppositional behavior and anger and hostility. And I mean, it's like I have a social media account. I just like sometimes I put stuff up that's sort of benign and you get like a litany of hatred. And I'm like, what is going on out there? And why are people acting like this? And part of it's, you know, they can hide behind
Starting point is 00:28:27 their social media handle or whatever, but I do think there's something fundamental happening to the brain. And I mentioned this before in the podcast, but when I was writing my book about the food system and the way our food is affecting us, I wrote a lot about the social aspects of it. And particularly, so studies that I came across
Starting point is 00:28:44 around prisoners who when fed a healthy diet would decrease their violent crime in prisons by 56%. And I think a multivitamin reduced it by 80%. And in juvenile detention centers, when kids were fed healthy diets versus the crab that they were eating, the violent crime went down by 97%. The recent restraints went down by 75%. Suicide, which you mentioned, went down 100%
Starting point is 00:29:09 in an age group of teenage boys, which is the third leading cause of death. And that's just simply cleaning up the diet, which is moving them from an inflammatory to an anti-inflammatory diet. So I have this theory, which is that a lot of our social disruption right now is really related to some level of neuroinflammation.
Starting point is 00:29:26 And when I was sort of reviewing your work, you were talking a lot about what happens to the adult in the room, which is sort of the person that knows we shouldn't go punch somebody in the nose, right, the one that we want to. That's in charge, yeah. The adult in the room gets disconnected from the ancient limbic reptile brain.
Starting point is 00:29:44 And there's this weird disconnection that happens for the adult is gone. And so it's like, we call it the amygdala hijack, which is the hijack of our behavior and our thoughts by this ancient part of our brain, which is all about survival, fight or flight, right? So can you talk about the science around this phenomena that we're seeing around neuroinflammation
Starting point is 00:30:04 affecting the connection between the kind of grownup mature person who's supposed to know how to conduct themselves socially and in life with the ancient part of our brain that just would kill anybody or do a stupid shit. So what is the science behind that? Can you unpack that? And also the trauma, like when you look at kids,
Starting point is 00:30:25 they said have shown the trauma from all these events, like that you were talking about. There's just long-term, we don't even know yet, longer-term issues with things like anxiety and depression as a result of the trauma that's happening during that time. Yeah, there's epigenetic. Exactly, there's complete changes. So we have what's called the prefrontal cortex that develops for kids up until 26 years of
Starting point is 00:30:49 age. We have what's called the amygdala. That's why they don't rent cars. That's why the car rental companies don't rent cars to anybody over under 25. Because of that reason. Because they know that the brain is not fully developed. The grown up in the room is not in the car. Is not actually going to be the one driving, right?
Starting point is 00:31:04 So we have the hippocampus, which is like for memory. And those actually both take a hit for anxiety and depression, which makes sense, because you look when somebody has like significant depression or anxiety, you'll see like a lot of memory issues like flightiness for people, anxiety, brain fog, forgetfulness. Yeah, those even cause pseudo dementia.
Starting point is 00:31:23 People get older, they get pseudo dementia and depression. Exactly. And actually, even the risk of dementia is up higher for people with mental health issues as well, likely because of the neuroinflammation. So you'll see those areas, amygdala is more connected with anxiety, and that's what controls emotions and that piece with the nine-year-old
Starting point is 00:31:42 driving the bus versus the adult driving the bus. And so if you're constantly getting taxed with that in everyday day the nine-year-old driving the bus versus, you know, the adult driving the bus. And so if you're constantly getting taxed with that and everyday day-to-day trauma, that is going to be more dysregulated. I mean, they've had studies that show women passing, like in terms of being anxious during pregnancy having an impact on their babies that are born, the baby, the child having more anxiety and things like that. So the development of the prefrontal cortex, which is like impulse, impulses can develop up until 26 years of age, other areas of the brain that get affected, amygdala, like I mentioned, hippocampus,
Starting point is 00:32:18 and other centers that help to regulate like our emotions. So if there's constant inflammation on those areas or constant stress, which causes a dysregulation of cortisol levels, those will all, will could potentially impact those longterm too as well. So do you think like my theory is right that a lot of the social discord is happening as a result of brain inflammation
Starting point is 00:32:42 is caused by all the factors we talked about? Yeah, I mean, they have tons of studies on technology's impact on dopamine and that every time you have like a hit, like even a ring on your cell phone or, you know, did you do it like when you get your text, you get a dopamine hit for that. So one of the pieces is the more and more you have it,
Starting point is 00:32:59 the more of a result like you're having less your body is constantly needed to push out dopamine for everything with technology. One example I had, it was great because I did a urinary test and I was trying to get the person, I was actually working with someone that I didn't know was a big gamer. And so we did the test and at the evening,
Starting point is 00:33:19 the cortisol was like, was the same that you would have in the morning to wake up, because your cortisol should be higher in the morning to wake up. And low at night. And then I said, what were you... And I knew right away, I'm like, were you playing, like, video games? And she looked and was like, how did you know?
Starting point is 00:33:33 I'm like, this number, there's just a lot of, like, hyperactivity. Her dopamine levels were high, norepinephrine, epinephrine. Um, cortisol was through the roof. So, of course, she's gonna have sleep issues, which she was having. Um, so you'll see that, too. I mean, a lot of course she's gonna have sleep issues, which she was having. So you'll see that too. I mean, a lot of young people that are also on technology,
Starting point is 00:33:49 they're staying up till late at night, as you know, and it interrupts their sleep. And if they're not getting good quality sleep, of course they're not gonna be able to focus in class. Of course they're not gonna be able to emotionally regulate as well. So all of those things have these kind of added effects that can cause issues, but
Starting point is 00:34:06 definitely technology with dopamine and as much as the parent can work with reducing it in small bits. I don't try to say stop completely. I say let's cut 15 minutes, you know, at a time so it doesn't seem as significant. But that's what the great thing about tests are because you can actually see and show and demonstrate, and then it's easier to get people to say, oh, okay, this is why. It's true. I mean, I had a nephew
Starting point is 00:34:30 who was a super addicted gamer, and, you know, just didn't have a life other than gaming. And long story short, he lived with me for a while, and I took it all away. I literally just hit it. And it was literally like watching someone go through a hair withdrawal. Like he went ballistic. And I was like, wow, this is like a highly addictive thing.
Starting point is 00:34:53 So I think that, and he had ADHD and it just made it worse. It made it a lot worse. And I think we have this incredible moment happening in the field of psychiatry where we're beginning to understand the brain in mental health, not just the mind. And talk therapy can be helpful. Sometimes psychiatric medication can be helpful,
Starting point is 00:35:12 but it's a pretty limited tool set. And now we have a whole new set of tools. So when you see sort of someone come in and they could have anything, right? Anything from schizophrenia to bipolar disease, to depression. There's a process you go through to try to figure things out. Like, you know, because depression is not
Starting point is 00:35:33 a Prozac deficiency, right? Exactly. And it's kind of how we treat it, right? I call it the naming, blaming, and taming game. This came from my mentor, Sid Baker. He says, we name the disease by the symptoms and then we blame the name for the cause and then we tame it with a drug.
Starting point is 00:35:48 So we say, oh, the reason you're hopeless and helpless and have no interest in life and can't sleep and have no interest in sex and don't have an appetite and you feel sad and you wanna cry all the time is because you're depressed. That's what's causing your symptoms. Well, no, that's just the name that we give to people who share those symptoms.
Starting point is 00:36:02 The cause could be you're eating gluten and that's causing brain inflammation or you're having a bad diet and had reflux because you eat too many fried foods and end up on an acid blocker for 10 years which depletes your B12 and zinc and magnesium or because you maybe have no vitamin D and that causes depression.
Starting point is 00:36:20 And you're looking to see like, where does it land? I always say that for autoimmune conditions. It's like, to me, it's all the same thing. There's different names, you know? But it's like, where does it, I say, like land. And then that's why people have like three autoimmune conditions. And I'm like, is it really three different ones
Starting point is 00:36:34 or is their system just attacking itself and it's finding their weakness? Yeah. It's like aspen trees, you know? Like they all look like separate trees, but they're all one underneath. Exactly, still the same. And so that's kind of how most diseases are.
Starting point is 00:36:47 They're not comorbidities or not things that just happen to be randomly showing up. I'm like, you know, this kid that I was mentioning before I had ADD had like 12 different diagnoses, like, and was on seven different medications and was seeing five or six different specialists. And no one asks, how are all these things connected? Like, at least he has-
Starting point is 00:37:09 And when did it start and how did it start and things like that. The beauty is then we can start to actually think differently about how to approach these problems and start to think about the common root causes and how to one, do the diagnostic evaluation, which can pick a lot of these things up, and also the treatment strategies.
Starting point is 00:37:27 And it can be something simple, like I mentioned with depression, I mean, it can be a B vitamin deficiency. And I was writing my book, and I think I was talking to somebody on the phone about it or whatever, and he heard me, we were talking, it was like I was fixing my TV in my office, and he had happened to be working when he was there.
Starting point is 00:37:42 And he's like, oh yeah, I was listening to what you're saying. And I was really severely depressed. And he's like, oh yeah, I was listening to what you're saying. And you know, I was really severely depressed. And then I took, you know, these B vitamins, like B6, folate, and B12, and it went away. And actually methylfolate or dephlin is actually a prescription drug, quote, drug, which is an activated form of folate that psychiatrists use for treating depression.
Starting point is 00:38:02 But it's all like kind of this, like one thing at a time, it's like still the drug model. It's not really a holistic view of the body as a system. So, Dr. Hanson, when someone comes to you, see you, and they're suffering from, whether it's depression or whether it's more PTSD, or maybe they're having some psychotic kind of borderline issues or bipolar,
Starting point is 00:38:24 where do you start and then how do you kind of find the things that are driving the problem? And then what are the sort of steps you take to help resolve that? I think my most important thing is to also meet people like where they're at. So initially I'm trying to do extensive use. I just want people to do what I wanna do.
Starting point is 00:38:42 I know how to get you better. That would be a lot easier. Do what I say, you don't get to choose. That would make life a lot easier, right? I'm pretty actually convincing because I said, look, let's try this for 10 days. That's what I say. I'm like, let's try removing this food for a week
Starting point is 00:38:56 and see how you feel. And then people come back and they're like, oh yeah, it worked. So I think the one thing when people see like naturopathic doctors, functional medicine doctors, they're gonna get tons of lab work done initially. That's always really important to me in the assessment because I'm gonna look at environmental factors
Starting point is 00:39:10 like I mentioned, like metal, lead. You mentioned when you were saying about juvenile delinquency of like changing food. There are studies that even show there's a higher rates of schizophrenia after the age of 14 being, actually juvenile delinquency and schizophrenia if they've drank from like private well water
Starting point is 00:39:29 and poor water. So even when you're talking about food, it's like what is the quality of their water? What is their environment by way of pollution? I've had children that we've had. You've had some parasites who've had it. Exactly, even parasites where they've had ADHD and then they found that there was a lot of mold
Starting point is 00:39:44 in their bedroom and they removed that and all the kids symptoms were gone. Or I've had even adults that were exhausted and then when I did the assessment, I find out they drink four ounces of water and I'm like, okay, if you try to drink water and they come back, they're like, I feel completely new. Like how's your body eliminating toxins?
Starting point is 00:40:00 So that's when I said meeting people where they're at because there could be just basic things that people aren't even aware of. But typically with assessments, it's gonna include like their metals, it's gonna include things like you said, like O test, I'm gonna look at other infections, organic acid tests I'm gonna look at.
Starting point is 00:40:14 And especially if someone's like that rule of like, ever since of like, I got sick at this time, and then ever since then this happened. For women, a lot of times hormones, so like after they have a baby, after they have a kid, you'll see those hormones drop down, which hormones actually are like estrogen, can be if it's in a high amount more pro-inflammatory
Starting point is 00:40:35 and testosterone more anti-inflammatory. So you'll see when there's a shift of that or the cycle or perimenopause, autoimmune conditions will go up too. So I'm looking to see like what that pattern is of like when it actually became dysregulated and getting as much like laboratory assessment, but like really having deep in-depth conversations
Starting point is 00:40:55 of their story. Because you can, oh yeah, I was fine until I moved in that house. Exactly. Tell me about that house. Well, you know, it was okay, but it was a little damp basement or had like, I think we had mold in the bathroom, something and you get these clues. And I think, you know, it was okay, but it was a little damp basement or it had like, I think we had mold in the bathroom,
Starting point is 00:41:05 something and you get these clues. And I think, you know, in traditional medicine, we sort of ignore most of those clues. Like, you know, your psychiatrist didn't ask about mold or how much tuna you ate or, you know, right? Or were you inflamed or? Right, right, right. Yeah, no, that's true.
Starting point is 00:41:18 And I, you know, I think you mentioned lab testing. You know, I co-founded a company called Function Health and we do a full panel of lab testing and we look at a lot of things that do affect psychiatric health from your nutritional levels of vitamin D of Evaluation of the B vitamins from a cysteine and Methamolonic acid which are ways of looking at B12, folate and B6. We look at red cell magnesium We look at zinc. We look at also other factors like metabolic health, insulin resistance, which can affect depression
Starting point is 00:41:44 Look at sex hormones can affect mood. We look at also other factors like metabolic health, insulin resistance, which can affect depression. Look at sex hormones can affect mood. We look at heavy metals. So we got to really, and we look at inflammation. I don't know if it's mind blowing to me, but in our population, we've done 5 million biomarkers on over 40,000 people and 46% have high CRPs. 30% have high ANA. 67% have a nutritional deficiency,
Starting point is 00:42:07 whether it's iron, like you mentioned, or homocysteine problems, or magnesium, or omega-3s. When we look at all these things as part of a fundamental panel to see what's going on, and it's amazing if you start to fix these things, people get better. Sometimes you have to go deeper, right? It's not just always just cleaning up your diet
Starting point is 00:42:23 and eliminating inflammatory foods and adding a number of nutrients that may be helpful for your brain or nutrient deficient. It may also be like, okay, well, I gotta deal with the heavy metals or I gotta deal with Lyme disease or I gotta deal with the BC or I gotta deal with mold.
Starting point is 00:42:36 And those are things that we don't really deal with well with traditional medicine. But if you're seeing a functional medicine doctor, they can see you in your practice in Connecticut, they can come to our center in in Connecticut, they can come to our center in the in Lennox, Massachusetts, the Ultra Wellness Center. And we deal with all these chronic complex issues. And we deal with the sort of the crises in mental
Starting point is 00:42:54 health. And I, I did a documentary series years ago called a broken brain. And it's really about, you know, how most of our brains are not working properly. And we don't really have a great way to deal with brain disorders because our whole thinking has been completely wrong. Focus and, I mean, I have so many, I feel like over half my patients, you asked about brain fog or focus.
Starting point is 00:43:14 It's like more than half of them have an issue. It's this like of the activity with their brain and managing everything that they're doing and rates of what ADHD going up and anxiety, is it truly that or is it, you know, we're just doing too much as a society. Part of what I talked about in the presentation giving for IFM too, were the other things outside
Starting point is 00:43:36 of like even diet is like the benefits of like sauna and how that showed to decrease the RP levels and also in studies that they did in Europe for men that there was like decreased chance of like things like schizophrenia, forced bathing. Forced bathing actually. That's crazy, wait, we just wanna stop there. You just said take a second of Sonic
Starting point is 00:43:53 and help reduce psychiatric symptoms and even schizophrenia. Exactly, schizophrenia. That's crazy. Yeah, and this was a study of men at large for like decades. And they showed that there were lower rates of things like schizophrenia. If you look at also it decreases CRP levels, which we keep talking about with inflammation, you also look at like forest bathing.
Starting point is 00:44:13 There was a study in Japan to show that the CRP levels went down significantly with more forest bathing and lasted for a period of time. So these are all the things that you can get people to do in small steps that just shows there's that lack of connection. Like loneliness, I think, is a huge factor, and that's one of the biggest things we're always trying to work at in our office.
Starting point is 00:44:34 Even with anxiety, they've shown the most effective is doing that with group therapy, like treatment plus therapy. I think it takes a community, but it's like you doing things to detach yourself from technology, like, you know, grounding, sauna, those things, but then also your community of people
Starting point is 00:44:52 around you to be able to support you as well. When you look at ADD and ADHD, it's basically described as a set of symptoms. The way we diagnose in medicine is based on basically, I think a very outdated model, which is describe the symptoms and if somebody fits those symptoms, they have the disease. We say, oh, you have trouble focusing
Starting point is 00:45:16 or paying attention, you're inattentive, you're hyperactive. I know what's wrong with you, you have ADHD. No, that's just the name of the disease. It's not the cause of the disease. And so we describe every disease, including particularly mental diseases, mental disorders, through this lens of describing symptoms, not causes. Punctual medicine is about causes. So what are the causes? Well, I'm going to take through a case because I think it'll be a very interesting way to think about this story. And this is a case that really blew my mind.
Starting point is 00:45:49 So the mother brought in her kid to see me, who was 12 years old, and then two months later brought him back. And the transformation was remarkable, but she brought his homework, and we're gonna put it in the show notes so you can actually see graphically changes in brain function in just two months
Starting point is 00:46:04 with a kid who had severe brain disorder. He had a broken brain and he could not write legibly to save his life. It was like chicken scratch or a three-year-old writing versus a 12-year-old. And then within two months, his handwriting totally normalized. And the question is, what happened? So I'm going to take you through what happened. I'm going to explain you a story.
Starting point is 00:46:26 And I'm going to actually help you understand how we need to start approaching these disorders in a very different way. So basically, one day, this woman walks into my office, a professional woman, businesswoman with her 12-year-old son, who had multiple psychological and physical diagnoses, who were seen by many doctors, seven
Starting point is 00:46:46 different doctors, right? He had, you know, a psychiatrist, he had a GI doctor, he had an allergist, he had a pulmonologist. I mean, the list goes on. So nobody was talking to each other and all was treating, they were all treating different things. So he was diagnosed with ADD, and no one seemed to sort of say how does this one kid have all these problems, right? Is it just bad luck or are they connected? And so functional medicine is about looking for the patterns in the connections that give rise to the clues about the cause. So basically he was diagnosed with ADD when he was a little kid. He couldn't
Starting point is 00:47:22 focus in school. He was zoned out. He was disruptive. I mean, he was kicked out of kindergarten. I mean, who's kicked out of kindergarten, right? He had terrible writing. We call it dysgraphia. He was pretty good in math, but basically was a disaster. Behaviorally, academically, socially,
Starting point is 00:47:42 was just not thriving. And physically, he had all these issues, right? He had asthma. He had environmental allergies. He had sinus problems. He had post-nasal drip. He had sore throats. He got skin issues, eczema, nausea, stomach aches, diarrhea,
Starting point is 00:47:55 headaches, anal itching, which we'll get to why that is. He had canker sores, which are immune things, right? All this immune inflammation, muscle aches, muscle cramps. He was hypersensitive to loud noises, to smells. to why that is, he had canker sores, which are immune things, right? All this immune inflammation, muscle aches, muscle cramps. He was hypersensitive to loud noises, to smells. He was sneezing a lot. He had hives, itchy skin, bumps, frequent infections. He couldn't sleep well.
Starting point is 00:48:14 He had trouble breathing when he slept. He had like anxiety. He was fearful all the time and he had tons of sugar cravings. Now that is a long list of problems. My joke is I take care of patients and I'm a holistic doctor because I take care of people with a long list of problems. My joke is I take care of patients and I'm a holistic doctor because I take care of people with a whole list of problems.
Starting point is 00:48:28 And he had a whole list of problems and nobody says, how are all these connected? They're all inflammation. What we now know is that ADD, autism, depression, dementia, Parkinson's disease, these are inflammatory diseases of the brain. Even schizophrenia, bipolar disease, all these are inflammatory brain disorders.
Starting point is 00:48:48 So doctors were treating, and all these specialists were treating all the symptoms with seven different medications from five different doctors, Ritalin for ADD, allergy medicine, inhalers for his asthma, acid blocking medicine for his stomach, painkillers for his headaches. I mean, it's quite a drug cocktail for a 12 year old-old kid, and he didn't really get that much relief anyway
Starting point is 00:49:07 on any of his symptoms. And no one said, you know, how is this connected, right? How is this connected? And why is this kid suffering from all this? And so really, this is just how medicine is. We see specialists after specialists, we get pill after pill, we get a pill for every ill, and it was just kind of a mess.
Starting point is 00:49:24 So most psychiatrists are trained about the brain. Uh, or really the mind right? They don't really learn much about the brain They don't they think you know, it's basically, you know, their job is from the neck up and it's all emotional psychological But we often misappropriate Psychological or psychiatric diagnoses to physical things, right? If you have mercury poisoning, it can cause depression, right? If you have huge amounts of inflammation from an altered microbiome, you can have ADD. So you need to figure out what the root causes
Starting point is 00:49:59 and not just be slapping on different drugs for different diseases. So, you know, it's important to understand what the physical things are, but not to get stopped there, and not to just say, let's treat each one separately. We have to see how they're connected. So the medications he was on were kind of nuts,
Starting point is 00:50:15 and they weren't helping much. But he's not alone. Most kids own tons of medications, from allergy medication to antidepressants to stimulants. And we're seeing kids with mental behavioral emotional problems like Clayton had and they're now getting drugs like anti-psychotic medications they give to schizophrenics like risperidol or anti-seizure medications, trileptil or antidepressants like I said like Prozac or all the stimulants like Ritalin,
Starting point is 00:50:41 Concerta, Adderall or Vyvanse Now, when we dug below the surface with Clayton, we found all sorts of stuff. Now, in functional medicine, I don't actually treat disease. I don't really care that much about the name of your disease. What I care about, what is going on in the systems in your body that is out of balance, and how do I figure that out? And one of the basic categories of things that matter, right, it's our lifestyle and all the nutritional exercise,
Starting point is 00:51:06 sleep, relationships, it's various factors that cause us to get out of balance, toxins, allergens, microbes, poor diet, stress, all these things wash over these systems and create imbalance. So my job is a detective to figure out where this particular child's imbalances were and fix them and see what happens, right?
Starting point is 00:51:24 I just kind of put things back in balance like turning up a car and then you kind of hope, crush fingers and usually it works. Sometimes you kind of get stuck or there's something else you missed, but it's actually quite effective. So first step was nutrition. I mean, Clayton had, which was his name,
Starting point is 00:51:40 had the worst diet. All he ate was junk food, processed food. I don't think he ever saw a vegetable in his life. And it's typical of a lot of these kids who are on the spectrum of autism or ADD. They typically have very finicky dietary habits. They typically eat tons of carbs. They love gluten and dairy.
Starting point is 00:51:56 But he wasn't just eating whole wheat bread and sheep cheese. He was eating junk food, trans fats, food coloring, additives, tons of sugar, and all these things have been associated with ADD. Now when we looked at his lab testing, we found some really interesting things. And I think most people do not dig below the surface
Starting point is 00:52:14 to look at labs. And we did a deep dive. We found he had omega-3 fat deficiency, APPA and DHA, which are incredibly important for brain function. 60% of your brain is DHA. And if you have low levels, it's associated with ADD, as well as eczema, immune deficiency, a lot of the things that he had. We looked at his vitamin levels. We saw low levels of amino acids like tryptophan. We saw metabolic pathways that were indicating he had a deficiency
Starting point is 00:52:42 of B6, which is important for making serotonin from tryptophan and helping his mood, right? His mood was unstable, he had sleep issues. And so that, you know, B6 was a big factor and it's often with kids with ADD or autism. And we see, you know, also vitamin A deficiency, which is important for immunity. And the omega-3 deficiency and vitamin A deficiency
Starting point is 00:53:05 led to little things like bumps on his back. So we call these hyperkeratosis pilaris. So I could touch his skin, I could see little bumpy things. That was because of these nutritional deficiencies. He was low in vitamin D, he was low in vitamin E and beta-carotene because he ate vegetables, right? So it's a diet very high in junk food,
Starting point is 00:53:24 which is nutrient poor and very low in nutrient dense food. He had low levels of zinc and zinc we know is important for immune function, regulates hundreds of enzymes, it's important for getting rid of heavy metals, it's important for ADD and autism. And it was really consistent with his symptoms of frequent infections of eczema, allergies, hyperactivity. Those had low magnesium,
Starting point is 00:53:44 magnesium deficiency is really common. And it led to headaches, allergies, hyperactivity. Those are low magnesium. Magnesium deficiency is really common and it led to headaches, anxiety, insomnia, muscle cramps, spasms, aches, hypersensitivity to loud noises. All these are signs of magnesium deficiency. And we do testing. And I recently started a co-founder company called Function Health to help people
Starting point is 00:54:03 get access to their own labs and to be able to look at some of these deep nutritional testing as well as metabolic testing and many things we're gonna talk about with Clayton. Things that are often missed by a traditional doctor are not checked. When was the last time your doctor checked your omega-3 level or vitamin A or magnesium or vitamin D?
Starting point is 00:54:17 These are all part of our standard Function Health panels and I think it's really important for you to think about. So go check out functionhealth.com. You can sign up for the wait list. it gives you a really great guidance on how to optimize your health using personalized recommendations. So the next thing we looked at besides nutrition was his immune system because he has so many inflammatory things right. He had you know infections he had asthma he had sore throats he had allergies he had all these inflammatory things. So it was like flashing red light, inflammation, inflammation, inflammation is at the root of so many problems, including brain diseases.
Starting point is 00:54:51 So we looked at the factors that cause actually inflammation, such as food allergies, environmental allergies, molds, toxins, chronic low-grade infections, maybe had a whole bunch of these things. We found some testing. We looked at food sensory testing, and he had a lot of foods he was reacting to, about 18 different foods, including dairy, peanuts, yeast, citrus, foods, gluten, especially gluten. And he had gluten antibodies, which, again,
Starting point is 00:55:15 are not checked by most doctors, but actually were elevated. And so we found he really was sensitive to gluten. So gluten basically is a huge factor for these kids, often with ADD or erythrocytes. doctors but actually were elevated and and so we found he really was sensitive to gluten. So gluten basically is a huge factor for these kids often with ADD or or autism. It triggers this low-grade chronic inflammation in the brain and immune response. It makes leaky gut worse, causes canker sores. So when you have canker sores I was clued in that he might have a gluten issue. It can be celiac disease or gluten sensitivity.
Starting point is 00:55:45 And he had elevated anti-glyde antibodies, which was basically an autoimmune reaction to the proteins found in gluten and that are found in wheat, rye, barley, spelt, and oats. So massive inflammation, and we knew we had gluten issues. We knew we had food sensitivities and some other things that were causing it. And he also had tons of gut symptoms, right? So we looked at his digestive system, nausea,
Starting point is 00:56:08 diarrhea, stomach aches, anal itching. He had a sensitive stomach. He had lots of antibiotics for sore throats and he had then yeast overgrowth because of all the antibiotics and abnormal gut flora. We looked at his stool test. He had a leaky gut, which basically creates the damage in the gut that allows food proteins and bacteria to leak in. And his immune system was just so pissed off. And it wasn't just affecting his asthma and allergies. It was also affecting his brain.
Starting point is 00:56:35 The next thing we looked at were toxins. Because we take a look at nutrition. We take a look at gut. We took at immune issues. We look at the causes. And so we started to look at whether or not he had any environmental toxins, which we know can cause ADD and even autism.
Starting point is 00:56:49 And heavy metals were an issue for him. He had high levels of lead and mercury. And he had similar probably exposure to other kids, but they're often not looked at and not treated. They might check up blood lead level. They don't ever look at a challenge test. And genetically, nutritionally, he couldn't really detoxify these.
Starting point is 00:57:04 And we know mercury and lead are associated with GI symptoms, autoimmune issues, cognitive problems, that lead has been actually very well linked to ADD and behavioral issues, cognitive problems, and there's no doubt about the date on this. You don't have to believe me, just go to PubMed and put lead and ADHD and you'll come up with plenty of scientific papers to explain how this actually is all working. So basically, maybe, you know, the world is polluted, right? We have so many cement factories, coal burning factories, all of which spew out lead and mercury. It goes into the soil. Kids are playing in the dirt or maybe there's toys made from China that are coated with lead paint or maybe the people have leaded paint in their house
Starting point is 00:57:46 or even lead covered glasses or I mean, uh, crystal glasses or more fancy plates. Um, but basically he was exposed to all these dangers of the industrial revolution. And he also had a little bit of mold in his house and he had food additives that, you know, we can't measure those things, but I'm sure they were causing a problem. So basically his problem wasn't riddle and deficiency or bad parenting, right? The cause was in his diet.
Starting point is 00:58:14 It was environmental toxins. It was in his microbiome. And so we basically constructed a very simple treatment. So we think, oh my God, there's so many things, he's got 25 different diseases, right? Well, what do you do? So it was quite simple. We basically looked at the causes.
Starting point is 00:58:33 So we basically looked at the nutritional efficiencies, the toxic, the environmental toxins he was exposed to the food sensitivities, all the processed food we got rid of the gluten, all the yeast overgrowth. And we found out what sort of was causing him to be out of balance, right? So basically the body is a system of equilibrium, and either you have too much of something
Starting point is 00:58:54 that's causing you to be out of balance or not enough of something that's causing you, that you need to be in balance, right? You have all these deficiencies of nutritional stuff, but all these other things like yeast overgrowth, and heavy metals metals and gluten, they were irritating the system. So we can't just do one thing.
Starting point is 00:59:08 And I think in medicine they go, well, let's do one thing and see what happens. Well, we won't know unless you do a randomized controlled trial with one intervention and one outcome. Well, that's just BS because if you want to grow a plant, you don't go, well, I'm just going to give it water, but no soil and sun and see what happens. Or I'm going to give it water, but no soil and sun and see what happens. Or I'm going to give it soil, but no, you know, water or, or, or, or, or, or,
Starting point is 00:59:29 well, I'll give it sun, but no soil and water. You know, it's just the whole thing is, is an insane backwards antiquated framework for thinking about disease. And it's why we are in this really powerful transformation in medicine right now. It hasn't quite caught up to the clinic in most cases, but it really is where we're all going. If you love this podcast, please share it with someone else you think would also enjoy it.
Starting point is 00:59:52 You can find me on all social media channels at Dr. Mark Hyman. Please reach out. I'd love to hear your comments and questions. Don't forget to rate, review, and subscribe to The Dr. Hyman Show wherever you get your podcasts. And don't forget to check out my YouTube channel at Dr. Mark Hyman for video versions of this podcast and more. Thank you so much again for tuning in. We'll see you next time on The Dr. Hyman Show. This podcast is separate from my clinical practice at the Ultra Wellness Center, my work at Cleveland Clinic and Function Health where I am
Starting point is 01:00:17 Chief Medical Officer. This podcast represents my opinions and my guests opinions. Neither myself nor the podcast endorses the views or statements of my guests. and my guests opinions. Neither myself nor the podcast endorses the views or statements of my guests. This podcast is for educational purposes only and is not a substitute for professional care by a doctor or other qualified medical professional. This podcast is provided with the understanding that it does not constitute medical or other professional advice or services. If you're looking for help in your journey, please seek out a qualified medical practitioner. And if you're looking for a functional medicine practitioner Visit my clinic the ultra wellness center at ultra wellness center comm and request to become a patient It's important to have someone in your corner who is a trained
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