The Dr. Hyman Show - Strategies To Reverse Autoimmune Disease

Episode Date: November 17, 2023

This episode is brought to you by Essentia and Cozy Earth. Simply put, autoimmune diseases are conditions where the body’s immune system attacks its own tissues rather than a foreign molecule like b...acteria, and they are a huge problem both in this country and worldwide. You’re probably familiar with the most common autoimmune diseases, like rheumatoid arthritis, lupus, multiple sclerosis, inflammatory bowel disease, type 1 diabetes, hypothyroidism, and psoriasis. But there are many more autoimmune diseases that affect the nervous system, joints and muscles, skin, endocrine gland, and heart. In today’s episode of my series I’m calling Health Bites, I talk about the main causes of autoimmune disease, the conventional medicine approach versus the Functional Medicine approach to treating autoimmune disease, and how to reverse the course of these devastating illnesses.  This episode is brought to you by Essentia and Cozy Earth. Receive an extra $100 off your mattress purchase on top of Essentia’s huge Black Friday sale! Go to myessentia.com/drmarkhyman and use code HYMAN at checkout to get this great deal. Right now, get 40% off your Cozy Earth sheets. Just head over to cozyearth.com and use code DRHYMAN. Here are more details from our interview (audio version / Apple Subscriber version): What is autoimmunity, and what causes it? (6:14 / 4:25) A patient case I treated of a girl with autoimmune disease (8:51 / 7:04) A Functional Medicine approach to treating autoimmune disease (13:00 / 11:14) Strategies to reverse autoimmune disease (26:22 / 24:35) Mentioned in this episode The Blood Sugar Solution 10-Day Detox Diet Diagnostic tests and biomarkers mentioned in this episode Celiac Gluten antibodies Anti-gliadin antibodies* Tissue transglutaminase antibodies* *IgA and IgG recommended for both

Transcript
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Starting point is 00:00:00 Coming up on this episode of The Doctor's Pharmacy. We need to look at each person and say, hey, do they have any allergy stuff? Is there gluten sensitivity? Infections that might be confusing their immune system? Do they have a toxin like heavy metals or pesticides? What's their diet like? Are they eating an inflammatory diet? How much stress do they have?
Starting point is 00:00:17 All these things need to be considered. We live in such an exciting time. We're actively entering a healthcare revolution where consumers want to learn about their body. There are tens of millions of wellness enthusiasts who want to learn about their hormones or gut health, advanced lipids, and more. But as a healthcare practitioner, how do you make sure that when a patient walks into your office and says, Hey, I really want a Dutch Complete or a GI map, that you have the right answers and the tools? Well, Rupa University is the number one educational institute where over 20,000 practitioners a year
Starting point is 00:00:48 learn about functional and specialty lab testing. Not only do they have absolutely free live classes hosted every week, but they bring in industry experts to teach in-depth six-week boot camps on all of the most popular functional tests. If you want to level up your knowledge of functional lab tests,
Starting point is 00:01:02 make sure to visit rupainiversity.com. It's r-u-p-a-university.com. You know I'm always experimenting with the latest health advances, and I found that tracking my blood glucose is one of the most insightful and accessible ways to understand my unique reactions to food. Poor glucose control is tied to all kinds of issues like weight gain, fatigue, type 2 diabetes, Alzheimer's, heart disease, and stroke. But it can be hard to know exactly how your body's reacting to the glucose in different kinds of foods because we're all different. That's where Levels comes in. It's a state-of-the-art app right on your phone that pairs with a continuous glucose monitor to show you how food and lifestyle factors affect your health in real time. With Levels, I realized I could make helpful tweaks in some of
Starting point is 00:01:41 my favorite recipes. For example, adding extra avocado and a few less blueberries to my morning smoothie kept my blood glucose smooth and even, while too much fruit and too little fat sends me into a spike. Right now, Levels has a special offer for my audience if you head to levels.link forward slash hymen. That's L-E-V-E-L-S dot L-I-N-K forward slash hymen. And now, let's get back to this week's episode of The Doctor's Pharmacy. Welcome to The Doctor's Pharmacy. I'm Dr. Mark Hyman. That's pharmacy. That's the place for conversations that matter. And if you or anyone you know has had an autoimmune disease, I think this conversation is going to matter a lot because we're going to get deep into why there's so much autoimmune disease, what the real causes are, and how to deal with it aside from taking medication that's extraordinarily expensive
Starting point is 00:02:30 and has significant side effects. Today, we're doing this part of our Health Byte series, which are little small bites of information that you can use to take small steps every day to get yourself healthier and live a long, healthy life. Okay, let's get into it. What about autoimmune disease? There are over 80 million Americans, some estimate 100 million Americans, who have an autoimmune disease. If you collectively take all the autoimmune diseases together, combined, it's more people that have cancer, heart disease, or diabetes combined. Wow. Okay. So how come we don't hear about it? Why? Because every specialty has their autoimmune disease. You've got the neurologist, you've got MS, you've got the GI doctors, you've got colitis, you've got the rheumatologist, you have rheumatoid
Starting point is 00:03:15 arthritis, you have the dermatologist, you have psoriasis, and I could go on and on. You've got the thyroid doctors, you've got Graves' disease or Hashimoto's. So essentially, everybody's silent. The problem is that autoimmune disease is not a bunch of really different diseases. It affects different people differently, but there are common principles that we can use to address the causes and get people healthy. So this is really an epidemic, and it's getting worse and worse. And by the way, this is not something you see in countries that are really living in ways that are traditional. For example, I just got back from Mongolia on a horseback trip.
Starting point is 00:03:52 There was nothing there. I mean, they were living and eating in the way that they had done for thousands of years. There was no cell service. There was no Wi-Fi. They were living in earth. They were having yak milk. And they're living close to the earth. They're living on the ground. They're living in earth, they were having yak milk and they're living close to the earth, they're living on the ground, they're living in dirt basically and these people don't get
Starting point is 00:04:09 autoimmune disease. If you look at traditional hunter-gatherer tribes, they don't get autoimmune disease. They don't get allergies, they don't get asthma, they don't get autoimmune disease and yet in our western society, we get a lot of these problems, allergies, asthma, autoimmune diseases, skin disorders. I mean we just see it left and right. So the question is why? Well, it's because something has dramatically changed in our modern world. And we're going to get into what those things are, but we're just seeing so many people
Starting point is 00:04:36 with autoimmune diseases and the rate of these diseases is going up as infectious disease went down. And there's some connections there we're going to talk about. So we're going to talk about the main causes of autoimmune disease. And yes, we know a lot of what the causes are, even though most traditional doctors don't treat the cause. They simply use medication to suppress inflammation and suppress the symptoms, which can make people feel better in the short run, but don't actually deal with the problem. It's like taking morphine and having a broken ankle and being able to walk on it. It still kind of works, but, you know, not the best idea.
Starting point is 00:05:07 And, yes, sometimes it can prevent more complications, more serious consequences of autoimmune disease, such as joint destruction or kidney failure or other things. So it's not that medications are all bad. It's just that if there's a better way, let's talk about it. So we're going to talk about the conventional versus a functional medicine approach. I'm going to tell you a story about a patient who I had. It's just that if there's a better way, let's talk about it. So we're going to talk about the conventional versus a functional medicine approach. I'm going to tell you a story about a patient who I had. It's just remarkable. And if I'm not making this up, which I'm not, and if this is true, which it is, then what are the implications of this story of this young girl who suffered from
Starting point is 00:05:41 one of the worst autoimmune conditions I'd ever seen and her recovery. If even one case could get better using a different approach than we currently use, shouldn't we be spending billions of dollars studying it? No, we're not doing that because it's not a drug. And yes, the biggest profit center for many of the pharmaceutical companies are these autoimmune drugs. It costs about 50 grand per person per year, sometimes more for these medications. So let's kind of take a step back and let's talk about what is autoimmunity, what causes it, and why should we be so concerned? Well, autoimmune disease, like I mentioned, things like rheumatoid arthritis, thoracic arthritis, lupus, type 1 diabetes, Graves' disease, Hashimoto's disease, Malteserosis, Crohn's disease, colitis, I mean, the list goes on, are all diseases where the body is attacking itself.
Starting point is 00:06:37 The immune system is out of control. It creates systemic inflammation. And depending on your genetic and the various issues you have, it attacks different parts of the body. But essentially, the process is the same where we create autoantibodies. We create antibodies, which are normally designed to fight infection or even to kill cancer. We create antibodies to then attack our own tissues. And that's when we get into trouble. So basically, we have this runaway inflammation. We have an immune system that's confused. And our immune system is supposed to empty up when we have foreign invaders,
Starting point is 00:07:13 like an infection, or when we have cancer to kill the cancer. And that's good. Or when we're maybe trying to deal with our gut and creating antibodies and different food things that are in there, although that usually is because of a leaky gut. And so basically, your immune system is your first line of defense. But when it goes awry, it causes widespread destruction in the body. And your own cells and tissues and organs get caught in the crossfire. And it's not a good thing. It's just not a good thing. It's good when it comes to cancer, when it comes to
Starting point is 00:07:45 infections, we want that. What we see now is a total epidemic about immune disease that is being completely misunderstood. In fact, now there's even a conversation about pre-autoimmune disease, that a lot of people are seeing positive levels of ANA antibodies, which we test for at functionhealth.com, which is a testing platform where you can order your own test, essentially, and get the results and have an interpretation and figure out what's going on. So we're picking up a lot of people, probably 30% of the people that we see, just young, very healthy people, not really sick people generally, are showing up with an elevated
Starting point is 00:08:23 level of an antibody called antiionucleic antibody, which is an early sign of autoimmune disease. So this is really scary to me as a doctor. So the question is, you know, why is the body doing this? What is the root cause? You know, most doctors, when they think of a patient, they essentially go, well, here's the symptoms, here's the lab test. Okay, you have these tests, you have these symptoms that are off. It means you have this or that disease. We name the disease and then we blame the disease for the problem. Now, this young girl, Isabel, I was talking about before, she came to see me when she was 10 years old and she had a severe autoimmune disease called
Starting point is 00:08:57 dermatomyositis. Dermatomyositis is nobody's best friend. Essentially, it's one of the worst autoimmune diseases you can have with everything, your joints, your skin, your liver, your blood vessels, your muscles. I mean, pretty much everything gets affected. And so you have widespread destruction throughout your body. Now, the doctors didn't say, gee, why is her immune system so pissed off? Instead, they gave her a pile of drugs, steroids, cancer drugs to suppress her immune system so pissed off? Instead, they gave her a pile of drugs, steroids, cancer drugs to suppress her immune system. They're about to put her on an immune blocker called TNF-alpha, which is an antagonist, which is basically blocking the inflammation marker in the
Starting point is 00:09:38 blood that's responsible for a lot of autoimmune disease, which can be helpful. But again, nobody was asking a very simple question is, why is she so inflamed in the first place? Why is her immune system so pissed off? Now, as I mentioned, Isabel had one of the most severe cases of autoimmune disease I'd ever seen at 10 years old. She had severe skin rashes. That's the dermatitis. It's pretty much itis means inflammation.
Starting point is 00:10:00 She had every kind of itis. She had vasculitis, which is inflammation of your blood vessels causing rain nodes. She had gastritis causing inflammation of her esophageal tract and causing terrible reflux. She had hepatitis affecting her liver. She had inflammation of her blood cells. I don't know what you call that, but she had low white count and low red cells. She had severe muscle damage. So she had myositis and very severely elevated muscle enzymes. She had also severe arthritis and joint swelling. So basically everything was under attack. Now this cute little girl, Isabelle, was 10 years old. She was from Texas. She loved riding horses.
Starting point is 00:10:40 She couldn't do the most basic things anymore. She couldn't squeeze her hand or make a fist. Her tips of her fingers and her toes were totally numb all the time from Raynaud's disease, which is the damage of the blood vessels, autoimmune condition. She had rashes all over her body that were irritated. She was exhausted. She felt miserable. Her hair was falling out. And she was being treated by doctors who were doing the best they could but were using the old paradigm.
Starting point is 00:11:07 They were saying, okay, well, she's got inflammation, let's get that under control. So they give her a huge dose of steroids, something called Stolomedrol which is essentially a horse dose of 1200 milligrams intravenously. She has to go to the hospital and get intravenous steroids every three weeks just to sort of be able to function. She was on methotrexate, which is a chemo drug, because that suppresses inflammation. She was on also aspirin to thin her blood because the inflammation caused her
Starting point is 00:11:35 blood to clot. She was on acid blockers because of the reflux from her stomach. She was on calcium channel blockers to help open up her blood vessels because of her Raynaud's. I mean, let alone, she was on more drugs than even 80-year-olds beyond. And despite these megadose medications, she wasn't better. I mean, she was managed. They call it managing her disease.
Starting point is 00:11:55 Her labs were all abnormal. Her skin was still inflamed. Her joints were still inflamed. She just wasn't in the hospital, basically. And her doctors wanted to add another drug called the TNF alpha blocker, things like Remicade or Humira you might have heard about. You probably saw the ads on TV because there's tons of ads for these drugs on TV, which is a whole other topic that farmers should not be advertising on TV.
Starting point is 00:12:17 But anyway, basically this drug can be helpful, but if you don't have anything else to do to fix the problem, but it increases the risk of cancer and also infections because it suppresses the immune system, right? So it turns off the inflammation. And we need inflammation for cancer and infection, but not for autoimmune disease or allergy, right? So that's a problem.
Starting point is 00:12:36 Now, her mom was not happy with this plan, so she brought her to see me, and we did a pretty simple program. It wasn't that hard, but I asked a very different set of questions. I asked not, you know, what's the inflammation, but what's the cause? Not what's the name of her disease, but what's the cause of her problem? What's pissing off her immune system? And so that's the job of a functional medicine doctor, to be a detective, to look deeply into the root causes and to try to understand why.
Starting point is 00:13:06 And I always say functional medicine is the medicine of why, conventional medicine is the medicine of what. What disease do you have and what drug do I give, not why. In fact, I always say just because you know the name of your disease, it doesn't mean you know what's wrong with you. Say it again, just because you know the name of your disease, let's say dermatomyositis, it doesn't mean you know what's wrong or what's causing it, right? Dermatomyositis just means skin and muscle inflammation because those are the two most prominent symptoms. It doesn't mean anything.
Starting point is 00:13:39 It's just a fancy medical word describing the symptoms, nothing to do with the cause. So functional medicine gives us a map to help understand why, to understand inflammation. I often call myself an inflammologist and that's what we should be, inflammologists. In fact, inflammation in autoimmune diseases is a real issue and obviously in allergy and asthma, but also in heart disease and cancer and diabetes and obesity and dementia. Pretty much all the age-related diseases are all diseases of inflammation. In my book, Young Forever, I did talk a lot about how one of the hallmarks of aging is inflammation
Starting point is 00:14:15 or what we call inflammation. So when we look at the causes, how do we start to think about causes systematically? How do we have an organized approach to diagnosis about what is causing the body to react to something? Now, what we really know is that the body is not really attacking itself on purpose. It's trying to do the job that it's supposed to do, which is fight bad things, right? Bad things. What are the bad things? Allergens, bugs, microbes, and mostly imbalances in your gut or your microbiome. We'll talk about that. Toxins. And, you know, also stress and poor
Starting point is 00:14:54 diet also drive inflammation and psychological stress, physical stresses. But basically, there's really five causes of almost all disease. Allergens, and that can be a food sensitivity. It can be a true allergen, like a phenology. It can be microbes. It can be something like Lyme disease or hepatitis or anything like that. Plus, it can be just dysbiosis, imbalances in the floor and the gut. It can be toxins, petrochemical toxins, environmental toxins from pesticides, herbicides, plastics, as well as heavy metal toxins, flame retardants. I mean, let's go on and on.
Starting point is 00:15:30 So, in fact, there's a whole school of research now on what we call autogens. Autogens are environmental toxins that trigger an autoimmune response. So all these factors need to be investigated. We need to look at each person and say, hey, do they have any allergy stuff? Is there gluten sensitivity? Are they harboring latent infections that might be confusing their immune system? Do they have a toxin like heavy metals or pesticides? What's their diet like?
Starting point is 00:15:59 Are they eating an inflammatory diet? How much stress do they have? All these things need to be considered and need to be investigated. And that's really what functional medicine does. It helps you investigate the root cause. It's really a diagnostic model to think about an operating system, to think about the body as a system, to think about root causes and to help the body restore balance. That's the goal. So basically, you got to figure out the cause. If you want to fix autoimmune disease, you got to get to the cause. And, you know, unfortunately, medicine, we don't do a good job at that.
Starting point is 00:16:30 We get a little bit of that, but not much, right? If you have pneumonia, it's caused by streptococcal infection. Okay, you get penicillin, that's fine. But most diseases, chronic diseases, which by the way, 6 out of 10 Americans have, which are accountable for over 85% of 10 Americans have, which are accountable for over 85% of our healthcare costs, which are now $4.3 trillion. Caused by an infection like septicoccal pneumonia or hepatitis C. I mean, those are real.
Starting point is 00:16:57 They need to be treated. But that's not really the majority of problems people are seeing. So functional medicine docs really understand the body of the system. It's an ecosystem. And we seek the cause. We understand the basic interactions between them. We know when things go wrong, how to fix it, and understanding the interconnections between symptoms and organs and systems rather than all these specialties. You know, I always say, you know, I don't really need to know anything about, you know, the fine points of a particular autoimmune disease. I'll be a specialist in that area.
Starting point is 00:17:28 But I need to understand inflammation. I need to understand the root causes. And I can treat. I'd never seen a case of dermatomyositis in my life other than with traditional medicine care when I was in residency and early practice. But as a functional medicine doctor, I'd never treated
Starting point is 00:17:44 one before. But I knew exactly what to do because I followed the methodology of functional medicine. It provides a fundamentally different way of solving medical problems, gets to the root of the illness, and understands the disturbances that really are going on. So let's talk about Isabel a little bit more. So she, you know, I've seen good doctors and their response was to shut down this kid's
Starting point is 00:18:04 immune system. You know, let's, I've seen good doctors and their response was to shut down this kid's immune system. You know, let's let's let this kid suffering. Let's just throw the whole kitchen sink, the whole barn, everything. And that would have been OK. She might have done improvements in her symptoms, but she would have had a high risk for cancer, infection, osteoporosis, muscle weighting, psychiatric illnesses. And by the way, would have cost a huge amount of money forever, right? This is a 10-year-old girl. She's going to be on a drug that costs 50 grand a year for the next 60 years.
Starting point is 00:18:30 You do the math. That's one person. So we're talking about an untenable thing. So I asked really a simple question with this, which is why? I didn't focus on what the name of the disease was. I wanted to know why she's inflamed. When the inflammation started, how we can really find the root causes and how we get to restore balance in
Starting point is 00:18:46 her immune system. So it's not just not finding the cause, it's also understanding how to get the immune system working better, taking out the bad stuff, putting in the good stuff. So some insults usually are triggering some confusion. We call it molecular mimicry. There's a theory about what we just call molecular mimicry that the, for example, some food you're eating or gluten, you know, somehow confuses your immune system and it thinks your thyroid is, you know, some foreign object, but it's just cross-reacting with the gluten antibodies and that's why you end up with autoimmune disease. So, we were looking for toxins, we were looking for allergens, we were looking for bugs, we were looking for dysbiosis. And by the way, a lot of autoimmune disease starts in the gut.
Starting point is 00:19:26 And a lot of it starts with what we call leaky gut, which clearly she had. So when I kind of did her history, I very detailed history is really important. She had to find out what the story is, you know, not just, oh, here's your disease, but like what is your background, right? She had exposure to severe toxic mold, and that can be a trigger. That's a toxin. Stachybotrys is black mold, and that was in her house. And her mother also worked in limestone pits when she was pregnant,
Starting point is 00:19:52 and she exposed a lot of toxins and fluoride, even heavy metals. And she also had her immunizations before 1999. And before 1999, the American Academy of Pediatrics and the CDC had not removed amyloid primarisol from the vaccines for childhood vaccines. So they were getting a lot of, like, 167 times the amount of mercury in the vaccines
Starting point is 00:20:15 until they go, oh, wait a minute, we haven't had it all up, and it's a lot of mercury, so we better get it out. So they did remove it, except for flu shots. And so, if you're getting a multi-dose file flu shot which is what most people get a single dose doesn't have primarisol but it's a preservative so when you're sick and you're going over and over you got a multi-dose file you use it but it it's in the flu shot so she was getting flu shots every year and she also loved to eat sushi so she had large amount of tuna
Starting point is 00:20:41 sushi which she ate regularly got even more mercury she also had a large amount of tuna, sushi, which she ate regularly, got even more mercury. She also had a diet that was very high in sugar, lots of dairy. She also had many infections over her life, ear infections, sore throats, because she was on a lot of immunosuppressive drugs too. And steroids also caused problems. She had lots of antibiotics. So lots of antibiotics, lots of steroids, which causes real damage to the gut. So mold, mercury, antibiotics, sugar, dairy, gluten, junk food, all were potential irritants. So when I dug in, I looked at her lab tests pretty carefully. And, you know, in the conventional labs, they were a mess, right?
Starting point is 00:21:19 So they were, you know, high levels of muscle enzymes called CBK. Her liver function tests were off the chart. She had many autoimmune antibodies that were not just slightly high, they were off the chart high, like highest I've ever seen, anti-nuclear antibodies, rheumatoid factor, anti-SSA or show-in antibodies, anti-double-stranded DNA, anti-RNP, lupus anticoagulant, a lot of big mumbo-jumbo medical terms. But but basically the whole soup of autoimmune antibodies were just off the chart with her. And by the way, most autoimmune specialists do not check antibodies after the initial check because they go, oh, they don't ever go back to normal. Well, no,
Starting point is 00:21:55 they don't if you don't get rid of the cause, but they do if you get rid of the cause. And we saw that with Isabel. So she had also a lot of problems. She had lots of elevations and other markers of inflammation like C-rectal protein. Her white count was really low. Her red cells were low. Her vitamin D was really low. She had really high antibodies to gluten, which, by the way, is a common cause of autoimmune disease, probably the most common, and can trigger significant inflammation and leaky gut.
Starting point is 00:22:20 Her mercury level, we did a challenge test. It was off the chart. And the only way to really check is to actually give people a drug that pulls out the metals like DMSA. And she had a level 33. Normal is less than three. So it was very high. And at the first visit, I simply didn't do too much. I just put her on an anti-inflammatory elimination diet. So no gluten, no dairy, no sugar, no processed foods. Got rid of the most common allergens. I gave her multivitamin.
Starting point is 00:22:47 I got her vitamin D. I gave her some B12 and folate because of the acid blockers blocking that. I gave her fish oil, which is anti-inflammatory, evening primrose oil, which is anti-inflammatory. So I kind of gave her some basic nutritional support. And I also gave her an antifungal, Nystat. It's not absorbed, but it's used to treat uh yeast overgrowth and i suspected she had that due to the multiple course of antibiotics through the steroids she'd been taking also give her a liver support something called endoskeletal cysteine support liver and boost glutathione and i told her parents she probably
Starting point is 00:23:17 over time she's fine she's paper off her acid blocker the calcium channel blocker of her rain nose and the steroids if she could two Two months later, she comes back. And, you know, I didn't know what to expect. Two months later, she came back, and she said her symptoms were completely gone. Her rash was gone. Her joint pain was gone. Her hair was growing back. Her muscles weren't hurting.
Starting point is 00:23:35 It was an offer of medication. Her autoimmune markers were much, much better. Her muscle enzymes, her liver function, her C-reactive protein, all normal. Now, this was just two months. Then I added probiotics to help her digestive system heal a little bit and reduce the gut inflammation. I got her an accumulating drug called DMFA, combined the metals from her tissues and helped her treat it and helped get off the prednisone.
Starting point is 00:23:58 I gave her some herbs to help her adrenal glands because she was on a lot of steroids. And she tapered those down. Seven months later, everything was normal. All of her lab tests were normal, including her white count, her liver function, her muscle enzymes, the autoimmune antibodies, except for one called RMP, but every other autoimmune antibody that we mentioned that were off the chart, ANA, remicryl factor, all that stuff, completely normal. Never see that, right?
Starting point is 00:24:28 Her mercury came down from 33 to 16. After 11 months, her mercury came down to 11. Her gut inflammation was gone. Oh, yeah, she had a lot of gut inflammation. Even though she didn't have digestive symptoms, she had a test that we looked at stool testing. Why would I look at stool testing for an autoimmune patient? But basically, every autoimmune patient should have a stool test, right?
Starting point is 00:24:45 We use GIFX by Genova. Essentially, look at calprotectin, which is a marker you can actually get at a regular lab like Quest or LabCorp. And calprotectin is a marker of gut inflammation that is super important because it's used for colitis or Crohn's disease. But if you have just slight elevations, it all indicates a low level of inflammation. So really, really important. Now, after a year, she was off all her medications. Her labs were normal. She felt great. She was able to ride her horse again to
Starting point is 00:25:14 show. And she was just so excited. And I checked in with her like many years later, and she was great. And she was still fine. And we fixed the problem. So you get rid of the cause. It's not like stuff keeps coming back. Now, I've treated autoimmune disease for decades this way. And I've seen patient after patient. We've got resolved. Not everybody 100%, but the majority get better if not cured. Now, her case really isn't rare. And I take a similar approach pretty much with all autoimmune diseases.
Starting point is 00:25:42 You have to be detective and be an infirmologist. And what's going on? Now, if what I'm saying is true, like I said before, this should be a major effort from the NIH and the US government and private donations to actually fund research to look at this in a different way. But everybody's in their silos. Everybody's got their specialty. Nobody's thinking of the body as a whole system. Even at Cleveland Clinic, when we did research looking at psoriatic arthritis, rheumatoid arthritis, comparing the top rheumatologists there to our clinic, the functional medicine doctors, our patients did better in terms of all the objective metrics and the scoring systems for rheumatoid arthritis and
Starting point is 00:26:18 psoriatic arthritis. So I think this is really possible. So what are the 10 steps to think about to reverse autoimmunities? Well, it's really, really easy. First, take out the bad stuff and you have to find it all. And so for Isabel, it was a lot. It was mold, it was mercury, it was yeast in her gut, it was gluten, it was heavy metals, it was all the stuff. And then you have to add back the good stuff. We add back the good stuff, all the ingredients for good health, right?
Starting point is 00:26:40 Whole foods, right? Whole foods, right? All those nutrients, the balance of hormones, light, air, water, movement, connection, meaning, love, purpose. All these things are really essential ingredients for health. So if you have an autoimmune disease, I really encourage you to find a functional medicine doctor and work with them. We see patients at the Ultra Wellness Center. Check your labs out. Try functionhealth.com. Get your panel done. You can see if you have pre-autoimmune disease or other markers. And I think, you know, you'll be able to really move forward.
Starting point is 00:27:11 So what do you need to do? First, get tested for hidden infections. Now, there are a lot of things that can go wrong. When I say infections, it can also be dysbiosis, which is imbalances in the gut flora that cause gut and cause damage. By the way, 70% of your immune system is in your gut. So if there's a damaged gut lining and you're getting food and bugs leaking in, your immune system is seeing that. It's like, ah, let's create an immune response.
Starting point is 00:27:36 And that's essentially what happens. But that's probably the most common cause. Gluten is a big factor in causing leaky gut. It's probably one of the biggest factors because it increases something called zonulin, which disturbs the tight junctions in the cells that hold them together, and allows food and bacterial proteins and things to leak in. But other things can be factors too. You can have a parasite. For example, parasites are associated with rheumatoid arthritis. It can be Lyme disease, which has been linked to autoimmune disease, other tick infections. You need to be a detective and be able to figure that out.
Starting point is 00:28:06 Check for heavy metals. Check for environmental chemicals. Really important, like mercury. Fix your leaky gut. Really important. And that's so important. I think we just talked about leaky gut, but get rid of the bad bugs, the yeast, parasites, bad bacteria.
Starting point is 00:28:24 Provide this program that you need to actually heal your gut. We call it a 5R program in functional medicine, which is removing the bad stuff like bad foods and inflammatory foods and allergens, bad bugs, and then replacing things that are missing like digestive enzymes or prebiotics, re-inoculate with healthy bacteria, probiotics, repair, which is provide the nutrients for gut lining healing, for example, glutamine and zinc and fish oil and even primrose oil many other compounds are really important vitamin A for healing gut and and then the fifth R is restore which is to reset your nervous system and that means dealing with stress differently
Starting point is 00:28:59 super important so make sure you check that also if you think you uh if you have an autoimmune disease or you think you might you 100% want to get checked for celiac and you want to look at gluten antibodies any glide antibodies as well as tissue transmittance antibodies iga and igg for both and we'll put this all in the show notes but it's super important as a screening test and even if you don't have full-blown celiac there's non-celiac gluten sensitivity, so you may have even with levels that don't approximate a level that would be considered celiac, actually you might still have a lot of reaction. So that can be important. Also, I encourage people to try an elimination diet as a first step. And I wrote something called the 10-Day Detox Diet, really important. And I wrote this because I saw so many patients in my practice who were struggling with various autoimmune diseases,
Starting point is 00:29:50 gut issues, metabolic issues, prediabetes, weight issues. And by far, this is the most powerful therapeutic tool that I have in my arsenal, which is basically an elimination diet, getting rid of processed foods, sugar, dairy, gluten, grains, beans, nuts, and seeds and things you can have, but the other things you can't. So it's basically lots of veggies, protein, no such veggies, and it's quite healing and powerful. So I encourage people to try that. It's super low cost, super easy to do.
Starting point is 00:30:19 You can, we're going to put a link in the show notes to my book, The 10 Day Detox Diet, which you can follow as a cookbook as well. Also, you can take things that help calm your immune system down, making sure you're on the right nutrients. Vitamin D is essential for autoimmune disease prevention. If you have MS, for example, we know if you have low levels of vitamin D, you're linked to MS and other conditions. Vitamin D, fish oil, vitamin C, probiotics, a lot of things are available. And you can find them all on our online store at store.drhyman.com. And inflammatory herbs can work great.
Starting point is 00:30:51 So curcumin, boswellia, ginger. You often use a product called Zyflamand, Z-Y-F-L-A-M-E-N-D, which is a combination of different herbs, also known as inflammasin. It can be very helpful. Regular exercise, very inflammatory. De. Regular exercise, very inflammatory. Dealing with stress, very inflammatory. So meditation, yoga, deep breathing, sleep is super anti-inflammatory. You get eight hours every night.
Starting point is 00:31:14 Super important. So these are just sort of high-level thinking, but this is not hard for most people. Most of the time, you don't need a doctor, although sometimes you need to do some investigations like a stool test, having a mental test, and so forth, food sensitivity testing. But I encourage you to really not accept the traditional view of autoimmune disease and to actually start to take ownership by digging into the root causes. So no matter what autoimmune disease you struggle with, get deeper into it, figure out the cause, work with a functional medicine doctor. You can go to ifm.org and look in your area with a good functional medicine doctor. You can get my ebook. It's called the 10 Day Detox Autoimmune Solution. Give you a basic free framework of how to think
Starting point is 00:31:56 about it. And that's it for today's Health Bytes. I hope you enjoyed it. Be sure to share this with your friends and family on social media. I know so many people have, like I said, over 100 million people have autoimmune disease. And I think it would be helpful. Also, share with us how you dealt with your autoimmune disease. What have you learned? What's worked? What hasn't worked? What insights do you have?
Starting point is 00:32:14 We'd love to learn from you. And we'll see you next time on The Doctor's Pharmacy. Hey, everybody. It's Dr. Hyman. Thanks for tuning into The Doctor's Pharmacy. I hope you're loving this podcast. It's one of my favorite things to do and introducing you all the experts that I know and I love and that I've learned so much from. And I want to tell you about something else I'm
Starting point is 00:32:34 doing, which is called Mark's Picks. It's my weekly newsletter. And in it, I share my favorite stuff from foods to supplements, to gadgets, to tools to enhance your health. It's all the cool stuff that I use and that my team uses to optimize and enhance our health. And I'd love you to sign up for the weekly newsletter. I'll only send it to you once a week on Fridays. Nothing else, I promise. And all you do is go to drhyman.com forward slash pics to sign up. That's drhyman.com forward slash pics, P-I-C-K-S, and sign up for the newsletter and I'll share with you my favorite stuff that I use to enhance my health and get healthier and better and live younger longer. Hi, everyone. I hope you enjoyed this week's episode.
Starting point is 00:33:18 Just a reminder that this podcast is for educational purposes only. This podcast is not a substitute for professional care by a doctor or other qualified medical only. This podcast is not a substitute for professional care by a doctor or other qualified medical professional. This podcast is provided on the understanding that it does not constitute medical or other professional advice or services. If you're looking for help in your journey, seek out a qualified medical practitioner.
Starting point is 00:33:37 If you're looking for a functional medicine practitioner, you can visit ifm.org and search their Find a Practitioner database. It's important that you have someone in your corner who's trained, who's a licensed healthcare practitioner, and can help you make changes, especially when it comes to your health.

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