The Dr. Hyman Show - The Best Diet to Reverse Fatty Liver Disease | Dr. Yousef Elyaman

Episode Date: September 25, 2024

Fatty liver disease is on the rise, but the good news is, it’s preventable and reversible. In this episode, I sit down with Dr. Yousef Elyaman to explore the silent epidemic and how early detection could be the key to saving your liver—and your health. We break down the latest in diagnostic tools and dive into powerful lifestyle interventions. Whether you’ve been diagnosed or want to stay ahead of the game, this episode is packed with practical advice to protect your liver and your health. In this episode, we discuss: The importance of diagnosing fatty liver disease early through blood tests How dietary interventions, particularly the Mediterranean diet, can significantly improve or even reverse fatty liver disease Supplements that support liver function and reverse fatty liver disease How insulin resistance is a major contributor to fatty liver disease and why managing blood sugar levels is critical for liver health The connection between chronic inflammation and fatty liver disease How exposure to toxins and chemicals, including processed foods and environmental pollutants, contribute to liver damage and fatty liver disease View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman Sign Up for Dr. Hyman’s Weekly Longevity Journal This episode is brought to you by Rupa Health, BIOptimizers, LMNT, and Manukora Honey. Streamline your lab orders with Rupa Health. Access more than 3,500 specialty lab tests and register for a FREE live demo at RupaHealth.com. Tackle an overlooked root cause of stress with Magnesium Breakthrough. Visit Bioptimizers.com/Hyman and use code HYMAN10 to save 10%. LMNT is giving listeners a FREE eight-count sample pack of their vital electrolyte drink mix with any purchase. Just visit DrinkLMNT.com/Hyman today. Get your Manukora Honey Starter Kit today! Just head to Manukora.com/Hyman, to get $25 off.

Coming up on this episode of The Doctor's Pharmacy. When you have fatty liver, unfortunately, too many providers, too many doctors take a look at, say, oh, you have fatty liver, lose weight. They don't really talk to them about it again. When really that is driving heart disease, it's driving Alzheimer's disease, it's driving cancer. Hey, everyone, it's Dr. Mark. As a functional medicine professional, I'm always on the lookout for innovative solutions to improve patient care, and that's why I'm excited to introduce you to

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If you're looking for data about your biology, check out Function Health for real-time lab insights. If you're in need of deepening your knowledge around your health journey, check out my membership community, Hyman Hive. And if you're looking for curated and trusted supplements and health products for your routine, visit my website, Supplement Store, for a summary of my favorite and tested products. Welcome to the Doctor's Pharmacy. I'm Dr. Mark Hyman. I'm so excited to have our next guest up, which is Dr. Yosef Alamand, who's specialized in understanding a condition

that is affecting over a third of the world's population, and probably more than that in America, called fatty liver disease, but now it has a new name. We'll get into that in the show. But it's an epidemic that's driving huge amounts of disease, suffering, and we get into the details on the podcast of how this problem now affects over a third of us and why it's so prevalent, mostly related to our diet, to our gut, to environmental toxins. We talk about a traditional way of treating it, which is nothing. Basically, there's very few options from an internal medical care point of view. And we also talk about how to diagnose it. What are the things that you can do based on your traditional lab tests, based on maybe an upgraded lab panel, even ultrasound diagnostics that can help you decide if you need to do

something about this? Because fatty liver is a dangerous condition that drives heart disease, cancer, dementia, infertility, you name it, and it's invisible, it's symptomless, and it makes people really sick. But it's not something that your doctor is generally talking about or thinking about with you because there's no quick fix drug to give. We do talk about some promising medications that might be on the horizon, but we also talk about how to approach this through a functional medicine lens using diet and lifestyle, what you should be

eating, how you should exercise, what supplements can be helpful, and we dive deep into the science of what's happening when you get fatty liver disease. So I want you to make sure you tune into this episode and enjoy it. Well, welcome to the doctor's pharmacy. Dr. E, as your patients call you, it's great to have you. Thank you. Honor to be here. Well, you know, we are both part of the Institute for Functional Medicine and trained physicians and practitioners, how to think differently about disease and getting the root causes. And something you've been focused on lately, which I think is really important and something I really haven't seen a really good approach to from traditional medicine is what we used to call

fatty liver disease or non-alcoholic fatty liver disease. Because before there was just alcoholic fatty liver disease. Then we started eating all this sugar and crap. Then we have this epidemic of what was called non-alcoholic fatty liver disease. And they just changed the name to metabolic associated liver disease, because this is a metabolic nutritional problem. And the problem is in medicine, we've kind of neglected it because there were no good drugs. We like diseases with drugs. Oh, you got high cholesterol, I'll give you a statin. Oh, you got high blood pressure, I'll give you a blood pressure pill. Oh, you got whatever else you got, kidney failure,

I got the drugs for you. But if you actually have NAFLD, which we used to call non-alcoholic fatty liver disease, are now called MAFLD, there's really no great conventional medicine approaches to it, except liver transplant when things get really bad. And so you spent a lot of time focusing on this condition. I just want to give the background a little bit about this condition because it's so prevalent. I mean, think about something that affects over a third of the population of the world. We're talking about 2 billion people with a condition that is not a benign condition. It's causing huge amounts of suffering that is actually linked to all sorts of things, obviously like type 2 diabetes, heart disease, cancers,

gallstones, reflux, thyroid issues, kidney stones, depression, worse maternal and fetal outcomes, a huge increase in cardiovascular mortality, three and a half times the risk of heart failure, 1.93 times excess mortality from heart disease. This is a big problem. And traditional medicine, just like not that great at it. I remember working with one of the top hepatologists at Cleveland Clinic, and they were desperate

to have some solutions because all they could do was track the disease, follow the disease, give some people some general advice, hope it didn't progress. And then when it did, they need to go get a liver transplant. And here, this is one of the conditions that is really underdiagnosed, underappreciated. We're going to do a deep dive in talking about why this is important, why some of you walking around out there have this condition, don't even know it, and why you should care about it. And more importantly, that there are very specific things that you can do from a diet and lifestyle and even a functional medicine perspective that can work to not only slow this down, but to actually reverse this really pernicious condition, which has really been neglected by the traditional medical community.

But I'm glad to see there's more awareness and we're talking about it. I'm glad they changed the freaking name because why are we talking about non-alcoholic fatty liver disease? We're talking about the truth of it, which is it's a metabolic problem caused by our diet So you so tell me more about why why has this become such an issue? Why is it something that you know didn't really exist that much when I was in training Except been a bunch of alcoholics and now we're seeing, you know, 30% of the population globally having it and probably more in America I so I think when we were practicing, we kind of closed a blind eye to it. I think it existed. We'd always, I think you remember in residency, the incidental findings.

I think it was kind of like the gluten thing. I remember we never wanted to diagnose anyone with celiac disease because if we really didn't know what to do with it, we felt bad for patients. And once you actually take a look at it, you can come up with a solid plan. So the same thing with this, I think, from what I remember in internal medicine residency, we just kind of ignored it. And I think that now it's becoming a little more popular, partly because of the new drugs that they're developing. I mean, that's the reality. As soon as we have a drug for a condition, then that becomes something we promote, we advertise, we see ads on television.

But the amazing thing is, is that because we do functional medicine, taught by yourself and the other functional medicine founders here, but because we do functional medicine, we love the developing of these drugs because we understand the pathways. And we know how to modulate the pathway from a nutritional, nutraceutical kind of lifestyle point of view. Yeah. Yeah. So why do you think this is increasing? I mean, it clearly was there, obviously, when we were in training, but it's just exploded. We see 75% of the population is overweight, 42% are obese, 93.2% are metabolically unhealthy, which is essentially what this is, a metabolic associated fatty liver disease, right? So 93% of us have some metabolic

dysfunction. What's driving that? So one of the major things is food, right? So food and insulin resistance is kind of at the top of the list. So our food, there's more sugar being added to our foods. There's higher carbohydrates but when you when you look a little bit deeper into it high uric acid as well so that that comes from eating too much fructose fructose yes like high fructose corn syrup in all our food so we have high fructose corn syrup alcohol alcohol and is alcoholism is on the rise so alcohol is a toxin. So that also is going to affect the liver, along with small intestinal bacterial overgrowth. So bad bacteria in the gut.

The gut can be as metabolically active as the cytochrome P450. And because of our current lifestyles, the bacteria in our gut or in our intestines are changing. And they're changing for the worst. And there is an association between small intestinal bacterial overgrowth, which is one of the major causes of irritable bowel syndrome, and having fatty liver disease. That's when you're bloated and you get a food baby after eating. That bloating is because there's bacteria in your small intestine, which should not be there, that then ferment the food that you eat, particularly starches and carbohydrates, that then give off all kinds of toxic metabolites that can then poison your liver. That's what you're saying, right?

Absolutely. Right, right. Yeah. Yeah. What did you say? A food baby? Food baby. You know, that bloating thing that people get. Yeah. Right. Yeah. So one alarming statistic, they looked at young men that were not overweight. And they found that they did something called an insulin resistance score test on them. And they found that more than half of them had insulin resistance. And these are young men in their 20s, not overweight, normal ideal weight.

So I think that kind of brings us to one of the first drivers, which is this insulin resistance concept. Now, just to kind of back up on that, 20 year old men have prediabetes or some degree of insulin resistance, which is on the way to prediabetes. Yeah. Their blood sugar normal. And are they're measuring this by the new mass spec test from quest, which is a really new test. So, so just to back up on that, that there's a, the way we used to measure

insulin resistance in the lab was a euglycemic clamp test super complicated very difficult and we now you know have a new test that is equivalent to that um that surpasses the test we have been using which are just serum insulin levels and blood sugar and a1c and a glucose tolerance test which basically can give you a lot of information but this but this new technique of measuring C-peptide, which is sort of like the initial fragment of insulin and then insulin, using a technique called mass spectrometry through Quest, we can actually now be very, very good at predicting who has insulin resistance. And so insulin resistance seems to be the driver of fatty liver, correct?

It's a huge driver of fatty liver disease. It's, I would say it's the number one driver, but there are eight or nine drivers. But I, so what happens is, is that due to inflammation, due to toxicity, due to too much sugar, like too much of a sugar overload or a carbohydrate overload. When those receptors on our fat cells, we have these insulin receptors that are supposed to take sugar and put sugar into the cells. When they start to not work well, when they start to get resistant, there is an enzyme called hormone sensitive lipase. And what that enzyme does is it starts tearing up the fat in the fat cell and it sends the fat to the liver

and it overloads the liver. So now you have this liver that gets overloaded. So the liver ends up with a whole bunch of triglycerides, which is one of the tests that we look on the lipid panel now here's the interesting thing so you could check a triglyceride level and their level would look okay and that's because some people genetically will tear the will decrease triglycerides in the blood but what the triglycerides do, when you end up sending a whole bunch of triglycerides to the liver, they turn into something called VLDL. Very low-density lipoprotein.

Triglyceride-rich VLDL versus triglyceride-poor. And VLDL becomes, there's another enzyme found in the lining of our blood vessel that is that is called lipo protein lipase and it turns it into the tiny dense LDL which causes clogging of the blood vessel and heart disease strokes and heart attacks okay I'm gonna this is so juicy right here I'm just gonna unpack a little bit because basically you know just to kind of put things in context in France there's a delicacy called foie gras oh yeah yeah. Which I probably didn't pronounce right, but foie gras, whatever. And that means in French, fatty liver.

Yep. Now, most people think that if you eat fat, you get fat. And that fatty liver must be coming from all the fat we eat. But what you just said was that, in fact, it's not true that it's actually the sugar and refined starches and carbohydrates, the flour and the sugar that we're eating in pharmacologic doses, it's overloading our biology and causing that carbohydrates to turn into triglycerides, which then turns into fatty liver. And then you're in this vicious cycle where the fatty liver then creates all sorts of other

problems. So let's kind of unpack what happens biologically when you have a fatty liver. You get a fatty liver and so your liver's like looking like a fat goose or duck liver and you don't want to serve it on toast unless you're maybe Hannibal Lecter. And then you've got a process going on in that liver that's just more than the accumulation of fat. So what are the things are happening in the liver that end up causing harm? You mentioned that the type of cholesterol we get because of that fatty liver is the dangerous, small, dense cholesterol we talked about in the podcast. We did a whole podcast on cardiovascular risk and lipid analysis. So the small, dense cholesterol particles, which by the way, everybody listening, your doctor's not measuring when you go to get your cholesterol test. Less than 1% of cholesterol tests in America

are for the right cholesterol test, which is called lipoprotein fractionation. And it's looking at the particle size, the particle number, the VLDL numbers. And you can get all that, by the way, through functionhealth.com forward slash mark. It's a company I co-founded. It's a lot of people that get access to the right amount of information and data. So functionhealth.com forward slash mark. It's a company I co-founded. It's a lot of people that get access to the right amount of information and data. So functionhealth.com slash mark. You can get the right panel so you can see what's going on. And we also measure insulin, although soon we're going to be measuring this insulin resistance score, which is very exciting. Right, yeah.

What's happening in the liver? So what's happening in the liver? So we can go back to what's happening in the fat, and then go right back to the liver. So number one, the fat starts to send the triglycerides to the liver and start overloading the liver. When that process is overloaded, then your fat cells, which actually your fat is, I don't know if you've done a podcast on this but your fat is like an endocrine organ it makes things like adiponectin um uh your what when the process is bad adiponectin levels can go down which causes more insulin resistance and more inflammation and then there are other there there are other hormones that can go up in the liver that can cause inflammation,

like tumor necrosis factor, like leptin. So those go up, and now that inflammation and worsening insulin resistance and all that fat make its way throughout the body, and they go in the liver, and the liver starts to accumulate and accumulate and accumulate, and it just can't keep up with it. The liver packages it and sends it back to the fat. The fat takes it up, but then because of the insulin resistant, it shoots it right back to the liver and you end up with this vicious cycle. In the meantime,

the liver is not supposed to be storing fat. The liver is supposed to be making all these metabolic processes. It's supposed to repackage the fat and now when it gets overloaded and jam-packed Now the liver starts to get inflamed it starts to rust oxidative stress Sugar starts to get worse and it kind of creates this this metabolic nightmare. It's like a vicious cycle And and what you're saying essentially is it's both an endocrine and an immune organ. So all the hormones that regulate weight, appetite, insulin resistance, like leptin, adeninectin, these are hormones that the body produces to regulate your eating behavior and your way you process sugars and regulate inflammation. Like you said, tumor necrosis factor alpha or IL-6. These are cytokines. We heard about the cytokine storm.

So with a fatty liver, you're not just getting fat in there. You're getting this cytokine kind of increase that's driving systemic inflammation throughout the body, which it can explain a lot of the things we see with the increased rate of death and heart attacks and cancers and all these things that seem to be related to inflammation. Right. And see, and the thing is, I mean, we could just go, we could probably do a whole podcast on

when you have fatty liver, all of the other imbalances or all of the other things that are thrown off in the human body. Unfortunately, too many providers, too many doctors take a look at say, oh, you have fatty liver, lose and they move on and and they don't really talk to them about it again when really that is driving heart disease it's driving alzheimer's disease it's driving cancer yeah liver is supposed to be metabolizing our our toxins yeah so now you now your liver is not working it causes hormone imbalances the liver is supposed to metabolize estrogen so now you can't metabolize estrogen estrogen goes up progesterone goes down women start to have infertility issues infertility is big they start to have they start to have

mood issues they start to have they start storing more weight like they and men men start to get start to have that that estrogen effect it blocks their testosterone and it's kind of this it just it affects everything. It affects everything. Yeah. So men basically lose hair on their bodies. They grow man boobs. They have low sex drive, low testosterone. Right. Just from having a fatty liver. Right. Yeah. Right, right. So, so, so there's... That doesn't sound like fun. No, it's not. Well, I'll tell you, now that we have technology, the non-invasive, easily accessible technology to take a look at the liver, when we tell people that their liver has fat in it, or there's an issue with their liver, I have not seen a more motivating driver

of change. As a matter of fact, when I see liver enzymes being up, I had a patient who I talked to her about, she had elevated liver enzymes. I said, I wanna take a look at your liver. I sent her to do this test, it's called a FibroScan. Before she came back, she had lost, she stopped drinking alcohol and she had lost 20 pounds. And yeah, it came back. Her liver was fine.

But what happened when people hear that their liver, there's a problem with their liver for some reason, it creates that motivation. Yeah. Which I can tell them, hey, you're going to die of a heart attack and it doesn't, yeah. Yeah, it's interesting. But I think what you just pointed to is something really important,

which is that this is a condition that's so prevalent, affects at least a third of Americans, that is underdiagnosed, and that is as big a risk factor for having a heart attack as anything else, right? Like the level of magnitude of the risk of having a fatty liver for death, heart attacks, cancer, is extremely high. Right. Do you have some of the data on that? Right. Yeah, we could put them in, we can post them in the heart attack. Yeah. Yeah. We could put them in the show notes, the percentages. Yeah. It's really significant. And when I started reading about fatty liver

years ago, I was like, wow, this is in and of itself a huge problem because it's driving all these other diseases that we're treating separately, but we should actually be treating the liver. Let me ask you a question. What do you reach for after you finish a workout? If you're like most people, you probably reach for a sports drink to replenish the water and electrolytes you lost. That's great, except that most of these drinks are also filled with sugar, food coloring, and other junk. When I want to get the benefits of a sports drink without all the nasty stuff, I reach for Element. Their tasty drink mix has everything I need to give myself a science-backed electrolyte boost whenever I need it. And there's no sugar, coloring, artificial ingredients, gluten, or fillers, which means it aligns perfectly with my dietary choices.

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with superpowers from Manukora. In the conventional realm, unfortunately, we try to look at the disease kind of in a vacuum, right? Okay, so you have fatty liver. So what can fatty liver do? Well, the liver can start getting inflamed, and then it can start to turn into fibrosis or hardening, and then you can get cirrhosis, right? And nobody wants liver cirrhosis, right? Most people know that liver cirrhosis is a bad thing, and then you can get cirrhosis, right? And nobody wants liver cirrhosis, right? Liver cirrhosis, most people know that liver cirrhosis is a bad thing and then you can also get liver cancer. But like you just mentioned, they have more of a chance of dying of a heart attack than of the liver cirrhosis when they have fatty liver.

So I think that's what you were alluding to. Yeah, yeah, yeah. Yeah, so it's so, but I think the beautiful thing and I'm so fortunate or grateful that I found functional medicine because we don't look at fatty liver as a disease in itself. We say there is a process that is happening. Part of a syndrome that's happening. Part of a syndrome.

And everybody is unique on what's causing it because some people, it's insulin resistance. Some people are eating lots of the way that their body deals with fructose. They start to increase uric acid, and it's the uric acid that is driving it, where other people can have thyroid dysfunction that's causing it. And others can have an issue with bad bacteria in the gut. Yeah, so other people have a iron overload that is causing it. And others were exposed to different toxins. And it's probably a combination of a whole lot of things.

Yeah, I mean, I think this is really important. I just wanna pause there because from a traditional medicine point of view, it's like, okay, you okay, we do a blood test, we do a fiber scan or MRI, we look at your liver, we do a biopsy, okay, you have fatty liver disease. But the why is very much neglected. And there is some understanding

that it's due to a high refined carbohydrate diet. And yes, people understand hemochromatosis and iron overload, but the fact that the microbiome's involved, the environmental toxins are involved, that it may be thyroid dysfunction, that there's a whole list of causes. And that's really where functional medicine is different than traditional medicine. It's root cause medicine that is ruthless around investigating the causes of a condition so that you can treat that person as an individual rather than treating everybody

who's got this condition the same, right? If someone, there was a thing I read about years ago, it was a scientific paper about a guy who had liver failure, but he was a golfer. And, you know, usually golfers, I'm not a golfer, but apparently they have to clean their balls and there's this ball cleaning thing on the golf course to get the dirt off, but he used to lick the balls to clean them. But there's pesticides all over the golf course.

So he was getting, he was getting toxic pesticide load in his liver and caused him to have liver failure. So, so we have to think about all the root causes and that's where functional medicine helps us to navigate. And then the gut role plays a huge thing too. And we don't really think about addressing the gut, but we know, we know that how, how big a role the gut plays in, in, in affecting our metabolic health and our, our, our load of toxins. And I mean, in medical school, we used to treat liver failure with, which resulted, you know, in the inability to metabolize toxins from the gut, which caused basically delirium, something called hepatic encephalopathy. We treat it with an antibiotic and a laxative, so basically to sterilize the gut, get rid

of the bacteria that were poisoning the body, which is interesting because now we understand the microbiome has a huge role in mental health. But that was something we learned, and it didn't really kind of connect with us in terms of a thing understand the microbiome has a huge role in mental health, but that was something we learned, and it didn't really kind of connect with us in terms of a thing about the microbiome in medical school. Right, right. It's a prebiotic. Lactulose is a prebiotic.

Yeah. So you're feeding the good bacteria. Yeah. So we were manipulating the microbiome, and we thought we were just making them poop. Yeah. And it was amazing. It would take them out of that hepatic encephalopathy.

Yeah. So basically what's going on in the liver And it was amazing. It would take them out of that hepatic encephalopathy. So basically what's going on in the liver is you've got a number of different things that are happening in our society, which is no overload of toxins, which is obviously our diet, which other factors that you mentioned, the gut microbiome changing dramatically, all driving this epidemic of fatty liver disease. And now there's sort of an interest in kind of addressing this more directly in the medical field. We renamed the disease from non-alcoholic fatty liver disease to metabolic associated fatty liver disease. And actually it changed that.

So they first went to metabolic associated liver disease, then they changed it again because they, yeah, whoever they are are the big panels actually multiple panels got together and they talked to patients but I think we should talk about that story a little bit right so non-alcoholic fatty liver disease was basically your naming condition by saying what it was not yeah it's not alcoholic right like it was kind of weird anyway even though that it was called non-alcoholic fatty liver disease they people associated with alcohol right because alcohol was in the name and then they have to explain it to their family right i'm telling you it's non-alcoholic right right so that you had that negative and then the fatty had a stigma so

they changed it to metabolic associated or metabolic dysfunction associated if I deliver disease but then they changed it again because they're like fatty is stigmatizing so we don't we want fat out of it so now it's metabolic dysfunction associated stats to stay attic stay stay attic which means fat liver disease so that So no, steatic liver disease. So now you took everything out that anybody could understand. So you put a medical term in which means fat, which is steatosis, which means fatty.

Right, right. But now they don't get shamed. Now it's in Latin, so it's okay. Yeah, that's fancy. That's fancy. Whatever. So that's the problem. In medicine, we call it the naming and blaming game.

We name the disease and we blame the name for the problem. Why in the world do you have that abnormal liver function. Now it's called mazled. Mazled. Mazled. Okay, forget about what it was called. We know this is a bad thing. We know it's increasing.

And we know that traditional medicine doesn't have a great approach. So I want to walk through how traditional medicine approaches this and then how we're going to approach this with a new perspective of root cause medicine and functional medicine and then how we go about looking at the diagnostic tools we have to assess it and what are the therapeutic tools. So just sort of high level, what if you want to see a traditional hepatologist, you have fatty liver, what are they going to tell you? What are they going to tell you to do? Okay, so you go to a traditional hepatologist. It's a liver specialist.

A liver specialist. They see the patient they tell the patient you have fatty liver disease go ahead and try to lose weight right they may give them vitamin E probably are you gonna give them the wrong kind of vitamin E because and we know that there's different forms of vitamin E and then and then if you're lucky many will say no don't stay away from vitamin E and then they see if you're bad enough to be enrolled in a study. And if you, and if,

if you are, then they'll put you on a drug, right? If not, because there's no FDA approved drugs for fatty liver. There is one now. We just in, in,

in March, we have one called resmedirom and we could probably, we should probably unpackage that later. Let's come back to that. Yeah. But yes, so there's finally one drug. It costs only $4,000 a month. Is that it?

Yeah, that's it. And it can cause all kinds of side effects as well. Great. But that being said, it's all about getting them, okay, we have a disease. We named it, right? We need to tame it with a particular drug. But up until March, before that, what would they be telling you? Some would say, ask your doctor if he would prescribe semaglutide for you.

Ozempic. Ozempic. That's currently what they'll tell you. For weight loss, because when you lose weight, fatty liver gets better. Right. So what would we do? We would take a look at the Fibro score. And I do want to talk about this FibroScore because this is – or the FibroScan because this is extremely – But back to the traditional medicine. Are they thinking that this is really diet-related? Are they thinking that we should cut back on carbohydrates and starches and sugars? No particular diet. Do they really talk about a keto diet or anything like that to help?

Traditional medicine is like lose weight. Lose weight. Just lose weight, eat less, exercise more, come back in three months. And if it doesn't work, we'll put you on drugs. Except, oops, there's no drugs for this. Yes. Unfortunately, we don't. So semi-glutide. Okay. I was that big. All right. And then? Yeah. And that's it. And then they just kind of leave you there. And most of them are not getting a fibro scan. Most of them don't know how bad it is. They don't know if they have fibrosis, which is hardening or not.

And they just kind of wait till things get really bad. And they might, if you're diabetic, which is associated a lot with diabetes, right? Because it's sort of the same condition, but earlier on. And they might give you metformin or they'll give you the Ozempic or maybe some of the- Although metformin hasn't been give you the ozempic or maybe some of the the although metformin hasn't been found to decrease fatty liver disease it's it's kind of but but they may give you that they

definitely will say you have a high risk of of heart disease so make sure you're on a statin drug so they will put you on a statin drug and and and the problem is it's a double-edged sword the statin drug can cause liver toxicity but also it can can change the way the lipid metabolism. So you know you may be hurting the liver, but you may be helping the heart, right? So it's kind of one of those. And then if you're overweight enough, they'll say, why don't you have bariatric surgery, gastric bypass? So clearly, traditional medicine has not developed a good approach to this yet. And let's talk about the diagnosis part, because now there's some interesting new diagnostic tests.

You just have to do a liver biopsy. It was an invasive procedure. It's risky. Nobody wants to get a liver biopsy. It was expensive. Now there's some blood work you can do and some ultrasound technology that you can use to really diagnose what's going on. So talk to us about how people can find out.

I don't know. I have fatty liver disease. What do I do? I think the best thing to do is get a fibro scan. A fibro scan is ultrasound technology, and it's very quick, it's non-invasive, and they give you two numbers, something called a CAP score and a fibrosis score. The CAP score tells you what percentage of your liver is fat, and the fibrosis score is how much hardening there is in your liver. The cap score tells you what percentage of your liver is fat. And the fibrosis score is how much hardening there is in your liver. The beautiful thing about that is before we had no

idea how bad it was. And now I can give them a number. I could say around 35% of your liver is fat right now. I can put them on some sort of a plan and I can retest it and I can see it get better. And that is profound versus, oh yeah, you still have fatty liver disease. Oh, the ultrasound shows you have fatty liver disease. Or the ultrasound show you don't have fatty liver disease, but they do have fatty liver disease because ultrasound isn't sensitive enough to pick it up. So that is a game changer. And just to be clear, the first step is your liver gets fatty, and then it gets inflamed, and then it gets scarred, and then you have cirrhosis and then

you need a liver transplant right right right but some people go right from fatty without the inflamed they go for right from fatty to scarred yeah so some people do skip that step yeah you think everything is good and then they end up so so but not everybody's going to get a fiber scan so are there blood tests that will clue you into maybe you need one, right? There are. There are. So, we talked about, so the problem, if they have high triglycerides, or if they have insulin resistance, or if they have high blood sugar, so if they have any of those things, there's

a high probability that they have fatty liver. So if you have a high blood sugar, if you have high triglycerides, low HDL, and maybe a high hemoglobin A1C, like over 5 point whatever, 5, 7? Yeah, 4. 4 or 5? Yeah. So as all those numbers start to creep up, and these are things you can get on a regular blood panel.

Yes. The lipoprotein fractionation is more predictive. Yes. And that's a better test. And we do that with a function health panel. The lipoprotein fractionation is more predictive and that's a better test. And we do that with a function health panel. So you go to functionhealth.com, you can get all these diagnostic tests for 4.99 for membership and do it twice a year and track stuff over time. And if you track these numbers, you can see that you're at risk. And maybe you'll have not only just that, you'll have elevated liver function test, right? So you might small density ldl so the problem with triglycerides is some people have a high amount of what's called it's an enzyme called hepatic lipase so it takes it lowers their serum triglyceride levels but they have high small density ldl so small density ldl when that's

elevated that tiny tiny bad cholesterol that you check thing. That's the thing. That's the thing. That's the thing. That's the thing. That's the thing. That's the thing. That's the thing. That's the thing. That's the thing. That's the thing. That's the thing.

That's the thing. That's the thing. That's the thing. That's the thing. That's the thing. That's the thing. That's the thing. That's the thing.

That's the thing. That's the thing. That's the thing. That's the thing. That's the thing. That's the thing. That's the thing. disease are very high. That's what I'll use as a marker. So you can track your small LDL particles. You track it as it's getting better, their fatty liver disease is getting better. That's been proven too. And yeah, and I encourage people to go back and listen to the podcast I did on cholesterol and cardiovascular. I talk about

all these diagnostic markers that are not used in traditional medicine that should be, including this lipoprotein fractionation. So these tests are super inexpensive, super easy to do, but they don't tell the full story. So there's a newer kind of interpolation of a number of different biomarkers that are used, basically your ALT, AST, liver function, plus platelets, plus your age. And you get something called what? A FIB4.

A FIB4 score. So this FIB4 score you can get through Quest. I don't know if LabCorp does it. And you get this score that gives you a sense of, gee, I might be having fatty liver disease, right? Right. And anybody, so like you said, they're looking at platelets and they're looking at AST and ALT, which are found, those things are found in regular blood work your doctor does. so if they didn't CBC in a chem panel it's like basically your annual checkup will handle checkup stuff now if they didn't add the the the fib score to it the fib for there's fib for

calculators you put that you put the numbers in the calculator and it'll give you the fib for now here's the thing about the fib for it really the young under 30 age 35 and older than age 65, it's not as accurate. But what is it really telling us? It's telling us a, it's a predictor for hardening of the liver. Your liver could be jam packed. You could, your liver could be the human foie gras, right? But if, if, if it's not picking, if you don't have fibrosis, it's not going to show anything.

I see. So you go, this is only in the later stages that you're going to see this test be elevated, right? So you might see the clues with the high triglycerides, high insulin, high glucose, small particles of LDL, but you might not see the FIB4 score up until you're already down the road a bit. Right. And just pointing out those levels, the ALT and AST. So those are called liver function tests. They're really enzymes that the liver has in them. The data is showing that those numbers are supposed to be lower. So ALT- The reference ranges that we have. Yep. It's supposed to be less than 30, women less than 20, right?

And the reference ranges in the lab are like 40 or 50, right? Right, they're up there. The other thing is, so what are they looking at? Why would that FIB4, why would they be looking at platelets? Well, it turns out that the liver makes a hormone called thrombopoietin. And if you get hardening of the liver, it can't make thrombopoietin. So now your platelet levels start to go down. But drinking alcohol poisons the bone marrow, and that lowers your platelets.

So if they're actively drinking alcohol, it could falsely elevate it. But it also can cause liver disease too. So basically, the regular blood tests you can get can tell you a lot. We're going to put all this in the show notes. You have to remember, you can get the Function Health panel at functionhealth.com forward slash mark that gives you all of that, except it doesn't calculate the FIB4 score, but you can do it because all the data is there.

But there's another test that they do if this FIB4 score is elevated called an ELF test. So can you talk about the ELF test? Because it's a little more advanced and what it is and what it means and who should be doing it. Right. So the ELF test is also a marker of fibrosis. So what they do,

there's three different, what we call biomarkers, or three different lab levels that can indicate that the liver is getting hard or getting that fibrosis, and you can end up with a score there. And it's much more accurate. It's maybe 80 to 90% versus around 45%.

Because the first PIP4 is just sort of interpolating from existing biomarkers. It is. This is actually looking for compounds or molecules that are elevated when there's a fatty liver or liver fibrosis, right? Right. It's going to miss more. Like hyaluronic acid, type 3 pro-collagen peptides, tissue inhibitor of matrix, metalloproteinase. These are all kind of big fancy medical words, but the things you can get on a blood test that are not your typical blood test. So you've got your doctor will have to ask for

this. Or if you have a FIB4 score that's high, you can go say, I want this. Right. And this is where we, I think this is where the podcast today changes the world, right? Be aware, be aware that you could have fatty liver. See if you can get a fibro scan, because places are popping up left and right. And if you do-

But your doctor has to order that. Yes, or you can go, there are certain places that are trying to study medication where you just go get it for free. There's like research centers. So look for a fibro scan near you. This may be worth paying self-pay for, but once you see that you have that fatty liver

disease, reverse it before that FIB4 is high, before the ELFF is high before the fibrosis. This is where, this is where I think if we can catch this thing early, we can, we can make a significant impact on, on the health of the planet. And so the elf, what you're thinking is the elf test, essentially this, this other test is, is really just picking up scarring, right? Not necessarily just fatty liver. And as a primary care doctor, when I see somebody with an elevated elf,, because we'll see the FIB4 high, and that could just be a false positive. I'll check an ELF. I'll check a fibroscan. And if I see a high fibrosis in them, I'm going to be co-managing

them with a hepatologist. I'm going to be more aggressive, but that's where it needs to go in the specialist. But like you said, with the amount of, the percentage of the world that has fatty liver disease, we don't have enough hepatologists. We are not going to. But I'm just gonna push back on you, because even if you send them to a hepatologist, what are they going to tell them? No, they're gonna hold their hand

as they need a transplant. Well, that's exactly right. I mean, that's exactly right. That's the conversation I had with the amazing man who was the chief of hepatology at Cleveland Clinic. Right. We just don't have a lot to offer them. Could you help us?

And how do we start to get these patients to change their lifestyle and behavior? So basically the bottom line is there's some great diagnostics on your regular blood panel. Right. We'll put those in the show notes. There's some newer tests that you can get on blood work that can help. There's a great ultrasound that's not very expensive, non-invasive, and has no risk that you can get on blood work, blood work that can help. There's a great ultrasound. It's not very expensive, non-invasive and has no

risk that you can get to see what's going on. If, if you have a potential elevations in any of these numbers or you're overweight, you're at risk, even if you're not overweight, maybe you could be not overweight and be what we call a skinny fat person where you're metabolically obese, normal weight, because you eat crap and you're not, you don't gain weight, but you have fat on the inside. Right. But then

you do all these great diagnostics and then what? Because there's no real treatment for it in traditional medicine. So from a functional medicine perspective, how do you see this epidemic? What, what can be done about it in a practical way to help people reverse it? We now know sort of how we can get it diagnosed. How do we start to think about it differently from a functional medicine? Right. And this is where conventional medicine and functional medicine is going to be different. Conventional medicine says just lose fat, right?

They studied it. They looked at whether low carb was helpful, high protein, whether a keto diet. Believe it or not, if you go on a keto diet and you lose weight, it will reverse this, even though you're eating fat, like you mentioned early on. What we're looking for is what is it that regardless of whether they lose weight or not, what will reverse this, right? So Mediterranean food plan. There was data that showed that the Mediterranean food plan, which we which we pizza and pasta. Yes, yes. No, no, no, no. So it's, it's, um, it's, it's a heart healthy food plan that where they took a look at the healthy foods that people that lived in the Mediterranean high in olive oil, high in vegetables, um, high in those foods. And they found the significant benefits benefit benefit with mood, benefit with metabolic disease, but also

independent of weight loss. If you go on a modified metabolic food plan, you will end up seeing an improvement. And IFM, the Institute for Functional Medicine has one that they call the cardiometabolic food plan. And that's what I give all of my patients. Say, let's start here, the cardiometabolic food plan. Also, you i give all of my patients say let's start here the cardiometabolic food plan also you could have food allergies that is pushing this for example gluten right you could he some people have fatty liver disease because they're eating a food that is bothering them and inflaming them and you get them off the gluten or get them off the dairy or whatnot and because anything that causes inflammation will cause insulin resistance so it's kind of the mechanism is well known there right decreasing fried foods because fried foods have something

and glycosylation end products which uh when you fry fry foods sugar with other molecules at high temperatures it causes what's these toxins these end glycosylation N-products, and they will cause inflammation, something called oxidative stress, which is rusting, which worsens the condition. So decreasing those is extremely important. And also sugar, flour, fried foods. So I think everybody talks about the glucose, but we're not talking about the fructose piece right fructose if you look at high fructose corn syrup or just regular table sugar it has sucrose and it has fructose fructose pushes the body to make uric acid and and uric acid tells the body store fat so it slows your metabolism it tells people to store fat and it And it worsens fatty liver disease.

And I believe you did a podcast on this. Richard Johnson. Yeah, people should go back and listen to that. We'll put the show notes on that. Because uric acid is a consequence of really eating a poor diet, particularly one that's high in high fructose corn syrup. And back to optimal levels. So according to Dr. Johnson, and this is what i go by five you want your uric acid level less than 5.5 right right whereas whereas the the labs is about seven eight yeah seven eight

something like that and and when they see that uric acid high there are supplements that you can give them and there's also there's also uh dietary changes there's cherry extract for that it's great for gout and high uric acid high dose of cherry cherry dark cherry extract vitamin c quercetin maybe some green tea those things all can help lower it so if you have somebody that has stopped drinking the two liter bottle of coca-cola with 75 percent fructose and 25 percent so So if you have no, absolutely, sodas are going to really drive it. So you'd follow that glucose and insulin resistance score. If your sugar is already high when it's fasting, that's your main, you got to work. There's some work. If you just have

insulin resistance, that's still a problem. So with insulin resistance, there's things like berberine that can help. There's things like with alpha lipoic acid and acetylcysteine that can help. So yes, Mediterranean food plan, exercise, whether it's resistant training or cardiovascular training, both independent of weight loss will reverse fatty liver disease. So you can exercise and you can stay the same exact weight and you can still have that fat start to reverse. Because it makes you more insulin sensitive. It makes you more insulin sensitive.

I mean, this reminds me of an interesting study I read years ago where they did bariatric surgery. And basically when you do bariatric surgery, you can reverse diabetes in like two weeks and reverse the fatty liver in a very short time. And yet they're still severely obese. Like someone can still be 400 pounds, maybe they lost 25 pounds, but they're still 375 pounds and diabetes goes away like that and fatty liver will improve

because you're changing the food. And changing metabolism at one point the heaviest man in the world actually had had um his his blood sugar was normal and it was because of such a high adiponectin level so so so there there is the genetic factor but there's also the metabolism and the way that the body um um uh decreased sitting of course increasing steps things like that so we get them exercising and i think i think the most important thing and if you mentioned this a couple of times is that we got it we we we really want to be careful of the

catastrophic black and black and white thinking like oh if you don't lose weight that's it because there are so many things that you can do besides that we meet people where they're at and you don't not, not everybody's going to be able to do that. You can go on a medicine like semaglutide or like you said, Ozempic, and it could end up losing their muscle. And then what is it going to do? We see all kinds of side effects with that, with that medicine. Yeah, you get more insufficiency when you lose muscle. You know, it's interesting. So, so just getting back to the diet part, because I think there's a lot of ways to skin a cat. You mentioned just a Mediterranean diet, which essentially is fruits and vegetables, protein, nuts and seeds, olive oil, healthy food, real food, not pizza and pasta. Right. Cut out the fried foods.

Yeah, cut out the fried foods. And so that's good. But do you need to be more aggressive sometimes in terms of cutting out more starches, like cutting out grains or beans or fruit? Because if we mention fructose, people are like, oh, fructose is bad. Does that mean fruit is bad? Because that's where fructose is found. So fructose is bad when it's in high amounts in a way that it wasn't found in nature. So in the form of a juice, not so good for you. In the form of a fruit, the fruit actually has the antidote in it.

So when you get it as a balanced thing, it's not. Fiber is the antidote. Fiber is the antidote. Plus it has all the different colors of the fruits and vegetables have what they're called. Antioxidants. Yeah, phytonutrients. And the phytonutrients actually will counteract and decrease uric acid. So, but I think it all depends if somebody is is in the beginning they're excited

they're ready they're ready to do whatever it takes yes you cut the sugar you increase the you increase the healthy foods but meeting people where they're at we got we have to be careful of the all or none thinking because what will happen is they'll say oh shoot I ate too much sugar so screw it I'm just going to eat a candy bar, right? And I'm not gonna do this anymore. And that's why, no, no, no, why don't we focus on what you should be eating, or what you wanna be eating? Why don't you, okay, have maybe two servings of vegetables with that Snickers bar, right?

So I might not just say Snickers, I don't know, but... You can say whatever you want. Okay. But wow. So given that, um, given that you're trying to meet people where they are and help them not be overwhelmed and make the simple small steps that you can see that could make a big difference. But if you had a perfectly compliant patient and you wanted to create the fastest results to reverse fatty liver, what would you do? Would you put them on a ketogenic diet? Would you put them on a paleo diet? Would you put them on a vegan diet? What would you do? Mediterranean. That would be the

Mediterranean, the cardiometabolic food plan. So even with option of really reducing the carbs even more? Reducing the carbs even more is logical, but now we have to look at the research we have available. And the research did show all of those diets that you mentioned are food, I like calling them food plans, but all of them will help with fatty liver. But the one that has been shown that reduces, that will decrease fatty liver, but independent of weight loss is the Mediterranean. And that's why I think that should be the big, but do I have people that go low carb and keto and it works? Absolutely. So no, that all intuitively, yeah,

you cut the sugar, insulin resistance improves. But I think that the focus on Mediterranean is, is you're, you're focusing on healthy fats, which is something that you're a proponent of, right? You're also focusing on the fruits and vegetables. Those colors are, they're medicines. They're medicines. So to tell them to just eat a bunch of steak and forget about the phytonutrients. Phytochemicals is key. Because those phytochemicals actually are active as support for liver detoxification and inflammation. You know, one study I read years ago was a mouse study, and they gave mice alcohol, and then they watched what happened and developed fatty liver. And then they, they gave them alcohol plus high, relatively high

amounts of MCT oil, which is a medium change triglycerides. And it comes from coconut oil and other places, but it's, it seemed to actually reverse it. Can you explain that? Yeah. So, so if you, if you increase, um, um, what does MCT oil become? Ketobuterate? Ketobuterate? Yeah. It increases, yes. It's metabolized and absorbed differently than traditional fats. So it's absorbed directly into the body. It doesn't have to go through. Right, right. So, and you can use that as a fuel, which increases your efficiency, which D of which of your receptors and decreases insulin resistance. I know that I know that omegas are fish oils. One of the things that fish oils does is is it so healthy fats, if you give people healthy fats, phosphatidylcholine helps as well. It blocks some of those triglycerides from going back into the liver. So it kind of stops the liver from getting overloaded as fast. So I wonder if the MCT oil works by that mechanism. Yeah, it was fascinating.

I was like, wow, you could even be drinking a fish and take the MCT oil, and it would mitigate the damage to your liver, which I thought was interesting. Right, but I do work at the guest house, which is Substance Abuse and Trauma Center. So we're not like proponents of drinking like a fish. No, of course, of course not. I'm not saying drink and take MCTL and cure your brain. I'm not saying that, just to be clear. So just to back up a little bit about what you were talking about, diet's key. So cutting out the free fructose in high fructose corn syrup, just get rid of that 100% from your diet, number one. Number two, increase a diet that's high in phytochemicals, high in fiber, high in good fats, nuts and seeds,

lots of fruits and vegetables, clean protein, some whole grains, beans can be fine, right? Alcohol, stop the alcohol. Stop the alcohol, stop the sugar, stop the Tylenol. Stop the Tylenol. Because Tylenol is a liver poison. And then you talked about exercise being really instrumental, so that's clear, and I think everybody understands that.

And you mentioned a bunch of supplements. So I want to kind of go down that rabbit hole with you because I find that using things that help support liver function can be extremely effective, and it's actually in the published medical literature. In fact, one of the things we use for liver failure, when people overdose with Tylenol, when they come into the emergency room,

is something called mucrimist. Now, I thought that was a drug, because that's what I learned in medical school. But it's actually N-acetylcysteine, or a supplement, that gets turned into glutathione. And that rescues the liver from catastrophic liver failure. And it's just a supplement. Right.

Now, the FDA is trying to take it off the market because it works so well. But it's something you can take to boost your levels of glutathione. Yes. Which is the body's main repair, antioxidant, anti-inflammatory system. Right. So you mentioned that. What other supplements are in your top five or six supplements? So I'd like to just elaborate a little bit on them right so the that NAC

and acetylcysteine increases glutathione glutathione is an anti rusting agent right we check a level in the blood called GGT GGT tells me that you've been using up a bunch of glutathione and you have rust happening. If it's elevated. If it's elevated. So if they have elevated, if they have an elevated liver enzyme or if the ALT, AST or elevated GGT, I'm going to be giving them, I'm going to want to give them the N-acetylcysteine. The other thing is, is if they have an elevated GGT, that is an independent risk factor for fibrosis. So if you have high GGT there's a high chance that you have fibrosis as well and the supplement that has been found to help is CoQ10. And I give

the ubiquinol form, the unrusted form. So I don't know if you, I know there's debates back and forth as does it matter if it's ubiquinol or ubiquinone, but there is data that supports giving ubiquinol with a high GGT can lower that GGT. And GGT can also be a clue of environmental toxic load too, not just fatty liver. So we're talking about other causes besides just diet. Right. The triad, elevated liver enzymes, higher than the optimal level, high uric acid plus high ggt if you have those that and and they're not they're they're not moving they're not budging you have toxic overload they need to read your book on your your detox book yeah i mean and that and that's something that people can can

learn how to do and i think and can remove some of the environmental toxins that can be loading the liver and just reduce their exposure i mean i was reading the other day that the average american has 22 pounds of food additives every year yeah what's that doing it has to go through the liver right yeah it's not great so so so there's already there's a couple of supplements right there's research that showed that vitamin E was helpful. Now, here's the challenge with vitamin E. The vitamin E that is normally pushed at the store, at the supermarket, is called D-alpha-tocopherol. It is synthetic, right?

It's not the way it's found in nature. In nature, there's eight forms of vitamin E. Alpha, beta, delta, gamma-tocopherol. Alpha, beta, delta, gamma-tocopherol, alpha, beta, delta, gamma-tocotrienol. And if you start hitting the body with just one type and the synthetic form, what we think- It becomes more oxidized. Well, more oxidized and it may be stopping

the other forms from getting in. Yeah. So you're creating a vitamin E deficiency by giving them vitamin E. Yeah, so what you get at your local drugstore is probably not the right form. So I switched. We're going to link, we're going to link to the right forms that contain multiple

forms of mixed, mixed tocotrienols, which we call. The research that showed improvement in fatty liver actually showed the mixed. Right. There is a supplement called phosphatidylcholine. Yeah. And that stops some of the bad fats from getting into the liver and choline helps process fat. So phosphatidylcholine, I've been impressed with it. I've seen it work really well decreasing that fat.

It also detoxifies, you know, cell membranes. I actually recently did a test. We're here at the annual International Conference for Functional Medicine and I gave a little presentation yesterday and I shared my own case history of my illness when I was 36 and chronic fatigue and being overloaded with mercury and mole toxins and everything. And I actually did this test recently that's from Germany that looks at your cell membrane levels of toxins.

And I had, you know, mole toxins, pesticides, you know, plastics, heavy metal. I mean, you name it, I had it. And I did a course of intravenous phosphatidylcholine over the course of 10 weeks, twice a week, about 10 grams a time. So it's like 2000 grams, which is a kilo basically over time.

And I redid my test and I was shocked to see that the levels of the toxins drop dramatically, almost to normal by repopulating my cell membranes with a better, newer form of the fat. So all our cell membranes are made of a phosphocholine and it helps to detoxify our liver. So I think that this phosphocholine can be helpful in many ways. And I think you can take it orally, you can do it intravenously. I want to back up a little bit because you were talking about these tests, you know, uric acid, GGT, and all these other lipoprotein fractionations. Typically, when you go to the doctor for an anal checkup,

they're not checking uric acid, they're not checking GGT, they're not checking insulin, they're not checking lipoprotein fractionation. So these are available through Quest or LabCorp. They're really easy to get, and they're not that expensive. In fact, with Function Health, sorry to harp on this, but you can get all these tests and lots more for, you know, $499 membership for twice your testing and track your numbers over time

and sort of have a health copilot that tells you what it means and what to do about it. It's so important to know what's going on in your body because, you know, most medicine waits till you have a serious problem and then they come in kind of to rescue you and treat it. They don't see the subtle, slow changes that you can pick up as clues in your blood work

early on that you have to know because if you don't do it, you know, like I said, 30% of Americans or more are walking around with this problem. It's invisible. It's painless. It has no symptoms, that is extremely risky for a whole range of chronic diseases, including heart attacks, cancer, stroke, dementia, and more, infertility, whatever, and it's just not being diagnosed. So I encourage you all to just get checked. Tests don't guess.

Now, in terms of the next set of supplements, we've got N-acetylcysteine, we've got vitamin E, but the right form of mixed tocopherols, and I'll link to that in the show notes of what would be the optimal forms to get. What else should people be thinking about? And CoQ10, right? And CoQ10, and the right form, ubiquinol. If it's an oxidative stress thing that we're working on,

then you can consider things like alpha lipoic acid as well. It's a powerful antioxidant as well, and it can help lower sugar for insulin resistance. So those, I would, we already kind of talked about the high uric acid. If your uric acid is higher than 5.5 in a postmenopausal woman or in a man or in a a a woman that that does that is having periods it should be less than 4.5 so if that uric acid is high you already mentioned the the dark cherry extract you you mentioned uh we we also talked about quercetin quercetin helps with multiple things what does that do so it's a mass cell stabilizer but it helps the body excrete uric acid do? So it's a mast cell stabilizer, but it helps the body excrete uric acid.

So it's basically from plants, right? Onions and berries and different things. Apples. And it turned out to be very effective in COVID. It's great for longevity. And there's a lot of research on quercetin. It's in Himalayan tartary buckwheat at high levels, which is something that we talked about on the podcast before with Jeff Bland, that is really showing the immunorejuvenating properties and actually reversing biological age.

So I think this is a very important supplement that most people probably don't know of, but has many, many effects. It works also on AMPK, which is one of the longevity switches that regulates insulin resistance. So it has so many benefits, but in terms of fatty liver specifically, it can help lower uric acid and help improve fatty liver. And may lower iron because the liver starts to accumulate iron, whether you have hemochromatosis or not, you can start accumulate iron. So that's milk thistle. So then there's another one. Yeah. Milk thistle. Silamere. So what does that do? So that helps with detoxification as well, but also may lower iron. And inflammation helps with liver inflammation.

What about minerals and vitamins like selenium and things like that? So now when we start looking at liver function, one of the tests that I like looking at is a homocysteine. Because if your homocysteine is high, then the way that you're processing some of the B vitamins is off. And then you get a backup in detoxification, so your body can't get rid of toxins. Your body can't make neurotransmitters. It could lead to depression, anxiety, insomnia, and all of those things. So I'll check the homocysteine. If it's high, you consider checking that MTHFR gene mutation,

which you need, in order to lower homocysteine, you need the activated form methylfolate. If you have this weird genus enzyme, which about 35% of people don't have the proper enzyme to convert the inactive to the active folate, you get problems, including bad liver, cancer, heart disease, you name it, dementia. So you can check that on a blood test.

And again, it's not in your regular lab, but it is on the function panel. Right. So, so if that you, in your panel is homocysteine in there? Absolutely. Yeah. So what about MTHFR? That's an option. Okay.

So if you're, yeah, if their homocysteineines high, check that MTHFR and then you support them with B vitamins. You can support them with things like taurine, omega-3s again, because omega-3s, we didn't mention it, but omega-3s can reverse or decrease fatty liver disease as well. Yeah. So omega-3s. So we got a cocktail here. We got N-acetylcysteine, we got vitamin E, the right forms of mixed decopherols. We've got milk thistle we've got ubiquinol we've got um alpha lipoic acid uh-huh um that's a good cocktail and of course making sure you're going to be complex and multi-mineral right right right and all that is required to make all the metabolic pathways in the liver work properly right and then let's not forget curcumin yeah curcumin may help

as well and curcumin is good for heart health and for so yeah so curcumin is like a basically found in curry and turmeric right you can take that as a supplement again very important and again we're gonna we're gonna link in the show notes to what what products and things are the the best best in class there because there's a lot of junk out there you don't want to you know now um it seems like a pretty straightforward plan it's diet exercise stop drinking yeah stop taking drugs that damage your liver, and then be on a number of supplements that can help support optimal liver function. But personalized medicine, functional medicine, right?

So you see what their imbalance is, and you give them supplements based on the imbalance. Not just, and first the lifestyle. Actually, you can give a good go at lifestyle mediterranean food plan omega-3s and just see what happens right mind you these people they they've already ruled out other causes of liver disease they've their doctors already told them no yeah you what you have is fatty liver disease it's not something else because other liver diseases can cause turn the liver to fat but once we know that start with that and then refollow those things that are, find out what their abnormalities are and refollow them and make it more personalized. And the beautiful thing about liver is it regenerates. Like,

you know, it's one of the few organs, if you cut your liver off and give up way half your liver, it'll grow back. Right. Right. So if it's like a salamander or like growing an arm, except it's one of the few organs. So if you actually can give a liver, part of your liver to somebody else as a transplant and you're still alive and have a liver, it would grow back, which is pretty cool. So it has a lot of capacity to regenerate. So tell us in terms of this approach, when you have someone come in with fatty liver,

whether it's a more advanced stage or a less advanced stage, what kind of results are you seeing? Can you share some cases of patients who've had this and they've followed this approach and actually reversed? Right. No, there are tons of cases that follow. So it goes anywhere from at least improving their markers, their blood markers, and improving their fat in the liver to people that had fatty liver that no longer have fatty liver. Like it's using this personalized approach, it works. We see it. And the beautiful, I tell you the most frustrating thing for me,

I hated even getting into fatty liver. I hated talking about it because I tell them they have fatty liver and then tell them to lose weight. And then how do I know if it's getting better or not? I have no way of telling. And now I'm so excited that we have ways of telling. New diagnostic tests. And the other scary thing.

So I'll tell you about a case I had too. A lady who had fatty liver disease, was told she had fatty liver disease years ago, right? And now we have this technology. She's coming and seeing us. We do the FibroScan and it shows high fibrosis. And we do a biopsy. She has cirrhosis. Now, probably saved her life because we get her in a study we work on a functional medicine approach

but imagine like this person knew years ago she had fatty liver disease but instead of the only thing she was told is yeah lose weight and and sometimes they do it without even without even thinking that they will. So the problem with functional medicine is we say, okay, you are diagnosed with this condition, and here's this one drug. Take this pill to fix the disease. But with functional medicine, it's multi-causal and multi-modal treatment.

In other words, there may be many factors. So you might have to clean up the gut if people have dysbiosis or bacterial overgrowth. You might have to get rid of environmental toxins if they're not filtering their water, they're eating too much tuna, or they're having exposure to all kinds of chemicals in their environment. You might have to do a lot of things to kind of help reduce the risk. So we do multiple things, diet, exercise, supplements, other factors, reducing toxins, fixing the gut. That's the whole functional medicine approach. What are you seeing in terms of the kind of data on this?

Are there studies that show multimodal treatment approaches? Because it's not how we study things in medicine have you have you done or has anybody else done studies that look at collective interventions to actually see what kind of change we can get in this as far as i know there is no study that does like the bredesen protocol that that follows a multimodal approach all i can tell you is in our clinical practice we have seven providers we we take insurance, we have... Actually the FibroScan company knows us really well.

The company that is doing this research knows us really well because we send so many people to get FibroScans. We just open the floodgates and send them through. But we have probably done thousands of fiber scans because of this in the last couple of years. So we're able to see. And you see the changes. We're able to see the changes.

Yeah. But it's very different. Do people normalize? People normalize all the time. Yeah. So this is the problem. And I think it's like the way medicine works and the way medical research is done is, okay, let's see a federal.

Let's just give you vitamin E and see what happens. Right. Or let's just give you a little exercise and see what happens. Or let's just give you milk thistle and see what happens. Right. It's the wrong way to do it because you have to treat all the things. You can't just treat the one thing and you have to fix all the dysfunctions. So that's really the beauty of functional medicine.

And I think it's stunning to me that we have something that affects a third of the population. And nobody's doing any real research on how to actually fix this. Now, there are drugs that are in development. Maybe we can spend the last few minutes talking about what's on the horizon, what's the future of this, and how do we start to think about it. Because it's a little scary to me. I was at an obesity conference, a pediatric obesity conference. And I met this guy here who was a hepatologist,

a liver specialist in kids. I'm like, what are you doing here? He's like, well, all these kids drinking soda all the time. At 15, they're needing liver transplants. Oh, God. Liver transplants in kids from fatty liver. So tell us what the future looks like. Yeah, so the future looks like these drugs being developed,

one drug per condition that have side effects. And there is a role for them, right? But also the future looks like us unpackaging. And we could take this new drug and unpackage it as functional medicine providers, right? But also the future looks like us unpackaging, and we could take this new drug and unpackage it as functional medicine providers, right? But maybe that'll be a nice end of the show or how you bet your show, end it however you want. But we take all of this information and we unpackage it and we use a functional medicine approach. So there are things called P-par gamma agonists. So there's a drug coming out that is P-par alpha, gamma, and delta. There's anti-inflammatory

drugs coming out. And the one that just got approved, this red medirom, if you look at what this is, res medarom, the thyroid gland, the thyroid gland makes thyroid hormone. And for thyroid hormone to work, it has to bind to what's called the thyroid receptor. There's two types of thyroid receptors, alpha and beta. Alpha will be in some areas of the body, Beta will be in other areas. Alpha is found in the heart. One of the problems with just giving people a bunch of thyroid medicine and why we're very careful with giving thyroid medicine is because it could overexcite the heart.

It's a super high heart rate and... Arrhythmia, stroke, death. That's why. I mean, otherwise, just give people thyroid, let them lose all the weight, right? Because it's a metabolism hormone. So what this does is that this is a beta agonist and a beta is found in the liver, but not found in the heart. So it stimulates the liver. Now it does have its side effects. It's a thyroid pill for your liver, basically. Just for your liver, just for your liver. But then what happens if you give the beta without

the alpha? Is that going to lower the effect? I mean, there's so many questions on what the long-term effects are going to be. And how big of an improvement is there? There was a significant... I need to look at those numbers. I mean, is it... But there was a significant... It was enough to get the FDA approval, but it did show significant...

You don't need much to get FDA approval. No, you're right. You're right. I don't know the number either. My guess is if you compare it head-to-head with an aggressive lifestyle and functional medicine an aggressive lifestyle and functional medicine approach, it would outshine this drug or any future drug by far. No, 100%. So people are looking for the quick fix and the quick pill, but it's not coming. But we as functional medicine providers now unpackaging that what we know is that when we are stressed our body wants to hold on to fat right

because our ancestors when they were stressed they were it was because their life was in danger they either couldn't find food or something was trying to make them food you have to slow down your metabolism right and you can't slow down if you you don't want to turn off the thyroid but what what happens is is that that TSH that signal that comes from the brain still works but instead of making t3 you make reverse t3 and reverse t3 blocks your thyroid and if you look at conventional doctors they don't check reverse t3 right so with the very quick pearl that I would now that that I would add to the the fatty liver disease plan is I would do a full thyroid panel.

I would take TSH, free T4, reverse T3, total T3, and thyroid antibodies. And there is a— Which, by the way, your traditional doctor doesn't test all of it. They just check the TSH. And they don't look at all those thyroid antibodies. They don't look at T4, T3. Some of them look at T4. And they for sure don't look at—

The rock stars. The rock stars look at T4, T3, some of them look at T4, and they for sure don't look at... The rock stars. Rock stars look at T4, but beyond that, forget it. So now what happens, T3 is the more active hormone anyway. The T4 has to become T3. There's debate on whether T4 has an effect or not, right? So that being said, when we're looking at those ratios, we look at the T3 reverse T3 ratio, and we're trying to make sure that that number is greater than six. If it's less than six, we know something is happening and they're not converting. So we work on stress management. There are supplements to give to lower cortisol. We can check cortisol levels. And there's now another herb. There's an herb ashwagandha. Ashwagandha can help convert. Say that again. Yes. Okay. And there's now another herb. There's an herb ashwagandha. Ashwagandha can help

convert. Say that again. Yes. Okay. And there's an herb called ashwagandha. And ashwagandha can actually help convert your T4 to T3. Now there was a case study showing liver disease with, or liver, elevated liver enzymes with ashwagandha. You have to make sure you get a clear source. You have to make sure you're following those liver enzymes, and if you start one supplement and the levels go up, then, but optimizing the thyroid, that, what the new $4,000 a month drug does, right, we can take that information and say, this is another piece to the puzzle, so I need to make sure I do comprehensive thyroid panel on my patients that have fatty liver so that I can start working on that as well.

I mean, Oz, you take that $4,000, you shave it down dramatically and give people free food for six months. It would cure their fatty liver disease. But I'm working on that in Washington. Well, this is amazing. I think, you know, I really think this is an important new awareness.

And we were talking earlier before the podcast about how people are now starting to recognize this and hearing about it. It's more than news. There's articles in newspapers about it. And I think it's a good thing because up to now it's been sort of neglected by doctors because doctors don't like to check things they can't do anything about. Right. If they can't do anything. But now, and I don't think the doing anything about means drugs. I think it means actually figuring out how to deal with the root cause of it, which is primarily lifestyle. But it's also the things you mentioned, like environmental toxins.

You know, the good news is, you know, you do a lot of work to train physicians. And, you know, we certainly do that at the Institute for Functional Medicine. But you have your own training course, and people can go learn learn about MAPLD or whatever you want to call it now. What's it called now? MASH or? Mazeld. Mazeld. And it's mfmpessentials.com. And it's a course for practitioners, but if you're not a practitioner, you want to learn more about it, you can. I think everybody needs to really understand they need to get checked. They need to get tested. This is really common.

It's life-threatening. It progresses if you don't do anything about it. It's invisible. It's symptomless. But the good news is there are clear strategies, particularly through a functional medicine lens, of how I diagnose it and treat it effectively. So I really want to applaud you for bringing this to awareness for you're here. I'm going to give a talk at the Institute for Functional Medicine Conference. And

I, I'm excited to hear that talk. And I think everybody should be very excited to go get these lab tests and go get checked. So just quick reminder, functionhealth.com forward slash Mark. If you want to skip the 200,000 person wait list, you can kind of learn about what's going on in your body and be empowered to sort of be the CEO of your own health and learn from what we have. And we'll put all again, all this in the show notes. Yusef, it's been great to have you on here. Thank you so much for the work you're doing and just making the world a better place. Pleasure is mine. Thank you so much. I don't know how you take care of your seven kids and are part of 15 siblings, but God bless you. Thank you.

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