The Dr. Hyman Show - The Best Foods To Heal The Gut
Episode Date: July 4, 2022This episode is brought to you by Gut Food, Rupa Health, ButcherBox, and InsideTracker.  Our gut, and the tons of bacteria that reside within it, regulates many of our bodily functions, from creatin...g vitamins to controlling our immune system, our brain function, and, of course, our metabolism and weight. The gut is the number-one place to investigate when healing the body of any chronic symptoms or diseases. If your gut isn’t healthy, you’re not healthy!  In this episode of my Masterclass series, I am interviewed by my good friend and podcast host, Dhru Purohit, about why prebiotics are vital in creating a healthy gut. These are the things your good gut bugs love to munch on. In turn, they produce beneficial compounds such as short-chain fatty acids, which have been shown to help prevent things like colon cancer.  Dhru Purohit is a podcast host, serial entrepreneur, and investor in the health and wellness industry. His podcast, The Dhru Purohit Podcast, is a top 50 global health podcast with over 30 million unique downloads. His interviews focus on the inner workings of the brain and the body and feature the brightest minds in wellness, medicine, and mindset.  This episode is brought to you by Gut Food, Rupa Health, ButcherBox, and InsideTracker.  Check out Gut Food at gutfood.com.  Check out a free, live demo with a Q&A or create an account at RupaHealth.com.  Sign up today for ButcherBox and get two ribeye steaks free in your first box by going to butcherbox.com/farmacy.  Right now, InsideTracker is offering my community 20% off at insidetracker.com/drhyman.  In this episode, we discuss (audio version / Apple Subscriber version): Why is gut health so crucial? (6:07 / 1:46) Resistant starch (9:48 / 5:33) How and why to increase short-chain fatty acids (13:56 / 9:42) The many benefits of acacia fiber (16:19 / 11:58) Galactooligosaccharides for gut health (18:22 / 14:00) Probiotics, prebiotics, and polyphenols in my meals (21:44 / 16:00) One prebiotic food that everyone should consider eating (24:39 / 19:00) Questions from my community (27:27 / 21:42)  Podcasts, Products, & Research Mentioned  Disclaimer: This podcast is for educational purposes only. This podcast is not a substitute for professional care by a doctor or other qualified medical professional. You should always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal, or homeopathic supplement, or adopting any treatment for a health problem. The use of Gut Food or any other products or services purchased by you as a result of this podcast does not create a doctor-patient relationship between you and any of the physicians affiliated with this podcast. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.
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Coming up on this episode of The Doctor's Pharmacy.
We have massively messed up our guts.
We have to really understand the gut is central to our health.
How do you hit the reset button on your gut?
In my practice, I always look at the gut first.
When someone's gut is messed up, it can impact their overall health,
their mood, energy levels, skin, digestion, and everything in between.
I always thought I did a pretty good job at taking care of my own gut,
but when I got really sick a few years ago
from mold poisoning, a root canal gone wrong,
an antibiotic, and a few other insults,
I realized that I had a lot of gut healing to do.
I talked to S-Burson Gut Health,
read a ton of new research on the microbiome,
and figured out a way to heal my body
using three critical things,
prebiotics, probiotics, and polyphenols.
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And now let's get back to this week's episode of The Doctor's Pharmacy.
Hey everybody, it's Dr. Mark Hyman. Welcome to The Doctor's Pharmacy and to a new series
on The Doctor's Pharmacy called Masterclass, where we dive deep into popular health topics,
including inflammation, autoimmune disease, brain health, gut health, sleep, and lots more.
And today, my friend, my business partner, our podcast host, Drew Prowitt, and I are going to
be diving deep into part three of our gut health series. Today, we're talking about a critical component of gut healing,
which is prebiotics. Prebiotic foods are so essential if you want a healthy gut.
So what are they? How do you incorporate them into your diet? And how does it all work? That's
what we're talking about today. Kick it off, Drew. All right, Mark. Let's do it.
I think we first start off with a little bit of a recap.
We've been talking about the gut for the last few weeks in this little mini-series that we're doing.
And we introduced the idea of a multivitamin for the gut, which incorporates some of these
key elements we've been discussing.
This is a product that you formulated that you've been involved with for the last two
years and now bringing out to the market.
It's called gut food. And as a part of that, we dove into the three
kind of categories that play a crucial role in gut food. We talked about polyphenols,
we talked about probiotics, and today we're talking about prebiotics, another very central
piece of the puzzle. And all that together just really rounds out this trifecta of critical gut healing ingredients.
So Mark, just remind us big picture in case anybody missed the first two masterclasses,
which the links are below. Please go back and listen to them after you listen to this.
Why do we need to pay attention to the gut and why is it so crucial for all aspects of health,
especially longevity, which you're focused on a lot, right? Yeah. I mean, listen, this is the century of the gut, honestly. The microbiome has taken off as a
field of research in the last 20 years, and we've learned so much about the relationship between
our gut health and the rest of our health. And it turns out that if your gut isn't healthy,
then you're not healthy. If your gut is messed
up inside, we call it dysbiosis. It's a huge risk factor for heart attacks, strokes, cancer,
obesity, weight gain, diabetes, Alzheimer's, autism, autoimmune disease, allergies, asthma,
and of course, all the digestive disorders of irritable bowel and reflux, inflammatory bowel
and bloating. I mean, you name it, the microbiome plays a role.
Even longevity.
In my longevity research, it's astounding to see the changes that happen in our microbiome
as we age.
And the healthiest people as they get older have healthy microbiomes.
The centenarians' poop is much healthier than some young guy's poop who's 60 or 70
who's got all kinds of
health conditions.
So it's really central.
And the question is, why is our gut so messed up and how do we fix it?
And the reason our gut's messed up is our processed diet, is a lack of fiber.
We used to eat 150 grams of fiber per person a day.
Now, as hunter-gatherers, now we eat about eight to 15. And that's why so much
constipation exists. And in my book, I talk about Dennis Burkett, who was a British physician who
has lived in Africa as a medical missionary. And he's noticed this huge difference in the health
between the urban city dwellers in Africa and the rural hunters and gatherers who are basically
genetically the same. And he noticed that the stool weight of the hunter-gatherers was two pounds a day.
And that of the urban city dwellers was four ounces, like a little teeny turd.
So, he didn't know why, he didn't quite understand, but he saw this huge correlation between the
size of your poop correlated with the size
of the amount of fiber you're consuming and long-term health risks.
I mean, elephants have, I think, 50 pounds of poop a day or 50 kilos or something crazy
like that because they're eating so much stuff.
So, we have to learn how to rebuild and reset our guts.
And the reason they're messed up is our processed diet, C-sections,
lack of breastfeeding, overuse of certain drugs like antibiotics, acid blockers, anti-inflammatories,
the glyphosate in our food supply, which is on 70% of all crops, is a microbiome killer.
So there's so many reasons, toxins, pesticides, herbicides. We are just a culture that is gut
busting, a society that is gut busting. And so we need to be proactive
about maintaining and optimizing our gut health, which is really why we created this product,
Gut Food, as a multivitamin for the gut. Nobody's really talked about that. How do we keep our gut
healthy? I mean, yes, there's programs and products and treatments for people with severe gut issues,
but how does the average person just keep their gut healthy with a low friction opportunity to actually add in the things we know are necessary on a daily
basis to keep your gut healthy? Probiotics, polyphenols, and prebiotics, which you're
going to talk about today. Yeah. We're going to dive all into prebiotics. And the thing is,
much bigger than any kind of product that you're affiliated with or any companies that we work
with or anything like that, this is really about education and education on these topics for low-hanging things,
diet first, right?
We always say it, diet first.
That's the first thing that we need to focus on.
So on that note, there's a prebiotic food
that you're a huge fan of,
and it's been shown to help out with weight loss,
improve metabolism and blood sugar,
and that's called resistant starch.
What is resistant starch?
And what are some of the common examples that are available to people out there? Yeah, I that's called resistant starch. What is resistant starch and what are
some of the common examples that are available to people out there?
Yeah. I mean, so resistant starch, it means that rather than being absorbed by the body,
it's not absorbed, right? So, it's resistant to absorption. So, if it can't get absorbed and you
can't use it as calories or fuel, what happens to it? Well, it's eaten by the
bugs in your gut. Now, if it's the right kind of starch called resistant starch, it actually starts
to fertilize the good bugs because they start to eat this starch and they grow and the good guys
grow. And this seems to have broad implications for improving metabolism, for lowering obesity,
lowering insulin resistance, curing diabetes. It's really impressive. And it's in certain types of foods. For example, plantains,
green bananas, lentils, Jerusalem artichokes. There's a whole bunch of these have resistant
starch that can be taken and eaten on a regular basis that will help to actually
create a better gut environment. So it's a really
beautiful way to eat and actually not get the calories, get the taste, and have your gut be
really healthy and happy at the end of it. So Mark, you just listed a bunch of them. What are
a couple of your favorites and how are you incorporating them into your diet on a regular
basis? Well, plantains are great. I love those. You can stir fry them, cook them. You can put
them in smoothies. Lentils are great. You can make lentil soup. Those are really great resistant starches.
And just to interject really quickly, on the plantain side, plantains definitely have less
total sugars compared to bananas and stuff. But being the blood sugar guy, people are always
asking, right? You're like, okay, you're saying this thing is good for being a resistant starch.
And how do I be mindful about incorporating my diet if I'm trying to also be very
healthy? Yeah, but resistant starches also tend to help with insulin resistance and insulin
sensitivity. So they're not as having these big spikes and they're actually being consumed not by
you, but by the bacteria. And they produce something called short chain fatty acids,
which are incredibly important as fuel for the gut cells, as regulators of signals of cancer risk,
and are so important for your
overall health.
And that's what's so beautiful about prebiotics is that they help grow the right bacteria
which are producing in these short chain fatty acids, including butyrate, that are so protective
against a whole host of diseases.
Yeah.
And also, I understand that green bananas are also in that category.
Yeah, green bananas.
Green bananas.
That means that they are like-
Unripe bananas.
Unripe and there's less sugar content that's there. Yeah, but they don't taste that good.
They don't taste that good. But you could kind of
figure out how to make them. You could cook them. And there's like powders
that are out there as well. Are you a fan of those?
Yeah, there's powders and there's
you can take potatoes, like little tiny
potatoes that are
that are like the Peruvian
potatoes that are already lower in starch
and sugar. You can cook them and cool them and then you can eat them that way in like a potato salad and
those are more resistant starches so there's a lot of ways to sort of make resistant starch
but but i think the naturally occurring ones are the best like lentils and plantains and green
bananas sure and following a bunch of tips like uh the glucose goddess who was recently on your
podcast was talking about you know putting clothes on carbs, adding a little bit of fat, right?
Having them with a bunch of fiber.
Fiber, yeah, fiber, man.
Those are things that are going to be helping
and making sure you get the benefits
without the blood sugar impact.
So funny, I just did a talk at a university
called Queens University in Charlotte, South Carolina.
And this woman was interviewing me,
who was like a top chef.
And she was really great.
She was a chef.
And she has to do a tasting contest of desserts. So she's freaking out that
she's going to gain weight because she has to test eat all these desserts for the next month.
And I said, well, all I have to do is take something called PGX, which is polyglycoplex,
basically made from cognac root, which is a very highly viscous fiber that absorbs 50 times its
weight in water. So I said, just take that about 15 minutes before you eat dessert. It won't spike your blood sugar. You'll be fine.
Yeah. PGX is a great product. Shout out to the company. Natural Factors, I think is-
That's right. Natural Factors is a really great product. It's kind of a hack. You take that
before you eat and you do much better. Yes. Although it's tough to drink a big
glass of water with it. You got to make sure you drink at least two glasses of water with it, you got to make sure you drink like at least two glasses of water with it if you're going to take it. Okay. So can you talk a little bit about the compounds that are produced when
our gut bugs eat prebiotics? Why are these so critical for overall health?
Well, these compounds I mentioned are short chain fatty acids and that's a big mouthful. But these
are the products that are produced by bacteria when they're digesting the right fibers and including prebiotic fibers.
And, you know, yes, we talked about resistantokes, asparagus, onions, cognac root,
which is what I was talking about, the PGX, cocoa actually, flax seeds, jicama, seaweed,
and polyphenol-rich foods. These are all prebiotic foods. So we need to include these in our diet.
So when I go to the grocery store, I'm going to get asparagus and artichokes and onions because
I know these are prebiotic foods. They're going to help my microbiome. I think about it. Or I'm
going to buy jicama and put it in my salad because it's a prebiotic food and I
want to actually increase the food for my good bugs.
So I'm shopping, thinking about this all the time.
And the reason they're important is they produce these compounds, short-chain fatty acids.
Butyrate is one of the most important ones.
And we know that butyrate is not just for providing fuel for the colonic cells to keep
them intact and everything working,
but it's actually also a cancer regulator, an inflammation regulator. It regulates the risk
of heart disease and cancer and diabetes. So it has so many benefits. It's one of the most
important molecules in the body, butyrate. And we don't have enough of this. And I test my patients
stool all the time. And I see so many people are just so low in butyrate. And it really is
necessary because it's necessary to keep your metabolism up, to reduce inflammation,
to prevent cancer, and to help heal a leaky gut and prevent a leaky gut.
So when you, for example, have low butyrate levels, you can't maintain the integrity of
your gut lining.
That causes a leaky gut.
You get food allergies, food sensitivities.
You get leakage of bacteria.
You get systemic inflammation.
That leads to more weight gain, more inflammation, more heart disease, more cancer, more dementia, more depression,
I mean, it's going to go on and on. So basically, when you have prebiotic foods, it helps the gut
bugs flourish and then they can replicate, they produce their vitamins like vitamin K and biotin,
they regulate your hormones and they basically remove toxins. But when you don't have these
good bugs, you're kind of screwed. Well, one of the prebiotics that's in your formula that you put together, gut food,
is acacia fiber. Talk to us a little bit about that and why it was one of the things that you
were using when your gut was messed up and you were dealing with a lot of leaky gut,
which had a whole host of challenges.
Yeah, for sure. So acacia fiber is a really wonderful prebiotic fiber. It's well tolerated often more than other fibers because they can be part of the system.
It makes you feel full.
It helps control blood sugar and cholesterol.
It's an antioxidant and it helps really help correct a leaky gut.
And what's really quite amazing about acacia fiber is it's actually been studied to lower
a whole set of cytokines basically through lowering something called NF-kappa-B.
NF-kappa-B is what we call a transcription factor.
It's a compound that the body makes to tell your genes that there's a problem and to make more inflammatory molecules called cytokines.
And then you get all these cytokines produced like TNF-alpha andukin six and interleukin eight, which are very inflammatory. And you get, um,
kind of, um, you know, all these problems when you have inflammation. So when you, when you
actually have a case of fiber, it lowers the NF-kappa B, it lowers IL-6, it lowers the TNF
alpha, these dangerous cytokines, and it actually increases the anti-inflammatory cytokines like interleukin-10.
So you've got a break and you've got to accelerate it on your immune system, right?
So you don't want the accelerator going all the time.
You don't want the break going all the time.
So we have just so much in our culture, in our life, in our environment, our diet, our
toxic load that drives inflammation.
And so if you're not getting compounds that help to lower that,
you're actually accelerating aging and obesity and all the chronic illnesses. So it's super important to make sure your cytokines are balanced. And that's really key. And that means
making sure you have enough of the prebiotic foods that produce the short chain fats
and take care of it. And that's the acacia fiber is another one of the essential fibers. It's so key.
I love it. There's another prebiotic that's also included in the formula that I'd love to have you
talk about. Galactooligosaccharides. It's a mouthful.
GOS.
GOS.
From GOS.
As it's often referred to. What are the benefits and some of the research show about GOS?
Well, you know, it's quite amazing i've taken this product uh quite a while
and and it's it's powerful product because it it is so good at feeding the good guys
and in seven in in 14 days and bloating is a huge problem for people like the food baby thing you
know it's a real thing i promise you i mean my patients have me pictures of it all. I look at my food baby. I'm like, but 71% reduction in bloating at 14 days, a 92% reduction in pain,
a 71% reduction in flatulence or gas. That's a big deal. And these are really debilitating
symptoms for people. And what's also interesting is that it doesn't just
affect the bloating, gas, and digestive symptoms, but it has indirectly effects on the immune system.
So you see almost a 60% increase in phagocytosis, which means your macrophages, which are little
Pac-Man that go around and clean up all the problems and viruses, infections, are increased
in function. And natural killer cells, which are really critical for fighting infections and viruses and cancer, there was 106% increase in natural killer cell function
in 10 weeks. That's impressive. And so that's what helps you fight viruses and cancer.
And there was also a higher level of interleukin-10, which is one of the
anti-inflammatory cytokines. It's all from taking a prebiotic. This is how powerful they are.
Hey everyone, it's Dr. Mark. If I've learned one thing during my two decades in functional medicine,
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Okay, Mark, switching to the next part of this discussion. So typically when people think of
the gut, they think probiotics. But what we're seeing is that prebiotics are just as important,
especially for creating these beneficial compounds that improve
digestion and help prevent even chronic diseases that are out there, the top ones that we all know
about. Ideally, this means eating a high fiber diet. So let's break down a typical plate of food
for you. How much fiber and prebiotics are in that plate of food and how much fermented food and how
much protein and how much fat? Just describe your typical meal. Yeah, sure. I mean, I think it's important to understand that probiotics are like the seeds
you put in the garden. Prebiotics are like the compost you put on the ground to make the seeds
grow. So it's really important to think of them together. And the polyphenols are like super fuel
on all that stuff. And it's a trifecta of a powerful set of compounds that really have never been put together in a product before.
And that's really why we created Gut Food.
And when you look at my particular day, I tend to eat a lot of fiber-rich foods.
And I love those foods because I just like them.
But it includes a lot of veggies.
Tons of raw veggies and salads, cooked veggies.
Cooked onions.
We learned last time you can't have raw onions.
Cooked onions.
For example, the other night, as a meal, I had duck breast. I had shiitake mushrooms, which are also very high in certain
compounds like polysaccharides that are helpful for immune function.
We had artichokes. I had steamed artichokes, which have, again, prebiotic fibers and also
folate and detoxification compounds. I had, I think, a Japanese sweet
potato, which again is full of fiber and also phytochemicals and polyphenols. And also I had
asparagus. I had stir-fried asparagus with ginger. So I'm providing all the spices and the asparagus,
which also is a prebiotic food, into my diet as just a natural part of cooking and what I like to
eat. So, I've sort of learned to include some core foods in my diet on a regular basis that I know
are both probiotic foods and prebiotic foods and also fermented foods. So, I have miso, I have
kimchi, I have sauerkraut. I like pickles, being a good Jew. So, basically, I eat a lot of these
foods and then I'll have – I'll make sure I eat – those are probiotic foods.
And I'll eat the prebiotic foods, like I mentioned.
And the polyphenols.
So I tend to eat a lot of colorful fruits and vegetables.
And then as fats go, I tend to stay away from refined oils.
Avocados are great.
Nuts and seeds are great.
Extra virgin olive oil is great.
So I tend to stick to those fats.
And protein is just your palm size
serving of protein. So if you're three years old or you're 50 years old, whatever your size of your
palm is, that's about the protein needs you have per meal. And that can be plant proteins or animal
proteins. But the plant proteins, you typically need to eat a lot more to get the same grams of
protein. If there was one prebiotic food, the people that are listening today,
somebody's like, you know, I'm not eating any of the prebiotic foods. There's one that could be a
great starting place, maybe a little easier on the palate, but still beneficial to them.
What's that one prebiotic food that if they're not including today, they should think about
incorporating? Well, it's kind of a fun one and it sounds counterintuitive, but it's noodles.
And not just any noodles,
but a special kind of noodles called shirataki noodles.
And these noodles are Japanese noodles that are made from cognac root,
this fiber I talked about that was in PGX.
It's a prebiotic food,
but also has tremendous power
to slowly absorb glucose and fatty acids
and other things that actually drive weight gain and obesity. but also has tremendous power to slowly absorb glucose and fatty acids
and other things that actually drive weight gain and obesity.
And you can enjoy them because they have no calories
and they have no carbohydrates.
It's just fiber.
So you can make pasta with them.
You can put them in soup.
They're delicious.
And you can buy them now pretty much everywhere.
You can buy them online. They're called like miracle noodles. Miracle now pretty much everywhere. You can buy them online.
They're called-
They're called like miracle noodles.
Miracle noodles. Yeah. The shirataki noodles. They have weird ones that are made from soy,
but get the ones that are made from cognac root. That's K-O-N-J-A-C, not cognac like the drink.
And that's kind of a fun one.
We make stir fries at our place all the time. By the way, we have no affiliation with this
company. It's just something nice that people like to incorporate.
Yeah, exactly.
It's a good way to get you off a lot of that refined carbohydrates if you're eating pasta on a regular basis.
Nothing wrong with enjoying some pasta here and there.
We had some pasta last night as a special treat.
We went to a friend's restaurant.
It was heirloom grains.
Yeah, it was heirloom grains, and they're bringing in from Europe and other stuff.
But that's not how we eat on a typical basis.
So Miracle Noodles are a nice way to mix it up and get some of that texture that people enjoy from noodles and pasta, but not have it be so detrimental to your metabolic health.
Absolutely. And then I think if you really want to, you know, get into it, you can have more
artichokes and plantains and- How easy is it to cook artichokes? They can look intimidating.
Oh my God. Artichoke is the easiest thing in the world. You just take it, you can,
you basically steam it for an hour and you have to make sure enough water's in the pan or boil it.
And then take it out and I just dip it in olive oil and vinegar.
That's it.
You don't do the oven.
You do steam it.
I just steam it.
It's usually about an hour depending on the size of the artichoke.
Like a little pot and a bamboo steamer do you use?
No, I have like a pasta pot, which I don't really use for pasta anymore.
But I fill the bottom up with water and it's got a metal strainer in it.
I put them in there.
You can also boil them too. You can just boil metal strainer in it and I put them in there. Yeah.
You can also boil them too.
You can just boil them.
That's fine.
I like to steam them,
but yeah.
And then when they're soft
and the leaves pull off easily,
you take it out after about an hour
and then you just dip the leaves in artichoke.
It takes a while to eat.
You have to dip the leaves
in the olive oil and vinegar
and you scrape off the yummy parts
of your teeth.
And they taste great.
And if you're not used to eating them
on a regular basis,
maybe start off small initially
and then you can slowly work your way out.
And you also don't want to eat the hairy parts in the middle. You have to get to the heart of
the artichoke and you have to take off the hairy bits in the middle, but it's fun. It's an
adventure. It's an adventure for sure. So Mark, as part of this mini series, we haven't gotten
to many community questions, but we'll toss in some community questions here. And these are from
your audience, your Dr. Harmon Plus audience, your Instagram audience, your podcast audience.
So let's jump right in. So first question, can you take pre and probiotics at the same time?
Absolutely. You want to, because you want to fertilize the bacteria. So you want to fertilize
the bacteria in your gut that are already there, but also if you want to help grow a little bit
more of the actual ones you're giving. So it's certainly fine to take them at the same time.
The one caveat is if you're taking prebiotics and probiotics and you have bacterial overgrowth or fungal overgrowth in your gut, it can create a war and you can often
feel a lot worse. And what's an example of that happening or taking place?
Well, I mean, if you start taking probiotics and all of a sudden you feel like you had somebody
come with a tire pump and pump up your intestines and you're bloated and distended and it's painful,
that's a clue that maybe there's
something rotten in Denmark and you need to go figure out what's going on in your gut
that needs weeding. Is it a bacterial overgrowth, fungal overgrowth, is it a parasite?
Then you can kind of make a more coherent stand on what actually is working or not.
And often one way different companies will do this is you're taking a prebiotic it's
something new to you or you're taking a probiotic you start small and you build your dose up so
your body can get used to it and i think that's even in your recommendations around gut food as
you start tight for sure start slow and build up slow yeah exactly and i think there's instructions
on how to do that um what are your thoughts about jicama and is it one of the best probiotics
that are out there? Prebiotics. Sorry.
Jicama is a great prebiotic. So if you know what jicama is, it's like a, I think a Mexican
kind of-
South American.
South American-y kind of vegetable that is like a big white root or something. And you basically
peel it and you cut it into thin little matchstick slices and you can throw it in your salad. I love
it. I love putting it in my salad.
It's crunchy.
It's kind of got a nice taste to it.
And it's a great prebiotic.
So it's a go-to for sparking up your salad
with a prebiotic fiber.
And it's been really interesting to see
a lot of companies start to incorporate jicama
in their products.
Your friend Mona, my friend Mona,
they have their product jicama spelled with an X.
We linked to the show notes.
It's a nice beverage mixer that people can use for just by itself for solo.
And then our buddy Junaid.
And we invest in his company's farmer's juice.
One of the ways green juices spike people's blood sugar so much because they have so much fruit juice inside of them.
And he used Hikama to improve the taste,
but not spike people's blood sugar. And I'm so excited about all those companies. Those are two
of them. And then there's plenty of others that are out there that are using jicama juice in
their products. So if your diet is in check and pretty pristine, do you still need to supplement
with prebiotics and probiotics? I mean, not necessarily. I mean, if you're eating a hundred
grams of fiber a day and good luck, let me see that. And you're eating the right prebiotics and probiotics? I mean, not necessarily. I mean, if you're eating 100 grams of fiber a day,
and good luck, let me see that,
and you're eating the right prebiotic foods,
and you're really doing the right things by your gut
in terms of your overall diet,
I think it's not necessarily to take prebiotics.
But for most of us out there,
our guts are pretty messed up,
and we need a daily dose of something to help.
Now, if we're not going to be eating,
it's like traveling right now. So I can't always control what I'm getting. I try my best. Now, if we're not going to be eating at 3 a.m., I'm traveling right now.
So I can't always control what I'm getting.
I try my best.
I mean, we had seaweed salad for lunch
because I know that's got prebiotic fibers in it.
That helps me.
But I do like to have the insurance
of having something on a daily basis,
knowing that there's so many things that disrupt our gut,
and it's just a good insurance policy
to get a multivitamin from my gut every day.
Mark, I'd love to get your thoughts on this.
You know, that study around the 150 grams, 100 grams of fiber, there's a gentleman named
Justin Sonnenberg.
I believe he's from Stanford University and he was one of the ones that was looking at
one of the tribes in Africa and looking at their diet, the hunter-gatherer tribes that
are out there.
Hadza.
Hadza, exactly. And in that paper, a little bit of the controversy that's been there online
is that some people in more of like what you, I guess what you call like the carnivore community,
they talk about how a lot of these hunter-gatherer tribes, like fiber was more of a fallback food.
Now, Justin, recently in an interview that he did with Andrew Huberman,
who's also been on your podcast and we'll link to in the show notes, he was saying that,
yes, it's a fallback food. They would prefer honey all day. They would prefer to eat honey
all day, but they just can't get a honey all day. They would prefer meat all day,
but hunting is a little bit tough and not always are animals there. So whether it was done by
design or by default, he's saying they're still having this amount of fiber in their diet. So they have the same food addictions that we have.
So if you could give them processed food all day, they would choose processed food all day. It's
not like they have some enlightened idea around food. And just any thoughts on that big picture,
like any extrapolation you want to add in? Because some people would say, well, when they can get access to meat and honey, they would choose and they would prefer that. So
since we have meat and honey all around us, why do we need to be having things like fiber as a
regular part of our diet? It's just one of the arguments that's out there.
I mean, listen, if you're a carnivore, your gut microbiome changes very fast.
If you're an omnivore, it's different.
If you're a vegan, it's different.
So what is the right microbiome?
That's really the question is how do you get a healthier microbiome?
And I think, you know, we still haven't figured that out.
You know, we know we can measure diversity, which is important, the complexity of the ecosystem.
We can measure markers like short-chain fatty acids, inflammatory markers.
We can look at what bugs are there, what are not there, what's growing, if there's parasites.
All that is helpful. What I find challenging about some of these microbiome tests is they
only look at the microbes. They don't look at the function of the gut. And as a functional
medicine doctor, that's what I care about, is what are these bacteria doing? For example, some kids I'll see who have autism, very, very low short-chain fatty acids of, for example, butyrate, which is anti-inflammatory, and very high levels of something called propionic acid, which is very inflammatory.
And propionic acid has been shown in animal studies to increase autism and autism
behavior. And if you look at breastfed kids versus bottle-fed kids, they have different
short-chain fatty acids. The breastfed kids have high butyrate because their bacteria are being
fed by the breast milk with the oligosaccharides that are in the breast milk. Basically, the oligosaccharides are prebiotic, right?
This is a prebiotic made by the body for the bacteria for babies in breast milk.
That's what it is.
And if you take formula, there's no prebiotic oligosaccharides.
And so instead of getting butyrate, these kids get high propionic acid.
And that's why we see you know breastfeeding is so important
correlated with better health outcomes and where maybe bottle feeding is leading to increases in
propionic acid which can have adverse consequences for cognitive function for autism and learning
difficulties add and lots more so i think it's important to realize that that our diet really
matters and that the you know prebiotics that are in our food really are key and
so historically if you know if we were hunter-gatherers you know we didn't have a choice
we had to eat whatever we could we got root a berry you know some tree bark or whatever like
and and that's just what we had to do and and that was more of a natural environment for them it was
yes i mean if all all we had was sugar that's all we'd want to eat, we'd be really happy, but we'd get very sick. But they had a wide variety of foods and a far
more complex diet than we do. The whole variety of roots and berries and plant foods and lots of
different kinds of animals. And also they'll eat the bone marrow, they'll eat all sorts of stuff.
So really, really important to think about how do we get the right balance of things for us in a way that isn't going to be too onerous, but that it's going to be designed to fertilize the right bugs and not grow the wrong bugs.
So another question we have from the community, is a prebiotic good for people who have IBS?
What are some of the considerations that people who have IBS have to think about?
Yeah, so generally when I think about someone with a gut issue is the
weeding, seeding, and feeding program. And I think the IBS group can be constipation, can be diarrhea,
but typically there's a component of bacterial overgrowth or fungal overgrowth. So I really am
very careful about when I'm working with these patients, not overdo stuff too fast with the
pre and probiotics. I usually give them a week or two of weeding,
clearing out the bad bugs with herbs, some of those medications, antifungals. And then we see
the body can be able to tolerate these things. There's not a war going on.
All right. Next question from the community. What's the difference in digestive enzymes and
how are digestive enzymes different than pro and prebiotics?
Well, Drew, in order to have a healthy functioning gut, you need a lot of things going on.
You need to be able to digest your food.
You need the right stomach acid.
You need digestive enzymes from your pancreas.
You need salivary enzymes from your mouth.
You need the right fibers and prebiotics to actually help grow the right bacteria.
You need probiotics.
You need postbiotics.
You need all the things you need to actually keep a gut healthy. And so when we're thinking
about repairing and fixing the gut, we need to think about all those things. And I see people
with low pancreatic function, low hydrochloric acid. And so sometimes giving them supplements
with pancreatic enzymes or more plant-based digestive enzymes along with hydrochloric
acid can actually be very helpful.
So it's really depending on the person.
But if people have a lot of SIBO and bacterial overgrowth and digestive upset and undigested food in their stool,
or on their lab test we see low pancreatic elastase,
we can actually help to treat them in an effective way by providing those enzymes for people.
So it's not an either-or.
It's a select group that might need them.
But when you need them, it can be really helpful. And then when you get your gut healthy, you don't need them so much
anymore. Now, sometimes when people are going out to restaurants or they're eating foods like
gluten and dairy, which people partake in every so often, it's a part of metabolic flexibility.
Some of my friends might take digestive enzymes with them to like the restaurant or whatever.
Do you ever do that? Yeah, there's actually gluten digest enzymes. There's lactase enzymes.
There's things that help with that dairy and so forth.
So you can use them to sort of mitigate problems
that you might have if you go out and cheat a little bit,
but it depends on who you are.
If you're a celiac, you don't want to cheat at all, right?
If you're having severe dairy reactions,
you don't want to cheat at all.
But for some of us, you know,
who just may have a little upset tummy or whatever,
I mean, I think it's fine.
I think the goal is ultimately to eat in a way that actually is going to rebuild your
gut so you're more resilient. That's the whole game here in functional medicine. It's not
restriction, but freedom. And metabolic degrees are freedom by optimizing your body's systems.
And once you do that, like I said before, I couldn't eat anything for years without being
sick, without causing rashes all over my
body, my eyes getting red, my tongue getting sores, my stomach bloating, having severe brain
fog, fatigue. I mean, it was so immediate. And I knew exactly what was going on. At the time,
this was almost 30 years ago, I didn't know all that I know now. The microbiome wasn't even a word.
We knew how to work with the gut, but it was really tough and it was hard to reset the system. And for me, it was challenging because
I had mercury poisoning. And if you have something like that, you can do everything you want. You can
take all the prebiotics, polyphenols, everything you want. Unless you get rid of that, you're not
going to get better. So Mark, I think this is a perfect opportunity to do a little bit of a recap.
We've been doing this multi-part series and we've just covered polyphenols to start
and we covered probiotics
and then we covered prebiotics
all under this greater umbrella
of we live in a world
that has never been more destructive to our gut.
So we want to be more mindful
to take care of our gut
because health and disease starts in the gut.
So give us a little bit of recap
of some of the top points
that we learned through this multi-part series and we'll have more to come soon, but at least so far, where are
we at? Yeah, I mean, the first high level is we have to understand as a culture, we have massively
messed up our guts by our industrial process diet, our lack of fiber, our lack of phytochemicals and
polyphenols, by the increasing C-section rates, lack of breastfeeding, the use
of antibiotics and gut-busting drugs like Advil and aspirin. So it creates a perfect storm for
a disaster of a gut environment that promotes all sorts of downstream problems from not just
digestive issues, which are the number one reason people visit the doctor, but all sorts of chronic
diseases from heart disease to obesity to cancer to diabetes to dementia to autoimmune diseases to allergies to asthma to autism to ADD. I mean, that could go
on and on. So we have to really understand that gut is central to our health, to every aspect of
our health. And so we really have come up with a framework for helping people to reboot their gut.
How do you hit the reset button on your gut? Well, it involves diet. So upgrading
your diet and the quality of the food you're eating, increasing the fiber content, polyphenol
content, phytochemicals, super important. Second, we need to supplement with the right things like
a multivitamin for our gut with the right prebiotics, the right probiotics, and the right
polyphenols to help. So for example, in our product gut food, we have
lactospore probiotic, which is a spore-based probiotic, very well-researched. We have
galactooligosaccharides, which are incredible prebiotic food. Acacia fiber is a prebiotic.
We have something called mucosae, which is prickly pear and also olive leaf extract, along with quercetin, which are incredible polyphenols for helping
boost the good bacteria in the gut.
For example, acromantium mucinophilia is highly responsive to these.
It's exactly what it sounds like.
Mucinophilia means it's mucin-loving, so it creates a mucus layer in the gut to prevent
a leaky gut.
So we have all these ingredients that are designed scientifically to optimize the gut environment, to be like a multivitamin for the gut
and to help people really create a baseline that they can rely on. It's like, why do you need a
multivitamin? Well, because we're not eating 800 different food crops anymore and a lot of our
food's depleted and we've had all these problems. So in a perfect world, we should not need all
these things, right? And I always say, oh, you don't need a vitamin, but only under certain conditions,
right? You only hunt and gather your own wild food. You only drink pure, clean water, breathe
pure, clean air, have no environmental exposures, have no chronic stress, sleep eight to nine hours
a night and exercise all the time. Now, if that's you, no, you don't need a multivitamin,
but everybody else, yes. So the same thing with a multivitamin. But everybody else, yes. So the
same thing with a multivitamin. In a perfect world, we wouldn't need this. Maybe if you're
a Hadza living in the jungle and you're eating in Africa all the wild stuff and you're doing
your thing, no, they probably don't need all this stuff. But for the rest of us in modern society,
absolutely. I love it, Mark. Thank you for taking us through all that and more.
Let's go ahead and conclude today's episode on the topic of prebiotics. Well, thanks so much, Drew, for doing this
masterclass with me and doing it on the gut, which is my favorite topic. As I said, they like to call
me Dr. See Every Poop. And if you want to learn what I've learned and you want to take advantage
of what we've been doing for 30 years in functional medicine, have a look at our new multivitamin for the gut. It's called Gut Food. Just go to
gutfood.com to learn more. Sign up for the wait list when it's coming out. Share your stories
with us about what's worked for you for your gut and health and how you optimize your gut function.
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I hope you enjoyed this episode of The Doctor's Pharmacy.
Make sure to check out Gut Food and learn more at gutfood.com.
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and live younger longer. Hi, everyone. I hope you enjoyed this week's episode. Just a reminder that
this podcast is for educational purposes only. This podcast is not a substitute for professional
care by a doctor or other qualified medical professional. This podcast is provided on the
understanding that it does not constitute medical or other professional advice or services.
If you're looking for help in your journey, seek out a qualified medical practitioner.
If you're looking for a functional medicine practitioner, you can visit ifm.org and search
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It's important that you have someone in your corner who's trained, who's a licensed healthcare
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