The Dr. Hyman Show - The Perfect Gut Healing Protocol: What to Eat, Avoid, and Do Every Day

Episode Date: June 22, 2026

Bloating, brain fog, fatigue, skin issues, food sensitivities, autoimmune symptoms—most people treat these as separate problems. But often, they can all trace back to the same place: the gut. And the surprising part is that you don't need digestive symptoms to have gut dysfunction. Because your gut isn't just responsible for digestion—it's deeply connected to your immune system, hormones, metabolism, brain health, and inflammation throughout the body. In today's episode, I dive into: Why gut dysfunction can show up as fatigue, brain fog, skin issues, hormone imbalances, anxiety, and autoimmune symptoms—not just digestive problems The biggest modern-day gut disruptors The Functional Medicine 5R Framework for healing the gut The simple daily habits that help build a healthier microbiome, reduce inflammation, strengthen digestion, and support long-term resilience Healing your gut isn't about perfection, restrictive diets, or endless supplements. It's about creating the conditions your body needs to repair itself. When you support your gut, you're often supporting your immune system, your brain, your hormones, your energy, and your overall health at the same time. Resources Mentioned: Learn more about the 10-Day Detox: https://bit.ly/3PIUoxf Track your metabolic and cardiovascular health biomarkers: functionhealth.com/mark for 160+ lab tests at just $365/year. Use code MARK2026 for $50 off. Have a question you'd love answered on Office Hours? Submit it here (0:11) Introduction and overview of gut health (2:10) Understanding, healing, and factors disrupting gut health (7:45) Modern lifestyle's impact and the five r's of gut healing (17:06) Dietary diversity, mindful eating, sleep, and stress reduction (20:53) Supplements and Q&A on probiotics, diet, and leaky gut (23:06) Empowering listeners through functional medicine and community engagement (24:23) Dr. Hyman's platforms, disclaimer, and gratitude to sponsors

What if brain fog, anxiety, and mood swings aren't simply all in your head? What if the health of your mind actually starts deeper in your body, in your gut, in your hormones, metabolism, and your immune system? Well, let me tell you, the connection is real, and it affects how you think and you feel every single day. And that's why I created Brain Shaping Academy, a six-week program that shows you how healing your body can help you heal your mind. Brain Shaping Academy relies on the same targeted nutrition and lifestyle strategies that I've used

for 30 years to help my patients improve their mental, emotional, and cognitive health. So if you want to feel calmer, clear, and more in control, and stay sharp and protect your brain as you age, check out Brain Shaping Academy at Dr.heimann.com, 4.com slash brainshaping. That's Dr.heimmon.com or slash brain shaping. Welcome to office hours. This is our dedicated one-on-one space to go deeper, get clear, and explore what truly moves the needle for your health. I'm Dr. Mark Hyman, and each week we're going to pull back the curtain and share the insights,

the research, the lessons that don't always make it into our conversations with guests. Because at the end of the day, you are the CEO of your own health. And for many of you, your family's health too. And you might not feel it all the time, but you have far more power in agency than you realize. I'm glad you're here. This episode is brought to you by Function Health, empowering you to live 100 healthy years with over 160 lab tests for just $365 a year and use the code mark 2026 to get $50 off your membership. bloating, fatigue, brain fog, skin issues, food sensitivities, anxiety, autoimmune disease.

Well, most people don't realize these problems all trace back to the same place. The gut. And when I say gut health, I'm not just talking about digestion. In functional medicine, we often see the gut as one of the central control systems for overall health because it influences nearly every major system in the body. You gut affects your immune system, inflammation, hormones, metabolism, nutrient absorption, even brain health and mood. In fact, about 70% of your immune system was in and around the gut. And the trillions of microbes living inside your digestive system,

what we call the gut microbiome, well, they play a major role in regulating inflammation, metabolism, cravings, mood, and so much more. And here's what many people miss. You don't need to have obvious digestive symptoms to have gut dysfunction. Some people have bloating or reflux, but for others, it may show up as fatigue or skin problems or joint pain or brain fog or hormone abouts or autoimmune symptoms or just feeling inflamed all the time without understanding why. That's because when the gut becomes unhealthy, the effects can ripple throughout the entire body. Now the good news is this. The gut is incredibly dynamic and capable of healing when we create the right condition.

So today we're talking about how to actually begin healing your gut. what damages it, what restores it, and the foundational steps that make the biggest difference. And more importantly, we're going to keep this practical, we're going to keep it realistic. It's not about buying dozens of supplements or following some extreme protocols. It's about understanding the basics that truly move the needle when it comes to the gut and your gut health and your overall health. One of the biggest shifts happening in medicine right now is the growing understanding that the gut isn't just about digestion. The gut is deeply connected to almost every aspect of it. health. In functional medicine, we often start with the gut because when the gut is unhealthy,

it can get ripple effects throughout the entire body. There's a reason for that. About 70% of the immune system is in and around the gut. So every day, your digestive system is acting as major communication center between the outside world and your immune system. Your gut is constantly deciding what gets absorbed, what gets blocked, what's safe, what might be a threat. At the same time, the gut is in constant communication with the brain through what we call the gut-brain axis. This means your digestive system and your nervous system are constantly influencing each other. So when people experience stress-related digestive issues, anxiety alongside their gut symptoms, brain fog, mood changes, cravings, these things are often connected more than people realize.

And then there's the microbiome, the trillions of bacteria, fungi microbes that live primarily in your intestines. These microbes are not passive. They influence inflammation, mood, metabolism, craving, skin health, hormone, balance, immune function, even how we process nutrients and toxins. You're not just feeding yourself, you're feeding trillions of microbes that influence your health every day. And the quality of that internal ecosystem matters enormously. A healthy gut is really a balanced, resilient ecosystem. You want healthy microbial diversity, strong digestion, a healthy gut lining, balanced immune signaling, and effective absorption of nutrients. But when that ecosystem becomes disrupted, well, through processed food,

for antibiotics, infections, lack of sleep, environmental toxins, inflammation, well, the consequence of extent far beyond the digestive tract. We can begin to see chronic inflammation, increased intestinal permeability, sometimes we call leaky gut, immune dysfunction, nutrient deficiencies, food sensitivities, fatigue, skin issues, hormone imbalance, chronic symptoms that don't always seem obviously connected to digestion. Even mental health issues are tied to the gut. And this is why so many people can struggle for years without realizing the gut may be playing the central role because the symptoms don't always look digestive. Sometimes the gut's the hidden driver underneath seemingly

unrelated help problems. And ultimately, this is the key idea. When the gut is unhealthy, the whole body becomes inflamed. And that's why restoring gut health can often have such wide-ranging effects on energy, mood, immunity, skin, metabolism, just your role well-being. Now, one of the biggest misconceptions about gut health is that gut dysfunction always shows up as digestive symptoms. But that's not necessarily true. Yeah, some people experience obvious digestive issues, but for many people, the signs are much more subtle.

They show up in completely different parts of the body. That's because the gut influences so many systems of months. Now, on the digestive side, symptoms can include bloating, constipation, diarrhea, reflux, heartburn, excessive gas, stomach discomfort, food sensitivities. These symptoms are incredibly common, but common does not mean normal. A lot of people have normalized feeling bloated after every meal, or relying on antacids daily, or constantly reacting to foods. But those symptoms are often signals from the body that something deeper is out of balance. And then there are the non-digestive symptoms, which people are often surprised to learn can be connected with the gut. Things like fatigue,

brain fog, anxiety, depression, eczema, acne, joint pain, in immune flares, frequent illnesses, sugar craving, low energy after meals, is going to inflamed all the time, and the whole much more. Now, these symptoms may not immediately seem gut related, but when the lining of the gut in the microbiome or the immune system become disrupted, the effects spread through the whole body. For example, inflammation in the gut can influence inflammation in the brain, in the joints, in the skin, in the immune system.

Because the gut and the brain are so interconnected, people often notice that when their guts off, their mood, their focus, their stress resilience are also affected. One thing I see all the time is that people normalize symptoms that are actually important feedback from the body. They see things like, well, I thought it was normal to feel exhausted after eating, or I always had stomach issues, or I just assume that everybody feels bloated all the time. But your body is constantly communicating with you.

Symptoms are not random. They're information. And while symptoms don't automatically tell us exactly what the problem is, they can point toward the areas that need healing and attention. Your gut may be asking for support, and the good news is that even small changes can begin shifting the gut in a healthier direction pretty quickly. And one of the realities of modern life

is that the world we live in is incredibly hard on the gut. Our ancestors didn't deal with ultra-processed food, with chronic stress, with constant chemical exposure, with sleep disruption, with repeated antibiotics all the time. But today, many people are living in a constant state up low-grade inflammation and nervous system overload. And the gut is often one of the first places that shows this impact. One of the biggest drivers, well, it's ultra-processed food, no surprise.

Diet's high in sugar, refined oils, artificial additives, emulsifiers, artificial sweeteners, low-fiber foods, well, they can disrupt the microbiome, and they promote lots of inflammation. Remember, your microbiome and the gut microbes depend on real food and fiber. in order to thrive. When we consistently feed them, processed food instead, well, we ship the balance of the ecosystem in the wrong direction. And then there's stress. Well, there's such an important piece of the puzzle that people underestimate. Because when the body's in chronic fight or flight, the microbiome becomes altered,

inflammation increases, you simply cannot digest, absorb, and repair optimally when your nervous system constantly feels under threat. Antibiotics and medications also have a big impact on your gut. Now, antibiotics can actually be life-saving, they save my life, and they're needed, but when they are used a lot, they disrupt the microbiome, sometimes in a big way. And it's not just antibiotics. Frequent use of nsades or anti-inflammatory drugs like ibuprofen, acid blockers, which are so common, certain medications can also affect the gut lining, the digestion, and the whole microbiome balance over time. Sleep, well, is another huge factor. We know that the microbiome follows certain circadian rhythms,

just like the rest of the body. So when sleep becomes a strong, we're not in the body. So when sleep becomes disrupted, whether from stress or screens or irregular schedules or lack of recovery, it can negatively affect the gut ecosystem as well. Now, alcohol, and environmental toxins can also increase inflammation, and they can place additional stress on the gut and liver. And then there's chronic infections, microbial imbalances, sometimes called dysbiosis. This can include yeast overgrowth, parasites, small intestinal bacterial overgrowth, or other disruptions of the microbiome. Now, for some people, they can contribute to bloating, often call the food baby, fatigue, mood changes, food sensitivities, skin issues, chronic inflammation. But the important thing to understand is this.

It's not actually one thing. Most gut dysfunction develops from cumulative stress on the system over time. It's the processed food plus the stress, plus the porcelain, plus the medication, plus the inflammation. And eventually the body just loses resilience. The encouraging part is that once you understand what's disrupting the gut, you can begin removing those gestures and creating conditions for healing. So once you understand what damages the gut, the next question becomes, how do you actually begin healing it? And this is where I always encourage people to keep things simple and foundational, because healing the gut is usually not about finding one magic supplement and doing some extreme protocol. It's about consistently creating the conditions where the body

can repair and rebalance itself. You wouldn't invest money without looking at the numbers first. You wouldn't trade for a race without knowing your starting fitness level. But somehow people spend thousands of dollars in enormous amounts of energy trying to optimize a body they've never actually measured. Cold plunges, red light, peptides, supplements. These tools can be generally powerful. But I always ask the same question that most people skip. What's your baseline? Because here's the truth. Trying to improve your health without your data is expensive guesswork. If your APOB is elevated, your cardiovascular risk deserves attention before your next protocol. If your vitamin D is low, your recovery and immune function

may be already limited. The most sophisticated move you can make right now isn't adding something new. It's knowing exactly where you stand. Function gives you access to 160 lab tests annually so you can understand what's happening inside your body before you layer anything on top. Data first, then decisions. Go to functionhealth.com slash mark, and if you're one of the first 1,000 people this week, use the code mark 2026 for a $50 credit toward your $365 a year membership. That's functionhealth.com slash mark and use the code mark 2026 today. And in functional medicine, we call it the 5R program. The first R is remove.

Remove what's irritating the gut, right? The first step is getting rid of the things that are continuously irritating and flaming the gut. And for many people, that starts with food, ultra-processed food, excess sugar, refined oils, addives, emulsifiers, excess alcohol. All these can disrupt the microbiome and they increase inflammation over time. For some people, certain foods may also be triggering immune reactions or digestive symptoms. We call these food sensitivities. And there actually are free allergies, but these are more food sensitivities.

And that's where an elimination diet can sometimes be really helpful, not forever, but as a short-term tool to help identify patterns and food triggers because here's a reality. You can't heal the gut while constantly irritating it. And I think this is important to say clearly. Healing doesn't require perfection. But reducing the daily inflammatory burden on the body can make a big difference. For people who want more structure and guidance, this is exactly why I created the 10-day detox diet.

It's simple. It's step by step. It's a program that's designed to help reduce inflammation to reset your gut, to stabilize your blood sugar, and remove many of the common foods and the habits that can disrupt the microbiome in your overall health. And one of the most powerful parts of the program is that you're not doing the loan. There's built-in community, there's support, there's education, there's recipes, there's coaching options, all help people stay accountable and support it throughout the process.

Because sometimes having a clear roadmap and support along the way, well, can make healthy changes feel so much more doable. I always say getting healthy is a team support. Now, a few of the things about the first are remove is not just remove bad foods or food sensitivities, but also remove bad bugs. could mean parasites, worms. It can mean treating what we call CBO or small intestinal bacterial overgrowth. That's when you get bloating right after eating or small intestinal fungal overgrowth or CFO, or often called use overgrowth or Canada. It's not just Canada,

by the way. And that's important. And those may require herbs, sometimes medications, and it's important to get all that stuff out before you start to rebuild the gut. Because there's a rule in functional medicine. If you're standing on a tax, it takes a lot of aspirin. If it can feel better, remove the tack. And if you're standing on two tacks, let's take out of food sensitivity, and a parasite, you got to take both them out. Removing one isn't going to make you 50% better. So really important to think about that, and you really often need the guidance of a good functional medicine doctor,

although there's some nice personalized protocols you can do that are herbal or don't require a doctor, but often you will need medication if you have things like parasites or worms or fungal overgrowth. The second R is to replace, and that's replace things that could be missing, like digestive enzymes, hydrochloric acid, and prebiotic fibers. Prebiotics are so important because they're the fuel for the healthy microbiome.

They can come from prebotic foods like asparagus, artichokes, plantains, you know, through some artichokes, lots of foods are prebotic. And then, of course, polyphenols are often overlooked. And these are the colorful plant compounds in food that feed healthy microbiome. So cranberry, pomegranate, green tea, things like that have major effects on the microbiome. So those are things you want to replace. The third R is to re-inoculate, and that means introducing and reintroducing healthy bacteria. And the second R that are replaced, the prebiotics and the polyphenols is going to feed the good bucks. But you've got to also sometimes give good bugs.

And that means things like probiotics. And there are many, many different kinds of probiotics. It's a very long conversation. I'm not going to go into it here. But it's important to understand there are different qualities of probiotics or different pro-botics for different things. and they all have different functions in the body. And so it's important to really understand what you're doing there. They don't usually take up residents. They kind of act like tourists. They change the economy while they're in there.

But they can be very symptomatically helpful. And I do use probiotics in my practice. The fourth R is to repair. Now, this is repairing the gut. And what often happens as a result of all this injury, bad foods and the lack of probiotic foods and fibers and the antibiotics and all the stuff that we do to the amateur gut, is that we get a leaky gut.

And that requires nutrients and things to help it repair. And things like zinc and vitamin A and omega-3 fatty acids and something called GLA, which is gamma linoleonic acid from ibuprimosol. It can also include things like glutamine and licorice and aloe and all kinds of different things that can help to repair the gut lining. And that requires often some supplements for a period of time. But it's usually a two-to-three-month protocol to help really reset the gut. And it's one of the most powerful things we do in functional management.

medicine. It's one of the foundational principles of functional medicine. An elimination diet plus a five-ar gut reset is often the key to so many health issues. So I encourage if you're having chronic inflammatory health issues of any kind, it's a powerful, powerful tool. And the 10-day detox is a great way to start. The dietary part, and then, you know, there's other resources we have on our website and online, Dr. Hyman.com, to help you understand what to do with healing your overall gut. And the fifth R is to restore. And that essentially means work with your nervous system because stress is a big disruptor of the gut.

If you take a bunch of healthy soldiers and you march them overnight by the morning, they're going to have a leaky gut and their microbiome is going to be messed up. Whether it's physical stress, psychological stress, it plays a big role. So learning meditation, yoga, breathwork, besides whatever your technique is and there's a lot of them out there, it's important to learn how to regulate your nervous system on a regular basis. Every morning I meditate, I do breath work, I do Qigong just to get my system, kind of in a good state. Of course, I screw it up the rest of the day, but, you know, how that goes.

And I try to come back at the end of the day, take a hot bat, relax, do all the things I need you to reset my system. So that's the five hours. Remove, replace, re-inoculate, repair, and restore. All right, let's talk about some other things that are important for the microbiome, eating foods that help your microbiome. I touch on a little bit, but the next step is to actively, feed the microbiome and support the microbiome. It's one of the most powerful ways that you can help

restore your microbiome is through food, and that's through dietary diversity. Your gut microbiome thrives on fiber-rich foods, on plant-rich-whole foods, colorful veggies, fruits, legumes, nuts seeds, herbs, spices, healthy fats, good quality protein, these are important. Now, these foods contain, except for protein and usually fat, they contain fiber and polyphenols that nourish beneficial gut bacteria, and they help create a healthier gut ecosystem. I often tell people eat the rainbow because different plant foods feed different microbial species and the more diverse your diet, the more diverse and resilient your microbiome becomes. Bad diversity is strongly associated with better overall health and lower inflammation.

Just think of a monocrop cornfield and how susceptible is to drought or pests or, you know, floods or whatever, versus a rainforest ecosystem, which is incredibly diverse, incredibly resilient, and if one plant dies, it doesn't really matter. Next, you should think about how to support your digestion. This is really important. How we eat matters, right? Not just what you eat. We live in a culture of rush meals, multitasking, eating in the car, eating while stress,

eating while scrolling on our phones, eating watching TV. You know, digestion is actually incredibly energy intensive. So slowing down matters, chewing thoroughly matters, eating in a commonerly. environment matters, hydration matters, because you can't properly digest in a fight-or-flight mode, you got to relax. And when the nervous system perceives stress, well, your digestion gets deprioritized. The blood's going to your muscles and your heart, not your digestion. And this is why so many people experience bloating, reflux, stomach discomfort, poor digestion during periods of chronic stress. Now, sometimes people may also benefit from targeted digestive support. It depends on the

situation, but the foundation is always supporting the body's natural digestive process first. Next, I want you to prioritize sleep and stress reduction. It's huge. The gut and nervous system are deeply connected. So when stress hormones like cortisol are elevated chronically, well, they alter the microbiome. They increase inflammation. They affect intestinal permeability. And they disrupt digestion. And honestly, many people underestimate how much stress impacts the body physically, not just mentally. Stress changes biology. And that's why I practice is like walking, mindfulness, breath work, time in nature, social connection, restorative sleep can have profound effects on gut health. Sometimes the most healing thing for the body is creating more safety and regulation in the nervous system.

The next thing I want you to consider is targeted support for your gut. We talked a little bit about this, but I want to dive in a little more here. There are situations where it can be really helpful. That includes probiotics, fermented foods like sourcrow, kimchi, miso, natto, debate, omega-3 fats, important, like I said, for the gut glutamine. All these things are important. Zinc, they can really, really be important, but don't over-complicate things. There's no single supplement at the heels of gut. Supplements support the process, but they work best when the foundations are already in place. Real food, sleep, stress reduction, nervous system regulation,

reducing inflammation, all are so key. Because ultimately the body already knows how to heal. our job is to remove what's interfering and provide what's needed for that healing to happen. All right, let's a little quick Q&A, common questions. Are probiotics necessary? Well, some of those are helpful, but food and lifestyle come first. Prebiotics are more important than probiotics. That's a good one to remember. And polyphenol is also important.

What's the best diet for gut health? Whole foods, fiber-rich, anti-inflammatory diets help most people. Okay, how long does gut healing take? It depends on the person, but consistently matters more than perfection. It can be usually one to three months. Can stress alone affect the gut? Absolutely. Is leaky gut real?

They used to make fun of me for talking about it, but actually it is. Just go on PubMed, the National Library Medicine database of all scientific papers, and search for intestinal permeability. A big scientific word. Essentially, it means in English, leaky gut. It's well documented and no longer are people laughing at me. Thank God. I don't care what they do anyway.

So as we wrap up, I want to leave you with this. Healing the gut is not about perfection. It's about restoring balance. The body has an incredible capacity to heal when we take away what harms it and we give it what it needs. Take away the bad stuff, put in the good stuff. That's it. And often the most powerful changes are often the most foundational.

Eating real food, reducing ultra-processed food, supporting the nervous system, prioritizing sleep, managing stress, moving your body. creating a healthy relationship with food and your health overall. In fact, it works for everything, right? Start simple. You don't have to do everything at once because small daily habits have a powerful cumulative effect on the gut and your entire body, actually. This is really what functional medicine is about.

It's about helping people become the CEO of their own health. It means learning how your body works. It means paying attention to what's telling you, listen to your body, and understanding what your daily choices are and how they matter more than any one medication or supplement or quick fix ever well. And when you begin supporting the body consistently, amazing things can happen because when you heal the gut, you're often helping heal the whole body. Thanks for joining me for office hours. I love diving into these topics with you. Remember, you are the CEO of your own health. And every choice you make can move you closer to healing

and vitality. I want to keep these episodes as relevant and useful as possible. So tell me, me, what do you want to explore next? What questions are you wrestling with? What breakthroughs are you chasing? Share your ideas in the comments on social media or through the link in the show notes. I'm listening. Until next time, keep taking charge, keep asking questions, and keep showing up for your health. If you love this podcast, please share it with someone else you think would also enjoy it. You can find me on all social media channels at Dr. Mark Hyman. Please reach out. I'd love to hear your comments and questions. Don't forget to rate, review, and subscribe to the Dr. Hyman Show wherever you get your podcasts. And don't forget to check out my YouTube channel at Dr. Mark

Heimann for video versions of this podcast and more. Thank you so much again for tuning in. We'll see you next time on the Dr. Hyman Show. This podcast is separate from my clinical practice at the Ultra Wellness Center, my work at Cleveland Clinic and Function Health, where I am chief medical officer. This podcast represents my opinions and my guest's opinions. Neither myself nor the podcast endorses the views or statements of my guests. This podcast is is for educational purposes only and is not a substitute for professional care by a doctor or other qualified medical professional. This podcast is provided with the understanding that it does not constitute medical or other professional advice or services. If you're looking for help in your

journey, please seek out a qualified medical practitioner. And if you're looking for a functional medicine practitioner, visit my clinic, the ultra-wellness center at ultra-wellnesscenter.com, and request to become a patient. It's important to have someone in your corner who is a trained, licensed health care practitioner and can help you make changes, especially when it comes to your health. This podcast is free as part of my mission to bring practical ways of improving health to the public, so I'd like to express gratitude to sponsors that made today's podcast possible. Thanks so much again for listening.