The Dr. Hyman Show - The Science Of Increasing Lifespan And Optimizing Healthspan with Peter Diamandis

Episode Date: December 13, 2023

Get Free Weekly Health Tips from Dr. Hyman Sign Up For Dr. Hyman’s Weekly Longevity Journal Get ad-free episodes & Dr. Hyman+ audio exclusives Peter Diamandis is a serial entrepreneur, futurist, technologist, New York Times bestselling author, and the founder of more than 25 companies. Fortune magazine has named Peter “one of the World’s 50 Greatest Leaders,” and he is the Founder and executive chairman of the XPRIZE Foundation, which has launched more than $300 million in incentive competitions, driving more than $3.5 billion in R&D (most recently launching the $100 million Gigaton Carbon XPRIZE funded by Elon Musk to combat climate change). Peter’s venture fund, BOLD Capital Partners, is deploying $600M+ into exponential technologies and health-biotech. Peter has written four New York Times bestsellers, and his life’s mission is to empower entrepreneurs to create a hopeful, compelling, and abundant future for humanity. This episode is brought to you by Rupa Health, Joovv, Sunlighten, and Cozy Earth. Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com. For a limited time, Joovv is offering listeners an exclusive $50 off their first light therapy order. Just go to Joovv.com/Farmacy and use code FARMACY. Right now, you can save up to $600 on a Sunlighten infrared sauna. Just go to Sunlighten.com/Mark-Hyman and mention my name. Right now, you can save 40% when you upgrade to Cozy Earth sheets. Just head over to CozyEarth.com and use code DRHYMAN. We discuss (audio version / Apple Subscriber version): The power and importance of one’s longevity mindset (7:40 / 5:22) Staying alive and healthy enough to reach longevity escape velocity (8:13 / 5:55) Debunking the myth that genetics are the main predictor of lifespan (12:57 / 10:39) Do’s and don’ts of eating for health and longevity (17:30 / 15:12) The best exercises for longevity (23:04 / 20:46) Optimizing sleep (30:56 / 26:48) How not to “die of something stupid” (35:52 / 31:44) Peter’s personal “Longevity Practices” and cutting-edge technologies coming online (45:34 / 41:26) My thoughts about Ozempic (56:24 / 52:20) XPRIZE Healthspan (1:01:54 / 57:46) Get copies of Longevity: Your Practical Playbook on Sleep, Diet, Exercise, Mindset, Medications, and Not Dying from Something Stupid. Learn more about XPRIZE Healthspan.

Coming up on this week's episode of The Doctor's Pharmacy. 7% to 30%, and there are different studies giving different numbers, of your potential lifespan is a function of your genetics. The vast majority, 70% to 90%, is a function of the choices you make your lifestyle. Hey everyone, it's Dr. Mark. I have a question for all you healthcare practitioners listening to this show. How much time do you spend ordering functional medicine lab tests? Well, lab work is a critical tool for functional medicine. It helps practitioners find the root cause of illness, but the process of ordering, managing, and tracking lab results can take hours of time

away from actually caring for your patients. And that is why I want to talk to you about Rupa Health, the absolute best way to order testing from over 30 different lab companies like Genova, Dutch, DSL, and lots more. Rupa makes ordering labs ridiculously simple, which means not only are you able to spend less time on tedious processes, but it also allows you to provide a higher standard of care for your patients. If you're not already one of the tens of thousands of healthcare practitioners using Rupa Health, make sure to go sign up for a completely free account at rupahealth.com. That's R-U-P-A health.com. As you know, I'm a huge proponent of a well-rounded lifestyle, including whole foods, exercise, and sleep. But one great modality to add to your arsenal

is light therapy. One of my favorite tools for my wellness routine is the Juve Red Light Therapy, which personally has helped my sleep. That's J-O-O-V-V. Light actually plays a key role in the function of our circadian rhythms and sleep patterns. Red light therapy is an amazing tool to reverse aging through mitochondrial support, as well as reducing inflammation, boosting mental acuity, and supporting healthy skin. Personally, I like to use my JOOV at night to wind down from the day. And all devices now have ambient mode for calming lower intensity light at night. That's way healthier than bright blue light from all our screens and it's more in line with our natural circadian rhythms. Ever since I've been using JOOV's at-home red light

therapy devices, I've noticed I get deeper, more restful sleep and I feel more energized and focused during the day. I just sit or stand in front of my JOOV for 15 minutes a day. That's it. If you're ready to get a JOOV today, you're in in luck because Juve's holiday deals are now available. Juve is offering big discounts in this holiday season on all Juve devices, including their popular Juve Solo. But act fast because this amazing sale ends on Friday, December 22nd. Visit juve.com forward slash pharmacy to take advantage of these holiday deals. That's juve.com forward slash F-A-R-M-A-C-Y. Don't miss out on this limited time offer. Sale ends December 22nd. And now let's get back to

this week's episode of The Doctor's Pharmacy. Welcome to The Doctor's Pharmacy podcast, a place for conversations that matter. I'm Dr. Mark Hyman, and today we have the privilege of talking to one of the leading thinkers and doers in the world, Dr. Peter Diamandis. If you care about learning the practical steps to increasing your healthspan and your lifespan, you're gonna love this podcast. Peter is a serial entrepreneur, futurist, technologist,

New York Times bestselling author, and the founder of over 25 companies. Fortune Magazine has named Peter one of the world's 50 greatest leaders. He's the founder and executive chairman of the XPRIZE Foundation, which has launched over $300 million of incentive competitions, driving more than $3.5 billion in R&D, most recently launching the $100 million gigaton carbon XPRIZE to combat climate change. Peter's venture fund, Bold Capital Partners, is deploying $600 million into exponential technologies and health biotech. Diamandis has written four New York Times bestsellers, and his life's mission is to empower entrepreneurs to create hopeful,

compelling, and an abundant future for humanity. Now, if you're a regular listener to this podcast, you know one of my main interests is applying the latest science and technology in the field of longevity to not only optimize how long we live, but how vibrant and healthy we are as we age. And Peter and I explore the power of mindset for health and longevity. We dive into the concept of longevity escape velocity or how the science is advancing so fast that at some point soon we can escape the decline normally associated with getting older. We also explain why foundational health practices that optimize your lifestyle are more important than ever before so we can be alive when longevity escape velocity is reached.

We also bust the myth that how long we live is mostly dictated by our genes and we dive into how to turn the latest science into actionable steps and habits that you can use now. The best strategies for what to eat, how to exercise, how to optimize sleep for longevity. We also explore the most important diagnostic tests to track and measure your rate of aging and health and how to use personalized medicine to get ahead of the issues and diseases before they fully develop. We also spend some time talking about Ozempic and I share my thoughts about the pitfalls and risks of this drug and we explore the question of whether Ozempic is also a longevity medicine. You'll hear about Peter's personal longevity regimen and how the molecule rapamycin

and various peptides and supplements and cutting edge technologies like therapeutic plasma exchange are all coming online now. Peter also tells us about his $101 million X Prize that he launched to revolutionize the way we approach human aging. Peter is literally the author

of the practical playbook on longevity. And our conversation today will leave you with actionable and free tips to set yourself up to benefit from the leading research in the field of longevity, as well as a look into the next generation of therapeutics. And now let's dive into my conversation with Peter Diamandis. Welcome back to the podcast, Peter. It's great to have you and great to see you again, looking younger than ever. Thank you, Mark. You know, is that a requirement when you're on a longevity podcast or having a longevity conversation? You have to tell the person, you look amazing. I'm fantastic.

What are you doing? You've got to tell me your first calls. I know it was like three hours of makeup before. So for those of you who are listening, you can't see. But Peter looks beautiful. He's got purple lipstick and red eyeshadow. It's amazing. Peter, I'm so glad to have you back because you came out

with a book called Life Force with Tony Robbins. It was just amazing, but it was 700 pages and not for the faint of heart. Now, I read every word of it and I actually studied it in depth, which was a great book, but you came out with a new kind of Reader's Digest version called Longevity, Your Practical Playbook on Sleep, Diet, Exercise, Mind, medications, and not dying from something stupid. So that's a good idea, not dying from something stupid. And I think it's beautiful because it's like the news to use. It's the nuggets of information that we all want to know. What do we do? How do I do it? What's important? What's noise? What's signal? And how do we figure out what we need to do to optimize our health? And human life expectancy is one of the most incredible breakthroughs in modern medicine, right? We've seen our life expectancy dramatically go up since the turn

of the 1900s. And unfortunately, now it's starting to go down. It's starting to go down. We see a little pop-up this year, I think, because of the post-COVID recovery. But basically, we've more than doubled the global average lifespan in the last 100 years. But our healthy life years have not increased at the same rate. There's a lot more sicker people at the end of their life. So their healthspan doesn't equal their lifespan. And what's happening is our world's population is growing, and our aging population is growing even more.

So people over 60 are expected to double from 12 to 22% between 2015 and 2050. So we got to find solutions to not only improve our lifespan, which is, I guess, important, but what's more important is how do we improve our health span? How many years of life that we have that are healthy? And for most people, the last 20 years of their life is spent in poor health, which means let's say you're, you know, live to be 80, some 60 years old, you got some chronic disease or another. So you've written this important manual and you talk about this health span revolution. So why does it matter? What is it and why now? So I think what I'm hoping to do is to impact

people's longevity mindset. You know, I think you can will yourself to live and will yourself to die. I think your mindset is so fundamentally important. And my mission here is for people to realize we're in the middle of a health span revolution, that the convergence of technologies like AI, sensors, networks, gene therapies, epigenetic reprogramming, cellular medicines, all of these things are making and will continue to make a massive dent. There's a topic we've spoken about before, and hopefully folks have heard the term of longevity escape velocity, that today for every year that you're alive, if you're reasonable socioeconomic and reasonably taking care of yourself, science has the potential to extend your life for somewhere between a quarter to a third of a year. And there's going to be a point in the future where for every year that you're alive, science is extending your life for more than a year.

And that idea is called longevity escape velocity. When I interview my dear friend Ray Kurzweil, with whom I'd started Singularity University, Ray's expectation is that we're going to hit longevity escape velocity in just 10 to 12 years. Talking to George Church. But that means you can never die. The theoretical aspect of it is that you keep extending your life. And I'm not so sure about that. Well, so I think the point is not immortality, but everything that is possible is being made available to you to maximize your health span. So, you know, one of the things that hit me when I was in medical school, God knows, you know, a few decades back.

Just a few decades back was- Just a few. A few. You and I both. You actually became a real doctor. I had two companies going my fourth year of medical school, a space university and a rocket company. Not your typical internship. Anyway, but I remember learning that bowhead whales could live 200 years and Greenland sharks could live 500 years. And you've heard me say this story a thousand times. And if they could live that long, why can't we?

It's hardware or software. And so this is the decade that we're making a large functioning molecular machine. We're quantum, you know, quantum chemistry at I both do, wouldn't you want to be around long enough to intercept these? You don't want to be the last person before the new nanotech revolution comes around and says, oh, my God, we can reverse all these things of aging and reset. So the idea for this book is, listen, there is, we're in the midst of a healthspan revolution. There's more capital flowing in by 10X over the last 10 years into longevity. There are more tools and technologies. The cost of genome reading, editing is plummeting. And so because those things are coming, you probably should keep yourself as healthy as you can intercept these technologies.

And there are a number of things, you know, Ray Kurzweil talks about a bridge to a bridge. Bridge one to getting to longevity escape velocity is doing certain things around sleep, diet, exercise, mindset, not dying for something stupid. Bridge two, are technologies accessible to us today, like stem cells, and perhaps exogenous natural killer cells and other things. And step and stage three, or bridge three, is going to be those technologies that are, you know, a decade or two away. And so that's what this book is about. I wanted to make it, uh, you want people to get to live long enough to get to longevity. It's like, listen, do these things. I mean, I've read hundreds of books, uh, at the end of the day, I try and take notes, but you know, there are certain things which are just fundamental and certain things that depend upon, you know, what your genetics are, where you were

born, your other situations in life. And so I just wanted to make it super easy. My target was a hundred pages. It turned out to be 120 pages, but I think it's, it's a practical playbook. That was the goal. Yeah. Yeah. It's really, It's really great. And I think I want to get into the nitty gritty meat of it because I think everybody knows that there's some basics that we all have to follow. And then we're going to get into, in a kind of rapid fire popcorn way, a lot of the cool things that people may or may not have heard about that are on the horizon that you're using to optimize your own. Something I'm actually using myself, very similar.

I was shocked at how similar our programs were. I was like, wow, we must be. Dude, I learned from you. I learned from the best. I was like, wait a minute. Okay. So- I'm paying attention. It's so true. I mean, yeah. And one of the things that people don't understand is how much of it is under our control, right? 90 plus percent, I think is under our control. Can we just, can we hit that one second? Because people say, well, my parents died early and so forth. When you look at the numbers and it's somewhere between 7% to 30% and there are

different studies giving different numbers of your potential lifespan is a function of your genetics. The vast majority, 70 to 90% is a function of the choices you make your lifestyle. You do have functional control over this. You don't have an excuse. Yeah. Well, you know, Peter, it's interesting. This morning, I actually had a chance to review my own genetics and I've done my whole genome sequencing, but that's like, you know, 30, 20, 30,000 genes. It's, you know, it's impossible to get your head around. And I did a subset of about 700 snips or variations of my genes. And it was with a company that's doing an incredible job of actually mapping out the most common snips that are actionable. In other words, even if you have genetics to predispose things, for example, I discovered that I have this gene that predisposes to B-cell lymphoma, which my sister had. And it makes you much, much higher risk of getting this

particular lymphoma. But it also was so interesting to see how they looked at all the scientific literature and mapped out what are the interventions that affect this gene and change the gene expression. For example, maybe resveratrol affects this pathway and this gene expression. Or I had another gene that regulated vitamin D and I noticed a surprise when I was in my 50s. My bone density was low and I was a runner and I was lifting weights. I was doing yoga and very athletic and I shouldn't have had low bone density, particularly as a guy. And I found out, I had this gene that affects osteoporosis and vitamin D receptors. And I was able to sort of see, oh, I know I need to take a lot more vitamin D than the average person. So I figured that out

on my own, but my genes can give me a guide to how to even optimize my genes. So even though it may not be genetically predetermined, you might have a predilection, right? And so you actually have control over it. And that's what's even more interesting is that even if we have genes that are kind of problematic we can modify the expression of those genes so it's super cool and we do it remember which company that is by the way yeah it was called intellix dna and uh it's it's really driven uh through a functional medicine practitioner base because it's very complicated most doctors don't have the patience or time for it. And you can segment the genes based on mental health, ADD, inflammation, nutrition, cardiovascular risk, and so forth. So it was really quite fascinating. So I was just looking

at it myself and learning about it and seeing what's always new on the horizon and applicable for my patients. And I was like, wow, this is a different, whole different level of looking at the DNA because it wasn't really just looking at the SNPs. It was actually telling you not only what they meant and what their risk factors were that maybe you were predisposed to based on these genes, but actually what you could do to modify that gene expression. But the truth is that most of the things that were included were foods. I know I need to eat two ounces of pomegranate juice because it affects this one gene that puts me at risk for, you know, cardiovascular disease, right? You know, I need to take, you know, more curcumin or, and it was really interesting to see how there's a lot of data

on these things. And by the way, this is fantastic. And we, you know, even though we've sequenced the human genome, we're continuing to learn about your genome, everybody's genome, every single day as different relationships are discovered. And there's going to be a time sometime in theisms, your SNPs, will be guiding. If you turn on the function, it will be guiding you every minute of the day on what to eat, what to do based upon your current genetics, your blood chemistry, your objectives. And it becomes a super hyper-personalized if you want that. Yeah. And I think that's right.

And I think they hadn't even applied AI to this model. I was like, wow, once you do that, you're going to get a hierarchical set of recommendations that you can implement that are actually doable. And then you can measure the results and see how you feel and what's going on in your biology. But the basics of changing these gene expressions, which are epigenetics, is really about our lifestyle. And that's the foundation of the beginning of your book, is what we eat, how we exercise, sleep optimization, and then we get into kind of a bunch of other stuff. So let's start with just the basics of what are the do's and don'ts for eating. And let's start with that. We want to live a long time. This is like a lowly priest talking to the Pope about what to eat.

I'm not the Pope. I'm Jewish, for God's sake. Okay. For God's sake. Okay. Fine. I'm not sure I understand. The rabbi. the rabbi. What's the highest rabbi out there? Listen, and tell me where I'm off, but I wanted people to have, it's one, two, three, too many. At the end of the day, if you need to memorize, oh my God, this, that, and the other thing, what are the fundamentals? And the most important fundamental is sugar is a poison.

We never evolved to eat as much sugar and so i really have eliminated um not everything but 95 99 percent of sugar for my diet right i will have a small piece of dark chocolate if i eat something i'm going to take the moment in time to actually enjoy it. And I'm not stuffing my face. You know, it's whole plants, as you've said so many times. One of the things I wrote about in there that I love is the order in which you eat your food. Yes. Can matter.

Exactly. I mean, so you go out to the restaurant and they bring you a basket of bread and wine. And it's like, oh, my God. It's like the worst thing they could possibly do for you. It would try to kill you. So ask them to bring it back when the main course comes instead of eating it right then and there. Well, they know that it makes you hungrier and eat more. So you order way more food and dessert.

You have to make the request. You have to make the request. And like I'm at a party and everybody serves dessert and they put the plate in front of you i have gotten so good at like just catching and saying no stop go away put you know don't if it's sitting in front of me my willpower will erode if it's not there then i'm good but uh going back to the order of the food you know on your plate you're gonna have veggies protein and carbs likely they eat your vegetables first your fiber first it slows down digestion your protein next and and then eat your carbs last um and your absorption of nutrients and your desire to eat the carbs everything improves or your lack of desire to eat the carbs everything improves when you eat in that order yeah and then there's always that glass of water you drink before you

consume your meal so why we talked about you know timing an order of food cutting out sugar eating more vegetables and plant food basic basic stuff what about what about protein and fat so this is a conversation i want to ask with you so i I'm on a mission to add muscle, right? And so I am on a high protein diet and I'm targeting, I weigh 150 pounds, I'm targeting 150 grams a day. And I looked at the studies on intermittent fasting and it didn't look that like intermittent fasting actually made a substantial difference other than reducing your total caloric intake. And so getting enough protein in my diet, when I'm not eating, when I'm eating just between one o'clock and six o'clock,

was it was difficult. So I cut out my intermittent fasting and increase my protein intake. What are your thoughts on that? And how you feel and what's your body great i feel great and i've added more muscle i've added i've added five six pounds of muscle i'm trying to get to 10 i'm pushing you know i'm increasing my workouts from three a week to five a week uh my creatine you know um i mean the proof is in the pudding you feel better you have more muscle it's your body is i always say that your body is the smartest doctor in the room. So you could have an ideological view that you should be a vegan or you should, you know, eat tons of meat or you should whatever.

You have to try it out and see what happens, right? Because your body is going to tell you if you feel better, if you look better, if you're stronger, you're building more muscle, if your biomarkers are better, then that's your answer. You know, I always say, don't let your ideology run over your biology, you know? And we're all different. And some people, I mean, I know if I don't eat enough carbs, like sweet potatoes and things like that, I'll just drop too much weight. And so I don't want to do that. So, and I need to eat more fat and more protein. So I think, I think it's really about listening to your body, But conceptually, I think as we age, you need more protein to overcome what we call anabolic resistance, which means it's

harder to build muscle as you get older. So you need more workouts, more protein, and you probably need more high-quality protein, mainly animal or whey protein. And you need probably something like creatine to help boost it. And you need to exercise usually within an hour to take a protein load about 40 to 50 grams an hour to after your workout. So that's a great formula. And I noticed when I'm on the road, and I can't do that, I lose muscle when I'm at home, and I'm doing the same workouts. And I do that, I gain muscle. So it's pretty reliably there. And I think, you know, people are confused about the autophagy was like, well, you should inhibit mTOR. And we'll talk about some of the things about that in a bit. But I think that that's kind of a big meme in the longevity space, which is you want to inhibit mTOR to

increase autophagy and self-cleaning. It's like, it's the way your body accelerates self-cleaning and repair, which is great for longevity, but it also has a dark side, which if you do too long and too much, you lose muscle. So you need, it's like, by the way, I don't know if you recognize this packaging. Um, it's, I'm on day two of my prolon, uh, fast. I do, you know, a couple of times a year. Oh, that's, that's, that's great. Okay. So, so that's food. What about, what about exercise? Cause we just talked about your muscle mass and I think that's, when it comes to longevity, I think muscle mass is, is the unsung hero. It is. It's, you know, exercise, you know, the numbers it's, uh, if you're over 60, the number one thing you can do to maximize your longevity and reduce your cancer, a chance of cancer by threefold your chant your you know overall chance

of mortality by by twofold is exercise you know get in a couple at least a couple of days a week of resistant exercise for half an hour if nothing else um for me i'm you know i belong to three different gyms i've got there is no excuse there is zero excuse you got two different trainers and it's like i just have everybody just you know i pay for all of this so i don't give myself the excuses for not working out and um when i'm on the road uh i actually have uh yanni on my team who travels with me he's a young phd and supports me across everything I do. It's like, I'm like, we're going to the gym at 6 a.m. He goes, no, I got to get some sleep. I said, no, we're going to the gym at 6 a.m. Get to sleep early. And so it's a priority. I think

I have never had exercise this much of a priority in my life than I do at 62 years old. And I feel great. You know, I've got two 12-year-old twin boys, and they are exercise for me as well. So, you know. So that's joyful. I think that's important. Like, you know, I think, like I always say, you can drive a Toyota Camry off the lot and drive it for 100,000 miles and never touch it. But if you've got a 1959 model, what you 1961 model i'm a 59 model you know

i mean you know you can't just drive it around and not take care of it and and change the oil more and get it tuned up more and make sure everything's lined up more and so so it just takes a little more effort as you get older and And I think it's not impossible, but it requires much more focus. And you have to want it. You have to love it. You have to have a purpose for it. And for me, you know, it's interesting, right? People say, well, how old do you want to live?

You know, my friend Dan Sullivan wants 156. When I was in medical school, I learned that certain species of, you know, sea life could live 700 years. So I said a ridiculous number of 700 years. By the way, if you can make it an extra 30 years from now, I think you're going to intercept so many breakthroughs that buy us a century if you want it. What my mission is to arrive at that point of longevity,

escape velocity, and great health, whenever that is. I think that's true. And it's also, for me, the definition of health is really simple. It's being able to get up in the morning and do whatever it is that I want to do. If I'm visiting my daughter and she lives in Salt Lake City and she says, Dad, I want to go on a nine-mile hike up to 9,000 feet elevation. Can we go? I'm like, sure.

And we ran up the hill. I got all the way up. And it was actually funny because I actually made fine. And then I realized that I had the time zones wrong and I thought I had a call and there was no service. So I only ran down the mountain, which at 64, there's a lot of stability issues and a lot of risk of falls. And if you don't maintain your stability as well as your strength and flexibility and cardio. And I was able to just go down like a mountain goat. And it's not because I'm superhuman,

it's because I've been training for doing the thing. I don't do my band exercise to do my band exercise. Okay, I like to listen to music, listen to podcasts. I've gotten to like it. But it's not like my fun thing to do. I wanna play tennis. I wanna hike up to the Himalayas. I want to go riding across the Mongolia on a horse.

I want to do whatever I want to do and not stop. And by the way, the number one thing for you and I to be concerned about more so than someone who's in their 20s or early 30s is injury, right? Injury is the biggest issue. Fall, break your pelvis or hip, end up in the hospital and with pneumonia and you're screwed. And the mortality for someone breaking their hip in a year is 50%. So if you break your hip, you're 50% likely to die in that year after which is staggering it's like worse than getting terminal cancer for people over 60 i think the number is yeah yeah so got exercise i love your routine

and you you go through exactly what you do in the in the in the book yeah one other thing is is your aerobic exercise right so zone two training um and i talk about in this you know what you want to do is you want to stimulate mitochondrial growth and you want to stimulate it. And, and the, there's a, there's something called zone two training where your heart rate is at a particular band. For me, it's at about 110 to 115. I show you how to calculate that. And so I've got a stationary bike, a Technic gym bike, and there's absolutely no excuse to take a board meeting or a phone call sitting on your butt. I mean, I'm feeling guilty sitting down and doing this with you right now. Well, the podcast would look funny if we were both bouncing up like this.

I'd be somewhat out of breath. But, you know, I remember tweeting out sitting is the new smoking. And it really is. I mean, we sit in front of these damn zoom conversations for most of the day and uh it's abusive to your body yeah so yeah for sure yeah i just wanted a beautiful hour and a half walk up the mountain this morning and maybe i got a little over zoned too but it just keep moving or you don't like you i met this guy who was 95 once peter and he was he was like bouncing around like a spry 50-year-old. He had a 20-year-old younger girlfriend. And I'm like, what's your deal?

And he was eating bagels and lox at this thing. I'm like, what's your story? He's like, well, whatever I did yesterday, I do today. If I played single tennis yesterday, I do it today. I mean, if you ride your bike 20 miles every day, you're going to keep being able to ride your bike 20 miles every day as long as you live, right? So just don't stop. Hey, everyone. It's Dr. Mark here. Optimizing your health and wellness is a lifelong journey and we all know how important things like

proper nutrition and exercise are to live better. But I want to talk with you about another foundational tool for optimizing wellness that often gets overlooked. Infrared saunas. Infrared saunas are extremely effective at reducing the body's stress response and creating balance in the autonomic nervous system. They can improve circulation, help with weight loss, balance blood sugar, improve detoxification, each of which improves your brain function. When it comes to infrared saunas, my number one brand is Sunlighten. Whether you're craving relaxation or deep sleep or detoxification, Sunlight infrared saunas will help you achieve your health and wellness goals. From weight loss to muscle recovery and skin rejuvenation, their patented infrared technology will restore your body and your mind. Right now, you can save up to $600 on your purchase.

Simply visit sunlightin.com forward slash mark dash hyman and mention my name, Dr. Hyman, to save. Getting quality sleep is incredibly important to me. Sleep is really one of the pillars of good health. So you can imagine my frustration when I used to lie down at night, but couldn't fall asleep because I was just too hot. But those sleepless nights are behind me now thanks to Cozy Earth. The bed sheets are made from temperature-regulating fabric

that keeps you comfortable all night long. I naturally run hot, but with Cozy Earth's breathable sheets, I cool off and get right to sleep and stay asleep much faster. Cozy Earth offers a variety of luxury pillows, sheets, blankets, and more, and their durable weave fabric won't pill for 10 years, guaranteed. Plus, they pride themselves on the ethical production of all their products, so you can feel good about your purchase knowing you're supporting a truly responsible company. And right now, Cozy Earth is providing an exclusive offer for my listeners.

You can get 40% off site-wide when you use the code DRHYMAN. Just go to CozyEarth.com and use the code DrHyman. That's D-R-H-Y-M-A-N. And now let's get back to this week's episode of The Doctor's Pharmacy. Now, the other thing that's really important, Peter, you talk about, I think is sort of one of the unappreciated and most important aspects of health is sleep. And a lot of people have sleep issues. There's 70 million people with sleep issues in America. There's, you know, so many people struggle with falling asleep, staying asleep, waking up early, getting up in the middle of the night. What's your personal story about your transformation of your sleep and your routine? Yeah, I love, I love this. So I am lucky to be a reasonably good sleeper. I just came back from Saudi Arabia.

So I was 12 time zones away. And so I'm in the middle of shifting myself back. I was up at 3.30 this morning. But I went to sleep at 8.30 last night. So it wasn't too bad. The body needs eight hours of sleep, at minimum seven hours of sleep. One of the things I tell people is when you're sleeping, you're not reproducing, you're not hunting for food, you're not protecting yourself,

you're very vulnerable. If evolution could have done away with that extra hour of sleep, it would have. So the fact that it hasn't means you need it. And so what do you do? There are certain, I go through the basics here. I'll tell you the most important things. Number one, it's going to sleep at the same time every night. It's consistency of going to bed because typically your body wakes you up at the same time. And so my body, I'm up and awake at 5.30 or 6 a.m. in that band. And if I go to sleep at 9.30, I'm good. But if I happen to go to sleep at 11 o'clock

at night, I'm screwed. I can control my go to sleep time. The other things are I use a Manta mask. I love this mask. It has foam around the eyes and it's a beautiful mask. It seals it out. I set the temperature in my room to 63 degrees Fahrenheit, which is pretty damn cold. I use an eight sleep. You know, there's lots of different cooling mattresses. And then at the end of the day, I also use a mouth guard, which is a mandibular adjustment device. It moves my mandible out a little bit and keeps me from snoring and keeps my open airway and keeps me as a nose breather versus mouth breather.

And you do some other things, right? You block the light at night. You measure your sleep. You don't eat before bed. You don't have caffeine in the afternoon. These are just basic sleep hygiene principles, right? Yeah, it is sleep hygiene. I don't eat two hours before. I'm not drinking water an hour before. I've given up most all alcohol, maybe a glass of wine every couple of weeks. How about you? Yeah. Well, it's interesting. I wear this Oura ring and I track my sleep and I'm like, damn, I drank that wine and my sleep was messed up. My heart rate didn't go down. My heart variability plummeted. I'm going to look like I was in some severe stress response. Yeah. And it's like, it's interesting to get that feedback

because I wouldn't, you know, you wouldn't have known otherwise. Right. So I really have minimized it. Maybe I'll have a drink a month if I'm out or, you know, a shot of tequila, but that's about it. Maybe I'll have a drink a month and come out or a shot of tequila, but that's about it. That's exactly the same. And on the sleep, by the way, I use my Oura Ring. It doesn't do anything to get me to sleep or to give me better sleep, but it makes me aware. So if I'm deciding whether or not to have something to drink or deciding if I'm going to grab that snack, I'm thinking to myself, it's going to screw with your sleep tonight and you're going to see it on your data in the morning. So, it's just what you don't measure, you don't actually impact. So, we measure it that way. I'm curious, my heart rate when I'm sleeping is like 38, 39. It drops down really, really low. And- I mean, that is low. I mean, what's your resting heart rate during the day? Probably 55.

Well, that's good. I mean, that's good. I mean, if your heart rate was 70 and dropped to 30, that would be, I would worry about some kind of heart block or something like that. But you probably should have an EKG, but I'm sure it's fine. I've had so many from Fountain. Yeah, I think cardiovascular, I'm okay. But it was interesting. It was like, okay, don't go any lower. A certain number of heartbeats in your life, I'm going to keep them.

Although I did a podcast with deepak chopra yesterday he's like basically the the the uh the ancient hindus and the yogis who live to be like they say 180 or whatever they said he said they measure their life not in years but in heartbeats and breaths so you kind of have to go slow yeah and i don't know if that's true but it sounds good. All right. So, you know, one of the things that you're involved in is, and by the way, there's so much more we're going to talk about in a minute, but I want to touch base on not dying of something stupid because that's basically the subtitle of your book. And what do you mean by that?

I think you're referring to basically tracking your biomarkers and your biology and your imaging tests. So you know where you're at and that you don't die of something that's totally preventable. And, and, uh, you know, we, do we use, you know, I mean, one of the things that shocked me was reading, you know, if you're, if you're 35 and you smoke two packs of cigarettes a day, your risk of getting cancer is far lower than if you're a seven-year-old and you don't smoke at all. right? Because it's just age is one of the biggest risks. And same thing with heart attacks. So here's how I think about not talking something stupid. First of all, you know, wear your seatbelt in the car. Don't text while you're driving. Wear a helmet while

you're going skiing, right? Those are like the basics. But here's the other part. And it really, it bothers me how few people understand this. Your body is amazing at hiding disease, right? You don't feel anything until you have a stage three or stage four cancer. 70% of heart attacks have no precedence, no shortness of breath, nothing on imaging. It's a soft plaque that evulses and kills you. The first symptom of heart attacks for 50% of people is sudden death. Yeah.

I mean, it's like, that sucks. So if you don't have Parkinsonian tremor until 70% of the substantia nigra neurons are gone. So again, your body's really great at hiding any symptoms of something wrong going on. And so when you ask people, are you in good health? Is there anything you need to worry about? Most people say, yeah, I'm fine. But you don't actually know until you look. And then people say, well, I don't want to know. I was like, of course you want to know. I mean, you're going to know. Do you want to know when it's too late to do something or you want to know when you can do something about it? So- You know, Peter, before you go to the next thing, I just want to emphasize something

because what you're saying is really important. In medicine, we are trained in medical school to not look until something's wrong, except for very few things like screening for cholesterol, screening for breast cancer mammograms, colonoscopy, pap test, but very few things. And we're taught, you know, we don't want to over-test. We don't want to over-diagnose. We're going to pick up things that are going to be red herrings. It's bad medicine. And you only want to do a test when you want to confirm a diagnosis, which means that you're not picking stuff up until very late. Like you said, it's like it's like it's like you know the you kind of like a glass you're filling up it's that doesn't spill over until the very end and you're you know by the

way though you're filling it up the whole way and it and that's really what's happening in medicine and so there's a chance really now with our technologies and what you've developed with fountain life to really dig deep and to kind of look at your body in a way that we've never 100 before and not be that. And it just reminds me of this one patient who said, Dr. Hyman, I want to get a check. I'm like, okay. And we checked his blood sugar was like 110.

I'm like, wow, this is like prediabetes. If you talk to your doctor about it, he's like, well, yeah. But he says, you know, come back when it's higher and I'll give you some medication. So I think how it's felt like different than that. Listen, at the end of the day, it is possible to answer two questions. Is there anything going on inside your body that you need to know about it? And the second question is, what are you likely to come down with? What's likely to cause you medical problems down the line?

And what can you do to slow it down or prevent it? And that's fundamentally the diagnostic side of Fountain Life. And then there's the therapeutic side. So here's what happened. You come through Fountain Life. We have centers in New York, Orlando, Naples, Dallas, Texas. We're opening up in LA next year. We have 40 centers that were planned around the world. And you come in for a day, typically an overnight stay. You can do it in a day, but we recommend overnight. And we're going to digitize you. We're going to do a full body MRI, a brain MRI, brain vasculature, brain blood flow, a coronary CT with an AI overlay, not looking for calcified plaque, but soft plaque. If it's calcified and it's in the walls of the artery and it's not blocking your

coronaries, you're fine. If it's soft plaque that can like just break off in a pulse, right? If it's calcified, it's like cemented there in place. It's the soft plaque in the walls that can evolve, that can block a coronary artery and then, you know, you're dead. We do DEXA scan. We do your full genomics, metabolomics, your microbiome, retinal scans, strength and balance, all of those things, 150 gigabytes of data. It's the most exhaustive upload we got provided. All that data gets uploaded. There's AI overlays on everything. And then there is a convergence of the data to provide a return and a review of those results to understand, again, those two questions, what's going on inside your body that you need to know about and what's likely to happen. So here's the data.

The first 5,000 members going through it, 2% of people have a cancer they don't know about, which blows me away, right? Two and a half percent have an aneurysm they don't know about. And then 14.4% have either cardiovascular, neurodegenerative, or metabolic disease, or the aneurysm or cancer. And so that's a significant number of people. And, you know, I've had in the last month, two friends who've gone through Fountain Life, and we've discovered and we've saved their lives. And we had hundreds of people. One of my friends who we're doing business with, he's a massive hotel developer. He was coming through because we're starting to work together. We discovered two, not one, two aneurysms in his head that were just paper thin.

He was in surgery a few days later and now he's out. The doctor said, you caught it just in time. And these were significant aneurysms. Another friend of mine, 50% occlusions in his LAD and his coronary. And so we've saved hundreds of lives. And I think at the end of the day, if you're able to afford this and it's not cheap, right? We have a 12K offering, a 20K offering. It is the cheapest money you will spend. And it's a chance for you to actually feel confidence like I'm actually okay. Every year I go through this. I go through an upload every single day. It's a lifelong, long life membership, so to speak. At the end of the day, I am anxious until I go through my upload and then I feel relief. I will find something someday, but I'm going to find it at the very beginning. When's the best time to catch a fire? At the start, at ignition. When's the best time to catch a fire you know at the start at ignition when's the best time to find cancer you know at stage one um and so that's yeah and you also do liquid biopsies too not just the imaging right so we do liquid biopsies we do

120 blood biomarkers we do you know it's it is the most exhausted i mean you know uh dr helen messier uh she like you is a functional medicine doctor. I recommended her to you guys. I know you did. And thank you. I knew her from years back from HLI, but she's now our chief medical and chief scientific officer, and she's amazing. And it's the most exhaustive functional medicine upload possible. And that's half. The other half of the business is therapeutics. It's like, you're on our medical advisory board. Thank you. Along with a number of other incredible individuals. And our mission is what is a therapeutic out there that is safe enough, but has outsized potential gains. And then we make that available to our members, right? So

like therapeutic plasma exchange uh we can talk about that or access to rapamycin or natural killer cells or stem cells yeah yeah let's talk about that because i think you know that's the other thing you talk about in your guide which is really great so function health if you can't afford it what do you like what do you do is there is there a way to kind of get around it or how do you so i mean so first of all uh you can go to fountainlife.com peter and um and you can get the information about it uh we will have a a digital lower end digital membership but the imaging is really important um and you know we we have stood up an insurance company, a health benefits company for on the insurance side where self-insured companies can can buy this for their member for their employees. And then if the blood test gets to a particular point and triggers the need for a CT or an MRI so that it's an escalating level of testing. But the problem is, you know, most health insurance pays you after you're sick, after you had the problem.

And that's the problem. You know, it's not preventative at all. It is basically, you know, I hate this. Fire insurance pays you after your house burns down. Life insurance pays your next of kin after you're dead. Health insurance pays you after you're sick. Right. It's crazy.

Some of these other technologies and techniques are things that are on the margin, but that are interesting and that you're doing and that you outline in your wonderful manual. And there are things that are around managing the risk factors, whether it's prescription medications for managing cholesterol, whether it's off-label uses of medications and things like rapamycin and peptides. Can you kind of walk us through what you're doing? And remember, buddy, this is personalized for Peter. This is Peter's map based on Peter's biology, his tests, his own things. I put that as a disclosure in the book and also in my PDF that everybody can download for free at dmhandus.com backslash longevity.

It's a 30-page summary. The book is a summary of books out there. The PDF is a summary of the book itself. It's a summary of a summary, which is available for free for anybody. You need to have the data. You know, you can read all you want. If you've got a physician, go over it with them. I'm much more of an experimentalist.

You know, Tony Robbins, who's a co-founder of Fountain along with me, same thing. And in Lifeforce, we talk about a lot of the experimental elements we're doing. So this is what's going on right now. We've just stood up therapeutic plasma exchange at Fountain. And this is, you're familiar, you've done it. Dr. Many times. Dr. Yeah. And it's basically getting an oil change for your body. It's basically in one arm come as a intravenous pulling blood out. It goes through basically a separation and filtration system. It separates out your red blood cells, your white blood cells. And

then the remainder, the plasma, which is mostly albumin or saline, gets thrown away and replaced with fresh oil, fresh albumin and saline, mixed back in with your cells and put back in your body. And you accumulate waste products in your bloodstream. And this is a mechanism for getting rid of that one of the things that were uh that were standing up under an FDA ind protocol which I'm excited about it's not it's not ready yet it will be available in the first quarter we're doing it with cellularity is um uh the first thing we do is we give the individual a deep tissue massage. And that deep tissue massage liberates stem cells, it triples number of stem cells in the peripheral blood system. So we then do the TPE, the therapy to

plasma exchange, and we separate out the stem cells for banking purposes. And then when we give you back your albumin and saline, we are going to be introducing umbilical cord plasma. So we've all heard about young blood. This is the youngest possible growth factors. Turns out cellularity is the largest storage facility for placentas on the planet, both cord blood and also cell products and tissue products from placentas. And it's got a large supply of umbilical cord blood. So this will be under study. And it's for those people who want to be part of experimental protocols. And there are people out there who want it, like me, maybe you. Exactly. Yeah, I think I've done it. you know it's going to come down in price like everything else i think you know but there's there's other things you can do that are you

know really helpful that you're doing that that um um you know may may be cheaper for example i'd love to know your thoughts on rapamycin and the peptides you're using because you talk about those like yeah so your regimen i'm on a i'm on a rapamycin protocol uh probably the same it's it's a function of your body weight for me um it's six milligrams uh once a week and it's uh you know basically three months on and a month off um are you on rapamycin now yeah i've started based started it based on the literature and looking at it. I think it's one of the most promising molecules out there from a pharmaceutical perspective. And it's basically derived from Rapa Nui from the dirt. And it was a molecule they found in there that was on Easter Island. It turned out to have a lot of benefits in modulating not only immunity,

but also mTOR, which is one of the key regulators of autophagy. So it's sort of a way of mimicking fasting, right? So instead of fasting, you can take mTOR and it seems to have effect, which is really remarkable because even at later dates in your life, when you start it, it seems to have an effect. Like when you're in your 60s. Yeah. Like if you don't start exercising until you're 60, it's probably not a great thing. But if you start this even when you're 60, it actually can work and even extend life in animal models so there's not enough human trials yet but it's something that's used as a fda approved drug for other indications i agree with you that it's one of the most promising and most um uh meaningful longevity meds out there. I mean, a lot of stuff is hearsay, but this has the strongest body of evidence. And there are studies that have either been funded or will soon be

funded to actually demonstrate the efficacy in humans. Yeah, that's what I'm excited about. So before that, we're kind of guinea pigs, but we're very cute guinea pigs. Yeah, I mean, one of the things I'm excited about that Fountain is doing is it's got a massive Before that, we're kind of guinea pigs, but we're very cute guinea pigs. Yeah. I mean, one of the things I'm excited about that Fountain is doing is it's got a massive amount of data. So we know every single member who's on rapamycin and we're uploading every member every year. So we have a vast amount of data on these individuals. So we're effectively doing large-scale studies

with the members' permission, and we'll publish results as we get them. Yeah. So I think tracking the data is important. That's one of the things I love about Fountain Life is that you have rigorous science behind it. You're looking at not just doing stuff, but tracking the outcomes on your patients, which matters. And I think, you know, in a way, this is how we learn. Yes, you know, it's very expensive and it's not available to everyone, but it's giving us insights into what will be effective. And the prices will come down. You know, the price will come down.

I mean, that's the case in technology stuff is when in the beginning, when it doesn't work perfectly, it's expensive. And then as, you know, as it starts to work better and better, the price comes down and becomes available to everybody. Yeah, like a full-body MRI would have been $10,000, $20,000 years ago. Now it's $2,500. It's probably coming down to $300,000, $400,000. Your whole genome sequence you could have done for, was it $100 million? Well, let's see.

When the U.S. government did it for $3 billion, Craig Venture did it for $100 million. And it's been dropping at five times more as law and you know depending on on who you talk to it's 200 to 500 dollars which is crazy seven hours yeah yeah anyway so 500 bucks from three billion that's pretty good so i think we'll get there for everybody but this is how medicine and science works what about uh cognitive enhancement you're talking about nootropics and modafinil f farnivir, talk to me about that. So I was going to ask you about that as well. But so listen, am I interviewing you? Are you interviewing me? Listen, so it's interesting, right? I think about this cognitive at the end of the day, people want a few things. They want to be sharp. They want to move well. They want to look good

and cognitive enhancement. So it's interesting. A study done years ago looked at hundreds of molecules to determine what actually increased college students' performance on exams. And they found two molecules in particular. I know you know what they are it was sugar glucose and caffeine yeah coffee and sugar yeah basically coca-cola you know no dose anyway um for me uh the one particular drug i will use especially if i'm hopping off a uh a jet and need to go on stage and be sharp is modafinil provigil. And, you know, you should look it up. It has had zero side effects for me. And I've, I've spoken to a slew of neurologists on it and it, you know, it will list a number of, of potential downsides, but it, it is a, when I use provigil or modafinil, I feel like all of a sudden, if I had four cylinders firing, all of a sudden it's eight cylinders firing.

It's the closest thing to – what was that movie? You took a pill and all of a sudden your intelligence increased multifold. I don't know, but I want that pill. Yeah, so you're right. I think the compounds out there like drugs, people take Adderall or Speed or other things. I don't like Adderall for the other side effects. And modafinil was actually developed for fighter pilots to be awake for long periods of time.

You just don't want to, if you use it, you don't want to take alcohol along with it. Yeah. And you probably don't want to take it late in the day. So it can be very effective, but there are other substances that are nootropic, which basically means an enhancing cognitive performance, right? Noo means brain and tropic means growth. So there are things like lion's mane and even things like fish oil or choline or vitamin D, other compounds that you can actually take as supplements. It can be quite effective.

I would do them all. Yeah, I think they're important. But it's interesting, right? Because a lot of these drugs that we, these medicine supplements we take, we're taking them out of faith because some study said something. But I'll tell you, the question is, do you have a visceral benefit? Do you actually feel? So caffeine is do you have a visceral benefit do you actually feel so caffeine you'll feel a visceral you know nicotine is a neurotropic as well um uh for sure uh not one i

want to engage in but it truly is well people are taking nicotine you know things in their cheek or their nicotine sprays not only from smoking so i i had a friend who gave me that once i was like wow a little much for me yeah a little much for me but uh what about uh your peptide regimen because peptides are things that people don't understand but they're essentially these small mini proteins that are used to regulate information signaling through the body and they're regulating almost everything there's thousands and thousands of them not exactly like hormones but they're like yeah kind of the same concept they're they're little tiny proteins that are messenger molecules that regulate every biological function and and they're they've gotten increasing use over the last five years increasing

fda scrutiny at the same time although fda tends to want to shut down anything that works it's not a drug like ozempic is a peptide and they're like like, Oh my God, Ozempic, what a gravy train. Let's, let's lock this all stuff up so nobody else can use it and, and charge 10 times what it actually costs. Let me ask you before we jump into the peptides I have in my, my longevity practices. Let's talk about GLP-1 drugs and Ozempic because the evidence is coming out that it looks like it is also a longevity uh medicine really well what are you learning about that because i haven't seen that i've seen a lot of other things that concern me a lot but i'd like to hear your perspective just i guess the it's triggering reduced appetite and reduced caloric intake.

Yeah. Which over, you know, it's interesting. When you look at what extends life in humans, there are a few things. You can become a eunuch. Not happening. Not happening. You can minimize your caloric intake down to like a bare minimum right not 1200 calories per day next yeah uh and then you can exercise you can eat whole

plants and get rid of sugar and all those other things right down and so and so caloric reduction um is one of the things that causes enhanced health span. You may not enjoy it, those of us who enjoy an enjoyable meal. So I think ozempic's having a longevity impact, increased health impact because of its caloric, its reduction. People just don't eat because they get nauseous. Yeah. I mean, I think that's interesting. I don't think it works mechanistically like

rapamycin, which inhibits mTOR, which induces the same phenomena of caloric restriction. In other words, mTOR is shut down when you're starving and you can mimic starvation by taking this drug rapamycin. And if you take it properly, and I think the way it's being studied, it's going to be very effective. It's very different than, say, taking a drug that makes you nauseous and not want to eat and lowering your appetite. So there was a great study, Peter, where they took people who were obese, and they were very obese and diabetic. And one group got a gastric bypass, and the other group, the control group, got the same diet

that people who had a gastric bypass had to eat after they had a bypass, right? There was no difference in the outcome. Oh my God. Exactly the same result. And I had a friend of mine die during a gastric bypass. It's a dangerous surgery, especially when you're morbidly obese. But the point of that is it's not the surgery. It wasn't the drug. I think it's just the not eating the bad food. Now, I do think that

I'm concerned about Ozempic for other reasons. One, it seems to have a dramatic increase in pancreatitis, in small bowel obstruction, and things that are quite serious. So normally when we see an increase in a phenomenon in medicine, we say, oh, my God, eating processed meat increases your risk of colon cancer by 20%. That means your risk goes up from 5% to 6%, a 20% relative increase. They use marketing lingo. Okay. But that's a big result. But what we're seeing with Ozempic is not a 20%, but like a 900% increase in pancreatitis, like a 450% increase in small bowel obstruction. And the longer you take it, the worse it is.

So I think there's some challenges also with muscle loss and weight muscle, muscle wasting. I agree. We've seen and found those on Ozempic, we've seen a reduction in significant, the weight loss comes more from muscle than other parts, which is a problem. Yeah. And there may be ways to mitigate that by rigorous strength training and lots of protein. But I just, I don't think it's an easy fix. And, you know, I literally, I just had a patient email me the other day. He said, I just lost 200 pounds following your program. Like it, you know, you don't need to, to go to Osempic. Now there's other issues with brain regulation. And I think I'm working on a whole sort of, uh, sort of series of articles around how our brain has been hijacked by food

and, and have the addictive properties of food. So by the way, can we put like warning labels on the side of most consumer foods? Working on a pizza. I'm a non-profit. I'm working on it. Oh, my God. I mean, it's like the crap that kids eat and that's passed off as nutritional food. I mean, cereals, it's criminal.

It is fundamentally criminal. Yeah, it is. When you go to Europe, you got the cigarette packs and it says, this will kill you. You can barely see the brand on it. It literally says, this will kill you. But it should be like that. Other stuff we're eating here. Cheerios or the Apple Jacks or whatever. It's sugar on sugar. On the peptides, I'll just mention real quick. A peptide I love is in the skin cream I use. It's called One Skin. It's a 10 amino acid peptide that's a synolytic. So it's killing dead cells in your skin cream i use it's called one skin uh it's a 10 amino acid peptide that's a uh a senolytic so you know it's killing uh dead cells in your skin um and then you know uh others i list

them in detail cgc 1295 which is for for muscle and bpc 157 for reduced inflammation so forth i won't go into it it's in if you again if go to dmantis.com backslash longevity, you get a free download, 30 pages of all of this. Let me mention for your viewing audience, if I could, something that I'm very proud of that we did last week. Yeah. And I was in Riyadh with a group of longevity scientists announcing the largest prize ever in human history. And so this is called XPRIZE HealthSpan.

It's $101 million prize. And it's actually I raised $141 million. I'm a significant contributor to this. It's my largest contribution ever made. $40 million came from Evolution, which is now a foundation in Riyadh in Boston. It's the largest funder of age and health-related research on the planet. And then a quarter of the prize came from Chip Wilson, the founder of Lululemon. Oh, yeah.

He has a muscular dystrophy called FSHD. And in addition to the $101 million, we put a $10 million bonus prize on FSHD. So to win this prize, all you have to do is reverse functional loss in muscle, immune, and cognition by a minimum of 10 years, a goal of 20 years. So this is a request for teams around the world to run massively parallel experiments. So far, after one week, we have 80 teams registered. I think we'll get to north of 500 teams around the world in this competition. And we're going to be teams have to recruit their own subjects. They'll probably be cohort sizes of 50 to 200 people.

When they're ready, if they're a serious team, we send our judges there to measure the cohort. We measure their muscular strength, their cognitive ability, their immune function. Functionally, in other words, I don't care what your clock says. I care how functionally. Can you climb those stairs? Can you remember these numbers? Can you mount an immune reaction to a influenza vaccine? And you get to treat that subject group for up to a year. You can treat them for a day, six months, or up to a year.

And at the end of that, we're going to measure function again. And did we bring you back in time at least 10 years? My goal is 20 or more years. And, you know, the competition is going to run for seven years. And so if you want it's going to competition is going to run for seven years. And so if you want more information, anybody listening wants to put a team together, if you go to XPRIZE.org slash healthspan, it's X-P-R-I-Z-E.org slash healthspan. And you can register for a team. I've had friends of mine like, oh my God, this is amazing. I'm going to register. I'm excited to see what comes out of this competition. I mean, that's so important, Peter, because what I want to point out about this is so unique is that most of medicine and most of medical science has been focused on the study

of diseases, not on the study of health. And it's a fundamental frame shift that's going to change everything. If we can really reframe our conception of the body from focusing on just diseases and their origins and their treatments to understanding the biology of health and the laws of nature that govern the biology of health, it's going to revolutionize everything in medicine. And I think it's just one of those cataclysmic events. If we can actually do what you're saying we can do, and I believe it's going to happen, I think it's going to change everybody's mindset. And for functional medicine, what I do is essentially what that is. It's a science of health, of understanding how to study health, create health, understand

deviations from health. It's not about treating diseases. I never treat disease. I look at what's going on in the body and where it's out of balance and then tweak it and tune it up. I literally just did a podcast or interview with a guy who's going to be skiing solo to break the world record to go from the coast of Antarctica to the South Pole, carrying a 500-pound sled by himself, unsupported. Okay. Now okay now we did testing he's 39 years old he's incredibly fed he's already climbed every i thought you'd tell me he's 95 years old

no no he's climbed every peak on every continent at the highest peak he's rode his boat across the drake passage to antarctica wow he's he's crazy and i'm like this guy's gonna be healthy i'm not gonna find a single thing but i found he had a number of things that were really fascinating and significant that nobody really knew that were not diseases, but he had methylation issues. So he wasn't able to properly detoxify. And he wasn't able to, you know, when he put his body under stress and did a thousand mile bike ride, his liver conked out. His B vitamins were low.

His vitamin D was low, his iron was low. And I'm like, wow, this is really interesting. So he had a whole bunch of different things that weren't diseases, but they were just things that weren't optimally tuned. And so I think by giving him a program to optimize his health, which is really what you're talking about with this XPRIZE and the moonshot for the health span, is really getting people to think about this problem, to look at this problem, to solve this problem, which has never really been done before. There's no, I mean, it's a joke.

We have the National Institute of Health. It's not. It's the National Institutes of Diseases, really. It's not anything to do with health. Yeah, you treat a disease at a time. You treat an organ at a time. And the origin of this competition is a few different things, conversations with Aubrey de Grey and with Sergey Young and George Church. And, you know, I've spoken to you about this and gotten your advice on this competition over the last four plus years. is that what an individual develops here is something, a therapeutic that actually targets

fundamentals of aging versus just one particular tissue type. And if that's true, if the therapeutic actually is targeting aging, then not only will you improve cognition, muscle, and immune, you'll improve every organ, every in the body and that's that's the objective here at the end of the day can we address aging fundamentally and health fundamentally here so excited about this um you know i hope you and i will talk about this over the uh over the years to come um and uh and follow these teams as they as maybe maybe i'm going to work on it i want to i want to win the 100 million dollars right you're totally able to register for it yeah it's interesting i had i had my you know i'm on the board so uh you know full disclosure there will be a separate set

of judges who judge this and the judges will have no conflicts, nothing. But I had my company, Cellularity, which is up in New Jersey, Bob Haruri, doing natural killer cells and stem cells. And he goes, can I register for this? I said, yeah, I guess I'm going. I'm going to win this thing. I had my team at Vaccinity, which is doing vaccines against neurocog diseases and muscle loss. And he says, can we register for this?

I said, yes. Well, go for it. And so we're going this? And yes, we'll go for it. And so we're going to see a lot of teams, a lot of different approaches. That's amazing. Well, it's so exciting, Peter, what you're doing and you're just sort of tirelessly trying to improve humanity in every aspect. I mean, it's not just through health, but really all your XPRIZE's. If people don't know you, Peter, they should find out about you. They can go to XPRI x prize healthspan i think dot com is that x x prize dot org slash healthspan for information about the competition dmandis.com

slash longevity if you want a free download of the pdf or on amazon longevity your practical playbook um yeah and uh as always pal uh grateful for you uh i love your your heart and your spirit thank you and whenever i go whenever i go to la and visit peter he's like let's have a meeting he's like okay how about we meet at five o'clock on venice beach and we walk for like as fast as we can for two hours and then then that's our meeting. I'm like, okay. You're coming to LA, so call me. Let's do that. Okay. All right, man.

Well, have a great rest of the day. So excited to see this X price come in shape. And your book is just phenomenal. It's just all the nuggets and none of the noise. So everybody get a copy and check it out. And thanks for being on the show, Peter. My pleasure. As always, take care, pal.

Thanks for listening today. If you love this podcast, please share it with your friends and family. Leave a comment on your own best practices on how you upgrade your health and subscribe wherever you get your podcasts. And follow me on all social media channels at Dr. Mark Hyman. And we'll see you next time on The Doctor's Pharmacy. Hey, everybody. It's Dr. Hyman. Thanks for tuning into The Doctor's Pharmacy. Hey everybody, it's Dr. Hyman. Thanks for tuning into The Doctor's Pharmacy. I hope you're loving this podcast. It's one of my favorite things to do and introducing you to all the experts that I know

and I love and that I've learned so much from. And I want to tell you about something else I'm doing, which is called Mark's Picks. It's my weekly newsletter. And in it, I share my favorite stuff from foods to supplements to gadgets to tools to enhance your health. It's all the cool stuff that I use and that my team uses to optimize and enhance our health.

And I'd love you to sign up for the weekly newsletter. I'll only send it to you once a week on Fridays. Nothing else, I promise. And all you do is go to drhyman.com forward slash pics to sign up. That's drhyman.com forward slash pics, P-I-C-K-S, and sign up for the newsletter and I'll share with you my favorite stuff that I use to enhance my health and get healthier and better and live younger, longer. This podcast is separate from my clinical practice at the Ultra Wellness Center, my

work at Cleveland Clinic and Function Health, where I'm the chief medical officer. This podcast represents my opinions and my guests' opinions. Neither myself nor the podcast endorses the views or statements of my guests. This podcast is for educational purposes only. It's not a substitute for professional care by a doctor or other qualified medical professional. This podcast is provided on the understanding that it does not constitute medical or other professional advice or services. If you're looking for help in your journey, seek out a qualified medical practitioner now. If you're looking for a functional medicine practitioner, you can visit ifm.org and search their find a practitioner database. It's important that you have someone in your corner who is trained,

who's a licensed healthcare practitioner and can help you make changes, especially when it comes to your health. Keeping this podcast free is part of my mission to bring practical ways of improving health to the general public. And in keeping with that theme, I'd like to express gratitude to those sponsors that made today's podcast possible.