The Dr. Hyman Show - Why Ultra-Processed Foods Are So Addictive

Episode Date: September 30, 2024

Have you ever wondered why it’s so hard to put down that bag of chips? In this episode, my guests Dr. Shebani Sethi and Calley Means and I break down how ultra-processed foods are contributing to the obesity epidemic, diabetes, heart disease, and even mental health issues. From understanding the science of addiction to decoding food labels, we’ll explore how big food companies are manipulating us—and what we can do to fight back. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman Sign Up for Dr. Hyman’s Weekly Longevity Journal Full-length episodes of these interviews can be found here: Why the Last Thing that Should Ever Eat is Ultra Processed Foods: It Kills 11 Million People a Year How Does Ultra-Processed Food Affect Our Mental Health? Calley Means: The Obesity Crisis, Ozempic, ADHD and Food Industry Lies This episode is brought to you by Rupa Health, FOND, Ketone-IQ, and Happy Egg. Streamline your lab orders with Rupa Health. Access more than 3,500 specialty lab tests and register for a FREE live demo at RupaHealth.com. Get 20% off one-time orders for both new and returning customers. Just visit FondBoneBroth.com and use code MARK20. Save 30% off your first subscription order & receive a free six-pack of Ketone-IQ with ketone.com/MARKHYMAN Shopping for better eggs shouldn’t be confusing. Look for the yellow carton at your local grocery store or visit HappyEgg.com/Farmacy to find Happy Egg near you to get 50% off.

Coming up on this episode of The Doctor's Pharmacy. Certain foods may seem like they're minimally processed. There may be some protein powders that are okay or protein bars from whole food ingredients, canned beans, frozen vegetables. Those are all fine, but be very wary about what you're eating. Even if it comes from Whole Foods or Erewhon

or some great natural food store that you're shopping at, it can still be fraught with all sorts of problems. Attention practitioners. Dr. Casey Means, one of my favorite people and a leading voice in metabolic health, is hosting a free class on metabolic dysfunction and also a six-week training next month. You'll get to ask Dr. Means your questions live, access recorded lectures, and your own blood tests to dive deep into metabolic dysfunction and what it means for both your health and your patient's health. For practitioners who want to master the advanced science protocols, lab testing, and interpretations behind metabolic dysfunction and learn how to

prevent or reverse chronic diseases, this is a great training opportunity. To sign up, go to rupahealth.com slash Casey. That's r-u-p-a-health.com forward slash Casey, C-A-S-E-Y. All this is hosted by Rupa Health, where you can order and manage all your lab tests for free. Sign up at rupahealth.com. That's r-u-p-a-health.com. And if you missed the live session, don't worry, you can catch it later on Rupa Health's YouTube channel. Before we jump into today's episode, I'd like to note that while I wish I could help everyone by my personal practice, there's simply You can catch it later on Rupa Health's YouTube channel. Before we jump into today's episode, I'd like to note that while I wish I could help everyone by my personal practice, there's simply not enough time for me to do this

at this scale. And that's why I've been busy building several passion projects to help you better understand, well, you. If you're looking for data about your biology, check out Function Health for real-time lab insights. If you're in need of deepening your knowledge around your health journey, check out my membership community, Hyman Hive. function health for real-time lab insights. If you're in need of deepening your knowledge around

your health journey, check out my membership community, Hyman Hive. And if you're looking for curated and trusted supplements and health products for your routine, visit my website, Supplement Store, for a summary of my favorite and tested products. Hi, I'm Dr. Mark Hyman, a practicing physician and proponent of systems medicine, a framework to help you understand the why or the root cause of your symptoms. Welcome to The Doctor's Pharmacy. Every week, I bring on interesting guests to discuss the latest topics in the field of functional medicine and do a deep dive on how these topics pertain to your health. In today's episode, I have some interesting discussions with other experts in the field. So let's just

trump right in. Let's talk about what exactly are ultra-processed foods. What are the characteristics? How do we define them? Well, there's something called nova classification. I'll get into a minute, but essentially it's deconstructed food. Basically take raw materials from things like corn, wheat, and soy. You deconstruct them chemically in a lab. You all structurally alter them. So they're not actually the same chemical structure. And our body, remember, gets messages from the outside environment and regulates this biology through chemical signals that depend on the structure and shape of the molecule to create a signal in the body that does good or bad, right? This is really important. So these are funky, weird, Franken molecules. And then they're turned into food-like substances that come in every color, size, and shape of chemically-construed yuck, basically.

Now they're super energy-dense, usually. They're high in calories. They have pretty much no nutritional value, usually. They're high in sugar. I mean, they may have added vitamins. You know, you get your cereal or Froot Loops with added vitamins. Well, that's not exactly a health food. They are high in sugar.

They come from all different sources. High fructose corn syrup, dextrose, maltodextrin, cane sugar, fructose. There's a million different names of sugar. You can Google it and see. We'll put a link to all the different kinds of names of sugar, but they hide the names of sugar on the label so you get confused. It doesn't just say sugar. It's also high in refined grains.

So these are highly pulverized grains, mostly wheat, that are chemically altered and are not resembling their original form. And they're maybe from corn, from wheat, from beans like soy. Also high in unhealthy fats, usually trans fats still on the market, refined oils and so forth. They contain often excess salt. They're hyper palatable. They're easy to overeat. They're low in fiber, typically low in protein. They're low in vitamins and low in minerals. So all the things you need to thrive, they don't have. They also tend to spike your blood sugar a lot. They also don't make you feel full. So people who eat ultra processed food eat

500 calories more a day. This was a controlled study at the NIH with Kevin Hall. Really impressive data. So basically, people who were allowed to eat whole food versus ultra-processed food as much as they wanted, the ones who ate the ultra-processed food ate 500 calories more a day, 3,500 calories a week. That's a pound a week. If you keep doing that all year, that's 52 pounds of weight gain in a year. So what are the examples of ultra-processed food? Well, it's potato chips, crackers, pretzels, candy, microwave popcorn.

Don't ever eat that. Muffins, donuts, sandwich breads, cookies, flavored yogurts, puddings, jello, breakfast cereal, granola bars, things with added sugar, food dyes, natural, artificial flavors, colors, preservatives, gums, emulsifiers. Oh, my. Right? It's a lot of stuff. So don't eat that. It's not food. Ready-to-eat meals, instant noodles and soups, frozen TV dinners, canned ravioli, pastas, packaged meal kits, nasty. Unless they're made from whole food. Processed meat and

dairy. Again, we eat a lot of this stuff. Hot dogs, deli meats, fish sticks, which I don't even know what they are. Often they're not fish. Chicken nuggets. Most chicken nuggets have like 35 ingredients, only one of which is chicken. Processed cheese slices. They're not even allowed to be called cheese because it's not actually cheese. they're not 51% cheese, various spreads, flavored milks, non-dairy beverages, coffee creamers, various protein shakes you have to be careful of, like isolated soap proteins, deconstructed soy, potentially very cancerous, so be careful of that flavor. So it says soy, a soy shake, and that's like maybe really bad for you. Flavors, sweetened nut milks often can be problematic, you have to watch what's in them. And of course, sugar, sweetened beverages, soft drinks, lemonade, iced tea, soda, fruit drinks,

punches, energy drinks, flavored coffees, all this stuff is just nasty. So you want to stay away from that. When it comes to a healthy diet, we hear a lot of these terms, ultra processed food, processed foods. Most people have no clue what they are. And I think it takes a little bit of education to understand how to navigate this landscape of processed and ultra processed food. Now, what does it mean? We're going to talk about the difference between ultra-processed food and other types of processed food. For example, Doritos versus a can of sardines, they're both processed, but highly different in their effect on your biology. You know, is one worse than the other? How do we tell the difference? We're going to get into all of that. Part of the problem today is

that most people need a PhD to understand nutrition labels. And many of us fall into the trap of convenience and just sort of get whatever seems good or whatever package looks like it's going to be healthy and basically there's a health claim on the label you think it's good for us but that's basically one of my rules of eating if it has a health claim it's not good for you in other words gluten-free potato chips or a sugar free this when it says that it's always something bad that's added so these are made by big food in order to lure you in and get you sucked in and trapped. As a result of that, we have a nation and a world increasingly where more than half the calories come from this hyper palatable,

easy to overeat, ultra processed food like substance. And you have to look at the definition of food. Food is something that supports growth and life. The truth is these don't. So by definition, they are not food. Just look it up in the dictionary. If you can convince me that these things are food, well, good luck because they're not. And they don't meet any definition of what food should be like. And it essentially is a substance that helps support life and growth and ultra processed foods do neither. In fact, they do the opposite. Now I'm not just making this stuff up. There's an amazing study. Now it's a, it's an observational study, butational study but it's a very well done study recently published just news just out in the british medical journal they looked at 45 different pooled meta-analysis

involving 10 million people the hook here is that these were studies that were not funded by ultra processed food companies you know we might have heard me talking the other day about artificial sweeteners and how the large studies showed study that showed artificial sweeteners are not harmful at all. But when you look at the funders of the study, it was the American Beverage Association, formerly known, my friends, as the American Soda Pop Association. Clearly, we need to look at data that is not corrupt. And when you look at studies that are funded by the food industry, it's 8 to 50 times more likely to show a positive impact for their food product, whether it's dairy or artificial sweeteners or whatever. And when they looked at the data from this large pooled meta-analyses, I looked at people who ate higher amounts of ultra-processed food.

There was a 50% increase in the risk of cardiovascular death. It was a 48 to 53% increased risk of anxiety and other mental health disorders like depression. Now think about that. The risk of having heart disease and a heart attack and mental illness are the same from eating ultra processed foods. We get that these foods can cause obesity and diabetes and heart disease, but mental health crisis is also driven by these ultra processed foods. We did a whole episode on this. I think it's really important to go back and listen to it. We'll link to it in the show notes. There's also a higher risk of type two diabetes and many, many other conditions. They go through many conditions, autoimmune disease, inflammatory disorders.

The evidence also showed that there was a link between ultra-processed food and a greater risk of death from any cause, and a 40% to 66% higher risk of heart disease-related deaths, obesity, type 2 diabetes, sleep problems, and a 22% increase in depression. We're seeing this mental health crisis, obesity crisis, diabetes crisis, heart disease crisis, autoimmune crisis. I mean, the list goes on. Chronic disease is the number one driver of our healthcare expenditures. It's the number one driver of death globally. Why is this happening? We never had these problems.

You know, I saw something on Instagram the other day. There was a video from 1930s film, and there was not one person who was overweight in the entire video of people walking down New York. Big change from then to now. And this has led to the epidemic of chronic disease that's driven by this ultra-processed food. We're going to get into it. We're going to go deep in this topic and we're going to learn about how we begin to determine what is ultra-processed food, what we should avoid. And hopefully maybe we'll live in a day when food labels are clear. I'm working on that in Washington with my Food Fix campaign on clear labeling and child-friendly labeling. Let's get started with a case example of what an ultra-processed diet can do to our bodies in as little as two weeks. You think, oh,

this takes years and years to develop problems. Well, not really, my friends. You see the results very quickly. Now, Tim Spector and a scientist from King's College in London performed a short-term study on a 24-year-old set of healthy twin girls. This is a different twin study than the vegan twin study. Now, one twin was assigned to eat an ultra processed diet when you included a typical breakfast, a pancake syrup or cereal with a blueberry muffin. Pretty much our average diet. Lunch was a peanut butter and jelly sandwich on white bread with chocolate milk and chips and dinner was either a cheeseburger and fries or a meatball sub with cheese crackers and a diet coke. The other twin ate a minimally processed whole foods diet. Now each diet, this is really important, each diet was controlled for calories.

So they ate exactly the same amount of calories. I'm going to say that again. They ate exactly the same amount of calories. They also had the same amount of fat, same amount of sugar, and fiber. But the difference was the processing of the food. Now, we're going to get into what this means in a minute. What was striking about the study, after just two weeks, that the twins eating the ultra-processed diet had higher blood cholesterol and lipids,

higher blood sugar, they gained more weight. Now remember they had the same amount of calories, friends. So it's not all about the calories. It's what the calories do to your biochemistry, your hormones, to your immune system, to your inflammation, your gut microbiome. It's not just calories in, calories out. It's more complex than that. Also, the studies show, they look at the microbiome, had a really negative effect on the gut microbiome. Now, we know that if you swap out in animals a healthy microbiome for a microbiome, for example, an obese mouse, that the other mouse eating the same amount of food will gain weight. So we know that it's not all about calories, how they're processed, how they're metabolized

and so forth. Now, none of these changes, these adverse changes that were in the twin eating the ultra-processed diet were seen in the twin eating the whole food diet. She actually lost weight. So one twin, again, eating the same amount of calories gained weight on ultra-processed food. The other twin lost weight. Just register that for a minute. Now, the results aren't published yet. Hopefully, they will be. Again and again, I see my practice over and over again, how ultra-processed foods wreak havoc on our health, and they do it very fast. The good news is you can reverse it very quickly too, right? So eating real health foods can reverse these effects.

That's what I did with my 10-day detox diet. And we saw amazing results in thousands of patients. I often talk about this one patient I had in three days was off insulin. Simply after 10 years of diabetes on insulin, three days of eating this way completely eliminated her need for insulin. Now, how did this happen? How did this become 60% of our diet, 67% of kids' diet? Globally, it's increasing everywhere. Well, the industrial revolution spawned a whole bunch of advancements in food processing technologies and the mass production of canned goods and refined grains.

And it seemed to be a boon to humanity. And it did help a lot. We got to preserve food. We got to store it longer. We got to be able to feed people who couldn't be fed. We have hunger. So it wasn't all bad. In World War I and II, there was a huge catalyst for ultra-processed food production because there was a huge demand for non-perishable foods shipped to soldiers overseas. And so it needed to be something that was stable, that could be sent to the battlefield, that wouldn't rot. One of the basic rules of healthy eating is only eat food that rots. I don't know if you saw, it was something I saw once. I don't know if it was a movie or something, but some guy had forgotten like a Big Mac

in his pocket for years and it was fine. It hadn't degraded. It hadn't decomposed. It hadn't gone moldy. It was just fine. Now, if you want to eat food that rots, that's a good concept. So after World War II, the economic growth and lifestyle changes that happened, women entering the workforce, there was an increased demand for convenience foods, fast

food, TV dinners. There was a gathering of all the fast food and processed food makers in the late 50s, as I recall. This was written about in Salt, Sugar, and Fat by Michael Moss. We had, he was my first podcast guest, actually. And in that meeting, all these companies were were like we have to fight this trend towards eating real food which there was another sort of group of people promoting that they decided to make convenience king and so they created a culture of convenience they disintermediated people from the kitchen they

invited betty crocker to get recipes of junk food in the house so you apply your ritz crackers on top of your broccoli casserole or the alelveeta cheese or your can of cream of mushroom soup from Campbell's all in your recipe. So it was a lot of processed food in the recipes. And there was no Betty Crocker. She was a made up person. I thought she was real because my mom had the cookbook. But anyway, in the 80s and 90s, the food companies began engineering foods even more. And they were engineering foods at an accelerated pace using all sorts of technologies that allowed them to add additives, preservatives, emulsifiers, which are terribly damaging for your gut and microbiome. There's like 600,000 of these products now on the market and starch, sugar, refined grains, and processed oils became ubiquitous in supermarkets, vending

machines, fast food outlets, and are basically what we call the SAD or the sad diet, the standard American diet. Now, as I said, it's 60% of diet here, 67% of kids diets. It's more than half the energy in high-income countries, even like Canada, the UK, Australia. It's nasty. The studies are clear on this. By the way, we're linking to all the studies. Everything I'm saying is evidence-based, is backed by references. You can just go to the show notes, you'll see them all. So studies show that the more ultra-processed foods that make up your diet, the less nutritious their diet quality tends to be overall and the greater risk they are of developing chronic inflammatory diseases heart disease obesity diabetes cancer

high blood pressure stroke dementia autoimmune diseases depression i mean the list goes on and on and according to cdc more than 70 percent of deaths or 1.7 million deaths a year in the US are caused by chronic diseases, mostly caused by our processed food diet. This is a kicker. I've mentioned this before, but for every 10% of your diet that comes from ultra processed food, the risk of death goes up by 14%. This is from the Global Burden Disease Study. We'll talk about that in a minute. And that's enormous. So if you think of 60%, right? So it's six times 14. It's a big number.

It increases your risk of death, not just getting a disease. Now, what's really scary is that the government is funding this. They're funding the subsidies that go into the agriculture, that produces the commodity crops that are turned into ultra-processed food, benefiting from the incredible food stamp program, which is great, except that 75% of the SNAP benefits are used for ultra processed food and 10% are used for soda. It's about 10 billion a year.

We're working on trying to change this in Washington and we have a bill now in to prevent ultra processed food from being purchased with SNAP dollars if you're a kid, because we know these are deadly for kids. The data is so clear. Now what's the difference between ultra processed food and just regular processed food? I read an article in a nutrition journal years ago about defending processed food as being something

as old as as humans we've been you know drying food and preserving food and fermenting food and curing food for a long time so what's the big deal about processed food if you look at the funders of it if you look at the journal it's just funded by the food industry it's so corrupt my friends it's so corrupt i wrote about that i think in my book, Food Fix, or one of my other books. But it's a pretty frightening thing. Unless you just pick an apple from a tree and eat it, or just eat a raw egg, most food is processed to some degree. Cooking is a form of processing, right?

It's not really that processing is bad. It's what is the processing? So minimally processed foods are fine. We've been doing it for thousands of years. Olive oil is processed food. Yogurt, but hopefully from A2 cows or goat or sheep that are generally raised. Cheese is a processed food. Canning food, so sardines, canned tomatoes.

Fermented foods, sauerkraut, miso. Frozen foods, beef, jerky, dried foods. Basically, those are all processed foods, but they're fine if you can recognize the ingredients, if you know where they are, if you can see the number of steps it took to get from farm to your fork, it's okay. If it doesn't have a list of weird franken ingredients, that's okay. It depends on how they're processed. Certain foods may seem like they're minimally processed, or maybe some protein powders that are okay, or protein bars from whole ingredients, canned beans, frozen vegetables. Those are all fine, but be very wary about what you're eating. Even if it comes from Whole Foods or Erewhon or some great natural food store that you're shopping at, it can still be fraught with all sorts of problems.

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that looks and tastes incredible. Their farming standards, coupled with the humane treatment of their hens, lead to superior tasting eggs. So choose Happy with Happy Egg. Visit happyegg.com slash pharmacy to get 50% off your next dozen and look for the yellow carton at a store near you. That's happyegg, H-A-P-P-Y-E-G-G.com slash pharmacy, F-A-R-M-A-C-Y. So the rates of obesity and binge eating and addictive-like eating are rising alongside the increasing dominance of ultra-processed foods in the modern food environment. And there are several mechanisms as to how this works, some which act directly on the brain and some that indirectly act through hormonal signaling.

So our body is very complicated and the brain is connected to the body. And we used to learn in medical school that you have this blood-brain barrier, that nothing can get across it. But that's not – it's like the Berlin Wall. But in reality, it does leak, right? And there are things that do cross. It's more like a coffee filter. You know, it's a sip.

Right. Yeah. So ultra-processed food and sugar decrease our dopamine receptors and make us eat more compulsively. Much like addictive drugs, the highly processed foods, they trigger dopamine reward pathways and they invoke addictive-like behaviors, which have been well documented and include intense cravings, includes feelings of withdrawal when cutting down on ultra-processed food, continuing to eat these things despite knowing the adverse consequences to it, and repeated attempts to try to quit. I'm describing addiction here, basically. And the consumption of larger quantities

over time than intended. People go, it's like emotional eating, it's not really biological true addiction. But what you're saying is it's really a true biological addiction, just like heroin or cocaine or alcohol, that you get withdrawal, you get cravings, you get increased need for more and more of the substance to

receive the same pleasure you down regulate the receptors for pleasure so you have to take more of the stuff to actually stimulate that reward pathway and and it's really this vicious cycle that people get into and then they blame themselves they feel guilty you know for doing it and they think they just have no willpower but you're saying it's much bigger than that. Yeah, that's exactly right. So sugar is an addictive substance. It's not just something we say. It has a straightforward neurochemical basis in the brain, just like any other drug. And I think of sugar as a, it's a recreational food. It's not a food that's essential for survival. We make sugar through the process of gluconeogenesis, through other foods that we consume.

And so it's really about excess carbohydrates. I call sugar a recreational drug. I've never heard anybody say it, but I always write down in my book, sugar is a recreational drug. It's like if you like tequila, it's fine, but not breakfast, lunch, and dinner in the quantities we're having in America. Exactly. Yeah.

And we also, actually, I would like to share a story about this just during the era of COVID since we're in it. Yeah. You know, just to give context as to, you know, why I wrote about this and why I'm working on this as well and continuing to feel, you know, motivated to continue to do my work is the shelter in place order had come, you know, a couple of months back for my county. And I'm in California. I live in Menlo Park. When it was announced, my husband, he's an infectious disease physician at Stanford, and I'm a psychiatrist and a medicine physician, as you mentioned. We both felt doubly invested in this pandemic. We went to our neighborhood Safeway grocery store, and we saw many people loading up their carts with Pop-Tarts, Hawaiian Punch, popcorn, anything ultra processed, basically. And they weren't loading up their

carts with fresh vegetables or, you know, they were out of cookies at the grocery store. Yeah. Toilet paper. And toilet paper, exactly. And there were still, you know, produce left in the store. You know, it wasn't like they ran out of produce. No. So here I was. It wasn't a they ran out of produce. No. So here I was. It wasn't a run on broccoli. No.

Here I was at the checkout counter, and I was thinking to myself, staring at the person's car in front of me that is full of the recreational food, as I mentioned, the food that's not necessary for survival and detrimental to our health. I thought to myself, this is certainly not preparing them for the pandemic or helping their immune system and, if anything, weakening it. And this is our not preparing them for the pandemic or helping their immune system and, if anything, weakening it. And this is our local Safeway. This is the heart of Silicon Valley. So, in this context, it wasn't about affordability or access. That is what motivated me to kind of get that public message out on this topic. Yeah, you did write a great article on The Hill, and I read it, and you really

talked about the way in which the pandemic we're facing is much more serious because of the underlying chronic disease pandemic we have in our society, where it's driven by this ultra-processed food that makes us overweight and sick and causes all these underlying chronic inflammatory issues like diabetes and heart disease and high blood pressure, which are really the same mechanisms. If you look at the mechanisms of high blood pressure, heart disease, and diabetes, it's insulin resistance, it's oxidative stress, it's inflammation, and it's the same thing that's affecting our psychiatric illnesses, which is so fascinating. And most people don't think about using the doorway of food to help treat the brain. And you're doing that in your research

and in your practice. So tell us some of the kinds of things you're doing that in your research and in your practice. So tell us some of the kinds of things you're seeing in your patients using this approach, because it's pretty radical. You're going all the way sometimes to ketogenic diets with these patients with bipolar disease, schizophrenia, depression. It's fascinating. Yes. What I have noticed is that a lot of my patients that come for psychiatric treatment and evaluation, a lot of them have prediabetes and diabetes. And when I look up the statistics on this in our country, 44% of adults today in our country are either preddiabetic or they have diabetes. And I wonder to myself, what is that doing to our brain? We know that affects all these different organ systems, the liver, the pancreas, the heart, but what is that doing to the brain, right? And so I'm happy to talk more about my research and patient care.

But one thing that I felt I didn't completely answer before was kind of how these hormones affect the brain with the addictive piece. And how does it drive inflammation and all that? Yeah. Yeah. Yeah. So kind of going back to that, you know, so I was talking about the definition of addiction. And we know that hormones like insulin and leptin, which is the hormone that tells us we're full, it sends a signal to our brain, and ghrelin that tells us that we're hungry. These hormones modify natural and drug reward pathways in the brain. They have so many effects on the brain. Our hunger hormones go awry and it can actually

increase the reactivity itself of the dopamine system. And so this happens when we consume that excess sugar and the excess carbohydrates in our diet. And they cause these rapid shifts in blood glucose and insulin levels, similar to other addictive substances. So my approach in patient care has been to work on this system to decrease these shifts that occur in our blood sugar and our hormone levels to kind of go back to the homeostatic state that our body and our brains were meant to be in. And so, I treat the metabolic dysfunction and I look at how that improves both metabolic issues as well as psychiatric outcomes. Yeah, so it's fascinating. So you're basically treating the body to fix the brain, right?

You're dealing with these physiologic changes that have to do with our diet and nutritional psychiatry that most psychiatrists aren't thinking about. I mean, most psychiatrists are thinking about, you know, psycho-emotional issues, they're thinking about medication and prescribing antidepressants, but they don't really work as well. And I, you know, I just found that the amount of benefit you get

by addressing these underlying factors is so much greater than you get with medication, which are marginally effective for most people. I think, you know, unless you have really severe depression, but I think the data is just not that exciting about these drugs, right? I mean, they can be helpful for people and they can be lifesaving, but there are also other doorways that you're exploring, which seem to be way more fruitful. Is that your experience? So, you know, the field has come, you know, a long way. There's a lot of research that's been done on the biological piece and neuroscience and looking at, you know, obviously the serotonin hypothesis.

But that's a hypothesis and an observation from like 30 years ago. And all of these research and money has been thrown on developing drugs, but we're not necessarily addressing some of the root causes of why are these chemicals imbalanced. And so that's an important question that I and others are trying to study through research studies and clinical trials. And like you said, we know that although our medications are necessary and lifesaving for many, they have undesirable side effects that can worsen metabolic health. And while it's helping in one domain, it may, in some people, also be hindering improvement in psychiatric symptoms, especially if the metabolic health is poor. So psychiatric treatment is never going to be a one-size-fits-all approach. Mental health conditions are varied.

They're heterogeneous, and they have different phenotypes or presentations. We don't have a single mutation or a gene that we can point to or a lesion. There's no smoking gun. It's a complex relationship of multiple genes and environment. And unfortunately, a metabolic assessment is not part of that routine care. And stigma certainly plays a role in this. Obesity is stigmatized, and so is mental health. Education about nutrition and metabolism is lacking in medical education. Most psychiatrists recognize this relationship. They do?

They understand the connection between food and mood? They're starting to. They understand that there are side effects with psychotropic medications. I think they don't necessarily have the expertise to treat it or address it. They don't know necessarily what to do about it. But most psychiatrists that I speak with, and my department certainly has been very supportive of this idea, and someone has to do the research and someone has to do the work to kind of move the field forward.

And there is a growing body of other researchers working on this. And we hope that evidence-based research has to be done to kind of change the mainstream generative care. Yeah, I mean, you were talking about metabolic psychiatry. I was also noticing that Harvard had a whole department of nutritional psychiatry, which is, you know, seems like bookends on the country. I don't know if the rest of the psychiatric world is thinking about this, but, you know, you mentioned earlier that you work with Bruce Ames, who's an incredible biochemist and nutritional scientist from California, one

of the most published sort of scientists in the world. And I spent a lot of time with him and he talks about this whole idea of a metabolic tune-up and that so many of our biochemical reactions are regulated by vitamins and minerals and that each of us have different needs for different components of those vitamins and minerals. I remember one guy, I was sitting in my office one day working on something. I was thinking I might've been working on that book. And I was talking to somebody about folate and B12 and B6. He said, oh yeah, I had really bad depression and I took some of these B vitamins and I just went away. And I think there are some people who

have a higher need for, for example, folate or B6 or B12 based on these genetic variations that Bruce Ames talks about that really are so prevalent. In fact, one third of our entire genome codes for enzymes, and those enzymes all need helpers, which are vitamins and minerals. And we don't really pay much attention to that. So when I look at depression or psychiatric illness, I see so many different things that are going on there, whether it's insulin resistance and prediabetes or vitamin D deficiency or folate insufficiency or zinc or magnesium, all these various nutrients play a role in brain function. And they're not something we really learn about when we learn about psychiatry, right? Is that changing? I think that is changing. There's a complex relationship between metabolic dysfunction and nutrition, food, mental health. And I want to start off by saying that the idea of food as medicine is not a new concept in the field of nutritional

psychiatry. It's really grown over the past few decades by several prominent psychiatrists and researchers. However, the focus has largely been looking at specific foods or supplements, eliminating certain things from the diet, the microbiome, you know, or looking at the Mediterranean diet, for example, affecting depression symptoms. And these are all very important questions, but what I thought was missing

and why I named our clinic and our group's work metabolic psychiatry is to distinguish that this is a study of how treatment of metabolic dysfunction can affect psychiatric symptoms. There's nothing more disruptive to the healthcare system than a child learning metabolically healthy habits. And what do you have? You have the media that's funded by pharma, not investigating why prediabetes and obesity is skyrocketing among kids, but

actually saying it's anti-science to question a pharmaceutical protocol. They're actually saying it's fringe and anti-science to talk too much about nutrition, to talk too much about meditation, to talk too much about exercise. That's actually refereed as fringe by the media. Well, it's interesting though, because if you look at the guidelines from most professional societies like the American Heart Association, American Diabetes Association, National Heart Lung and Blood Association, the first step of therapy for any of these cardiometabolic diseases, whether it's heart disease, diabetes, high blood pressure, is diet and lifestyle. It's the first thing that's recommended

yet it's not fringe, it's actually part of the essential guidelines. And you know, I want to get into sort of how to fix this in a, but I just want to dive deeper into how corrupt this whole system is that you're really so good at articulating. There was investigative reports that use FOIA, which is Freedom of Information Act, to get emails and direct correspondence from food industry companies like Coca-Cola, for example. And and and they were really so egregious in their behavior and it was so clear that they had a corny strategy. And this review in critical public health called How Food Companies

Influence Evidence and Opinions Straight from the Horse's Mouth. They said the results provide direct evidence that senior leaders in the food industry advocate for a deliberate and coordinated approach influenced scientific evidence and expert opinion. The paper reveals industry strategies to use external organizations, including scientific bodies and medical associations. I think the American College of Cardiology

has 192 million, or the American Heart Association, $192 million in funding from food and pharma a year. They influence scientific bodies, medical associations, as tools to overcome the global scientific and regulatory challenges they face. Challenges of what? Not selling their shitty food. The evidence highlights the deliberate approach used by the food industry to influence public policy and opinion in their favor.

And that is really the crux of this whole thing. public opinion through accordion campaigns, through media, through co-opting the advertising on television and other channels, through lobbying, through these front groups, through corporate social responsibility, the co-op social groups, through co-opting nutrition research, I mean, through co-opting universities and medical experts. How do we battle that? Where do we start? And I want to hear what you're doing, because I think it's really important to look at not just the problem.

I think I've defined the problem well in Food Fix. I think we need to talk about the fix part as opposed to the food. I didn't call the book Food Apocalypse. I called it Food Fix. And I think we're kind of in a food apocalypse. But I think we need to think about the fixing part. Well, let's dive into solutions. I want to be really clear because it's bottoms up and top down.

But I want to be clear. I think we'll dive into some top down. There's a big bottoms up empowerment message here. And my message here from being inside the room with these industries is that it's worse than you think and these people are not smarter than you. They're not impressive. They are rigging the system and we're buying into it. We're still buying into it when there's a Harvard peer-reviewed study. We're still letting these studies convince us that glyphosate, you know, essentially

a neurotoxin that's banned in most of the rest of the world is fine to give to our kids. We're letting them convince us of this. And my message from the bottoms up is trust yourself, is that the system has completely let us down on managing and preventing chronic conditions. And we need to take much more responsibility for our health and our kids' health there. And frankly, listen to the experts, but not give them the benefit of the doubt. And that humans and animals we've domesticated are the only animals that have systematic metabolic dysfunction. Like animals in the wild. Like cats.

There's not... Yeah, there's cats and dogs, but... So there's real obesity in these animals. But there's not many obese wolves. No. The obesity rate among dogs is over 50%. Yeah. By all measures, the depression rate is actually off the charts among dogs. among dogs is over 50%. Yeah. They, by, by all measures,

the depression rate is actually off the charts among dogs. It's like over 50%. There's not a lot of obese, depressed wolves in the wild. There's not obese giraffes. There's not obese tigers, right? Every single animal in the world. I did see some pretty fat hippos when I went to. So technically by their measure, everyone brings that up. Technically they're not obese. They're made to have some extra fat. So you don't, you just, every animal is born, including humans, with an innate sense of what's right for them. And they gravitate to natural food.

They gravitate to sunlight. They gravitate to movement. We, the experts, are beating that out of humans. And we rob our domesticated animals of that. So I really do think there's a spiritual crisis, a bottoms-up situation where we need to get back to understanding where our food comes from and trusting ourselves and giving a little less credence to the experts. But I want to be clear. We need to change the top down. There are trillions of dollars of incentives against the American people. I think we are entering a big year in 2024 where I think people are waking up

and there are specific easy things that we can do. Yeah, I think, you know, I think it's amazing how unaware most policymakers are of these issues. Yeah. So co-opted and like, you know, you were talking before about how, you know, they're influencing policy. Well, it even goes deeper than that. They literally show up in Congress with white papers and research and graphs and charts proving why all their facts, quote, facts are right. And then they, not only

do they suggest policy, they literally write the policy. They write the legislation and they give it to the congressmen and the the legislation and they give it to the congressmen and the senators and have them submit it into bills. And so literally our policies are often being written by the industry. And I was talking to Sam Cass who worked in the Obama administration on food issues with Michelle Obama and he said, you know Mark, you know nobody came from the good guys. Like all we heard was from the food industry with these big briefing books and all this convincing data. And the congressional staff and the members of Congress don't have time to study this and learn about it.

And so they basically just kind of buy it and move forward with it. And so he said, we need to hear from the good guys. And you and I are not from some big lobby organizations with billions and millions of dollars behind us, but we've been actually hitting the street on our own dime, going into meeting with members who are open to meeting with us, actually, and talking about these issues. And I've been sort of shocked at how interested they are, how much they get it once you unpack it for them,

how their light kind of comes on in their eyes. They go, holy cow, we need to do something about this. And then they recognize it from their own lives because, you know, guess what? They're American, too. And if one in six and ten Americans are chronically ill, probably six and ten congressmen or more have chronic illnesses and their families do. And so it's starting to become something we can't ignore. You know, it's not too big to fail, but too big to ignore.

And so let's talk about some of the kinds of policies that might be effective. Now, some things I think I would do if I were king that are going to be challenging to get through legislation. So let's talk about things that are maybe aspirational and things that are really practical that we can be doing. Let's say if we got a new president who was aware of this, and then we're in a political campaign year. So we have a number of people talking about this from the Trump campaign, RFK, whether you believe what he says or not in terms of his overall strategy. Either of those candidates, I'm not proposing for one or the other. What I'm just saying is this is the first time I hear on a presidential campaign some

of these issues being talked about. And I think it's so important. So what are you kind of hearing about this out there on the field? And what do you think would be the sort of first steps that we could take to start to shift these policies? There are six things a new president could do from either party that I think would have 90% support among the American people and could be done in a matter of days and dramatically improve the health of Americans. I think one lie we've been fed is that solutions are complicated to this issue or that things won't change quickly. I don't think Americans are systematically trying

to give themselves diabetes to miss walking their daughter down the aisle, to miss, like my mom did, meeting her grandchildren and dying early. I think Americans want to be healthy and incentives are stacked against us. And if we can change them in a systematic way, Americans are going to get towards the right decision. So there are six things. The first thing, RFK, others have talked about this, but I think it's really important to understand, it's banning pharma ads on TV.

Now, I think there's misunderstanding about why. What about food? Okay. So, let's get... Food is very important. Food companies... It's junk food marketing. Junk food marketing.

Food companies aggressively lobby the Federal Trade Commission to have processed food ads on Nickelodeon. It's the number one ad spender on Nickelodeon. And looking at YouTube kids content, it's all processed food garbage. And we're one of the only countries in the world that allow that type of marketing kids. So food is a big issue. But let me unpack real quick a misconception about pharma ads. So this is the key point here. And this is from working with the pharma companies. Everyone needs to understand this. The point of pharma ads is not to influence consumers. It's to influence the news itself. Yeah.

Okay. So you see these goofy ads with the people dancing and it's like, okay, okay, that does bleed in and that does lead to consumers to want those drugs. The key point about pharmaceutical ads is that they're paying the bills of the news itself. Right. So again, we talked about this at the about pharmaceutical ads is that they're paying the bills of the news itself. So again, we talked about this at the beginning, but we have to get our heads around this. More than 50% of TV news spending comes from pharma. It is an astronomical number.

And it's so simple that if your bills are paid by an industry, you are not going to criticize that industry. You're gonna self-censor. You talk to any politician. The media is supposed to be asking any politician. The media is supposed to be asking tough questions. The media is supposed to be holding institutions to account. I have not seen on mainstream media an examination of what is clearly the largest issue in the world of our

kids being poisoned by toxic food and every chronic disease skyrocketing among children. Is there an examination of the root cause of that? No. The media right now is referees criticizing anyone who even dares to question pharmaceutical solutions, calling them anti-science. The second, you can do this tomorrow, the office- Let's just talk about this, because I think it's important, this thing about the advertising. You know, it's both the advertising of pharmaceuticals and also food. Now the pharmaceutical ads, I think, do, you know, drive what the media puts on the air or not. And I've noticed I've been censored on different shows.

Absolutely. Because of my views. And I remember one time, and this was related to sort of a food thing, where I came up with this idea for the Today Show, which was talk about 100 calorie foods. And this is 100 calorie snack, 100 calorie Oreos, 100 calorie cookies, 100 calorie whatever. And I was like, are they the same? Is 100 calories of blueberries the same as 100 calories of Oreo cookies?

And basically, this is what the food industry was trying to push. And I got through a producer. I don't think it went through the hierarchy of approval. of Oreo cookies. And basically this is what the food industry was trying to push. And I got through a producer, I don't think it went through the hierarchy of approval, and we got on the air and the talent got on and she immediately kind of noticed what was going on. And she tried to deflect and change the conversation and make it about something else.

And then I never got asked back on the same show. And I think, you know, I was on the Martha Stewart show and they were having a show about health and nutrition. And they had a trainer on and the show was supported by the Dairy Council. And they had literally cue cards for her trainer of what the talking points were from the Dairy Council. Now, when you're a talent on television, you don't get cue cards. You don't get a teleprompter.

You have to know your stuff. And so she was literally reading out the Dairy Council. And I said to the producer, why are you doing this? He says, well, this is not factually right. I said, here's all the research to show why this is wrong. And I send him all the research. He says, well, I'm sorry, but we have to do this because of the Dairy Council. And I think you're right.

It controls the narrative. It controls what's on TV. It controls what people are saying. It controls things like what's on 60 Minutes where Fatima, Dr. Fatima, what's her last name? Stanford. Stanford from Harvard was basically saying that all BC is genetic. It's nothing you can do about it.

You have to take these drugs. I mean, and she's now on the Dietary Guidelines Committee, which is very concerning to me. And so I think these are highly disturbing to me. Oh, 100%. No, I just think, and the other issue is the amount of direct targeted marketing at children in the research on that is staggering. It's literally billions and billions of dollars that are spent on targeted ads towards kids, not just through television, but now through social media.

There were, I think, over 5 billion little ads targeted to kids just on Facebook for a games game programs that are embedded in the game program. Yes. And so it's kind of everywhere. It's insidious. It's invisible. And now you can't just say don't watch television because kids are on their screens.

And it's all getting in there. And we don't even know the half of it. So then we've got the food industry having all these, quote, experts on social media touting the benefits of junk food and how artificial sweeteners are good. And they basically pay huge amounts of money to these groups. And it's sort of frightening to me.

Yeah. Yeah. Anahat O'Connor, a reporter at the Washington Post, who's the best food reporter in the country, should win the Pulitzer Prize. He traced the money- He actually helped me with my book, Food Face. He's amazing. I mean, he is incredible.

He's amazing. I mean, he is incredible. He's fearless. And he traced all of these nutritionist influencers on TikTok and Instagram, undisclosed payments from food companies to say that processed food is good and attack anyone, probably attacking you for support people. These folks are attacking you and they're attacking other doctors who are saying, frankly, having the gall to say that we should eat whole natural food. That's literally, there's a coordinated effort paid for by food companies to do that. I was recently speaking to Jillian Michaels, who's a partner with her companies at TruMed,

exercise fitness companies. She was recently, I believe on CNN, and viciously attacked by the anchor for being anti-science for suggesting that Ozempic wasn't the real root cause treatment for obesity. And her saying that exercise, they actually attacked her for being anti-science, for saying that exercise might be a better root cause intervention. Of course, right after that segment was an ad for Ozempic. They're individually the fourth largest advertiser for cable news. Novo Nordic sponsors 60 Minutes that ran that segment unquestionably saying that obesity is a brain disease and genetic and not tied to what we eat or exercise.

From the swamp, from my early days in DC, I know a lot of these folks that work at the large mainstream media stations and they've told privately, it is an absolute moratorium on anything critical of processed food or anything critical or examining why people are actually getting sick. There were not many segments on COVID essentially being a metabolic condition. If you were metabolically healthy, you had an almost 0% chance of dying of COVID no matter what age you were. The best thing that we could have done and rallied the country to do was become more metabolic healthy. There was not an examination of that on mainstream news. So I think there's nothing conservative, there's nothing liberal, there's nothing ideological about letting this industry buy off the news. It's a day one solution. The Office of Prescription

Drug Promotion at the FDA has control over this. It's an executive agency. And just as we had dramatic and quick and robust actions to defeat and combat COVID, we've got a bigger issue than COVID right now. Our kids are absolutely on a downward trajectory. And tomorrow, the president can issue a directive to the Office of Prescription Drug Promotion and say, we're not going to let the pharmaceutical industry buy off the news. And we're the only country other than New Zealand that allows this. It is absolutely unprecedented. And it controls our information. But it also actually influences doctors too,

because the science shows really clearly that when a patient asks for a drug they see on TV, 60% of the time they get that drug. Well, of course, once you get someone on a chronic disease treadmill, again, not impugning any individual motivations, that's great for the system. Ozempic, they're literally, you couldn't create in a lab a better economic model where you have to, somebody has to both take a injection for the rest of their lives and that injection implicitly says to that patient that they don't need to eat healthy. Right. It's perfect.

They're inevitably going to keep coming back to the doctor's office again and again. They have to for re-prescriptions. Yeah. And by the way, the pharmaceutical approach to chronic disease can be useful sometimes, but it really isn't the solution. And people who are listening obviously know the focus of functional medicine and how much of a better root cause analysis that is in a system for getting to the real problems and fixing those problems often without medication.

So I think it is huge. I also think maybe we can't limit, uh, you know, marketing to, uh, everybody for junk food, but we surely, you know, have, have eliminated television ads for cigarettes. We surely could eliminate ads for ultra processed food to children. And, and I think, you know, we're, we're one of the few countries that also allows that. And I think in Chile, they had an incredible example of how they basically repeal that ability for food industry to market to children there was no ads between 6 a.m and 10 p.m on any media they removed all the cartoon characters from all the cereal boxes and they

basically put sort of warning labels on the food and what they found was that the biggest impact was removing the ability of these companies to market to these kids and to hijack their brains. And I think, you know, whether, you know, it's a free speech, First Amendment thing, I think we do really clear. The data is so clear on how ultra-processed foods are harming us and how it harms kids. For every 10% of your diet that's ultra-processed food, your risk of death goes up by 14%. It's the number one killer globally on the planet. It causes depression. It causes obesity. It causes all hosts of chronic diseases. It dysregulates our appetite. There's just no

lack of evidence. And I think, you know, if we could also, I would say, add to that executive order the restriction of food marketing to kids, it it would be huge I don't know if the president can do that, but I think you know, that's a congressional thing, but There's a potentially aggressive act the president can take You know, I would urge a president to get a aggressive lawyer I think there we do we are an emergency right now and that is an executive agency. Yeah, so I think we need strong leadership from the only politician in America who's responsible for everybody, which is the president. And I think that is a potential executive action to take.

You're calling this a national emergency. It is. Well, we are in a national emergency. And I think you want to be careful about abusing that power. But if there is one national emergency of our generation, it is that we are taking children and absolutely annihilating their metabolic health and microbiomes with these toxic foods. I mean, again, it's not a free speech issue. If you say metabolic health, I would also add their mental health.

The mental health. Well, the microbiome is highly tied to mental health. It's where serotonin is produced. Ozempic is now being investigated by the EU for causing a sharp increase in suicidal ideation. Why? Because it's gut dysfunction. It's messing with your, literally with your microbiome, with your gut, which produces 95% of your serotonin.

You know, the brain-body connection. Of course these things are connected. So I don't think many people think we should be advertising cigarettes to kids. And as you made the point, you do a brain scan of a kid with highly processed food with sugar, it's a to have some limitations on advertising highly addictive substances that are very harmful, that are causing millions of unnecessary deaths and early deaths to kids. Thanks for listening today. If you love this podcast, please share it with your friends and family. Leave a comment on your own best practices on how you upgrade your health and subscribe wherever you get your

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