The Dylan Gemelli Podcast - Episode #148: The TRUTH about TRT (Testosterone Replacement Therapy)!! Do You REALLY Need TRT? Is Testosterone use "dangerous"? What blood markers should you check? Is it "cheating" and more!!

Episode Date: July 25, 2026

Episode #148:  The TRUTH about TRT (Testosterone Replacement Therapy)!!  Do You REALLY Need TRT?  Is Testosterone use "dangerous"?  What blood markers should you check?  Is it "cheating" and more...!!    Testosterone has quickly become the most talked about, misunderstood and polarizing hormone on the planet.  Average testosterone levels are at an all time low WORLDWIDE!  Not only is this a growing problem for men, but also women, especially when going through menopause.  There is fear, misunderstanding, misuse and lack of proper care making it a prevalent problem when it comes to PROPER dosage, treatment and type of testosterone used.     In this episode I discuss myths and realities of testosterone and TRT therapy.  I have spent over 15 years working with clients, practitioners, clinics and drug companies, studying and learning the complexities and science behind these truths and misconceptions.  Year over year, I have monitored, coached and also been on therapy myself and have worked to help everyone improve their quality of life in the right capacity.  Testosterone deficiency can destroy quality of life but misuse can create new problems that can be very problematic, so getting through the misinformation and "broscience" is imperative!  My next focus is on blood panels.  The monitoring of bloodwork, knowing which numbers to look at and what key warning signs are is often times missed or worse, not monitored.  I dive into the key numbers and markers to track and watch!  I move into what "healthy" numbers look like for men and women, explaining the complexities of each individual and the need to focus on person to person as opposed to chasing a non existent "one size fits all" approach.  We then move into the role lifestyle plays into our testosterone levels and what kind of changes we can make to help optimize our levels. I finish with different types of testosterone, how to dial in dosing and long term usage.    My goal is to teach everyone, without click bait or fear mongering, keeping it to relevancy and importance.  Hormonal imbalance can decimate quality of life and testosterone is a key hormone for both men and women.  DO NOT MISS THIS EPISODE!!    _____________________________________________________________________________       Today's episode is sponsored by TIMELINE   To PURCHASE MITOPURE visit Dylan's landing page and use code DYLAN to save 20% OFF!! https://shop.timeline.com/DYLAN   _____________________________________________________________________________ The Dylan Gemelli NAD optimization protocol powered by JINFINITI:     Save 15% site wide with code DYLAN   https://www.jinfiniti.com/dylan-gemelli-protocol/?_ef_transaction_id=&oid=4&affid=131 ______________________________________________________________________________   JUST THRIVE HEALTH Use my link below and receive 90 DAYS OF FREE Digestive Bitters when you sign up for 90 days of the Probiotic!!! https://justthrivehealth.com/DYLAN         ALSO Take 20% off at Just Thrive SITE WIDE with my link below https://justthrivehealth.com/DYLANGEMELLI   ________________________________________________________________________________________     The worlds FIRST EVER Topical Glutathione at AURO WELLNESS!  SAVE 15% with code "DYLAN" https://aurowellness.com/dylangemelli _______________________________________________________________________________________________     Get the Apollo Neuro for $99 OFF!! USE CODE GEMELLI to save https://apolloneuro.com/gemelli   _______________________________________________________________________________________________   Qualia Life Supplements:  Save 50% off PLUS AND ADDITIONAL 15% off with my code DYLAN   www.qualialife.com/dylan   ___________________________________________________________________________________________   TRULY Increase Your NAD LEVELS with WONDERFEEL NMN: https://getwonderfeel.com/?utm_source=DylanGemelli&utm_medium=podcast                       Follow Dylan on Instagram, Facebook, Twitter and Tiktok @dylangemelli and PLEASE SUBSCRIBE and leave reviews!!           MAKE SURE TO GO TO DYLAN'S YOUTUBE CHANNEL for MORE video content!!    https://www.youtube.com/@DylanGemelliBiohacking       Email Dylan for booking, collaborations and/or to apply for the Dylan Gemelli Podcast DylanGemelli@gmail.com     Visit Dylan's Homepage https://dylangemelli.com

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Starting point is 00:00:17 Your biology may not be the same in your 40s as it was in your 20s, but your standards and goals can be even bigger. We're at a time where we have more tools and methods to not just live longer, but also healthier with better results as we age. Aging is no longer viewed as a decline. It's about optimization and time efficiency. Training smarter and more efficient is a new standard, and we now know how to get more from the workouts we are already doing. Now, chances are your supplement stack is missing a much healthier foundation. So enhance it with much, Midapear, a targeted supplement that revitalizes your mitochondria, the powerhouse of your cells. Mitochondria are crucial to overall health, not just energy production. Protein builds muscle.
Starting point is 00:00:58 Cretine supports power. Might appear helps support the cellular engines that power both. When your cells thrive, everything follows. So claim your free aging muscle protocol guide and free sample of might appear gummies from Timeline at timeline.com slash Dylan. It's the science back breakdown of exactly what's happening to your muscles as you age and how to fight back. Why does everybody now think that you have to be on TRT to be healthy? Why does everybody think that if you're on TRT that all of a sudden you're cheating or you're going to be this mass monster
Starting point is 00:01:30 or have this huge advantage over everybody else? Why is it the biggest thing at every single clinic you go to where they're putting everybody under the sun on TRT whether they need it or not? First of all and foremost, I am well known as being one of the, biggest TRT advocates on the planet, meaning that if you need it, if you have a hypogonato condition and your body absolutely needs to be on it, then yes, yes, yes. It will improve your quality of life. It will allow you to feel rejuvenated and alive again. But if you don't need it, if your body's producing testosterone, okay. And for some people, optimal range is going to be a little bit higher than others and some people are going to be just fine at a little bit lower range. But if you
Starting point is 00:02:13 are doing just fine. There's no reason in the world to try to fix something that's not broke. And there are other ways to boost testosterone levels if you just need a small boost as opposed to just going full-blown TRT. Now I will say this. Steroid users, which a lot do watch my channel. I'm not going to tell you to get on testosterone boosters to fix anything. I think we all know at this point in time that if you have used steroids, that chances of a testosterone booster helping you are pretty damn slim. You could always use it as a secondary or even third look to try to give you a little bit extra bump, but to totally rely on it is just, it's not accurate. I went through years of that with different companies and people trying to feed me studies and convince me and made me look quite foolish to be honest with you, where I'll never sit up here again and tell everybody, well, use this for your PCT or this is going to cure you, no, it's not. Now, if you're a non-steroid user and you don't have a severe condition or a woman that
Starting point is 00:03:13 may have a lower condition, then we may want to look at it first just to try without jumping on, but then again, we need to temper our expectations and realize that a lot of it is lifestyle changes, foods that we're eating, et cetera, and that might just add a little bit to it. But there are so many things that people need to look at before just jumping right on to TRT. Let's start with the blood panels. This is the most important part of all aspects of our life. This is how we know what is going on within our bodies or not. So whether we're looking at TRT, whether we're looking at diagnosing any sort of issue that we're having symptoms of, the blood panels and the blood work are going to tell us everything.
Starting point is 00:03:52 The first thing that we have to understand is, especially when we're getting our testosterone tested, is how do you go into the test? Because you can have a skewed number if you're not fasted. If it's not first thing in the morning, if you've been working out, if you've been doing something stressful, these will skew your numbers. So oftentimes when I have clients, I'll tell them, okay, it's good to be. we got this test now we need to go back and just make sure before we do something that we may not need to do that's step one step two is actually getting the proper panel when you go to a regular doctor or practitioner generally speaking they're going to give you a basic panel which is going to be a cbc and they call that a complete blood count which it's not complete but it is it is helpful and then a
Starting point is 00:04:35 cmp which is a complete metabolic profile once again not complete but it will cover some of the bases we liver, kidneys. Sometimes it will hit different electrolytes that we need to look at, depending on where you're getting the testing done. And it'll look at some potentially basic cholesterol parts too as well. Not always, but sometimes you'll have to add those in extra. There's a slew of other tests that we need to look at before and as we get started. You need to know if you have prior family history and conditions. You need to know if you may have an elevated PSA, high blood pressure, high cholesterol. These are all very, very, very. important markers to look at before you jump on something like testosterone and you need to know
Starting point is 00:05:17 these in general you need to know your family histories and you need to check to see if like for me i didn't know i had an lp little a gene that is an inherited thing i went through life testing but never testing that only getting basic cholesterol numbers when those are not foundationally what we need to know if we have an issue thankfully i still caught it but it was at a point where i developed some plaque in my arteries that probably more than likely could have been avoided. So don't fall into this. Oh, I'm only 20. I don't need to ever test. Yeah, you should. Now, as we get older, we need more maintenance, more testing to ensure that we're not having problems creep up out of nowhere. Because before you know it, boom, they hit you one day, you wake up and you're going, well, what the hell just happened? And it was sitting
Starting point is 00:06:02 there the whole time, but you never took the time to actually look and check. So we need to get very extensive blood work done covering all the bases. We need full metabolic profiles, cardiac IQ, which is that full cholesterol panel. We need to look at your prostate. We need to look at estradile, progesterone, prolactin, all of these things that are never looked at. I want to see all of those. You also want to see your heavy metal exposure. Different tests that nobody often looks at when you're going to a basic doctor. But now more than ever, functional medicine practitioners, they're all looking at these panels because now we have a better understanding of mercury, mold, toxins. Our environments are creating a lot of the problems we have and low testosterone feeds right
Starting point is 00:06:45 into that. I want to try to figure out, are you highly stressed? How's your sleep patterns? Are you drinking? Are you smoking? These are all factors that play into a low testosterone level. And we can work on these and try to fix them before putting somebody on TRT. That's one big issue right there. is a lot of these clinics now especially, they're putting people on TRT that don't need it. Everybody's different. So some people may have a total or free testosterone number that looks okay on paper,
Starting point is 00:07:12 but they may still fill and have all of the symptoms of low testosterone. So then we want to look at, okay, what are the root problems here? Are there other panel markers that may show why you're filling this way and can we try to fix those first? And let's say I have somebody in that does show a low testosterone number. I still need to be doing my due diligence trying to figure out, wow, your SHBG, it's high.
Starting point is 00:07:32 elevated. If we fix that, we can free upbound testosterone and shoot that number back up and, wow, maybe we'll fix this. Maybe we won't. But there's panel problems that could show their ugly heads that we could fix and avoid putting you on TRT itself. So finding somebody that actually knows how to read a blood panel, and what does that mean? Well, if you go do your own blood panels, which I do encourage people to do, the problem is if you go to Quest, Lab Corp, all any of these places, is these ranges now, they're this far of a gap where they're telling you that something's average and it is not. I see people teetering on the red line and it's saying that they're average and like one bad morning or something that they ate or slip bad and that thing could slip right into
Starting point is 00:08:16 a danger range. These ranges are insane. We want optimal ranges and you have to find somebody that understands where optimal ranges are anymore because they've widened these gaps so much based upon public average. Well, guess what? The world, especially where we live in America, is the unhealthyest it's ever been. So basing it on average is not what we want. We need to find optimal standard ranges
Starting point is 00:08:40 and then look at those and find somebody that understands where those are. And there's plenty of places out there that do. There's functional medicine doctors and there are different types of companies that I can recommend to people that will help you find those proper ranges. There are people out there
Starting point is 00:08:56 that actually care that try to teach people the right way to do this. We are too quick to try to just treat everything instead of prevent. We need to try to find root causes and prevent before we just treat, treat, treat, treat, treat. That's embedded into everybody's head now. What people call alternative medicine, like peptides, for example, and other different kinds of, I mean, even Chinese medicine. These are called non-conventional. No.
Starting point is 00:09:25 Non-conventional is our medications. We're taking these, we're making them synthetic, we're altering them, we're taking natural things that God put here for us to use and we're altering them. That is non-conventional. So let's kind of address that as well. We need to try to alleviate problems and not just treat them. So there could always be things hidden in your blood work that will show, wow, if we fix this, boom, no testosterone problem anymore.
Starting point is 00:09:52 Now, as we age and as we get older, we put our bodies through things. things. Yeah, the likelihood of that happening does lessen, but there certainly are different ways and means of going about this. Then I see another big issue, which is people going to regular doctors, not understanding that they're GPs, which is a general practitioner and not really well-versed at all in what they're doing. And I see so many people getting put on the strangest injection cycles, for example, and their testosterone levels are all over the place. They feel like crap because the esters that they're being put on, it doesn't make any sense. They're peaking and troughing. So when you peak, yeah, your testosterone hits a certain elevation, you feel great. Then a week later,
Starting point is 00:10:33 you feel terrible because your injection cycles off. So this is another issue that I see people running into constantly. We have a lot of confusion here, blood panels, because you oftentimes are not getting the right readings. And then when you do get the right readings, they're not being given to you properly because you're being told something that may or may not be true. You're not getting enough reading. You're not digging deep enough. And then you're not looking for the actual problem or cause. And a lot of this comes down to having the right doctor to question you, to get into your family history to figure out your lifestyle and things that need to be changed. My goal here is to not scare people from TRT, not definitely not tell people to not use it. It's to avoid
Starting point is 00:11:15 people from using things needlessly. Just remember something here. Anybody can tell you whatever they want, and that's fine, and you can always try to test this out yourself, the minute you get on TRT and you start using it for a long time and the longer you use it, the chances of you actually recouping your natural testosterone production are slim to none. And I know some people are going to bitch and complain and argue about that and say, oh, no, you can recover it.
Starting point is 00:11:38 I didn't say that you can't. Not once did those words come out of my mouth. I said the likelihood is going to lessen and lessen and lessen, and the older you get and the longer you use it, it's going to shrivel up into the lowest of nth degrees of the likelihood of you getting it back. That does not mean it's impossible. I know people love to put words in people's mouth and get all pissed off and angry. Get angry all you want.
Starting point is 00:12:02 I am simply trying to pass on everything that I've seen and observed for all of these years. I'm not here to scare anybody. I'm certainly not here to confuse anybody. I'm here to help you overcome all of the obstacles that can interfere with your personal health, growth, and journey. I've seen way too many people do things needlessly and go through things needlessly. Other markers we want to make sure that we're looking at throughout. Really get deep into your cholesterol. ApoB, LP-L-P-L-A, particle sizes.
Starting point is 00:12:30 These are all so important because testosterone use can certainly have an effect on your cholesterol. Now, we can get into a whole LDL total cholesterol debate later because there's a lot of misinformation about that and people trying to, doctors trying to get you to drain your LDL so low. Your body relies on cholesterol in so many ways. I mean, fuck's sake. Think about your cellular membrane, which is I know, and I've said this to, the mitochondria is the powerhouse of the cell. But if your cellular membrane, which is protecting your cell is not healthy, your mitochondria is rather useless because it's not protected. So I would think that we want to make sure that the cell itself is protected. And that may be the most important
Starting point is 00:13:11 part of the cell because there is no cell without the protected layer. And that's where cholesterol comes in because the cell relies on cholesterol to protect it. And that's why healthy fats are so important. So these misconceptions out there, they are insane. And so we have to be very careful. Let's talk about the testosterone dose itself and the use. The first problem that I see is the dosing. Standard, you will take five to seven times your dose and that should be what your number ends up being for total testosterone. So let's say I'm running 100 milligrams a week. You should be in the 500 to 700 range.
Starting point is 00:13:47 Now, if you have a severe condition, you're probably going to be on that lower end, but most people are going to be closer to that seven times range. So you'll be closer to 700. Now, I see too many people using way too much. I have no problem getting the testosterone levels high, but there is a certain point where it's too high and it's too hard on your body.
Starting point is 00:14:05 It's too much. And I know, I know, I know the guys that want to say, You got to use so much to get big and huge. That's not the goal here. That's not what TRT is. TRT is not running a cycle. TRT is not about getting as big as you can. That's not going to make you live longer.
Starting point is 00:14:21 The goal here is to live longer, not try to get as big as we can and live shorter, because the more size and weight that you carry, the shorter you're going to live. And the higher levels of testosterone that you have for too long is too much stress and strain on your heart and body. It will take years off your life, so there's a fine line.
Starting point is 00:14:38 You know, when you start getting over the, range, that's unnecessary. That's where we're starting to, okay, this is too much. You can always go too high or too little on anything. It's not as though there's a range where you can just go forever. You have to stop. That's why I try to temper these and tell people, look, you're going to do this, you're going to do it forever. You want to make sure that you're doing the right proportions to what your body actually needs to be the healthiest. You don't go take 75 different pills that you're given. Let's say that you're given a painkiller for your teeth. You don't go take 100 of them. You take one the one that you need that's not how it works if you get put on a moxacicillin you're not taking the
Starting point is 00:15:14 whole jar in one setting because you want to get fixed right away you're not taking the whole pill bottle in one setting because you want your sickness to go away immediately that's not how it works so there is a fine line so you got to be careful when people say oh i'm going to blast and cruise that's not TRT, my friends, that's you running steroid cycles and then cruising back on testosterone and then blasting again. TRT is just staying on it, taking care of your body with what it needs. Most people do perfectly great with 100 to 150 milligrams. Like you said, one size fits none. Everybody's different. Everybody's got different conditions. That's for you to find out and figure out. But you have to continuously monitor your blood work, see how it's affecting you, see how it's affecting your
Starting point is 00:15:58 not only your testosterone levels, your estrogen levels, because you know, you take testosterone and it converts to estrogen. You need to see, is it affecting my prostate? Is it affecting my blood pressure? My liver, my kidneys, my cholesterol. Everything needs to be closely monitored because it's all tied in together. And the way that you live, the way that you eat, I assure you, just because you take TRT doesn't mean that you're automatically going to become some mass monster, be able to lift everything in the gym. People have this misconception and they're being told all of this, this is nonsense. you will be able to get lean muscle again because if you have low testosterone, you're going to have an inability to do that. You will get your libido back. You will feel alive again. You will get your energy back. But you're going to be living how you're supposed to be living. But you go too high. That's when you're going to run into problems. So that's why it's fine tuning and seeing what your body can and cannot handle. But monitoring is essential. And that's why I say you have to get full panels. You got to get a real good understanding. I'm going to do a video later and just do a rundown of all the panels that one needs. to be doing and checking, I would recommend at a minimum if you're on TRT three times a year. Anybody that you start getting into your 30s and 40s, you should be doing blood work twice a
Starting point is 00:17:04 year. So this isn't just for TRT, this is for anybody in general. Make sure that you're monitoring yourself. But especially if you're on TRT, there's so many things that can come up. Just because you're doing well with it now, it doesn't mean you're going to forever. Certain things can happen. And that's why if you stay on top of it, you can fix something right away. And then another thing, like I brought up earlier, the way that you eat, the way that you sleep, your love of of stress, these are all going to contribute. So just because you start taking it, if your environment around you doesn't change, it's not going to help. It'll help a little bit, but you'll never get fully healed or acclimated properly because you're not living the proper way. I know some people don't like
Starting point is 00:17:40 some of the things I say because it's not rainbows and unicorn all the time. So what I'm trying to do is make sure that you're getting more rainbows and unicorns in your life, more happy days, more joyful days, more days of energy where you're not worried and stressed about your health, where you feel great. But you have to put the work and the effort and the time to do that. These things, they don't just magically happen. So I'm trying to teach you how to do it. And I'm trying to help you avoid causing yourself problems, creating new ones, saving your money, saving your health, saving your sanity. So that being said, stay tuned for plenty more to come. Dylan Jameli, signing off.

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