The Dylan Gemelli Podcast - Episode #25: Dylan Gemelli on The Well Beyond 40 Podcast with J.J. Virgin! ”Reversing irreversible heart markers”, micro dosing GLP-1’s, A deep look...

Episode Date: May 10, 2025

I had the honor an privilege of being a guest on J.J. Virgins amazing podcast "Well Beyond 40" and wanted to share with all of my listeners!   Here is the breakdown of the episode DIRECTLY from J.J.'s podcast feed   "I am on a mission to show in the most positive manner just how far off a lot of these people are and to show people there's hope and to teach them how to do it without completely eradicating their health." - Dylan Gemelli I sat down with Dylan Gemelli, a prominent figure in the fitness and biohacking industry who's transitioned from the bodybuilding world to becoming a cellular health expert. Dylan shared his incredible journey of rebuilding his life from scratch, discovering peptides and SARMs long before they became mainstream, and his personal battle with heart disease that led him to prove medical professionals wrong about what's possible. We dive deep into the world of peptides, cardiovascular health testing beyond standard panels, and why the hierarchy of health should include strategic supplementation for optimal aging. Dylan's passion for challenging medical dogma is infectious, especially his evidence that LP(a) levels can be lowered despite conventional wisdom saying otherwise. What you'll learn :• What peptides and SARMs are and how they differ from harmful substances like steroids • Why standard cholesterol panels miss the most important cardiovascular risk markers• How Dylan lowered his "unchangeable" LP(a) levels by over 230 points when doctors said it was impossible • The hierarchy of health supplements everyone should consider, starting with creatine for women of all ages • Why micro dosing GLP-1s may be the ultimate longevity hack for improved metabolic health • How specialized peptides can accelerate healing, improve sleep, and support cellular repair • The truth about NAD+ supplementation and what delivery methods actually work • Why building and maintaining muscle mass is critical as we age, especially for women   FOLLOW the "Well Beyond 40" Podcast   https://podcasts.apple.com/us/podcast/well-beyond-40/id911502027   ________________________________________________________________   Today's episode is sponsored by Apollo Neuro!   Get the Apollo Neuro for $90 OFF!! USE CODE GEMELLI to save https://apolloneuro.com/gemelli _______________________________________________________________________________ To PURCHASE MITOPURE visit Dylan's landing page and use code DYLAN to save 20% OFF!! https://shop.timeline.com/DYLAN     TONUM supplements for the MIND AND BODY!   USE CODE "DYLAN" to save!!  https://www.tonum.com/DYLAN     THE BREAKTHROUGH MIMIO HEALTH FASTING MIMETIC SUPPLEMENT!  20% OFF with code Gemelli  https://mimiohealth.sjv.io/c/6588260/3323599/30611     TRULY Increase Your NAD LEVELS with WONDERFEEL NMN: https://getwonderfeel.com/?utm_source=DylanGemelli&utm_medium=podcast     MESCREEN: The world's first and only at home mitochondrial efficiency test Save $100 with CODE   DYLAN   https://mescreen.com/cart/47561239626013:1?discount=&ref=DYLAN       HIRE DYLAN ON THE MINNECT APP HERE: expert.minnect.com/@DylanGemelli     Follow Dylan on Instagram, Facebook, Twitter and Tiktok @dylangemelli and PLEASE SUBSCRIBE and leave reviews!!   MAKE SURE TO GO TO DYLAN'S YOUTUBE CHANNEL for MORE video content!!    https://www.youtube.com/@DylanGemelliBiohacking Email Dylan for booking, collaborations and/or to apply for the Dylan Gemelli Podcast [e-mail] Visit Dylan's Homepage https://dylangemelli.com

Today's episode is sponsored by Apollo Neuro. Apollo is the leading doctor recommended wearable technology. Apollo's award-winning smart vibes AI works effortlessly behind the scenes, automatically integrating into your life to deliver gentle, personalized vibrations that activate your vagus nerve, helping you fall asleep faster, stay asleep longer, and wake up balanced, focused, and ready each day. Not only that, but the Apollo Neuro is the first and only wearable that improves your HRV. Apollo is effortless. Simply wear it throughout the day and night and let it do the work

for you. It's safe for anyone and everyone with no side effects and is the only wearable that can be worn anywhere on your body. Optimal health requires both the mind and body to be in line and Apollo is the key to establishing that connection. Check the description below to save $90 with my special discount. Take control over your health today with Apollo Neuro. I'm JJ Virgin. dropout, sorry mom, turned four-time New York Times best-selling author. I'm a certified nutrition specialist, fitness hall of famer, and I speak at health conferences and trainings around the globe. But I'm driven most of all by my insatiable curiosity and love of science to keep asking questions, digging for answers, and sharing the information that I uncover with as many people as I can.

And that's where you come in. That's why I created the Well Beyond 40 podcasts to synthesize and simplify the science of health into actionable strategies to help you thrive. In each episode, we'll talk about what's working in the world of wellness, from personalized nutrition and healing your metabolism to powerful aging and prescriptive fitness. Join me on the journey to better health so you can love how you look and feel right now and have the energy to play full out at 100. Don't miss an episode.

Subscribe now at subscribe to jj.com to start unlocking your healthiest, most energetic self. Want to listen to this show ad-free? Head over to subscribe to jj.com and start your ad-free experience today. Okay, full disclosure, I've been dabbling over the last two years, I guess, with peptides. maybe it's been three years now.

And so I'm always interested to talk to people who are further ahead on their peptide journey than me. And so that is what I'm going to be talking to Dylan Jameli about today. He is a prominent figure in the fitness and biohacking industry. He has got his expertise in health fitness and performance enhancement. He's also the creator of the Dylan Jameli podcast, and he has written e-books on peptides, sarms, and neutropics. We're going to be digging into peptides and SARMs a bunch today.

He's a national association of sports medicine certified personal trainer. He's fitness and nutrition and weight loss specialists. And I met him over at Eudamonia this year. He came and took my exercise snacks workshop. That was really fun. It was the first time I'd done an exercise class in, gosh, 25 years. I was like, these are fun. I should do this more often.

And anyhow, we are talking all about that, but we're also doing a deep dive into kind of the latest in cardiovascular health, which is such an important topic. One, I don't talk about enough. I need to bring some more people on the show about it because this is the number one health risk, and we don't talk enough about it. So we're going to be talking about the latest tests, some of the important things you can do. And then, again, a bunch on peptides. So a fun interview kind of goes all over the place. So kind of buckle up for the wild ride. And I'll be right back with Dylan Jumeli.

All right. So we've got you. You're a trainer. You're a nutritionist. You're a cellular health expert. Dylan Jumeli, you're on the show. And we are going to dig into peptides, sarms, and neutropics. I almost feel like saying, you know, lions and tigers and bears.

It's like peptides, utrophics, and sarbs. I think what we need to start with is how did you get into all of that? And then I want to unpack them all because I think most people don't know what the heck they are. you know, long story that I'll try to keep shorter. So I kind of had to start my life over from scratch and 2011. I made a lot of poor choices when I was younger. I was modeling. Really, you're the only one.

Yeah, right? Really bad lifestyle. I was modeling all over the world. I was in Italy, Europe. I was acting. And, you know, I'm not going to make excuses. It was my decisions. I was raised well given everything.

and I was just a jerk. And I got myself into trouble, started from scratch. And granted, I started from scratch in Hawaii because that's where my parents lived and where I moved. Who, who, who. Right, right. So it was 2011. And I literally had nothing but some clothes, a bed, and I was in my mom and dad's basement at 30 years old. So you can imagine going from like having everything to nothing.

And I mean nothing. So I started to do a ton of research. just I was figuring out with my life was I want to be a trainer. I'm all about health. This is it. So I got into bodybuilding forums and started studying supplements, testosterone boosters. And I had studied steroids because of baseball because I was a big sports fan. And so I got into that world more, but I was more on the side of trying to teach people to not use them and the side effects and coaching. So what they, a company found me and said, we want you to start doing YouTube videos and we're going to push you to the moon.

Nobody's talking about any of this stuff and we want you to do it. And I had just gotten out of legal trouble, right? So I said, well, I said, let me talk to my attorney and see if there's any legal trouble here. And there wasn't, you know, talk about whatever. Just don't be a part of selling stuff. Obviously, I'm not going to do that. So I studied my butt off. And when I tell you, I studied my butt off, it was I was up until two and three in the morning on the computer every night, just reading, reading.

well, in the midst of all of this, I fell into this world of peptides and sarms that no one had tapped into or knew about. And I used SARMs. And after using them, I thought I found the Holy Grail, right? Because it's like, wow, these have, they're not like steroids. They're not going to cause you all this suppression, all of these side effects. So I just went full bore at them. Peptides at the time were not popular in the bodybuilding world because they didn't put on a bunch of size. They didn't do all of these crazy things.

And there was only like six or seven to choose from back then. And how long ago was this? 2011 was when I stumbled upon you were so early. Yeah. Oh my goodness. Well, when you got onto an underground peptide site, there was roughly seven or eight you could buy. And it was like Ipa Morel and CJC 1295. And then Melanatan 2 and which I experimented with and basic GHRPs.

I mean the basic basics. Okay, most people have no idea what you've been talking about and they don't know what SARMs are. So we're going to get, don't worry, we will define all of this. By the time you leave, you will be an expert like Dylan is. You also know which things to try and which things to stay away from. And I'll tell you my funny Melanatan story. Oh, we're going to have to go back and forth because I have a horror story for you too.

We'll go back and forth. But, you know, it just progressed. And then when there was these things called pro-horror. So for people watching, in short, pro hormones are basically steroids that were legal at the time that you could sell. They were designer steroids. They're steroids. Let's just call it out of it. Well, they were sold over the counter. And honestly, they had all of the makeup of steroids with some additives in there to make them on the legal side without actually being an actual steroid. But the way that they were made and methylated, they were worse for you than steroids. Wow.

And they banned them in like 2014. And after that happened, all of these companies were stuck with hundreds of thousands and sometimes million dollars of raw materials. And these were categorized as steroids now. So that was a schedule one drug. If you got caught with these, you were going to prison. Okay. So people stopped selling them.

So what did they do? They discovered SARMs. They discovered peptides. So they started selling SARMs illegally marketing them as supplements because what will get into is sarms and peptides sold could only be sold as research chemicals and and a sarm is what a selective androgen receptor modulator meaning it's selective to the androgen receptor so it's very selective on where it goes where steroids can cause you all of these harms because sarms are selective and go to a certain androgen receptor that's mitigating a lot of the side effects basically in in short easy terms we could get more scientific into it but

we're looking at far less side effects like for instance prostate's a big concern with steroid use you're not concerned with prostate with sarums use because it's selective um but what happened was they starts putting these into capsules and selling them and then this big sarms explosion has taken off ever since the problem was a lot of these places were putting their pro more pro hormone powders into the sarms and selling them a sarms so now you've got all of these articles everywhere that sarms caused these problems and that problem when people were taking pro hormones without really knowing it. There's no testing here. They're not FDA regulated. You don't know what you're taking, just like a lot of the supplements we take now. You know, some are good, some are regulated, and some are just thrown in and you don't know what you're getting. So I've went through this whole evolution, and then that brings us closer to today where peptides started to be prescribed. You know, 2019, 2020 is when people started kind of prescribing them.

And then you know now the last two years, it's just blown through. the roof where you got more biohackers and more doctors and it's just readily talked about and discussed and with good reason by the way and so I have gone through this whole process and evolution and now I'm on the doctor's side I was invited to speak at Mr. Olympia and that's where I transferred into the biohacking community after October this year and I've just it's been a big splash for me because it's like who I really am I've been in this world of bros and that's not who I am you know it's it's what i had to be to find my niche and now i'm around the and i love those people don't get me wrong but that's not who i am and now i'm around the people that i really truly am and

then i get to meet people like you and and i relate with so much better and i could talk to all day and now my focus is kind of on the cellular health side and the biology side and the health side and i do a lot of i didn't get into this with you before but i i found a heart condition on myself so i have The last two years, I have put so much time into cardiology studies and cholesterol, LP, LP, LP, A, A, POB, real in-detail, intricate stuff to help people. Oh, well, let's break into that, too, because, you know, it's interesting to me that cardiovascular health still gets the least amount of attention. And it's the number one killer.

It's like, you know, especially when you talk about women's health, it's breast cancer, it's osteoporosis. These are important. But heart disease is what ultimately kills them. majority of people. Yes. So, you know, I definitely want to unpack that as well. So, and I'd love to talk about it in the context of peptide, SARMs, neutropics, like, you know, what all we can be using. Before we get into that, you define SARMs, define what a peptide is and what a neutropic is as well, just so we have that baseline. So, you know what I'm going to do

here, too, because I have my e-books here, and I get into these, too. But, you know, you know, But, I mean, peptides are really just, they're just amino acids and they're, they're composed of single chains of amino acids and that makes a relatively large peptide, right? I mean, that's all that it, if we're just keeping it as simple as we possibly can, that is literally all it is. It's just, amino acids formed into a peptide chain. And so there's different numbers on each one and all of that. but it's not as difficult as it sounds. And a lot of these, like for instance, we know BPC 157 is the most talked about peptide in general right now at this time.

And I can confirm that on sales of underground sites because I get all the data from owners because I study and keep ahead. And it's just produced naturally in your gut. Now, we're taking it exogenously when we inject it, but it's something natural. it's a lot more safer and optimal. Most of these peptides, they really aren't going to cause you harm unless you absolutely abuse them. Now, you and I have discussed GLP ones, and that's a different story on misuse.

But we're talking just in general, the safety and efficacy of these are incredible, and there's years upon years of study. And I am such a big proponent of them more than I ever have men. It is just, I mean, you can attest to this. There's so many that do so many different things. I am fully behind them 100%. Where do you think they fit in? Because I kind of have my hierarchy of health. And I'm hoping with the new administration things are going to shift because they've been this underground thing.

And it's sort of like making supplements underground. I like it's ridiculous, you know. And my only thinking is that it threatens the pharmaceutical companies because literally, if you were eating well, exercising, dealing with your stress, believed in a higher power, had great relationships, you know, did the food to basically what you needed, use supplements to correct any deficiencies, use peptides where you needed, like, I don't know that you'd ever really need pharmaceuticals at all. So therefore, you know, I see the, people don't, listening probably don't realize that a lot of these things have been taken off the market, that I remember

my first time buying some of these things because I wanted some very specific peptides for my son with this traumatic brain injury. We had to use Bitcoin and buy it from this Russian company. And I'm like for experiment, it was only for animal use. Like all this ridiculous stuff. I'm like, what is going on here? But similar to like even stem cell therapy, some of the stuff I was able to do for my son, you couldn't do.

And, you know, I have friends now going to Buenos Aires to do certain things. It's like it is crazy what we're not allowed to do. So where do these fit into your, like, let's walk through, your hierarchy of health and how you would utilize these. I'm so glad that you brought up not hopefully needing pharmaceuticals with the use of things like this because that is exactly where I was going to go with this. If you go down a list and like you're talking right now, so if you try to go get certain things prescribed, there's only so many things that you can get prescribed anywhere from any

clinic or any doctor or anything like that. your list is going to be quite short on what they can actually prescribe to you. There's hundreds and thousands of peptides to choose from. Now, sifting through where to buy them safely is a whole other thing that we can discuss as we go on. But in terms of my hierarchy, I'm always going to start with your basics, your nutrition, your sleep, you're just like you, like with nutrition, the amount of protein intake, and having our macro and micronutrients correct. But then if we're looking past that and we're looking at supplements and there's basic things like creatine that I think everybody should take. And we can talk about ages.

But I think there's such a gap there that you can safely do it. And I believe like I have my mom in her 70s on it. I firmly. Amen. Get her on chitine. Yes. I already do. It's like back.

It's finally back. I know. It's like sold out. Yes. And over again. Well, luckily I had a few ahead of time. So, you know, me and my wife took it and then I gave the rest to my mom. My mom, I like powder.

She likes capsules. We've got plain powder coming out next. We've got all sorts of stuff coming out. I'm looking forward to that. You know, it's interesting. I think that when you look at something, because I always look at orthomolecular first. So our body makes creatine, and then we should get some from diet. So why wouldn't this be something you would be starting from a young age in that?

And if unless your kids are eating fairly rare meat and fish, which likely they're not, right. It's something you'd want to throw a little bit in their smoothie. Absolutely. And, and, you know, this is funny because when I was in high school and I mean, I'm not old, but I mean, I'm 43. So, I mean, we're talking in the later 90s. We were, that was what we were starting to take.

I was 14 when I started taking it. I had some gaps in between there when I was partying too much. But in general, I've taken it most of my life. I mean. That's the guys. the gals weren't the same. No, no, no, no. Like, we did not touch it because it was a bro thing.

Yeah, no, no. Honestly, I would say just in the past few years is when we really started talking about females taking it, like, more universally and becoming more of a mainstream thing where it's like doctors and biohackers and people are talking about it now. You know this. It wasn't talked about like that. And, you know, I still talk women off a ledge with this. I still talk women off a ledge with putting muscle on, you know? Yeah. But creatine, you look at all the different things beyond just, hey, it helps you work out harder

and recover better. I mean, besides just, and I mean, you're cellular health, like just the energy that you can produce because of it, but the brain function piece of it. Yes. You know, 100%. That's what one of the things, but I was looking at the brain function. And then you know what else is like the menopausal help. different aspects of menopause, whether it be, you know, sometimes with the emotional side effects, the cognitive function.

And then you know this, the bone health with definitely bone degradation starting at that point in time. I mean, even before that, possibly as we age, but you know that in menopause, it's really starting to hit. And even for teenagers, I mean, there's such a wide spectrum of good use here, but absolutely for females. Now, granted, the dosings may be a little different, but still, it's still something you should use. firmly behind that. So that's definitely, if we're talking supplement side, that would be number one on my list of supplements that I would recommend that people use. Now, I'm big on heart health, like I said.

So I'm there with KU10 that I think that most people should be looking at or considering taken. And I like to protect the liver. And then we know magnesium is very important. Electrolites in general need to be looked at and viewed and taken very seriously. Because when you throw those off, your heart. rhythm can go off and then there's a slew of other problems. So then we've got those basics, right? Your vitamins that you should get a lot of from food if you're eating properly. I don't like

to depend on too many things for the nutrients that we need. Those are supplements for a reason, supplemental. But then, you know, peptides are going to fall right after that for me personally. We'll get into the neutropic side of things, but that's a little different when we're talking about health because that's more like cognitive and sharp function, which I'll talk about. But There's so there's so many multitudes of peptides and things that we have. So I'm just going to name a few. Yeah. It's like, so how do you sort through all that and go which ones would be the top ones to focus on? So let's think about, okay, as we age a little bit, you know, and so we're looking at like 30 years old. We know our natural growth hormone levels are going to drop. So something like an Ipa Morel. I like Tessa Morel and myself. It's more geared towards fat loss while still adding lean muscle. So I like it. It's just very expensive. Ipa Morel and CJC-1295 are good growth hormone releasing peptides where you're you're not taking

exogenous growth hormone but they're releasing your growth hormone you know because we know HGH itself is quite expensive and there's a lot more side effects that you got to worry about I got to tell you back in the day when HGH was a big thing and I remember I was living in Palm Desert there was a doc there who taught he still does teaches all over the world on growth hormone and I had a lot of his clients coming to my gym. They all became insulin resistant. Yep. That's what I was going to say.

And that's the problem. Aside from the possibility of like acromegaly and things like, and when I say that like your heart's growing or your facial features growing and things. And that's from misuse. But then there's like there's a sodium potassium ratio. So people will complain about, oh, I got this water retention. Well, there's a thing called sodium potassium ratio where in general, when you're having those problems, it means you're lacking potassium and eating way too much

sodium. And the scale is 3,500 to 4,700 milligrams of potassium and no more than 2,300 milligrams of sodium. Well, you and I know this. Most people have way more sodium than that and like a fraction of the potassium. And everybody thinks that you eat bananas for potassium, which couldn't be further from the truth. There's a million other options. And bananas are not even close to the best choice, by the way. for the win there. Yes, there you go. But, okay, so let's look at some other ones.

BPC 157 and TB 500 are your healing compounds. And those are the ones that get the most action right now and the most discussion and with good reason. I mean, these are on a different level of rapid healing. But there's others. So epitelon for sleep, which is amazing. MOTC for like cellular and mitochondrial repair and function. GHKU copper peptide for anti-aging. PT-141 for like erectile dysfunctional or libido issues.

I mean, we could go on and on and on. What does so, and this is, I remember listening to another lecture where this guy just started rolling through him and everyone's eyes glazed over. Hey. So for someone who's listening to all this, how do you make sense of this and go, where would I start? Do you go work with a peptide dock? Like what's the process?

Because a lot of these things are injections. Some of them are oral. I've been doing a BPC 157 oral. I know it's not as effective, but I'm not going to inject myself three times a day. So I'm just, let's be real. I'm not doing it. Yuck. So, you know, which things, how would someone listen to this and go, what do I do?

So that's where the problem lies. There are some very, very intelligent people that I revert to. You know, we all have mentors and people we go to. There is like I'm getting certifications. I'm going to be going with the SSRP Institute, which is Dr. William Seeds. That's going to be the next. Oh, he's amazing. He's got me, got my brain shifted on GLP1s and made me realize what I could do to

bring my son back with his traumatic brain injury and how much that could help. I am convinced GLP-1s in a microdosed fashion like Dr. Tina Moore teaches are the ultimate longevity hack, improving insulin sensitivity, reducing systemic inflammation, like, you know, not overdosing them to shut your appetite off, using a super low dose to, you know, kind of get you back to where you would have been if your gut microbiome hadn't been trashed. You know, reducing what you should be producing. But it's made a huge difference in my son. And I learned that from Dr. Seed.

Here's where I'm going to give you some credit on something you taught me that you don't even know you taught me. I mentioned Dr. Elizabeth Yerth to you prior. So she's right with Dr. Seeds. And so she's one that I discuss a lot of my questions. I go to her. And I met her when I was speaking at the Mr. Olympia. she first told me we had a big long and we're actually going to do it again because she's going to do a controversial NAD plus conversation with me but she was the one that got me onto the microdosing with the GLPs and then about two weeks later I went to euda moni and listened to you confirm that for me and so after you confirmed it and she said it to people that I held in such a high regard I spent one thing you'll learn about me is when I want to go learn something I I'll do it relentlessly.

I'll stay up at all hours of the night. And I just put so many different studies into it. I tested it on some clients that wanted to use it. And I told them, look, we're going to do it this way. We're not going to do it your way. We're going to do it my way. And everything that I've seen confirms what you said, confirms what she said. The ability to not just degrade your, you're in that sunken face and the loss of sacrificing

of the muscle, the complete and utter loss of. which could go along with misuse and using too much. And I've seen not only people hold their weight in terms of their muscles still lose fat in the process, but feel great and look great. And I have no reason to believe that there's, I haven't seen any blood work problems because I monitor. Well, there's amazing improvements. Yeah.

And people using it, APOB finally coming down where nothing else would help. Yep. So, yeah, quite incredible. which I definitely want to talk APOB and LP Little A as well. But yeah, it's been amazing. I just know that we're doing it, that the way they're using it started out in diabetes. So that was a different application.

And I think the biggest application probably is to turn around metabolic health. And what people don't understand, that was what I was talking about at Eudamonia, is when someone's been is insulin resistant or diabetic and has been in that situation for a while. And now all of a sudden you're saying, you know what? You just need to eat less and exercise more.

Well, try to exercise when you've got chronic inflammation and you can't access, you know, glycogen because you're so insulin resistant. Now you're supposed to move more and eat less, but you're hungry all the time because you can't access stored fat for fuel. Like, that's just mean. Throw them a life raft. Let them get through this.

Give them a little bit of help as they work through it. So, anyway, I know we're on the same page with that. So again, it sounds like I think the bigger takeaway for people listening is there are these compounds out there that, you know, start with the basics first. I always want to see where people are with the basics to know how well they're doing. Like if you're eating well, you know, optimizing your protein, eating a lot of plants for the gut microbiome diversity, getting in healthy fats, eliminating seed oils, well hydrating, Exercising, doing your movement, doing your resistance training, doing your hit, getting your good sleep, you know, doing something for stress management, having great relationships, all the things. And then, you know, repleting any micronutrient deficiencies.

Next step up sounds like, okay, let's look at what peptides for where you're not really going, you know, where you're struggling. Right. And then that would be working with someone who is an expert in these. Yes. And that's going to be the biggest challenge is finding the expert. sounds like you are focused on really becoming that expert. So that's great. That's what I do.

Yep. Yeah. So because there's a gazillion of them and you could get yourself completely overwhelmed and spend a whole lot of money and not get to where you want to be. So that would be the next step in this. What about, you know, you mentioned you really had done a deep dive. And I feel like we kind of are with weight where we've been with cholesterol. Like, I remember back in the day, everyone was focused first on total cholesterol numbers.

Yep. Which we now know, it's like, well, that's dumb. And then it was LDL and HGL and good and bad. And then we knew that wasn't right. And then we were like, well, it's the size and the fractions. And then it was like, well, no, maybe it's LPL.A. Well, wait, it's able to be. Or it's like, well, is it placking?

So there's all this stuff. And I look at it very similar to weight going, you can't have someone step on a scale and make any kind of clinical decision. You have to know what the weights made up of. You need to know where they're fats located. You need to know how much skeletal muscle mass they are. To me, cholesterol is the same. Yes. It's like cholesterol is this stupid story that we can't seem to get away from.

When you're looking at heart health, how do you look at it? Okay. So you brought up some really good points. I always look at all of the numbers just to get a gauge. So when you go to the doctor and you get a metabolic panel or a cholesterol, panel, whatever they want to call it, you're going to get some basic test. You're going to get LDL, HDL, Total cholesterol, and triglycerides. Those are the four that you're guaranteed that you're going to get. You might get a couple like different ratios and things, but those are the four you're

going to get. Those are fine. I want that data, but that doesn't tell me anywhere near what I need to know. I need to get a comprehensive, some will call it like cardio IQ panel. It's just a comprehensive cholesterol panel is all it is. I literally just had my checkup today. I literally just had my checkup today. this morning virtually, because I have a doctor out of state who's the best in the United States that I go to, and I can explain my condition and why I go to him, but he's in Connecticut, so I have to do it virtual. And literally today was my checkup. We went through all my panels and everything, and I'll get into the medicines I take as

opposed to a ridiculous statin, but I'll also talk about that too. But the main function that he looks at when it comes to cardiac risk is APOB. Now, I've taken a deeper dive into LP L.A because that's the condition that I found myself to have, and there's not nearly as much data on it as there is on other aspects. So that's where I have put the majority of my specific time. But ApoB is going to be the one that gets a lot of the most look. it plays a really crucial role in your lipid metabolism and your cardiovascular health. So let me, I want to try to make this as easy as I can and not get to so people can understand.

So APOB is just basically a component of lipoproteins. And these are the particles that are going to carry fats like cholesterol and triglycerides in your bloodstream. So it's, it's really, it's essential for the recognition and binding. of lipoproteins to your LDL receptors on the surface of your cells, and that allows them to deliver lipids into cells for energy or storage. So that's what it is. Now, elevated levels of APOB are going to be associated with an increased risk of cardiovascular disease, and what generally is going to happen is that's going to contribute to the formation

of plaque, atherosclerosis, essentially. And they're going to be elevated when you have, like, hyper cholesterolemia, hyperlipedemia, things like this. And, you know, some people, it can be caused by a multitude of things. Genetics play a role. Your diet plays a role. Your lack of exercise. You know, what you're doing plays a big role in that.

There's some things that can certainly be helped and some things that you just kind of, you know, you've got the bad, the bad cards in the deck. But you can certainly control a lot of this by your own actions. Now, the L.P. Little A is a completely different story because you can't control that with your diet. You can't control that with your exercise. This is a genetic thing that's an inherited problem. And it's, I would say it's a far less understood problem. I mean, there are plenty of people that have an understanding, but I'm going to tell you a story after I get into like L.P. Little A with you.

it's lipoprotein little A basically. And nobody really tests for it. And one of the problems with it is that when you get this test, like for instance, when I went in and I told them I wanted this test, they tell you that, oh, you're only going to test this once.

You never test it again. And it is what it is. I just did not accept that. To me, that is nonsense garbage. And I never accepted it. And I've proven with my score dropping 250 points that you can make some adjustments and fix this.

So don't let somebody tell you that you can't, first of all. But that is the running school of thought. This is a test. You test once. It's genetic. Yeah. Just seeing if it's higher, not if it's higher, you're at greater risk.

Yeah. Nothing that you can do to lower it. No. Marker. No. And that's, that couldn't be further from the truth. Just like they tell you,

you can't reverse plaque in your arteries, which I can tell you I have spoken with and seen firsthand that you most certainly can. And I've spoken with some of the most, intellectual doctors in the world that will confirm that you most certainly can. So I don't buy when they tell you you can't. I'm not a take, I don't take no for an ant,

you know what I mean? Like I don't operate that way. I will find a way. And so basically, like I said, the LP little A is completely different. Now, you know this.

I know this. A lot of people know this. You go in there, you have any sort of elevation or anything. The immediate thing has put you on a statin. I don't care if you're like, like this a scoche over the mark. That's what they want.

Now, let's talk about a statin here in terms of what it will do. So you take a statin with an LP little A, which is what they tried to tell me to do. That will increase your LP little A number, first of all. Second of all, if you go get a calcium score, it will increase your calcium score on the amount of gauged plaque. Now, it's hardening your soft plaque, which is a good thing, but it's still increasing the score.

and it's causing a slew of side effects as we know and if you really sift through the studies and analyze them and understand them the rate of like cardiac occurrence is like 0.1% difference on what it'll actually do to help you and I've seen far more people still have occurrences while taking it muscle like pain constant you know liver problems elevated ALT AST and other numbers I mean I could go down the list so of course they put me on that that. And I get in the car with my mom and my wife and drive four hours to the Mayo Clinic, supposedly the best doctors in the United States in Minneapolis, where it's the highest rated Mayo Clinic. And I went up there with the idea of, hey, I want to take PCSK9 inhibitors. I don't want to take a statin. I want to address the LP Little A, which I found myself. And they told me it would be bad practice to put me on that. There was not enough data on L.P. Little A and basically, oh, you're fine. You're in great health.

You're in great condition. You eat great. You work out. There's no problem. My calcium score came back 141, and I had a CT Angio that showed I had 30-some percent blockage in the specific. And you were how old? 42.

Yeah. And I'm telling you, I mean, I train, you don't want to know how I train and how I don't, I don't drink, I don't do anything. Right. I live the life of what. I coach. Did you have a family history here of this? That's what I found. My dad had a heart attack at 59. My mom has no LP little A score at all. So I started to do some digging. Here's what happened. I started to work for a doctor. This is a doctor that cut a bad video on a steroid video I did.

So I called him and I said, hey, I think you got this wrong. Anyway, we got to talk and he said, I want to hire you. And he said, all of my workers, I have them go do a calcium score. He said, I'm sure you're fine. Just go do it. I said, okay, I'll do it. I went and did it, and my score came back. It was 140. And I went and do a panic.

Now, give people who are listening where, you know, you want zero. Yes. Which I did not. Yeah. And that's what the goal is. And what's the range so people understand. Well, I mean, she's, I've seen people with scores in the thousand. I mean, you, when you start getting above like 50, so basically this is, it's an assessment.

it's gauging an estimated amount of plaque that is built up in your arteries. And it's kind of giving you the locations. And of course, mine was near my LAD, which is the worst spot you can get. It's called the Widow Maker because it kills you. Like for most people, if you have an event and no one's around, you're not going to make it. I mean, chances are slim. And that's 50% of people, the first time they find out they have heart disease is they keel over and die. Yep.

That's right. And you know why? Because they're not checking any of these other tests. They're not. they go in and get a stress test that tells you nothing or they'll do even an EKG is only measuring your heart rhythms it's not telling you anything about anything else so you like you could go in with a perfect echo echocardiogram a perfect EKG all of this and have issues and never know it if you don't go through this rigorous process of understanding so when I found that I had the calcium

score I immediately started to dig and thought like what the like how how how And then I started learning about the blood test, the comprehensive blood tests. And I went and ordered them all myself at Quest. I did it all myself. I did everything myself because nobody knows. Clearly there's a complete negligence on this aspect of health. And there's numerous others. And then I got my LP little A score was 3.30.

So I immediately knew, okay, your LP little A score in the measurements I had maximum 75 and that's where you're getting into the yellow stage. over 100 and over 100 you're in the red zone. And so then I found that PCSK-9 inhibitors were the only things that would possibly help this. They have about a 25 to 30 percent ability to help you. And then I was coached on niacin being something great for it. And then as opposed to taking a statin, I was looking at red yeast rice, which is a natural statin. Now red yeast rice can have a lot.

lot of side effects and I stopped taking it. You still have to do. If you're doing that, you still have to do all the mitochondrial sport like K-10 and GG because you're still going to have the problems. Yep. You know, it's like people don't understand the drugs came from somewhere. Yes. The good thing about Vespa, which is one of the ones I was taken is that is just like the Pyrrospom official that it's like all natural and that is just shown. And then I take Rapatha twice a month. It's just a simple injection. It's a very quick one. And, I just got my LP little A score recently, and I, mind you, I was at 3.30, and they tell you it's not going to go anywhere. And my last score was 96. So I'm taking a clearly test in probably June, because I have to go out of state to do it. And that's going to give you an accurate assessment of how much soft and hard plaque that I have in my arteries. And I'll see if there's been any regression since I started doing everything I'm doing. So for instance, pomegranate juice was one of the things that can reverse. plaque. And then I'm taking uralithin A, which I...

I just say, so is the pomegranate juice, is it the uralithin A that's reversing the plaque? That's my hope. And yeah. Yeah, let's shout out to might appear with this. So oh yeah. Pomegranate juice can create a like help with a postbiotic uralithin A. So it's one of the things some people, and probably genetically you're one of those people that just does not make uralithin A. So pomegranate juice, walnuts, raspberries, can 40% of people apparently actually do this well. I'm not one of them. So I take, and by the way, even if you did it well,

who's having that much pomegranate juice? No, no, no, no. Right? Or it's raspberries, walnuts, some other stuff. But I was like, none of this stuff am I eating that much of anyway to make sure that I'm actually getting this. So, you know, there's so much data now on uralithinae and what it can do. It makes a ton of sense, but I didn't know that it did.

this piece too yes which is great for my my um husband's dad died of a heart attack in his early 50s and he'd had like open heart surgery in his 40s and tim had an elevated apobie so i was like on it i've been on it you know it's like right so my hope is because i'm doing a thousand milligrams now of might appear yeah so are we yeah everybody listening might appear is just the purest form of uralithinae that you can get in timeline nutrition makes might appear. Me and JJ stand firmly behind them because we've seen and we know and the data speaks for itself. I used it for a year.

Actually, probably two years before I started working with them and I just was obsessed with it. Like there's a few things that, creatine, qualia NED plus, things that you take and you're like, whoa, qualia synolytic, that's another one. Like things that you take and you're like, okay, I actually can tell you. tell a difference from this. Do not take it away from me. So, and it's interesting over the years, Dylan, I used to take a ton of supplements. I don't take as many supplements now. D&K, fish oil, magnesium. But I do take Cynalytics, NAD plus, might appear those are what I'm doing.

I'm spending more time on these types of things. And creatine, of course, like, you know, creatine, I think everybody should be on. It should be in water. Anyhow. All right. So we're going to see then from the clearly, this is a fun experiment because you're proving everybody wrong. Yes. On this, which it makes sense that you should be able to do this.

It does. You know? I am on a mission to show in the most positive manner just how far off a lot of these people are and to show people there's hope and to teach them how to do. it without completely eradicating their health. Yeah. You know, they, they rob Peter to pay Paul with a lot of these drugs that they make you take and they might fix one thing but cause 10 other problems so they can put you on something else to create more problems to fix one.

Right. It never ends. Well, it's not, it's not root cause medicine, as we all talk about. Wow. I think the worst defender of all is cancer drugs. Like, you know, I watch that just kill my dad. I went, Dad, you know the statistics for these drugs you're putting on and not. taking the drugs the statistics are actually the same right just one you have great quality of life

and one your life sucks from all the side effects but wouldn't listen to me so no i'm with you a hundred percent and you know that's the sad thing and but one of the things i've learned in all of my cellular learning is that everything you know originates in your cells and the degrading of your cells your cell membranes and your mitochondria that's where all the diseases are originating from and that's why if we can address that, get those fixed, get those repair, start that mitophagy process. That is going to mitigate and eliminate diseases from starting and forming, which is going to allow you to live longer and or a better quality of life, and you're going to age slower. I just wish there was an easier way. Like it just feels like the challenge there is that for most people that they don't

understand that. When you say, you know, your mitochondrial health and mitopathy and And it would be so cool if there was a way you could actually measure these things. You could measure your zombie cells. You could measure your. And I know me screen the thing that Hemel, yeah, they did that one. But I just feel like it's still early. Like, wouldn't it be great if we really could assess your mitochondrial health? So I don't want to speak out of turn because this is fresh stuff that I just learned, but we're measuring.

I got a big grin over there. Because I just learned this in class. a couple weeks ago. So we were looking at redox balance and going through. What does that mean? Okay. So redox, and I'm going to read this because I don't want to speak out of turn. Redox oxidation, that's the heart of cellular energy production. So this involves the exchange of electrons between molecules influencing overall cell health cell health and function. And so like, okay, for instance, what's the role of redox in aging and disease? And right off the bat, we're looking at NAD plus and NADH.

And these two are going to regulate metabolism, DNA repair, and cellular resilience. So when aging and redox decline, and this happens as we age, your NAD plus levels are dropping, right? And so that's going to be a cause of impairing your mitochondrial function. And so that's going to lead to oxidative stress. Now, one thing I can tell you without looking at anything is when we were learning about oxidative stress is how bad it is, but you do need some. There needs to be a little bit of oxidative stress. It's when it starts to become too much.

It becomes a problem. But if you totally eliminate it too, then there's also a problem. So chronic everything in our bodies. Right. Exactly. So here. Breakup, build down, break up, build down all the way through. And that's like with a lot of guys when they're doing.

steroid cycles, for example, and they get elevated estrogen, but then they take aromatase inhibitors and crush it. And then there's a big problem, too. So there's a fine line, right? So you're right. It's with everything. Now, here, redox imbalance and disease. Chronic redox dysregulation contributes to conditions like cardiovascular disease, neurodegeneration, and diabetes. So there you have it. But we were discussing in here different tests that we could take to look at redox balance and glutathione is a big one here because we were talking about that being a master antioxidant. And glutathione's another one, you know, and you could go get glutathione injections. I'm big on glutathione and vitamin B12 injections if you're going to go do those things.

Some of those places, they put too much in their cocktails and they're throwing so many different things at you. But, you know, there are things that are good and glutathione would be one of them. But you can over antioxidant yourself too, like with anything else. And you don't want to do that either. You know, it's funny though. So what is your thought on NAD, shots, IVs, patches, or supplements? I'm hit and miss. That's what I want you to listen to when I talk to Dr.

Yearth about NAD because she's kind of gotten on that. I think it's important to be in balance. And I think it's obviously important if your NAD levels decline. Like we just said, you're going to run into problems. Well, they're going to decline with aging. Yeah. I have, you know, all my friends were going and doing IVs. And they're like, and I threw up.

And I thought, I was like, why are we doing? I'm like, I'm not doing that. Spending four hours getting an IV. Then I walk out dizzy and puking. But I have been taking Qualia's NAD plus now for a year. Great company. And Qualia is amazing. Great company.

Like the owners came over to my house after Grant got hit and kind of walked me through how they could help me with their neutropics. And they're just crazy brainiacs. But the guy, like, you know, Greg Kelly, who created. the Cynoletics because he saw that it was something he wanted and the company kind of did it to appease him and now it's their best selling product and it makes so much sense yes um but the nad plus like it's great like it increases blood levels of nade plus 67 percent the way they put this formula together so smart and it's oral i don't have to inject you know it's like there's a couple things i inject but i don't want to inject more things about it no like it's just i don't it's not i don't

enjoy it. You know, it's not fun. So it's another one you can feel. I'll touch on something you brought up earlier, though, with the peptides and the injections. You know, they are working feverishly right now on develop. And I sat in at A for M on a conference on this and they're really working on making more topicals, making them more efficient, making more capsules. You know how you said you used the BPC pills. I use a BPC TB 500 gel and I love it. It is so nice. And it's, and it's, it's, you know, nice and it it it oh and it's so nice to not have to inject it's more effective than the pills i don't i believe that i do firmly believe they're effective i've seen it i've used them but the gel to me is the most effective aside from we we know the shots the most effective but this is so close it really

is interesting yeah which company is that um there's there's a few that do it underground um pep i I mean, honestly, I know of all of these companies because that's been my world for so long, so I can always make recommendations. Peptide Pro is very, very good company. I do a lot of work with the owner there because they go an extra mile on what they do. So that's a really good one where you could get those gels and things like that. I can talk to you about it later too. That's good.

I've been using, have you heard of health Jevity? Yeah. Yeah. So I've been using their thymocin, thymocin A is it? What is it? It's the TB 500. And then I've been using their BPC 157 PEA mix. Just because I'm being a big baby about not having you.

I admit it. But the gel sounds like an interesting one. Oh, it's great. And they're peptic strong. Like I am obsessed with, they are using a product. from naredes that was developed, that's called Pepti Strong, that helps with muscle, totally noticed a difference with that. Oh, yeah.

I really think that the most important thing we can do, especially for women, especially for women who've, like, tried to lose weight their whole lives, which means they've just destroyed their body composition, is to try to pack on as much muscle as possible. I agree. You know, it's hard because I understand some people like to just look at the scale, scale. I've been that way. I've had eating problems, body dysmorphia, but let me tell you something. It's very common knowledge and sense to understand the more muscle you build, the more fat you're

dropping. So the scale might not reflect it, but your pants size will, your Daxascan will, and your quality of life and the way you feel and your blood work will. So I and which, and which matters. Yeah. Yeah. And, and, you know, having some tone and some muscle looks a hell a lot better than just being thin and skinny fat or whatever you want to call it it. It doesn't look good. I've looked at some videos I've done in the way I've looked when I've looked that way and I don't ever want to look like that again. So yeah, you want to have it. You don't need to, you're not going to, you and I talked about this on my podcast. If you gain two or three pounds of muscle and hold it in a year, you have done something. You really have. I know. So don't worry about getting big. It would be

Yeah, like an amazing accomplishment. Everyone would want to study you. You know. No. It's like I kill myself to try to hold on to everything that I've got. Yes. You know? So, and if I could add a pound or two a year, I'd be overjoyed at this point.

Like, I just want to make sure I'm not losing. Exactly. You know, one of the problems I always running with the steroid guys and the guys that I've coached that are like pro-bodybuilders that are training Mr. Olympia and things that guys that are running run in cycles or just the bros is that they, don't understand yo-yoing up and down. You take these steroids. You lose most of what you gain. You're getting a quick fix and there's no long-term benefit or residual there. In fact, more often than not, not only are you going to lose a lot of what you gained,

but then you're just totally degrading your health, whether it's, you know, your natural testosterone production all the way to your liver, kidneys, prostate, all of that. The risk is never worth the reward. and you're not, you may gain 15 pounds, but a lot of it's water weight or bad weight or sloppy weight. And you're going to lose it as soon as you come off. More often than not, you're going to lose the majority of that just based on you not being able to physiologically handle that kind of weight or keep it on because it was being used by something exogenous that you're taking. So there's, you know, like I said, if you gain two to three pounds and hold it and you continuously do that, you have really, really done. an accomplishment. Well, I mean, it's what you just said about men with muscle is the same with women losing weight.

You know, it's like they go, they starve, they lose weight, they lose 40% as muscle, then they come back, they gain weight, they gain mainly back fat. They go, they do it again, and you look at what happens over time, and you've just destroyed your body composition of metabolic health. So, you know, really muscles the way to build it all back. Yeah. So, all right. Well, so you mentioned you at a podcast.

I know that I was on it. We'll put it into the show notes, too, which we'll put at jjvurgeon.com forward slash Dylan, D.YL-A-N. Thank you. And it is, what is the name of your, I think it's Dylan Jamilly podcast, right? That's it. I keep it nice and simple. Yeah. And is your Instagram, Dylan Jameli?

You know, all my socials because, you know, I have TikTok. I have X, Facebook. They're all just at Dylan Jameli. I was blessed to be able to not have anybody steal my name at the time. And so it's very simple. I had to buy mine back. Oh, my gosh. I was not as aware of the terrible people out there.

Yeah. No, I know. I was way ahead of the curve on everything. And I got good people that taught me, don't ever leave your name on anything. Buy it immediately if you're going to do anything. So I did. Well, and you're not Joe, John Smith. No, no.

All right. Well, I appreciate you. Thank you for downloading all this and being also very authentic about your own journey. And, you know, I know that you've also got great peptide e-books, et cetera. So anything you can give us to link on over to, we will. And I look forward to seeing you wherever I'm going to see you next, because I know we're on kind of the same circuit now. Yes, 100%.

Be sure to join me next time for more tools, tips, and techniques you can incorporate into everyday life to ensure you look and feel great. are built to last. Check me out on Instagram, Facebook, and my website, JJVirgin.com, and make sure to follow my podcast at subscribe to jj.com so you don't miss a single episode. And hey, if you're loving what you hear, don't forget to leave a review. Your reviews make a big difference in helping me reach more incredible women just like you to spread the word about aging powerfully after 40. Thanks for tuning in, and I'll catch you on the next. next episode. Want to listen to this show ad-free? Head over to subscribe to jj.com and start your

ad-free experience today. Hey, JJ here. And just a reminder that the Well Beyond 40 podcast offers health, wellness, fitness, and nutritional information. That's designed for educational and entertainment purposes only. You should not rely on this information as a substitute for, nor does it replace professional medical advice, diagnosis, or treatment. If you have any concerns or questions about your health, you should always consult with a physician or other health care professional. Make sure that you do not disregard, avoid or delay obtaining medical or health-related advice from your health care professional because of something you may have heard on the show or read in our show notes. The use of any information provided on this show is so long.