The Dylan Gemelli Podcast - Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, ...

Starting point is 00:00:16 Today's episode is sponsored by Apollo Neuro. Apollo is the leading doctor recommended wearable technology. Apollo's award-winning smart vibes AI works effortlessly behind the scenes, automatically integrating into your life to deliver gentle, personalized vibrations that activate your vagus nerve, helping you fall asleep faster, stay asleep longer, and wake up balanced, focused, and ready each day. Not only that, but the Apollo Neuro is the first and only wearable that improves your HRV. Apollo is effortless. Simply wear it throughout the day and night and let it do the work

Starting point is 00:00:52 for you. It's safe for anyone and everyone with no side effects and is the only wearable that can be worn anywhere on your body. Optimal health requires both the mind and body to be in line and Apollo is the key to establishing that connection. Check the description below to save $90 with my special discount. Take control over your health today with Apollo Neuro. All right, Welcome back to the Dylan Jameli podcast. So I have been really looking forward to this podcast. You're going to tell very quickly as to why. And I'm going to do my best here.

Starting point is 00:01:28 I literally just got done telling my wife that you have so many titles after your name that I can't memorize all of these. I took notes and happened up here so I could do it. Everybody, this is Dr. Elizabeth Yerth. Welcome. Thank you, Dylan. Thank you for having me. Yes, yes, yes. She's an MD, and we can get into some of the other certifications, but I know that you're a double certified, double board certified physician.

Starting point is 00:02:00 That's physical medicine and rehabilitation and anti-aging regenerative medicine. So the credentials are endless, and I am just so excited to get all of the information I possibly can out of you to everybody and for my own benefit selfishly. So I want you. We were so lucky to have a chance to to work together at Olympia recently. And so Dylan and I got to kind of know each other a little bit better being on some panels together, Olympia. We both became very rapidly fond of each other. So it was so I'm honored to be here with you today. Thank you so much. You know, I had a meeting with Don at STEM Regen. And I hadn't actually met him yet. And the first thing he told me literally was. well, I did some research on you and I respected you immediately because Dr. Ureth was following you. I was like, okay, all right. So just real quick, everybody, as she said, I met her last year, not this Olympia last year, just very briefly.

Starting point is 00:03:08 And then I had the honor of actually getting to sit next to her and speak, which may have been a little out of my league, but we started talking immediately, and I'm just so grateful and thankful for everything that you do and all of your teaching. So I'm going to exploit you a little bit today and get as much info as I can. Great. Let's go for it. All right. So one of the things that you talked about that I literally had no clue about that caught me off guard at the Olympia was this new form of oral testosterone. And, you know, being where I kind of come from, Andrea all and everything on the forums was people were talking about that. And I was always like, eh, it's not so great. And so I'm intrigued. Tell us about this new form of oral testosterone and, and some of the

Starting point is 00:03:53 facts behind it and where you kind of see it going in the future. Yeah. So, you know, you and I come to that same school where no, oral testosterone is bad, right? Because it's toxic to the liver. So you get liver damage. And so we always taught everybody to stay away from it. And, and so when this, this came out, which was pretty recently by a company called Marius Pharmaceuticals, it was a little surprising. We're all like, okay, you can't do oral testosterone. But what they did is they devised an oil testosterone that was not processed by the liver. So it actually goes through the gut. It gets absorbed directly through the lymphatic system in the gut, bypasses any type of liver metabolism. So there's zero toxicity to the liver. And so it's extremely safe. No change in liver. And so it's extremely safe.

Starting point is 00:04:42 liver functions, they followed people for quite some time, they went through a large safety profile on it. So it's an FDA-approved drug and zero liver toxicity, no changes in liver metabolism. So they decided not to kind of go the traditional pharmaceutical route. So what they did is they're working primarily with compounding pharmaceutical companies, and they're selling it to the compounding pharmaceuticals. because if you look at where most of us who are doing hormonal medicine and what you recommend to a lot of your clients, we're working with compounding pharmacies a lot, right? And so their feeling was that was going to be a better place to educate people, was through the compounding pharmacies.

Starting point is 00:05:22 And so they will sell it to the compounding pharmacies, the compounding pharmacies will then sell it to the physicians. So a little bit different way, you can't just go to your regular pharmacy and get this drug. It has to go through a physician that knows about it, knows working with compounding pharmacies, which on the downside is probably going to be most of your doctors who are traditional medicine doctors are not going to know about this drug and not going to utilize this drug. But if you really look at how many traditional medicine doctors are even doing much for hormone replacement, even though they should be, it is very few. So, yeah, maybe if you're completely bottomed out to zero on testosterone, they might treat you.

Starting point is 00:05:58 But for most of the, most parts, they're not the doctors who are doing a lot of this. So this is a really nice new addition because a lot of, of guys, and there's nothing wrong with injections of testosterone, right? It works very well, but, you know, and you can do it twice a week, every once a week dosing, twice a week dosing, or even, you know, small, sort of smaller dosing even more frequently than that. So there's a lot of ways you can do testosterone, but a lot of guys don't like doing injections. So this is another option. A while ago, nasal spray testosterone came out as well. It was kind of a cool option, too, except that nobody liked it. When you did it,

Starting point is 00:06:35 it would drip out of your nose. It burned a lot. So it kind of rapidly fell out favor. But this is really well tolerated by people. It has a couple advantages over using injectable testosterone. So number one, when we do injectable testosterone, if you're a younger guy, you have to protect testicular function, right? Because you're going to reduce your own production of testosterone and potentially reduce

Starting point is 00:07:00 spramatogenesis and your own LH and FSAH drop. so you're going to actually get, you know, atrophy of the testicles and all the things that go along with that. So this does not do that. So very interestingly, when you do small dosing orally, it does not have the same detrimental effects on testicular function. So we're not seeing guys have to adjunct it with things like in chlomaphene or HCG who are trying to preserve fertility. And it also, because you docent twice a day, it has a very, very nice physiological. curves to what your normal testosterone surges are. Kind of surge up in the morning, they surge up in the evening.

Starting point is 00:07:38 So basically, you can keep this very nice physiological dosing. And guys seem to really like it. So what I've seen in my men who have been put on it is that they, who I've switched over from injectable to this, is that they're actually reporting a little bit better, you know, sex drive and erection quality and muscle building. So I think there may be something to that more physiologic dosing that is actually going to be beneficial as well. What are the downsides?

Starting point is 00:08:04 Downside is cost. It's certainly more expensive than doing a subcube or intramuscular injection of testosterone. Even if you're dosing testosterone high, this is going to be a more expensive option for you. You know, with time, we'll come down in price, maybe. But, you know, it ends up being really probably about $100 a month. So definitely more expensive than traditional testosterone, but not out of reach for a lot of people. And, you know, I certainly have a lot of guys who have really found it just better, simpler, and they're happier with the outcomes up.

Starting point is 00:08:39 I would pay $100 a month and not have to inject anymore. That's not my injections. Yeah. I think there's a lot of guys who will, yeah. And especially if you're like you, you know, younger guys, you know, as you get older, maybe the preservation of testicular that function isn't as important, but certainly in our younger population, that is important. And it's always a little bit of a, you know, when do you start testosterone? because I have 25-year-olds who have low testosterone.

Starting point is 00:09:01 They need treatment. But I'd be very cautious with my 25-year-olds that I'm protecting spermatogenesis, right? Marius Pharmaceuticals who makes the chisetrics is just doing a really long-term study on spermatogenesis. The early studies to get all the authorizations showed no effect on spermatogenesis, they're now doing a much longer-term study to see if that pans out. But it looks like it's going to. It looks like we're going to not see that effect, so it's not going to affect fertility for men. I'm in a reserve saying that's 100%, but we'll follow it.

Starting point is 00:09:29 We can follow that very easily on the other men. And I think if you look at the effect on LH and FSAH, it should not. We're not seeing that same effect that I see with testosterone. You know, I'm, you know, as a female, so they make it right now a dosing. So typically it's anywhere from 200 milligrams twice a day to 400 milligrams twice a day. So it depends on, you know, how much testosterone you need. So it's a high dose for women. But one of the things I'm having some women do who want to try it.

Starting point is 00:09:56 is actually freeze the capsules and then cut them. Because once they're frozen, they're a gel cap, basically, because testosterone's an oil base, right? So they're a gel cap and then cut the capsule and try it in a smaller dose for women. Because it's a nice option for women, particularly because it does have a little more rapid act. And for women, put it for things like libido, where, you know, that seems to be a problem for a lot of women. You can actually get a little bit more of a direct effect. So if you do it in the evening, you can get a little bit more direct effect to help a libido too. So we're kind of experimenting with that with women right now.

Starting point is 00:10:26 They will hopefully eventually come out with some female dosing on it. That would be nice, but they're hitting the male market first. Right. I've got a few questions to get into it. The first question, so let's just use an example. Let's say that your normal injectable dose is 150 milligrams a week. What does that equate to for you to take this pill daily? It's probably going to be, so 150 to 200 milligrams.

Starting point is 00:10:51 It's probably going to be about 400 milligrams twice a week. although I have been able on some guys 100 to 150 get away with the 200 milligram twice a day dosing as well. So 200 milligram twice a day dosing if you're in that 100 to 150 range, if you're more up closer to the 200 a weekly range, then probably going to have to get up to more of a 400 twice a day dosing. And then so to get the same levels. Okay, okay, okay. And then so let's say somebody like me that's been on TRT now for roughly about 10 years because I started like in my early 30s, like an idiot. it doing it myself, but that's beside the point. Obviously, my LH and FSAH is bottomed out.

Starting point is 00:11:30 Now, let's say that I switch over. Would those numbers come up or would they stay just like they are? Yeah, it's hard to say. I think in the younger population, and we don't have enough long-term experience yet to say for men who have been suppressed for a long time, are we going to see them now start to improve testicular function? Don't know the answer to that. I would say in a couple of my younger guys who had suppressed LH and FSHs, but I'm talking about my 20, 30-year-olds,

Starting point is 00:12:00 and I've switched them over to the oral form that they have had improvements in their LH and FSAH. Is that going to happen to you? You know, who's been on now for, you know, how old are you? Forte two. Yeah, 42. So 42 are you going to be able to recover? If 42 is still young, would be interesting to see. I think that's where our experience and more and more doctors using this.

Starting point is 00:12:19 There are so few doctors right now who are even aware of this drug, right? I mean, you, you're in this business and you haven't heard about it, right? No. So it's pretty, you know, it's still has a long way to go in terms of educating, educating people. But they're, you know, I know Ali's doing her Silverback Summit coming up. I know they're going to be there. I think, you know, so they're trying to get out there now and get a little bit more recognition. So I think we'll start seeing them growing.

Starting point is 00:12:44 Then we'll have more data. We'll have more. Wow, I am seeing my patience actually reverse on this, right? I've only been using this now for, you know, a few months because it's really only been available that long. And so I think this is going to be a fun new sort of venture, and we can follow. You and I talk six months from now, we'll have a lot more data to put together. But I think it's, you know, it's such a nice new option for people because you're right. I have a lot of guys who do not want to deal with injections, especially if you're traveling

Starting point is 00:13:10 or things like that, right, and you're having to travel with needles. You know, I have guys who are traveling a lot, you know, and they're on, you know, planes going overseas and things like that. And, you know, they're gone for a month at a time and they're having to travel with their needles and their injectable vials of testosterone, it's just a little bit of a hassle, right? It is. This is going to be a whole lot easier. It just gets annoying.

Starting point is 00:13:31 I mean, when you've been doing it forever, it's not like it hurts. Yeah, it doesn't hurt. It's not this. It's not that. It's just tedious, right? Yeah. I do tons of peptide injections, and it's just tedious. And I fall off the wagon because it's just tedious, right?

Starting point is 00:13:44 Yeah. And so anything that we can make easier in our lives is certainly going to be a welcome change. Yes. It's like I get up and everything's in my kitchen in the cupboard there. And it's like I got to shut the window and da da da da da da and like this morning. I bled a little bit and it got on the floor just stupid, you know, whatever. And my wife's like, what's that on the floor? And I'm just looking at her like, fuck, I don't know, you know.

Starting point is 00:14:09 And then I realize. Oh, yeah. Here's another question for you about that. So I know that most people don't really have estrogen trouble on TRT. but like for me, if I go over 200 milligrams of test, I start to get estrogen conversion. How is the estrogen conversion on this? Would it be similar or is it worked? Seems to be much less.

Starting point is 00:14:30 We've seen much less aromatization to estrogen as well with the oral. Just as it's going through the lymphatic system, because that has to do with the metabolism of the testosterone, right? When you're going directly into the lymphatics, we're not seeing that aromatization. So much less. So it's one of the groups I've switched over are my guys who I really have trouble controlling estrogen conversion. It seems to be a much better option for those guys. So I think that that's going to be, again, will we see some guys still convert? Maybe, I don't know.

Starting point is 00:14:59 Again, don't have enough experience with it yet. But just if you look at the mechanism of why testosterone aromatizes, you should see less of it with this lymphatic version. That's what I was hoping to hear. That's excellent. So I think this is going to be, I mean, honestly, this is going to be really, you know, a game changer in our world. you know, we'll see. I don't, I don't know if you're going to get up to, like, you know, our bodybuilders who are doing, but, you know, really super high, super physiologic doses. Maybe you can't dose to that, to that level with an oral form. Don't know.

Starting point is 00:15:33 But I think that, you know, from most of us, this is going to be where you can get a good, really nice, high physiologic level of testosterone. And, and, again, I think that dual cycling, that getting a little bit in the morning, getting a little bit in the afternoon, You know, when we do injections, even if you're doing like a twice-week injection, you still get this like peak drop, peak drop, right? So, you know, you're super high. If you test your testosterone right after you've injected it, it's going to show up really high in your blood test, right? If you test it, you know, the day before you do your injection, it's going to be really low or, you know, somewhat low. You know, so if we can keep this a little bit more of this, which is what testosterone normally does,

Starting point is 00:16:08 it should be, that should be better for our body. It should be better for our brains. It should be better for muscle ability because it's really how the body was designed to do it. Yes, this is, I swear to you, I was looking at you and I was like when you were talking about it at the Mr. Olympian, I'm excuse me, I was trying to not look like a dipship because I'm just staring at you like what, you know, like. Yeah, but you're right. I'm out of my field, I would say one out of every hundred of doctors who are doing, you know, true functional hormone medicine, know about it yet. So these guys are trying to get out there. They're trying to promote it.

Starting point is 00:16:39 We're trying to help them. We're trying to, you know, get word out because it's, I think it's such a nice option for people. For me, I'm excited as a woman. I'm excited for some female dosing on it, honestly. Because I think the same thing with women. I think with women, the problem is, you know, again, we don't, you get these super high levels, if you're doing injections, right? These super high levels that come down.

Starting point is 00:17:00 Or people who are doing pellets, the same thing. You put a pellet in, your levels are super high for a while, and they drop down, right? Yeah. So you get this super physiologic levels for a while just to maintain a nice normal level for some period of time. And, you know, then you're going to potentially get some of the side effects associated it with these high levels, you know, just so that you can, at most of the time, be at a normal level. So if you can avoid that, I think we're going to see less problems with women with acne and hair loss

Starting point is 00:17:22 and things like that by using these kind of these kind of more smaller doses in a physiologic fashion. So I'm excited for them to come around. I don't know when they're going to start working on. It's too bad. You know, too bad that women always get a little bit thrown into the downside. But I am going to try, even myself, I'm going to try playing with cutting, you know, the little capsule in half. I thought it might screw up the absorption, but I talked to them, the scientific advisor just recently and he said no it doesn't matter it's not the capsule that's causing the absorption it's the oil base that it's in itself that's affecting absorbs and so you can sit very safely you couldn't do that with a slow release medication because the capsule's too important if you

Starting point is 00:17:57 cut it you screw that up yeah this is not the same and it doesn't change the the way it's absorbed by cutting it so that's an option it's even an option if guys want to save money potentially you could you know if you can go with a lower dose you could buy the higher dose capsule and then you know So what was the name of this again? And what was the drug company that was making it? The drug company is called Marius M-A-R-I-U-S pharmaceuticals. And the drug is called Kizetrix, K-Y-Z-A-T-R-E-X. Excellent.

Starting point is 00:18:28 Okay, cool. And again, you can't go to your pharmacy. You can't have your doctor, right? You push your prescription for this and go into your pharmacy. They don't know what you are talking about, okay? So you're going to have to find a doctor who works with a compounding pharmacies. And I will tell you, there's not a lot of compounding. pharmacies that are using this either.

Starting point is 00:18:44 They've only, they've only, they're only right now working with a few compounding pharmacies. We, we work with New BioAge, who is working with Marius to distribute the product. So you have to find a pharmacy that also can get the product for you, and there's not a lot of pharmacies. So those of you who want it, who want to educate your doctor about it, new bio age and you, B-I-O-A-G-E, as a pharmacy that is working with Marius to get that product to your doctor, you know, for you. basically they can send the prescription to new bioage new bio age will send it to you this is and this is one of the reasons why i love these so much it's like so we're talking i had

Starting point is 00:19:22 some things like okay that i know i want to talk to you about but you've just brought me into something else that i don't think there's enough information on i think you would be well well versed on and i want to get this information out there for women that are looking well first of all what kind of symptoms does a woman have that may be a little different than a man in terms of low testosterone and what ages and what kind of things cause that in a woman because and some some people don't get it like and I get it from being in the bodybuilding world but if a man crushes their estrogen we got a we got a problem we got a big problem right and same with the women I know that estrogen's dominant in women and vice versa testosterone but I don't think people

Starting point is 00:20:07 truly grasp the concept of you still need some right Exactly. You know, obviously our proportion of estrogen testosterone is much different than you guys. But we absolutely need testosterone. And we need it for the exact same things guys do, right? We need it for libido. We need it for orgasm. We need it for muscle building. We need it for fat loss. And it gets so ignored in women. And it's sad. I mean, I, and for orthopedics. So my background's from orthopedic world. And I, you know, I put a lot of my orthopedic patients, if they're trying to heal a fracture or trying to heal an injury. And they have no androgens on board. They can't do. do it. And so it's very funny. I put recently a patient who was having surgery on some antibiotics actually just to help her heal from surgery. And of course, her doctor came back. It's like, what the hell? What, you know, what are you doing that for? And, you know, so for women, it gets really neglected. Nobody, even, you know, the gynecologists may look at progesterine and estrogen and women as they're getting menopausal, but not testosterone. And the problem with testosterone is it starts dropping very young. So when you look at women,

Starting point is 00:21:08 you know, usually progesterone starts dropping at a very young age, testosterone starts dropping a young age. Estrogen stays high pretty long, and that's why you get these women who start having that estrogen dominant body. They have that kind of big belly, big breasts, skinny little legs. You see them all over, right? I was at a Billy Joel Stevie Nix concert, so it was all people my age, right? And, you know, all these women had that exact body build, right? They all had like the little round, you know, belly, you know, boobs and no muscle. And, you know, and that's just this estrogen dominant state where you have no testosterone. You know, you have no progesterone so that you have to balance these hormones.

Starting point is 00:21:42 And as we age, it becomes even more critical because maintaining muscle is so critical to our overall longevity. You always say muscle is sort of our currency to life. And you have to have muscle to be able to do everything in this world. If you get sick, you know, and you don't have muscle mass, you're not going to do nearly as well. If you have an injury, you're not going to do nearly as well. So we have to maintain muscle.

Starting point is 00:22:04 It is absolutely impossible to maintain muscle. if you do not have testosterone, right? So I see these docs who are telling women to go exercise, and their testosterone levels are, you know, 0.003, you know, for free testosterone. I'm like, you can go exercise all you want. You might as well just throw yourself down the stairs because you're going to get real sore, but you're not going to build any muscle. And, you know, and so it's sad because these women are trying.

Starting point is 00:22:26 They're truly going to the gym. They're trying to exercise and they're trying to do everything right, eat right, and they're not losing fat and they're not putting on muscle. And that's because, you know, they're working with a detriment of having no testosterone. Yep. But let's look at the younger. women because that's a group that scares me a lot because if you look at what like birth control pills do and you know and you know almost 50% if not more of women are on birth control pills from a young

Starting point is 00:22:47 from a young age some even you know starting at 13 so you know when you look at that you know and sometimes that may be the best choice to prevent to prevent pregnancy obviously an unwanted pregnancy is also a very bad thing but but there are other options what women do need to realize if they are taking birth control pills is birth control pills raise something called sex hormone binding law which a lot of your listeners are aware of, but a lot of people aren't. And sex hormone binding lobin binds the testosterone, so it's not available to utilize for muscle building and all the things you need it for. And so what you'll see in these women is they have very, very high sex woman binding glibbean levels when they're on birth control pills. So they have no free testosterone, no available testosterone.

Starting point is 00:23:28 So they have trouble building muscle. They have more injuries. They get more depressed. They get more anxious. Remember testosterone, just like in men. But symptoms of low testosterone and men, lots of times that anxiety, depression, that sort of low grade, just feeling beaten down by the world. Same thing happens at women, too, right? You know, it's a little why men are always a little bit, you know, tend to be a little less anxious and a little less depressed than women oftentimes.

Starting point is 00:23:52 Is this, you know, testosterone is very protective of them until it drops. Well, same thing with us. So we have this very protective hormone that's telling us, you know, you can take on the world, you can fight against all this stuff. if I have no testosterone, I feel defeated, feel like I can't really do this stuff. Also, just like in men, helps with sleep, right? Testosterone, you know, if you think about guys fall asleep after sex, it's because it's a big surge in and antigens. Same thing with women. If you have more androgens at night, you're going to sleep better, you're going to have more, you know, you're going to have more restful sleep.

Starting point is 00:24:20 So, you know, so we don't, we always think about it for muscle building and maybe libido, but think about it for all the brain functions too. You know, depression, anxiety, sleep quality. Those are all really important. There's very few women. very few over the age of 40 who will have normal testosterone levels, you know. And I will tell you, because I have a lot of young patients as well, I would say at least half of my young females have low testosterone levels. So if you're on birth control pills, you may need to supplement with some testosterone, right? And again, the dosing on that is so

Starting point is 00:24:52 variable. You have to find the right dose, you know, and you have to look at how people are metabolizing so they don't get side effects from it. But it's so critical, you guys, to well-being. And, you know, I get sad when I look at these women in the gym who I see over and over and over again in the gym. And they're there and they're doing things. And they're actually lifting weights, you know, maybe not heavy enough, but they're not, you know, they have no strengths because they don't have any antigens, right? Yeah. So, you know, it's, you know, it's sort of the same symptoms as in men. It's just that men, they're protected a lot longer than we are, right?

Starting point is 00:25:25 The testosterone levels, well, I won't say anymore, but used to be testosterone levels didn't start dropping until men got a little bit older. So they were more protected for a longer period of time. And women, they start dropping quite young. I mean, our optimal testosterone levels are usually around, you know, 15 to 18, honestly. Right. So really young. You know, one of the things that I want to stress while I've got you here to people in general is when you go to a doctor, they really, their answer to everything is just a CBC and a CMP panel, if anything, right? They complete blood counts and metabolic profiles.

Starting point is 00:25:59 but they don't look at hormonal panels. They don't do comprehensive cholesterol testing. I found out some things about myself. Had I not been educated and working on the proper tests, you know. Exactly. Lucky I caught some of the things early, right? So I think it's important that people understand, look, there's plenty of resources out there that you can go get online or you can just tell your doctor, look, I want this shit check, you know.

Starting point is 00:26:26 You can even, you know, people don't realize you can order your own labs. Yes. You know, the only reason to go through a doctor for your own labs is if you want to run through insurance. But most labs are very inexpensive. And you can go to, you know, lab core, just order your own labs. If you're going to cash pay that, you don't need a doctor to order labs for you don't even realize that. You can very easily order your own lab panels and you just need to learn how to interpret them, which, you know, like you said, there's resources to do. We put together a whole course on this.

Starting point is 00:26:52 So we have this Human Optimization Academy, which if you guys go to BOI.com, we teach you how do you read your CBC? how do you read your CMP? How do you read a lipid panel? What lipid panel do you need to know? Right? You're right. It's not just your cholesterol. That means very little. So you have to know your hormone levels from a young age on. And yeah, and you know, you look at the traditional lab panel your doctor gets, which is a CBC, a CMP and a TSA maybe and a lipid, which is, you know, just your basic lipid. It's not very useful for longevity. It might tell you're not dying at that moment in time, but it's not very useful for anything else. Yeah, I mean, you check your LDL, your HDL, and your triglycerate's great, but you don't know your APOB, your LPLA, your particle size, the stuff that will really kill you. Exactly. Right. You know, I'm a fan of high cholesterol. We know the high cholesterol is associated with better brain quality, better muscle quality, but it has to be the right type of cholesterol. And that's not HDLs and LDLs.

Starting point is 00:27:46 It's APOB and APOA. Nobody tests it. You need to know what your APOB is. You need to know if you have an LPLA, if that's high, that's really critical to, you know, to work on modifications. So that's stuff that, you know, if your doctor's not doing and most doctors don't. I see people all the time who hand me their lab profiles. And I'm like, okay, this is useless to me. You know, I was working with Dr. O'Connor last year and he made me go get a calcium score.

Starting point is 00:28:10 And he said, it's probably going to be zero. You know, you do everything perfect. And I went in there and my score was 120. And so I start to dig and I find out my LP little A was like 350. Wow. Yeah. Yes. And the guys for you guys don't know, an LPLLA is a genetically inherited thing. Diet won't change it. Exercise won't change it. You know, statin drugs won't change it. There's

Starting point is 00:28:33 nothing that will change the LPLA. You have to work on other modifications to try and make your blood, your cholesterol kind of stickier in a sense. Yeah. So basically heavier and stickier. And so unfortunately, you know, Dylan and you know, and my husband has a high LPLA, two of my kids do, you know, it's just a bad, unfortunate gene. In the future, we'll have gene modification therapies and things like that to get rid of. But for now, you have to know you have it, because as you said, it is a really big risk factor. And most people, it never gets tested. No. Had I not done that, I have a 30% blockage. And then they just statin this statin that. I went to the Mayo Clinic. And they told me, because I said, look, I want PCSK9 inhibitors.

Starting point is 00:29:13 I want Vespa. I want Repatha. And they looked me in the eye and told me that would be bad practice. The statin is the answer. And I told my mom and my wife and the. the car back home for three hours. What a waste of time that was that a statin has no bearing on LP little A. I knew more than they did about it. Right. Exactly. Yeah. And I'll see you the main reason is even that, you know, when Stanton drugs get rest, recommend it over PCSK inhibitors because PCSK inhibitors are much safer and much better drugs. It simply costs. It's because it's hard to, it's hard to get a PCSK authorized. Doctors to go through all these hoops to get pre-authorization for it. They're expensive.

Starting point is 00:29:52 So the protocol is put something in a statin drug. It's cheap. It's easy. You know, and then, and if they fail that, somebody may talk to you about a PCSK inhibitor, but it should be really a first line defense in somebody like you, right? Yes. I had to go through this process where they wanted this to be elevated, that to be down. And I'm like, that's impossible.

Starting point is 00:30:08 It can't be done. And that makes no sense because I'm hurting myself. Anyway, you know how it is when you know people. I got both, you know. And every year, it's a big. But most people aren't like you, right? So then what do you do, right? It's really hard.

Starting point is 00:30:24 And that's the case where PCSK and there sometimes are really hard to work with insurance on. And they're too expensive for any of us to afford. There are thousands of dollars a month, right? So you don't get insurance help on those. But there's work around. If you know, if your doctor knows how to work with the system, they can typically get them for you, right?

Starting point is 00:30:39 I just had that battle right now. My Vesipa renewal came up and they wanted to put me on the generic. I know one of the head people that produces it. And he said, no, the generic is missing X, Y, and Z. do it. And I just thought with them until they just, they gave it to me. Finally. Yeah. Yeah. Because, well, and I'm a different breed. I'm just not going to take fucking no for an answer. You know, that's what scares you is that, you know, 90% of the population is just relying on their doctor, what the doctor tells them. And, you know, unfortunately, then they're missing all these things.

Starting point is 00:31:11 And that's why you guys, God, you have to. You have to listen to Dill and you have to educate yourself. You've got to go learn because you can't get it from your doctor. I, you know, I'm sorry. I wish, you know, I keep thinking maybe medicine will catch up, maybe it'll be better. And I'm not going to say medicine has no bearing. It does. I mean, you know, there's, there's a lot of traditional medicine that's saving lives. So, you know, I'm a traditional medical doctor from training. But I will tell you, I don't do most of the things I learned in my traditional medical career because it's, it's not the right way to go. But don't, you know, this is a balance. You don't just say, you know, I'm, you know, I'm dying of a horrible

Starting point is 00:31:47 infection. You need antibiotics, right? Right. You poor. I mean, I even just recently I had to go through that where I went, I had, well, first of all, my liver values got elevated through the roof. And then I started to have, I found some problems in my urine when I got it tested. And then I got a rash out of nowhere. And I went to the ER and they told me, oh, you're fine. And I looked at her and I said, I'm not fine. No, I'm not fine.

Starting point is 00:32:13 And then I did. I had blood in my urine out of nowhere. That's fine. And they said, oh, I said, you know what, fuck this. I'm getting online. I went to my UTI.com, acted like I was my wife, got my own shit, and was fine in a week. I mean, that's what it's come to, where it's like, okay, people do think they're WebMD when they get online and go read a couple of things. I'm not advocating that at all.

Starting point is 00:32:38 But I am saying, be diligent because you know this. Learn. Yes. Yeah. General practitioner means general. They're not specialized really in anything. somebody like you is a specialist. Like that's what I seek out, especially for a problem, you know.

Starting point is 00:32:54 But even if you went to your specialist urologist, for instance, or, you know, your specialist endocrinologist with you because you feel crappy and your thyroid hormones, you know, and they test the TSAH and they go, no, your thyroid looks fine. And you're like, God, I really feel like my hair is falling out and I'm freezing cold all the time. And I'm really sluggish. I sure my thyroid's fine. And then you go and you do a full thyroid panel on that person where you look at a TSA, a free T3, a thyroid antibody, and you realize they've got thyroid antibodies, they've got

Starting point is 00:33:22 a high thyroid globular, they, you know, they have a low free T3. And you're like, no, your thyroid is not fine. A TSA was just not enough to find the problem, right? Your traditional medicine doctor does not do that. Even your endocrinologist doesn't do that most of the time. So even a specialist, unfortunately, you guys are going to have to, I hate to say it, but you have to do some education for yourself and you have to. And then you have to find a doctor who will work with you, right? So even if your doctor doesn't know it, you know, if your doctor, you try and talk to them about something, they'll go, no, that's just not the way it is. And they won't discuss it with you, then find a new doctor. I have people teach me things all the time. You know, I have people who argue with me about things. And if they can prove their point and convince me that they're right and I'm wrong, great. You know, I love that. Bring me the evidence and I'm willing to read it. But you should have a doctor who's willing to talk to that stuff about you. So you have to find, even if it's a traditional doctor, somebody who's willing to say, yeah, I don't know about that. But, you know, if you know about that, let me, let me read the research, you know. Exactly.

Starting point is 00:34:21 That's the thing. If you feel uncomfortable or if you don't, if something just seems off, it's not like you just, there's one doctor in existence. Just go find somebody else. Right. Right. Right. Yeah. Exactly.

Starting point is 00:34:33 Okay. So I want to shift gears a little bit here because you know kind of my background is more like research chemicals, peptide SARMs and then hormones, which we already talked about. So I told you this when we were talking before that I was like, I don't, I didn't know people like you even existed. I just figured that like my whole realm is all of these bros I have to deal with and all this bullshit. And when I started studying peptides, it was 2011. They had just kind of research chemicals were just kind of a new thing. You know, nobody talked about them. Nobody knew what SARMs or peptides were at all. And there were shit.

Starting point is 00:35:12 I bet you there was maybe 10 peptides to choose from on a site. And it was your GHRPs, your Ipomerellin and CJC 1295. And that was about it. I mean, there was really. Yeah, there was. Yeah. Yeah. Yes.

Starting point is 00:35:26 Sarmswise, there was two. It was 2 866 and S4. And then two sites at MK 677. It was like $400 a bottle. Nobody bought it. It was just way out of reach. And nobody understood it. Right.

Starting point is 00:35:38 So all you knew is, you got a ton of water retention from it when you first started. And that was about it. You know, so tell me, first I want to start off with this. When did for you, especially, when did you kind of realize just how wonderful peptides were? And when do you feel like it started to break out more mainstream, I guess, or get more popular? So like for me, with SARMs, when they got popular was when pro hormones got banned. and all of the people selling pro hormones freaked out like what are we going to do and then

Starting point is 00:36:14 they started you know shift into arms right so what do you think caused the peptides to break through and when did it kind of hit for you like whoa like we got something here well you know it's it's kind of interesting because you know you you kind of come from this sort of bodybuilding world um you know in the bro science world and it's it's really where hormones i remember when i first started learning about hormones the bro science had more than the regular science did on, right? You kind of go to, oh, okay, well, they, they can give, the regular science can kind of give me some of the stuff, but the bro science people were figuring out how to use these in an effective fashion. You know, what could you do? What were the side effects? How can you

Starting point is 00:36:49 push these? So, so, you know, it was very interesting this bridge between science and bro science, because the bro science people were practically putting this stuff into action and seeing what happened, right? They were doing the end-of-one experiments and saying, well, if you take too much of this, this, this bad thing happens. But you can take a lot of this. And so, you know, so the same thing started happening with peptides. I, you know, I think one of the world experts really on peptides is William Seeds. If you guys who don't know it, he wrote a great book called the peptide handbook. It's a really good, if you guys want just a basic education on peptides, it's just a really good, probably have it here. Oh yeah, peptide protocols. This is a great book

Starting point is 00:37:26 by Bill Seats, and it just gives you all different peptides and sort of how to use them. But Bill came from orthopedic background like I did, and I met Bill actually kind of through more of an outside realm, but started hurting him. This was probably now, seven years ago or so, he was actually sort of making his own peptides, and he was using him kind of in his orthopedic population of patients. And I thought, oh, wow, because I came from this orthopedic background where you, you know, it's a little bit of, you know, somebody, you know, hurts their knee, and then you stick steroids in it, you put steroids in it, and then finally you, you know, do surgery, and then you replace it. And, you know, it's sort of a stupid field. We never,

Starting point is 00:38:06 really fixed anything, you just kept sort of patching people together until something was replaced, and then you do it for the next joint, the next joint, and next joint. And now what we know so much more is that, you know, these orthopedic injuries, degenerative joint disease is really a disease. And we can do so much modifying that disease using things like peptides that we never had the option before. So when I met Bill and he was doing this, I thought, oh my gosh, I'm going to bring this into my orthopedic practice. I will start helping people heal better using these things. And so I started dabbling it more within the, you know, the musculoskeletal world, even things like nandrolone. I mean, I was using nandrolone primarily, you know, you think about in the bodybuilding world,

Starting point is 00:38:43 but I was using it my little old ladies who had fractures, right? Because you could finally get them to actually heal a fracture because they would build their bone density up. They'd get some muscle mass on them. So, you know, so I used, you know, nandrolone in my little old ladies. And if you look back at the literature, that's where Nandrolone actually got its medical start was in helping with, in osteoporosis, heal osteoporosis, or MK 677, the same thing. I used it a lot in my little old people who I couldn't get enough food into them. I couldn't get muscle mass in them.

Starting point is 00:39:14 You know, I could use MK. I could get them to start eating more when they were trying to heal and recover, right? Yeah, because it increases your appetite so much. And so you have these people who are trying to recover from surgery, you know, and they're 75 years old and they, you know, and they're trying to recover from an injury. Like they fell and they have a little vertebral fracture, and they're not eating protein.

Starting point is 00:39:32 And so, you know, you can use things like M. M.K or Nandrolone, and you could actually get them to heal. So that's where I started sort of dabbling in this as kind of in that, you know, bridging that world. And then started expanding it more into the performance world, right? So, you know, I, I opened my longevity clinic about 18, 19 years ago now, but I actually did both my orthopedic by day and my longevity clinic by night. And then only really five years ago did I kind of bring them together because my orthopedic clinic was just silly to try and teach people anything in 15 minutes. So, you know, left and just now every all my orthopedic people see me here. But the key is that these, they started in this realm of

Starting point is 00:40:12 we could use them for healing. Well, now we realize we could use them a whole lot more in performance. And the bro science people do that way before, you know, but it took in the medical world moving from this, okay, how can these actually be utilized in a true healing capacity? And now we can push them into that performance side a little bit more. So I started using peptides and learning more about peptides about probably seven years ago and mostly from Bill Seeds because he's really, I think, one of the biggest experts in them. And then, you know, and then why did everybody start getting into it? Because, you know, as, as, and this, you know, we'll give the pro science credit on this one much more than the doctors because that's who started expanding them, you know, word of mouth, right? wow, I, you know, I, I, you know, tore my tendon and I was better in three months as opposed to, you know, a year later, right? You started seeing them in the athletes coming out. They're all banned by WADA, unfortunately, but, you know, but you started seeing them, you know, come out in these realms too, but used to be, you know, even before peptides got so famous, the pro athletes were using them a lot. You know, so, so I think that that's what expanded its, its realm. And now it's only, you know, really been. You know, you know,

Starting point is 00:41:24 I'm on faculty. I teach peptides to doctors, and, you know, I would still say, not very many doctors know much about peptides. But hopefully, I don't know. I mean, I would like to say the same thing happened with hormones, right? That now everybody should be using hormones, but they're not. Is everybody ever going to use peptides? No. But hopefully that, so I think, you know, you and I've watched the growth, just like we've seen, you know, the growth in hormones and and anabolics and sarums and things like that. We've watched that growth a little bit. You get to see it from the more practical aspect.

Starting point is 00:41:58 I think in the medical world, it's still not very, none of it's very well accepted, right? Yeah. Unfortunately. Well, and it's twofold, right? Because there's good and bad in both. So like for where I'm getting it from,

Starting point is 00:42:11 the good is, well, I guess this is good and bad. There's so much trial and error done. Now, there's a lot of mistakes. and mistakes being made along the road. Yeah.

Starting point is 00:42:20 Yeah. But it's, and I hate to say, I don't want to sound like negative about this. It's helped me learn information wise, but it's, I've seen people hurt themselves, which I don't, I hate seeing. But it's helped me to educate others. Don't do this. You know, like don't, don't use it this way. I mean, that's, you're right. But how, you know, there is that little piece.

Starting point is 00:42:40 I mean, that is unfortunately the fact that there are people who are willing to experiment a little bit. You know, that's, that's throughout time how we've learned something. And it's like, oh, look, there's this a really cool berry. And somebody started thinking, oh, this would work medicinally. And it did in a high, in a low dose, right? And then somebody ate too much of it and died. Right. Don't do that, right?

Starting point is 00:42:57 Unfortunately, there is a little bit of a learning curve to that, right? Unless you have the ability to test everything on animals first. I mean, the good thing about peptides is most of them have had a lot of good animal testing behind it already, right? We know in general these are very safe. In fact, much safer than hormones. Oh, yeah. It's very hard to hurt yourself with a peptide. it is much easier to hurt yourself with a hormone than a peptide.

Starting point is 00:43:21 Things like BPC or thymus and alpha-1, or, you know, you could massively dose them. You could bathe yourself in them and nothing bad would happen. And we know that from a lot of animal studies. You know, and then now we've done it with patients, right? We've used it in patients and we've tried it and we see the outcomes. But, you know, kudos to the people who, you know, in our world have had the guts to try things. And we've had the opportunity to learn from them, right? I mean, even ourselves, right?

Starting point is 00:43:48 I'm sure you've done things. We're like, well, that was a bad idea. Oh, shit. You know, but you're like, oh, I'll try this new supplement and, you know, maybe I'll try it at, you know, a little higher dose because it wasn't working well. And then else something horrible happens. Oh, no. I'm like, okay, well, I won't do that again.

Starting point is 00:44:05 So, you know, I think we're always going to learn somewhat by trial of error, my N of one experiments. The key is trying to put these N of one experiments together. I'm involved with this big group of doctors. ourselves, the longevity docs, and it's kind of from across the world. But we have this, you know, just WhatsApp chat line. And we just throw stuff into it. And you start, you know, as data starts accumulating, you could start putting together, you know, sort of a clinical trial. Yeah.

Starting point is 00:44:32 Despite the fact that it's not an expensive, pharmaceutically run clinical trial, when enough people start utilizing something in a similar fashion, we can put together these trials. And all it takes is a bunch of us kind of putting our information together. Yeah. And of one trials have a lot of use, right? Oh, you know. What a dream to be a part of something like that. Oh, man.

Starting point is 00:44:52 I would, because, you know, for me, it's like, for me to have this conversation with you right now is, would have seemed like a year ago in impossibility where I'm handcuffed to like, oh, this is underground. Oh, I got to talk to so and so. Yeah. That's interesting, right? Yeah. Yeah. For every one guy that's kind of more like me, there's 50 that are just like have this. mentality where there's nothing more important than today. We don't think long term. More is always

Starting point is 00:45:20 better. Like all of this shit I've been fighting for so long, like literally fighting for so long. And I, before I go forward, I will, I want to, I just want to thank you for something that you did for me that you don't know you did for me, which is several things. But when I started like when we were talking there and I sat and listened to some of the things you said and then I, and talking more alternative medicines, deeper thoughts and realizing there are people like you out there. It made me realize that I, and when I got COVID, I had the time to sit and think and read. Because I thought that was like, you, you know, I bitched you right away. You know, I'm sick.

Starting point is 00:45:59 I don't feel good. It gave me the opportunity to realize what I have been doing all this time was the term biohacking. And I had the opportunity to end to start conversing with people. and now I found what I was supposed to be doing. And I kind of talked to you about this. And now I've been doing the same thing for 12, 13, 14 years, and I'll never regret it because it gave me a start. But meeting you, it showed me like,

Starting point is 00:46:26 okay, now you're ready to move the direction you were supposed to go. There's people out there. It's not this underground society or whatever anymore, you know. And so for me, I couldn't be more appreciative because I feel like I've been grouped with something. that I'm internally not, you know? And it opened doors for me. And so that's, I'm just throwing this. I love that deal, because you know, you are right, I guess, that we couldn't have had this conversation a while ago. We couldn't have talked about, you know, wow, Nandrolone can actually

Starting point is 00:46:57 be used in medicine and, you know, because it was, you know, 200 grand. So you're right. We've made advances, right? Yes. And, you know, one of our passions at Boto Longivity Institute is because it's brilliant people like you who are passionate and knowledgeable from life experience, right? right, which goes a long way. See these doctors who went to medical school and they learned this sort of set protocols of things. And one of the things we realize is it's very hard to unteach these set protocols. Yeah. One of the reasons I left my orthopedic practice was because literally one day one of my partners came out to me and I, you know, I started this practice.

Starting point is 00:47:32 I'd been in practice for 30 years and, you know, and when I practice was going, you know, we don't really want, and they knew I'd start doing peptides and things in the practice. We don't really want you doing this stuff here anymore. We don't really do medicine here. We do orthopedics. And I'm experiencing, I have a very good friend who's a cardiologist, and he's in a cardiology practice, but he's doing, you know, what we would do with cardiology, right? He's not going to be putting everybody on statins and PCSKs. And recently his group came to him and said, you know what, we don't really like you

Starting point is 00:47:58 using hormones and peptides on the patients. We just want you use statins and, you know. And so he's probably going to move over and join us because, you know, so what we've realized it's very, very hard to take traditional medicine and turn them into educating people in this stuff, right? So we're going to have to rely on an army of passionate, smart people like you to educate other people who become smart, passionate people and educate other people, right? Because I don't think, as much as I would love to say, medicine's going to change, I just don't think it's going to. It's tough because of the money and the trickle-down effect. Right.

Starting point is 00:48:38 It's like a hierarchy of order. There's something else, right? There's something else that's controlling it, right? And you get down to the doctors and they say, well, if you write too much of this or don't write enough of this, we're just going to fucking drop you from the insurance altogether. And doctors can't lose network like that. It'll just direct their practices. So, you know, and it's just this like you get stuck with, okay, for example, I come from bodybuilding forums and things like that. how I got started. And the whole ideal there is, oh, doctors don't know shit. And that's what

Starting point is 00:49:15 gets passed around. And that's what it's thought in that whole community. And I fell into that for years, once again, until I met somebody like you and realized, no, no, no, no, no. Doctors are not full of shit. They know way more than we do. You just have to find the right one. Right. And so now knowing that that's there, that's like I said, that gave me an escapeability. like, okay, I don't belong here. Yes. And these are the people I need to be. I bridge the two, right?

Starting point is 00:49:44 Yes. Yeah. That's so good and it's so cool. And that's how we're going to change the paradigm. Yes. Right. It's people like you coming in doing this and your listeners going, you know, wow, okay, I can't actually change this.

Starting point is 00:49:58 I can't actually do something. I can take control of my health. I don't have to rely on a doctor to do it. I can order my own labs. If I learned how to read those labs, you know, don't abandon your doctors all together. I don't want you guys to, you know, die because of a horrible infection, but, but you've got to know the questions to ask. You've got to find the right physicians to work when you have to, you know, that's where people like you can be huge advisors to people, right?

Starting point is 00:50:17 You know, if you don't know it all, you know, that's one of things, you know, Dylan and I talked about is we, you know, we can educate people and then they can, they can act as advisors to other people, right? Yes. It's so important to have that to. Yeah. It's huge. Listen, I, even when I told you my liver numbers were up, they weren't just kind of up. I went in there in my my fucking AST or ALT. I can't remember which one was almost 300. And he's like, wow. They were like really high. Wow. Well, it's it's elevated a little bit. And I got in the car and I called my wife and I said, can you fucking believe this? It's kind of elevated. I said elevated. It's like 75 to 100's elevated. So, you know, and I was blasted in niacin and red yeast rice because I panicked with the heart stuff.

Starting point is 00:51:03 So I was laughing for the liver toxicity, right? Well, yeah. You know, I got my LP little A down in the 150s, 170s, but at what cost? So I had scale back, scale back, right? Okay. So I want to talk to you about, you know how important this one was to me, was the GLP's. Now, you are extremely well versed on this. There is a ton of bad everything.

Starting point is 00:51:27 Fuck, where do I start? Right. tell me some of the biggest misconceptions on them first. And then can you just give a brief synopsis of what they actually do and why they're beneficial? So, JLPO and Agnes, which you guys know, like the Ozempik's and Lagovis and Mangaro's, you know, those include semaglutai, which is the first generation. It's like Ozempic, and then Monjaro is the second generation to your Zepotide. And the J.P.1 agonist basically glukon-like peptide receptor agonist sit on a glukon-like peptide receptor.

Starting point is 00:51:57 and they have all sorts of benefits. One is controlling blood glucose, right? Which is where they first got their start was in treating diabetes very effectively. Now, what they found out is, wow, actually, they also worked very well for weight loss at a little bit higher dose. So that was a much bigger boon than diabetes ever would be. And they made into the weight loss world. Because once they made into the weight loss world, everybody started using them, and they

Starting point is 00:52:23 became hugely controversial. Like, number one, everybody was cheating to lose weight. and they have all these horrendous side effects, right? That's all you read about in the press. It's like now, you know, somebody has a complete gastric obstruction, and people are dying, and people are losing all their muscle mass. And I will tell you guys, I know GLP-1 very well, and that is complete and utter bullshit. So these are very, I'll tell you, we used GLP1 agonists for a long time before they ever got into the weight loss world,

Starting point is 00:52:50 not just for diabetes, but in our longevity world for all sorts of other things. because there are GLP-1 receptors on every organ in your body, including your brain, including your liver, including your kidneys, your immune cells, and your muscle. And in fact, used appropriately, when they were first designed, they were actually found to push glucose into the muscle, so help with muscle building in a diabetic population who was having trouble in muscle building.

Starting point is 00:53:14 They would actually help muscle building. So really, what happened is people started dosing these inappropriately. They started using them, you know, sort of rampantly. seen the bad consequences of doing anything that way. If I take a GOP1 agonist and I have no appetite and I stop eating, I will lose muscle, right? And these are very effective drugs that lowering your appetite. I will tell you, remarkably so. People just don't have cravings to eat.

Starting point is 00:53:39 The problem is if you don't have cravings to eat, you also stopped eating all your protein. If I stop eating my protein, I will lose muscle mass. But you can, if you can maintain somebody eating high protein while they're on the GLP1 agnus, which is something that's hard and you have to dose appropriately to do that, They will put on muscle. So as long as you get their protein intake up into the 100 gram, 120 gram, you know, or higher, depending on how big you are, range, you will put on muscle on these and you will lose fat. So the fat, the ozempic face, yeah, you get ozepic face because you lose all the fat in your face. That's a consequence of losing weight no matter how you lose weight.

Starting point is 00:54:15 But the loss of muscle should not occur. And I do not see it in my patients because I maintain that they have to stay hydrated and they have to eat protein or I will take them off the drug. So I haven't sent me their macronutrient profiles. I watch what they're eating. If they're not eating enough, I'm like, okay, we're going to have to pull back the drug because you're not eating enough. So the other thing is that if you're taking these at high doses and not eating enough fiber and things like that, then you start to get horrible constipation and people started getting

Starting point is 00:54:40 gastric obstructions. So again, not dosed appropriately, not people following appropriate diets to be on these drugs. I don't see that in my population of patients ever. You will see nausea side effects, things like that. Sometimes you have to dose them down. But the most powerful thing about these drugs is, and I take a low dose, GLP 1 every day, is their effect for other structures. Like you talked about your liver.

Starting point is 00:55:04 They are super liver protective. I had an autoimmune liver disease. Almost had to have a liver transplant about 20 years ago. It was taking an antibiotic that kicked off an autoimmune liver disease. And talk about liver functions. My one in the thousands, like 1,500. And, you know, finally got under control, but my liver has never been perfect. And so I take these because they're very liver protective.

Starting point is 00:55:26 They're in phase four trials for brain. So for dementia prevention. So they're super protective to brain, which is the main reason I take it is brain and liver because I had a mother who died of dementia. I do not want that. So I take a low dose. At a low dose, you will not lose weight. I don't need to lose weight. I have five, nine hundred three pounds.

Starting point is 00:55:41 I don't need to lose weight. But the key is I want a small dose of these as a neural protective. So they're going to get authorization probably in a year or two for dementia prevention. And then you look at immune function. The Gopin 1 agonis are tremendous for helping T cell function. So what we do a lot, almost all my patients are on GOP1 agnes as a longevity agent to protect their immune system, protect their liver. It also converts brown fat or white fat into brown fat.

Starting point is 00:56:09 So it takes metabolically inactive fat and turns into metabolically active fat. So they have so many benefits. And the press, you're reading number one, bad press cells. So, of course, you're going to pick up a magazine that says, Osepic killing people, right? And not, you know, OZepic's the best wonder drug. So, and because these are all over the place, you can buy them from any source online now

Starting point is 00:56:31 and use them however you want and not know. If I don't, they make you not want to drink, too. So you basically, you've got to drink water, you've got to eat protein, you'll do fine on these drugs. But they should be done with somebody who knows what they're doing and under guidance or learn more about them. But I think these are marked incredible drugs.

Starting point is 00:56:48 You know, if you look at the difference, so there's some of glutide, then tears up tide, and now red of true tide, which is going to be even the best of the bunch with lower side effect profile and more benefits. They all are good. They just are a little bit better each generation. So, guys, please, please stop listening to the press on this. These are such valuable drugs. And they also have some really interesting benefits for helping change behaviors. So very interestingly, yeah. So you can use them an addiction.

Starting point is 00:57:17 So people who have alcohol or drug addictions, they will actually change the desire to drink or take your drugs. But you can also use them for positive behavior reinforcements. So it was a great study done if you put somebody on GLP1 agnes and had them exercise continuously, they will more likely adopt that into their lifestyle than if they were not on the GLP1 agnus. So they seem, because of their brain effect, they actually help bring something neural pathways that form to help us reinforce both good or unreinforced bad behaviors. So these are really full drugs. And I think maybe one of the most advantageous longevity drugs is coming to existence in our past 10 years, honestly.

Starting point is 00:57:55 So for somebody that wanted the benefits like with the liver and, you know, preventing dementia issues and things like that, which one do you recommend and what kind of dose are you? So I usually end up semi-glutide just because it's less expensive and it works, right? But if people can't tolerate semi-glutide for some reason or they can afford to your appetite, then I'll go to the same-glutide. then I'll go to that. But I do some of glutide just because it's cheaper. And it's effective. The GOP1 egg is in another itself without anything else are effective. So usually I'll use GLP1.

Starting point is 00:58:25 And you microdose it. So instead of doing a bigger dose once a week, you do a small dose. And we're talking about a weight loss dose, for instance, a semi-glutide is going to be somewhere around 5 milligrams a week. So 2.5 milligrams twice a week or 5 milligrams once a week. So we'll use like maybe 0.5 milligrams twice a week or three times a week. So you're never getting into the weight loss range of the drug, but you gain the benefit. And smaller people, you can even use a smaller.

Starting point is 00:58:51 You might even use 0.25 milligrams three times a week. So you can dose these like a three time a week as I think ideal when you're doing them on a preventative basis. I get injection fatigue. So I usually do twice a week at like a point five milligram twice a week dosing for its protected benefits on myself. Okay. Selfishly, I was curious about that for myself. Yeah. I mean, I will tell you, you just from your longevity,

Starting point is 00:59:13 bend and your biohacker bend, these are really good drugs for a whole lot of reasons. But the cognitive is really important. None of us want to lose brain function. And that's why I wanted to bring this up because I'm versed on them, but not anywhere near like I am other peptides at all. Yeah. I guess for multiple reasons, but one is because most of the people that I coach and deal with or not really looking for some of that.

Starting point is 00:59:39 Now that I know the other benefits of that, too, it's, that's significant, especially when It comes to the liver, you know. Right, the liver protective benefits. Yeah. There's a lot of bodybuilders, especially using oral, you know, toxic steroids, especially. Right, you need to do some liver protection. Yeah. And he's actually very, very useful for liver protection.

Starting point is 00:59:56 Excellent. That's awesome. Are there any other benefits there that people aren't aware of that you can think of that are important to disclose? I mean, I think there's really not one. If you look at, I have a great little picture. I saw all my patients that, you know, basically shows, you know, and there's kind of, you name an organ system, these are going to be beneficial for.

Starting point is 01:00:15 They're muscles, there's immune, it's kidney, it's liver, its brain, you know, so there's not much left here. But, interestingly, there's two studies that have come out in the past two years that show musculoskeletal. So actually, in an orthopedic realm, that they are preventative against osteoarthritis as well. So they appear to slow progression or even halt progression of degenerative joint disease. And that's because when you look at these diseases, these are immune-mediated diseases. and I can modify them by modifying the immune system.

Starting point is 01:00:45 So I think that's a benefit that we're just learning about and kind of just exploring. But probably that group of patients who have, you know, multi-joint osteoarthriase, who have had, you know, a knee replaced and hip replaced. Those are other people who should be thinking about being on these drugs, too. So do you think that the returitide will be the best and most popular? Because I know. Yeah. Yeah.

Starting point is 01:01:08 Yeah. I do. you know, but it may be cost prohibitive to be doing. I mean, the good thing is on these smaller doses, it ends up being less expensive, right? Because, you know, you're not doing it with the massive therapeutic doses for weight loss. You can do a small dose. It's less expensive. But, you know, the question will be, will the bank for the buck be enough to say it's more beneficial?

Starting point is 01:01:32 I don't know that yet. And they are significantly more costly. Some of glutitis has come down to a much more reasonable price than the others yet. Like functionality wise or benefit wise, is there a significant difference between these three? Or is it just price? What's the main difference? So the main difference is a semi-glutite is just a g-l-p1 agonist. And then Red Shetor, they added a G-I-P, insulin peptide.

Starting point is 01:01:56 So basically, a G-L-P, a G-I-P. And Red Shutide actually works on three different receptors. So basically each one. And, you know, one of my friends always describes this is like, you know, they're all going to get you to the same place, but one might be like driving your Honda, the other like driving your, you know, your Ferrari, right? Right, right, right. It's probably going to get you to the same place.

Starting point is 01:02:18 It's going to be maybe a little bit better, maybe more well tolerated at, with the more expensive was. I don't know at this point, I think, especially for weight loss, Reda True Tide will far out surpass the others. Because when you get to these higher doses of these drugs, the side effect profile, like the nausea is hard to. deal with for some people. And so I think that that's the key is that you definitely decrease the side effect profile as you get to the more expensive drugs that added the GLP1 GIPs. That that side

Starting point is 01:02:52 effect profile goes down. But at the smaller doses, the side effect are pretty low anyway, right? And I don't know if the true benefits to other organs, besides weight loss, are going to be that far surpassed that it's going to be worth the money or not. Okay. I don't know if we have the answer to that yet. Because I'm thinking in my head, I'm like, because I'm going 100 miles an hour here and I'm like, what would be similar to compare it to? And I'm thinking, Viagra Sealis Levitra, right? How they went, like, boom, boom, boom. And what's the ultimate? Well, there's some differences there, but you got a little better, a little better, a little better, right? Over time. Right. Right. And these definitely got, from the weight loss perspective, bar none. Okay. The third generation of Red Tried is going to be

Starting point is 01:03:32 by far the best for weight loss with, it's going to be more powerful and it's going to have less side But I think if you're using it for its other benefits, I'm not sure it's going to have as much. It's not going to be that's such a difference. I'm going to, I, when I get home from this weekend, I have to, I'm going to start just for the benefits that you, I certainly don't need the weight loss benefits. Yeah, exactly. Yeah, you don't need to lose weight. And see to be careful.

Starting point is 01:03:57 But for you, like just a low, like a 0.5 milligram twice a week kind of dosing for you, just for liver protection, for brain protection. Really big. And immune stuff. I see definite improvement in T lymphocyte function on people on these drugs. That's what I want is the liver and the immunity. That's why, yes. I know that you don't have much time left.

Starting point is 01:04:17 If I can grab one more question from you that I'm interested in. For you, and I'm sure it's changed over the years, what do you find, and amongst people like yourself, like other doctors that are utilizing peptides, what is the most commonly used like one or prescribed one? or is it just a wide variety of ones that people kind of get put on? I think by far the most commonly used peptide is BPC. I think everybody knows about it, right? It can be used for so many things from gut. I mean, orally, it's incredible for gut protection.

Starting point is 01:04:54 If you take BPC, like if you're taking an anti-inflammatory drug and you take BPC along with the anti-inflammatory, you completely reduce the damage to the gut that occurs with the anti-inflammatory drugs. It completely prevents that. So, you know, you can use it orally very nicely for gut protection or for healing ulcers for people who have a lot of GI distress stuff. And you can use it for all its musculoskeletal benefits. And it has great glucose control benefits and it has great immune benefits. It's really one of those peptides that, you know, honestly, it's, and we know it's safety profile.

Starting point is 01:05:29 You could take a bottle of it and be fine. So, you know, and I use it both orally. Orally, you can buy it as a supplement now. So, orally, you know, you can simply you don't even need a prescription for you can buy a supplement. It still is injectable. We have to buy it. We have to use it from a compounding pharmacy.

Starting point is 01:05:43 But, you know, I do think the injectable works better when we're talking about human skeletal injuries. But for people who just want something, getting it over the counter is great. And then I think, you know, if I look at, you know, the thymic peptide, Simicin Alpha 1, Thimicin Beta 4, happens alpha-1 is a tremendous peptide for immune system health. I used it a lot during our COVID world type time, you know, ongoing. But just to protect, protect the immune system and to help, I think it's one of those peptides

Starting point is 01:06:12 that your immune system is going to start declining as you age. You want to keep maintaining that because that's a big link to longevity. And so I think the thymocin alpha-1 should be utilized by most people. Thymosin beta-4 also has huge benefits in terms of healing and recovery. Yeah. And then your growth hormones are cretogics, like the CJC, Ipermerellin, Tessmerlin, Ipenerone. Secretropin, Ceremon,

Starting point is 01:06:35 those are all, you know, probably the, kind of the next in line. But what I do with my patients is I have this kind of protocol, longevity protocol that I cycle the peptides through. I work on the mitochondria, I work on the immune system,

Starting point is 01:06:48 I work on the musculoskeletal system, we sort of cycle that through. And that, that to me is, you know, I always go by the theory, replace what you lose. You're losing,

Starting point is 01:06:56 just like you're losing hormones, you're losing these peptides. A lot of these peptides are naturally made by the body. Yeah. HK copper, PC, thymic peptides, those are all naturally made by the body. They decline as we age. Let's give them back, right?

Starting point is 01:07:08 And I would encourage people to keep watching for new ones to come out because they constantly do. Yeah, we're constantly. Yeah. And we're always looking for new stuff too. I mean, that's kind of fun thing about this field. Yeah. Because if you keep an eye on it, right?

Starting point is 01:07:20 It's so changing so rapidly and, you know. It's almost kind of difficult to keep up. It is really hard to keep up, right? Yeah. I'm reading literally people always ask, how do you keep up? I go, I read two hours of night. I just, you know, I, you know, Google, caller sends me alerts for everything I'm interested in and I'm reading papers every night.

Starting point is 01:07:36 And it's even hard to interpret research, right? It's like because so much research is warped to somebody trying to have a secondary gain. Yeah. So you have to even figure out what the right research to look at is. You know, so it's a hard field to keep up on. It's hard field to know where to get your information from, you know. I know. I was going to tell you, I actually use the BPC TB 500 gel like the, I like it.

Starting point is 01:07:59 I really like it. Topical, really. Yes. And I found that pretty useful. just for like injuries? Yes, I have, especially, like I'm dealing with some elbow shit here and some shoulder stuff and it does help a lot. I'm a big MK2866 guy for faster healing, but you can't keep taking that.

Starting point is 01:08:15 So I like the BPCTB. Yeah. Yeah. So yeah, definitely. So that, and I agree that's, so I'm, I talk to research site owners and every one of them, their top seller now. It used to always be GW 501516 and RAD 140. Now it's everybody says the same.

Starting point is 01:08:32 same as BPC 157. Yeah. Every site. So I still like Carterine a bit too. Well, yeah, yeah, shit. My own personal thing. That goes without saying, you know the cardio I do. It's right in my wheelhouse.

Starting point is 01:08:47 Exactly. I hate cardio, so it makes me actually okay with it. I know that you've been so, so. It's just nice that you gave me all this time. You've been very generous with it. and I appreciate it. I appreciate you, I really appreciate you doing what you're doing.

Starting point is 01:09:05 Thank you. It might be on so we can spread this world. I'm so anxious for us to work together more. Oh, yeah. This is like, I hope just the tip of the iceberg because I absolutely love you. I can't stress it enough.

Starting point is 01:09:17 And you're such a breath of fresh air. I've told my wife about you so much. She's probably sick of hearing about it. So I, and I want to tell people real quick about your human optimization academy because I just signed up for it the other day. And as soon as I get home from my event this weekend, I'm going to dig in on there.

Starting point is 01:09:36 If you want to just tell everybody about it real quick, because I think it's really, really valuable. What Dylan and I were talking about is how do you educate yourself? And we realize that that's hard because it's hard to figure out where to get that education. How do I learn how to look at my lab? So we actually put together a course. So if you go to BLI, what stands for BOLR longevity Institute, BLI.com, that takes you to our human optimization academy.

Starting point is 01:09:58 You can also go to forget that. Just go to border longevity. But BLIDOT Academy. Human Optimization Academy has all these courses you can do. How do you read a CBC, a CMP, your hormones? How do you look at a lipid panel? What lipids do you need to know about, right? So it teaches you

Starting point is 01:10:12 all that. And we have ongoing Q&A sessions that are really fun. We just did one a couple days ago, and those are incredible. There's a lot of doctors in there, too. So you're, you know, kind of progressive doctors and health advocates, and everybody asks very interesting questions.

Starting point is 01:10:27 So if you guys sign up there it's a good place to start and get some basic learning. So you can then just, okay, I'm just going to order these labs and I'll look at them myself. And then if I need help, I can reach out and I can find, you know, doctors. And then you can find us at bolder longevity.com. And, you know, we're certainly happy to help you go through labs and things like that as well. But please, please, please start educating yourself, start, you know, start learning this and and then educate your friends because then we'll start spreading health medicine and not disease medicine,

Starting point is 01:10:59 which is the only thing is really ultimately going to change how long we live, hopefully. Yes. And make sure to follow Dr. Eurs, Instagram, because she puts up things that are really valuable. I've learned, shit,

Starting point is 01:11:12 I learned something about menopause on there that was valuable to me. Just like these posts that come up, when they do come up, they're extremely valuable. I try to share them when they come up. If you follow me, too, but follow her on there.

Starting point is 01:11:24 And at Dr. Yorth. Yes. Yes. And I'll link everything in the description. So once again, thank you so much for your time. It was so valuable to me and so many other people. So I really appreciate it.

Starting point is 01:11:36 Thanks, Dylan. Thank you. All right, everybody. Stay tuned for plenty more to come. Dylan Jemeli and Dr. Earth, signing off.

The Dylan Gemelli Podcast - Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, ...

There aren't comments yet for this episode. Click on any sentence in the transcript to leave a comment.