The Joe Rogan Experience - #2338 - Beth Shapiro

Episode Date: June 17, 2025

Beth Shapiro, Ph.D., is an evolutionary molecular biologist and Chief Science Officer at Colossal Biosciences. She’s also the author of “Life as We Made It: How 50,000 Years of Human Innovation Refined―and Redefined―Nature.”https://www.hachettebookgroup.com/titles/beth-shapiro/life-as-we-made-it/9781541644151https://colossal.com/team/beth-shapiro-ph-d/ This episode is brought to you by WHOOP. Unlock Yourself 50% off your first box at https://www.thefarmersdog.com/rogan! Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Hello. It's very great to see you again. I am pleased to be here. It's been really interesting getting to talk to you and communicating with you and all the stuff that you guys have done that colossal has been insane. So why don't you just tell everybody what your background is and what you do. I'm a scientist. I work in a crazy field called ancient DNA, sometimes called paleogenomics. It means we go out into the world, we dig shit up and we extract DNA from it. And what

is fantastic about that is it's being a modern day explorer. I get to go somewhere, I get to find out something new that completely rewrites what we thought we knew, and it's brilliant. And I get to fight with people a lot. And because I love to fight, I recently quit my academic job and moved to become the chief science officer at Colossal, the company that has just made those dire wolves. Why do you like to fight with people? Oh, I don't really like to fight with people. I just felt like it was the right thing to say at this minute. I end up fighting with people? Oh, I don't really like to fight with people. I just felt like it was the right thing to say at this minute. I end up fighting with people, though, not because I want to,

but because I feel like I have to defend what I think is the way that we should be doing science. Well, it's certainly a controversial subject, and you guys are certainly groundbreakers. So whenever there's a controversial subject and people are groundbreakers, you're without doubt going to get a lot of pushback. And a lot of people that just want attention, a lot of people that are angry that you're

getting attention, there's a lot of stuff going on. Yeah, there's a big, I think in academia in particular, there's this big scarcity mindset. And this leads people to be kind of negative about everything. That's going to be too hard. If I say that that's good be too hard. If I say that that's good, then that means that the thing that I want to do probably isn't gonna get that money. Or if you get attention, that means I can't get attention. And it leads to this negativity that I think stifles innovation.

There's a lot of gatekeeping too. You know, we talked about that recently. There's a lot of people that want to be the only people that are allowed to either discuss or work on things. Yeah. I've spent my whole life working on this, therefore I am the only expert. And if anybody says something that disagrees with what I believe to be true, they're just wrong. I'm not even going to think about it. They're just wrong. It's unfortunate, but fortunately we live in a very unique time where you can do podcasts and podcasts get extraordinary amounts of attention.

And so I think that's also one of the reasons why people push back so much as well, is because they don't like that. They don't like that there's this unique distribution network. Yeah, there are going to be people, there are going to be colleagues of mine that are angry with me that I have come here to talk to you. And that is part of the problem. Yeah. It just seems kind of silly.

But the subject, without all that stuff, the subject is absolutely fascinating. So how did you get started in this? What did you initially want to do when you first started your career? I actually started in broadcast journalism. Really? I was started in broadcast journalism. Really? I was in high school. I was convinced that I wanted to work in broadcast journalism.

I got a job working at the local TV station. I grew up in Rome, Georgia, northwest corner of Georgia. And I got a job at the TV station where I was first operating the camera and helping people write copy. And then I got to be on air. I auditioned for a spot in the morning where I would do local cut-ins on headline news in the like 24 and 54 after the hour.

But I had to wake up really early in the morning and go to work, I was in high school, go to work, write the script, go on TV, learn to read the teleprompter. It was pretty fun and eventually got, and I was convinced that this is what I wanted to do with my career. I went to the University of Georgia.

They have a fantastic broadcast journalism school. I started off as the news director at one of the local radio stations. And this job, let's just say, wasn't particularly compatible with being a freshman in college. There were mornings when I was locked out of the bathroom, but I had only been asleep for one and a half hours after being out for too late at night doing things that I shouldn't have been doing because I was underaged, right? And had to go to work to write the news and then be on this broadcast radio station. It was terrible.

Anyway, how did I move from there to science? I took this amazing class. It's similar to a class that I ended up teaching at UC Santa Cruz recently where it was a field geology and archaeology program. And we started off on the East Coast. We learned about rocks and how to identify minerals. And then we drove across the country and slept outside in national parks and learned about the history of North America, the geological

history, the human history, everything while being there in person, drove up the West Coast, drove back around the country. It was nine weeks. And I thought to myself while I was there, this is the story that I want to tell. I want to show how people have changed this landscape over and over and over again, and about the opportunities that we have to be able to become more creative controllers of this landscape. So I thought, I'll get a degree in science because I know how to do broadcast journalism, you know, the ignorance of somebody who thinks they're an expert in something. I know how to do that, so I'll just do this other thing.

And that's the history of it. I just kind of got sucked into being the scientist. I've written a couple of popular books, which is still me trying to reach back out. I want to be a communicator, but I also want to be a scientist because it's so much fun. So you just followed your fascination, which is the best advice anyone could ever get. Yeah. How did I pick a field working in ancient DNA? This is something I had no idea about. I ended up not getting the scholarship that I wanted to get and not getting into the university that I wanted to get into, but wandering around the halls of the university that I did get

into. And I met this guy called Alan Cooper, who was one of the few people in the world at the time, this was the late 1990s, who'd set up the special kind of lab that you need to be able to extract DNA from bones. So this DNA is in terrible condition, so we have to have a purpose-built clean room to make sure that we don't spit in something or drop an eyelash in something, because then your DNA, which is in great condition, will be the thing that we amplify. So we had one of these labs, and I thought, well, that's kind of cool, because I was

interested in geology, I was interested in human history. Maybe I can use this as a way of telling stories that haven't been told before or rewriting the stories that we keep telling. This was a time where we were learning a lot about human history and human ancestry and there was a lot more to be learned. And so I thought this would be cool, but I wasn't sure. And Alan said, well, you know, it'd be cool. This would be fun. Plus if you join my lab, you can go to Siberia. And I was in, I was like, yeah, sure Plus, if you join my lab, you can go to Siberia. And I was in. I was like, yeah, sure.

That's the deal for me. I'll go to Siberia. Whoa. So you got sent to Siberia? That's usually what they do to you in the Soviet Union when you're bad. Yeah. Well, I mean, I have had several not amazing experiences

in Siberia, but overall, it's been fun. I've been a couple of times Yeah, what time of year did you go summer? Oh, yeah So the first time I went it was for a meeting and I spent some time in Moscow First as a guest of one of my Russian collaborators And then we went out to this meeting in Yakutsk and we got a on a boat What I learned about Siberia is that everything goes wrong There's no bit of infrastructure that functions the way it's supposed to function and I learned about Siberia is that everything goes wrong. There's no bit

of infrastructure that functions the way it's supposed to function. And I learned that initially. We ended up on this boat that was two hours late. It was warm and hot. And there are so many mosquitoes. I was going to ask you about that. I've heard the mosquitoes are insane. So crazy. Like one of the times I was out in Timor, the North Central Timor Peninsula, and we had brought with us this weird tent that we'd set up so that we could go inside and take the masks, take the masks off of our face,

because you always have to wear a hood, otherwise you'll be breathing mosquitoes. And we were going outside and playing this game where we would just clap our hands in front of our face and then count how many you killed. And one time I killed something like 35 mosquitoes in one clap, and it's just awful. It's miserable. how many you killed. And one time I killed something like 35 mosquitoes in one clap. And it's just awful.

It's miserable. So they're trying to sting you through your clothes. They're just, they're big too, right? Well, it depends the time of year. And early in the season, they're really big and you can catch them fast. And then they get different species come out that are smaller and smaller.

And toward the end of the season, they're really tiny. Once I was up in the North of Alaska on the Ickpickpuck River, we were floating down the river looking for mammoth bones and tusks and things like that. And it had been windy for the first few days so it was fine. And I was, this was my first time out in the field actually. It was a northern Alaska and I was like, these mosquitoes, people keep telling me there's mosquitoes, they're full of shit, there's no mosquitoes out here. Right? The wind is blowing then the wind dies down and then it's like, oh, fuck.

This is awful. There was a moose that was ahead of us for a while, and this poor animal, we were following the river, and he would, every few steps, he would just totally submerge his body in this frozen water and then come back up. The mosquitoes are just, yeah, something else. I've only been to Anchorage.

Well, I've been to a couple pots of Alaska, I was in Anchorage and when I was there it was the summertime we were salmon fishing my friend Ari and I and we got bug repellent because we heard you got to spray mosquito spray. We stepped out of the car the moment we opened up the car door there was a cloud of mosquitoes we're shrieking like little girls. We're like, ah! Like what the hell? I'd never experienced anything like it in my life.

Like where'd they come from? Right. You don't expect it. There was nothing there. It wasn't like we saw a cloud of mosquitoes, but we opened up. It was an impossible amount of mosquitoes that got into the car. It's terrible. In time era, I remember we would walk along the grass, this sort of tall grass with little flowers in it, exactly the kind

of place you could imagine mammoths roaming and being like the kings of the universe there. But as you were walking, you would kick up the grass and they would just emerge off of the needles of grass. It was just really awful. Well, they're so aggressive because they only have like three months to live. Yeah. And I learned actually, because I was curious about this, how do they survive if there are so few red blood, because mosquitoes mostly they take a, they only take a, it's only the females that take a blood meal and they only take a blood meal when they're making eggs or making a brew. They take it to reproduce. Otherwise they feed on nectar. So how do these,

how do so many mosquitoes survive in the Arctic if there's so few animals there? And it turns out those mosquitoes are adapted to this climate and they don't need a blood meal to reproduce, but they do better if they get one. So they're after you, but they don't need you. Whoa. It kind of makes it worse, right? Whoa. It really is fascinating how aggressive they are. Yeah. Because, you know, Texas has mosquitoes, but they can live all year round

So they kind of chill. Yeah, they're not that worried about you My boss was so funny to Alan Cooper the guy I went to work with he was all oh I'm gonna just wear this natural mosquito repellent and you don't need any of the stuff that actually has poisons in it Look at me at my natural and we're out there and the wind dries down the mosquitoes come and I'm with my DEET I'm like, you know your natural appellant he's going you did you bring the Deet yeah yeah yeah you give up on that natural stuff real quick I was watching a documentary they're using pine pitch there's a have you ever seen Werner Herzog's film happy people life in the taiga it's really good it's really

fascinating he follows these people that live on the taiga, it's really good. It's really fascinating. He follows these people that live on the Taiga River in Siberia. Cool. And it's all these subsistence people that are like fishing and trapping and they're living in these little cabins and they bring dogs with them everywhere. They travel around on snowmobiles. Really, what's amazing about it is the title is happy people. They're all happy. That's what's so weird. It's like these people have a very hard life, but yet they're always smiling and they're having a good time and, you know, living this subsistence lifestyle somehow or another is like very fulfilling at like a, I don't want to say a genetic level, but like an internal level. Like there's something about it, like this makes sense.

Whereas society, like today, I don't think it makes sense. Because I think we, you know, you're a geneticist, you understand genes. We essentially have the same genes that people have 10,000 years ago had. Very different world. Right. And we're not really designed for this world. Right. Well, you can see that in the increased rates of obesity, increased rates of diabetes, we're not. Also depression, anxiety, all that stuff. And this is what happy people is kind of all about. I mean, Werner Herzog is this, you know, he's brilliant. And so he's narrating this whole thing too. You kind of get this understanding of his appreciation for these

people that are living this very basic life, but are very happy. Yeah, it's impressive. When we were up there in time air, we'd flown for a couple days in this really awful Russian helicopter that took off the third time it tried to because, you know, infrastructure doesn't work in Siberia. It's a repeated theme from... I don't know, Siberian helicopter. It was an MI-8 and it was in a place called Khatanga, which is where we were based while we were trying to get out into.

And they kept loading all of our gear into this and it's mostly these massive gas tanks. And you load all the gear into the gas tanks and then all of the people, we had a dog Pasha who was with us who did not want to get in the helicopter. I think the dog was the smartest person in our expedition team. But they would load us up and they would try to start the helicopter and it wouldn't start and they would unload us. We would go back to the places we were staying and then they would tinker with it and fix it. Anyway, we flew out. We got in the helicopter finally. We got up into the air and then the Russian and French leaders

of our expedition team decided that they were going to celebrate finally having taken off in this helicopter by smoking, right? We're sitting on the gas tanks, right? In this helicopter that we already think. Right. Fortunately, the helicopter had some missing windows. So you know, there was, there was airflow. It's fine.

No, this was insane. This whole, this, this particular expedition was particularly insane compared to other things in it. So also in the, I'm going to get to the story and eventually, but also in part of this, we were traveling forever out into this part of the time era where they had predicted that we would be able to find mammoth bones and woolly rhino bones and all the bones of the animals were interested in us that were flying out there and we start start to land and I'm thinking, great, we're there. I get out of this crazy fire bomb in the air that I'm in. We're going to, we let no, no, we did not get off. Instead, we picked up a random family that had been out there on

their own. Parents, a child. Yeah, it was two parents and a child. And they had backpack with their gear and a massive cooler. Right, that's what they had. No words, they're French, they speak French to the team that's there. People are having a conversation in Russian and then we take off again. And I'm thinking... Pete Was that planned to pick these people up or were they trapped? Jess I think it was planned. Just there was a lack of communication. But whatever, the helicopter took off twice and then it landed and everybody unloaded and we set up the tent, the camp. And we discovered over the course of the next few days, you know, we built these cool boats, the zodiacs, you can blow them up and you bring

out the outboard and you put them on the lake and we're looking around and we discovered that we had landed in a place where we were going to be for six weeks that had been glaciated during the last ice age, which meant that our chances of finding what we wanted were really small. Oh, no. I know. It was devastating. And the Russian—we had a cook with us. The Russian cooks had brought medical ethanol because it weighed less per unit of alcohol than vodka, which they would normally bring on the helicopter

So they brought medical ethanol to drink and whoa Well, you know, you can only take so much stuff with you. It weighs less than alcohol. That's a crazy decision Well, you know they decided it was safe. Anyway by three days in it's 24 hours sunlight We're at 72 degrees latitude. Did you try it? The medical ethanol? I tried the medical ethanol.

I mean, obviously. You water it down with a little bit of river water, and you have it with your freshly caught fish that you've laid. And yeah, it's great. We had fish and rice for the whole time. So you had to catch your food. We had to catch our food, yes.

Luckily, there's probably a lot of fish up there. Fish and there were some geese and some ducks that they would try to shoot while we were on our zodiacs. Normally, without telling us that they were about to shoot, it was a very logistic thing. So you just hear boom, boom. Or you'd be sitting there looking at something and suddenly the zodiac would take off because whoever was in charge had seen something he wanted to shoot at in the distance. Anyway, I don't know why I'm telling this story.

Because it's fun. It's a fun story. So we were there. We're there for, I don't know, maybe it was two or three days looking around and it was about two o'clock in the morning. We were inside this little tent that we'd built so that we could eat in it, sort of the kitchen tent where we were. And it was a big mesh tent to keep the mosquitoes out so that we

didn't have to have anything. And everybody is just staring off into the distance glumly. The medical ethanol was gone. You know, everybody was sober. We were going to be for the next five weeks, we were going to be stuck in this place where we weren't going to be able to find what we were. And then all of a sudden, these three dudes show up outside of our tent with machine guns. Right. And I'm thinking, everybody's thinking, what the fuck? Like we just flew forever in a helicopter over nothing at all. Nothing except for this French family that we picked up randomly along the way. And everybody's looking around and there's this real moment of what the hell are we going

to do? And then the guy who was the expedition leader recognizes these two dudes and there's this real moment of what the hell are we gonna do? And then the guy who was the expedition leader recognizes these two dudes and he's like raw friends oh good to see you blah blah blah and I'm thinking what's gonna happen when they realize we don't have any more vodka medical ethanol? And it turns out that they are they were members of the Dolgan community, which is an actual family of subsistence people that still live up on the time air. They heard reindeer and they had seen the helicopter and had wondered what we were up to and just set out over the landscape that they normally live on to try to find us.

Wow. Yeah, pretty cool, actually. That's cool. So did you hang out with those people? Well, we did. They were disappointed that we didn't have any alcohol, obviously. This episode is brought to you by Whoop. The all new Whoop is here, the only wearable that turns your health and fitness data into personalized guidance. Now, 7% smaller with more than 14 days of battery life. Whatever you're training for, the insights you get from Whoop will totally change the way you rest, train, and show up every day.

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It's a theme. It was Russia, so it's a fair theme. But the French couple, this is just, you're not going to believe me when I say this, right? Okay. The French couple said, I got this. And they get up and they go back to their little tent area that they'd set up in middle of nowhere, and they bring back their cooler, and they open it up, and inside is cheese. Like a massive gouda, and a massive brie. Why? I don't know. I don't know, right? But they had cheese. And so we cut the cheese and shared the cheese with our Dolgan friends and they were happy. And the next day we took them back with the zodiacs to their community. And you know what was most amazing about this experience? And everything about it was cool. We saw these people that were living

in these tiny little huts in part of the world where it goes to 40 below and it doesn't matter if it's Fahrenheit or Celsius because they cross at that level right it's 40 below and during the winter for months and dark and they're herding reindeer and they're living in these tiny little things that they cut in half during the winter so that half of it is used for heating and half of it is used for the family to live in. Everything that they own is on these things, on skids that the reindeer drag across the tundra, across the permafrost in the snow or in the summer trying to find the land for the animals to graze. And this

is how they live. And that was the only time in that experience where I could take off the headnet because the mosquitoes didn't care about me around those animals. It was really impressive. They only wanted to attack the animals? They were after the animals and they really left us alone. Probably because that's their natural source. Yeah more natural than... there's more of them there. I mean I don't know maybe they're larger but it was... They're probably accustomed to it right? Though also like for thousands of years they've probably been just feeding off of reindeer.

Yeah, I think about that, though. But I think about that poor moose from Alaska who was also clearly bothered by the mosquitoes. I imagine the reindeer were as well, but it was pretty cool. Were these people riding the reindeer? They did ride them. In fact, I got to... Wow. They put me up there and showed me how I could ride the reindeer.

Yes. Is this their place? Yes. Yeah. Wow. So I could ride the reindeer. Yes. Yeah So you were in this area? Yes. Yeah, I was there during the summer though. So it wasn't there wasn't snow on the ground It was all just a very grassy wet super wet grassy and the moisture in the ground is probably why there are So many mosquitoes it is so fascinating to me that people will live like this generation after generation after generation Yeah, and the fact that you can somehow these are one of the weird animals to me that people will live like this generation after generation after generation. And the fact that you can somehow, these are one of the weird animals, caribou are, that you can herd.

Yeah. And people ride them. And milk them? Yeah. Yeah. And then occasionally whack one. Yeah. I mean, they're great, right?

So this is, animals have always been a really great storage mechanism. That's one of the hypotheses about animal domestication. Why did this take place? If we had plants, but there are going to be years where there's plenty to eat and years where there's not enough to eat. But in those years where there's plenty, if you store some of that nutrition in animals, then in the years where there's less, you can eat those animals. So it's a very safe way of storing what you can grow. That's a fascinating way to look at storing. I just want to know how they ever figured out how to herd those reindeer.

What did you do? Who was the first person to figure out how to get them all to stay together? Right. I think that about a lot of domestic animals. I also think that about milk. Who was the first person who decided, I can have a go at that?

They're probably starving. They must have tried everything. I mean, that's how we found out what mushrooms are edible, right? Because a large percentage of them will just kill you immediately. But people are so desperate for anything. Yeah. Some of them are trying to tell you though by being like bright red or bright purple and saying, right, right, right.

But we're dumb. So we're like bright red. I'll lick that. Yeah, it might be an apple. It's confusing. Some bright red things are delicious. It's really good for you. Wow. So these people that live up there What was their history like had they been living up there their whole life those particular individuals have yeah but I think they're they have a long history that the culture has a long history there and

I mean, we're still, I think, we're still learning about how humans have dispersed around the world and how they got to be the places where they are today. But I really think it's impressive that there are people who are hanging on to that culture. Absolutely. And really able to, you know, they're trying now to relearn their native languages, because during the communist era, they were all forced to learn Russian, and speak Russian the same way as everyone else. But even up there, even up there. Wow.

And if they sent an emissary and say, guys, it's time to speak the mother tongue. Maybe they had to go to the squares like you see in Yakutsk and all these other places where they have the big squares with the speakers on the top where they would go for the daily admonishings or whatever from the Communist Party, who knows. Wow. What a weird way to live. It's so fascinating that there's pockets of these humans that live like this all over the world. Obviously, the people in the Amazon, the uncontacted tribes of the world, it's just so interesting. And we have so much to learn from them. I think any it would be I mean, obviously

that's such a cool job how getting to go and actually try to communicate with people who haven't been talking before but you kind of don't want to because you don't want to ruin that. Right. Isn't that an interesting perspective because I don't want to live like that. Like I don't want to live in the Amazon. I'm going to leaf over my private parts. But we assume they do. Even for a week. Nope. Don't want to do it. There's so many things out there that'll eat you. There's so many bugs that can kill you and snakes that can kill you. It's like, uh-uh.

I'd rather watch a video. Right. David Attenborough documentary. I don't want to go there. I have a good friend who lives there, Paul Rosalie. He goes there all the time. He's been on the podcast a few times. And he lives in the Amazon.

And his whole thing is he's there all the time. He's been on the podcast a few times and he lives in the Amazon and his whole thing is He's there protecting the rainforest and what they do is they take these people that are they're just poor people that have no options And they're loggers and so he pays them more money to protect the rainforest So they get to quit the logging job and then protect the rainforest and then through funding They they buy a parcel so land and protect and save it but he's had some gnarly encounters with uncontacted people where at one point in time they realized they were they were actually being hunted and they barely escaped with their life. Holy shit. And you start hearing weird noises in the bushes and then you realize like oh boy these are

people like we're being stalked right now. By the most sophisticated hunting animal out there. Not only that, I would imagine at the stage that these people are at, they've been living there for thousands and thousands of years, they probably have incredible perception, incredible senses. Because they have to. Right. They probably knew these people were coming a long time ago. They probably heard the boat coming down the river. They prepared.

They got ready. They know where all the paths are. They know which way the people would go. You're utterly helpless. How did he get out of this? They got out just in time. Just in time. They just escaped.

Yeah. But one of his friends, one of the people that he was working with, did not. They would have these gifts, so they would take these rafts and try to make contact with these people. They would float these rafts towards them filled with food. And they were doing this as a peace gesture. And this guy had done this several times. And then one time he didn't come back and they found him filled with arrows.

Wow. Yeah, they just killed him. They just decided you know maybe they had a bad experience with some other person from some some other Westerner and they decided you know we're done. But they're rightly terrified of humans because when these people that come in that want to extract resources, whether it's the loggers or whatever it is, if there's some minerals or anything else they find there, they just kill everybody. There's horrific human rights violations that occur there, where they just hire the worst people in the world to go in and wipe out these tribes because these tribes are resisting

them taking over this land. We have a history of this. Yeah, we do. We have a deep history which is really fascinating about the Amazon in particular because you know we've had a bunch of conversations on one of them recently with Luke Caverns where we went over the LIDAR discoveries of these sophisticated grids and all the stuff that's in the Amazon where they really thought that this was just rainforest forever and then slowly over time they realized, no, there was like a huge civilization

here of millions of people. So these people that are the uncontacted people, I mean, I wonder how many of them were like the preppers of the Amazon world from, you know, 4,000 years ago or whatever it was. It wasn't even that long ago. The Percy Fawcett, Percy Fawcett, right? That's his name? Yeah. The guy who, one of the guys who, that's, he's the main character in that book, The

Lost City of Z. He's one of the people that went there. When they, when the first settlers went there, when the first explorers went there, they talked about these incredible, like sophisticated civilizations. And then people went back 100 years and there was none of that. So they thought that they had just made it up. It turns out the first people probably gave these folks horrible diseases and it wiped out millions of people. And then the jungle just consumed whatever structures and houses and stuff that they

had and all that's left is these grids that you can see when you fly over in LiDAR. Yeah, that's so cool. You can see those when you're flying over any part of the world, really. I noticed it recently was flying over Europe and you can see the old trellises from old, you know, I don't know how old, but it's just so cool how we can see remnants of civilizations and just makes you think, what happened? Like this is some of the coolest mysteries That's what's so cool about working in ancient DNA too is we can just go to places Get DNA from stuff and learn something that we never knew before. It's fun. So you

Get interested in DNA you go to Siberia all that jazz. How do you get started working with a company like Colossal? How does that take place? All of us working in ancient DNA, we are constantly answering the same question from the media, which is when are we going to bring dinosaurs back to life? Because Jurassic Park? Yeah. Great. We're so simple.

One great movie and everybody's like, when's that going to happen? And people say, people actually say that my field was spawned by Jurassic Park. The whole idea that we could get DNA stuff, that's not true. It was actually the other way around. And Michael Crichton, when he wrote the book that became the movie, he credited a lab at Berkeley, Alan Wilson's group, the Extinct Species Study Group, which was the first group to show that you could get DNA in something after it died. That was actually from a quagga, which is a type of zebra.

They had gotten... What a cool name. Yeah, right, well, in Dutch and South Africa, they actually say the quagga. Ooh, even better. Yeah, it's better that way, but it's kind of bad for the microphone, probably. Gross. Quagga. Yeah. I think it's better that way. But yeah, it's kind of bad for the microphone probably gross

I think it's the sound they're supposed to make right? Oh, so they sound like that. I don't know who knows. Hmm anyway, they showed that you could get DNA from this skin and Everybody was like that is the coolest thing that I've heard in a long time That must mean we can bring dinosaurs back to life. And everybody started racing to get the oldest and coolest DNA. And so there were papers in the best journals of science that never published anything that's wrong ever, ever, that said, look, here's dinosaur DNA. And look, here's DNA from a myosin-aged leaf. And look, here's this. And all of it is crap. We now know. In fact, the first dinosaur DNA sequences that were published, if you took them at the time and you typed them into the internet and you compared

them to the earliest of what is today this big repository of all DNA sequences of everything that's ever been sequenced, what came back was a close match to a bird. We now know because there's more DNA sequences there that it was a chicken, an exact match to a bird. We now know, because there's more DNA sequences there, that it was a chicken, an exact match to a chicken, and some investigative work found that the excavation team had been working on those bones had fried chicken for lunch every day. So it's chicken contamination. Yeah, it's like greasy fingers on your dinosaur fossils. And look, now we have ancient DNA. That is hilarious. That's how little they knew about DNA. What year was this around? That would be the early 90s.

The early 90s. And when was DNA first discovered? The idea of DNA is much older than that. But it was really, what really helped this field along was the invention of PCR. It's an acronym for polymerase chain reaction. It's a way of- Kary Mullis. Kary Mullis, who discovered the idea of PCR while he was high on a road trip. On LSD.

Yeah. That's right. Yeah. We should all do LSD, I think, because clearly you have your best ideas when you're high. Some people have great ideas. Some people go kooky. Some people lose their marbles and never come back. Yeah, I think I probably would not have good ideas on LSD, but I'm willing to give it a

shot. I like your scientific exploration mind. A good scientist always wants to know. You never know. Maybe there's a breakthrough waiting behind that little piece of paper. Probably not, but you never know. Anyway, he discovered a way to photocopy DNA to make lots of copies of the same thing, which then made it possible to learn the sequence using the technologies of the day. And that was what made it possible really for ancient DNA to take off, was this ability to photocopy. Because when an animal dies or plant dies, the DNA in the cell starts

to get chopped up into smaller and smaller pieces by things like UV, right? We go out in the sun, we put sunscreen on, and that stops the UV from breaking our DNA. But it's not terrible to get some sunlight, as you probably just saw. There was an article out saying, hey dummies, you know, we need some sunlight in order to make vitamin D. But we have a repair mechanism so that when your DNA breaks, it doesn't stay that way. We evolved this mechanism. But once you're dead, you no longer have the energy for that to work. And so these damaged parts of DNA accumulate. And also things like bacteria and microbes get in there and chew up the

DNA to recycle the animal to the next generation or plant or whatever. And so the DNA that we get in an old thing, like a mammoth bone, is really short fragments, like maybe 30 or 40 or 50 letters of DNA long. In comparison, if I were to take a swab from my cheek and sequence that, I could get strings that are hundreds of millions of letters long. This is living DNA. So ancient DNA is in really crap condition, and it's also mixed with stuff. So if I extract DNA from a mammoth, I'll get some mammoth DNA, but I'll get a lot of those microbes

that are in there chewing up DNA. I'll probably get some of my DNA because I touched that mammoth bone. Get DNA from whoever else touched that thing. This has been a real problem in archeology because we're trying to get DNA from humans, but we are humans, and so we touch these things, and then I don't know if it's

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Tap the banner or visit this episode's page to learn more. Offer applicable for new customers only. Even just breathing on it, right? Yeah, or dropping an eyelash. In my lab at Santa Cruz and in ancient DNA labs around the world, we have these really sufficient... It's like working in a virus lab where you're scared of everything, but we turn it around. So rather than having the air being sucked in, we're kind of trying to push the air out.

We don't want any air coming in. We wear these suits where it looks like we're terrified, you know, with a face mask and hair net and we're totally covered and we bleach everything. It's not because we're afraid of those bones. We're afraid that we're going to get our DNA in that bone and then we're not going to be able to do our work. Of course. Yeah. So it took that and the ability to amplify those tiny little pieces of DNA for us to really figure out that we could get DNA out of things.

For a long time, people thought we were never going to get DNA out of Neanderthal bones because of this problem. We touch a bone, we're just going to get human DNA, and we're never going to be able to know the difference. But then with PCR, with the ability to work in these clean labs and distinguish, we eventually got whole Neanderthal genomes, which I think is probably one of the crowning achievements of my field. Ancient DNA, Svante Pabbo won the Nobel Prize a few years ago for this. What did they extract it from?

Bones, different bones. The very first Neanderthal genome sequence was actually a mixture of several bones because there wasn't very much DNA in any of them and they weren't able to pull it together. It's actually my husband who was on part of that team who put together the first Neanderthal genome sequence. Wow. Yeah, it was cool. That's really cool.

But then they, the Denisovans, the Denisova people, that was just a tiny little piece of a finger bone that they had no idea was going to belong to a totally new species of human, right? And they were able to get a really high coverage whole genome out of this tiny little finger bone that totally rewrote what we thought we knew about evolutionary history. And that's pretty recently, right? Yeah. Yeah. Within the last decade. Jamie and I, we did a podcast recently where we were talking about the big head people.

What are they called again? Juliani or something? Juliennes? I've seen this. This is really super recent. It was like December of twenty twenty four. They released this paper. Yeah.

Super cool. And it just highlights how much we don't know. Right. How every especially in paleoanthropology. And this is a field where people will take like. Yeah. Jewelry and jewelry. That's it.

This lost species of humans with an abnormally large skull which lived alongside Homo sapiens So they died off somewhere. They lived in China between 300,000 and 50,000 years ago Yeah and so if they were able to breed with humans they probably did and they probably bred with Neanderthals and they probably bred with Denisovans because you know, that's what we do. Wild stuff. Yeah. Yeah and then of course the Hobbit people, the island of Flores people. Yeah Flores. A little tiny. No one

has still been able to get DNA from those samples now but I mean someday someday it'll happen. We've tried, Sponti's team has tried, a lot of people have attempted, it's just they're too degraded. They're from a hot place. All of those things that degrade DNA, it happens faster in hot places. Right. That makes sense. Yeah.

There's probably a lot more to be discovered too. So much. I mean, they only really found it out of one location, right? Yes. Yeah. And one thing that people have tested, actually this again was work that my husband did, was whether the people who live there today, the Rompasasa people, are related to them and they're not. It seems like, because they're small as well.

And the question is, is there something weird about them? This is actually really cool. It was a really cool result. It's hard to know exactly what bits of changes in your DNA code for making you big or small. But clearly it's not just one thing because there's not just people my size and people normal size. I'm only five feet tall, right? We have a big spectrum of help.

So there's lots of different genes that are involved with this. But we kind of have an idea of where those genes are in a genome and what they might be. And with these people who are all small, the idea, the hypothesis was that there was some new thing in their DNA that led to them being small. But it wasn't. They just are at the extreme of all the things we already know. Is it just island dwarfism? It's just a small population on an island. Different alleles go to fixation. And yes,

I mean, weird things happen on islands. Elephants even. Elephants dwarf. Yeah, but dodos, dodos got bigger. And so do lizards. They dwarf or they get bigger? They get bigger, yeah, like the Komodo. Oh yeah, that's one of the scariest animals. Creepiest animal.

I'm so embarrassed to tell you how many times I've watched videos of them eating large animals whole. Like cattle? Yeah, they eat sheep and monkeys, it's horrific. Why do we watch that? I don't know. You're like, is this gonna happen? You know, you open up Instagram like, oh no, you see this pork oat and you see this slobbery lizard. And you can't help, you're like, I'm like, I'm gonna watch. They're so gross. Their mouth is filled with botulism.

Is that what kills them? The botulism? I think there's a venom as well. They think there's a lot of toxins in their mouth and I think there's also a venom. I think they used to think it was just poison, just botulism and just various bacteria, but now I believe they think it's a venom. I watched another horrible video where they would bite this buffalo. They just bite its hindquarters and then follow it while the venom is slowly taking its, running its toll through the body. And then eventually the poor buffalo gets to the point where it can't move and they start eating it alive.

I think I've seen that one. I do. I think I've seen that one. Nature is so rough. Would you go? It's so brutal. To Komodo Island, no chance. Really? No, I remember Sharon Stone's husband, I believe he was either a journalist or someone who owned a newspaper or something like that, and they went to see the Komodo dragons at the zoo. I think it was in San Francisco.

And they took their shoes off when they enter into this Komodo dragon area to like not contaminate. And apparently he had white socks on and They decided that his foot looked delicious And they bit him. Yeah. Yeah, I don't know what happened with that This was you know an ex-husband of hers back in the dis a maybe that's what she planned the X I don't think she did I think it was just one of those things with this guy just didn't know what he was getting into and I think it was just one of those things where this guy just didn't know what he was getting into and should have had white socks on or just it's just doing what a Komodo dragon

does and biting whatever it can. I wouldn't have thought white socks. Here it is. Bronstein underwent surgery to reattach several thousand severed tendons and severed tendons and to rebuild his big toe that was crushed by the dragon's jaws. Oh, it's just missing his face. Oh, oh, tendon's end. Okay.

Oh, so he was done, was able to pry open the reptile's mouth and escape through a small feeding door in the cage while the zookeeper distracted the dragon. Oh my God. Wait, he was in the feeding cage? Yeah, whoopsies. Oh, they mistook his, his white tennis shoes. That's what it was. It wasn't socks So this story is old this story is from they had him take it off It was oh they had to remove his white. Yeah. Oh, it's a shoeless foot. Oh

So they thought that his tennis shoes would look like the rats So they told him take your shoes off so they don't look like the rats instead it looks like flesh. Oh my god. This sounds like someone did a dumb thing. Absolutely. A lot of dumb things. What year is this Jamie? 2001. Yeah. Well bad decisions, bad outcomes. Yeah. No I'm not going to Komodo Island. Or in the feeding cage at a zoo. No, no, I'm not going to any of those places. No, no, no, no, no, no.

I get it. I like, I know what they are. I can watch them through the cage. I'm good. I don't need the additional thrill. Right. But there are places where there are big things like dodos that are amazing and probably not going to kill you.

Sure. There's some stuff that won't kill you, like giraffes. Giraffes. I've been told that a giraffe is the dumbest animal. Really? Yeah. I didn't know this and I wouldn't have suspected it because they're so gorgeous and you wouldn't think that something that gorgeous would be so dumb.

But I have friends who are, Matt James, who's the chief animal officer at Colossal, he's worked with at lots of different zoos throughout his career. And he's told me that there are multiple occasions where he has had to save a giraffe from accidentally killing itself because it's so dumb. Wow. Well, they're so kind that they let babies feed them. Yeah. There's nothing going on.

When my kids were little, you could go to the San Diego Zoo and you would give them lettuce and little babies are allowed to hold up, like a two-year-old can hold up their When kids were little, you could go to the San Diego Zoo and you would give them lettuce. And little babies are allowed to hold up, like a two-year-old can hold up their arm and this enormous tongue comes wrapping around that piece of lettuce and they giggle and everything. But they trust them so much that they let little kids feed them. Like they set it up so people can feed these and they seem so calm. Docile.

Yeah, like they're just happy they're not getting eaten by lions. Sounds a little dangerous to me, though. If they are genuinely stupid, will they accidentally at some point take that baby's hand? And then they have huge, strong necks. The writhers. Oh, yeah, they fight each other with their necks. This is, they're kind of smart.

Oh, really? But this is, I don't know. The ability to make inferences based on statistical information has so far been tested only on animals having large brains in relation to their body size like primates and parrots. They tested giraffes despite having a smaller relative brain size can rely on relative frequencies to predict sampling outcomes. They presented them with two transparent containers filled with different quantities of highly liked food and less preferred food.

The experimenter covertly drew one piece of food from each container and let the giraffes choose between the two options. In the first task, we varied the quantity and relative frequency of the highly liked and less preferred food pieces. In the second task, we inserted a physical barrier in both containers, so giraffes only had to take

into account the upper part of the container when predicting the outcome. In both tasks, giraffes successfully selected the container more likely to provide highly liked food, integrating physical information to correctly predict sampling information. Huh. I mean, cool. But I also trust a person who has tried to keep giraffes from killing themselves by doing dumb things to tell me that a giraffe isn't always making the best decisions.

Perhaps they're intelligent for the environment they belong in. I'm sure that's true. I mean, that's how evolution works. Yeah, but when you put them in the zoo, they're like, look, grab all our food. There's a wire I can get my neck stuck in. You know, like a kid that never leaves his parents basement and plays Call of Duty till he's 35, you know, probably doesn't have like the best social intelligence. Probably not the... that never leaves his parents basement and plays Call of Duty till he's 35, you know, probably doesn't have like the best social intelligence. Probably not the... probably gonna be pretty awkward when you get him out in the wild. Probably. Yeah. Yeah. It's probably the same thing with your house. Yeah. Did you hear that James? Talking to my 15 year old. Oh, I used to play a lot of video games. They're very

addictive. It's a real problem and they're gonna get worse. They're gonna get way better, you know. As science makes things more and more addictive, it's a real problem. And they're gonna get worse, they're gonna get way better. As science makes things more and more addictive, one of the things they're really good at, these designers. And algorithms. Oh yeah, but they're just so good at making games that are just incredibly compelling. And fun. Oh, so fun, way more fun than going outside

and getting bullied, you know? That's the problem. You could be a badass at Call of Duty. All you do is sit in there. Or War Thunder, that's the problem. And you know, you could be a badass at Call of Duty. All you do is sit in there. Or War Thunder. That's the game that my son is into. War Thunder. I don't know about that one.

What's that one? It's about like planes and things that you build and then fight. Yeah, pretty crazy stuff. Yeah. Just imagine if you could take one of those Denisovans and show them that. That is an interesting question. What would we do if we could bring a Neanderthal or a Denisovan back, de-extinct one of them? We are not doing that at Colossal. They're humans. We cannot ask them for consent to do this. We're not working on

them. You won't. China's like, tell me more. Maybe. I think it's a bad idea, but if they do, I would like to know. There's a lot of people that think bringing dire wolves back is a bad idea. Well, I mean, what did you think of the dire wolves? Well, fortunately, after the last podcast I did with Ben, I did actually get to go visit them and I was blown away. It's extraordinary. It's so wide. I mean, it's one thing to see them in photographs, but it's another thing to be close to them Where you're you're outside There's no fence between you and them and you look in their eyes and like that is a different animal

Yeah, that is a totally different. I've seen wolves before that is a totally different animal than I've never seen a wolf in the wild though I did well I saw one but it was like running across the road at a distance and it was dusk Yeah, it was that was in Alberta. There's a lot of wolves up there. But that I've never seen, well I've never like looked in one's eyes and it's like these aren't even that old. Right. You know they were more than six months old but they were almost a hundred pounds already. Yeah. And they have this look in their eye. And you can see they're bigger, they're more muscular, and you see that that coat, the Dire Wolf

coat. Extraordinary. The mane that they have, it's very, it's really incredible. And then there's a little female, Khaleesi. Yes. She's adorable. And she is like a puppy right now. You were able to hold her? She's adorable, yes. She nibbles on your fingers. She's a little thing. But she's, you know, one day gonna be 140 pounds. You can't get anywhere near her. Right. Which is really crazy. Yeah. I'm glad you got to see the boys before. They were probably already a little bit standoffish. Yeah. Especially compared to kaweezie. Yeah. They're standoffish. They get fairly close though within like 20 feet of you checking you out. They pee all over the place, you know, marking their territory.

It's just so strange to see an animal in the flesh that didn't exist, uh, you know, for 10,000 years. It's amazing. I was there for Khaleesi's birth and I, people were asking me afterward, how did that feel? And I just, you can't even describe it. This moment when she was born and then she screamed, she had this cry, this scream. I have it on my phone actually, I can play it for you.

But it was just such a, I don't know, it's this awe. I think this is one of the best things about the de-extinction work and the species preservation work that Colossal is doing, is that we live in such a crazy time. People don't often have an opportunity to feel genuine awe about something. And this is one of the things that people get about going out, going hunting, get out and going and spending time in the woods or going and experiencing something that they wouldn't normally experience is this way to feel genuine wonder

and excitement and enthusiasm and Khaleesi's birth. I wasn't there for the birth of the boys. I was in the UK at a conference and it was very sad and I had COVID and I was asleep and trying to recover. And the next morning I woke up and there were like 150 text messages on my phone from Ben going, what the fuck are you doing? Where are you? Why are you not responding? And I'm like, oh my god, I've missed this moment.

So I made sure that I was there, present for Khaleesi, and I'm glad I was, because what an amazing... I'm glad you got to see them. I'm glad I got to see them too. It's really a crazy experience. I felt very fortunate just to be in their presence and also very conflicted by it all. This is so odd. Is this the beginning? Are we gonna bring back everything?

Is that a good thing? Are things supposed to go extinct? Are we supposed to just bring back everything that's ever lived? At what point do we draw the line? All these thoughts in my head, why are human beings the deciders of what lives and dies? Like, are we...do we have an arrogance because of our relative intellect that we think that

we should be able to make these kind of decisions and not understand the comprehensive effect that it has on the entire ecosystem? And we know what happens with invasive species. When invasive species come into new territories, they destroy everything. It's like Florida is an amazing example of that. Florida is so crazy. It is, I mean, it is Florida. You know, I mean, like when you think of Florida, you think like Florida man.

So the only state that you can say like the name of the state and then a man and everybody's like, what did he do? But that's Florida ecologically. Like the entire center of the Everglades is infested with Burmese pythons. Yeah. Did you see that there is a competition every year to go out and kill as many as they can and there's a monetary reward for people who kill. I think it's the most or maybe the biggest. There's something like this. Even that's not going to put it down.

No, it doesn't at all. People kill and during this competition, they kill hundreds, maybe thousands of these snakes and it doesn't even touch them. There's an estimate of a half a million. They think there might be a half a million there. And there's a guy that's been on this podcast for calls himself Python cowboy. He's quite a character. And didn't he give us a head? We got a head laying around here, right?

You got it over there? That Python head. But that that dude he has been catching them He's his dogs the dogs find where the nests are and the video of these things, you know You're pulling out this 15 16 17. I think he's got as big as like an 18 foot long snake Wow, there are hundreds of pounds. They're enormous and they swallowed the deer and Alligators, they're eating alligator, because alligators are doing great. That's one thing I don't mind them doing. We need something that's hot in alligators.

That's another problem in Florida. It's infested with alligators as well. And they used to be on the endangered species list. When I lived there, they were on the endangered species list. One of the class of 1967, right? The first species to be officially listed. Why did they list them? Because they were almost gone at that point. How did they do that?

Like, I can't imagine that you could do that now, that you could get them to the point of extinction now, because they're so hard to find and they're everywhere. Maybe it was just- I don't want to say they're so hard to find, but I mean, when they get in the water, you know, like, you're not going to get all of them. Yeah. Like, how are you killing all of them? I was watching, you know, there's a show, I don't know where it's on, but it's a show that's called Florida

Man. I was watching it on flight the other day, seriously. And it goes through interactions that Florida men have, and one of them is about a dude who was kind of lost in his life, and he climbed over a fence that he shouldn't have climbed over and went for a swim in a lake, and then had an alligator bit off his arm. That is the story, That's that particular. Oh, I saw that guy in the news. That's the guy that like he had to walk like for a whole day with like one arm.

I don't know. I remember there was a guy who what I mean, I don't know. There's probably hundreds of stories like this. In this video, and I was trying to sleep so I'm probably wrong. In this video, he laid on the side of the lake, like probably bleeding to death when an alligator that was in the shape of his mom, I think, came up to him and told him he had to get his ass up and move or he was going to die. And he was like, okay mom, I'll do that. Oh boy. He was probably not sober. It was blood loss at that point. Sure. And then also whatever contributed to making him climb that fence in the first place. Right. I won't play the video but

there you go. Is that the dude? I mean this is this is not the show she's watching is on Netflix I think. Is it? This is a similar thing that did happen a month ago here's the video of it. The one that was the show that was about... The show was about something that happened years ago. years ago for them to be able to make it. But yeah, I mean, how many people in Florida? I bet it happens all the time. Yeah, right? I mean, it's Florida. They are huge. Yeah. Now they're in Georgia too, right? Oh, they're in Texas. Yeah, Texas. They're here. Yeah, they find them. And the golf courses in Florida, like, good luck playing golf out there. Are you crazy? You're playing golf in Jurassic Park. I'm sure you've seen the videos.

There's one amazing video of this huge alligator. It's like a 14-footer, and it's walking across this golf course, and it looks like a dinosaur because it's not walking like with its dragging its belly on the ground like they sometimes do. It's kind of puffed up. There it is. Look at that. Holy, oh my God, that's wild. That is so big. Look at the size of that thing.

And you're out there playing golf. You're like, you see that guy and you know that they can run fast. Yeah, they run like 30 miles an hour. Yeah, and they run faster. Look at this dork. This dork can't run 10 miles an hour. Florida man. Yeah, that's totally a Florida man. Give me give me a selfie for the Facebook Get right up on that thing and you know, there's a lot of them there, too I mean they say that it pretty much any Undisturbed body of water likely has an alligator in it now. So what ate them? That's a good question Back in the day, they probably just ate each other, you know, they cannibalize each other Maybe they're gonna do that too

I mean sure they probably do probably have to at a certain point in time. What are the snakes going to eat? Snakes have wiped out 90% of the mammals in the Everglades. And they're terrible for birds too. Oh yeah, for everything. Ground nesting birds, anything. Anything they can get a hold of. I mean, if there's a half a million of them, that is a killing population of extraordinary proportions. I mean, half a million things that could eat a deer, you know, there's no skunks left, there's everything, raccoons, they're all gone. Everything's missing. But this is exactly why we need these technologies that we're trying to develop a colossal, you know, where we're

not just bringing species back to life, right? We're a species preservation company. It is a sales pitch, but birds, whenever I think about birds, I think of this, right? We know that there are things that we can do to help mammals to adapt to rapid changes in their habitat, right? We can do things like the Florida Panthers. One of the things that we did to save Florida Panthers

from becoming extinct was we introduced Panthers from Texas Which are closest genetically and geographically to Florida Panthers They were probably connected at some point until humans created stuff that meant that they couldn't go back and forth and When Texas Panthers were introduced in the mid 1990s that population recovered they stopped they had a Disorder called cryptorchidism where their testicles wouldn't descend or only one would descend. They had all sorts of heart problems. They had- Is that because there's a small breeding population?

Yeah, because there were very few of them and so- No genetic diversity. The choice was to mate with your family. That's it. Right? And things want to survive so they do. So you get these highly inbred populations, and people fixed it by moving an animal from one population to another, introducing new genetic diversity. It's called genetic rescue, right? And that's a great way of bringing diversity back into a population. It's what we're trying to do with our red wolf project. Red wolves are one of the most endangered wolf species in the world. They're the only endemic American wolf and they are nearly extinct. There's a

successful captive breeding program and a few years ago some of the people that we work with at Colossal Woman called Brigitte von Holt who's at Princeton who's a friend of mine, she was working and discovered because people were sending her photos. See this is why you have to pay attention to people who you think might be crazy when they send you pictures of things. Look at this cool, crazy thing that I think I found. You shouldn't just discount it. I'm the person who has tested insulation

that somebody told me Bigfoot peed on and participated in it. Because if it's real, I wanna be the person who finds it, right? Right. So Bridget says this guy who lives down in the coast of Louisiana sent her a picture of an animal that she's like, that is not a wolf and it is not a coyote and I don't know what it is and it's crazy. And she looked

at it and she goes, yeah, it's not. It's something else. It's something in between those. And so she tested it and found that it has a ton of DNA ancestry from red wolves. And they're hybridized a little bit with coyotes, but all red wolves are hybridized a little bit with coyotes. Canids are always hybridizing with each other. We know that because there are wolves that are black because black gene for wolves got into the wolf population because a domestic dog had his way with a wolf in heat, right? That's how that allele got into the wolf population because a domestic dog had his way with a wolf in heat, right? That's how that allele got into that population. So we know canids do this all the time.

And she was like, this is so cool because this captive breeding population was established with just a few founder individuals. And the team working with them are doing a great job trying to maximize genetic diversity by picking who's going to pair with who to keep all that diversity there, but it's still just a few individuals. So they are going to lose genetic diversity. It's just how it works. But if we can bring other individuals in from this population, that's a way of concentrating more diversity, better able to pick which parts are red wolf, either by breeding individuals or by editing their DNA, which is technology that we developed on the path to dire wolf.

And we can actually help this population to survive. So there are ways that we can do this for mammals that are going to have really amazing consequences for the way we can protect biodiversity. Well, that's fascinating for things like red wolves and things like that, but What you know, what do you like? When you think of like the python problem in Florida, I heard the worst idea the worst idea They were talking about introducing honey badgers Honey badgers because they eat snakes. I Mean, I don't know if this was a serious idea because we have never as a species humans

Introduced a thing to try to control a thing and that thing that we introduced just went horribly wrong. We've never done that before, right Australia? Right, Australia's a wreck. They have a terrible feral cat problem. Yeah. And in Hawaii they have these giant African land snails. Oh yeah, I've heard of those. Yeah. That they introduced this thing called a rosy wolf snail that they were going to get to eat the giant African land snails. But instead the rosy wolf snail prefers the taste of native endemic Hawaiian snails. And so the rosy wolf snail is leaving the giant snails alone. And they're big. Have you seen one of those?

I don't think I have. A giant African land snail. It's worth looking at it. Did they come over on cargo ships or something? I think we, I think people introduced them for some reason that I can't remember what it was. Oh great. Yeah, so we have a good history of doing this kind of thing. Is it for giant-esque cargo? Whoa! Right. Whoa! Can they eat those? Are those delicious? I think people can eat them probably, but they eat everything from all of the vegetation to the other snails To plaster, you know, they'll eat their way through infrastructure that people have built. Oh great. Yeah. Oh great

Yeah, so we introduced these little things rosy wolf snails to try to control them But instead they're killing all the endemic snails. So We know yeah, I hope they don't bring honey badgers to Florida But I mean, you know, I don't even know if this article is reading was a serious article But it was just like that sounds like something that someone would because you know They have they're really good at killing snakes. Like that's what they like to do. They kill cobras and they have an Unbelievably resilient body like they can tolerate getting bit by lions. I mean they're freaks They're really weird animals like honey badgers and they just really do you right?

I remember my kids were little watching the wildcrats There was a wild episode about honey badgers how they were all cute when they were babies because they were hiding in camouflage Yeah, yeah, maybe when their babies are cute. They're pretty ferocious. Yeah. Yeah, there's a lot of ring Yeah, yeah, very similar to Wolverine's. Yeah, like I think they're cute. They're pretty ferocious. Yeah? Yeah, there's a lot of- Like a wolverine. Yeah, very similar to wolverines. Yeah. I think they're all in the same family, right?

Yeah, there he is. Look at that face. I think they look very cute. Look at that face, just big old deadly snake, and that's his lunch. And they get bit all the time, and they just like, they get sick, pass out for a couple minutes, and then recover and kill a snake. That's amazing. Yeah, they're ferocious little animals.

So have people been able to understand better antivenom properties from studying them? That's a really good... Look at that face. Oh my God. He looks vicious. That is such a crazy animal. That pattern on the coat is really beautiful. Oh, they're wild looking.

They're wild looking. I just hope they don't bring them into Florida because it sounds like someone's going to do it. You know, like it sounds like someone's going to do it. It sounds like a Florida idea. Have you heard about the hippo solution in the early 20th century? No. No. This is a great sort of American history story because our country is replete with people

with brilliant ideas. And in the early 20th century when the land in the West was not doing so well, been overgrazed, there were too many cattle, and there was this thing called the meat question. It was the thing of the day, the meat question. People were talking about, how are we going to survive if there's not enough cattle? Maybe we're going to have to eat our dogs. And at the same time, there was a problem in the Mississippi and other places where the, I think it was the World Fair people had the

Brought New Orleans who was the host city of the I think in Japan. They brought New Orleans this Water hyacinth this water little tiny beautiful flower to as a gift and they loved it And so they planted it everywhere and it just grew like absolute crazy and was choking up the river like ships couldn't get through because of this like matted where people were like putting oil on it to get it to sink and trying to light it on fire and nothing would happen. And this team of people that included a congressman from Louisiana came up with a solution for both problems at once, and that was that they were going to import hippos from Africa into Louisiana to live on the bayous. They would eat the plant, this water hyacinth

thing, and then we could eat them. And that was going to be the perfect solution to both of these problems. Yeah. How did that get stopped? It was an accident. So it was, it's actually a fun story. You should, you should look it up and read the

whole story because it involved these two guys. Um, one, one of them was the guy who was the whole story because it involved these two guys. One of them was the guy who was the inspiration for the Boy Scouts of America. Another guy was like a con man who had worked as a pimp and a journalist and all these other things and they had actually been employed during the Boer Wars to kill each other. But they came together on part of this congressman's team. The scout thought it was a great idea. He wanted people to bring in all sorts of animals from Africa and put them in national

parks so that people would want to go to national parks because they could hunt them and they could and that would have more reason for people to want to support the idea of national parks at the time, which is great. You know, this utility of nature. It seems weird compared to how we think of it now, but I think this is really it's really important and it was really important part of the way we got conservation legislation in the US. So he was excited about this. And then the congress, when he was pulling together the team of people that he

wanted to be on his side for this, he went to a show that this other guy, the sort of con man, traveling salesman, pimp, escape artist dude, was having about how he was an intrepid explorer and he was like, that guy is an expert as well. He can also be on my team. And they testified in front of Congress and they asked questions like, you know, how do you know that they're safe? How do you know that they're tamed? This con man, he was like, well, you know, there's plenty of evidence that you can even feed them from a baby's bottle with no evidence whatsoever. Right? Just everybody was like, yeah, awesome. Even the New York Times was completely behind it. they published an editorial

Talking about they called the hippos Lake Cow bacon. Yeah Here was this early 20th century Lake cow bacon yeah, everybody was like this is it this is what's gonna Yeah, Teddy Roosevelt Yeah, well it didn't it didn't go up for a vote. How the US almost became a nation of hippo ranchers. Oh my god. Failed House Bill sought to increase the availability of low-cost meat by importing the hippopotamus that would be killed to make Lake Cow bacon. Yeah, it's brilliant. This is such a... It's so funny. But it's not fair to call it failed because it didn't fail.

It never came up for a vote. So they had testified in front of Congress too late for it to come up to a vote that year and then just other shit happened and people stopped paying attention. That's it? It just went away? Wow. Yeah. So near miss on the hippos.

Well, they kill more people in Africa than any other mammal, right? Yeah. Well, and now we know that they're good at becoming invasive. You saw there's hippos that live now in Colombia because of Pablo Escobar. Nobody knew what to do with them. Yeah, and they started off with just a handful of them, and now there's like dozens of them down there. What are they doing about that?

Nothing. I think they keep rounding them up and putting them back on his property. What can you do? How much property did he have up there? I don't know the answer to that. I think they keep rounding them up and putting them back on his property. Like what can you do? Sometimes they escape. How much property did he have up there? I don't know the answer to that. It's so crazy that you just have hippos and then they just get loose and now that Columbia has hippos.

He took them there on purpose though, just like we wanted to bring them here. Can you imagine how bad that would be though? And I mean, do people want hippos? Well that's the wild boars in the United States. That's William Randolph Hearst. William Randolph Hearst wanted wild pigs on his property. And so he imported them from, I think from, I don't remember, it was Russia or somewhere in Europe. And then these wild pigs have now populated all through California. I mean, they're all over the place now. Yeah, that's crazy. We did have wild pigs around the US at some point

probably not the same thing right? Were there wild pigs? That's a good question. I think they came over on boats with explorers you know and I know William Randolph Hearst. All the ones around like the northern California area I think all of those are the remnants of the William Randolph Hearst pigs. Yeah. They think. We don't see them in Alaska, Yukon, where we find all these big stashes of bones coming out of permafrost. So it's probably not that they came over like that. We find bison and horses and manes. Mostly bison. Where did the wild boars emanate from? Like what's their original country of origin? I think, well, I have a friend who works on domestication of pigs, and they've published

a bunch of different papers that are always contradicting each other. He gave a hilarious talk at a meeting I was at last week about how he keeps saying something different as a way of, you know, keeping to publish more papers. He was just being nice about how he's open to changing his mind with new data, which I think is a valued trait in a scientist. But yeah, so Southeast Asia or around Asia, I think, is the origin, or at least the domestication. And normally things are domesticated around where they were. Well, they're the weirdest animal, right? Because the domestic ones will become, they change, they morph when they go feral really

quickly. I think it's like they start within like six weeks. I mean, this is the way evolution works, right? You know, something has a particular suite of traits The testimony of the when this was going on. This is the guy who presented this thing he's talking about pigs right here where they're gonna bring them from northern Manchuria because if Were they the most delicious pigs? They're also talking about bringing in rhinos. Yeah, I think they did bring in camels in like 1853. Well, we had camels.

There were North American camels that were here during the ice ages. This is a bad test or something. This is 1853? They're talking about bringing antelopes in and they asked like, are they easily tamed or domesticated? He's like, they're very easily tamed. That's Irwin. So this is a guy who worked for the, I what became the USDA but he was in charge of apples

But he was really dedicated to trying to solve this meat problem and he saw Importing African animals and animals from other places as the real solution to this. Yeah. Well, they've definitely done that in Texas Texas is overrun with African animals. Well, all the private ranches Yeah filled with elans Neil guy Guy, and Wildebeest. We used to have so many cool animals here that all went extinct at the end of the Ice Age, so why not? I mean, we had mammoths. Why shouldn't we have elephants?

I know, but isn't it weird? But it's again, that's the same argument. You bring in an invasive species. Is it invasive though, if it used to live here? Well, it's invasive in a sense that the wolves that are in Colorado right now that are eating all the cattle are kind of invasive. Yeah I mean right. They're not invasive because they do live I mean there are wolves actually just have moved into the San Juans I think I think documented like natural migration as opposed to the reintroduction I think

there was something I read about that yesterday But the wolves that they've introduced to like outside of Aspen in particular I have a friend who has a ranch out there and I posted about it on Instagram He actually sent me some more pictures yesterday And I was gonna post about it, but so much crazy stuff was happening in LA I'm like, there's not time to talk about like wolf problems But the they they're just killing calves and eating their liver. They're not even that hungry. They're just eating the tasty parts and leaving these calves alone. And these people are on a 24-hour run ragged, you know, they have these teams of guys that

have to patrol the area 24 hours a day to try to scare off the wolves and they're not allowed to shoot them and you know they spent millions of dollars bringing them there and they're just eating cattle. Yeah I imagine it's really devastating to see something like that happening and know that somebody else made this decision and that you who actually experience it weren't I mean I imagine the people who voted for that. I wonder what they imagined. Well, it's ballot box biology, right? You get a bunch of people that live in the cities

that don't have a lot of experience in nature and wild ecosystems. And then you introduce this idea, we're going to bring wolves back to their native habitat. Oh, that sounds amazing. What they're not telling you is like this, with this rancher told me is that first of all the original wolves that were introduced into Colorado were wolves that were taken from Oregon because these wolves were preying on cattle So they already had a taste exactly and they already had habits and so then they brought them into Colorado where they Start preying on cattle and so then they moved them from this area where they were preying on cattle. And so then they moved them from this area where they were preying on cattle and put them outside of Aspen where they...

Prey on cattle. Start preying on cattle. It's just stupid. Yeah. And again, it's not biologists, it's not their idea. It's ballot box biology. This is why. It's all being instigated by the Colorado governor.

It's so important to actually talk to wildlife biologists and ecologists. We can see from Yellowstone how important having this keystone predator is in ecosystems where they can be and where there is space for them. But the land is not the same as everywhere as it is in Yellowstone. We need to be able to make... When I was at Santa Cruz, I taught an introductory biology class for non-majors, where my goal was to give the students tools to be able to think on their own, which is

harder than you might imagine. And their midterm exam was a debate, and the topic of the debate was that wolves should be introduced into California. Why not New York City? Let's go. Put them everywhere they used to be. I mean, this is where it gets silly. It's like when you're dealing with people that have cattle ranches And this is their entire livelihood and all they're doing now is just compensating them for the calves that get killed and then so you

Have a less output every year. So it's like the whole thing is crazy They were already on their way to do a natural migration into Colorado, right? And it would have been different wolves. Yes, it would have been different size wolves too. Because I think there's also like some of the wolves that are being introduced, they're introduced from British Columbia, or they're being introduced from Alberta

or somewhere up there. I think those ones that came into Yellowstone. Like the Yellowstone thing is cool, right? It's been a few decades now, people have kind of like come to this sort of equilibrium, you know? People recognize that there was an overpopulation of elk for sure. I mean, they used to have these hunting seasons where they would hunt them in the snow in

the winter because there were so many of them. They wanted you to just be able to pick them out and just shoot them for meat. Because they really didn't have the resources because they didn't have the apex predators. Because a lion can only eat so many of them. So mountain lions weren't really putting the dent in the population that a pack of intelligent hunting cooperative animals like wolves could do. So they brought it back and it's relatively successful. They've knocked the population of elk down more than 40 percent, but that's probably good.

I mean, not for the people that hunt elk, they're really mad. But wolves are cool. It's cool to have them around. But Montana is very different than Aspen. It's very different in the mountains of Montana, you see a wolf versus in someone's cattle ranch in Aspen. Right. This is like, this is stupid. Why did you do this?

But what's interesting, this class that I took, it was a debate that I taught, sorry. It was a debate. And what I made them do was assume roles of a rancher, a politician, a conservationist, and I had several different roles. And then I randomly assigned whether they were pro or con. And they had a couple of weeks to figure out what their debate was going to be, and I took a vote before the debate. And as you might expect for 18-year-olds in California, you say at the beginning, should wolves be introduced?

100% yes. Right. Right. They do this debate, and I did it four years in a row, and every year after they had to do this, after they had to put themselves in somebody else's shoes and I did it four years in a row and every year after they had to do this, after they had to put themselves in somebody else's shoes and think about it from their perspective, it would shift and the majority of people would be like yeah no it's a bad idea. I think if you give people the tools to be able to think they can imagine themselves in a different scenario and we need to do

that. We need to be arming people with thoughtfulness rather than jumping to a conclusion Yeah, and also Ballot box biology. It's like if you but everybody's gonna vote so right But you shouldn't be able to vote on things that you're not educated in Yeah, it's like if you allow people to vote on things that have tremendous Consequences to the ecosystem like a reintroduction of an apex predator. And they don't understand those consequences. They just have this very utopian idea of what it means to bring back wolves. Look, I love them.

I think they're amazing animals. It's just like putting them in, you know, Calabasas is probably not the best idea. Putting them where people live, they're going to eat pets. They're going to eat a lot of things that are penned up, whether they're sheep or goats or whatever, whatever people have that they can get out easily. They're not going to chase down a herd of elk. That's hard. Well, they're biology, right? They're not, they're making decisions on where they can find their next meal. We're not planning on rewilding dire wolves just to put that out there.

Plus you've met Khaleesi. I don't think she would be. I bet she will in a couple of years. Yeah, maybe so. But right now. In a couple of years she'll freak you out. She kind of freaks me out already when you look at her. Her eyes are so intense. They're so intense.

When you look into a predator's eyes, there's something about it. You realize, oh my God, I'm like a water balloon. We're just so weak and soft. Yeah, we've been putting together, not because we're not going to release them, the next step for their lives is to study them and see how they're changed by their DNA being modified, measure things like their gene expression, their growth,

their health span, their lifespan, learn the consequences of the work that we're doing, learn how they interact with the habitat. Introduce Khaleesi to her brothers and the next animals that we make into that pack to make a small pack, but they will stay on that secure, expansive ecological preserve that you were fortunate enough to see. Yes. And you're not going to let them breed?

No. The plan is not to let them breed. How will you prevent them from breeding? Well, at the moment, they're separated, but we'll probably use subcutaneous, you know, you can put a hormonal contraceptive. Like a birth control patch. There's been some ideas of maybe... so we don't want to castrate them, which would obviously be a way to stop it, but because we want them to be able to reach their full size, because we want to know what that it, but because we want them to be able to reach their full size because we want to know what that would be.

And we want them to be able to have the hormones to be able to do that. But they will be controlled. We track them. There's cameras on them all the time. There's three separate layers of fencing to keep them in. We know exactly where they are. They couldn't get a splinter without a camera somewhere seeing it, and we know exactly what's going on with them.

So yeah, we'll... That sounds like a scene in Jurassic Park. We have it totally under control. I've seen that scene, yes. Don't worry, we have cameras upon cameras. No, I was- do I sound like the scientist? No, you don't. I kind of do, actually. I was in Mauritius.

Which scientist? You know, Jeff Goldblum was the scientist that got it. I'm Henry Wu, right? I'm the chief scientist, right? So I'm a good guy for now. Right. Good guy for now. But he becomes a bad guy in the future, right? So I'm looking forward to my evil transition. I'm not. We're not making dinosaurs. But there were other cool animals that we have DNA for. We have a... I heard you talking about the American cheetah.

Yes. So we have two high quality genome sequences from American cheetah. Yes. So, I have, we have two high quality genome sequences from American cheetah. Wow. We want them back to help with our population problems. So let's get to the criticisms because there's people that are saying that these are not dire wolves, that what you've done is just manipulate the DNA of a gray wolf. They are dire wolves because we have manipulated the DNA of gray wolves.

We took dire wolf genome sequences from animals, one animal that lived 72,000 years ago and one animal that lived 13,000 years ago, and we lined them up next to each other and figured out what it is that makes a dire wolf a dire wolf And then we used the tools of genome engineering to bring those traits back in Romulus Remus and Khaleesi that are three dire wolves that are alive now And that has created these animals that you saw that are bigger and they're stronger and they have that Dire wolf coat and that's a cool thing too. That coat, the light coat color that you see, was something that we absolutely could not have known

without the ancient DNA because no one has ever seen a direwolf. When we published a paper before I joined Colossal many years ago that was about direwolf evolution, we had a paleo artist reconstruct what direwolves looked like and they made them red and reddy brown. And that's because so many other animals seem to be reddy brown, like mammoths are, neanderthals seem to have had red hair and so we thought, sure, why not? We didn't know because we hadn't sequenced the part of their genome that we could use to see what color their coats were. But both of these two animals that we had higher coverage DNA from had gene variants in genes that are

associated with pigmentation, how our coats, the hair color and eye color and things like that, that suggested they had light colored coats. And so we thought, that's cool. We'll have that as one of our key dire wolf traits that we're bringing back. Is it possible that it's like other wolves where there's a variation, but you would only sequence the DNA of ones that had white? It's possible, yeah. And I'm sure there were different colors. But it's interesting to me that two animals that lived so far apart from each other in

time and geography would both have this light color coat. So maybe it wasn't that every dire wolf had a light coat, but it must have been a predominant color in the population. What was the environment in which they lived? So if they lived 13,000 years ago, you're talking about the ice age, right? Do you think that that's why they had white hair? It's possible. Both of these animals were from northern part of their range where it would have been colder.

They did live through previous interglacial periods. 125,000 years ago, it was as warm as it is today or even warmer with predicted to be no ice at the poles. And also we know dire wolves were really common around the La Brea tar pits in Los Angeles. We haven't been able to get any DNA out of anything from La Brea. That would be an amazing discovery. Does the tar just destroys everything? Don't know if it destroys it or if it gets into the bone in a way that we can't get the DNA out. So somehow inhibiting the recovery of the DNA, we'll get there.

Someday we'll figure it out and that's going to open up a lot of really cool animals. It kind of makes sense that like polar bears, having that white color would... Polar bears actually have... It's clear, right? Yeah. They have... Their hair is long and it's clear. That's why polar bears...

Have you seen those pictures of bears in zoos where they look polar bears in zoos they look green. No. Oh they get covered in moss? It grows in the the hair is hollow. Whoa. And so if they're too wet and not cold enough they can turn this is like weird. Oh they have mold. Inside their hair. Oh wow. But it just makes sense that them being that color would have an evolutionary advantage for hunting because you're in something that's completely white and you don't see like a grizzly bear, you'd see like, oh, look at that dark blob that's moving towards us. We did some work in my academic lab where we discovered that polar bears and brown bears

hybridize with each other. This is one of those funny stories about academia with a scarcity mindset there where we submit a grant proposal and we say, hey, we have this really cool observation that polar bears and brown bears hybridized during the last Ice Age when they overlap with each other and it gets rejected because they're like, that's dumb, we know that doesn't happen. And then we found another hybrid polar bear from the previous interglacial and then there's evidence that they're hybridizing today. Yeah, they find them today. And the hybrids go out and do this. Yeah. So whenever they overlap geographically, they breed. But what's interesting about this is that we always find the hybrids living like

brown bears, even though it's probably that the mom is a polar bear. Because a brown bear boy will wake up, you know, from hibernation and go out onto polar bear territory to scavenge for food. And a polar bear female is an induced ovulator, whereas brown bear females are seasonal. So a polar bear female will ovulate in the presence of a male. So the male comes up to her and will mate her. The other way around, if a polar bear male had encountered a brown bear female, he's probably more likely to eat her than to mate her.

But that's weird then. So why do we always find the hybrids living with brown bears instead of living with polar bears? And the polar bear biologists who we've worked with, I've worked a lot of time with Ian Sterling who's a fantastic polar bear biologist from Canadian wildlife. And his hypothesis is straightforward, that they can't successfully hunt seals if they don't have that white fur. Ah, completely makes sense.

It does, right? Because they have that ability to swim and they dive under the water. And they're also like really clever and how they use those ice shelves and swim from one ice shelf to another. Yeah but they hide in I mean they even have those things where they cover their nose the with their hand the black nose with their hand because the black nose I know it's insane right? Biology is cool. It is cool it's cool like to think of like how they became successful doing that. Who figured that out? How do they have the self-awareness to know that the end of their nose is dark and that other animals can see it?

But they also hybridize just given the chance to do so, right? Because biology doesn't recognize species concepts, right? Biology doesn't care that that animal is called a brown bear by us and that animal is called a polar bear. They run into each other. They're like, cool, just like our Neanderthal ancestors. Are those hybrids, are they fertile? Can they have babies? Yes, this is actually how we discovered it because we found that the place where brown bears hybridized with polar bears during the last ice age was probably the ABC islands off the coast of Alaska because the ice was that far south at the peak of the last ice age was probably the ABC Islands off the coast of Alaska because the ice was that far south at the peak of the last ice age and brown bear boys would move onto the islands

as the habitat got better where they encountered these populations of polar bears that had been stranded there as the ice receded pretty much and so they hybridized there and all brown bears in North America today have ancestry from that admixture with polar bears. Geez. Wow. That's so fascinating. Yeah. It's just like how we all have ancestry from mixing with Neanderthals. Look at that. Is that from the German zoo? I...

Because there's a couple of bears at it. But that really looks like a hybrid, doesn't it? Yeah. Literally, there's a lot of traits of both of them. Yeah. It's impressive. Bears are some of the most fascinating animals ever. Yeah, it's just an incredible animal. So that's it. It's really, I'm really glad you said it that way, that nature doesn't know that there's a polar bear and a brown bear.

Why would it? You're right. It's just our definitions. Is this part of the problem with the criticism of the science is that we are being very specific about what we're calling these things based on our own definitions that we've all agreed upon? Yeah. But that the true nature of genes is that there's this like proliferation and fluctuation and all these animals breed with each other

and it's like... It's kind of that, but it's also that we haven't agreed, right? So there's this group of academic scientists who are trying to say, trying to grasp so tightly to this very precise definition of a species as having to do with DNA, how much DNA matches something else. But that is, and it's interesting, I think the reason that we keep having this conversation is because it's genuinely interesting to talk about species concepts. We have come up with, you know, dozens of different species

concepts and they're all for a particular purpose. You know, if I am wanting to have a conversation about dinosaur fossils or anything that's a fossil, I'm going to use the morphological species concept because that's all I've got. I'm going to compare the shape of this bone with the shape of this bone and if they're similar enough to my trained eye, I'm gonna call that a species. I saw you had a bison priscus, I'm going to say, skull out there. This is, that's from the Alaska?

That's from the boneyard, yeah. Step bison. Yeah, step bison. Bison priscus. Or bison crassicornis, bison occidentalis, bison aliskenis, bison, I could go on forever I, you know, this is, the naming of bison was like sport in the 18th, 19th 19th centuries mostly 19 Did you go to the bone lab the boneyard? I haven't I've been to his I didn't go with Ben But I've been working up in that part of the world for 30 years We spend a lot of time working at gold mines outside of Dawson City in have you been to Dawson City? No, it's amazing like it's an old-timey gold town dirt roads wooden sidewalks like the buildings are all crooked

because the the fire is burned at one end and it melts the permafrost underneath that it goes well it's where I learned what you're supposed to do when a fight breaks out in the bar that you've gone into what are you supposed to do grab your beer right no get out of your beer is gonna get knocked over I'm not leaving you'm not leaving. You're not leaving when a pipe breaks out? Not in Dawson City. There's mosquitoes outside.

No, it's... I would tell you to leave. No, it's a weird place. Unless there are women. Women fighting don't scare me as much as men fighting. But then women can pull out guns. That's true. But this is Canada, so less likely for that to happen than in Alaska. But there have been weird things happen there. You go out to the bars in Dawson City.

Why am I telling these stories? This is ridiculous. You go to the bars in Dawson City and they still have this thing where there's the bell. And if you ring the bell, the person who's running the bell is buying a round for everybody who's in the bar. And you learn after you've been there for a while that a person is only ringing that bell because he wants the right to talk to everybody who's in there because he wants to fight with somebody, right? This is somebody who's like a diamond driller who's just got paid in cash for the first time and he's like now I want to fuck somebody up, right? So he comes in. Really? That's what they want to do when they get paid? Rings the bell and then goes from table to table sitting around with people and we

Did like nerdy scientist paleo geneticist it in the corner are trying to just be super nice Canadians like talking to these people Like I don't want to fight He's just looking to fight him with someone just just looking to fight boy. Yeah, it's a weird part of the world It's it's it's fun place to work. But anyway, I digress. There's gold mines like the site outside Fairbanks that are super productive like this, and every one of the miners out there has this cool collection. Not nearly as cool as his, but because he's got so much land, they've been collecting it for such a long time. I heard those great stories about how he donated material to the American Museum.

Well, it was previous owners of his property. Right. Right. That's the case, right. And they dumped it in the East River. And so they denied dumping it in the East River. So then they hired these guys to go and dive for it. And John Reeves told everybody where it was. I don't know if he hired him or just told them. So these guys dove in the East River. They found step bison, bones, jaw fragments, all sorts of different... Do you know what I think is great about that story? I really like it, right?

Because I'm sure it's true because they have so much of that material at the American Museum. When I started working on bison, and I've worked on bison for 30 years, right? When I started working on bison, getting back to the species concept, I was trying to figure out if the DNA mapped to these species names, and they've got a fantastic collection at the AMNH, but a lot of it is crap. You know, there's so much bone there, broken pieces or other pieces, and you get to the point where you're like, what the hell am I going to do with this? Now, they shouldn't have dumped it in the river, obviously, that's dumb. But he is going to get the last laugh. He won't know because

he'll be long dead. But in 10,000000 years when the paleontologists of the future are looking in that river, they're gonna be like what the fuck Right, cuz there's like tons of it out there What happened here? What is that guy's name dirty water dawn? Is that his name? This one guy who's one of the divers he's found multiple pieces. Yeah, and sure it's there Yeah, and they probably didn't mean anything terrible by it. They were just like... Well, who knows? Those people aren't even around anymore. I think this was in the 20s, wasn't it? Probably around the 50s. That was when most of the collection came from. There was a ton of gold mining activity in the 50s and 60s around Fairbanks. So what they have

found on John's property that's so spectacular is that it's really only a few acres that he's getting all this stuff from, which makes you question, like, how did all these animals die off in mass in this very small area where you've got warehouses filled with bones and tusks? Yeah. Near Dawson, it's called the Klondike region, you have this really fine glacial silt, and that settles in different places in differentilt, and that settles in different places in different quantities, and it settles really quickly. So you get this really fast,

thick buildup of this really fine silt that preserves the bones really well. So when we go, the gold miners are, they're placer mining, so they're taking these high pressure water hoses and washing away this frozen dirt, then they let it thaw for a bit, and then they wash away the next layer. They're trying to get to the gold-bearing gravel that's underneath. But while they're doing that, literally thousands, tens of thousands of bones come out of there. And in some places, it's more rich, more intense than others, but it's there. I've taken students up there, and they're all mopey because of the mosquitoes, and they're mopey because they're 19. And they're like, oh, we're never going to find anything. They jump out of the're 19 and they're like, oh we're never gonna find anything They jump out of the trucks and they're like, holy shit. Is that a mammoth tooth? Like yeah, that's a mammoth tooth

Yeah, is that what you brought? That's what I brought you. Yeah, this is a it's a fossil. This is from South Carolina That's from South Carolina and it's a fossil you can see it's fossil. I know they like knife handles out of this stuff Which seems to me it's kind of gross. Yeah that has handles out of this stuff, which seems to me, it's kind of gross. Yeah, that has... Oh, that's your logo on it. Of course it's branded and it's colossal, you know? Yes, our logo. But yeah, mammoths...

Do you know the story about our founding fathers and mammoths? No. Yeah. So Thomas Jefferson was obsessed with mammoths How did he even know about them? So they were there were it's probably mastodons because it was these teeth that were melting out of the salt licks and things like that And in the part of the United States, but he was he was obsessed with him He was getting his friends to to mail him teeth that he was finding and he was This is a funny story. Let me see if I can get it right. You should look this up too because it's hilarious.

How mammoths made America great before and now when we bring our mammoth back, we're going to do it again. So there was a guy in France who was writing a series of books. He was like Comte de Buffon. Comte de Buffon I think was his name. I'm terrible with French so I probably did it wrong. But he was writing a series of books about natural history and the fifth I think of his books was called The Theory of American Degeneracy and when it was essentially about how all American animals were more shit than animals

from everywhere else in the world. And it was during the War of Independence and so it was really popular to hate on American stuff, right? And so he couldn't have pissed off Thomas Jefferson more if he tried. He didn't know anything about Thomas Jefferson. He was busy fighting with Linnaeus and Linnaeus was busy classifying things and this guy was like there's no more than 200 species of animals anywhere. So why would you bother with that sort of academic silliness rather than think about like how the animals got this way in the first place.

In his mind, discovering why American animals were so shit was the right way to be spending your time as a natural historian. But this pissed Teddy Roosevelt off, and so he was trying to figure out how he could prove to this guy that American animals were actually better, bigger. So he was getting his friends to compile lists of things about how American bears are bigger than European bears, American wolves are bigger than European wolves, that it isn't that you come to America, like this guy said,

and you suddenly get weaker and your blood gets watery. That was what he was really... That's what they thought. Yeah, that's what he... And it was a best seller, apparently. That's incredible. So they thought living under oppression was really good for you?

It's like strength training. They were probably imagining, I guess when people came over, they did, there were new diseases they probably did get sick. And so there was probably something in it. But so Jefferson went so far as he had, he had a moose sent to this guy's house on his doorstep, but it was like partly rotten when he'd gotten there and somebody put the wrong antlers on its head. It was just like really dumb. But his main feature was mammoths that he knew that this animal, he didn't think they were extinct at the

time. And nobody really knew about the idea of extinction. He was convinced that Lewis and Clark were going to find them, that people were going to find these mammoths still there. And that was going to prove. Isn't that incredible when you just think that just a few hundred years ago, that was the pinnacle of science. That was like the peak of understanding of all the species that were still alive. We really didn't know. What I don't understand about this is how a person who is a scientist can look at how

everything has changed in a couple hundred years or in 20 years when it comes to genetics and still say, oh, we know everything. Like, I'm right. Like, I think it's what you were saying earlier. It's a famine mentality. It's just weak people's minds. And there's weak human beings out there. The way they think is a very weak

way of thinking. And they want all the attention for themselves, and they're very egotistical. And it's also very supported by academia. There's a lot of bitching and fighting in academia. It's really gross. Late 18th century, the idea of extinction was only just beginning to be popularized by some thinkers. George Cuvier. Cuvier. Yeah. Jefferson wasn't among the believers. In a pre-Darwinian age,

extinction was a violation of religious ideals. God would not let animals go extinct. And secular ideas, the balance of nature could never be so significantly upset. So for Jefferson in particular, extinction was just an unusual theory. It's fine, the bones exist, he wrote. Therefore, the animal has existed. The movements of nature are in a never-ending circle Well, that would that's the real question like there have been animals that went extinct and then came back right the dire wolf Right, but that was because of you guys wasn't there like a bird that that thought was extinct That's not and they didn't go extinct right, like sort of like the Tasmanian tiger. They just became, or Bigfoot.

Oh no, the Tasmanian tiger was definitely real. But some, maybe with thylacine. But Bigfoot was real, it was Gigantopithecus. They think that that was real. But Gigantopithecus is really old. Right. But, and would have changed until today. I mean, I told you, I have tested,

people send me all kind of crazy things. The insulation was one of my favorites. This is something that I got while I was you, I have tested. People send me all kinds of crazy things. The insulation was one of my favorites. This is something that I got while I was still doing my PhD. People would send us all sorts of crazy things. Isn't your insulation, they said it's Bigfoot fur? Yeah, it was from a guy somewhere. No, no, no, no, no.

They didn't say it was fur. No, it was better than that. It was, yeah. He was from somewhere in the Carolinas. I can't remember where. And he'd sent a letter, and it was a handwritten letter on his personal stationery which had a naked girl dancing around a pole, which gave him obviously more credibility. That's his stationery.

He's emailing you from his trip club. It was a written letter. Letter from his trip club. Sorry, everything's an email to me now. It's a while ago. And he sent a couple of cuttings of insulation from his basement, telling me that the family of Bigfoots that lived in his basement, he had seen urinating on this insulation. And so if I was going to get Bigfoot DNA, it was going to be from that insulation.

Oh boy. Did you test it? Of course I did. You really did? I would have tested him for meth. I said, I'll test something. Let me find out what you're doing, dude. You're Bigfoot bees in your basement. I said, I'll tell you something. Let me find out what you're doing, dude.

You're bigfoot peas in your basement. I didn't get any gigantopithecus DNA. There was some human DNA on it. So what was the year that gigantopithecus, we believe, went extinct? So the bones were found in an apothecary shop in China in the early 20th century, right? I don't actually know.

I think gigantopithecus is millions of years know. I think the Anapipithecus is millions of years old. I think the story is that an anthropologist was in an apothecary shop in China and found the bones, I think this was in the early 20th century, and I think he said, where did you get this? He's got giant primate teeth, and they took them to the place and they found jaw bones that indicated it was bipedal and then they started like digging and discovering. I don't think they have a full skeleton. Oh, that's so cool. Right?

Well, most things from paleoanthropology are, you know, I'm going to rewrite human history because I found a partial jaw bone with three worn teeth. Here's the problem, right? You could tell me whether this is correct. Most things will never be fossils. Right. Right. So we don't even know how many species existed and never left a fossil.

Because fossils are hard to make. Right. So we're essentially getting the tiniest little bits of information. And we're trying to piece together this understanding of millions and millions and millions of years of creatures on this Earth. And to do so arrogantly seems so crazy.

To be arrogant about something that has just by the nature of its existence, how do you find it? It's a very limited resource. Right. This is one of the super fun things about ancient DNA, right? So I think, I don't know, remember who it was who said this, but we don't have any idea if your bone, you paleoanthropologist, if your bone has descendants, but I know that my DNA has ancestors. So I can learn a ton by sequencing the DNA from the people that

are around. And if I am lucky enough to get it from these bones that I know is real about human history. And paleoanthropologists and archaeologists in the beginning of ancient DNA hated it because it was going in and going, oh no, turns out you were wrong about that. Yeah. Oh, Neanderthals and humans didn't interbreed. Oh, turns out you were wrong about that. Oh, they were only-

Yeah, I remember them teaching us that in high school. Yeah. Based on what data, though? I know, but that's the thing is they taught it so arrogantly. Did people breed with Neanderthal? Nope, that was impossible. They would say it so arrogantly. This is just high school teachers.

And now we know that they did. And we've been able to learn so many cool things about humans from studying this Neanderthal genome. I mean, I know people get hung up on DNA and how you need lots of DNA to define a species, but we have been able now to look. I think one of the coolest things that we've learned from the Neanderthal genome is that we all know that we have somewhere between 2 and 5% Neanderthal DNA in our genomes. We kind of get that now. You can get your DNA

tested at one of these DNA testing places and they'll even tell you how much Neanderthal DNA in our genomes. We kind of get that now. You can get your DNA tested at one of these DNA testing places and they'll even tell you how much Neanderthal you are so you can have a competition with your brother and your cousins, right? I'm more Neanderthal than you. I'm amazing. Happy St. Michael Day. Less well-known, though, is that we all have a different 2 to 5% Neanderthal DNA. And if you were to go around the world and collect all of the Neanderthal DNA and if you were to go around the world and collect all of the Neanderthal DNA sequences that are in people alive today

We could put together like 93% of the Neanderthal genome That's cool, right? So it's crazy two questions Then are they actually extinct if we can put together 93% of their genome by pulling together people who are alive today? That's just a fun philosophical question. Second is, what the hell is going on in that other 7%, right? And if we want to know what it is that makes us human, that's where we look, right? That's where we ask, what are the mutations that arose since we split from Neanderthals that if a baby got that part of the Neanderthal DNA,

it didn't survive. It couldn't make it as a human. That is the bit that is important to define us. We've actually been able to narrow that down. There's less than 100 genes, we think, less than 100 mutations in genes now that have evolved since that split that most people that are alive today have. And that is what makes us human. I think I'm still fixated on what you said earlier because I think it's so important that we decided what these animals were. We gave them these very specific names and that genes and nature don't they don't care what we're saying. There's this weird thing that's happening from the time we were proto-homidids to what we are today.

It makes sense though. We want to have a conversation. And if we want to talk about something, we have to call it something. Right. Australopithecus. Right. So we have species concepts that we designed that allow us to have a conversation and know what we're talking about. So when I talk about, and I call this fossil a name, you and I know that we're having the same conversation.

If I am in charge of delineating species because I'm trying to figure out which agency is going to care for this endangered species, I might use geography to figure out what one species is and what another species is. The species concept that we learn when we take our introductory biology course is a species concept that was developed in the middle part of the 20th century called the biological species concept, which says you're a species if you can breed and if your offspring are fertile. But we know that lots of things violate that. Brown bears and polar bears, we just talked about how they're hybrids. Humans and Neanderthals violate that.

Cattle and bison violate that to a way less of an extent than we thought that they did. This is actually a cool story that I think that I think. Do you know what a beefalo is? Yes. Yeah. Is it the female cow and the male bison or vice versa? No, a beefalo is a breed of hybrid that is 5 eighths cattle and 3 eighths bison that supposedly has better meat.

Oh, do they do it on purpose? Yes, it was one of these breeds that they tried to make. But does it work both ways? Does it work with a male bison and a female cow or a male bull and a female bison? Turns out it barely works at all. Do they do it artificially or do they have them party together? No, they just lied. Oh, it's fake?

It's not real. Oh my goodness. So I've always, I've spent a lot of time being interested in this admixture history. And so I was interested in brown bears and polar bears and humans and Neanderthals. And what is it that suddenly makes a species not able to breed with another species? What is it that causes that sort of last wall to go up and then suddenly you're the biological species? Yeah. What exactly is it? Can we figure it out? And so I wanted to look at these different species pairs.

And we knew about beefalo because people have beefalo ranches that you there's a beefalo of the week. You should look that up because this is going to be like there's beefalo of the week competition where you see these animals. Anyway, so people in the early 20th century decided that they wanted to make hybrid cattle and bison because they wanted animals that were as robust in the North American prairies as bison but as tame and easy to deal with as cattle. They started breeding them together. And we're just like, this isn't working.

This is really hard. When we get the F1s, that's first generation hybrids. Often it's only the females and they're not reproductive. There's problems here. We can't do this. So then people kept trying to do it because they really wanted to do this. And then there was this guy called, I can't remember the name of the person who actually did it, who claimed that he had been able to create this animal that was 3 eighths bison and 5 eighths cattle. And he sold his animal to a guy called Bud Basolo in California, who created this herd

of 5,000 beefalo. And it was announced with great fanfare, like front pages of newspapers. He sold one animal to a farmer in Canada for $2.5 million, $19.75. It's still the most expensive single animal that has ever been sold, right? $2.5 million, $19.75 for this animal. And so we have this thing, I was like, we're gonna sample them. We were working with collaborators from the USDA.

We were reaching out to people, reaching out to ranches and saying, can we have a piece of your stuff? And they were like, not sure about research on this. And so we started buying tongues. Because if you buy steak, you just get the same animal over and over again, but they all have one tongue. So you can just buy tongues and then you get lots of different animals. We sequenced their genomes.

And then we got from the USDA their expired sperm straws that they have for the animals that they give away to start your beefloat thing. We sequenced their genomes as well, including this $2.5 million 1975 individual. And we've done a lot of work on bison and cattle throughout the last 30 years of my life. And so we have this big plot that shows bison on one side and cattle on the other. And we had made a hybrid so we could sequence their genomes.

He wasn't born. He was an aborted animal because, you know, it's very hard to make a hybrid. He fell right in between them in the middle where you expect him to be. So now we know exactly where we think our beefalo should be. You know, they're 5 eighths cattle, 3 eighths bison. They should fall out closer to cattle but still up here. And so you plot them and they're all just cattle. 100%.

They're just cattle. It was fake. So did they use like Highland cattle or something like that? That have those crazy furs? There's some evidence that they used Zeeboo. So it's a, that's a different type of cattle. It's the one that came from Asia. They have them in Brazil because they have a hump. So it makes it look a little bit more like bison. But if you look at it, if you look at the pictures of the beefalo of the week,

you look at them and you're like, yeah, those are cattle. Let me see the beefalo, Jamie. When I did the beefalo of the week, I went down a weird path. So I just kind of came back. Oh, boy. Wrong websites. No, it didn't seem like I was on the same path. When was this all discovered that these are just cattle?

Oh, just look up beefalo. And to look at historic beefalo, you can see the pictures of historical beefalo Yeah, when was it discovered that these are just cattle? Um, we just published the paper like a few months ago Oh, no, so this poor dude from 1975 that spent two million bucks Yeah, and he sold it back to the solo for some of the money getting back I mean, I think there was a thing going on there So these people are out here still selling beefalo like it's real like this is a website. And their hybrid was something they're mixed with

a little bit of zee boo some of them have a little bit of bison in them but this is a... They're just cows. Yeah. Interesting. I talked to Steve Vernello about this I know that he's a friend of his. He was like, that's hilarious. It is hilarious. It's very funny. It does look different than a regular cow though. A little bit. I mean they were trying to do that, right? And we can engineer everything. But that's not what they did. I mean a chihuahua looks different from a Great Dane, but their DNA is a lot the same. So in 1975, how much of an understanding of this stuff did we have? Did these people think that they were doing this or was it just a scam?

I think it... well, this is me speculating at this point. I think he had to know, right? And there was, at one point, there was a test, a blood test that they had done where they were looking for markers in the blood and there were five different markers and they tested about 150 different animals and they published a paper saying, oh look, we tested all these animals. None of them have all of the markers. One of them has one of the markers and we just think the test is bad.

Oh. No, just. Boy. Yeah, fun. Anyway, I digress. I don't remember what we were talking about. Well, we were just talking about a bunch of different animals that used to exist. You know, we were talking about Gigantopithecus at one point in time. You said it's really old. Was it 100,000 years ago?

I think it's older. Older? Yeah, I don't know. Maybe. So, 2 million to approximately 3 to 200,000 years ago. Okay. So, as recently as 200,000 years ago. So you like kind of, homo sapiens are like 300, 400,000

years? Diverge from Neanderthals. Is that like around that time? Yeah. So it is possible that at one point, and so this is just a very limited amount of bones, right? It's just limited, just like everything else in paleoanthropology. So it's possible that they existed later than that.

We just haven't found those samples yet. Maybe. But it's just speculation. There was a really cool, this is just about how we don't know anything. We can actually get DNA directly from sediments. And this has been a relatively recent revelation. It's super cool because it means that you can take a plug of dirt from the inside of a lake and you can reconstruct the whole ecosystem as it changes over time. Super cool, right?

Wow. But recently, there was a paper that was published by some colleagues of mine that had done this Reconstruct the whole ecosystem as it changes over time super cool, right? Wow But recently there was a paper that was published by some colleagues of mine that had done this for sites in Canada And they found mammoth DNA and horse DNA in Canada in these really well-preserved parts of the world where we've been working That date to probably around four thousand five thousand years ago Horse DNA. Yes in That's weird right? Because they're supposed to be extinct in North America when? Ten thousand? Around the last, but you know there are a lot of Native American cultures who believe that they have a long history of the horse and that the horse has survived and it's just dismissed because we don't have evidence for it. But until we

find DNA directly in dirt, I mean this is just showing us how much we don't know. How much we have to be really willing to... You know, obviously, we have a model of the way the world works. And we don't just throw away the model with new data, but we have to incorporate the new data and see how it impacts. Right. You can't be arrogant about the model. So the model is, if you correct me if I'm wrong, that horses evolved in North America, but it went to other continents, but then eventually died off in North America. But survived elsewhere. Yeah, Eohippus, the very first horses are from 50 million years ago.

They're found in Wyoming, in the fossil deposits in Wyoming. Those are the little house cat sized horses. House cat sized horses. Yeah, but you know, this is early horses around the same time as we have the first primates and the first of the other things that we know. That's so fascinating. It's so cool. It's so fascinating. Yeah. Well, we were talking about this the other day, the big debate that happened with Clovis

first that they used to think that human beings, they came over here at a very specific time and then they found those footprints in White Sands, New Mexico and they're like, okay, we've got to rethink this and we're being forced to rethink this. And there was another time where archaeologists were horrible to each other. These scientists were horrible to each other because they attacked the guy who made the discovery. They said, this is nonsense. This is impossible. We know. We're very clear, which is this arrogance. Yeah, they did that to Jacques Sanck-Mars, who discovered the bones in Alaska, Northern Canada that had cut marks on them that were

older than the accepted time of when humans could be there. And now everybody accepts that as it's true. We know that. Yeah. It's so gross. It's so gross and they keep doing it over and over and over again. So then the question is, okay, if we have 22,000 year old footprints, how many thousands of years were they here before that?

Have they always been here? How'd they get here? Like, what's the earliest known humans, you know? We know that there's no Neanderthals here so far. So far, right? So far, there's no Denisovans, but imagine they found a different kind of human. Wasn't there something that came up

where they found some human that lived, God, I wanna say 6,000 years ago ago and his DNA is different. This is like very recent. Different than anybody that they've ever discovered before. So, okay. Well, that would be interesting. I think this is like super recent, like yesterday or the day before. But it's just these things keep, they keep finding new stuff. Here it is, 6,000 year old skeletons with never before seen DNA rewrites human history. Yeah, so this was just June 7th. Yeah, I don't know anything about this. Yeah, they uncovered six thousand year old skeletons in

Colombia that belonged to a mysterious group of people that could rewrite human history. It doesn't match any of the other known indigenous populations. No, wild. Their genetic signature reveals a distinct, now extinct, lineage that may have descended from the earliest humans to reach South America, one that diverged early and remained genetically isolated for thousands of years. Yeah. This is, I mean, I have no doubt that this is true. I mean, how many of these human settlements are gone now, and so we don't have any evidence

of them. And they're all lineages that they all go back to humans originating in Africa at some point but we haven't seen all of them we haven't seen all of the pattern we don't know even what questions we should be asking you know what you guys really need to try to bring back those little tridactyl skeletons they find in Peru you that's like when we had Luke Caverns on and Jesse, when we had Jessie Michaels on the other day, who has an amazing YouTube show, both of them great guys, they were showing us these skeletons that they found in Peru that are very bizarre.

And people initially thought they were hoax, but then they found these newer ones that they've discovered that they have three fingers and three toes and done CAT scans on these things and they seem to be human or human like these things Yeah, I've seen of these they're amazing like I thought 100% horseshit when I first saw them because I think some of them are horseshit Yeah, but then when they've done like look at that image below where they do like x-rays of them like come on like what the hell is that? Like what is that that seemed that there's no way if again, I'll say it again, but if that's art Let me buy it. Yeah, like if you've somebody made that so those those x-rays are from the the the things themselves I think I've seen some of these cats cans are even weirder

Are they because the cat scans when they show like these the 3d? Cat scan of the body you're seeing all the the areas where the cartilage is and it just but it doesn't look totally human because this is it so they have three fingers and three toes it's really weird stuff like there's layers of them as they go you know as you go through a cat scan now how old are they I've seen some of the reports this is the thing that was presented to the Mexican government at some point This is Peru the Mexican one seemed to be horseshit. Okay, it seems like and the guy who discovered them air quotes

right seems to have a history of Finding silly things, but this seems real. This seems very real like look at this thing What's that on the neck exactly? What is that on the neck? Who the hell knows like who the hell knows? Why does it have so many ribs like look at it go go back to that image where it shows the back Jamie where it was like yeah like when you see this thing this guy's not like showing you the full body in this particular image whatever the hell that thing is on the back of his head is where the shape of its head is very weird but it looks real like whatever if if you guys could

find that that's real I know you won't bring back Neanderthals but why don't you bring back one of them little three-toed alien people? I don't know I mean you would still have to ask their permission it looks like a person. Listen, just talk to them. Bring them back. If they say no, shoot them in the head. Right. Easy. I don't know what to tell you but bring them back like some things you just have to do like if we find out that that thing was a real thing, like, what is that? What's that thing in the back of its head? People tried to do DNA work or protein work on these things? I think there's a small select group of people that are even taking it seriously.

But more people are taking it seriously now because of the CAT scans. Because I think initially, have you seen the original ones, the ones that look super fake? Yes. The ones that look super fake look like something you'd buy in a roadside stand. They look totally bullshit. But then I was going back and forth with Jesse Michaels and Luke Caverns and they were sending me these images of, I think it was 800 BC. This is how old these drawings are in these tapestries that show these weird three-toed, three-fingered things that look

like a little one of those things. So was this another type of human that lived with us at some point in time? It's interesting. There are the three toad and three fingers thing is interesting. I wonder if there's a genetic mutation that would lead to that. You've seen that the tribe, there's an isolated tribe that has the two. Yes, ostrich feet they call them. Yeah, very weird.

Yeah. So, maybe that was that. Maybe that's what that was. I mean, who knows? It'd be fascinating to see if there's any DNA that could be recovered or proteins. Yeah Yeah, so once you guys get down to Peru Yeah, I'll run it by Ben see what he thinks. He would be in Ben seems like he'd be like, let's go like if you could find Gigantopithecus DNA, I think Ben would want to bring back Bigfoot. Yes, probably let's not tell him

I think that's what Bigfoot is don't you think? Gigantopithecus. Yeah, was it in Asia that's what Bigfoot is, don't you think? Gigantopithecus? Yeah. Was it in Asia though? Like Bigfoot is supposed to be in North America. Well, they found the bones in China. Yeah. So it could have come across. See, make sure that story is right that I said.

I'm pretty sure that's true. Gigantopithecus bones found in the apothecary shop in China. I just didn't want to bring it up. That's a guy named Ralph von Konigswald, 1935. They're being sold as dragon bones. So they bought a bunch of stuff and then they started looking at them and found out that that's not what they were. So it's 35. That looks very old, right? Early to middle Pleistocene in China. That was super interesting.

And I wonder, you know, if these populations were there, they're there at the same time as Denisovans were there and Neanderthals were there. If they could have hybridized with humans, they probably would. Who knows? We know so little, right? Well, it seems to like... It coexisted with Homo sapiens. So I mean, but when did it start existing?

How long was it? I mean, we know that Neanderthals were around for what, 300,000 years or so? Which is kind of crazy when you think that people, you know, we've really only been running things for a small period of time. I don't know who added this. Closely allied with orangutans. Once thought to be a homonym, now thought to be closely allied with orangutans. So once thought to be a member of the human line.

Well, it was thought for a long time that orangutans were our closest living relative as well. Have you ever seen them spearfishing? No. Yeah, they've learned how to spearfish. That's amazing. They don't know whether it's from observing people, that's what they assume, but there's this crazy photograph of this orangutan hanging onto his branch, and he's got a long long stick in his am and he's like leaning into the river stabbing a fish. You got to see it because it's so crazy.

Did they learn from us? We don't not necessarily know. That's so cool. Isn't that crazy? Really crazy. Like, he's figured out how to catch fish. Yeah. Really?

Oh, it says after observing locals, which totally makes sense, right? Smart. Yeah. I mean, he's seen people catch a fish and he's like, whoa How did you do that? Which is probably how people learn like some really smart ape guy was like, you know I think I can hit that bird with a rock Yeah Learning and being able to communicate is one of the ways that we got the advantage over everything else

Right because I don't have to evolve the ability to cook dinner. I can learn from my mom. Right, right, right. But that's what's so fascinating about living today is you don't have to even learn from someone who's anywhere near you. You're learning from things on your phone instantaneously, on your laptop. And you don't have to learn because there's DoorDash. Right. You can stay alive very easy. That's true too. But it's just, you know, when AI gets involved in this stuff, when we have sentient AI that you can use to try to, you know, figure out what the consequences of bringing certain species back and whether or not it will be a pro or a con, like, you know, that's where things get weird. Like,

if we decide, okay, let's bring back the woolly mammoth. Okay, what's going to be the negative impact of bringing back the woolly mammoth? Well, they're going to eat a lot. So, they're going to push out. You don't need sentient AI to do that. I mean, we have... No, you don't. But humans will make decisions based on biased evidence. We'll make decisions based on the potential for a financial windfall. We'll gaslight people into thinking things are really a good idea and it's safe for everyone.

And we'll do things if we know that we get profit. Whereas if you have AI that's going to be completely objective, and its only mission is to analyze the outcome. Yeah. Ooh, that world. You know, we're actually working with teams of people that are external to Colossal to put together the rewilding plans and that sort of thing for each of the different species. We're not planning to rewild the dire wolves, but we still have done this.

We've put together a plan of what the potential impacts would be, but we deliberately keep that outside and hire people to put this together for us. And we haven't been delivered this yet, so we'll see what it says when we get it. Like, what are they going to say to us? Yeah, not good. They're going to kill everything. They are not going to kill everything because they're not going to be very wild. What animal do you think?

Well, obviously you guys are working with the red wolves and you plan to use which are normal native animals in North America that are threatened, which most people would agree is a good idea to give them a healthy population and release them. And that's the best argument, because there's a lot of people saying, oh, this work could be used for conservation. It is being used for conservation, yes. That's so infuriating about some of these haters.

They don't even bother looking it up, or they don't care because they just want attention, and they just want to be negative, and that's the best way to get they want to click right Yes, and the best way to get that click is to whine. Yeah to whine and complain. It's annoying. Yeah, it's gross But they have to be themselves. That's their punishment. You know, that's the life you've chose You just want to be this bitchy person. You're gonna say that one thing forever Congratulations get a lot of attention for just being super negative all the time. But the if you had to like look at their argument, like the so the argument

of like not doing this and that you're not really creating a dire wolf. And this is just you're just taking dire wolf genes and adding them to gray wolves. Have you ever have conversations with these people where they want to tell you that what you're doing is wrong? And what is your response to these people? I think that this idea that the technology that we are developing is something that we shouldn't be developing because it's wrong. It's somehow playing God.

Yes. I mean, people have been playing God for as long as we've existed as a lineage. First by making species become extinct as we spread around the world. Not intentionally initially, but we changed the habitat. We hunt things. Then we figured out that we didn't have to make a species go extinct in order to feed our families. And so we evolved domestication. We figured out how to only take the males or leave the juveniles or some way of maintaining that population so that you knew you could go back to the hunt the next year and they would be there again. And we domesticated things.

And then we transformed to really authority over everything. When we protect a species, people who think about conservation often think of this as super hands off, like, I'm not doing anything. Everything just gets to evolve the way that it should be. That's bullshit. Like, we decide how many animals live, where they get to live, what they get to eat, how many they get to eat. We cull them when we want to.

We protect them if we want to. We don't if we want to. We are as gods, as Stewart Brand wrote in the Whole Earth Catalog, right? And we just better get good at it. These technologies are not exactly the same as the technologies that our ancestors had because we are directly changing DNA sequences, but they are technologies that we can deploy to hopefully try to fix some of the things that we have fucked up already. And I think the biggest challenge that I have is to show people that deciding not to allow

ourselves the space that we need to figure out what we can do with these technologies, we're still operating within regulatory frameworks. We're still operating within the bounds of biological reality. There's a long way to go here. But if we decide that that's too scary, that we don't trust ourselves, that we're always going to make the worst decision, first of all, it's that attitude of negativity, right? It's the, I don't want to do it because it's too scary because I'm going to be bad. Second of all, it's a decision. And to think that that decision has no consequences is naive. We know what the consequences are.

The rate of extinction today is thousands to tens of thousands times higher than it is across the history of the fossil record. And a lot of that is because of us. But we have the capacity to slow that rate. We have the capacity to help species that are alive today adapt to the rapid changes in their habitat. What if we could make Hawaiian honey creepers resistant to avian malaria, which we introduced by introducing mosquitoes into their habitat and save them from becoming extinct? Or figure out how to transfer resistance to bleaching to corals

around the world? Or anything that we could do to save some of these habitats that we know are in trouble because of this combination of people expanding and natural change to the ecosystem that we just don't like. We don't want to see spruce forests disappearing because it's getting drier and that means that they can't make enough resin to fight off the beetles. We have the capacity to use these tools or at least to think about how we might develop and deploy these tools, to have a future that is both filled with people and biodiverse. I think what people are concerned with is the crude application of these techniques

and this science when it's in its infancy. And if you just take that and draw it out to its natural conclusion with improvements over time and innovation over time, it could be something that's sort of an enormous benefit to not just animal species, but humans. Right. To everyone. It's kind of like a test run.

Like, we can make a dire wolf, can we make a superperson? Like, you know what I mean? Like, it's probably the future. I mean, having regular children, like just rolling the dice on seeing what your kid turns out will probably be super novel like a hundred years from now. Yeah, it's an interesting thing to think about, right? And I think we're getting gradually more accustomed to using these technologies to cure genetic diseases like the baby that was in the news over the last couple of weeks, baby KJ, this boy who was born with a metabolic disease. He couldn't, he had a genetic change, just a single mutation that meant that he couldn't

digest protein. And people came together and mounted this incredible, like, collaborative effort to find a cure using the tools of genome engineering for this child. And he went home from the hospital last week with CRISPR editing, having gone into his own body to cure this particular disease. Wild. It's amazing. Wild.

And it was such a... It was a rush, you know, and it's a, but it's a, it's a really great example of personalized medicine that right now, obviously this is slow, but we start somewhere. And we always have to start somewhere. Like, yes, it took six months and it's one baby and it took a lot of people to do this, but this is the beginning of how we can use these tools to cure your cancer, to figure out how we can engineer a fix for a baby who's born with cystic fibrosis.

Or if you get blood cancer, can we edit the blood cells to make sure that that cancer mutation just go away? This is the beginning of these tools. For de-extinction and conservation, this is also just the beginning. We've figured out how to learn DNA sequences from the past and actually transform that into an animal that's bigger than a gray wolf and it's more muscular than a gray wolf. We've made dire wolves using dire wolf DNA and these amazing tools that we will have the potential to use to stop other species from becoming extinct. I love

it. Obviously there are risks associated with using technologies that we don't fully understand, but we're not taking those risks. We're very carefully evaluating every single one of the edits that we make. We are, in every case, interested in making the fewest number of changes possible to still bring those animals back.

What other animals are you gonna bring back? Well, what's the plan? What's the plan Beth? Well we have announced obviously the mammoth and the thylacine that's the Tasmanian tiger and the dodo which is my favorite. Oh that's cool. But we have DNA from lots of different animals, so you know, you never know. So, but is there like a, so you've announced the woolly mammoth. That's right. And where will that be? Where are we going to put mammoths? Yeah, are you going to reintroduce them area, into areas?

Eventually, that is the goal, to have animals that live in wild habitats, but this will be a very long process. Dire wolves. No, we won't be reintroducing dire wolves. Okay so not predators but you would consider... Well not dire wolves. Oh so you weren't joking about the cheetah? Well I mean we don't currently have any plans to bring cheetahs or saber-toothed cats back to life. But you might. I don't like how you said that. or saber-toothed cats back to life. But you might. I don't like how you said that. But if you did that, that would be where it would get sketchy.

If you reintroduced an animal that can run 60 miles an hour to the plains, those poor antelopes who have been living it up, because they evolved. You know that pronghorn antelopes, the reason why they're so fast, they evolved to get away from these cheetahs that don't exist anymore. That's true. But we know also from looking at the cheetahs that we have that they didn't only eat pronghorns, they were eating lots of things in their habitat.

We found- It's because pronghorns are fast. They had to eat something else, otherwise they would die, right? They had to eat some slow stuff because the pronghorns are like, let's get out of here. I mean, for every species, there will be different work that has to be done to figure out whether and where is a good idea to reintroduce them. And for each of the species that we're working with, we have councils that we've put together in the part of the world where we would bring them back together to have conversations about

where they should go, whether they should go, how many there should be, and who is willing to be the long-term stewards for these animals. Now, I know that they've talked about releasing woolly mammoths if they ever do make them in Siberia, right? Well right now we're not focusing on Russia because issues. Obviously. Right. So probably it would be somewhere in North America. Maybe that's why Trump wants Greenland. For mammoths. Is it greenland filled with ice? I mean, mammoths really need a lot of lush. The vegetation. Yeah, yeah.

So I think maybe not. That's right. But, you know, there's plenty of space in Alaska, right? Or Northern Canada or even around the plains. I mean, mammoths lived through warm periods and cold periods. Obviously, they're cold adapted because they're big and furry. Alaska would be the move, right? Because it's like the size of one-third of the United States

and they lived there. Right. And, you know. Right. And I'm not worried about the mammoth population getting out of control. I mean, these are animals that take 10 to 14 years to reach reproductive maturity. They have a two-year pregnancy. It's not like there's suddenly gonna be a thousand mammoths. This will be a very slow and deliberate and careful process. And like with the dire wolves, there will be a stage in between the first calf being

born and understanding how they're able to thrive in whatever habitat they're in. And these are really important parts of the de-extinction process. I was blown away when I heard that mammoths lived up till about 4,000 years ago on an island. Yes, a Wrangell Island off the coast of Siberia, but now maybe even maybe even in mainland North America based on that environmental DNA data. Isn't that crazy? That's crazy. Yeah. That's crazy. Well, the horses were 4,000 years, right? Horses and mammoths. And mammoths, that was 4,000 years old too? Yeah. Wow. Right, because we 4,000 years old too? Yeah. Wow.

Right, because we're not going to find the last fossils of something. Of course, because fossils are so difficult to make. Most of the things don't leave fossils when they die. That's right. What percentage of the entire fossil record, bad pun, bad word to use there, but record of animals have been fossilized. It's really hard to know, right? And because the taphonomy, which means like how things are going to preserve, differs

so much depending on where you are in the world. When things die in Alaska and you have this glacial silt that preserves things really quickly, we're probably finding a lot of things, right? But we've never found woolly rhinos in North America. So the hypothesis is they never made it across the bearings. There was a, you know, when the sea level was lower, the bearing straight was not a sea level. And instead it was, they call Beringia, it was a land bridge. Animals walked across that land bridge, including people walked across the land bridge to come into, into North America. Which brings me to the short face bear.

Oh, I don't like how you giggled. Are you guys gonna try to bring that thing back? I don't know. We do have its DNA. I love the short-faced bear. You know what I like the most about it is because I think it's so dumb that it's called the short-faced bear. Like why? Who was giving it that common name? Then they're like oh here's a bear that if it stands up it's 12 feet tall. I'm gonna call it the short-faced bear. Right. It's such an innocuous name for such a terrifying animal. Right.

Yeah. One of my favorite photos on the internet is a photo of the short-faced bear standing up next to these scientists that are standing there. And you realize the size of it, you're like, that one. Yeah. Like, what in the hell? Have you seen the long-horned bison, this bison that lived 120, 150,000 years ago?

I think I have. This is, there's a great photo that's somewhere on the internet of one of a skull on the ground and a scientist laying, that one. Yeah, there it is. Yeah, that's crazy. We have DNA from him. You might bring that back? Yeah, wouldn't that be cool?

What about the Irish elk? Yep, we could do that one. We have DNA from that. When did that thing go extinct? I think that's also the end of the Ice Age. It wasn't in North America. Right. Yeah, super cool.

That thing's nuts. It's like a moose slash elk. I love it. There were also camels in North America. There's a camel called camelops. That was pretty cool. Yeah. And a giant beaver, like a five foot tall beaver, which... Oh, that's right. I forgot about the giant beaver. Beavers scare me.

Especially a five foot beaver. A five foot beaver? Think about what a little beaver could do with its teeth. People have found logs that have been chewed on by this thing. Like, just, yeah. Just imagine. Did that die out in the ice age as well? Yes. So that's like 65% of all the megafauna in North America, right? So many big things So we lost so many big Thomas Jefferson thought he had discovered a giant lion, but it was a sloth Yeah, giant sloth. They were just the bones. It's named after him. Megalonyx Jeffersoni. Wow Well, when you look at its face

It kind of looks like it could be a cat if you don't know that much. Like if you don't know what we know now, look at the bones, that bone right there. Make that head, like look at that thing. That was like some crazy cat. So strange. Oh, what a weird animal. Slawed. I wonder if they moved as slowly as the small ones did. I can't imagine that they could have or they would have been really easily eaten by the giant short-faced bear. Right.

Right. Maybe that's why they're not around. Or the American cheetah or the smilodon. Well, the cheetah is probably too little. You know, it gets smashed. Yeah, but if that thing was moving super slowly, you could just hack at it for a while. Well, have you ever seen sloths, even little slow moving ones swing at leopards or jaguars rather?

Yeah, there's a video of a sloth, a regular one, that is crawling on this vine and this jaguar is trying to get at it. It's swinging at it pretty fast. I was like, well, I didn't know they could swing that fast. But it moves really slow, which is like, why does nature want you to die so easily? Don't they move so slowly that stuff grows on them. Yes mold grows on them. There's a rescue place So this see look at that look how beautiful this jaguars are god. They're so beautiful Big cats. Yeah, so would you want the big cats that were here to come back? Well, I mean, I don't know

It's like the jaguars are Well, I mean, I don't know. It's like the Jaguars are reemerging in the Southwest, right, they've spotted at least a couple of them in Arizona, which I think is great. I mean, I think they're awesome, but I wouldn't want to run into one, you know what I mean? Like if you're out there camping and you see a Jaguar, you're in a lot of trouble.

That's a giant mountain lion. Yeah, and I think about mountains too when I go running you know in the woods in the Redwoods I live in Santa Cruz I go running I'm thinking oh mountain lions bring my dog right yeah well the dogs gonna get eaten I guess I think they're afraid of dogs that I've a little bit yeah it depends on the dog they eat a lot of dogs I have a 75 pound Labrador retriever he would probably want to be its friend. Yeah, that's like my dog, my golden retriever. Oh, friend, can we play? Or he would just like tuck his tail and run and just leave me there to defend myself. But you know, they found that 50% of their diet is dogs and cats. Wow.

50%. That's nuts. Yeah. That's nuts. They're just eating people's dogs and cats. Yikes. Yeah. I don't know. They're spooky. They're cool, but they're spooky. You know, I don't know how many you want around. And there are a lot of cats. Maybe it's because we don't have any of the other predators that used to be there. I mean, the California golden bear is another one that Hearst, I think Hearst collected one of the last ones of the California golden bear in Southern

California. Had him shipped up to San Francisco and he became the bear that's the inspiration for the flag. Oh, really? His name is Monarch. We actually sequenced his genome too. The last guy that got killed by a grizzly bear or brown bear, whatever it was it was in California They have a town named after him, LaBette, California It's named after the guy named after the last guy to get killed by a bear. I wonder if it's worth it to him Nope Nope, nope, it's kind of funny though that the bear is on the flag and then they killed all of them

There's none of them. Yeah. Well by the time I think it was on the flag It was already on their way out. Probably. Well people are probably wanting to bring them back too. You know, we showed recently using DNA that they're really closely related to the bears that are in Yellowstone right now. So if we really want bears in California,

you could just bring those guys over. Don't do it people. I guess the thing about it is once you have them in your area You can't manage them because then people have decided that they're precious. So once they become Problems and once they become overpopulated like Montana has a bit of an issue with that now They would like to list them with people. Yes with grizzly bears They would like people to be able to hunt them monarch. They put a smile on his face

Hi guys, only you can prevent forest fires. He looks so sweet. Monarch had a miserable life though. He was mostly in a cage. He was being fed the wrong diet for a brown bear, just mostly meat. And yeah, so right now he's on display. He's not on display actually. He is in the basement in a fridge at the Cal Academy of Sciences in San Francisco. But his post-cranial skeleton, everything except his head, is at Berkeley in the museum. We've sampled it for DNA. So his diet should have been fruit and vegetables and meat. But they were just giving him meat.

I imagine he was just really uncomfortable all the time. Oh really? Can you imagine if you just ate only meat? That's all I eat. I mostly just eat meat. I'm not uncomfortable at all. I think meat is... You need a little bit of fiber to help your digest. But I bet if you had like a plate, well actually not true, I was saying if you had a plate of meat and a plate of fruit the bear would just eat the meat

but the bear probably eat the fruit too. They just eat everything. They eat cars. When I lived in Colorado... Just like people, not us, would have been like they're involved in the world of scarcity where you eat the Stuff that's in front of you Also, they really have to get fat because they're gonna chill out and just take naps for three months I'd love the fat bear week competition. I love that It's around the time when they come out there they're eating all the salmon because they're gonna get soon they have a competition between Which is the best fat bear and you get to vote for them and then there's a fat bear

that wins. Yeah, that's good fun. I love it. To me, that's the most fascinating species of bears is the bears that live on those salmon rivers because they don't care about people at all. Like there's this crazy video of this guy that's sitting in a lawn chair

and this bear comes up beside him. And this bear, he's not in the lawn chair, right? He's beside the lawn chair, but the lawn chair is great for perspective when you see how big the bear is. This bear is huge. It's like 10, 11 feet tall, long, whatever. And it doesn't care about the person at all. It just has been eating salmon. So this is it. Look at this. And salmon are so much better. Look at this. Look at the size of that thing. Imagine, give me some volume so you hear this guy talking because it's so crazy. Bear's not interested in them. There's meat

right to his right. He just lays down. I'm gonna chill. Humans probably make a terrible snack though, right? I mean we're bony, we're, or fatty. That salmon is absolutely delicious source of protein. Also, it's just flopping around in there. It's easy to catch. And he's probably full, which is also why they're so big, right? He looks full. I like him. He looks chilled. That's the bear that I would want to run into in the field. Now, I'm talking to it. Hey, hey, hey. That's crazy. Like it's a dog. Like they're talking to it. Hey, hey, hey. That's so crazy. Like it's a dog.

Like, get out of here. You're going to give Vint some, hey man, this is my space. Don't invade it. Yeah. They just, they, all those Kodiak bears, they're, that's why they're so huge. They get so much protein. I've never been out there. Oh, I want to watch them.

I want to watch them eat salmon with a high powered rifle right next to me. And maybe in a giant bulletproof hamster wheel or something. I'm so scared of those things. Have you seen the documentary Grizzly Man? Yes. Another great Werner Herzog film. Okay. I have to look at the...

Werner's actually in that film. He's interviewing the people in that film. It's one of the best unintentional comedies. It's a really funny movie. I don't even think it's unintentional, because Warner Hurtzog's a genius. I think he made it funny on purpose, because there's some smash cuts where he's just like,

oh my God, where you're just laughing. And the guy was so nuts. And he just decided to, I think, in my eyes, I think he was like suicide by bear. I think he just decided to stay long enough where eventually they just got him. He was super depressed and wanted to be an actor, and it never made it. So he decided he was going to save the bears. And the bears like didn't even care that he was alive. Like they're not used to people

being around at all. They didn't even know what he was. And then one of them eventually decided to eat him. I can't imagine that as a good way to go. It's not a good way to go. But if you're completely obsessed with bears and you're, you know. Yeah. There's a woman who's worked in my lab for a long time. She works on mountain lions, mountain lion genetics. And she said when it's her time, she wants to go. Oh, God, lady.

Don't say that. Don't say that. The one thing better about getting killed by a cat than a bear is a cat will kill you and then eat you. A bear will just hold you down. And eat you while you're still alive. Yeah. They don't care at all.

You just have to hope that you die of shock. Right. Before and after photos of these. Wow. Femme de la Fere is before they got fat. Like that one looks wild, skinny like a dog almost. Yeah, well they look real weird when they get skinny. And they look real long legged. That's one of the things that freaks hunters out

is when they see them skinned and they're hanging, they look like humans. It's like very weird. Or Bigfoot. No no well that's probably what bigfoot is honestly when people are seeing bigfoot have you ever seen a bear walk on two legs before no they walk on two legs all the time yeah all the time they walk on two legs to present themselves as larger to scare the other males sense and sometimes they have injuries like there was a famous bear in New Jersey that was missing a paw. And so he always walked on two legs.

And it just looked like a man. Like a man walking on two legs. It was just like a Bigfoot. Like if you see him through the woods, right? If it's dusk and you're going on a hike and you're already like heightened senses, you're a little weirded out already, and you see this thing, it's a black bear that's walking on two legs through the woods, like, you would be convinced be convinced that you saw Bigfoot, don't you think? Yeah.

There was a paper that was published maybe a decade ago or so where people had done niche modeling, environmental niche modeling based on Bigfoot sightings. There he is. Look at him. Isn't that crazy? Oh my goodness, yeah. Isn't that nuts? So if you saw that walking through the woods, 100% you'd think it's Bigfoot.

Oh my God, I found it. He's real He's real if that picture was just a little bit blurrier. It would be Bigfoot, right? Yeah, a little blurrier and then a little more distance and in between trees. Yeah, I talked to a lady once we did this television Show my friend. That's amazing I know it's nuts and that's a small one We did this television show a long time ago me and my friend Duncan We went to go look for Bigfoot It was part of the show was called Joe Rogan questions everything and we went to them and I met this one lady who is so

Convincing and she told me she saw Bigfoot She's in the Pacific Northwest where we were at outside of Seattle like up in those mountains It's so dense because it's a rainforest. And it's like, the way I describe it, it's like a box of Q-tips, that's what the trees are like. You know, you get a box of Q-tips, you can't see in between those Q-tips. Super dense. Super dense.

And she said she saw something that was like 100 yards away that was moving through the trees, that she is sure was a, she goes, I saw a giant ape. And I was like, what is that, an ape? I'm like, oh my God, it's Bigfoot. And my brain was going, I think a giant ape. And I was like, what is that, an ape? Oh my god, it's Bigfoot. And my brain was going, I think it was a bear. Well, that's what this nish modeling or environmental modeling study found is they looked at all the reported

sightings of Bigfoot and then created what would be the environmental niche for a Bigfoot. And it pretty much just overlapped the niche for bears, for brown bears. Yeah, of course. I mean, it's the only thing that makes sense. But the weird thing about it is the Native Americans, because Native Americans have a name for that creature

and they have many names for it, different tribes. So it's not like an isolated thing, but they don't have a lot of mythical animals. They don't have fake animals other than Sasquatch. It is weird because if Beringa, as I always called the Bering Land Bridge. Beringia. Beringia. Beringia existed and we know that it did and we know that people during that time made their way across.

If Gigantopithecus lived alongside people, we don't know if it did, but it could have and if it did, it would be in the same area. It would be in the same area of Asia, and perhaps it would have... You'd have to come really far north, though, to get across the Bering Land Bridge, because that was really far. Right. That was all glaciated and cold. So it would have to be something that was adapted to living in warmer climates,

like where it was found, as well as being able to survive. It's not like a week of a walk across the Bering Land Bridge, right? Also, we don't find primates in cold climates like that, other than humans. Right, yeah. You have to have the ability to keep yourself warm. We're so dumb. Let's just keep walking north. We've got to get away from these other assholes.

Yeah, I really love mosquitoes. I think this is what I'm going for. More mosquitoes, the better. I think they're probably just chasing animals, right? Yeah. That's probably what they were doing. Bison, bison mostly. Yeah, following the herds.

Yeah. And then eventually they had to learn to adapt to these colder climates. Yeah, it's funny we talk about it as like people are moving deliberately through this landscape when clearly they weren't. You know, they're just trying to find food like the Dolgan people. They're going to places where there's still grass that their reindeer can graze on. Yeah, they just want to eat. And it's just so weird to think that, you know, we live in houses and we have internet and we you know, you drive an electric car to work and living in a sophisticated world. But not all the people are living in this world and there's indigenous people that are living the same way

they've lived for but that now they have a snowmobile. Now they have a rifle. Right. But they're still like if you had to live there you'd be be like, oh my god, what am I doing? Where is Starbucks? Right. But somehow they're happier than us. That's so weird. It's really weird. Out of all the animals that you guys might potentially, what's the word, rebirth? What's the word? People have used the word de-extinction, which I kind of hate because I can't figure out how to conjugate it in a way that doesn't make me cringe. Right. If you've done it successfully do you say you de-extincted something? So what would be the word?

Do we need a new word because it's never happened before? Bring back, resurrect. Resurrect. I think resurrect is probably right but that has biblical implications right? So that's why we try to stay away from but you Kind of playing God so let's go with that Okay, cool. I mean, um, is there one that gives you pause like maybe the short-faced bear pause Like maybe like maybe this isn't the best idea the hostile. Well humans I've already been positive this like a Neanderthals and Denisophans. They were people and so I feel like That's not really the thing that that's not somewhere we should go. Host eagle. That's a cool one. That's a really this was a massive Massive giant eagle that ate moa that which was a bird

People to know they think that they found the markings on human skulls there that indicate Talons of Raptors. Wow. Yeah. Wow. Right. Which makes sense that that's how they went extinct. Like the New Zealand's are like, enough of this shit. Yeah.

Well, the moa went extinct and so they couldn't eat any moa anymore. But maybe it was both, right? Why did short-faced bears go extinct? Probably because nobody wanted a bear that stood 12 feet high that was a hypercrow. What are you going to do about it though? Imagine, would you imagine the daunting task of getting a group of guys together with spears to go after a short face bear when you know at least four or five or you

were getting whacked before you can get a spear tip into one of them? Doesn't it depend? I mean, maybe what they were doing is you know how they would ambush mammoths and things like that. So you hide around bluffs and you can have a group of people in different places I mean, maybe what they were doing is, you know, they would ambush mammoths and things like that. So you hide around bluffs and you can have a group of people in different places and hit them all at once. Maybe you wait until that bear is eating something else.

Oh, sure. And then it's paused and you have time to... I mean, how much did they even understand the wind back then? Like the scent? They probably understood it really well, right? Because these are people who relied on that. They probably understand it better than people who aren't hunters today, right? So they probably knew that these animals had a greater sense of smell than we do.

They probably had a greater sense of smell than we do or more tuned. Oh, yeah, for sure. They probably could smell it because you can smell certain animals when you're like you. If you go into the elk woods, you 100 percent can smell elk. And is that something that you've been able to develop? Well, I was taught it, you know 100% can smell elk. And is that something that you've been able to develop? Well I was taught it you know I would smell something and then you know like the guys that I'd be hunting with like you smell that like that's that's elk because you could so because they urinate everywhere and you know you get this sense they have like this really musty smell during the rut

too and you could smell them. Could you smell the dire wolf? Well they were stinky. I don't think you guys are bathing them. Why would we bathe a dire wolf? I know my wife would be like take him to the groomer. She hates when my dog gets stinky. She hates when I like take him out into the dirt and play around with them and he comes back covered in burrs and stinky. Gotta brush them down. Did they smell different? Yeah, they did smell different. But I don't smell a lot of dogs that are never bathed, right? Most of the dogs that I've ever smelled.

Wolves. These aren't dogs. Yeah, right, wolves. Right, right, sorry. But which is really weird, those are the other conversations we had that they all come from wolves. Like even a French, Jamie has a French bulldog. He's adorable.

That was a wolf at one point in time. We don't know which wolf, right? I mean, this is, I think dog domestication is one of those places where both we come to terms with what we don't know and the opportunity to discover new things. You know, the very first scientific paper that said when dogs were domesticated looked at a type of DNA that's only inherited from your mom called mitochondrial DNA. Our cells have a nucleus that has the DNA in our chromosomes that make us look and act the way we do. And

then it has little cells that were once bacteria that we co-opted that make energy. And you're only inherited from your mom and there's a ton of them like there's thousands of mitochondrial genomes in every cell And only one of your nuclear genome so in ancient DNA because there's way more we started just with that It was the only thing we could recover and the first dog Mitochondrial genomes that were recovered people were like dogs were domesticated in Asia a hundred and fifty thousand years ago Which is clearly wrong right there weren't human populations 150,000 years ago, which is clearly wrong, right? There weren't human populations, societies, which is kind of what you need for dog domestication because they're attracted to the garbage or the living around where people were.

So you need communities of people that are staying in place together for some time before you can have dog domestication. Do we know for sure there weren't human populations like that 150,000 years ago? We don't, but we do know now that dogs probably aren't that old. I think what I read was 36,000. I think it changes all the time, which is because we don't know everything. And also probably because the first dogs were in warm parts of the world and so we we don't have the fossils. We don't have the DNA and the fossils just didn't preserve. I think right now what people are happiest with is that it was probably sometime after the peak of the last ice age, sometime 15 to 20,000 years ago.

And I'm not sure where because again probably in a warmer spot there's been lots of gene flow, lots of hybridization between domestic dogs and wolves that have made this a really hard problem. Like you were talking about with the black wolves. Right, exactly like that. But what's cool about this date, 15 to 20,000 years ago, is that most of these people are like, yeah, that's probably the date for dogs. Which means if dogs only form when there are human communities that are together, groups of people that are living together in the same place for a long time, that they were

around 15 to 20,000 years ago. That is not what archaeologists think, right? So these two weights of evidence are saying, you know, we still don't know. Sort of, right? But they do believe hunter-gatherers existed in small tribes 15,000 years ago. And maybe that was enough.

But if you think of domestication, and scientists like to have names. We like to have ways of classifying things. And so there was recently a couple of friends of mine have published a paper which they've redefined how you consider something domestic and they say a domestic population is something that can only survive within a human environment, within a human niche. And if you think of that as what our dogs are, right, they can only really survive and

breed as dogs within this human niche, then you need a lot of humans around and you need a sort of steady stream of the crap that humans produce to do this. That's still kind of early. Like, it's still, yeah, maybe there were hunter-gatherer populations that were more established somewhere in the South where we don't have dog bones. Right, right. That's what's weird. Stuff we don't have dog bones. Right, right. Stuff we don't know.

And then wolves, are most wolves from warmer climates? No, right? They're from colder climates. All over the place. All over the place? Well, Mexican wolves, right? There's Mexican wolves. There's Mexican wolves. But we think that the closest living relative of dogs is gray wolf. It's this gray wolf lineage. But we don't know if dogs are outside of the diversity of gray wolves, so it's an extinct

type of gray wolf that was the pretender of dogs, or if they fall within the diversity of all the lineages of gray wolves that are around. And that's just because there's been so much movement of DNA around that part of the tree. I think it's a fascinating story that as we get more information, we're going to learn more about people as well. I just love that. Well, dogs are the most fascinating to me because it's so obvious that there's manipulation involved. It's so obvious that through selective breeding and also getting these animals to get accustomed to people,

getting close to the fire, feeding them so they don't have to hunt anymore, and then they bark when intruders come. And we developed this sort of relationship where we work together. It's so interesting that we see the genes change into a poodle. We see this weirdness, or now it's a border collie. Like, what? And then the variety. Well, all then those two are probably Victorian right all of the breeds that we think of today whether it's cattle or bison They're you know within the last couple hundred years that is really fast

Selection by humans so we are manipulating The DNA of the species that we surround ourselves with and we have been for 15 to 20,000 years and probably longer. Just not in a laboratory. Just not in a laboratory but you know is our backyard a laboratory? If I say I like the way that dog looks but I like the way that that one can swim in water and I bet if I breed them together I can make one that has this double layer coat so they can go get in that frozen water but they'll still have that like cute look or something. That's interesting right because we're thinking about science as only being done in a They can go get in that frozen water, but they'll still have that cute look or something. That's interesting, right?

Because we're thinking about science as only being done in a laboratory or manipulation only being done in a laboratory. It's clearly done with food. I mean, it was done with plants forever. Selective breeding of plants, splicing two plants together. Right. I mean, when we graft plants together, I mean, that is like all of the vineyards in France, which are grafted onto American rootstocks because of the introduction of phylloxera,

this aphid that came from North America that was going to completely devastate the wine industry. Now they're all spliced onto American rootstocks that can survive this aphid. And isn't that wild? Yeah. I talked to a rancher in California and they were telling me that I think it was either the avocado trees were spliced on to the pistachio trees or vice versa. It's amazing that the plants can survive that, that they don't go like yo that's not me. Right, like we can't do that. We can't take a pig liver and shove it in your...

yeah, your body would fight it off, your immune system would fight it off. Well we're trying. Again, that's another cool thing that we can do with this gene liver and shove it in your... Yeah, your body would fight it off. Your immune system would fight it off. Well, we're trying. Again, that's another cool thing that we can do with this gene editing technology is we can turn off the genes that would cause that rejection to happen. So maybe someday we can use pig organs in the face of humans and save people from dying. Or we can just re-engineer a new version of your organs. Yeah. So that is really cool science. This thing called the organoids, where you can actually grow in a dish in a lab a version of a little brain, something that approximates

a brain or that approximates a heart or a kidney or something else. We're using this at Colossal, for example, to test hypotheses about what changes we might make to bring about, to resurrect, to de-extinct the phenotypes that we're interested in. If we grow an organoid that grows hair, can we see what that hair looks like without having to make a mammoth in order to see what that change is going to do?

But it has really amazing potential for personalized medicine. So I can take some of your cells, if you get a tumor, I can grow them in this dish, and I can challenge those cells with different drug cocktails to see what works before I put them in you. This technology is so cool and really just beginning. Well, it's amazing when you think about this technology and you think about what we had

just a few hundred years ago and then you push a few hundred years from now and you think what are the possibilities and the only way to find out is to do experiments like what you guys are doing and so that's one of the reasons why some of this pushback is so silly like would you rather no one ever do this work or would you like to be the one who does the work or is it just that you think the work should never be done like what is the thought process? Again, I think it's this negativity and it's this scarcity mindset that if they do this, then we can't do this, which is just, it's not the way we innovate.

It's not the way we make progress. But is this the nature of academia? Because it's very gate-ke, even inside of academia, right? You work for a university, and you have to get the approval of all the other people, and you have to be politically aligned with them, and everyone has to say the right things on Twitter. You know, it's like, there's a lot of like weirdness, a lot of group think that comes along with all that stuff.

And then you have to play politics in order to get funding. You know, you can't be ostracized. If you're ostracized, even if you have tenure, you know, when you see this with certain scientists that have very outside-the-box ideas, they get pushed out and they can't get funding anymore. Or if they don't agree with a certain narrative, what's being pushed with, whether it's public health or the environment or anything, they get just, they get ostracized. Even if they're actually talking about real data and science.

Yeah. I think we can agree that it's a mess, right? It's a hot mess. But there is genuine real science that comes out of the university system, of the academic system that we need. All the technology that led to MRIs, the early technology that gave us CRISPR, this gene editing platform, was developed using funding from the government in scientific labs by people who are willing to take risks

and step outside of that box. And then it's taken outside of there and it's turned into all of these cool things. I mean, there has to be a place where we get both of these things. Because there's some things that no one is ever going to build a business around until it exists. And we need this public system in order to do that. Yeah. And that's what's so scary about what's going on with politics and funding and research.

It's because it's like, as soon as you stop defunding research, you start making it more scarce and then making people... It's just going to get worse. Right. It gonna get worse. Right. It's gonna get harder and we're gonna fall behind and we are going to lose the place that we have had as innovators and by we I mean this country. We are gonna lose the place we have has had innovators in biotechnology, innovators in physics, innovators in all of these technologies because we've had such a robust system. It's a balance, you know, we clearly need both of these

things and right now it's broken. And there's It's a balance. We clearly need both of these things, and right now, it's broken. And there's a lot of weirdness that's going on with biology in general in the world right now. And one of them is, I think there was a third scientist that was arrested for trying to bring in toxic mold from China. We know that this one scientist was arrested and then I think there's been two more. So they're trying to introduce this toxic mold into our food supply. The same toxic mold?

I think, I think so. It might have been a different one, but I know it's also, it's the same kind of thing. See if you can find it, Jamie. When I heard this the first time, and I've only heard about the first one, my first thought was, you know, is this deliberate or is this super naivete on the part of the student? Coming from China, which scares the shit out of me. Because if China wanted to cripple America's food supply, there'd be a great way to compromise basically everything. There is a country that is investing in science. Oh my God. Yeah, just their drone technologies off the charts. I was

watching a documentary yesterday on the autonomous production of coal and so they have these coal mines now that are done entirely with electric trucks and everything's done with AI and humans aren't involved at all. So these trucks go, they dig, they mine, they fill the trucks, they bring the coal back, and then when they're low on batteries, they charge themselves. Oh my gosh. Yeah, and they're running 24 hours a day around the clock. We don't have anything like that.

No. We're not even close to doing that. No, and we're fighting about the amount of money that we should invest into very basic infrastructure. Exactly. It's terrifying. It is terrifying. It is terrifying. It's terrifying because we always hope that with every administration there'll be positive changes and it just never seems to be the

case. It's just like more and more of the same and more short-sightedness. Is it also this scarcity mindset? Like I can't agree with this person because they once said this thing. I mean why can't we have just a normal conversation like you and I are having right now? Well, I think it's because it's kind of engineered into our social media structure that human beings are going to fight with each other. The algorithm favors you looking and interacting with things that upset you. You know, this is just natural human nature. If you look at, like some of the people that we were talking about earlier, negative scientists, you see them online. They're tweeting negative things, like all day long.

It's probably because they don't have any funding. So they can't actually do any science. Chinese scientists was arrested while arriving in the US at Detroit airport. A second case in days involved in the alleged smuggling of biological material. But is it the same biological? No. Different stuff? What is this stuff?

This is worms. Worms? Certain worms require government permit. I had heard that there was a third one. This is the third. This is the third, so there's a second one. And this one happened. Oh, second case in days.

I will say, they were going to the same place. Oh boy Another Chinese scientists also going to the University of Michigan Boy, it's so that's also really crazy because the thing about China and their scientists that come over to America is they all have to check in with the CCP Like if you are a Chinese scientist and you're from China and you you're working America, you gotta check in. Which means like how much of this research is just getting shared with China? And it's all weird.

And we're focused on something else. We're focused on, yeah, Sid. They play a very long game and I think their game involves Raptors and T-Rexes and they're gonna release all the stuff that you won't do. I've seen that movie. I wonder, like I worry about that, like your information, the stuff that you guys are working on, if that stuff can be

compromised, if someone can get a hold of it, and then they start doing that stuff over there. The thing is the foundation for what we're doing, all of the stuff from sequencing ancient DNA to gene editing technologies to learning how do we link certain DNA sequence changes to the way something looks. This stuff is all out there anyway, right? Like CRISPR technology exists. We're not working on humans, but other companies are openly, right? It's not like there's a big scary... Well, you know the story from China where the one doctor got in trouble and wound up

going to jail because they had supposedly inoculated these babies from HIV, but in fact were making them more intelligent. I think maybe that was two separate stories, because I know the story about Jiang Ke, that's He Jiang Ke was the name of that scientist, and he went to jail for three years. He actually did some training in the US. His name is He. But he was trying to use gene editing tools to make these babies have a particular mutation that we know is protective against HIV.

It's the one that stops the HIV from entering the cells where it then kills the cells. And I think this was a story that was broken by a guy at MIT Tech Review a couple of days before it was announced, but he thought that he was going to be able to announce this to great fanfare in front of a community that was going to celebrate him for having done this. And the story broke a few days early, but he had set this up, a whole PR thing. He had YouTube videos that were ready to go to explain what he had done. He wasn't trying to do it in secret. He thought he was going to be a hero. But people were like, holy shit, dude, what the fuck? No, we're not editing human germ lines, the cells that will be passed on to the next generation. There's still a moratorium against doing that

work. The baby that was just born, for example, they didn't edit any of his cells that would get passed on to the next generation. It's only the cells in his body. So those edits will only ever live in him. There's a difference between doing that and it's the second one that we're uncomfortable with. I thought they were editing it to make the children have a potential for higher intelligence. I think that's maybe an unintended consequence of the gene that they were editing because mice did something like that and so I think they just assume they're gonna be smarter but I

don't think that they're old enough to even test that yet. Interesting. Maybe. But but if they knew that, wouldn't they do that? It didn't end up even being the right gene. Because is HIV a real issue today? It's not really. So the reason that this that he got whatever ethical permission he did in China to do this is because they were children that were born by IVF because the dad had AIDS And so what they were trying to do was create what he claimed He was trying to do was create an environment where they would never Accidentally get it. I guess if there's blood and it also makes them smarter It definitely affected their brains what they just keep saying sort of this article They knew that at the time. But I mean, they're there. They did. China's played a long game.

It definitely affected their brains, is what they just keep saying sort of in this article. Yeah, but they don't they don't know because they haven't been able to measure anything with these. I mean, they're guessing that would have affected their brains at this point. Well, when they're the leaders of the world in 20 years, we'll know. We'll know for sure. We'll know. Yeah.

This is what makes us smart. It's been a thing that people have been trying to solve for a long time. We're always looking for like the one or two genes that figure out this. Very few traits are encoded by one or two genes. There are some hair traits. Whether your lobes are attached or not, that's one gene that you can change. But it is quite fascinating to think that in the future dumb people will not exist. I doubt that's true. Why? It may be relatively dumb compared to everyone else that's alive then, but maybe far more

intelligent than people that are alive today. Do you know what's interesting about the efforts that have gone on to try to figure out genes that make people smart is that they can find associations between what we're classifying as smart. And this is hard. Like when you're saying smart, do you mean somebody who can have a conversation with another person and shut up so that you're actually listening to other person?

Do you mean somebody who can solve shitload of math problems and be a physicist or whatever? And be awkward socially. Do you mean somebody who's just really fucking good looking? I mean, what do you mean when you say is this thing? And so you have to define that first. And then once it's defined, if you look for associations between genes at high frequency with people who rank high on whatever

your thing is that you're ranking them on, it's different depending on which human population you're studying. So it's, I mean, and this makes total evolutionary sense. Different things were under selection in different habitats at different times And that made different people smarter in different ways for whatever that was Yeah, I actually think this is not how we start editing ourselves because that's not how evolution works as soon as we edit everybody to be smart in that particular way and to be as we edit everybody to be smart in that particular way and to be 5'10", blonde with blue eyes and perfect and never gonna have diabetes, the most attractive thing out there is gonna

be the opposite of that. So there will be, I just don't think, people are always thinking about we're gonna get super humans but they have a specific picture in their mind of what that means. That's not the same picture that the Chinese government has in mind. It's not the same picture that I have in mind, right? And that's why I don't fear it as much, I think, because that's not how it's going to happen. How it will happen is there will be some massive pandemic and we discover that there is a particular mutation that means you're going to die. and then suddenly this most unethical thing that is like

completely abhorrent and you absolutely can't do it will be the only ethical solution that is how we get there. Wow. In my imagination. Wow. Well I would love to have you back on when you get more information and more breakthroughs and more stuff that you're doing. I would love to come back on. I really, really enjoyed our conversation. You should come to the lab. I know you got to see...

I would love to come to the lab. I will definitely do that. I promise you. I promise. Thank you so much for being here. It was really great. Thank you. I really, really enjoyed it.

And your book, Life As We Made It, How 50,000 Years of Human Innovation Refined and Redefined Nature by Ash Shapiro. I think the rest of my Siberia story is in there, including the part at the end where How 50,000 years of human innovation refined and redefined nature. Beth Shapiro. I think the rest of my Siberia story is in there, including the part at the end where I got arrested. Did you do an audiobook? I did. I read the audiobook for that.

Yes. Yes. I love it. I'm so glad you read it. I hate when other people have to read people's work. I asked if I could read it because my first book, How to Clone a Mammoth, I didn't read. And I heard the audiobook and I write in first person and I tell stories and I try to make it funny and I was like, that's not how it should be read.

So I wrote to them and I said, can I read this book? And they said, oh, you're going to have to audition. And I was like, audition for your own book. What if I am not good enough to read my own audiobook? Well, you clearly are. Well, luckily you're a great talker. Thank you so much. Thank you really for being here., luckily, you're a great talker. Thank you so much. Thank you really for being here.

I really appreciate it. It was really fun. Thank you. Bye, everybody.