The Resilient Mind - The #1 Nitric Oxide Expert: Why You're Always Tired No Matter How Much You Sleep

Episode Date: August 26, 2026

Dr. Nathan Bryan is an internationally recognized expert in nitric oxide biochemistry and molecular medicine. Over more than two decades in academic research, he has made a number of seminal discoveries, earned dozens of issued U.S. and international patents, and developed what have become the most successful nitric oxide products on the market, responsible for over one billion dollars in global revenue and a meaningful shift in patient care. His work bridges cutting-edge molecular science with real-world therapies, translating complex biochemistry into breakthroughs that improve how people heal and age.Connect with Dr. Nathan Bryan: 📺 YouTube: @drnathansbryannitricoxide 📷 Instagram: @drnathansbryan 💼 LinkedIn: @drnathansbryanExplore tools from past guests of the podcast. Some links below are affiliate links, meaning we may earn a commission at no extra cost to you:💓 HeartMath: https://www.heartmath.com/resilient🧠 Muse: https://choosemuse.com/resilientmind🌿 Brain Ritual: https://www.brainritual.com/THERESILIENTMIND🌍 The Resilient Mind Podcast is a proud member of 1% for the Planet — building resilient minds and a resilient planet. Hosted on Acast. See acast.com/privacy for more information.

Where does this leave prevention, medicine? It would be very disruptive to the system. And anything that's disruptive to a system that would impact a global multi-trillion dollar economy. Nitric oxide. Why do you believe that is the foundation to human health? Well, because that's what the science tells us. You know, this over 200,000 papers published in the scientific and medical literature. What happens to a scientist, the healthcare professional, when their findings or what they know,

will work, challenges what is established. Welcome, Dr. Brian. I'm super excited to have you here on The Resilient Mind. Well, thanks so much for having me. Great to be with you. So let's maybe start off by talking about modern health. We have access to all this information, yet a lot of people feel confused about all this information

because it's competing. Why do you think that is? Well, I think there's a lot of misinformation out there. Like, we live in an information age, but, you know, not everything you read is correct. And there's a lot of misinformation out there by companies who are looking to sell you products that, you know, and make money off of it rather than address the root cause of your illness or your way of life. So, you know, I think it's, you know, I think what I've tried to do, and again, spending 25 years in academia and teaching and researching is take that information and try to impart knowledge so it becomes wisdom. And I think that's kind of the progress of what we do with all this information.

And especially in the basic sciences as a medicine, that's very difficult for someone who's not trained in the medical sciences to distill out. They just read something and they believe it. They take it as the gospel. I think that can be quite dangerous. And tell us a little bit about your background in science so we can frame your perspective for everyone listening. Yeah, sure. So I grew up in Texas. I'm a small town, Texas boy.

I went to the University of Texas at Austin. I got a degree in biochemistry. And then from there, I went to LSU School of Medicine. I completed a PhD in molecular and cellular physiology in about two and a half years. And then I went to Boston, Boston University Medical Center and trained at the Whitaker Cardiovascular Institute. Primarily in vascular biology and cardiology, trying to understand the role of nitric oxide and not only heart function, but vascular reactivity and the mechanism of the onset and progression of cardiovascular disease, which remains the number one killer of men and women worldwide. After Boston, I was recruited by Fred Mirad, one of the gentlemen who shared the Nobel Prize for the discovery of nitric oxide.

In 2005, I started my independent research career as a professor of molecular medicine at the University of Texas Health Science Center in Houston. I was on faculty there for probably 10 years or more. And then I went to Baylor College of Medicine. I was an adjunct professor in the Department of Molecular on Human Genetics. And then from there, I became a serial entrepreneur. I started companies. I made a lot of discoveries when I was at the University of Texas, fought a lot of patents,

and realized that none of my discoveries were going to be translated into product technology or drug therapy unless I did it, right? So I thought this fits to be, it's up to me. So I retired and resigned from academia and started these companies and now we're just pushing forward and developing safe and effective microxide product technology based on science, not based on fraudulent deceptive marketing, but strictly based on science, about what we've learned over the past 30 years of how the human body makes nitric oxide, what leads to a loss of its natural production. Then once we were able to answer those two questions, then and only then can you start developing product technology. I love that. And I would want to touch on, well, I do want to touch on nitric oxide

in a little bit, but with your extensive background and with the average person getting all this information, do you think the average person truly understands how medical guidelines are actually formed? No, they don't. And I think that's been the problem because they put too much trust in their doctors and they put too much trust in the system. And, you know, spending 15, 20 years in academia, I was part of the system of teaching and training future physicians in medical school, in graduate school. It's not the doctor's fault, right? It's how they're trained. But it's the system in which they're trained, because here's the problem. We do a really good job of teaching on the basic sciences, biochemistry, physiology, anatomy. But then once you start your second year,

you learn pharmacology, the drug therapy and the treatment of drugs. And then you go off and do your rotations, and then you learn the billing, the CPT codes. How do you charge for a service based on a diagnosis? And then physicians learn the finances of medicine. And then once you make a diagnosis, there's only a finite number of things you're allowed to do because that's the standard of care. And so the system is broken. And I think all you have to do is look at the numbers. You know, the U.S. makes it only 4% of the global population.

But we make up 76% of the prescriptions taken worldwide. 4% of the population is responsible for 76% of the profits of big pharma. And all you have to do is look at the population where the sickest people on earth. 90, more than 9 out of 10 Americans are metabolically unfit. Two out of three Americans have an unsafe elevation in blood pressure. There's an epidemic of obesity, metabolic disease, Alzheimer's. Hardy vascular disease has been the number one killer of men and women worldwide for the last hundred years. And it's not getting better.

So we can't keep doing what we've been doing and expect different results. That's what we call insanity. The system's broken. The system has to be fixed and we have to start anew. But no, to go back to answer your question, the patient or the patient or the, the common layperson doesn't understand this. They just know when they go to their doctor, their doctor gives them a diagnosis, they give them a pill to take, and they're expected to take that pill for the rest of their life. And yet, nobody's getting better in that. And the analogy I like

to use, if your car breaks down and you take it to a mechanic and your car keeps breaking down, common sense would tell you, don't go back to that mechanic. He hasn't fixed anything. That's the same thing with your doctor. If your doctor is not making you better and you having the conversation with him, how do I get off of these drugs? Fire that doctor. Go find somebody who has. has time, has the education to get to the root cause and understand why you're sick. And I like how you're talking about the system, because I think for most of us, when we think of doctors, they are highly educated, but we never think about how the education might be framed by different incentives, because any system has got incentives that shape the outcomes.

What incentives do you think are currently shaping the healthcare landscape? Well, I think this has changed over the past 30 or 40 years. You know, if you look back 30 or 40 years ago, big pharmaceutical companies would come in, you know, they would whine and dine these doctors to, you know, specifically, you know, prescribe or recommend their drug therapy and their products over competitive products. You know, they've kind of reeled that in now where you can't have this so-called conflict of interest. But I think the primary driver of the incentives now is just, it's fear. It's fear-based. If you venture outside the standard of care, you have the potential for the state boards to remove your license and not allow physicians to practice medicine anymore. So their job is actually on the line. And so if you don't, if you make a diagnosis, as I mentioned, then there's a list of things you can do that are approved for that diagnosis. But if your physician says, you know, instead of putting you on a cholesterol lowering medication, I want you to change your diet.

I want you to get exercise. And I want you to try these dietary supplements and let's replete missing nutrients and let's figure out what's toxic in your body and remove that. And so they do that, which is actually good medicine. But for some strange reason, maybe unexpected or unpredictable, they have a heart attack, and then that family decides to sue, they can go back and they can actually sue that doctor because the standard of care says I should have been on a statin or cholesterol-lowering medication, which the data on that basically shows zero protection.

But because it's the standard of care, they're now liable for venturing outside that standard of care. So we call it cover your ass medicine or C-YA, and it's all risk management. But it's never at what's best for the patient. It's fear-based and figuring, okay, is this the standard of care? Am I doing what the so-called experts in the system are telling me to do, regardless if I know if this is going to help my patient or not? And I don't know how I'm going to fully phrase this question because the thought just formulated.

So it almost seems like some form of intervention is required as opposed to something that might be like change your diet, which might not be intervention in a sense. And so if the doctor provides something that is kind of in alignment with the system, then they can cover their butts in a matter of speaking versus if they don't and provide something that might even be more beneficial. If something happens, then their career is at risk. I think that's partly true. The other thing is that you have to understand how doctors get paid. They get paid from payers or insurance companies. Insurance company will only pay for things that are approved, right?

And supplements and normal lifestyle changes aren't approved. So if you go and you spend 30 minutes with a physician and he goes, okay, I don't see anything wrong here. You're going to pay for an office visit, whatever it is. But if there's no diagnosis, no medicine, they're not being paid for that visit unless they're a cash-based practice. So it's a very intricate system that's been going on for more than 100 years of how we get this because the money is in treating, right?

The money by big pharma is in treating, treating disease, treating a person every day for the rest of their life. There's no money in cures. There's no money in disease prevention. And unfortunately, that's the system in which we operate, which, you know, you go back hundreds of years ago, you know, I think even Hippocrates himself said the future of the physician of the future will prescribe no medication. And you think about where we are today, again, 4% of the population, receiving 76% of the drugs, it's not making anybody better. But unfortunately, that's the finances, that's the economy, the economics of medicine. And so, Where does this leave prevention, medicine?

Well, look, it would be very disruptive to the system. And anything that's disruptive to a system that would impact a global, multi-trillion dollar economy is going to be met with a lot of resistance. But here's what we know. You know, in the basic sciences, we know what causes human disease. It's very clear. We don't need more research. We need the translation and the application of that research in the clinical practice.

And here's what I find that most people get sick for two reasons. and two reasons only. Number one, their body's missing something that it needs because the food we eat is depleted of most nutrients. Or number two, our body is exposed to something that it doesn't need in the form of toxins, viruses, bacteria, herbicides, pesticides, environmental toxicants, air toxin, air pollutants. And so if we can replete missing nutrients in the human body and we can remove from the human body, the toxins, then the human body heals itself. You don't get sick. Humans are regenerative by nature. Our creator made us that way for a reason. We're never deficient in a synthetic compound that inhibits a biochemical reaction, like a statin or a proton

pub inhibitor or an ARB, that's treating symptoms. It's not addressing the root cause of why you have these symptoms. Symptoms always arise from a response the body has to something in the environment. And what we're finding is that a lot of this goes back to those two things. You're toxic or you're missing a missing nutrient. And if you address those two, then there's, in that paradigm, there is no need or room for drug therapy. And that's the system that we have to put in place. So many questions are just going in my head. This will be the last one of this time because I really want to talk about nitric oxide. So in terms of talking about toxins, is when you look at how our lives have changed the food we eat, the way technology is involved, are we exposed to more toxins today

than we were probably 20 years ago? Absolutely, without a doubt. I mean, even if you go back and look, before the industrial revolution. It was a completely different time. And if you just go back to the 1940s, and this is published data, the food grown in America from 1940s until the 2010s, there's about a 75 to 80% depletion of basic micronutrients in the soil.

So the same food that's grown in America today, we're getting about 80% less nutrients. And then the other thing, now with these genetically modified organisms or seeds they're planting and spray them with glyphazate and herbicides and pesticides, not only are they nutrient depleted, but now we're ingesting these toxicants.

So the diet, in my best estimation, may be the biggest contributor to chronic disease, because it's not providing the nutrients we need, and it's exposing us to poisonous toxins. And then if you look at all the electromagnetic frequency, the 5G, these are frequencies that disrupt biochemical reactions and make people sick, and some people are sensitive to them. The air we breathe, you know, you see all the stuff going. on in the kill trails and coming down and, you know, the air we breathe is not clean, that the water is poisonous because it's fluorated, has fluoride in it, which is a known neurotoxin, lowers IQ in kids, it's an antiseptic, it kills the bacteria in and on our body.

So we're surrounded by this environment that's making us sick. And then when you start to look at certain drug therapy and things like in acids and, you know, overuse of antibiotics, antiseptic mouthwash, fluoride toothpaste, it's a perfect recipe for making people sick. And that, unfortunately, that's the world we live in. And I love that you mentioned some of those because some of those components, I hear a lot of discussion around like, okay, is this actually happening? Is this not happening? So the soil, the nutrients, all of that, people could be like, yes, yes, yes.

But when people hear about like 5G or the fluoride, there's a lot of conversation to be like, okay, is that valid? Does that apply? Does that not? And so for some of those things, when people are like unsure whether to believe that, okay, is this? already validated, or is it some conspiracy for lack of a better word? How can we bridge that understanding or get people to critically ask themselves questions so that they can come to a more accurate conclusion? Well, you have to be able to look at the data.

I mean, a lot of these so-called conspiracies that actually come true of the past. Yes. But it's data. You know, they come true because it's based on facts. It's based on data. And so when you look at the, you know, fluoride, let's take that, for example. That's been in the water supply for more than 100 years. But for me, it's about risk benefit.

What benefit is it providing and at what risk? And just last year, I believe the end of 2024, the National Toxicology Program, which is the government's organization to investigate any potential toxicant to see if it's safe for human exposure. And then so they look at dose escalation studies in different animal models. and even in human, the human data. And what the National Toxicology Program published last year, and granted, what's not known is that the government suppressed the publication of this manuscript for more than four years. They've completed this study four to five years ago.

The last administration would not allow publication of this because of what the data revealed. The data revealed that fluoride is extremely toxic. It provides zero benefit. It doesn't prevent cavities. It doesn't enhance the remineralization of teeth. So if there's no benefit, what's the risk? it's a neurotoxin. It shuts down your thyroid function. It lowers IQ in kids by as much as seven points. So why in the hell are we putting this in the drinking water and why are companies continuing to put it in the toothpaste?

And again, the other point of evidence, if you're using a Colgate or aquifresh or a crust, a fluorated toothpaste, look at the label of that. It says, only put a pea size amount on your toothbrush. And if you swallow it, call poison control. Why would you have to call poison control if you swallowed it? What people don't understand is that fluoride is a very small molecule, a molecular weight of, I think, 27. You don't have to swallow it. It's immediately absorbed across the bucal cavity, the mucosa. So every time you brush your teeth, you should follow those instructions. You should call poison control because you are being poisoned every time you do it.

And most people don't put a pea-size amount of toothpaste on their toothbrush. They fill the entire bristle. So now you're extremely toxic. You're not getting 5 milligrams of fluoride. You're getting 500 milligrams of fluoride. There's an epidemic of hypothyroidism, dysbiosis in the mouth, in the gut, and it's causing human disease. The data are clear.

This isn't a conspiracy. It's been vetted by the highest levels of science. It's reproducible, and it's published in peer-reviewed journals. I mean, that's the gold standard. And I think one of the things about our human bodies is that they are so resilient that sometimes when we're exposed to like the lack of adequate nutrients, toxins, we may not feel I'm like, well, I'm doing fine, so it's not a big deal, until something happened. Until we get that chronic illness and then, again, trying to figure out what caused it,

of course there's the, who treated without addressing all these things that have made us reached to this. So I do, like, agree with that, that sometimes you feel good, even when you're exposed to these toxins, but at some point your body is going to be like, you know, enough is enough. That's right. Now, look, I'm completely impressed with the resiliency of the human body. you know, being, studying the human body now for more than 30, 35 years. But no, our body always talks to us, but we have to listen, right?

And if we don't listen, then we continue on this path. And then, you know, unfortunately, humans are fear-based, right? We only make changes fear. And fear comes from a heart attack, a stroke. And many times the first sign and symptom of heart attack is sudden cardiac death. So a lot of people don't have the time or even the opportunity to correct it or treat it. But then and only then, once you develop diabetes or have a foot amputated or a toe amputated, then people go, oh, I've got a problem. Now, you've had this problem for 10, 20 years.

You should have dealt with. This problem didn't start the time your foot was amputated, the time you got diabetes, the time you had a heart attack and stroke. Your body's been telling you something's been wrong for the previous 10, 15, 20 years. And what are those signs? Well, we start to develop high blood pressure. We start to develop erectile dysfunction. We develop brain fog. You know, we start to lose our vision. We can't exercise. All these, our body telling us, hey, something is wrong, make some changes. But until there's a tragic event, unfortunately, people aren't willing to make those change. And one of the core things you talk about, and I think it's like kind of the core of your work, is nitric oxide.

Why do you believe that is the foundation to human health? Well, because that's what the science tells us. You know, this over 200,000 papers published in the scientific and medical literature. Nitric oxide is a signaling molecule that's produced in the lining of the blood vessels. It's produced by bacteria. but it regulates everything that we know that's required for human optimization and optimal performance. It regulates blood flow and circulation. It improves oxygen delivery. It mobilizes our stem cells. So if we have an injury or we were to repair and replace dysfunctional tissues,

it activates mitochondria, the energy producing organelles of the cell so we can, each cell in the body can do its job. It prevents the shortening of our telomeres, the ends of our chromosomes, which longer telomeres, longer live, shorter telomeres, shorter live, decreases inflammation. it reduces oxidative stress and it corrects the immune dysfunction that we see in all chronic disease. So when you start to think about what nitric oxide is and what it does, when you lose the ability to produce it, that sets the stage now for the onset and progression of chronic disease. You get decreased blood flow, decrease oxygen delivery, runaway inflammation, oxidative stress, and immune dysfunction. And those five things describe every single age-related chronic disease

from heart disease, diabetes, Alzheimer's, kidney disease, liver disease, pulmonary disease, autoimmune disease, you name it, those are the five things that always occur in those diseases. And it can be traced back to a loss of a single molecule. And because when we met prior to this interview, I confused it with nitrous oxide. Anyone who might be making that confusion, can you just clarify the differences? That's a very good point. Nitric oxide is N-O. It's one nitrogen, one oxygen. nitrous oxide is the dental anesthetic, like N2O. So it's a gap, both of them are gases.

One's delivered as an anesthetic and the other is delivered as a signaling molecule. One's naturally produced, one's not. But yeah, nitrous oxide is not nitric oxide. What we're talking about is nitric oxide. And with nitric oxide being so central to vascular function and performance, why don't we hear more about it? Look, it's a good question. I think that's why these conversations you and are having are so important.

and so we can, you know, increase awareness and education on this molecule. I think it's not well known because it's not part of a physician-patient conversation. So if you go to your doctor, you're going for a checkup or an illness, they draw blood, they do hopefully a physical exam, and nitric oxide's done something you can look at in blood because it's a gas, and once it's produced, it's gotten less than a second. And unfortunately, most physicians think that if you can't measure it, it's not important. They only treat what's measured, and nitric oxide is not measured in clinical practice so they don't treat it and it's never part of the conversation. And so I think that's mainly

a barrier. And then the other thing is, you know, there's no safe and effective nitric oxide therapies on the market for in an outpatient setting. There's inolative nitric oxide therapy for inpatients, people who are hospitalized. But even if they were to an astute physician says, look, your high blood pressure and your rectalibus function seem to point to a nitric oxide deficiency. There's not a prescription they can write to get filled to address a nitric oxide deficiency. Although I will say that the drugs like Viagra, which are phospholidestriase inhibitors, are dependent upon nitric oxide production, but those drugs do not affect or improve nitric oxide production. They improve the downstream signaling of nitric oxide. So again, doctors don't want,

they don't treat something that they don't, yeah, they don't have an effective treatment, even if they recognize this nitric oxide deficiency. They wouldn't know how to treat it. And then the other major problem is if they wanted to use dietary supplements or nutritional products, there's hundreds of them out there. But yet 99.9% of them would not improve the nitric oxide product. So then if they even recommended that, then the patient would come back and go,

hey, this product didn't work for me. Then the doctor feels like an idiot or ignorant, which ignorance is fine. It's just a lack of information and wouldn't do it again. These products don't work because they can't work. These companies selling these do not understand the science. And if you do not understand the science,

you have no business marketing or selling a nitric oxide product. And so you said, A, doctors don't know how to measure it, or they don't have the tools to be able to measure it. How is nitric oxide measured? So if I'm hearing this and I'm like, okay, am I depleted? How can I determine, like, if I've got normal levels? How would I go about doing that? There are some medical devices that are very effective at measuring vascular nitric oxide production. And this is a technique called venous occlusion, kleptosography. And what we're looking at is what's called flow-mediated dilatation or FMD. And so these are devices you typically put it on the brachial artery in the upper arm,

and then you acclude blood flow for five minutes. So you're completely shutting off blood supply to the forearm. And then after five minutes, you release that cuff and through an ultrasound probe, you can look at what's called reactive hyperremia, how well these blood vessels dilate. And the response to that dilation or that is dependent upon how well that blood vessel makes nitroxane. So we call this endothelial function, or if it doesn't dilate, endothelial dysfunction. And that's really the only true functional measurement of nitroxide.

You know, years ago, I developed a salivary test strip back in 2010 because we were trying to answer the question that you ask, how do I know if I'm nitric oxide deficient? And because I discovered when nitric oxide's produced, where does it go, what does it become and how does it signal, I developed a salivary test strip that we could detect salivary nitride as kind of a proxy for total body nitric oxide production. And we used that for a while, but then I found that there were not too many false positives Because what we were finding was people who were systemically nitric oxide deficient had all the clinical symptoms, diabetes, high blood pressure, erectile dysfunction, obese, dementia. They would use this test trip and they would light it up like a Christmas tree, turn bright peak.

And we would equate that with optimal or normal. And then what's going on here? Well, for deeper investigation, we found that these people had active oral infections. So the local immune response in the oral cavity was showing a false positive when systemically they were completely. devoid of any nitric oxide. So I just stopped using those test strips all along. I abandoned the patents on them. Now you've got probably a half a dozen companies out there selling my nitric oxide test trips or the test trips and calling them nitric oxide test strips. But believe me, they are not measuring nitric oxide. Again, these are companies who, again, if they understood

the science, they would know better. But they just don't understand the science. And some people understand the science, but are more interested in making profits off of you and defrauding you, and they continue to do it. But so really, we have to rely on. on symptoms. And so if you have erectile dysfunction, if you have high blood pressure, if you have diabetes or insulin resistance, or if you have brain fog or mild cognitive impairment, then those are clear signs and symptoms of nitric oxide deficiency. Take action. And again, it's very simple. Stop doing the things that are disrupting it and start doing the things that promote it. And what organ produces a nitric oxide or how is it produced naturally in the body?

Well, there's the largest organ, which is what we call the endothelium, the cells that line all blood vessels throughout the body. That's the primary source of nitroxide. So it's, it's a large So it's feeding every organ system in the body, right? Every organ tissue and cell has to be supplied with the neighboring blood vessel. Those blood vessels are lined with endothelial cells. So we call that endothelial analysis. It's also producing our neurons in the brain. And then our immune cells, the macrophages, the neutrophils,

produce an upregulated form of the enzyme if we have an infection. And that's how our body fights infections. We mobilize our immune cells. We go to the side of infection. and that we generate a lot of nitric oxide over a short period of time. And then that nitric oxide binds to the iron sulfur centers of bacteria, shuts down their respiration, kills the bacteria, and it prevents a virus from replicating.

So a virus can enter your body. If you have a good cardiovascular system and a good immune system, then your immune cells go immediately to the side of attachment, generate nitric oxide and prevents the virus from replicating. And if a virus doesn't replicate and propagate, you don't get sick from viral infections. But again, if you can't make nitric oxide, you become immunocompromise. You get the flu every year.

those people got COVID, many people died from it, you're prone to bacterial infections, and really immunocompromised patients are nitric oxide deficient patients. And I know you mentioned some of the reasons, the lifestyle changes, environmental changes that are associated with what's making us sick. In specifically nitric oxide, are there any lifestyle habits that suppress it? Absolutely. It's basically living the American lifestyle. No, they call that the American lifestyle.

This Western lifestyle is now gone global. It's gone to the east, to India and Asian. We got this pandemic of hypertension and diabetes all over the world now. So it's not just a westernized American issue. But no, there's lots of things. Then the other, to finish up on the previous question, there's also bacteria that live in and on our body that produce nitricoxone. And so when we start to think, to answer your question,

what leads to loss of its production, it's being sedentary. You know, exercise stimulates and activates nitric oxide production. That's why exercise is medicine. But if you're sedentary and you're not exercising, either you lose it or you use it or lose it. And so the enzyme becomes dysfunction. Number two is high carbohydrate, high sugar diet. Anything that leads to an increase in blood sugar is going to completely shut down your

microxide. And when you think about this, it's a complex science in enzymology and biochemistry. But an example I use, if you've ever spilled a soda or a glass of iced tea, sweet tea on the counter, then come back the next day, it's sticky. right. And so that's that's the sugar and the sugar is sticky. Or if you just spill sugar on the countertop or honey, it's sticky. So when we increase sugar in our blood, it sticks to proteins. And it glues things together. Glucose is glue, as the name implies. And so this excess sugar binds to proteins, binds to enzyme and makes them what they can't do their job. And one of those

is the enzyme nitric oxide synthase. And back before, you know, they changed the food guidelines. you know, the food pyramid was eat a lot of carbs, grains, sugar with very little red meat and avoid fats. And finally, we got some sense in the administration and they inverted it. So now you need to eat a lot of good protein, good quality fats and very little, if any, carbohydrates, processed foods. But unfortunately, you know, most Americans are eating a lot of processed foods. They're grazing throughout the day, eating, you know, three meals a day, snacks in between, we're overfed, eating poor food with nutrient, without any nutrients in it, and it's causing an increase in bloodshund.

And we have an epidemic of diabetes and metabolic disease. And so those are the big two on the enzyme, sedentary lifestyle and poor diet, high in sugar. And then when we start to look at what affects the bacteria, it's things like fluoride in the drinking water, fluoride in the toothpaste, and a septic mouthwash, you know, two out of three Americans wake up every morning and sterilize their mouth. And you see the commercials for Listerine or SCO, so that kills 99.9. percent of the bacteria in your mouth, and these companies are proud of that. When it's known in the scientific and medical literature that destroying the bacteria causes human disease, but yet these

companies are advertising, we're going to kill 99.99% of the bacteria in your mouth. And by the way, that's going to cause you to have high blood pressure. It's going to cause you to have erectile dysfunction. You're going to lose the protective benefits of exercise. And you're going to end the rapid rate of onset and progression of cardiovascular disease. And you're going to become a really good statistic. And by the way, we're going to be able to put you on a lot of medication that you're going to take for the rest of your life. We're going to make a lot of money off you. The lifetime value of yours is very, very valuable to that pharmaceutical company or that company that's selling you the listerine. And you become, you get on the hamster wheel and you never get off. And then the other one is

the antacids, the proton pump inhibitors. Those are the most deadly drugs on the market. They're killing people 40% higher incidence of heart attack stroke and Alzheimer's, simply by taking a proton pump inhibitor. These drugs were never approved to be taken chronically. You can now get them over the counter without a prescription. And people take them every day for 10, 20, 30 years, and it's killing people. They're dying, heart attack, stroke, Alzheimer's. These drugs should be eliminated from the market. They should be taken off the market by the FDA,

or at the very least put a black box warning on them because it's causing heart attack stroke in Alzheimer's. The data are undenial. And as I'm listening to you, I'm thinking of, like, we're talking about how the medical field people are trained, but then also thinking about how, as human beings, we have been conditioned to think of things in a certain way, of certain solutions based on what,

again, what we've seen on media, what we've been told by the people we think are experts or are experts. And one of the things you mentioned when we're talking about bacteria, especially with the mouthwash and talking about it kills 99% is the concept of microbiome, which when I learned about it, learning that we are more cells bacteria than we are human cells, like, it blew me away. I was grossed out for a little bit. But I think kind of thinking about that and realizing, no, you are more bacteria than

you are human cells. It just challenges you to kind of think what else do you think is healthy or is going to be healthy for you when it's actually not? No, that's right. Look, the human genome only codes for about 23,000 gene products. The microbiome, the bacteria that live in and on our body, which as you mentioned, outnumber human cells 10 to 1. Humans are 10 times more bacterial than we are human. But those bacteria are coding for 3 million gene products. And these bacteria are what we call commensal symbiotic bacterium.

They're doing things that we as human. can do. It's part of our ecosystem. And today, we know that every single age-related chronic disease is associated with some dysbiosis. You know, if you have dysbiosis in the gut, it causes neurological disease. It causes a lot of other dysbiosis in the mouth causes cardiovascular disease. And if you disrupt the normal flora, then, you know, the vaginal flora, women are prone to yeast infect. You kill the bacteria in the mouth, and we get, you know, this white coating on our tongue. It's fungal infections. It's yeast, and it's dysbiosis. So no one, you know, the vaginal. in the right mind would tell you to take an antibiotic every day for the rest of your life.

Because the science tells us that if you do that, you kill your gut bacteria, you're going to get systemic disease. So why are we still sterilizing our mouth every day? And why are these companies advertising and promoting and being proud of causing dysbiosis and wanting you to switch this mouthwash twice a day every day for the rest of your life? The only valid reason I can think of is because they want to make you sick. So they can sell you more drugs. It's because the science is undeniable. And I don't think these people have their head in the sand and not recognize what's going on. It's feeding their system. It's feeding their finances. It's feeding the economy of medicine. But it's making people sick. Again, it goes back to there's no money in curing. There's only money

in chronic treatment. And that's what these pharmaceutical companies are doing. That's what these consumer products companies are doing. Is they're giving you products to make you sick to become a customer for life. And we've got to do better. Patients and consumers have to get educated in form so they can confidently go to their physician and say, no, thank you. They can go to the pharmacy and say no, thank you, and don't buy that product. And then when customers and consumers start changing their buying habits, then these companies go away. And they have to pivot because nobody's buying their product anymore because you and I are educating them on the real science of medicine and health care. And I think this connects to the question I had asked earlier in terms of the average person,

like how much do you actually understand about medical findings about how? So when you say, educating themselves? How can we ensure that we're educating ourselves and we're not falling into the trap of seeing something that is said like their saying is valid, but it's actually not scientific? No, question everything. You should not trust. Don't trust your doctor. Don't trust your pharmacist. Don't trust the advertising on TV. In fact, I don't, I never turned my TV on because what I found was I was seeing all this misinformation because they tell you what they want you to know. They don't tell you the truth. The media tells you what they want you to know. And so I just turned. my TV off because I got fed up with it and I couldn't, it would upset me and I was getting upset

for things that I can't control. So I just go get, I turn my TV off. But no, you have to question everything. I mean, all you have to do is read the package insert. If a doctor gives you a prescription, please, please read the package insert and look at the side effects. Or if you're watching TV and if you listen, you know, a 30 second commercial for a pharmaceutical drug, there's about 20 seconds of that commercial that are side effects or things that can happen. And if you listen to that, no one in their right mind would ever take that drug. No one in their right mind with any sense of objectivity would take that drug. If you read the package insert or if you listen to the commercials. But, you know, there's a lot of information out there. And again,

it's very difficult for them to get properly educated and informed because, unfortunately, you can find anything you're looking for on the internet, whether it's right or wrong. And there's, look, medicine can be quite complex. And there's a lot of drugs out there. There's a lot of people with, you know, a lot of medical mysteries and things that have been untreated for many, many years. And it's typically not due to one thing. It's a multitude of things that are contributing to their chronic disease. But again, I think if you go back to the basics and just think about what am I missing, do a complete blood test, do an amino acid profile, do a micronutrient analysis, and see what your body is missing. And then take good, high quality supplements to supplement

what's missing. That's the purpose of supplement. Supplement what your body is normally missing. And then I tell people, you know, go see a biological dentist. Get a a CT scan of your jaw. If you've got any root canals, you have to get the root canals extracted because they're all infected. Give rid of fluoride. Stop using prescription medication. Work with your physician. If you're on medications, ask your physician to wean you off of it. Because if you give your body what it needs, your body heals itself, and there's no need for drug therapy. But, you know, go to reputable sources. You can go to PubMed and, you know, these are scientific technical articles, but you can read the science. You know, I provide resources only, I focus on nitric

oxide and that's it. And so, you know, I'd recommend people subscribe to my YouTube channel, Dr. Nathan S. Brian Nitric oxide. I mean, there's some content we provide that's outside kind of the field of nitric oxide because in one way or another, it may be directed. But, you know, that's a credible, reliable source based on my 30 years in science. And, you know, I'm not telling you anything to sell you products. I'm just providing you education information so people can make informed educated decisions and not be deceived or defrauded by these companies trying to sell you products that don't work. What happens to a scientist, the healthcare professional, when their findings or what they know will work,

challenges what is established? It's a very predictable path. First, the data is ridiculed, then there's violent opposition, and then it's revealed as the truth. And this is a quote by Schopenhauer in the 1600s, a German philosopher. But these are truths. These are fundamental truths, and these truths go through those three stages. ridicule, violent opposition, and then accept it as being self-evident. But, you know, it's also meant with, and so I've experienced all three of these.

But, you know, when you go through that, then you become a target. And people try to shut you down. I've been the subject of lawsuits. People and companies sue me. They try to take me out because this is very disruptive. And I've had companies sue me and threaten lawsuits if I test their cut products and reveal that their products don't work in terms of improving nitric oxide production. So this is a very very very.

very dangerous, if you will, proposition because I've had, you know, through litigation, I found out that there were, you know, attempts on my life, people trying to take me out and then, you know, break my companies, tying us up in litigation and spending millions of dollars to defend ourselves and defend our science. So it's not easy when you go against the system, when you develop and discover innovative technology that completely disrupt the entire healthcare system. It's met with violent opposition. But, you know, always like this, the truth is on our side and the truth will set us all free. And when we stick to that and we tell the truth and we advance the science and we have data to back it up, that's reproducible by other groups and we have safe and effective product

technology, you know, we're on a mission now and we're going to continue that until we change the world. And how will someone, let's say I'm thinking again, a scientist, a healthcare professional who's like kind of listening to this, how will they be able to maintain intellectual honesty when, with all this pressure? Because you can deal with that. Like it sounds like you've found like ways to deal with it. But for someone, they might be like, well, I have a family. I don't want someone to threaten me with litigation or whatever. Look, at the end of the day, I think it's courage, you know, but it's your risk tolerance too. I mean, this was a leap of faith years ago when I, when I did this. And fortunately, you know, I'd had patents. And so the University of Texas owns

my patents. And, you know, we licensed my patents back to the University of Texas. And so fortunately for me, I've been very blessed. I made a lot of money off my patents. So I didn't need my job anymore because I was making more on patentalities than I was being paid as a professor of medicine at certain times. So I was afforded that flexibility where if I had to step aside, step out of that environment because of conflict of interest issues, because of, you know, the restrictions put on my research program, then at least financially, I could afford to do that. And then the next stage is when you become an entrepreneur, you start companies, how do you productize those discoveries? And then how do you market in a way that's legal and ethical when

you've got all these other companies basically saying the same thing that I'm doing, that I'm saying, and can say. But you just have, you know, for me, and it's, I think I'm a little bit different because I'm the discoverer of it. I was the original researcher. I developed the products. I know the science better than anyone out there than any other company out there. So, you know, I just, I've been probably hardheaded and a little bit stubborn most of my life. And I just keep to it. And I keep going. And, you know, I've survived things that would have, you know, sunk 99% of the ships out there and, you know, bankrupt most companies and most individuals. But, you know, here I am, still going. stronger than ever. And, you know, we're, again, we're not going to stop. But it's very, very difficult.

You have to have a lot of faith. You know, I'm a very faithful person. I wake up every morning with gratitude. I pray every day and, you know, read scripture. And I know that God has a plan for me. And I try to listen to him and, you know, work his plan. And what do you think one question, every person should start asking about their health? You know, if you're, the human body, we should wake up every morning and feel good, no matter how old we are. I'm 52 years old, but I feel better today than I did when I was in my 30s. And the reason that is, is because I pay attention to my body. If I wake up and my body's telling me that I don't feel right, then I go back and I do inventory. What did I do yesterday? What did I eat? Why am I, what is it affecting me this thing? Did I get good

sleep? So you have to take inventory of what you're doing. And I tell people all the time, keep a food diary. Anything you put in and on your body, whether it's something you drink, whether it's a, a cream, a lotion, supplements, drug therapy, anything you put in and on your body, write it down. And as soon as you have exposure to it, write the time. And then do that for, you know, a month, two months, 90 days. And then every day wake up, how you feel when you wake up. Do you have diarrhea? Do you have gastric distress? Do you have a headache? Does your body ache? And then start take an inventory. And what happens is a pattern starts to develop. You got to realize, I felt bad this day, you know, maybe six, seven, eight hours after I had a pizza buffet or something, as an

example. And then you've got to move. You know, we're designed to move. And so I wake up every morning and I work out. No matter where I am in the world, I work out every single morning as soon as I wake up. And then usually I'll do an infrared sauna. I do cold plunge. I do an LED lightbed and I get 20, 30 minutes of direct sunlight day. But I think that that's the most important thing you can do is take inventory of what your daily activities are. And if you go through the day and in your diary, you haven't done exercise or movement or even practice some deep breathing. And you're eating throughout the day. You're grazing, putting something in your mouth every two to three hours.

That's unhealthy. You need to do at least an 18-hour fast every day. And really, for me, that's been the biggest transformation. And that's cost savings, by the way, right? If you only eat between noon and six, eat your last meal at 6 p.m. And they don't eat until noon the next day. And then when you do eat, high-quality protein, good fats, limited or no carbs, and throw in some green leafy vegetables.

And then it will change your life. You'll start to lose weight. Your insulin resistance and diabetes will go away. You'll feel better. And then give that a week or 10 days and it becomes a habit. I've been doing that now for two years. And it's an 18-hour fast every day. People think it's difficult, but it's not difficult.

If you eat your last meal at 6, you go to bed at 10, you wake up at 6 or 7, then all you got to do is wait another 4 hours to eat lunch. Anybody can do that. Dr. Brian, for the listeners who want to connect with you, connect with your work, where can they find you? You know, I would recommend this is my latest book called The Secret of Nitric Oxide, Bring the Science of Life. This book tells the whole story of nitric oxide, how it was discovered, what led to a Nobel Prize. But also in there chronicles my personal journey, where I came from, my education, my background, my discoveries, which allowed us to, you know, bring to market good product technology.

But you have the secret of nitric oxide, you can find it on Amazon, Barnes & Noble, or Nathan'sbook.com. There's a link. As I mentioned, I encourage you to subscribe to my YouTube channel, Dr. Nathan S. Brian, nitric oxide. Follow me on Instagram, Dr. Nathan S. Brian. Same on LinkedIn. Twitter on Dr. Nitric. Then for those interested in our product technology, it's N-1.com. It's the letter N-N number one, letter O, number one.com.

Not N-101.com. If there's one key takeaway, you are hoping that every listener leaves this conversation with What would that be? You know, I think if there are different reasons people are listening to this particular podcast. It could be for, you know, to develop a resilient mind. But, you know, for that audience, I would say, if you believe in what you're doing, stick to it, don't let the other people tell you your dreams. You can't do what you're trying to do, that it's impossible.

I've been told, you know, for the past 30 years, what I'm doing is impossible. You can't make a solid dose form of nitric oxide gas. That people who come after me and try to shut me down and try to discourage me and tell me and put me in financial strain and I just I have a resilient mind and I kept going. So stick to it. Never, never, never, never give up or give in as the words of Winston Churchill. And then for those who are dealing with health problems, investigate nitric oxide as a potential cause of your symptoms and your illness, but also look at it as a potential solution. Because as we discussed earlier, the loss of nitric oxide is what leads to chronic disease. And if we can improve the natural production or take products that

recapitulate its production and signaling, you know, I've been doing this for, decades now and we see transformational results and changing people's lives every day and there's nothing more gratifying. Thank you so much for sharing your insight to your perspective, a wealth of information. Really appreciate you

taking the time to have this conversation. Well, thank you so much for having me. It's great being with it. Thank you for listening. Continue strengthening your mind by subscribing and listening to our other episodes.