The Skinny Confidential Him & Her Podcast - How To Protect Your Cells: The Science Of Disease Prevention, Healthy Aging & Building A More Resilient Body Ft. Dr. John Gildea

Episode Date: August 6, 2026

#995: Join us as we sit down with Dr. John Gildea – Johns Hopkins-trained PhD with 60+ peer-reviewed studies & two decades of research on how targeted compounds protect cells, clear environmental toxins, optimize metabolism, & build resilience as we age. As a molecular biologist, Dr. Gildea serves as Chief Science Officer and Formulator at Mara Labs, where he leads the scientific strategy, formulation development, and research direction behind the company's cellular detox supplement formulations. In this episode, Dr. Gildea discusses exosomes and stem cell effects on aging, environments which cancer growth depends on, covers cancer prevention, & shares practical recommendations on how to build a more resilient body in a toxic world!    To Watch Episode #945 with Dr. John Gildea & Mara Labs click HERE   For Detailed Show Notes visit TheBossticks.com   To connect with Dr. John Gildea & Mara Labs click HERE   To connect with Lauryn Bosstick click HERE   To connect with Michael Bosstick click HERE   Read More on The Skinny Confidential HERE   Head to our ShopMy page HERE and LTK page HERE to find all of the products mentioned in each episode.   Visit http://mara-labs.com/skinny to get 25% off for the next week and to learn more about Mara Labs and Dr. John Gildea.    This episode is sponsored by The Skinny Confidential Shop your nightly ritual now at https://shopskinnyconfidential.com.   This episode is sponsored by Squarespace  Go to http://squarespace.com/SKINNY for a free trial, and when you're ready to launch, use OFFER CODE: skinny to save 10% off your first purchase of a website or domain.   This episode is sponsored by ARMRA Go to http://armra.com/SKINNY or enter SKINNY to get 30% off your first subscription order.   This episode is sponsored by ThirdLove Use code BOSSTICKS15 for $15 off your first purchase at http://thirdlove.com.   This episode is sponsored by Hiya  Receive 50% off your first order on any of their products. To claim this deal you must go to http://hiyahealth.com/SKINNY.   This episode is sponsored by Polymarket Polymarket is now available in the U.S. App Store – you can trade on culture, entertainment and more, all in one place. Download the app and use code SKINNY to get $20 to trade when you make a qualifying $10 deposit.   This episode is sponsored by Truvia If you're looking for a better way to enjoy sweetness with zero calories per serving, you really need to try the newTruvia® Allulose Plus Stevia Sweetener & Monk Fruit Sweetener – available online and nationwide at Kroger, Target and your favorite local grocery retailer.   This episode is sponsored by HERS Ready to reach your goals? Visit http://forhers.com/skinny to get personalized, affordable care that gets you. Produced by Dear Media

Welcome to the Bostics, starring Lauren Bostic and Michael Bostick. Together, they are the Bostics. I have never spoken to someone on this show who is so smart when it comes to cancer research. I mean, I was blown away at the first episode you were on, and you and I have had conversations off air. What are you seeing when it comes to stem cells, exosomes as it applies to cancer? Are you seeing anything with that? I don't think it fits into kind of like a treatment bucket. But I would say that it fits into a general idea of cancer is very much age dependent.

And I mean, I like the analogy. My wife's very good with analogies. She teaches 10th grade biology boys in high school and they need something that grabs their attention. So she always does these analogies. then I think a really good one for this topic would be if you had a seed, say this seed was similar to a cancer, right? If you take that and you just put it into a garden that doesn't have anything else in it and you just put it into that garden, it's going to grow, right? and how fast it grows and how wild it grows after it germinates, you know, is dependent on this seed. But if you try to take that same seed and just throw it into a forest that's been there,

you know, primary forest that's been there for a thousand years, every niche, every little place where that would land is already occupied by tons of life that's in balance, right? So part of that balance is how each of the cells are talking to each other. You know, tons of research coming out that strong muscles release a whole bunch of exosomes and you were saying peptides and things like that that talk to every other cell in your body. Really interesting ones recently talking to your fat cells where makes your fat cells be able to drop their fat faster. So you're saying that muscle mass, potentially has preventative abilities when it comes to growing cancer because it doesn't like to

grow around the muscle mass. Is that a dumb way to say it or is that correct? It's correct in that if you if you talk about your body being like that mature forest, everything's in balance and everything is functioning. Is that supposed to be? And so maybe it's helpful to have the opposite of that is most people know whether they're healthy or not. If you're, if you're body is sick and things like if you're stressed all the time, you're always thinking about negative things all the time. It affects your body in so many different ways. That's psychosomatic. It's gigantic. But that's creating this environment like you went into the middle of the forest and dug up 100 acres in the middle of that. It's not balanced anymore. That is going to be able to have

you know, these bad seeds be able to grow in that area. What's the craziest thing that you've seen when it comes to cancer? Maybe something that is even almost a miracle, because you've seen it all. Yeah, I mean, there's all kinds of ones. And I guess the way to frame it the best way is to say, I'm always surprised by the response. some of the worst possible scenarios where I only get involved after medicine has completely stopped working. But you just try something as simple as, I'll think of one example. One good example is there was a lady that she showed up with metastatic pancreatic cancer.

And they basically said, you know, I have a couple months. And they showed up in our kitchen and while we were talking, we were just talking about things my wife does. one of the things she found super helpful was juicing. And she said, I don't eat anything green. I don't ever eat any vegetables or anything. And then right while she was there, like a little light bulb went off and you're like, you think that is possibly, you know, why? I was like, I don't know, makes sense to me. Like, that's a pretty big hole in your nutrition. And by the way, eating fresh vegetables and fruits come with their exosomes. And that's why, you know, right out of the ground, two days from your CSA is better than anyone. Anyway, so we got her to agree to try and juice.

Did some other things, too, some natural compounds that we know are generally good for pancreatic cancer specifically. And she completely reverted. Zero, nothing. Wow. This is where I get confused and maybe you can enlighten the audience. The pesticides are being sprayed with so many different things right now. You're seeing it everywhere. You're seeing there's there's something going on right now. I heard a friend talking about something where they're spraying so many pesticides and all these kids are getting cancer from the pesticides. And then I hear this juicing thing and I'm like, how do we clean off our vegetables and our fruit to make sure that the pesticides aren't on it? So we're actually not making it worse. Does that make sense? It's a perfect question. And it's a difficult

answer too because it's the same question. People say, can you just go with me to the grocery store and teach me how to grocery shop? And it's always shocking when I say, don't get your food from a grocery store. Right. That's strange for a lot of people. They think that there must be good food in there. But all the food that's there is, it's there because it can have, it has good shelf life. And so it's not even the same food. You're selecting for things that last for a long time. And the food that you should be eating is stuff that goes bad fast. Like if bacteria don't like it, it's probably not great for you. That is genius. So you're saying if you can buy vegetables and fruits at the farmer's market, that's what you want. You want the food that gets bad really fast.

The problem is, as a society, we've moved so far away from those kind of opportunities. Everything is mass produced, everything is mass stored, everything is built to sustain for a long period of time, which is how we've largely been able to feed a lot of people, right? So not everybody has access, but I think the price we're paying as a society is that we are ingesting many things that are not designed to be ingested by humans. And I think it's taken many years for us to kind of realize that. And even now, people are still hesitant to say, you know, like a lot of people still don't believe that some of these additives and some of these chemicals and some of these things that we use to preserve are bad for us. But clearly people are starting to have bigger,

the greater and greater health issues. Yeah, I mean, that's a fantastic framing. Like, you would only do that if you had a really good reason to completely excise yourself from the normal food system. But I think, you know, if you're really sick, and especially, you know, say you had a loved one that was sick. you know, like no stone unturned. Let's do everything, you know, go to counseling, find out what, you know, what's going on in the brain that might be, you know, run amok. Everybody has those stray thoughts and, and, you know, do it, do it all. But the pesticide question is, is a great one, because the way I always frame it is it's designed to kill something. It's a living something that

you're trying to inhibit. And if you've looked at the molecular level, you know, like I do when I'm using antibodies against this protein or that protein, it's always astounding how similar they are. Explain when you say when you're looking. You're a researcher by trade. Researcher, yeah. The little world that I live in is something that's very hard to describe, but a lot of it has to do with affinity and separation.

So if you take a fruit fly, here's a good example. we were looking for a part in the fruit fly that keeps cells from metastasizing, right? And or something that helps something metastasized. So we set up a, we set up a series of tests. They're very simple. So at first we found an antibody from humans that blocks an enzyme called gelatinase. It just cuts through basement membrane. So the idea was we thought, oh, if we can use this antibody that blocks gelatinase,

maybe you can block it in fruit flies because it sees the protein. This is a fruit fly and a human. You wouldn't think those two proteins look at all alike. But those two things are alike enough that an antibody that fits shapes, was able to see the collagenase. We had a test for metastasis in fruit flies. If you add the antibody to it, it doesn't metastasize. you can take any cancer cell in fruit flies that is a tumor and you can just plunk it into

another abdomen of a fruit fly. No one cares if you do that. Pita wise or anything. You never know. Yeah, maybe they will now. But they grow the cancer and the abdomen, but they never die. The host that you put into never dies. But if you take the same tumor and cut it in half and put the half into the abdomen, very often it invades the fruit fly and kills it. But if you do the same thing and add the antibody that blocks that one enzyme, it blocks metastasis. And just so I'm clear, the antibody is the broccoli sprout? This in this case is just an antibody. Your body makes antibodies to fight disease, and we use it in biology as tools to grab things, inhibit things.

you know, all the biologics that are out there right now for, you see on the, on TV, it's advertisement. This antibody blocks this part of the immune system and helps with psoriasis. But there's all those kind of things. And just to come back to what you were talking about earlier is like I brought that up that enzymes and things are the same between, you know, very different organisms. You know, they're trying to kill a bug or kill a, a, a wee. but they all have a lot of the same mechanisms as us. And so there's very few things where it just kills the thing that's a target. It's actually it kills everything but probably kills the insect.

It's targeting a little bit more. So every time you do that, that same pesticide is messing up something in us. So what actually is cancer and what causes it and what are some things that we should be thinking about avoiding if we want to limit the possibility of getting cancer ourselves. Yeah. Prevention. It's a really fun topic for me because I look at cancer very different than most people. So the initiation of cancer is you have cells that are been, there might be benign. They're just growing into a bunch like a wart or a mole, right? So that's not cancer, but why? Well, in that case, you're trying to prevent cancer.

If you see a mole and you're like, oh, I'm worried, I'm going to get cancer. It's these cells growing quickly, but what is it that makes it go from that little bump into something that you call cancer? You're preventing progression. And so at every stage, I'm always thinking about blocking progression. So at every step, if you have a little bump that's on your breast and is growing a little bit, what are you blocking? you're blocking the next step. So I paid attention to that for a long time studying cancer progression. So for me, you don't usually die from the primary bump or lump. It's from it progressing. So when you say preventing cancer at all, you're just preventing the first step where it doesn't start

growing. And what we were talking about earlier is having, you know, the forest be inhospitable. what creates that forest. And so if you're trying to use that analogy for your body, that forest are exactly the things that you guys point to all the time. What is hormesis? What makes you stronger? You do both. You get nutrient-dense food, all the nutrients,

and exercise so that they're incorporated that makes everything stronger, all your tendon stronger, all your basement membrane stronger, all your muscles. it's using all the energy that you're that you're taking in your body. You're making that super strong forest that if you throw a little cancer in there, it's not going to grow. And one of those things that you found that helps prevent it is broccoli sprouts. I've been going to the farmer's market, getting my broccoli sprouts every week.

They sell out by 930. It's crazy now. Wonderful. Everyone wants the broccoli sprouts. I mix them in my son's eggs. He's eating his broccoli sprouts. And it's kind of like become this phenomenon. What specifically have you found, and I know you said this on the other episode, but I would love to remind the audience in broccoli sprouts that does prevent the cancer. Yeah. So there was a whole institute at Johns Hopkins where I got my PhD. And so even if I didn't want to hear about it, I heard about it all the time because it was the early 90s when, when, um, the original discoveries for the active ingredient in broccoli. What does it do? And so while I was there, that was all sort of being discovered. And the active ingredient in broccoli is called sulfurophane. And this single molecule is, how would I frame it this time if I wanted to talk about it?

When you talk about what the inside of a cell is versus what's outside of a cell, the outside of the cell is oxidizing. sort of outside of living cells, everything sort of oxidizes and degrades. It russes and it falls apart. You know, you put a house out in a field and if you're not maintaining it all the time, it turns to dust. And, you know, a pretty short period of time, that's entropy. That's all happening. That inside a cell, it's a reducing environment. And that's the only place where it doesn't go that way. It actually builds up sort of on its own. And so part of the difference between those two states is oxidation or reduction, you know, whether it, you want electrons or you want to give them up. But the inside of

the cell is this reducing environment. And so a lot of the systems that respond to stress are responding to oxidation. So there's a whole bunch of little pieces that are on proteins that are sensors. They're sensing whether it's still reducing in there or is it oxidizing? If it's oxidizing, then it turns on a system to correct it. Well, so forophane is this strange molecule is that it's not, it's not, you know, a free radical. It's not an oxidating, you know, material. It's, I would say, kind of artificially, except it comes from nature. It goes into those same spots and turns on your

systems to protect yourself. And it turns on a whole bunch of them. We talk about one transcription factor called NRF2, that turns on antioxidants, meaning you make a bunch of enzymes that suddenly start mopping up all the free radicals. And then it also turns on two stages of detoxification called phase two and phase three detoxification. It goes and mops up all the toxins that are around and then shuttles them out of your body. So if there is, if you want to ask me, there's one thing that you want to prevent cancer with, it would be sulfurphane. Wow.

It turns on so many things that it gets, it mops up toxins. So, you know, you still want to reduce the amount of toxins that are going in your body. But then also, because we're in this world, there's so many toxins everywhere. Are you going to eat Bond and my broccoli sprouts? Because we eat it. We eat Bond and I take your, I take the Moral Labs, sophoraphame pretty much every day. Yep. We love it.

I have it. Funny enough, my doctor did a swab test on me and she said that would be a good thing for me to incorporate. Just like, fantastic. Yeah, she's great. She said that about the baby, too. She said specifically for the baby that he needs those sprouts. So cool. Yeah. There's so many things in medicine that work that I still don't know the mechanism about, but usually when I look into it, if you have a really clear signal that it's helping, it turns out to be real. It's just we haven't studied it in the lab. Maybe this comes

right from science, but I don't know. Speaking of medicine, what do you think, is a cancer researcher and somebody who studied this for a very long time. What do you think the modern medical community gets right about cancer prevention and treatment? And what do you think could use an update? I think probably people would be surprised that since I, you know, I function in with one leg in both in academic medicine and in the supplements industry, that those two places are super obvious, like what one is really good at and what one is not so good at. And I would say that in medicine, one thing you have to really think strongly about if you're,

if you're have cancer and you're thinking about going alternative, is to find a doctor that is, that's open to possibly doing other things. Because you don't want to miss out in the testing, imaging, you know, looking at biomarkers. If they have a treatment that works, look at the statistics because you can put that in your back pocket because it's true. They spent billions of dollars proving it does this to this kind of cancer. And they should be able to show you those statistics clearly. And that's what I would say is absolutely essential is you talk to your doctor,

be super open about it and say, I would like to do alternative things. And I will listen to you if you have reticence about this natural compact. for this treatment because they're more and more now being trained in that area. Are there things that are prescribed generally that have poor statistics that is, that they're still prescribing that you would maybe have people, I want to be very careful here, that you would have people maybe look a little bit more into or avoid or at least ask more questions. Again, like I want to be careful because I'm not a doctor. Yeah.

And I know this is a very touchy subject and people's lives are on the line. But are there things that maybe you would say, hey, ask a little more questions. do a little more research, look into those statistics a little bit more. Right. And yeah, since I'm a PhD researcher, I look at it differently and, you know, I'm, I'm not prescribing things, but I have a pretty clear picture of that. I think the biggest, I think the biggest thing that's missing in oncology is just this general framing is that if you, if you show up with a cancer, it's a bump or a lump, right? And it's growing. And they'll they'll give their chemo and other therapies. And the primary readout of that is how big that

cancer is. And it'll shrink. And you'll never convince an oncologist that what he does every day doesn't work because he sees it every single day. So don't even worry about you're trying to convince a doctor that he's missing something because I think most of the time it'll be a, you know, it'll be not a good thing to try and achieve. But what you should work together about is that there are cells within that tumor that are the ones that become metastatic. And it's a subset of the tumor that is there that goes on to progression. And so when we talk about preventing cancer, even in that scenario, I want to talk about it as preventing cancer because you're preventing that subpopulation within the cells from becoming more aggressive. So is that the example you gave of the fly where if you let you.

left one intact and put in one fly somebody, that fly could potentially live the rest of his life. In another instance, you take that same thing, you cut it or biopsy it and then put it, and then that kills the host. Yep. And so that cancer has some new abilities. And that is, you've done something to it.

So it releases, it's too big a subject to talk about, but basically collagenase got upregulated. And so, and released so that it can chew through basement membrane and travel to new organs. And so that preventing the next step is super important. And so it's a little bit, I'm framing this is really important because if you, if you, everybody shows up in your door, you identify the cancer, you biopsy, you find out, you know, it's genetic makeup, you put it into a category, and then you you give it a designed system to try and kill it. That's what standard of care is. That's what you do when you go to your oncologist. But at the end of that,

the people that progress and die, they all have resistance to drugs. You've defined what what cancer is that kills you. It's things that bypass standard of care treatment. So I always say in that scenario, oftentimes as a primary tumor, you'll go, you get your bucket that you put your cells into. This is the kind of cancer. This is the stage. This is the grade. This is your biomarker. You get it imaged. And then you do your chemotherapy and then you're sent home to watch and wait. Well, while you're watching and waiting, let's do some stuff that you know from the literature. Let's go back and, you know, reap the benefits of these, you know, trillions of dollars of research and say, oh, these are the processes that are necessary for it to

become aggressive. And then judiciously apply natural compounds that are known to interact at those stages. Do you think it's a one-size-fits-all? And I think I know the answer because I've talked to you off air, but do you feel like this one-size-fits-all of chemo radiation is the right way? It's hard to do personalized medicine in that scenario. Yeah. And so I think it by design is standard of care is one strategy. So there's not a lot of personalized medicine in there because legally you can't do anything else. And, you know, getting your oncologist on board to say, I don't know whether you believe it works or not, if there's any hope in doing this other thing, but would you be open to applying natural compounds that affect pathways that are in the

literature. Does that have to do with money? I'm not sure the root cause of it is. I mean, most of the oncologists I talk to, I know a lot of, you know, medical-related people. They're super honest and hardworking, amazing people, but they don't believe natural compounds have much efficacy. And so they're not reading that literature. I would say they're reading clinical studies because that's, that's the only study that they can use that information and try to apply it. This is going to be a really dumb analogy, but I'm obviously in the world of medium in the media business. And I was on with somebody yesterday who's been basically deploying their entire ad budget for close to 40 years now through television. And they've done almost no digital media. And in their mind, it's a weird,

but in their mind, the only thing that works is television advertising. Yeah. And there's no, there's no convincing that any of these new channels could have any impact. And I look at it in a way where it's like if something's been working in driving results for a long time, no matter how measurable or how good, but if that's the only results you've been measuring for 30 or 40 years, it's hard to say, hey, that you've been missing something over here completely, right? And I think that happens in a lot of fields outside of media. I think it happens in medicine until, until information comes out. That's so undeniable that you're like, oh, I have to. I think it happens in parenting. I think it happens with diet. I think it happens with food. I think it happens with

basically everything until you get such undeniable evidence that you're like, oh, I actually have to pay attention to that. Yeah. I like that a lot because it really tells you that they are willing to change. It's just, it takes a lot of momentum to change something. Right. And, you know, slow moving things sometimes is safe. You know, you don't want to do radical things that have no evidence at all. And, you know, that's just how life works, I think, is there's always somebody that's way ahead. And they have to convince people that their strategy is a good one. Just in general.

Yeah. Yeah, no, I think the, I think it's always, things take, always take a lot longer than people think. And it's why when we talk, when we talk on this show about things that are maybe newer or cutting edge, I understand the pushback sometimes from the audience and from some of the critics, you know, like that question some of the information because I've seen the pattern. too many times, right? We've been doing this show for 10 years. The early days, I had to convince people that podcasts were going to be important media

outlets. People would say, like, why the hell are you doing that? And even through the history of the company with advertisers, a lot of it in the beginning was like, tell me why I should even take this medium seriously. Then it was, hey, I need to understand this more. Now it's, oh, shit, I miss this. How do I do this? Because all my competitors are, right?

And I think that that's everything in life. Like, people will push back on something that is new that changes their way of life that calls into question, maybe some of their strategies or some of their thoughts. Yeah. And if there's one thing doing this for this long has taught me is you can't ignore some of those early signals. It's better to be early than late. It's better to be like ahead of the curve than trying to catch up.

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that are part of metastasis, right? You would have thought, oh, there's companies out there that could use that information and just make a drug and it would work the same. I did it genetically. You put a gene in, take a gene out, and prove that that was how it works. here's 26 years later. No. Nope.

No one's going after that, but there should be. There's a quote that I've said on the show. It's the second time I'm saying it that I love so much. It's from Henry Ford. It said if you would have asked people what they wanted, they would have said faster horses. Yeah. I think about it all the time because sometimes you just have to,

you just have to bet on being right and wait for the world to catch up. But I've also learned you can't fault people for not getting it right away. Sometimes people, especially entrepreneurs or thought leaders, or people pushing new alternative therapies or information, they get frustrated because people don't jump on and believe them right away. Are you talking about me? No, I'm talking about everybody. I'm talking about everybody.

I'm talking about everybody. But I think it's just the way of the world, right? It takes time for people to evolve and adapt and shift and change, right? That's a great topic to change because I would have been that person too. I was like straight-laced, geneticists, academic medicine. I would never have ever thought about a natural compound, except, you know a little bit of my history is right when I was publishing these big papers, my wife got breast cancer, and then I started reading, you know, what was being offered my wife,

what was her chance or surviving five years? And I freaked out. Like, you know, I started thinking outside the box, and I think that's how it happens. It forced you to. Yeah, I had to. And so in order to, for me to use what I'm good at is understanding biology and processes and self-physiology. I had the ability to do something about it where, you know, there's these papers, you know, here and there and elsewhere showing natural compounds affect these pathways. And I was like, okay, well, that's within my purview. I can play with natural compounds. I'm allowed to do that.

And so I started finding out the problems with them. And they still exist. Like the majority of things that are out there don't get enough of it into your bloodstream to affect it. So in that respect, you know, a lot of oncologists are correct. It doesn't move the needle if you don't get enough there. And what's the general strategy? So I write it right off the bat was like I had to do screens. I had to use what I was good at. So I would get, I got my wife's cancer cells, grew them in a lab. We tried to start a company through 60 or 70 natural compounds on it, found what killed her cells. Like, wow, this is.

crazy. I take a normal cell and I take a cancer cell. I put a natural compound on it. This one kills it at this concentration does nothing to a normal cell. I do the same thing with chemotherapy and there's very little difference between those too. Did she do chemo and radiation or just did natural compound? She did do chemotherapy because I don't know if you know this about the system is that as soon as you find cancer there's like a quick step like you have to do this right away. You have to do this next, you'd do this next. And I didn't have enough confidence to say no. So we were already in and doing chemotherapy before. I even found out the statistics that it wasn't that good for her. Looking back, would you have done it? I think I wouldn't have, not knowing that there are other

tools that are better. But, you know, for sure at the time, I didn't have them. I shouldn't have, going back at that time. If I tried to put, have her take curcumin or something, you know, it still would have been 0.02% bioavailable. There's no chance it would get. It was, you know, a hundredfold, not concentrated enough to affect cancer. But, you know, that's sort of learned from, learn from my mistakes is when that happened, suddenly I found out what the problem is. The problem is these natural compounds aren't at high enough concentration. So, you know, we started finding out about IVs. You can go and get an IV of curcumin.

And that gets to a concentration that's high enough that was in that range. So it's not that the supplement is not the correct supplement. It's that the supplement company may not have the great enough amount in their supplement that actually gets to you in an effective way. Yep. So the compound itself could work, but there's studies don't enforce that because many people are taking things that actually don't deliver enough of a dosage. is that correct? Yep. Yeah, if you were able to just go in and measure that amount that's at your cell

that it has to get to, it's nowhere close. So quickly then, if you could give one piece of advice to the person who feels completely overwhelmed by toxins, health information, just doesn't, don't know where to start, they're overwhelmed by the medical industry. What would you tell that person? My goodness, that's such a great question. There's a lot of things you can do when you're facing cancer. And in this scenario, we're saying, how would you, what would you do to prevent cancer, right? So my one-two punch is always, eat as toxin-free of food as possible. So radically change your diet. And then the next thing is eat nutrients-dense food. So you have all the micronutrients. That's the baseline. From the farmer's market without pesticides, not the market.

From the best sources that you can find available around you. And then also electrolytes. I mean, a lot of people are walking around to fish in a whole bunch of different electrolytes. It's interesting. I've heard that. I've never heard that in relation to cancer prevention. So in the case, there's a really good example of that the guy who invented the test for carcinogens, Bruce Ames. A very interesting guy, super interesting story, but his first part of his life was detecting chemicals that are carcinogens. They make cancer. So he developed that test called the Ames test. And then later in life, he found out that all you, you have to do is be missing one nutrient from the whole cornucopia of things that you need

to be healthy. And you can get the same effect. You get genomic instability. You get reactive oxygen species. It looks just like a carcinogen, just like a toxin. And so the last part of his, of his life died in December, 2004, you know, but his legacy lives on is that all you have to do is miss one nutrient. So he just, like one of his early experiments was just take out magnesium. You get sick and all kinds of things fall apart really fast and it would be along the lines of going down the road towards cancer. And so it's a pretty unknown thing, I think, that missing a nutrient is very similar to a toxin. And I think they're both the same thing. is a toxin makes you use up nutrients at a different rate.

So even if you're eating nutrient-dense food, you get a toxin. It's going in and disrupting some system, just like missing the co-factor. So alcohol is a perfect example of that. Excellent. Yeah. Speaking of toxins, what's your opinion on cleaning supplies, these crazy cleaning supplies that are out there? People are sleeping on some of these detergents all night long, nine hours a day, breathing them in and then they're cleaning their table with Windex while they're eating their food

or after they're eating their food. What's your opinion there? Yeah, I think there's a couple really big ones in there is why are only carcinogens known to be carcinogens if you eat them? You're allowed to put carcinogens in skin care products. They're in there. You can put it on. It's fine. You're not, you're not eating it. You can breathe it in. You can breathe it in. They don't count that. Yeah, put it, slather it on your clothes and then wear it all day long. A cleaning supply is a carcinogen. Most of them have some known carcinogens. Yeah, what he's saying is that they only classify them as a carcinogens that's harmful

to your body if you're ingesting and eating it. But if you're wearing it on your skin or smelling it, like, why are we not classifying it? How is this legal that they're able to, like, clean all of our plates and our forks and our silverware and restaurants and all these things and spray all this stuff and spray pesticides and spray for mosquitoes outside and all these things all around us? but we're not allowed to eat it. It's confusing. Yeah. And it gets inside. It's not, you know, barriers are kind of the newest, the newest component of hallmarks of health and hallmarks of cancer is making good barriers

is your resistance to that. You know, if you are wearing clothes and your skin is perfectly healthy, that's a serious barrier to anything that's on your clothes getting in. But that's everything. I'm so passionate about this subject. It surprises me sometimes. when you notice it and you become aware of it, it's so crazy that all these little kids have it all in their face all the time, no matter where you go, in any artificial environment. And I'm talking from Disneyland to a restaurant to in the home.

Like, it's so crazy to me that it's everywhere. Again, one of the big takeaways we get from having conversations with people like yourself and others on this platform is that you really have to not only be your own advocate in every situation. But you also really have to be on guard and you have to be aware of what is around you. And your kids. Like I think the biggest eye-opener, and again, like, this is not a conspiracy thing. I think largely this has been proven over the years, especially now with a lot of information that's come out post-COVID, is just because it's on a shelf or in a store or being sold by a company does not mean that it's good for you, even if people say it's good for you.

Right? Like, you really, like, there's a lot of things from a regulatory perspective. in this country that would not fly in other countries because of the way that they police their products. But here, you really do have to pay attention yourself and be aware of what you're ingesting or putting on your body or wearing or cleaning with. You can't just blindly accept that it's safe. I think even if you go into a supermarket, and I've done this before, like say you go into Target and you walk down all the aisles, when you get to that cleaning supply aisle, you feel it in your nervous system. You can feel a shift. It's wild. And you, I, You almost can just feel it disrupting your hormones.

I don't think you can unless you're aware of it to begin with and unless you've largely eliminated stuff. So a lot of people, like I grew up in household with a lot of those supplies. My parents didn't know better. And I think many people for our generation did, especially we're a byproduct. I think all of us are a byproduct of that mass market generation, right? Where we were sold a lot of things. And it's not until you start removing some of these things from your environment.

You become aware of them. Like now when I smell artificial cleaning supplies or candy, You don't even wear colognes or deodorants or things like that. You kind of notice how many things it's masking. When you get rid of it and then reintroduce it, it almost like hits you like a 10 pound weight in the face. You guys probably from fasting and probably changing diet somewhat to try and reduce sugar is a super good example of that. Like the less and less simple sugars you eat, you end up getting insulin sensitive, right? So slowly, that's a really important thing for cancer is you want every cell in your body very sensitive to insulin so that it doesn't take very much to draw glucose into your body and then your body you burn it up.

So fasting is important when it comes to prevention for cancer. And also this whole resetting of insulin sensitivity because it's really the difference between the cancer or the cancer that's about to form and your cells. cancer can be detected by how much sugar it takes up. It's like sevenfold higher. That's what the PET scan is. It uses sugar more readily. It's super insulin sensitive. But if your cells are not insulin sensitive,

you have to have a lot of sugar and a lot of insulin in order to get the sugar inside your body to run. That cell over here is going to be ahead of you. It's going to take that insulin and stuff its mouth full of glucose every time. and that's the system where you're setting up a scenario where cancer can grow. And so when you as a person like you guys are doing is fasting and eating low sugar in general, when you go and you do that binge, you have a cake or something or whatever, like how bad it feels to you get so much sugar into your body and you're so insulin sensitive,

you'll dump a bunch of insulin and then it can drive your blood sugar so low as a as a as a as an overshoot that you can have low blood sugar and really feel horrible um so that's an instance of it where you become sensitive as you as you're missing seeing that thing it's it's a general phenomenon of how your body works is you know wants to it wants to use less and less of things and um for cancer prevention that's a really important one is to get your insulin levels low keep your blood sugar levels low and it makes the difference between your normal cells and cancer cells big. And so I think, you know, that's a fantastic example of if you stop in your home having scents and all these things, you go into the grocery store and suddenly you're sensitive

to that aisle. You're like, oh, that's evidence. I am getting rid of probably a whole bunch of toxins and I'm super sensitive to that now. Your body's trying to tell you something. Leave. Yeah, get out of this row. Dr. John, I brought you the skinny confidential mouth tape because you did tell me off air, I hope we can talk about this, that mouse breathing is related to prostate cancer. Can you speak on that? Because I love me some mouth tape. Man, yeah. I think so many people are becoming aware now that as you're aging, you're having problems with breathing at night. And there's a lot that. There's a lot that goes into that. But basically, if you're having bouts of not breathing very well, if you get a meter that measures it, you can see during the middle of the night,

you get a bunch of spikes of your oxygen dropping very low. And so one of the big drivers of prostate cancer is low oxygen. It's this induction of a whole set of transcription factors called HIF 1. A lot of people are not aware that that is a drive. factor, but it was a 2018 Nobel Prize winner from Hopkins, Dr. Semenza, who put together this whole scenario of low oxygen in a cell turns on glucose utilization. So if you don't have enough oxygen around, you run off of glucose. Then when you're running off of glucose, you spit out acid. And that's basically 1922 Otto Warburg, you know, found that all cancers, you take a cancer out, put it in a dish, slice it into little pieces. And every cancer he looked at became acidic when you put it in cell culture.

So every, that's a primary component of all cancer is that you stop utilizing oxygen and you use glucose. and when you use glucose, you spit out acid. You have to tape your mouth shut because even sometimes he barely has his mouth open. Show what you do. Show how little. Well, I don't know because I'm asleep. You're like this.

He says I'm like barely. Yeah, so we got to tape. I'm in a tape. I'm a clencher, Lauren. No, but your lips are slightly open. I've measured with a ruler. You do laying awake at night with a little like ruler next to my mouth. Did we talk about nitric oxide when we were talking before?

Please. Let's speak about it. Yeah. So I think a big component of of that is that. your nasal pharyngeovald is made to produce nitric oxide. And so if you're breathing through your mouth, that's what a mouth breather is, is you're not getting air going through your nose. And then in that part of your sinus that produces nitric oxide is not being released to the rest of your body. And you probably know people are constantly trying to find ways to release nitric oxide in their

body, but while you're asleep, it vasodilates. So all your blood vessels increase in width. You get more blood flow through your whole body for recovery, your brain even, especially. And then that includes your prostate. Is switching on and off that system affects your prostate in a very specific way. So there's an association there, also an association with your microbiome and it's in talking back and forth with your prostate. So, yeah, super important that the mouse tape does a lot of things. This episode is brought to you by Squarespace. Squarespace is the all-in-one website platform designed to help you stand out and succeed

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be early and Polymarket does that for us. Polymarket is now available in the US App Store. You can trade on culture, entertainment, and more all in one place. Download the app and use Code Skinny to get $20 to trade when you make a qualifying $10 deposit. One product that has transformed not only my sleep, but my jawline is mouth tape. I mouth tape every single night. There is not a night that goes by that I miss mouth taping. And the first thing that I notice is I wake up with way more energy. When your nose breathing all night, you get so much more oxygen. It's incredible. And also it supports your tongue posture while you sleep, which sculpts your jawline and makes it stronger. So what I've noticed is better tongue posture, better sleep, more energy in the

morning. I cannot live without it. The other night I actually fell asleep for like two hours without my mouth take and I woke up with a dry mouth. I felt like I was almost like hung over. I can't explain it. I have to have this as my nightly routine. So what I do is after my skincare, I put the skinny confidential mouth tape on. It has a tiny little slit so you can use a straw if you get thirsty in the middle of the night to drink. And then I sleep with it all night. And then in the morning, I missed my face. remove it, and it is the sleep hack of a lifetime. I know anyone who is looking for a better sleep, more energy in the morning, and a more sculpted jawline will love it. You can shop it now at shop skinny confidential.com. That's shop skinny confidential.com. It sounds like one of the great themes that

you have is that you just need to get the body functioning properly in the way that it's designed to function, meaning like it's got to process sugar in the right way, it's got to be able to detox in the right way, he's got to be able to breathe in the right way, you've got to have muscles synthesis in the right way. Like, it sounds like going back to the force analogy, like if you have something in your body that's not functioning the way it was designed to, it's a vulnerability. Is that a correct way of saying? You know what a perfect example that is? It's a great super insight is since I work with so many people that have metastasis, the metastasis often goes to a

place where they know they had dysfunction. So they said, oh, I had my right hip was in pain since I was in my 30s. I was in a car accident or something like that. And so often, that's where the cancer goes. There's Louise Hay is someone who cured her own cancer by a bunch of different things. Everyone should go over. She's fabulous. She's passed now. But, and she did all different kinds of natural modalities. She talks about it in her book. She did juicing. She did the power of positive thinking, a bunch of different things. And she, her belief is similar to what you just said, but she thinks that you hold things where something happened to you. So she believes she got cervical cancer because she was sexually abused. So it went,

it went in her cervix. She believes, like, the right hip is the paternal and the left hip is the maternal. And so if you have problems with one of your parents, she has a whole layout, like, even like she talks about cold sores and why those come of maybe you felt sexually repressed. It's really interesting. It's a whole list, but it's very similar. to what you're saying, that your body is so smart that it knows where to go. Yeah. Right when you're saying that like a million things flash in my head. But I think there's a bunch of animal experiments that kind of really justify what you're

talking about. And they're sometimes hard to bring into the conversation because it has to do with agency. So if you have a mouse in a scenario where it's being stressed, the time but it has no way out. There's no chance of it getting away. And an example of that is whenever it falls asleep, they'll set up an air system where they just puff on it, so it doesn't sleep very well. But it's a stress and you can't get away from it, right? That makes almost every disease model where you do that worse. Yep. Every single one. So agency is really sensitive. That's interesting. So it's, when you say agency, if someone has a stressor in their life,

do you're, what you're saying is it contributes to making the dis-ease worse. Well, you like, the easiest way to think about it for me is like, you, everyone knows when they get so stressed or so upset about something that's feeling they get in their stomach and that acidic taste they get in their mouth. Like, that's, you're obviously causing more harm to yourself by stressing and worrying that much, right? Like, we all know with that feeling. So if you do that consistently, it can't be good for you. Like, it has to, it has to have an effect. And you're using the instinct really, really well there. Like, even you might not know what's going on inside your cell or in your cells or endocrine systems, whatever.

But your description there is exactly point on for what happens to your body. Like when you really over stress, you'll either get epinephrine or cortisol. Cortisol is a glucocorticoid. So you get a giant spike of glucose when you're worried like that. you also secrete hydrochloric acid in your stomach and you know you start digesting your own stomach so all those things are are aligned almost perfectly so michael tried to stress me out this morning he tried real yeah he tried real hard a bit you did so i'm going to say that i'm protecting my cortisol and my epithrin and i'm going to take a walk and you can sit and talk to yourself i didn't think

i was stressing you all but you were stressing me out so i'm i'm going to protect my That's thanks to Dr. John. I'll point it. I do, but here's the other thing though. It's like I do like the the stress response is designed to indicate some kind of danger or some kind of threat. So I think it's useful, but not for prolonged periods of time. Yeah. Right. Like you don't want to be an animal in the woods and get that and be like, everything's fine and then have a tiger come out and bite your head off.

Yeah. Right. Like you should feel a little bit of stress once in a while. It's super interesting because it's the disconnect that doesn't make sense is if you get a giant, um, you should be a giant, um, you should be a big. burst of epinephrine where, you know, it changes all the blood flow from your gut to your muscles and your skin. And if it's high enough, you start sweating, that's your coolant system. So if then you don't run, you're like, oh, that's a complete disconnect between, you know, the physiology you just induced and what is supposed to relate to. You're supposed to run full tilt

until you're out of breath. The problem is people get these responses now when they're not actually in physical danger like we used to be. And then they just carry that stress, like, you know, sitting in an office or the desk or whatever. Let's get every person on the planet to get these broccoli sprouts because they're so amazing. You have said that most broccoli supplements are garbage. This one is not. It is the best of the best.

I take it. I love it. I also eat broccoli sprouts. If you don't get this supplement, go buy broccoli sprouts from a local farmer's market. But for those who want the broccoli, the best. Yeah. Can we give him a code? Yeah, for sure.

It's Mara, M-A-R-A-Labs. Okay. ...com, C-O-M-F-S-S-Sh-SK-E-M-S-Sysh-Skyny. Thank you. That's 25% off for a week. Oh, that's a good offer. And then I think after a week it goes back to 15, so still a good deal. Mara-Dashlabs.com slash skinny.

Go get the broccoli supplement, the broccoli sprout supplement. They also have one for kids. I have my whole family on this. I have sent it out to everyone I know. I'm really passionate about this. That's why I invited Dr. John back on the show. Before you go, there's one thing I think it would be helpful for you to touch on. If somebody has a family member or they themselves have gotten a diagnosis like we've been talking about,

from a mental perspective, having you having been through it with your wife and working with so many people, what is something you would tell those individuals or their family in order to kind of manage that mental stress? Yeah, it's really interesting. We do something with people often when you try to, boil down a large list of possible stressors down to one is we'll ask the question, pull out a piece of paper and write down the reason why if you were going to get cancer, why would you? And your instinct will tell you what is the first thing that you're supposed to do. And so people come back with, you know, it's this person at work. You know, I just

I can't. So whatever it is, try to find your agency in changing that. And if you do that and you feel better, and then there's another stress that's out there, do it again. Write it down. Track it. Do, you know, give yourself agency. You know, those mice, if you gave them a way out from that puffer, none of it affects them. That's a beautiful message, what you just said. That is a great tip. And it sounds also like when you get this information and these diagnoses, it's also maybe not a bad idea to pause and take a beat and gather information as opposed to just like getting in the cycle of go, go, go, go fast, fast, fast. Yeah, because most people don't realize, like for colon cancer, it takes 10 years. And so it's going to be fine if you take a couple of weeks and try to talk to somebody as part of your first couple of steps is talk to an oncologist. just ask if, you know, he's open to doing natural things as well and changing lifestyle things.

That's another question you can ask them. I just, I love when you can give someone agency. Like, they're not frantically freaking out. And, you know, that's actually driving it worse. And you also want to, you know, give people hope that there's people in your scenario that have done perfectly well. Dr. John, if you guys like this episode, we will leave the other episode with Dr. John that we did in the past below in the show notes. Thank you for coming on, mara-dashlabs.com slash skinny. Thank you. Thank you, Dr. John.

Yeah, thank you so much. This is awesome.