Throughline - The Man Who Cured Aging

Episode Date: January 25, 2024

In 1899, Elie Metchnikoff woke up in Paris to learn that he had defeated old age. At least, that's what the newspaper headlines said. Before long he was inundated with mail from people begging him to help them live forever. The only problem? He didn't know how to do it. At the time, Metchnikoff was one of the world's most famous scientists. And he believed aging was a disease he could cure. He dedicated his life to that quest, spending his days interviewing centenarians, pulling gray hair out of colleagues and old dogs, and boiling strawberries — all in the pursuit of eternal youth. If you've ever had yogurt for breakfast, you likely have Metchnikoff to thank.Today on the show: Elie Metchnikoff's quest, his life — and his deathLearn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

Support for this podcast and the following message come from Autograph Collection Hotels, with over 300 independent hotels around the world, each exactly like nothing else. Autograph Collection is part of the Marriott Bonvoy portfolio of hotel brands. Find the unforgettable at AutographCollection.com. Around 200 BC, China's first emperor, Qin Shi Huang, feared death so badly that he sent an alchemist on voyages across the sea to search for a magic elixir that would give him immortality. After the alchemist disappeared at sea, the legend says the emperor took things into his own hands and died after drinking what he thought was a cure. Around 200 years later, another legend was born.

A holy grail that was thought to hold life-restoring powers for anyone who drank from it. There was the Philosopher's Stone, the Fountain of Youth, and then, in late December of 1899, a scientist named Eli Metchnikoff woke up in Paris to learn that he had done it. He had found the secret to eternal life. The French morning newspaper Le Matin carried a huge headline in large block letters all across the front page. And it said,

Vive la vie, long live life. Underneath that headline, it said things like L'Elixir de l'Eternelle Jeunesse The Elixir of Eternal Youth L'Institut des Miracles, the Institute of Miracles, la Vieillesse Vaincue,

Old Age Defeated. None of us should despair to see the year 2000. We'll reach the age of the Patriarchs and Monsieur Meshnikov will be damned only by heirs of fortunes. Eli Meshnikov had captured the world's attention. For millennia, people had tried to evade death, seeking cures in things like mercury, gold, powders, liquids. But now, they had a new tool. Science.

And it was miraculous. There were new vaccines. X-rays had just been invented. You could now see what had once been invisible. And Metchnikov had helped to make that happen. He was very famous. He was one of the most famous scientists in the world. Eli Metchnikoff was hardcore. The man drank cholera in the name of science. He injected himself with disease and he tested the body's power and its limits. Later in his career, his work on the immune system would win him a Nobel Prize. When the world was sick, Eli Medchnikov tried to cure it. And he made sure people knew. He loved the journalists. He never turned them away.

And they loved him even more than he loved them. And they followed him around and they took down his every word. And his message was clear. He thought that a solution to everything was science. So, of course, science was going to solve aging as well. Aging is a disease that should be treated like any other. No one had studied aging scientifically before. And here was this famous scientist saying he wanted to take it on.

But Metchnikov didn't just want to study aging. He wanted to cure it. This became for him like a new mission. Science alone can lead suffering humanity into the right path. Free the world from this terrible affliction. And the world ate it up. Entire sacks of letters that piled up in the mailroom was stuffed with letters from people who didn't want to die.

Nobody likes to die. Nobody likes to see their friends and family die. So we want to extend the lifespan as much as possible. People nowadays want to remain ageless. We can delay aging. It's one of the foundational questions in science. We can stop aging. How long can we live? We keep searching. What is it exactly we're looking for? I don't know what I want to do. Living to 200? Are we looking to living to, you know, 95 with our senses and being active and in control. I think the most important thing to me is maintaining my mobility.

I would love to like renovate a house. I think I want to travel more. Traveling as much as I can. More time to myself. We all know that winter is coming for us. I think I have about 20, 25 years left. The question is when and can we push it out as much as possible? People have been talking about it for thousands of years.

It's not a new question, it's an old question. Since the beginning of human civilization, people have been obsessed with staying young, even living forever. Today, that obsession is tied up with media, medicine, and money. So I got this straw on Amazon, and it literally is the best. We spend billions of dollars on anti-aging products. It doesn't cause wrinkles. You can easily drink out from the top of it. We spend billions of dollars on anti-aging products. It doesn't cause wrinkles. You can easily drink out from the top of it.

We're told to look younger. The top 10 celebrities who have aged badly. We question whether older people are fit to lead. Poll after poll has shown that many voters are worried about the age of the two likely nominees. But what if these are the wrong questions? Is aging something we even need to cure? And what does it mean if we can't? I'm Ramteen Arablui. I'm Randa Abdel-Fattah. On this episode of ThruLine, we're not going to answer the question of aging, but we are going to tell you the story

of someone who tried. Coming up, our producer Devin Katiyama tells the story of Eli things in other currencies. Send, spend, or receive money internationally, and always get the real-time mid-market exchange rate with no hidden fees. Download the WISE app today or visit wise.com. T's and C's apply. Support for this podcast and the following message come from the NPR Wine Club, which has generated over $1.75 million to support NPR programming. Whether buying a few bottles or joining the club, you can learn more at nprwineclub.org slash podcast. Must be 21 or older to purchase.

Part 1. This Love of Life The country is neither beautiful nor rich. Part 1. This Love of Life. The country is neither beautiful nor rich. Steps, helix, covered with low grasses and wild warm wood. A poor village, meager vegetation, no river. The whole impression is a melancholy one. In the middle of the 19th century, Ilya Ivanovich and his wife and children left St. Petersburg, Russia, for the countryside.

But what boundless space, what soft, silver-gray color rain, and in the mornings and evenings, what fresh, cool air. It was here, on a little slice of land outside the main village, that they would welcome their fifth child into the world. Though they wished to have no more children, one more child was born on the 16th May, 1845.

Eli Mechnikoff. These descriptions of Eli Mechnikoff's early life are from the biography his wife, Olga, wrote about him. Fair in slander, with silky hair, and a diaphanous pink and white complexion. He had small gray-blue eyes, full of kindliness and sparkle. He had a few brothers and sisters, and of all of them he was probably the most curious. He was so restless that he went by the name of Quicksilver. He always wished to see everything, to know everything and found his way everywhere. As a kid he was always chasing bugs and you know looking at what bugs do. He could only be kept quiet when his curiosity was awakened by the observation of some natural object, such as an insect or a butterfly.

Then he would invite all of his siblings and cousins for a lecture in natural history. And he would actually pay them out of his pocket money to come and listen to his lectures. This is Lina Zeldovich. She's currently a science and medical journalist in New York City, but she grew up in the former Soviet Union, where Eli Metchnikoff was a household name. So I learned that name at a very young age.

She remembers hearing about his famous discoveries, the same way you might have learned about Albert Einstein's E equals MC squared. He was like, you know, a cherished name, a big name. A couple of research institutions were named after him. We definitely knew about him growing up. Metchnikoff was born in a time and place when medicine was only just starting to modernize. The human body wasn't really understood, and diseases like cholera and typhoid were really scary. Many doctors still believed in bloodletting and would actually treat patients with toxic

substances like mercury and lead. So medical care itself was basically synonymous with suffering. From a very young age, I think he had this desire to alleviate human suffering, and that's how he sort of found his way into biological research. So Metchnikoff grows up to become a zoologist, and he couldn't have picked a better time because when he was just 14 years old, a new theory rocked the scientific world. Charles Darwin's theory of evolution. The main goal at the time of many scientists and of him as well was to test Darwin's idea that all life on earth came from the same common ancestor. And he dedicated his early career to researching that theory.

When he was in his late 30s, he traveled to Italy, to the island of Sicily, to study marine animals. And he was studying the larva of starfish. This is Luba Vukonsky. She's a science writer at the Weizmann Institute of Science in Israel. And I've written a book called Immunity, how Eli Metchnikoff changed the course of modern medicine. This trip to Sicily would change everything for Metchnikoff. He and his wife were staying by the seaside in a cottage overlooking the bright blue Messina Strait. The strait was home to all sorts of marine creatures. And while his wife went out to explore Sicily,

Metchnikoff would spend long days holed up in the cottage, staring at jars filled with seawater and tiny organisms. One day, he had his eye pressed up against his microscope, peering inside these minuscule starfish larvae. And in the larvae, he saw mobile cells. These were cells that wandered inside the larvae, gobbling up food and other particles. Meshnikov had seen these cells in action before,

but that day, watching them go about their business, it struck him. He came up with the idea that maybe this is a defensive force of the organism. Sensing that my hunch concealed something particularly interesting, I became so excited that I began striding up and down the room. He performed an experiment. It's a very famous experiment in immunology where he inserted thorns into these larvae. If the cells attacked the thorn as a foreign invader, his theory would be correct.

And he saw that the cells indeed ganged up on the thorns. This was for him evidence of his theory that they wereed up on the thorns. This was for him evidence of his theory that they were there to protect the larva. Watching this unfold through his microscope, his mind was blown. In fact, this was the first material evidence of inner healing forces in science. The invisible had become visible. Metchnikoff wasn't the first person to observe this healing force, but he was the first person to define it as an immune response.

This was the work that would later earn him a Nobel Prize. The idea that the body has inner powers that can be studied and enhanced and understood. I mean, that's enormous. It just turned everything around. Around the turn of the century, while Metchnikoff was consumed by his work on immunity, another question started to nag at him. He was living in Paris and working at the Pasteur Institute. The Pasteur Institute was home to the miracle makers of the day, scientists who

were researching vaccination or figuring out what caused plague. He was in his mid-50s. He started having kidney trouble and he began to worry about his own aging. And he also began to fear death. Our strong will to live runs counter to the infirmities of old age and the shortness of life. That's greatest disharmony of human nature. Life expectancy at the time was around the mid-40s, so he must have had a growing sense of his own mortality. But he wasn't just concerned about himself.

In his mind, aging was one of the greatest problems facing humankind. The fact that we all grow older, and that aging meant sickness until death. And he was appalled to discover how little was known about aging and that there was no systematic study of aging. There were textbooks about diseases of old age, but not about old age itself. And Metchnikoff comes up with this theory, an idea that would stay with him throughout his entire life. His hope was that if people live long enough, they will develop this death instinct. The death instinct. This instinct must be accompanied by marvelous sensations,

better than any other we are capable of experiencing. Death instinct would mean that people would be happy to die after living a long and healthy life. Perhaps the anxious search for the purpose of human life is nothing but a vague yearning for this anticipation of natural death. He went around looking for this death instinct. He became so obsessed with figuring out how older people felt as they approached death that he would literally chase the elderly down. Centenarians made it into the newspapers.

So whenever he would see an article about an old person, he rushed to meet them and he wanted to ask them, you know, about if they wanted to die. So this is late 19th century. We're going through a transformation from the agrarian economic system to the industrial economic system. This is Carol Haber.

She's a professor and Dean Emerita of Tulane University in the School of Liberal Arts. I was trained as a medical and social historian, and I focused largely on the history of aging. Carol says she doesn't think there was ever a time when old age was seen as something wonderful, that everyone respected. But around the time Metchnikoff turned his attention to aging,

there was a cultural shift happening in how people viewed it. If you look at the late 19th century, the image of the old person is hunched over with a cane, sitting in a rocking chair. It's pretty negative. At that time, the Industrial Revolution was changing how families lived and worked. And in this work revolution, the elderly were getting left behind. You had the feeling that there wasn't this basis of support. And in this work revolution, the elderly were getting left behind. You had the feeling that there wasn't this basis of support and that old people were going to end up in what they called the industrial scrap heap.

They couldn't keep up. They couldn't learn new skills. And so they were going to become obsolescent. Western society's view, whether it was true or not, was that the elderly weren't compatible with the increasingly fast-paced world. Caring for the elderly came to be seen as a burden. Many elderly people ended up living the rest of their days in a hospital. And that's exactly where Metchnikoff went to find them.

He went to this large French hospital, La Salpêtrière. La Salpêtrière was an infamous hospital in Paris. It had long doubled as a psychiatric ward and a home for the elderly. And most of them were poor because, you know, obviously a more wealthy elderly wouldn't make it there. For a lot of Parisians, it was a dark, distant presence looming over the city. Inside its imposing brick walls was a massive, sprawling complex that for centuries had been a place of squalor and suffering. A famous French neurologist referred to it as

Le Versailles de la Douleur. The Versailles of pain. It probably must have been quite a sad place, where all these people were brought to die and there was not much that could really be done for them. But it was the perfect laboratory for Mechnikov. He went around asking them what they wanted, and he was hoping to find the death instinct. And he was really disappointed because even the sick old people, they didn't want to die. They wanted to get better.

I discovered that one and all felt as if they were continually being threatened by death, as if they were convicts awaiting the day of execution. At the Salpêtrière, the great ambition of women of 80 is to live to 100, and the desire to live is almost universal. Even in a miserable place like Salpêtrière, people wanted to live longer. What is this love of life that makes death so terrible? He developed a whole philosophy that there was this big disharmony in the world, in nature, between the shortness of human life and people's desire to live.

Metchnikoff came to believe that aging was a disease, and he was sure that science could cure it. He envisioned a utopic future where medicine could prolong life up to 150 years. At that age, he thought, the death instinct would finally appear. So he went all in. This became for him like his new mission to free the world from this terrible affliction. Coming up, Metchnikov heads back to the lab with a new mission

to extend human life to 150 years. Hello, this is Nancy Smith, and I'm in Kiel, Germany. You're listening to ThruLine from NPR. It's a great show. I love it. Keep up the good work. We just want to take a moment to shout out our ThruLine Plus subscribers. Thank you so much for your support. If you don't already know, subscribing to ThruLine Plus means you get to listen to our show without any sponsor breaks. And you also get access to special bonus episodes where we take you behind the scenes, introduce you to our amazing producers, and tell you about how we make the show.

To get these awesome benefits and support our work here at NPR, head over to plus.npr.org slash throughline. Support for NPR and the following message come from Carnegie Corporation of New York, working to reduce political polarization through philanthropic support for education, democracy, and peace. More information at carnegie.org. Part 2. Trusting His Gut. In his 20s, Eli Metchnikoff had been visited by death. His first wife died of tuberculosis. It's a disease that kills you slowly.

You can basically watch your loved one wither away. Day after day, month after month. They travel to places with better climate, milder winters, sunnier places, and nothing helped, and she eventually died. This sent Metchnikoff into a deep depression. And then, a decade later, he went through it again. His second wife contracted typhoid fever, and it looked like she could die, and so he inoculated himself with some kind of a tick-borne disease,

thinking that they will die together. But neither one of them died. And this changed everything for Metchnikov. After his recovery, he had a renaissance of vital intensity. The life instinct developed in him in a high degree. His health became flourishing, his energy and power for work greater than ever, and the pessimism of his youth began to pale before the optimistic dawn of his maturity. Fast forward a couple of decades. It's the early 1900s.

The now famous Metchenkov set out to pioneer the study of aging and cure it. He wants people to be able to live happy and healthy until they're ready to die. The purpose of human existence lies in going through a normal cycle of life, leading to a loss of the life instinct and a painless old age, bringing about a reconciliation with death.

By now, he's a superstar at the Pasteur Institute, which was one of the most prestigious science facilities in the world at the time. It's sort of a scientist's dream. He has lab assistants, facilities, all the resources he could imagine at his fingertips. And he gets to work. His lab gradually filled up with old animals of all sorts. There are mice and rats and geese and cats and dogs.

There's this 87-year-old turtle and a 70-year-old parrot. Meshinkov was very happy that he was still interested in females. And that's just the beginning. He starts pulling out hair from an old Great Dane, from a co-worker, and then from his own head to figure out why it's turning gray. And remember, he's a renowned immunologist with kind of a savior complex. So he's also spreading the gospel to everyone he knows. When he rode on public transportation, he would tell people how they should be careful about microbes.

He boiled everything he ate, even strawberries and even peeled bananas. He thought that the skin probably didn't protect them well enough. And when he invited guests to restaurants, he asked to bring a burner and he sterilized the utensils. Okay, so maybe he's not like the most fun guy to have around, but this is the beginning of the science of aging, of gerontology, which by the way was a term that Metchnikoff coined in 1903. And science is all about making mistakes, so you can find that one thing that works. And as he's conducting all these experiments, he zeroes in on this one idea, that the body was being poisoned.

He thought that the root of aging, that it all started in the intestines. Specifically, the large intestine. The large intestine must be regarded as one of the organs possessed by man and yet harmful to his health and his life. The presence of large intestine in the human body is the cause of a series of misfortunes. The idea that something bad was happening in the intestines is one that dates back thousands of years, so this wasn't necessarily a new idea. But in the late 19th century, it was making a comeback because science was making new links to germs and disease.

At the time, the human intestine was viewed as accessible of all sorts of toxins. I guess the proof that all the scientists had was, you know, hey, just look what comes out of your rear end. Any more questions? So Meshinkov thought that in the intestines, there are microbes that cause rotting, and that the rotting is what really causes the deterioration of aging. The big question became how to fight that. Then one day, he has a breakthrough. He learned that in Bulgaria, there is this entire population of centenarians in the mountains. Remember, Metchikov is obsessed with centenarians.

And there were newspaper articles backing up this idea that people in this region of Bulgaria were living a long time. And so he had to know. Why? Yogurt. Yogurt. They ate lots of yogurt. Metchnikov had to tell everyone. It's 1904, Paris. A crowded lecture hall at the Society of French Agriculturalists. The famous Eli Metchnikoff is the guest speaker.

The lecture was called Old Age. And he starts by getting up there and rattling off some pretty dark ideas. He was saying how in Europe, old people are miserable. Their lives often become very difficult. Unable to fulfill any useful role in the family or in the community, old people are considered a very heavy burden. He claimed they were more likely to commit suicide or be murdered. One is shocked by the quantity of murders committed against the elderly, notably against elderly women. He also repeated, without evidence, by the way, that some cultures

killed and ate their women. Because they're useless. And he said that people there say that all dogs can at least capture seals and all women can't even do that. He was painting a very sort of gruesome picture of old age. Metchnikoff is straddling the line between serious science and being a salesman because he's still trying to sell the world on science. So he's playing to his audience, stoking the fears of aging that are growing at the time and then saying, hey, don't worry, science has the solution. He brought an old dog and a parrot. The dog was 17 and he looked very old and undecorated.

And the parrot, who was 70, looked much younger than the dog. And then Metchnikoff lays down his science. Birds do not have such large intestines as mammals. They don't store as many microbes. And he says, if we can find a way to prolong that decay in our intestines, then maybe we can prolong it in the rest of our bodies. And then he says, maybe there's a solution, because, you know, in Bulgaria, people live that long.

It is interesting to point out that this microbe is found in sour milk consumed in large quantities by Bulgarians in a region renowned for the longevity of its inhabitants. He connected all these dots together. We age because in the intestines there is rotting. And lactic acid that is produced in sour milk can stop this rotting by killing the bacteria that cause the rotting. And there you have proof. All over the world, you know, newspapers started running stories. The Chicago Daily Tribune. Sour milk is a lexer, secret of long life discovered by Professor Meshnikov. And there was no turning back.

I mean, this started a real mania, yogurt mania. The London Telegraph, The Washington Post. People who wish to live to 100 breakfast off of yogurt exclusively. That one lecture, Luba says, started a global yogurt trend that still exists today. I think it's rare to trace the beginning of an industry to a single event. But in this case, I can pretty much say that the yogurt industry started with that lecture. Much later, we'd find out that yogurt was probably not the only reason people in that region of Bulgaria lived so long. But it didn't really matter. Pharmacies started stocking yogurt. Doctors recommended it to

patients. People used it as a disinfectant or preparation for surgery, even to treat some diseases. This stuff was all over the place. There were ads, this cafe on one of the Parisian boulevards advertised Bulgarian curdled milk. The yogurt craze kind of, you know, grew and grew. I saw pictures of Danone, which I think in the States is called Danone. Yeah, Danone yogurt. I mean, I don't even know how many different brands of yogurt we have today, but Danone is still there. Even breakfast cereal pioneer John Harvey Kellogg reached out to Metchnikoff. His face was everywhere.

They sold cups of yogurt and it said, recommended by Professor Metchnikoff and the medical profession. It was totally, it got out of hand, completely. There was all this hype and all this hoopla about it that he had no control over. This wasn't exactly what Metchnikov had wanted.

Throughout his career, he was always arguing over how the media took his research and ran with it or twisted his words. He gave caveats to his work. He called his ideas theories. He tried sort of to present the facts and to separate it from the hype, but it was just way too late. The good thing about yogurt was that it was harmless, because so many cures for aging were terrible and dangerous and lethal. And yogurt was cheap and it was safe and easily available.

So it was irresistible. Metchnikoff was a scientist, but he was also a showman. Maybe yogurt wasn't a magic elixir, but science would still find the answers. Coming up, Metchnikov returns to Russia to face one of his biggest critics. He's 63 years old, and he doesn't know it yet, but he's running out of time. Hello world, I'm Giles Smith from Zurich in Switzerland and you are listening to ThruLine from NPR Part 3 Winter is coming From NPO. Part 3. Winter is coming.

It was at dawn that we reached the little railway station where a carriage had come to meet us. On a cloudy May morning in 1909, Eli Metchnikoff, bowtie and gray coat, and his wife Olga, white blouse, straw hat, descend from an overnight train. We were excited by the sight of the Russian country. Cool meadows, forest, fields, all such simple landscapes that we had not seen for so long. And we were also greatly moved at the idea of meeting Tolstoy. Metchnikov has returned to Russia, where he was born, to visit the writer and philosopher Leo Tolstoy.

So he was looking to sort of to solve the riddle of aging on all levels. He was looking for partners in this quest. I had long wanted to get to know Tolstoy closer, learning in person what he really thought about universal issues that had fascinated me since my youth, especially the basis of morality, the meaning of life, and the inevitability of its end. He admired so much Tolstoy's writing about the fear of death, which are really masterful. A man can be master of nothing, while ever he fears death.

And the man that fears not death possesses everything. Without suffering, a man would know not his limits. So he thought that Tolstoy must know some secret that I don't. This wasn't just some random meeting. Although the two had never met, their work had been in conversation for years. Tolstoy was critical of Metchnikoff's work and threw shade on science in general. Scientists can tell useful knowledge from useless. They study such topics as the sexual organs of the amoeba only because this allows them to live like lords. And Metchnikov had written responses about Tolstoy, warning of the dangers of discarding science and embracing just spirituality.

In certain cases, his teaching had caused young researchers to drop science, burn their dissertations, and join communes to start a new life. Now it's time to talk face-to-face. Metchnikov had minds. Now he needed hearts. At Tolstoy's estate, Metchnikoff notes its simplicity. The furniture functional but old, any airs of luxury done away with. Tolstoy, 80, with a white flowing beard and white shirt, bounces down the stairs full of energy.

The reporter called it a meeting of two monarchs of universal literature and science. The two spend the day together, debating science versus religion. Debating as they ride in a carriage. Debating after listening to Piano Works by Chopin. Debating After Listening to Piano Works by Chopin Debating Over Tea I highly value genuine science, one that is interested in man, his fate, and happiness. Any ideal that may be capable of uniting mankind in some religion or the future must be based on scientific principles.

For Metchnikov, science and reasoning always key. For Tolstoy, morals above all. If we are going to submit everything to reasoning, we can arrive at the most absurd nonsense. I dare say, in that case, it would be possible to justify cannibalism. Progress doesn't necessarily have to be based on people's love for one another. When it came to Metchnikoff's current work on aging... The trouble is not that our life is too short, but that we live badly, contrary to our own conscience. So the only thing on which they agreed was yogurt, because Tolstoy turned out to love yogurt.

But other than that, it was pretty much a disaster, the meeting. Mitrikov very candidly, very honestly wrote about this himself afterwards. Tolstoy noted that at the end of the day, our worldviews coincide, but with this difference. He takes a spiritual perspective and I take a material one. Meshikov was much more spiritual than Tolstoy gave him credit for. He did try, I think, to understand human psychology. And I think he thought that somehow together with Tolstoy, he could get closer to cracking this riddle of, you know, what really happens in the human psyche, in the human mind,

how, you know, we feel like that, how we feel when we age, why, you know, this fear of death. And of course, it just, you know, totally crashed. You know, the meeting didn't work at all. And Tolstoy and Menchikov's dispute of science versus religion fit into this larger European debate at the time over how to view and improve life. At the turn of the 20th century, this was a very dominant dichotomy between pessimism and optimism. Sort of your belief about the world. Is the world getting better? For Tolstoy, the answer was no. So morality, love, and faith in the here and now was the most important.

But Metchnikoff, an optimist, saw things differently. In headlines, the New York Times had crowned him the apostle of optimism. But of course, he continued to age. In some of the Russian newspapers, he was bragging about how good he felt. He was saying that this is working. Look, you know, I'm eating yogurt three times a day.

I believe, you know, it's doing me a lot of good. And look how vigorous I am. Metchnikoff's outwardly positive, science will save us all outlook was getting harder to maintain. In 1914, as his research continued, the headlines made a dark world impossible to ignore. Assassin's bullet strikes down Archduke Ferdinand of Austria. Germany declares war on Russia. England declares war on Germany. 25,000 dead and wounded.

Peace refused by France. War declared. All Europe in turmoil. What really killed him was World War I. He was such a believer in rational thought in science. He thought that there will be no more wars, that the world had learned from that. And he was devastated when war broke out and all science stopped at the Pasteur Institute.

Over 100 people at the Pasteur Institute get recruited to the war effort. His wife describes it like how overnight he turned into an old man. He could not bear the idea, now a terrible reality, that these brilliant young lives should be sacrificed. War, she wrote, became a dark, sinister background to his daily life. And even though he had tried to convince Tolstoy that science had the answers to everything, that now looked empty in the face of a world war. He'd always thought his purpose in life was to help people reach their death instinct, right? To live longer and live healthier until they felt ready to go.

The idea that humans would willfully create so much death crushed him. The contrast between his aspiration and the cruel reality had been to him a blow, which his sensitive and suffering heart was not fit to bear. In 1916, so this was already what, like more than a year after the war started, his health began to deteriorate and he developed heart disease, heart failure. In terms of the fear of death, he kept coming back to this and he kept saying that I have conquered my fear of death, I've conquered it. And the truth is that you end up feeling the exact opposite, because had it been true, I don't think he would have had the need to repeat it so many times.

So it was obviously something that he was still struggling with, I think, till the end of his life. Let all those who expected me to live 100 years or longer forgive me my premature death so he died from a heart attack and the moments before he died, he asked his assistant to carefully look into his intestines and see what's there once he was gone. He died in 1916 at 71, not even halfway to the 150 that he thought people should live. Many people were all over the world were disappointed.

There were headlines saying, you know, what have you done? We believe, you know, because even despite all the skepticism, I think people wanted to believe that maybe it's true. Maybe he has found a recipe, a cure. What's the secret to a good life? I don't know what I want to do. I don't know what I want to do. I want to have a baby. Aging is not inevitable anymore. Companies are betting big money on it.

If we can slow aging enough, then we will be happy. If you're concerned about preventing or minimizing the signs of aging, then this video is for you. These are the nine anti-aging foods. Drugs that can slow down the aging process. You know, we should all be so lucky to age and grow old and get to experience this part of life. When you try and imagine it when you're younger, you think you may not want to be there because you get these images in your head of being bent over, you know, using these walkers and you don't want that to happen to you. But once you get out here, you know, you look around and you go, hey, nothing's different. I'm just older. This is Jay Olshansky, professor of public health at the University of Illinois at Chicago.

He's one of the people today following in Eli Metchnikoff's footsteps. Been working in the field of aging for almost 40 years. Trying to figure out why people live as long as we do and how to make that last even longer. In the year 2000, a few years after Eli Metchnikoff would have turned 150, Jay made a bet. Basically, the bet was all about whether or not anyone alive in the year 2000 would be alive in the year 2150. Could science keep someone alive until they're 150 years old? My good friend thought that it was possible, and I said, no, it's not possible.

The process of living itself leads to the degradation, the continuous degradation that ultimately leads to the demise of mind or body. And we have components of the body that don't replicate. Muscle fibers, brain neurons, parts of our bodies that power on life and degrade as you age. Those are our Achilles heels. So we can't get these bodies to last that long

unless we turn the engine of life off. And when you turn the engine of life off, you're dead. But Jay believes in the promise of science. It's taken us so far already. People live much longer than they did in Metchnikoff's day. Jay thinks science will take us even farther, so that we can live healthier, longer. Do I know which one of these interventions is going to succeed? No, I don't know. All we need is one that does. The human desire to beat aging began way before Metchnikoff

and will likely last way after Jay. Nobody likes to die. So we want to extend the lifespan as much as possible and health span as much as possible. Kind of just how Metchnikov envisioned. And with that goal, we keep searching. Winter will come for me. It will come for all of us.

The question is when and what can we do to do what's the most important thing in my view, which is to enjoy life while we're here. We only get to go through this journey once. And, you know, for humans, it's about 29 to 30,000 days. That's all we get. It, you know, varies, but that's it. 29 to 30,000 days. That's it. Though in some ways, some of us get more than that. Eli Metchnikoff wasn't able to beat aging, but he's still with us. In fridges and on breakfast tables. Everywhere. everywhere. That's it for this week's show.

I'm Randabdit Fattah. I'm Ramteen Arablui. And you've been listening to ThruLine from NPR. This episode was produced by me. And me. And. Lawrence Wu. Julie Kane. Anya Steinberg. Casey Min me. And me. And. Lawrence Wu. Julie Kane. Anya Steinberg.

Casey Miner. Christina Kim. Devin Katayama. Peter Balanon Rosen. Thomas Liu. Irene Noguchi. Thanks to Leslie Kossoff, Susan Evans, Sam Evans, Carol Hacker, Stefan Hubinoff, and Anandita Bolero. Also thanks to Sasha Solieva, Zahar Kinsersky,

Artem Kuznitsov, Peter Balanon-Rosen, Anya Steinberg, Thomas Liu, and Laurent Lasablier for their voiceover work. Fact-checking for this episode was done by Kevin Vogel. This episode was mixed by Maggie Luthar. Thanks to Johannes Dergi, Yves Chapin, Colin Campbell, and Anya Grunman. Music was composed by Ramtin and his band, Drop

Electric, which includes Anya Mizani, Naveed Marvi, Sho Fujiwara, and finally, if you have an idea or like something you heard on the show, please write us at throughline atine at NPR.org. Thanks for listening. Everyone at work were an expert communicator. Inbox numbers would drop, customer satisfaction scores would rise, and everyone would be more productive.

That's what happens when you give Grammarly to your entire team. Grammarly is a secure AI writing partner that understands your business and can transform it through better communication. Join 70,000 teams who trust Grammarly with their words and their data. Learn more at Grammarly.com. Grammarly. Easier said, done.