Weird Medicine: The Podcast - 504 - When S#!& Becomes Valuable...
Episode Date: May 8, 2022Dr Steve discusses (despite allergy-associated derangement of his vocal cords): New Fecal Transplantation Data Chemical Depilitation on the Nether Regions (don't) Pilonidal Cysts, treatment and pr...evention More Dollywood history and more Join us for live recordings on https://www.youtube.com/c/DoctorSteve202 YouTube every Wednesday at around 3:30pm! Please visit: stuff.doctorsteve.com (for all your online shopping needs!) simplyherbals.net (now with CBD nasal spray!) Cameo.com/weirdmedicine (Book your old pal right now while he’s still cheap!) noom.doctorsteve.com (the link still works! Lose weight now before swimsuit season!) chef.doctorsteve.com (green chef, the best of all the meal kits we've tried!) CHECK US OUT ON PATREON! ALL NEW CONTENT! Robert Kelly, Mark Normand, mystery guests! Stuff you will never hear on the main show ;-) Learn more about your ad choices. Visit podcastchoices.com/adchoices
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                                        Why was the sand wet?
                                         
                                        Because the seaweed.
                                         
                                        Which baseball team always has a sense of deja vu?
                                         
                                        The New York haven't we metz?
                                         
                                        What do you call a cactus that's really, really sure?
                                         
                                        sharp.
                                         
                                        Pricotious.
                                         
                                        Ow.
                                         
    
                                        If you just read the bio for Dr. Steve,
                                         
                                        host of weird medicine on Sirius XM103,
                                         
                                        and made popular by two really comedy shows,
                                         
                                        Opie and Anthony and Ron and Fez,
                                         
                                        you would have thought that this guy was a bit of, you know, a clown.
                                         
                                        Why can't you give me the rest?
                                         
                                        I suspect that I'm entitled to!
                                         
                                        I've got diphtheria crushing my esophagus.
                                         
    
                                        I've got Tobolivide stripping from my nose.
                                         
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                                        All my ailments, the health equivalent of citizen cane.
                                         
    
                                        And if I don't get it now in the tablet,
                                         
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                                        I want a requiem for my disease.
                                         
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                                        From the world famous Cardiff Electric Network Studios.
                                         
                                        It's weird medicine, the first and still only uncensored medical show in the history of broadcast radio.
                                         
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                                        I'm Dr. Steve.
                                         
    
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                                        rather than vice versa, that's a good show.
                                         
                                        Tacey isn't shy.
                                         
                                        in that regard.
                                         
                                        Anyway, all right.
                                         
                                        Listen, I'm very sorry that this show is so late getting out.
                                         
                                        I had just a shite week at work,
                                         
                                        and I'm going to be having shite weeks at work
                                         
                                        for the next probably one to two months.
                                         
    
                                        And then come October as I step down for my system roll
                                         
                                        and go back to what I really love doing,
                                         
                                        which is seeing patients and teaching,
                                         
                                        things should get a little bit better.
                                         
                                        better. And I'm hoping I'll be able to put a little more focus on the show and all those
                                         
                                        kinds of things as well. So hopefully the quality will improve on the show. And that's it.
                                         
                                        So let's get into it. Someone on Twitter sent me an article that I thought was really fascinating
                                         
                                        because we've been talking about mind-gut access on the show for a long time and also fecal
                                         
    
                                        transplantation and then now here you go here's an article that's titled fecal transplants
                                         
                                        reverse signs of aging in brain gut and eyes of mice so this is a murine study meaning that is
                                         
                                        you know a mouse derived data but this is where this stuff starts we seem to be totally fine
                                         
                                        doing things to mice that we wouldn't do to each other and then but if it works and on the
                                         
                                        mice, then we are, we'll take it to the next level, maybe do a primate study or a larger,
                                         
                                        you know, a pig study.
                                         
                                        Pigs are a little closer to us than mice are.
                                         
                                        And if it works in the pigs, then they might do a primate study, and then if that works,
                                         
    
                                        it may do human trials.
                                         
                                        But here's that article.
                                         
                                        It says, and this is from new atlas.com.
                                         
                                        The connection between gut bacteria and human health continues to be illuminated in all kinds of ways,
                                         
                                        among the more fascinating is the way these microbes might influence different aspects of the aging process.
                                         
                                        So whenever I see anti-aging stuff, I'm always skeptical up front just because there have been so many scams in the past.
                                         
                                        But, you know, if modern medicine worked in such a way that it's just lack of knowledge that prevents us from a lot of
                                         
                                        allowing any one certain person to live, you know, for a long time.
                                         
    
                                        In other words, oh, yeah, they've got congestive heart failure.
                                         
                                        If we just had enough knowledge to do something to reverse that, they would live longer.
                                         
                                        If that were true, there'd be at least two or three, 400-year-old people running around just by chance.
                                         
                                        And the fact that the lifespan seems to be capped out at 120, and that's in extreme cases.
                                         
                                        The average lifespan being significantly less than that.
                                         
                                        And a lot of these people who live to be 120, it's not because of modern medicine.
                                         
                                        They just don't ever get sick.
                                         
                                        There's groups of people in the Ural Mountains that drink vodka and smoke cigarettes every day,
                                         
    
                                        routinely live to be 100 plus, but they never see a doctor.
                                         
                                        And that's the thing is that, you know, the key to living to be 120 is don't get sick.
                                         
                                        Well, we don't have any control over that.
                                         
                                        Having good genetics helps.
                                         
                                        for sure. But again, you don't have any control over that either. So anyway, I'm always
                                         
                                        a bit skeptical of this, although I understand that aging is simply a physiologic process
                                         
                                        that at some point we may be able to reverse that. Should we? I don't know. What if it's
                                         
                                        fabulously expensive, then only the rich get to live a long time and the rest of us get to
                                         
    
                                        just, you know, die on our regular schedule. If it's, in
                                         
                                        insanely cheap, then we have a problem with overpopulation, but it may drive our quest to get
                                         
                                        off this planet and colonize other worlds. Who knows? So, you know, science fiction has studied
                                         
                                        these things. Significantly, in Frank Herbert's Dune, the Spice Melange had life-prolanging
                                         
                                        properties, but it was fabulously expensive.
                                         
                                        So wars were started over it, and that wasn't the only thing it did.
                                         
                                        It did all kinds of stuff, including giving people a limited ability to see into the future.
                                         
                                        And that's why the guild navigators, oh, blah, blah, blah, blah, blah.
                                         
    
                                        That's, you know, I'm a big nerd now.
                                         
                                        Anyway, those of you have read Dune, understand it.
                                         
                                        If not, sorry I went down that rabbit hole.
                                         
                                        But anyway, this study has highlighted new facets of this relationship,
                                         
                                        but demonstrates how hallmarks of aging in the brain, gut and eyes,
                                         
                                        may even be reversed through fecal transplants.
                                         
                                        So, you know, a lot of pseudomedicine has to do with seeing a rat study that says,
                                         
                                        oh, you know, glutamine is good for X, Y, or Z in rats.
                                         
    
                                        And so let's just glutamines on over the counter.
                                         
                                        We'll just sell people glutamine and make these claims about it.
                                         
                                        And I just don't see a huge rush of people doing the same thing with fecal microbial,
                                         
                                        but anyway, it says the makeup of microbial communities in our gut is being shown to shape many different aspects of our well-being.
                                         
                                        We're starting to really see how inflammation can play an intermediary role when it comes to cognitive health.
                                         
                                        Now, this I do believe.
                                         
                                        One 2019 study offered some interesting insights to this space
                                         
                                        by showing the intestine to be the source of immune cells
                                         
    
                                        that reduce brain inflammation in multiple sclerosis.
                                         
                                        Later that year, we saw the approval of a drug designed to remodel the gut microbiome
                                         
                                        to reduce neuroinflammation for treatment of cognitive decline in Alzheimer's.
                                         
                                        And wait a minute.
                                         
                                        What is that one?
                                         
                                        Oh, okay, micro, it's, okay, I clicked on this study,
                                         
                                        microbiome altering Alzheimer's drug unexpectedly approved in China.
                                         
                                        It says in a surprise to many researchers around the world,
                                         
    
                                        Chinese authorities recently approved a novel drug
                                         
                                        claimed to improve cognitive function in patients with Alzheimer's disease.
                                         
                                        The drug derived from a marine algae or algae is the first new Alzheimer's drug
                                         
                                        to reach the market anywhere in the world in 20 years.
                                         
                                        suggested to reduce neuroinflammation by modulating a person's gut microbiome.
                                         
                                        Now, isn't that interesting?
                                         
                                        I'd like to see the data on that.
                                         
                                        Well, anyway, results from a study published in Nature aging last year
                                         
    
                                        provided particularly compelling evidence of the influence of gut bacteria on the brain
                                         
                                        to focus specifically on brain aging showed that transplanting fecal matter
                                         
                                        from young mice into old mice.
                                         
                                        See young people when shit becomes valuable
                                         
                                        the poorer will be born without assholes.
                                         
                                        That's a saying from my past.
                                         
                                        Old mice could reverse some aspects of age-related brain deterioration.
                                         
                                        So young people's fecal matter will have a higher street value than old people's fecal matter.
                                         
    
                                        Not interesting.
                                         
                                        Yeah, learning ability, long-term memory was improved.
                                         
                                        These were considered among the first insights in how gut bacteria can influence brain aging
                                         
                                        in mammals.
                                         
                                        Now, the latest findings in this area come from science at some university of East Anglia,
                                         
                                        who have added yet more weight to the idea.
                                         
                                        Gut bacteria can influence brain health via inflammation.
                                         
                                        They've simultaneously shown how these microbial communities can influence certain biomarkers of aging,
                                         
    
                                        not just the brain, but the gut itself and also the eyes.
                                         
                                        They transplanted fecal matter from healthy young mice to aged mice.
                                         
                                        and I would like some healthy young fecal matter, please.
                                         
                                        And also reverse experiments where the younger mice receive fecal matter from the older ones.
                                         
                                        They then analyzed a rage of inflammatory biomarkers across the bodies and the animals
                                         
                                        and teased out some valuable insights.
                                         
                                        Following these transplants, the young mice showed a loss of integrity, of course,
                                         
                                        because the old have no integrity.
                                         
    
                                        Oh, oh, oh, oh, in the gut lighting.
                                         
                                        Okay, they showed a loss of integrity in the gut lining,
                                         
                                        which allowed bacterial products to pass through and circulate around the body.
                                         
                                        Okay, yes, okay, I understand this.
                                         
                                        They're talking about tight junctions in the gut.
                                         
                                        And these are places where cell walls, well, we don't really have cell walls,
                                         
                                        that cell membranes, meet each other, and if they are tightly bound, then that makes a very
                                         
                                        tight junction, hence the name, that doesn't allow anything past it.
                                         
    
                                        You know, it acts as a wall, but if they're loose, then toxins and bacterial parts and
                                         
                                        different antigens can breach that wall.
                                         
                                        and cause inflammation in the tissues on the other side of that so-called tight junction that is now loose.
                                         
                                        So this triggers the immune system, in turn, inflammation causing overactivation of certain immune cells in the brain
                                         
                                        and elevating levels of proteins linked to retinal degeneration in the eyes.
                                         
                                        That's amazing.
                                         
                                        Conversely, the scientists found that these sorts of markers could be reversed in the older mice
                                         
                                        by implanting them with fecal matter from younger mice.
                                         
    
                                        This also boosted levels of healthy bacteria previously shown to be linked to good health in mice and humans.
                                         
                                        So this is an interesting study.
                                         
                                        There is another way to do this, though.
                                         
                                        This just struck me as I'm reading this.
                                         
                                        There is a medical food called enteragam.
                                         
                                        Enterogam is serum bovine immunoglobulins.
                                         
                                        and if you have loose junctions in your gut,
                                         
                                        you could do something to try to tighten them up,
                                         
    
                                        i.e. do a fecal transplant or other things that you could use.
                                         
                                        I think the drug lubeyprostone, aka Amatiza,
                                         
                                        also tightens those junctions.
                                         
                                        But the other thing you could do is just block things
                                         
                                        from broaching those loose junctions,
                                         
                                        and that's what that enterigam does.
                                         
                                        the serum bovine emuloglobulins bind to all these antigens and quote-unquote toxins and bacterial parts and things like that that cause inflammation and they bind to them preventing them from being exposed to the tissue that then causes inflammation so that may be something so yeah this is this bears some now listen if my mind is just as spry as it ever was and my eye is
                                         
                                        just as, you know, has just the resolution that it always did.
                                         
    
                                        But my body is still falling apart.
                                         
                                        That's going to be infuriating to me.
                                         
                                        I mean, if I can still see that half of a, you know, tit tattoo on a redneck woman with tank top on,
                                         
                                        which was always kind of my thing.
                                         
                                        I know it's weird.
                                         
                                        And because you always want to know what's the other half of the tattoo shows.
                                         
                                        and I can think about it, I can process that, and I can see it with high resolution,
                                         
                                        but there's nothing I can do about it that will be irritating.
                                         
    
                                        So we've got to figure out whether fecal transplants reverse signs of aging
                                         
                                        in other parts of the body as well, if you know what I mean.
                                         
                                        Anyway, that's very, very interesting.
                                         
                                        All right, let's move on from there, and let's take some of your voicemails.
                                         
                                        One thing.
                                         
                                        Don't take advice from some asshole on the radio.
                                         
                                        All right, my friend.
                                         
                                        Thank you very much.
                                         
    
                                        let's do this one
                                         
                                        Hey Dr. Steve, it's Ben from Connecticut
                                         
                                        Hey Ben
                                         
                                        Just a quick question for you
                                         
                                        I recently had a
                                         
                                        Pylenitis cyst
                                         
                                        It had to be
                                         
                                        surgically operated on
                                         
    
                                        I don't believe they completely
                                         
                                        removed it
                                         
                                        As they mentioned
                                         
                                        That the transfer of currents
                                         
                                        Is reasonably high
                                         
                                        Yeah, that's true anyway
                                         
                                        But to prevent future
                                         
                                        occurrences of that
                                         
    
                                        Should I've been told
                                         
                                        to do full hair removal
                                         
                                        on my back
                                         
                                        and
                                         
                                        buttle region
                                         
                                        and so the doctor
                                         
                                        recommended Nair
                                         
                                        but I'm listening to your last podcast
                                         
    
                                        you recommended not to use Mare
                                         
                                        anywhere near the rectum
                                         
                                        so I'm wondering what my options are
                                         
                                        if I should just
                                         
                                        grit my teeth in barrel wax
                                         
                                        I'm not really up on that kind of thing
                                         
                                        so please let me know
                                         
                                        appreciate it
                                         
    
                                        yeah now we talked about this recently
                                         
                                        and I've got another person that
                                         
                                        did a thing that responded to this
                                         
                                        hey Dr. Steve
                                         
                                        and everybody in the studio
                                         
                                        a couple things are not related
                                         
                                        when I was in the Marine Corps
                                         
                                        I neared my body from head to toe
                                         
    
                                        and it hurts in certain areas
                                         
                                        yes it does
                                         
                                        I don't know I wasn't the smartest person
                                         
                                        but I did it on a dare
                                         
                                        okay so
                                         
                                        I
                                         
                                        we covered this long time
                                         
                                        ago, if you join
                                         
    
                                        our Patreon, I believe
                                         
                                        that show is up, and if it isn't,
                                         
                                        I'll make sure it is up pretty quickly
                                         
                                        where we had the
                                         
                                        ass crack challenge.
                                         
                                        And P.A. John
                                         
                                        was going to nair his ass crack,
                                         
                                        and double
                                         
    
                                        vasectomy turd was going
                                         
                                        to shave his ass crack, and then
                                         
                                        I was going to have mine
                                         
                                        waxed. And
                                         
                                        doing research on this, we told
                                         
                                        John not to do it, because everything
                                         
                                        I read said that if you put
                                         
                                        Nair on that sensitive
                                         
    
                                        part of your body near the anus
                                         
                                        you can really cause some real
                                         
                                        damage so we only did the two
                                         
                                        legs of that
                                         
                                        and Todd
                                         
                                        found that if he shaved his ass
                                         
                                        crack it was great for like a day
                                         
                                        and then you get ass crack stubble
                                         
    
                                        because when you shave you
                                         
                                        make a
                                         
                                        square end on the hair
                                         
                                        but if you wax your hair
                                         
                                        then it will grow back tapered.
                                         
                                        So if you let it grow back, it doesn't cause irritation as it's growing back.
                                         
                                        And we found all this to be true.
                                         
                                        So I went and looked, and there are a couple of people responded to this saying that there are
                                         
    
                                        no hair, intimate private slash at-home hair removal creams.
                                         
                                        And there are.
                                         
                                        And some of these are marketed for people to use in the genital.
                                         
                                        regions except that it says let me just read you some of this is one from one of the ones
                                         
                                        that says it's for the genital region it says save yourself pain pain pain maybe he was doing the
                                         
                                        the spock mine meld with the horta pain okay going back too far sorry it says not for balls
                                         
                                        I got to let you guys know do not buy if you're planning on using this for you sack
                                         
                                        I want to use this all over down there, and for my butt worked fine,
                                         
    
                                        but please do not apply to your sack.
                                         
                                        By no means is my skin sensitive at all,
                                         
                                        and after one minute application, but the sack was on fire.
                                         
                                        I immediately rinsed it off, but it was too late.
                                         
                                        My sack was burn, and I wasn't able to get out of the shower.
                                         
                                        The pain was so severe.
                                         
                                        I was seconds away from going to urgent care.
                                         
                                        I'm writing this to save you from thinking it does a damn thin.
                                         
    
                                        for your balls. Once I'm healed, I'll only ever shave that area again. The advertisement is false and
                                         
                                        shouldn't be allowed to, oh, it shouldn't be allowed on balls. Okay, let's see here. Let's find
                                         
                                        another one. This one says, find something else. This product needs to be more specific on what
                                         
                                        skin and hair type it works. I used the whole container, waited the six minutes. Most of the hair
                                         
                                        didn't fall off as I had to pull most of it by hand. It was a messy experience. Here's another.
                                         
                                        the one. The packaging for the product expressly states it is for the, quote, genitals, unquote.
                                         
                                        There's even an illustration of a man's bikini brief clad bulge on the back of the package to go along with this claim.
                                         
                                        Yet in the fine print, you find it is not for the penis. Guess what? You deliberately deceptive manufacturer.
                                         
    
                                        The penis falls under the heading of, quote, genitals, unquote. Well, that indeed it does.
                                         
                                        this person said without describing the embarrassing particulars of this product
                                         
                                        caused severe burns despite using the product as the instructions directed
                                         
                                        and performing a test skin patch first
                                         
                                        I sought medical attention from a family member
                                         
                                        that was my cousin
                                         
                                        um okay uh let's see here
                                         
                                        first attempt waited three minutes tested nothing another minute
                                         
    
                                        a little came off in the shower put more on the second attempt
                                         
                                        Big mistake, took the hair off, then burned my balls.
                                         
                                        You get nothing.
                                         
                                        Hit the wrong sound bite, but that actually worked.
                                         
                                        Okay, let's see.
                                         
                                        I'll do one more.
                                         
                                        This one says, I'm not even trying it due to the directions.
                                         
                                        Okay, I'm not.
                                         
    
                                        It says here, how can something be for your intimate areas
                                         
                                        when it requires a spatula to apply it
                                         
                                        because it should not touch your fingers.
                                         
                                        Good point, my friend.
                                         
                                        All right.
                                         
                                        Ouch, I got to use this on my neck as well as my friend.
                                         
                                        Now listen, okay, this person asked about pylonidal cysts
                                         
                                        and then was talking about nair.
                                         
    
                                        If you used it, so let's talk about what a pylidotidocyst is.
                                         
                                        This is a cyst you get at the bottom of your tailbone,
                                         
                                        and it's called pylonidal because pilo means,
                                         
                                        hair and nital means nest.
                                         
                                        So when you open these
                                         
                                        things up, often there will be a
                                         
                                        nest of hairs that have grown
                                         
                                        under the skin, and then
                                         
    
                                        it eventually gets infected, so it's
                                         
                                        a big mess of pus and
                                         
                                        a nest of hairs.
                                         
                                        And hence the name
                                         
                                        pylonidal cyst.
                                         
                                        And it looks like a big
                                         
                                        zit at the bottom of your tailbone.
                                         
                                        It's more common in men than women.
                                         
    
                                        And it usually happens
                                         
                                        due to sitting
                                         
                                        leaning back
                                         
                                        so people who recline
                                         
                                        when they sit are more likely
                                         
                                        to get this truck drivers will get it
                                         
                                        and people who sit a lot
                                         
                                        will get it and
                                         
    
                                        they can drain it but
                                         
                                        it will usually recur so then
                                         
                                        normally the surgeons recommend that
                                         
                                        the thing be removed but then
                                         
                                        you've got to change the way that you sit
                                         
                                        and yes
                                         
                                        one way to avoid ingrown hairs
                                         
                                        is to avoid
                                         
    
                                        having hair in that area at all
                                         
                                        So I would wax it rather than nair it.
                                         
                                        Anything that will reduce the inflammation of the skin as the hair grows back is, I think, would be beneficial.
                                         
                                        Or you could have it lasered.
                                         
                                        Just laser it.
                                         
                                        It would be two or three treatments you'd be done.
                                         
                                        You wouldn't have any hair down there.
                                         
                                        That'll get rid of the hair follicles and everything.
                                         
    
                                        Now, my friend Chanda tells me that that works better on people with.
                                         
                                        darker, coarser hair. So if you're blonde with very fine hair, I'm going to posit that you probably
                                         
                                        don't have a pylonidyl cyst if you have very fine blonde hair in the tailbone region. But if that's
                                         
                                        not the case, then absolutely go for it and get it lasered. So that's what I would do to prevent it.
                                         
                                        As a matter of fact, while I was talking about this, I was searching, and I found that research evidence
                                         
                                        suggest there is a significant reduction in recurrence rates of pylidyl cyst with the use of
                                         
                                        laser hair removal.
                                         
                                        Well, I'm going to give myself a dang bell on that one.
                                         
    
                                        Give yourself a bill?
                                         
                                        I just did.
                                         
                                        Thank you, sir.
                                         
                                        So how about that?
                                         
                                        Yeah, so right now, that would be my top recommendation based on just my own intuition
                                         
                                        and based on the little bit of evidence that I've found doing a search while I was
                                         
                                        answering this question so all right very good um we've got this is an interesting one here and
                                         
                                        this has nothing to do with medicine but it has something to do with something that we talked about
                                         
    
                                        last week hey dr steve this is travis in east tennessee hey travis how are you guys doing
                                         
                                        good man how are you just uh heard your podcast uh mentioned in dollywood and thought i'd give you
                                         
                                        a little bit of history on it in case you didn't know um started out in the 1960s or 70s as
                                         
                                        railroad and the park's always been themed around that steam train that rides through the
                                         
                                        park and originally it was yeah one thing about dollywood particularly you little kids love is this
                                         
                                        dang steam engine train that will take you around this cul-de-sac and all around the park
                                         
                                        and people do love that thing and when it comes you know they have the conductors out there
                                         
                                        how do they do and all this stuff it's really it really is a cool thing and it's easy to get on
                                         
    
                                        you know you all even when the lines are bad at dollywood you can usually get on the first or second
                                         
                                        time um like said rebel railroad and it was themed to be uh civil war times and then it became
                                         
                                        gold rush junction and then silver dollar city and well was it union or was it confederacy that
                                         
                                        would be, since it's called Rebel Railroad, I think maybe that's why it's not called that
                                         
                                        anymore.
                                         
                                        And the folks that bought it as Silver Dollar City changed the name to Dollywood and did a partnership
                                         
                                        with Dolly Parton.
                                         
                                        And even up into the 1990s, they still had some of those old buildings up where the train
                                         
    
                                        turns around, and they would have Cowboys come and, you know, rob the train.
                                         
                                        It was a lot of fun.
                                         
                                        It was really neat.
                                         
                                        Yeah, so if you want to have that experience still, and thank you, Travis, go to Tweetsie Railroad, and there are probably a bunch of these things.
                                         
                                        But I remember our littlest one was a big fan of Thomas, the engine or whatever he was, and they would roll a different front onto that.
                                         
                                        And all of a sudden, Thomas the train was there, and he would take you around, and the Tweetsy Railroad thing.
                                         
                                        And they still have scenarios and little action pieces that they do when you go by.
                                         
                                        And at Hollywood, at Halloween, kind of the same thing, right?
                                         
    
                                        At Halloween, it's all scary themed stuff, you know, ghouls and goblins and things that you see as you go by all these different areas on the railroad.
                                         
                                        But anyway, enough about Tennessee and North Carolina minor theme parks,
                                         
                                        although I guess Dollywood no longer is a minor theme park
                                         
                                        because it has the number one wooden roller coaster in the world,
                                         
                                        which is called Thunderhead, and it is nuts.
                                         
                                        It is really nuts.
                                         
                                        So I always thought that Dollywood would be a bunch of painted concrete
                                         
                                        and a bunch of just schlocky stuff,
                                         
    
                                        but it's very nice theme park if you're into that sort of thing.
                                         
                                        All right.
                                         
                                        Let's see here.
                                         
                                        How about this one?
                                         
                                        Hey, Doc Steve.
                                         
                                        It's Matt and Christy in Charleston, South Carolina.
                                         
                                        Hey.
                                         
                                        We have some friends that are, you know, are.
                                         
    
                                        By the way, Matt and Christy, we will be in your area in the next few months as we head down to the Charleston area to do a vacation.
                                         
                                        And that'll be in July sometime, you all.
                                         
                                        So we'll make sure that we've got some evergreen shows running or we'll run some.
                                         
                                        stuff ahead of time, but anyway.
                                         
                                        A child is friends with their child, and so now we are forced to be their friends.
                                         
                                        Okay, understood that.
                                         
                                        They have another child that has something called panda, and some kind of infection that's led to, like, neurological problems in the brain or something like that.
                                         
                                        Can you help us understand what it is and what they are going through, so maybe we can be better friends?
                                         
    
                                        Yeah, yeah, yeah.
                                         
                                        It's, well, being better friends in this case just means being understanding of the situation.
                                         
                                        Pandas is short for pediatric, autoimmune, neuropsychiatric disorders associated with streptococcal infections.
                                         
                                        And when kids get this, if they get OCD or a tick disorder or both, they suddenly appear following a strep throat infection or any other.
                                         
                                        sort of strep infection, could be scarlet fever, or, you know, I don't know if this has ever been
                                         
                                        associated with strep versions of impotigo, which is a skin infection, so I'll have to look
                                         
                                        into that.
                                         
                                        The diagnosis of pandas is further supported if the symptoms of obsessive-compulsive disease
                                         
    
                                        or ticks suddenly become worse following a strep infection.
                                         
                                        and it's usually dramatic and happens overnight and completely out of the blue
                                         
                                        and can invoke motor ticks that'd be just twitching of the face or the body
                                         
                                        or vocal ticks or both obsessions compulsions are both
                                         
                                        and they may become moody and irritable and have panic attacks
                                         
                                        and show separation anxiety and those kinds of things
                                         
                                        and these damn strep bacteria are recognized as foreign bodies in the child's system
                                         
                                        and the immune system reacts to these molecules by producing antibodies as we're well aware
                                         
    
                                        now most people have some expertise on immunology these days after two years of pandemic
                                         
                                        and vaccines and all that stuff but the immune system is
                                         
                                        supposed to react only to the strep molecules, but in this case, they also react to the human
                                         
                                        host molecules that are similar.
                                         
                                        And so these antibodies attack, these sort of mimicked molecules in the child's own tissues.
                                         
                                        And this is similar to rheumatic fever, where people get strep infection, and then all of a sudden
                                         
                                        the body produces antibodies to joints or heart tissue, you know, cartilage in the heart, that
                                         
                                        kind of thing.
                                         
    
                                        So it's not that different.
                                         
                                        But in this case, it's causing neuropsychiatric problems.
                                         
                                        And there are some cross-reactive antibodies that target the brain, and that's what's causing
                                         
                                        these OCD and these ticks, and then causes this panda syndrome.
                                         
                                        So it is diagnosed not with the lab test, but by criteria.
                                         
                                        And so the diagnostic criteria are, as we talked about, OCD, tick disorder, pediatric onset, episodic course of symptoms.
                                         
                                        In other words, if they get exposed to strep again, it gets worse.
                                         
                                        And association with any strep infection.
                                         
    
                                        And then the key to it is that it was abrupt.
                                         
                                        onset or abrupt worsening of symptoms.
                                         
                                        And what do you do when you treat this?
                                         
                                        Well, you know, they can do a strep tighter and see if it's really high on these kids.
                                         
                                        That just shows that they have high circulating antibodies to strep.
                                         
                                        And then, you know, to treat it, they just treat it with antibiotics.
                                         
                                        So that's for these acute episodes.
                                         
                                        They treat the strep infection causing the symptoms.
                                         
    
                                        And usually the great thing about strep is almost all the time you can treat it.
                                         
                                        with simple penicillin.
                                         
                                        These dumb bacteria don't seem to be able to mount a response to penicillin,
                                         
                                        probably because they're so sensitive to it.
                                         
                                        It just kills them all, and they can't develop resistance to it.
                                         
                                        They recommend that toothbrushes be replaced or sterilized after antibiotic treatment
                                         
                                        to make sure they don't reinfect themselves and make sure that nobody in the
                                         
                                        the family are strep carriers, including, by the way, dogs.
                                         
    
                                        Dogs can have been implicated as carriers of strep and kids with recurrent strep.
                                         
                                        Now, the children that have OCD usually benefit from standard medications and behavioral therapies,
                                         
                                        cognitive behavioral therapy, that kind of stuff, and they can use even serotonin re-uptake inhibitor
                                         
                                        type medications for these kids, and there are medications for ticks, and so we just sort of
                                         
                                        basically break down the symptoms into their component parts and treat those separately.
                                         
                                        We never love to put kids on SSRIs when they are, you know, ever.
                                         
                                        And so they want to start low and go slow, so they'll often use liquid preparation
                                         
                                        and use the tiniest amount that you possibly can.
                                         
    
                                        And this should be done by a specialist, in my opinion.
                                         
                                        And then for the very worst cases, you can give them intravenous immunoglobulin sort of overpower and reduce the effectiveness of the local antibodies.
                                         
                                        Or you can do plasmic exchange just to get those antibodies out of there.
                                         
                                        The problem with that is, you know, these treatments can increase your risk of infection, and there are always risks with invasive procedures.
                                         
                                        like that so that should be reserved for just the worst possible cases so um you know there is clinical
                                         
                                        research out there go to clinical trials.gov and you can look up pandas syndrome make sure you have
                                         
                                        the S at the end and see if there are any clinical trials that your kid or your friend's kid could
                                         
                                        enroll in that would be something for the parents to do but you could ask me hey have you guys looked
                                         
    
                                        at clinical trials dot org particularly if they're very distressed about what's going on with their
                                         
                                        kid. I don't know the severity of the kid's illness.
                                         
                                        So anyway, all right, very good.
                                         
                                        Well, listen, we had a little bit of feces talk and then some more interesting science stuff.
                                         
                                        So I appreciate you all being with us.
                                         
                                        We'll have a normal show next week, which will be in just about four or five days.
                                         
                                        Until that time, we can't forget Rob Sprantz, Bob Kelly, Greg Hughes, Anthony Coomia, Jim Norton, Travis Teff, that Gould Girl, Lewis, Lewis Johnson,
                                         
                                        Paul Offcharski, Chowdy, 1008, Howdy, Guplunk, Eric Nagel, the Port Charlotte Hoare, the Saratoga Skank, the Florida Flusi, the St. Pete Barkeep Blower, the Tampa Dali Museum, Diddler, Percy Dom, Roland Campos, sister of Chris, Sam Robert, she who owns pigs and snakes, Pat Duffy, Dennis Falcone, Matt Klein Schmidt, Dale Dudley, Holly from the golf, Christopher Walkins double, Steve Tucci, the great Rob Bartlett, Vicks, Nether Fluids, Cardiffelette,
                                         
    
                                        electric. Casey's wet t-shirt. And I always thank Carl's deviated septum, but that's really
                                         
                                        Carl's actual deviated septum. And one of my friends named Mark pointed out to me that
                                         
                                        that's also my name on Discord, which means that I'm thanking myself in a weird way.
                                         
                                        So I'm going to change that to Carl's malformed foot.
                                         
                                        producer chris jenny jingles the inimitable
                                         
                                        Vincent paulino everybody
                                         
                                        Eric Zane Bernie and Sid
                                         
                                        Martha from Arkansas's daughter Ron Bennington
                                         
    
                                        and of course our dear departed friends
                                         
                                        GVAC and Fez Watley
                                         
                                        whose support never went unappreciated
                                         
                                        listen to our SiriusXM show on the Faction Talk
                                         
                                        channel SirsXM channel 103
                                         
                                        Saturdays at 7 p.m. Eastern Sunday at 6 p.m.
                                         
                                        Eastern on demand and other times
                                         
                                        at Jim McClure's pleasure. Many thanks to our listeners
                                         
    
                                        whose voicemail and topic ideas make this job very easy.
                                         
                                        Go to our website at Dr. Steve.com for schedules, podcast, and other crap.
                                         
                                        Until next time, check your stupid nuts for lumps.
                                         
                                        Quit smoking, get off your asses and get some exercise.
                                         
                                        We'll see you in one week for the next edition of Weird Medicine.
                                         
                                        These effing allergies, Jesus.
                                         
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