Weird Medicine: The Podcast - 547 - Stoneman Syndrome and Superfetation

Episode Date: April 15, 2023

Dr Steve, DNP Carissa, Dr Scott and Tacie discuss: Ochoa syndrome Tapeworms for weightloss Stoneman syndrome Superfetation Gout Framingham risk scores Deviated Septae Dementia, Alzheimer Type DM drugs for weightloss Please visit: stuff.doctorsteve.com (for all your online shopping needs!) ed.doctorsteve.com (for your discount on the Phoenix device for erectile dysfunction) simplyherbals.net/cbd-sinus-rinse (the best he's ever made. Seriously.) roadie.doctorsteve.com (the greatest gift for a guitarist or bassist! The robotic tuner!) Also don't forget: Cameo.com/weirdmedicine (Book your old pal right now while he’s still cheap! "FLUID!" Most importantly! CHECK US OUT ON PATREON!  ALL NEW CONTENT! Robert Kelly, Mark Normand, the O&A Troika, Joe DeRosa, Pete Davidson, Geno Bisconte. Stuff you will never hear on the main show ;-) Learn more about your ad choices. Visit podcastchoices.com/adchoices

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all right, very good. Um, let's see, we did the, okay, the Jenner retraction from last time. So I don't have anything. Well, you guys have anything? No. Nobody. Tacey, you got some topics? I have some topics. All right. Here we go.

It's Tacey's Time of Topics, a time for Tacey to discuss topics of the day. Not to be confused with Topic Time with Harrison Young, which is copyrighted by Harrison Young and Area 58 Public Access. And now, here's Tacey. Hello, everyone. We're going to have snotty topics today. Generally just because I'm snotty. God, who isn't? Okay, so we're in Upper East tonight.

Tennessee, the dog woods and all these flowering trees have opened up their flower. They're beautiful. Bradford Pears. Yeah, Bradford Pears. That's the one. That's one that can kiss my ass. Keele me. So, anyway,

it's supposed to be a freeze tonight, and I hope they all fucking die. God. Anyway, all right, so go ahead. Okay. Topic number one. In 2008, a man in U.S. was diagnosed with frowning syndrome. Facial contractions gave him a permanent frown.

Hmm. Facing Bidgge face. Farrowning syndrome? Yes. Okay, so... I think I have that. It's also known as... Now, there are people with a genetic syndrome called Ochoa syndrome. They exhibit characteristic frown-like facial grimaces.

when they try to smile or laugh. It's often described as inversion of facial expression. So when they try to laugh, I've seen people like that. But when they laugh, their mouth goes down instead of up. I think, as a matter of fact... Wonder if there's a Botox that can fix that. I mean, if they can... Because, you know, they do the lip flip now.

That is true. I don't... I think what it would do is just make them not be able to smile at all. Which would be better. My opinion, been frowning every time. Maybe. There are some famous people who have it. I've seen where they laugh and they're like that.

Oh. You know, they probably look. I don't know so much. Yeah, yeah, yeah. I think, who is that? There's some famous people. Let me Google famous people with Ochoa syndrome. Famous. Oh, everybody loves this when I do this.

Oh, yeah. When you Google while we're on the radio. 35 seconds of the show, we're off the rails already. That's a new record. Well, and then, yeah, everybody that it gives me here is nobody is famous. That's exactly.

Poor Chris. Always, always my fault. Yeah, it's okay. Let's see. Yeah, no one famous with Ochoa syndrome according to Google anyway. Okay, very good. So topic number two.

That was it? Yeah, she just, she reads the headlines. Yeah, so the first three are just topics. It's fine. The fourth one gets it a little deeper. Tacey's time of topics. It doesn't technically say Tacey's time of going into death. Well, it depends on where the information is coming from.

Right, okay, very good. Okay. The second one is in 2012. A man had a 24-inch long tapeworm removed. Oh, I thought that was going somewhere else. He lost a lot of weight and was malnourished, CBS News. Okay, so tapeworms. uh chrisa you want to talk about tapeworms no but their life cycle no okay that's fine but 24 inches

i thought that was pretty long and 24 inches yeah oh that's nothing i've i thought we had somebody that had one that was you know 12 feet or something yeah something bizarre well screw cbs news then because that was not a story back in the day a million years ago before we had phentermine and ozempic and stuff like that, people would take tapeworm eggs and to lose weight. Not opposed to that. Yes. Did they really? Yeah.

I did not know that. Who did that? I feel like they still do that. Yeah, I'm not opposed to it. You think they do? Mm-hmm. You've seen this? Mm-hmm.

Oh, really? Why would you do that when you've got other things like... Well, you can't get a Zipik now because of the whole dietic tapeworm. I would say probably fewer side effects if you use tapeworms than some of those other things. Well, maybe, but I mean... Cheaper? Easier access. Tapeworm infection causes upset stomach and weight loss,

not wanting to eat loose stools. Not wanting to eat loose stool. Ozimic causes exact same thing, except for a little bit of constipation. That's what I'm saying, dude. I think you probably have fewer side effects from the tapeworm. Cravings for salty food. So I wonder if the tapeworm likes salt,

and somehow it's kind of controlling you to eat certain things that it likes. Oh, how creepy is it? That's pretty interesting. If you can control what you want. Now we've got her attention, Dr. Steve. She's in the game now. I'm in. Tapeworm life cycle.

So how do we get rid of them? Medication. And it's very easy to... And do you poop them on out? Yep. Yep, that's what you do. Do you poop them out alive or dead? Well, they die and then they let go and then you poop them out.

Oh, so they're attached. Of course they help. Actually, you're pooping out segments of them constantly. Oh, nice. Like normal people are? Have you ever seen dogs that have worms? Yes. And when I poop them out, it looks like a pile of spaghetti noodles.

Oh, now that's probably round worms. Yeah. Yeah. It's still a worm in your tummy. Google, okay, you want to Google image something that will make you vomit, as we say in up East Tennessee? Is Google rectal ascarus. Ascarus is a type of round worm, ASC-A-R-I-S. Well, a matter of fact, I'm going to counsel you not to Google that.

I've done it once, and that was enough. It's too late. We use that. We use the picture that you're going to see with the guy who's spread-eagled on his stomach with worms coming out of his ass. I mean, there's just a giant mass that looks like thick spaghetti. We use that on the album cover for my grind cord band, which was called ass maggot. So there you go. Nice. Yeah, the life cycle of tapeworms includes egg, a fruit.

a free living larval stage pro-circoid and then a plero circoid in the first and second intermediate host so this is very complex so humans ingest raw or undercooked infected

meat and then the tapeworm grows and then they crap out of these eggs and things like that in the feces and then cattle accidentally eat it because they're eating vegetation that's contaminated by it. And then they hatch and penetrate the intestinal wall and circulate to the musculature. That's what I was saying

it the way. Yes. What's his name? George Takease says it. Musculature. And then they, these spheres develop into what we call cystocircite in muscle tissue. And then people eat them and then, you know, rinse and repeat. Now, humans can sometimes get the cysts growing and their muscles is extremely painful when that happens. And that's if you accidentally eat contaminated vegetables that have been contaminated by stool from either an animal or a human that has had tapeworm infection. So if you skip going through the pig, then you end up getting the cysts growing in. your muscles. I've actually never seen that.

I've seen a picture of it. You take an x-ray of someone's arm, and you'll see all these little sort of cyst-like things in the muscle tissue. It's gross. Yeah, it's terrible. Topic number three. In 2010, a woman was diagnosed with Stone Man Syndrome. Oh, yeah.

Produced excess calcium deposits in her muscles, leading to muscles and joints becoming very hard and stiff. Science Daily. Okay, so. Hey, this next one is more than just a topic, and I don't care if you think it's fine. It's just as what it is. It's a good topic. Stone Man Syndrome is also called fibrodisplasia ossifacans progressiva, or FOP, or FOP.

It's extremely rare, one in two million genetic disorder, and it's characterized by ossification of the skeleton and connective teeth. We call that ectopic ossification because it's, ectopic just means it's somewhere where it's not supposed to be. And it leads to progressive fusion of the skeleton all over the place. And if you Google image someone with Stone Man Syndrome, they've got, you know, skeletons of these people. It's all just like one bone, basically. It's rough. Do you ever see anybody with that, Carissa? No.

No, me neither. Another one I've never seen. I have seen one case of tetanus. though. I'm the only person I know in medicine that's actually, other than the people who were on that case and some of them are dead now because it was so long ago that have actually seen a case of tetanus.

And why is that? Not because tetanus is gone. Because you're old? We're fully vaccinated. Well, yeah, that. That's why I've seen one, but why we don't have them is because we vaccinated against tetanus. Right on. That's good.

Thank you. Yeah, it's very good. Oh, the titan shot causes more. problems than tetanus does. Yes, of course. Of course it does because we have zero cases of tetanus and we vaccinate everybody. So how many cases

of tetanus did we have in this country last year? Let me see. Cases of here we go again. Of tetanus. Here we go. In the U.S.

All right. So 33 last year. Wow. Okay. So are you off your high horse. I am. Okay. Topic number four,

which is also a story. But also a topic, right? Also a topic. Okay. Sent to me by Scott. Oh. Oh. How do you get pregnant when already pregnant? Excellent. You ovulate and then have intercourse. Is this tasty topic time or steatine time? I thought you were asking a question.

That's the topic. Okay. If I had a bit of a bit of a bit of. I'll give you a bill right now. Okay, I'll give you a bell. Give myself a bell. Damn it. See, see what you just did? I was trying to be, Mr. Nice guy.

Look what happens. It's called superfetation. It's very real, but possible. It's unlikely because, one, you stop ovulating. Two, it gets tough for another fertilized egg to implant once the first one is nestled there. The uterine lining thickens to support the first egg, which makes it hard for another to attach. Yep.

Three, you produce a mucous plug, which protects the uterus from infection. Oh, yeah. And keep sperm from passing through. Yeah. So that's one and how many? I've never heard of anyone ever getting pregnant while they were pregnant. Well, I haven't either. Well, let's see if it's further on down the line here.

What causes it? Okay. What if you ovulate while pregnant? You're pregnant while you're pregnant, I guess. Yeah, yeah. What if you have two uterite? Yeah, that happens sometimes. Or it could be a didelphic uterus.

Well, yeah, that's... Two separate uterite. More likely to cause a miscarriage, though. That's true, even if you only have one pregnancy in a didelphic uterus. That's one that's kind of blooped into two. They're usually conceived two to four weeks apart. What's the name of this pregnancy? Superfetation.

Superfetation. Superfetation. Yeah. According to my handwriting. Okay. Okay. This could be wrong. Timing, usually.

Oh, superfeitation. Yeah, like, yeah, okay. Oh, excuse me. Feetace. Feetation. Usually conceived two to four weeks apart, a handful of confirmed cases. Number one. So rare in humans, only ten confirmed cases.

Wow. Yeah, go. Jessica Allen. She was a surrogate. She had, quote-unquote, twins, but after DNA testing, it showed one was hers and the other was theirs. Really? So she got implanted, probably had an agreement not to have intercourse and did it anyway. Did it anyway.

Now, how far apart were they, like in weeks? I mean, I guess you could have one that's 16 weeks or, you know, much smaller than the other one, and they deliver them separately? I'm unable to provide that information at that. That wouldn't work, yeah, unless you did maybe a C-section. You have to keep them from going through labor. Well, it sounds like she had them, but then they DNA tested them. Right, so they were close in. But if you had one that was, say, 40 weeks and one that was 32 weeks, well, one that was, let's go farther.

It typically only happens two to four weeks apart. Okay, thank you. That answers my question because, like, how could you have that happen when, you know, and one fetus was 22 weeks, and the other one was 40 weeks, and then you'd have a real problem on your hands. Another famous person was Julia Grovenberg, 2010, conceived second. Two and a half weeks later, babies growing two different rates and two different uterine sex, two different due dates,

but by cesarean, they came on the same day. Number three was Kate Hill. Unlike the father. Yeah. Oh, you must have bail on that. Give thyself a bell. Number three, Kate Hill, two babies ten days apart after getting treatment for PCOS. Okay.

Polysistic overuses. Interesting to me. Yeah. So it happens so infrequently. Doctors haven't been able to really study it or say if risks are higher. Yeah, this thing here says the chance that you'll be affected by superfeitation is close to zero. Because you've got people Googling shit and just going, is this going to happen to me? Probably not.

That's the end of topic time. That's a very good topic time. Good one, yeah. It's Tacey's Time of Topics. All right, very good. Thank you, Tacey. I still have to get you an outro. I'll work on that.

Scott, you got anything? I've got a couple questions from the Fluid family. All right, that's right. When it's time. Yep, we had one from, who was that? The podcast guys? Yeah, podcast guys. And Suffrable Bastards Podcast.

Yes. Yeah, what you got? Well, they went to, I guess, one of their friends, Ray DeVito. Yeah, Ray DeVito. He's a comic. He's on Misery Love's company. Gotcha. Never heard of it.

I'm sure it's a good show. MLC. It's with Kevin Brannon. Okay, cool. Everybody is, Scott's not being disrespectful. No, not at all. He's literally not plugged into this world in any way. So, yeah, it's one of the reasons he's on the show.

Yes, I can play the dummy. The, so anyway, so poor, poor Ray, though, I feel sorry for him. He's a, I guess, a brother of mine. He has the gout. He got the gout. Oh, the gout. Yeah, so, so the, these, the, the, these insufferable bastards want to know what exactly is gout. Yeah.

Gout sucks. Gout is what. Total. Dr. Scott has gout. God, it's just. And I can always tell. Talk about insufferable. Drinking or eating.

What is it that triggers you? Shrimp. Shrimp mostly. Yeah. But, you know, sometimes just really sugary things can do it, too. But shrimp tends to do it the worst. I haven't had shrimp in a couple of years. Is that right?

Yeah. Last time I had shrimp, I had a shrimp and caper's pizza from our favorite Italian restaurant here locally. And a couple of large beers. And I woke up the next morning. Oh, boy. Hell, fire. Yeah. I was looking for a hack.

because it would have not been as unpleasant. Yeah. But, you know, but, you know, but, yeah, but, yeah, but gout is, a form of arthritis called, you know, it's caused by hyper eurycemia. Oh, very good. All right. Where is the gas to build up in your, in your body. That was an easy one, and he does not deserve them.

I get a bell, I get a bell. That's correct. So, um, but, and if you have too many, too many, um, and if you eat foods high impurions, they tend to lodge in your, in your joints, and they can lodge anywhere. Yeah. And, you know, the way I describe it to people is if you can imagine those medieval weapons where there was a stick with a chain and on the end of the chain was a metal ball with metal spike sticking up.

You can imagine a couple hundred of those stuck in your ankle joint or your toe or your knee and when you're walking. A couple hundred of them would be awfully big. No, they're teeny. Yeah. They're teeny. Yeah. That's what it feels like because it's not really glass cutting sharp and it's not really a stabbing pain.

It's more of a, just a horrible, miserable, yes, an awful thing. Does it make you want to vomit? Now, do you always get it in the same place? Yeah, so mine started in my big toe, which it usually does. Yep, that's a common place. It's not the only place. But not the only place. Yeah, you can technically get in any joints.

And I tell people that you think it hurts when it's in your big toe until it moves to a larger joint. Like your knee. Like your knee. Like I have it in my ankle. My ankle, I get it a lot. Yeah. So I get it there. I get at my toes, my middle toes on the other foot.

Sometimes I get in my hand occasionally. It's pretty nasty. So I have to be really cautious from what I eat and drink, of course. Well, you're all fucked up. Yeah, pretty much. Yeah, no. I've been to think it's for a long time, though. There's two ways you can get a high uric acid level in your body.

You could either produce too much or you can excrete too little. So back in the day, before people went to sort of cookbook medicine, We used to get a 24-hour urine in people on people and see if they were over-excreeders or under, I'm sorry, over-producers or under-execreaters. And then if you didn't produce enough, I mean, if you didn't excrete enough, I would give you a medication called Probenicid, which was dirt cheap. And it just made you piss out gout. You kind of see it almost gets a little foamy urine. You had to be very careful because in the beginning, if you precipitated out a bunch of yours, uric acid from your bloodstream, you can get uric acid stone.

So you had to take medication called potassium citrate to change the pH of your urine so that didn't happen. And then if you were an overproducer, you would take something to stop you from producing it, which back in the day was allopurinol. And now that we've got euloric and other things like that. But if you take that stuff during an acute... Gout attack, it will actually make it worse, which is weird. Right. Right. Yeah.

So during an acute gout attack, we'll use colchocene, which stops white blood cells from producing tubules so they can't move around. Well, how the hell that helps it? I don't know. But you would take enough. You'd keep taking it until you got sick to your stomach or shit your pants. Yeah, poop it out. And then you would stop. And or you can just do non-steroil anti-inflammatory drugs, like endomethicin.

or... In the Memphis works really well but it's really strong. Yeah. Sterewood, you know, sometimes just low-dose steroids. I don't help us as well too. But as far as... Hell, you're the doubt expert. is a key. Beer is a flare.

Yep. Yes, ma'am. Okay, so the FDA has ordered that euloric no longer be used as a first-line treatment. Oh, okay. Oh, and as a first-line treatment, right, right. Instead, it should only be prescribed to certain patients who cannot take alipurinol, or who experience severe side effects from it, from aliparinol. Very good. Yeah, thank you, Tacey. Oh, as a matter of fact, okay. You've got a medium bell. Harken to thine inner voice and give thyself a bell.

You know what? You gave me the first one. And you can suck it on the second. Oh, man. So let's talk about the things that you want to avoid. Yep. So Scott's alluded to some of these already, but red meat, some meats are high in purine. So what happens is your body breaks down purines into uric acid, and then too much can get into the bloodstream and cause these gout attacks. So red meat has a higher purine content than white meat.

But of the red meats, do anybody know which one is the worst? of the red meats I would say any kind of wild game and I get that from Sean so I'm saying he gets a he gets flares as a gut when he's wild meat

wild meat well okay but of the common does anybody know which is the worst one one that you could buy in a grocery store hamburger

nope dang it there goes my bail anybody what no no no chrissa

okay chrisa fell asleep about seven she's fine she dosed off I think the wine's kicking in blammer. It's a lamb. Lamb is the one.

So is shrimp common? Why lamb? Very common. Why lamb? I don't know. It's just got, purines are easy to break down into uric acid, I guess. I don't know. Or is shrimp just a thing that Scott's just got? No, no, no. That's very common. Certain fish are rich in purines. Especially shrimp, yeah.

Some of the shellfish, yeah. Go ahead. You're the expert. Yeah, a lot of shellfish actually can have higher levels of purine. But shrimp is the number one. Herring, tuna, mackerel, sardines, anchovies are bad if you're eating sardines and anchovies in 2023. You deserve to get gout.

Now, does anybody know what the best alternative for fish eaters? Scott knows the answer to this. The best alternative fish eaters? Tofu. Well, okay. Yes, but I mean as fish. Which fish would be the best if you were going to eat fish? Oh, salmon.

Yes, there you go. Give thyself a bell. There you go. Are we even? People with gout should eat fish no more than twice a week, however. Now, Scott should get another bell for this because he mentioned this wild game, high in purines and is really problematic. Rabbit, venison, quail.

Well, it didn't because he answered it at the wrong time. It's okay. It's okay. I have no bells. That's okay. Get used to it, sister. They'll all be coming this way. Scallops are bad

Organ meats Why are you eating organ meats? I don't know Yeah but I would tell Ray Make sure he stays hydrated Make sure he stays very active And doesn't You know gain a lot of weight

You know weight does add to things And if you're drinking beer Stop it And drink something else Skip alcohol whenever possible But you can have It says here An occasional glass of wine

Boo So, Scott, I've seen you drink beer. Do you chants it with beer? He owned a beer store. Yeah, very, very, very, very limited beer nowadays. It's probably why we don't own a beer store anymore. So what do you, what do you drink? Anything or?

Do you drink anything? Yes, you know, like like any kind of smart person I'd change from, you know, beer to tequila. Oh. Oh, yeah, you know. Yeah, that's what you do. Or vodka. Vodka. Anything like that.

Okay. What I'll do is just I will have maybe one or two drinks, but that's about it. Okay. Yeah, because anything can flare out. Even vodka and tequila? Occasionally, yeah. Okay. And Sean is demanding that he gets part of my belt to since he did say the wild game.

Okay. Yeah, yeah, yeah. So I know it hurts you. I know you wouldn't want to do it. I mean, anything that would cause it. What about vegetables? So you should eat a diet rich in vegetables, but there are some to avoid. There's something, you know, they say, but in my experience, and I've seen a little bit of research on the, the vegetables don't tend to have near the effect as the, yes.

But like asparagus, they say, can cause a... It's nasty anyway. Yeah, asparagus. Shut up. Suck it. Tacey, you've got any ideas on vegetables or Carissa? No. Many.

God. But what else is dazzling? This is the normal occurrence here. This is for myself. Man, you are one pathetic loser. That's for me. So, yeah, mushrooms, peas, spinach, and cauliflower. All the things I love, of course.

I know, I would be screwed. Oh, my gosh. It's awful. Yeah, except for me. But it's better than, it's better than gout, I can promise you that, man. Yeah, I know it is. I've seen you with it. All right.

And then the fruits that really don't matter because it's like dates and prunes and shit like that. But plums and pears are on that list as well, so that kind of sucks. Those are yummy. High fructose corn syrup stuff, you know, so you really do need a little off. They did say that. The beverages that have. Although, okay, let's, for one second, let's review high fructose corn syrup. So table salt is sucrose, right?

What is sucrose? Table sugar. Would I say table salt? That's okay. You know what you mean. Just out of those bank a chair. Yeah, that's good. Well, that's because you're an idiot.

So table sugar is a disaccharide, right? Everybody remember this from chemistry? No. Comprised of two different sugar molecules. Does anybody know what they are? Die in saccharide. Shit. No.

Take a bell. I'm taking a bell away. No. No. You see? You see? You see? You're stupid minds. Stupid.

Stupid. I might erase glucose and fructose. Fuck, yes, there you go. Give myself a... Okay, everybody's getting sick of the bells, but yes, that was correct.

It's glucose and fructose. So table sugar is what? It's what percentage of table sugar is fructose? At least 50%. Yes, it is exactly 50%. So high fructose corn syrup is anything that's more than that. Sometimes it's like 51, 52%. Okay.

So people who get all high fluid, the problem is sugar. It's not high fructose corn syrup. It's not, you know, unless it's really high. You know, fructose can be a problem by itself for some people, but it's just sugar in general. Right. That's very nice amounts of sugar. Yeah. High fat dairy products are another one and those kinds of things.

Now, Ray is pretty thin, so this won't apply to him, but weight loss can also help with that. And Scott's thin. So that one's kind of a bullshit one. but I guess if you're a, you know, if you're a big and then you're having these kinds of problems. I know it sucks. All right. Okay, doke. All right.

And Ray can reach out to me any time to, you know, and we can discuss this further. Yeah. All right. I got anything else from the fluid family? Yeah, somebody, let me go back here just a bit. By the way, if you don't know what the fluid family is, that it's the name they gave themselves. of folks who are in the waiting room which is basically our YouTube channel chat

and just watch subscribe to our channel and when we are live we don't make a big deal out of the video aspect of our broadcast because we're really a radio show but if you'd like to join us while we're recording then you're more than welcome to and every you know they seem to have a good time over there

more fun than I'm having Dennis Dunn heard you mention what you're taking the prescription medicine for your energy in the afternoon. Okay. And he was wondering if you take it every day, is it a bad thing? Can you get addicted to it? You're talking about modafinil? Yeah. Okay.

So I'm on three different ones, and I just tried a fourth one today. So I have narcolepsy or, you know, I have excessive daytime sleepiness, which is one thing, but I also have narcolepsy, which is just basically where my brain is trying to kill me when I'm driving down the road and all of a sudden it's trying to make me fall asleep. It's like, dude, why? Why? Yeah, it makes no sense. You know, if I die, you die too.

Mm-hmm. You know? And when you're driving down the road and you're using your eyebrows to keep your your eyes open and it's like, this shit? I mean, what? You know, and my eyes are fluttering up and down and, you know, I have to pull over and... It scares me.

It scares you. It scares me, then you're not going to... You'd be fine. But anyway... I would not. So I'm on three... I tried three different medications. I'm on...

I've got modafanil, R. Modafinil, which is new vigil. Modafinil, which is pro-vigil. And then Sonosi, which is the newest one. And I can't remember the generic. And then today, I tried fatigue reprieve. And I'll be honest with you, Dr. Scott stupid fatigue reprieve worked as good as any of those. It does really, yeah, I love it.

I actually take it pretty regularly. Well, yeah, you're biased. But I'm just saying, I was biased against it. But I found it to be just as a factor. I did not fall asleep on the way home. I don't know what the hell's in that shit. But it did make me kind of, I was anxious today. So I'm going to try it again and see if I get anxiety again.

I'll know that maybe, you know, an adverse effect. That's no big deal. It wasn't crushing anxiety. I don't know. Just a little bit. really, it has a little bit of ginseng and a little bit of stragglis for sure. It really does have a stragglis in it. Of course it does. Everything

long make has a stragglis in it for you. So what are these things, what was the when you created this what was the thought of putting all those things together? It was based... A little of this, a little of that. No, no, no, no, no, no. It was based on old old Chinese formula called buzongichi one. Oh, yeah, literally. Yeah. It's for

It's no middle kind of chi that doesn't come up. So it's like your energy is low. It's trying to boost your energy up. So it's boo, no, zong, center, chi. Oh, really? Yeah. And I kind of tweaked it a little bit

and added a couple things. Increased his stragglers and increased ginseng. You know, one thing that he uses in some of his traditional Chinese medicine, DNP, Carissa. No. Flying squirrel fecal matter. Yes, I do.

It's very good for you. Well, that's because you're an idiot. it's good for your stomach that's what you use that's what's what you use it for what's what I don't know I don't know I wouldn't give it to anybody that's pregnant or anything but yeah it does help someone nausea how did you find this out

you go into school yeah he did four year Chinese medical school that's why literally yeah we had it we had it in our pharmacy in a in a little glass jar it's staring with many other things fair I'm just curious who and why we first yeah why would

they look like little pills they go It looks like a pill. Like, let me just take this and see what it does. I know, I don't know. I don't know where they've got a lot of those things. Probably just didn't have much. It would be interesting to know. You just eat everything and then some of it has certain effects

and then you write it down, pass it on to the next generation. Well, you know, and I think a lot of it comes from just watching nature, watching animals. Fair. You know, they eat something and they scratch her back on something. It's like, well, maybe they're doing that because it's helping. Yeah. You know, I don't know. I don't know.

Homeopathic. I don't know, I heard that too. Homeopathic medicine. And, you know, what they used to do with those is they'd have people, they'd just line them up and they'd give them these little tidbits of things and they'd have them report what they're feeling. Well, that's a way to do. Yeah. That's a true story. So this flying squirrel feces, though, it's sterilized, right?

Yes. Okay, you don't just pick it out the squirrel's ass and pop it in some of these plants. It still smells like shit, though. Does it? Hell, yeah, once you put it in tea and pull it. Well, fatigue reprieve smells a little better. Yeah, watch it now. That's good for you. It wasn't bad.

That's good for you. It wasn't bad. It didn't have a bad taste or anything. No, shoot, no. All right. Okay, chisda, did you bring a story? No. Okay. That's a way to go, Chris.

There you go. I'm just on top of things today. No, I'm just asking. I'm not saying you should have. All right. So you guys ready to answer some questions? Yeah, let's do it. Okay.

Let's see. Number one thing. Don't take advice from some asshole on the radio. Okay. Let's do this one. Hey, Dr. Steve. Hello. I wanted to ask you, my Framingham risk for a heart attack is 1.4%.

Excellent. But my CAC score by coronary calcium. I think it is. I can't remember what it stands for. Is 113, which I think is moderate risk. So how do you wear that low risk of framing ham with the CAC score? Yeah, okay, very good. So the Framingham, we've done a bunch of times on this show for people.

You take your cholesterol and, you know, is your blood pressure elevated and do you have other issues like that? And then you mush it into a calculator and it spits out a risk score. So hers was very low. But she did a coronary artery calcium score that was deemed moderate risk. Now, remember, these things were all just screening tests. The true gold standard is cardiac catheterization, which we don't just do on people unless there's a good reason because it is very invasive. So this coronary artery calcium score is one of the stronger cardiovascular risk prediction markers, and it is through multiple comparisons, it seems to perform better across a wide range of Framingham risk categories.

you know, 6% to 10% and 10% to 20%, so 6 to 20% 10-year risk categories. But it doesn't, it hasn't been correlated with people that have an extremely low Framingham score. So it's hard to answer this question. It certainly seems to perform better among people where Framingham risk score doesn't perform well, and that is young subjects and women. So in this person, I'm going to rely more on the I'm sorry, on the calcium score. So people may say, well, what's the calcium score?

You go in and there's a CT scanner and they turn the thing on in between patients, basically, and run you through it. It's just one time through it literally takes 30 seconds to do. Any contrast or anything? Nope. Okay. And they just come up with a number.

Oh, wow. And the lower the number, the better. Cool. So when I did my first one, my number, was zero and then when I did it the second time it was like it was 200 or

150 or something like that so mine was going up but that's expected with age because I'm fucking old but anyway it's been a while since you've had that thing though hasn't a couple years talk to my primary about doing another one

because he believes in them but anyway it is a pretty good test weirdly you can get cholesterol check and your insurance will pay for that and you can get C-reactive protein which is another one and your insurance

to pay for that but most of the time won't pay for a coronary artery calcium score so I'm hoping as time goes on that those things will be covered but most places understand that mine was 50 bucks I've seen it as high as 150 but no higher than that so you just you can self-refer you can ask for it yourself I think it's good money well spent

Yeah, I agree. I agree. Now, it will not pick up soft plaques. So if you have soft plaques, which are non-calcified, you know, atheromas, then, you know, it'll show up as zero or lower than it should be. But, you know, again, screening tests, that's what they are, their screening test. And they're inherently imperfect. But excellent question, though. Very good. All right. Here's one for any of us, I think. Is there, Dr. Steve, why does one side of my nose always get stuffy, and I can't breathe out of it? Is that somebody trying to pretend that they're somebody else? I think they're trying to pretend where they're not somebody. Okay. Well, anyway, so this person has a, one side of their nose is stuffy, and the other side isn't? Anybody have any ideas on that one?

I have another question. Why is one side always runny and the other side is not? There you go. That's a corollary. Deviated septum. Give thyself a bell. Yes. You know what, though?

What if you've had your deviated septum fixed and it still does that? Yours is still doing that? Yes. Really? So one side is running and the other one isn't? That's right. Has anybody looked up your nose recently? No.

Okay. I'm not doing that again. Well, D&P, Chris, I can look up your nose and see if you've got a polyp or something in there. I probably do. I hope so. Yeah, you do. Maybe it's just your sensitive side.

Take a bell for him. No! Well, I've got somebody to do that. I could afford to give away, I guess, probably. But you, yeah, it's most likely a deviated septum. The septum is cartilaginous barrier between the two nostrils in most people if you never snorted coke

it's solid all the way back and if you have multiple times you may actually have a hole in your septum people have that or if you've had piercings that go through the septum no coke no piercings yeah no I'm just describing what the nasal septum is I have a deviated septum

do you really and you never got it fixed can you plug one side of your nose and breathe and then plug the other one so we can see if we can hear the difference like you know okay that's one side oh you have much more

flow out of that one yes okay so I would I would assume that your septum deviates to the right then see I got a free nose job with mine yeah so it was perfect you had a concha belosa which is the

and a deviated septum yeah she had all kinds of mess going out in there I was all kinds of mess going up in there but and then her guy had a her E&T had a crush on her and so he did a nose job I did not have a crush on me. He's a very nice guy.

Well, you can't blame him, can you taste? No, not really. But so, I mean, he just was like, he just lit up when I said, how much would it cost for a nose job? He was like, for you? Nothing. And I was like. Nice. Who was this?

Hell you. We'll tell you after. Maybe I need to go there. We'll tell you exactly after the show. Okay. So, yeah, so that's what that is. And just get somebody to look up there. they're severe enough, sometimes they'll do surgery on them to fix them.

And for a lot of people, that is the greatest thing that, you know, that they've ever done. It really works. I've had people come back to me saying, oh, my God, I can breathe out of both sides of the nose. For the first time ever in my life, I could breathe. It's like I could breathe a Mack truck through my nose. Like, just bring it on, I can breathe it. Yeah. That's pretty awesome.

Really. Bring on that air. I can breathe it. I mean, for the first time ever. That's awesome. If you need a question, I've got you one. Well, okay. We do.

We have one for you, but go ahead. Yeah. Well, I was going to say, Ty is asking, his wife is 47 years old, was recently diagnosed with rheumatoid arthritis. Any advice on pain management in getting her energy level up? Yeah, get it treated. Well, I was going to say, can I say the non-pharmacological. Yeah, yeah. Before she goes to methadrexates and, you know, lots of steroids and stuff.

Biologicals at these days, but, yeah, go ahead. The lot of the biologicals are wonderful. A lot of them aren't always tolerated. But before you go that route, there are some things that have been shown with herminton arthritis. Dietary changes in your microbiome and your gut health seems to make a huge difference. So if she's 47, a little, maybe a little late for it to come on, possibly, you know, I would wonder if maybe she'd had some surgery where maybe some hardware or something was implanted, I would ask. But I would double down on diet, paying attention to the foods. and that she eats and things she drinks,

making sure that anything that causes any kind of inflammation. Again, you know, my number one thing about chicken causing inflammation. You know, I eat chicken, I get inflammation. Really? Yep. And I've had, I mean, dozens of people stop eating chicken. And a lot of their arthritis goes away. Well, that's interesting.

You know, if you could pinpoint that, you know, there are people with that alpha-gal syndrome that get bit by a tick. and now they can't eat red meat, that's for real. Yeah, no, it's really. And that'd be an interesting chicken correlation. Large protein molecules. Well, you know, my mother has that. And, you know, a lot of that autoimmune stuff is hereditary, and I'm terrified of that specifically.

So I've always gone to the gym and worked out and lifted weights to kind of help prevent that. But, I mean, what would you tell people to do to prevent? that if they have like a parent or somebody who's... Well, if they have joint destruction and stuff, they've got to be careful, but... I mean, what if you don't have it? Oh, you mean for you? But you want to prevent it, yes, from...

Like if it's hereditary for you. And I would say number one, diet microbiome of your gut. Number two, huge fan of turmeric and curcumin. The natural anti-inflammatories seem to make a huge difference. And then number three, like you're saying, I mean, you spend a lot of time working out and exercising, and I think that's a huge benefit. Yeah, I'm staying active.

I'm looking at an article from Nutrients Journal. It's not some slag, you know. Mambi, Pambi Journal. And it says in recent years, increasing number of studies suggest that diet has a central role in disease, risk, and progression. Yeah. Well, since my mom eats jelly beans for breakfast. I'm on a new diet.

I just eat jelly beans all day long. One meal all day. Starts at 7, ends at 10. Yep, yeah, that was the best one when she said that, yeah, I just eat one my eel a day. You know, we went on vacation with her. And she was right. But it's exactly as Tacey said, started as soon as she got up in the morning and didn't end until she went to bed. Oh, goodness.

Just one meal. And there is a, there are some several studies that show that people, your mom's size, have a lot of difficulty of gauging how much they're actually. eating and there's ways that you can determine that and you there was a hallmark study where they took people who had a you know BMI of 40 or whatever and

they had them estimate how many calories they took in and they'd say well I ate this and I ate that and then they'd run it they'd just say what they ate and they would estimate how many calories that would be and then they did a thing called doubly labeled water and what you can do with that

is when you give someone doubly labeled water and have them piss in a cup, you can calculate from that exactly how many calories they took in the day before, and it was wildly different. Oh, yeah. They'd estimate, you know, 1,400 calories, and they'd actually be taking in 6,000 calories. So what's the normal age onset for rheumatoid arthritis? I thought it could hop on at any time, yeah, but. Because I've been waiting on it, because, you know, autoimmune disorders are really fun,

and then they're inherited, and it's just great to have, like, Hashimoto's and shit like that. Yeah, it's most likely to show up between ages 30 and 50, so. Oh, good. I got... Yeah, you got one more year to go. Another year to go. I'll say just a little like... Chris had something.

No. I thought you raised your hand. Oh, I just don't tolerate red meat. Oh, yeah, no. Really? It doesn't give you the... What does it give you the green apple? Quick step?

Pretty much. Okay. I'm looking here, it says several nutrients such as polyunsaturated fatty acids present anti-inflammatory and antioxidant properties featuring a protective role for rheumatoid arthritis development, while others such as red meat and salt have a harmful effect. Gut, microbiota, alteration, and body composition modifications are indirect mechanisms of how diet influences rheumatoid arthritis onset and progression. So Tacey, you should be taking some polyunsaturated fandy acids into your diet, which you do because that's what I cook with. But possible protective effects such as the Mediterranean diet, vitamin D, and probiotics could be a possible future adjunctive therapy

to standard rheumatoid arthritis treatment. So there you go. All right. I'm not going to give you a bell for that because I would just be giving you so many bells today. Yes. I want to know. That's I just haven't many. This is Mike from Ohio. What? Will you please give Dr. Scott a minute or two on your show to share the highlights of his badass baseball career? Oh, it won't take a minute. All right.

Well, here's how much time we're going to give Dr. Scott to talk about his badass baseball career. Hey, Dr. Steve. Exactly. Can you explain that? Thank you very much, guys. I'd like to hear it. No, hell no. Alzheimer's, I don't know if I pronounce that right, but Alzheimer's.

Alzheimer's and dementia, please, and thank you. Yeah, sure. It's very simple. Those are the first of the questions, Steve. He just wants to know the difference between Alzheimer's and dementia. So all Alzheimer's are dementias, but not all dementias are Alzheimer's. That's the best way I can talk about it. Chris, you're nodding your head.

Can you list some of the other dementias I'm putting you on the spot? Vascular. There you go. See, I just want to give you a bell See, nobody walks out of it or not a bell Yeah, so you got vascular I mean, I am a geriatric nurse practitioner I should probably be able to just name them all

Beginner's luck, beginner's luck Well, what else we got? One of the kinds of dementia we got Parkinson's Yeah, Lewy body dementia, very good Yeah Oh yeah Give thyself a bell

She's going to kick her ass No, no, no, I'll weigh up I've got like 12 today No, you don't. That is so full of shit. I'm going to take the fucking Bail's the whole show is going to be about Bells. All right.

Yeah, so Louis Body dementia, there's a bunch of other fronto-temporal dementia. Alcoholic. Oh, yeah. Oh, yeah. Of course, Wernicke-Korsock-Sindrome. One of our friends from the old radio show suffers from Wernicke-Korsov and she thinks that she is

currently in the Navy. Oh, goodness sakes. on a naval ship, but she's in the, you know, nursing home. There you go. Well, she's happy anyway, so that's something. All right, my friends. Before we go, let's do, I think we've got one more here. Let's see.

Hey, Dr. Steve. I know you have done this before, but could we please revisit the use of these diabetes drugs when it comes to weight loss. I am 54. I am not quite menopausea yet. and struggling in everybody, I know. And I can name you at least five people. Well, thank you.

Our own drugs and having great success, it just makes me nervous. And what are your thoughts on this for someone like me? And if so, if you think that's an option or something I should pursue, how do you go about talking to your primary without sounding like a bandwagon jumper? Oh, no. Thank you so much. and you are still appreciated. Oh, thank you.

So let's talk very quickly. Let me set the stage and then you guys, because half of the people in this room have tried these drugs. There's this class of type 2 diabetes drugs that improves blood sugar control, but actually it leads to weight loss. And they're called a glucagon-like peptide-1 agonists. And there are these other ones that lead to weight loss,

improve blood sugar, or SGL. So, you know, the S-G-L-T-2 inhibitors, Tacey, those are the ones that have been shown to increase the risk of fornia gangrene. Is that right? It's the G-L-Ps or the, you know, are the ones that they're advertising right now, right? Okay, so all I know about is Ozympic and Manjaro. Okay, but you used to... They're G-L-P-1s. Right, that's right.

Okay, so let's talk about the GLP ones because that's where all the interest is right now. That's where all the interest is right now. So these are the ones that end with tide. Yeah, they're semi-glutide, and then the Manjaro one, I'm not sure what is. Well, Bietta is Exanatide, and then Trulicity is Dula Glutide and et cetera, et cetera. But Ozempic. And Manjaro is Therzipatide, and I think that's very important. Okay, very good.

The difference between those. Yes, absolutely. So these drugs sort of mimic this action of a hormone called glucagon like peptide 1. And after you eat and blood sugars start to rise, these stimulate the body to produce more insulin, and that extra insulin lowers blood sugar levels. And it's not really clear how they lead to weight loss, except that you guys are going to talk about this it has some sort of add you know all drugs just have they have a whole bunch of

effects none of them are side effects they're just effect some of them are positive some of them are negative and so it has other effects other than this so go ahead taste you started in slow slows gastric emptying yeah so makes you feel full or faster there you go it makes you feel like you're going walmick sometimes if you if you overdo it And if you're a naughty girl or boy. Yeah. So now you've done the tersephotide. And DNP, Carissa, you said that you had done the semi-glutide.

Is that right? Correct. I'm doing it currently. Oh, you're currently doing it. So tell us the, tell us how it's working for you and what kind of effects lead to the weight loss for you. So I've been using it since. the fall sometime. Okay.

Since that time, I've lost approximately 50 pounds. Wow. There to go. And... You're going to waste weight to nothing. No. The biggest thing really is probably the slowed gastric emptying because I... I'm a person who can, like, bored eat.

I mean, if I'm, like, bored, I could just eat, and I can't do that anymore. Yeah. And I don't crave sweets. I have a huge sweet tooth. I could have lived on sweets before Ozimic, and for whatever reason, now I have to really want something sweet, and it's completely different sweets that I want. So I don't know if that's related or if that's just some weird shit from COVID still or what, but the day after I take my injections, so I do an injection once a week. and the day after I have terrible reflux and nausea to the point I usually don't eat it all that day, which is a terrible habit, not advocating for that.

But that's the only day I have side effects. Otherwise, I don't have any constipation, no diarrhea. I don't have any of those. However, I do know people who have struggled with both constipation and diarrhea from those medicines. Well, the reflux makes sense. If you're delaying gastric emptying, you've just got built up of stomach contents, and it's hitting your lower esophageal sphincter. And so, like, by the end of the week, after my injection, I can, I guess, tell it's wearing off because I'll usually eat like shit that day. And then the next day I take the shot, and then the next day I'm dying from heartburn.

So, I mean, it's kind of a vicious cycle that I do to myself. Yeah, yeah. But obviously successful. Yeah. Well done. know if your family has a history of thyroid disease. Yep. Yeah, have you ever researched the thyroid

connection with these things? Because they all the ads are all, well, if you have multiple endocrineoplasia, and I wonder what the connection is. That, I do not know. We should probably look that up. Yes. We should look that up. But not right now. You know, I've asked you that a thousand times. Yeah. And it just

says that it never says anything about Hashimoto's, which I have. And I've taken Manjaro and of Zimpic. I'm taking Ozimic right now. I just started it this week. But the problem with those two medications right now are it's such a big thing for people to take it for weight loss that the diabetics can't get it, which is causing a shortage. And that's causing trouble for people who want to lose weight. They just need to make more. They just can't make enough. And so my insurance actually

denied. I'm on my last Ozempic. My insurance actually denied it for next time. But I have PCOS, so I have an insulin resistance issue. Right. Which is going to cause me some trouble because I've been on these medications

for years. And what now? I'm just going to let my insulin resistance just go wild, go crazy. I mean, I do worry about that. What do they want you to take instead? Well, they haven't said anything. and my physician's nurse doesn't know how to do

a prior all three buttals. Oh, I can help you with that. I've got to go see him and let him know that there's an issue. My insurance didn't cover it at all. I just paid out of pocket for it. It is so expensive. Literally one pen, which would last a month, could range like $700 to $1,000.

Well, you can get it. Do you know you can get it? There are metaspaws. You know about that, I'm sure. And so I have friends that... Well, I'll finish that sentence. You know there are metaspas. Work at these metaspaws that are having it compounded.

Oh. And so it's much cheaper. It's like... I can't remember how much they said for the OZemPEC, but for the Manjaro, which I had no side effects on and lost 20 pounds, you know, without... blinking and I is 300 a month.

So you've got to decide. And, I mean, that's a tough decision, especially if you kind of need it. You know what? Are they waiting for me to become a diabetic so that I can get it? Right. Because I can help them along with that.

Well, and I have all the risk factors. I mean, PCOS. You have PCOS? You do? Oh, well, you should be able to get that approved. Correct. You would think so. Because of polycystic ovary syndrome is a disease of glucose intolerance.

They need to diagnose it as glucose intolerance slash pre-diabetes, and you can get it. And that's not a lie. They're just coding it wrong. Yeah. But, I mean, I'm at my out-of-pocket deductible, and now it's like $60 a month. Okay, well, then. All right. Never mind.

But not everybody can do that, though. No, it is ridiculous. It is ridiculous. I have to go through that. Yeah. I was looking here. Here's a meta-analysis, which is where they take a bunch of studies and mush them all together to get more data so that you get more sensitive answers. And these are all randomized controlled trials, and they were looking at GLP-1 receptor agonists, like what we're talking about, and the occurrence of thyroid disorders.

And what they found was GLP-1 receptor agonists did not increase or decrease the risk of thyroid cancer. hyperthyroidism, hypothyroidism, thyroiditis, thyroid mass, or goiter. But they said due to the low incidence of these diseases, the findings need to be examined further. So this isn't conclusive, but it should make people feel a little bit better about it. And particularly if you don't have thyroid disease, but you've got family history and you're worried about it. Well, so, Steve, if you've got a family history of autoimmune diseases. Right. Correct?

Yes. aren't you more prone to like um it depends on what they are Hashimoto's well um you know risk factors for autoimmune diseases include some medications have obviously having relatives with autoimmune diseases smoking people if you already have one autoimmune disease you're more likely to get another one being female 78 percent of people who have autoimmune people who have autoimmune diseases smoking people who have autoimmune disease you're more likely to get another one being female 78% of people who have autoimmune diseases are female and being overweight. So I know. Yeah, I know you guys get screwed on everything. All them periods and tits and stuff.

So anyway, but yeah, so now as far as PCOS, my, you know, let's look up risk factors for PCOS. And see if it's genetic. I would say that it almost has to be. Yes. But type 1D diabetes, type 2 diabetes, well, no kidding, gestational diabetes, insulin resistance.

Yeah, well, okay, these aren't really risk factors. Those are concomitant illnesses, but, yeah, pretty much, okay, let's look here under Mayo Clinic. This is always, this is the place I like to go, symptoms and causes under Mayo Clinic. And, yeah, they're completely unrevealing. So, you know, as far as risk factors are concerned, is it a cause? cause that people with PCOS are overweight, or is it an effect? And I always thought it was hereditary from a parent who's diabetic. That's what I always thought.

There is gene sequencing and an association between autoimmune diseases, such as lupus, Hashimoto. Really? I mean, I'm just reading an article. That's okay. That's all I'm doing, because she just dumped me on this one. You stump the chump. Stubbed the chum.

Basically, there needs to be more research because there's fluctuating levels of auto-antibodies in different PCOS patients. That's interesting. Because I was then when I was diagnosed with PCOS, I got off birth control because we were going to try to get pregnant. I gained 50 pounds in like five months. Same. I can't take birth control, and that's when my weight went out the roof. And that's when they figured out I had PCOS. Yes.

If it is autoimmune, if there's an autoimmune factor, there may be different treatment options that could help with that. Oh, interesting. All right. Well, to be determined in the future. All right. Well, listen, everybody, thank you for being here. Thanks, Dr. Scott. Thanks, Tacey.

Thanks, DNP, Carissa. And thanks to everyone who's made this show happen over the years. Listen to our Sirius XM show on the Faction Talk channel. Cirrus XM Channel 103, Saturdays at 7 p.m. Eastern, Sunday at 6 p.m. Eastern, on demand, and other times, the Jim McClure's pleasure. Many thanks to our listeners whose voicemail and topic ideas make this job very easy. Go to our website at Dr. Steve.com for schedules, podcasts, and other crap. Until next time, check your stupid nuts for lumps, quit smoking, get off your asses and get some exercise. We'll see you in one week for the next edition of Weird Medicine.

Goodbye, everyone. See, guys. You know, I'm going to be able to be. I'm going to Thank you.