Weird Medicine: The Podcast - 567 - HPV Neck Tee Shirt

Episode Date: November 23, 2023

Dr Steve, Dr Scott, and Tacie discuss: Pig Kidneys NAD+ IV Therapy diet drinks and libido or something weird anatomy papilloma virus on your junkal region sciatica and gabapentin retinal detachment Please visit: stuff.doctorsteve.com (for all your online shopping needs!) ed.doctorsteve.com (for your discount on the Phoenix device for erectile dysfunction) simplyherbals.net/cbd-sinus-rinse (the best he's ever made. Seriously.) RIGHT NOW GET A NEW DISCOUNT ON THE ROADIE 3 ROBOTIC TUNER! roadie.doctorsteve.com (the greatest gift for a guitarist or bassist! The robotic tuner!) see it here: stuff.doctorsteve.com/#roadie Also don't forget: Cameo.com/weirdmedicine (Book your old pal right now because he's cheap! "FLUID!") Most importantly! CHECK US OUT ON PATREON!  ALL NEW CONTENT! Robert Kelly, Mark Normand, the O&A Troika, Joe DeRosa, Pete Davidson, Geno Bisconte. Stuff you will never hear on the main show ;-) PLEASE NOTE: we have completed negotiations with Studio 71 and should start anew next week! Learn more about your ad choices. Visit podcastchoices.com/adchoices

You are one pathetic loser. I am too smart. I am too smart. I am too smart. I am to smart. I am too smart. You see? You see? You're stupid minds. Stupid. Stupid. If you just read the bio for Dr. Steve, host of Weird Medicine on Sirius XM 103 and made popular by two really comedy. shows, Opie and Anthony and Ron and Fez, you would have thought that this guy was a bit of, you know, a clown. Why can't you give me

the respect that I'm entitled to? I've got diphtheria crushing my esophagus. I've got Ebola spripping from my nose. I've got the leprosy of the heartbound, exacerbating my infectable woes. I want to take my brain now, blasted with

the wave, an ultrasonic, ecographic, and a pulsating shave. I want a magic pill. Oh, my ailments, the health equivalent of citizen cane. And if I don't get it now in the tablet, I think I'm doing, then I'll have to go insane. I want a requiem for my disease. So I'm paging Dr. Steve. Dr. Steve. I'm the world-famous Cardiff Electric Network Studios.

It's weird medicine, the first and still only on a censored medical show. In the history of broadcast radio, now a podcast. I'm Dr. Steve with my little pal. Dr. Scott, the traditional Chinese medicine provider, gives me street cred to whack alternative medicine assholes. Hello, Dr. Scott. Hey, Dr. Steve. And my wife, Tacey, my partner in all things, hello, Tacey. Hello.

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While I'm on my wellness retreat, I'm going to maybe think about doing a Patreon every night. Nope. Why not? Because that's not a wellness retreat. Yes, it is. No. No, it isn't. Why isn't it?

No devices. Fuck off. Except for when your wife calls about the fucking internet. Fuck both of you. Eat my ass. It's either you or Scott. Oh, you're not supposed to curse in the last first two minutes of your show without getting... Well, you did it.

Oh, I did it. You made me. And check out cameo.com slash weird medicine. I will do cameos from there because that's relaxing. I will do cameo. So, cameo.com slash weird medicine. Five bucks. Please send tasty money.

It's half of what, too. Because I've got to eat. Yeah, it's half of what toky charts. And I'm going to have to. Oh, yeah. You're going to cry for it now. Go, go, go. What do you call it, DoorDash and shit?

Yeah. That's her. Poor old taste. Does he'll taste her. Poor old taste. And what if the Wi-Fi goes out? Well, then you're just crazy. Oh, for fuck's sake. Yeah, and you're screwed.

Well, anyway. Screwed girl. This is what I'm going to be doing the whole time. I love a master page. Yeah. I hope you get your money's worth. Yes. All right.

Very good. Check out Dr. Scott's website at simplyerbils.net. That's simplyerbils.net. Everything going okay over there. Oh, yeah. We are recording this in September 12th, as a matter of fact, of 2023, and it is officially allergy season. There's grasses and ragweed and stupid crap out there. And, you know, check out Dr. Scott's website.

He's got a possible solution for you. I can't actually – whoa, nice. That was my fault. Can't actually advertise anything on here. But check out Dr. Scott's website at simplyherbils.net. Maybe you'll say a thing. to the Mott Hey, Bing, Vikings. Anyway, all right.

Last time, we did kind of a fun thing. I think it was fun. We went back to voicemails that we've never answered from 2014 and found out that people had some shit going on 10 years ago that we never got to, so hopefully they're okay. Maybe we'll get some feedback. So I thought we'd do some more of that today. But before that, I think it is time for... It's Tacey's Time of Topics, a time for Tacey to discuss topics of the day.

Not to be confused with Topic Time with Harrison Young, which is copyrighted by Harrison Young and Area 58 Public Access. And now, here's Tacey. Tacey wishes she was on a show called Tacey in Paris. Yeah, Tacey in Paris or Tacey in a room that has air conditioning. Hello, everyone. You know, we're trying to work on that. We're going to move the studio, but then Tacey was like, no, I like it up in, you know, and it's like, okay. Well, okay, nobody turned the air condition on, so that's not an fair argument.

Okay, so topic one, hello everyone. Scientists grow human kidneys inside pigs using stem cells. Oh, yeah. A team of Chinese researchers has successfully grown early stage developing human kidneys into female pigs. pigs using chimeric embryos. Yeah. This is the first time. True chimeric embryos?

I mean, are they chimeric in the sense that they're half pig, half human? Well, if I can read on. Oh. This is the first time a solid human organ has been grown inside an animal species other than human. Yes. And this was in interesting engineering. This is also from Stacey, what's his face. Okay.

Unlike normal embryos, chimer. American embryos contain cells or tissues from two different organisms. And what are the two organisms? In this case, the researchers used human and pig cells. Wow. So these are true hybrids? Sounds like an ex-file. I mean, I reckon so.

Oh, my God. They're going to be overrun by pigmen. Or man pigs. So we already have those. The researchers claim that the embryos underwent normal development inside pigs for 28. days during this period, they noticed the formation of tubules and some other renal structures in the developing kidney. What?

The study demonstrates proof of principle of the possibility of producing a humanized organ. Okay, so they just, okay, so they have, the pigs are chimeric or the embryos were chimeric. Well, I was kind of, the embryos were I mean, the pigs were chimed are. So the pigs are raised with human and pig DNA. I'll temporize

while you look for that. I'm not looking for it. Oh, you're just looking. I'm just looking down. I'm just reading. I'm just very curious because, so they just raised some embryos and saw that the embryos made kidney tubules and then just what, aborted them.

You know, the question I was going to ask you, Steve, is what a chimeric pig is. So you cannot ask me any questions beyond that. Yeah, no, no. Okay, so while you said it, chimera are, you know, in mythology, it was a mixture of two different animals, right? It would be like, what, but had wings and a lion with a man in a unicorn or something? It says the researcher used human and pig cells to create the chimeric. embryos. So it was a mixture of both. Oh, boy. Yeah, there's a whole thing about moral uncertainty and the farming of human pig

chimeras. So this is from National Library of Medicine. This is from the Journal of Medical Ethics in 2019. They were worried about this. They said it may soon be possible to generate human organs inside of human pig chimeras via a process called interspecies black astocystic complementation. Well, let me continue reading. Oh, there's more. And you can comment as you feel obliged. In the past, scientists have used a similar process to produce human tissue and muscles inside pigs.

However, they couldn't grow an entire organ because successfully incorporating human stem cells with pig cells is very tricky. For instance, pig cells tend to be more successful or dominant in such. embryos because they multiply more rapidly than human cells. This competition can make it challenging for the human cells to survive and develop within the pig embryo. Wow. Also, human and pig cells require different nutrients, environmental conditions, or signaling molecules to grow.

So they employed three techniques to overcome these challenges. First, they used CRISPR to eliminate. eliminate two genes, two genes and pig cells. CRISPR is basically a gene editing system. That's required for pig kidney development. This ensured the growth following human kidneys. Second, they insured and used human... Well, you know, if you cook...

Pluripotent stem cells in the chimeric embryo. Bacon and lard, it'll make it hit crisper. These cells can renew growth and divide into any type of. of human cells. Third, they created an optimized environment for the embryo to accommodate the distinct needs of both human and pig cells. This environment ensured that each cell could receive the nutrients and molecules best suited for their growth.

They must have had plenty of mud and I heard accommodate them pig cells, don't you know. Okay, so they created 1,820 chimeric embryos. Right. So the mother is an act. actual pig. The embryo is chimeric, which makes me feel a little bit better that they don't actually have adult pig human chimera running around.

And they only use 13 surrogate pig mothers. And they only examine five embryos. You bunch of pig mothers! That's what they called them. I know. When they examined five embryos after 28 days, they found that they had grown into mesonifros, Early-stage human kidneys with tubules and cell gross forming the ureter.

Okay, so the thing is that where the ethics is going to come into this is because they're going to make embryos inside these surrogate pig moms, and they have some human DNA and some pig DNA. First off, if you grow one all the way to the end, I don't think it will grow. No. I think that something, what Tacey was alluding to is that, you know, the pig cells want to develop faster because pig embryos develop faster than human embryos. I mean, we take nine months to develop. What's the gestation period for a pig? Do anybody know? Nope.

Okay, well, let's ask, let's see if echo. I know it's like five weeks for a Labradoodle. Pretty quick, yeah, that's pretty quick. Echo, what is the gestation period for a pig? Here is an answer from an Alexa Answers contributor that I translated. The gestation period for a pig is 114 days on average. Well, that's longer than I thought. So it's about, I don't know, so 14 days.

Four months? Is that right? Yeah, right, right. Something like that. Yeah, because 120 days would be four months, right? So about, so they, it develops about twice as fast. So those cells will overtake the human cells. That's probably a good thing because you don't want to deliver one of these things.

because God knows I mean I've seen I am legend and other movies like that or Alien 3 where the alien came from a dog Oh goodness

But and then the other thing is Is that are some people going to say Oh well This is you know Human and you're killing it And it's like no You should see this as an abomination And therefore

Okay to kill and harvest It's organs you know, those people, you know, who I'm talking about. So I think, yeah, this is very, very interesting. It really would be better if we could just grow human kidneys in the lab, you know, just in a vat, that way, artificial blood supply and grow them that way. But I guess that's a long way off. You know, we just don't have the way to 3D print them.

then animate them. You know, if you could 3D print the tissue scaffolding and then populate it with stem cells that you didn't harvest from a fetus because that's where everybody freaks out, we can create stem cells without using fetal cells now. So, and then have them go in and somehow figure out how to make the tubules and make a functioning and kidney, that would be the greatest thing, because then we wouldn't have to worry about organ donation, people with brain-dead children wouldn't be, you know, having to talk to the organ-donation people about, you know, harvesting organs and stuff like that.

I think organ donation is a really noble thing, and we should all say yes to that, but it is always born from tragedy. It's some brain death or a brain-dead person. is really the only ones that can donate live organs, either that or a thing called donation after cardiac death. And what that is is where you take the person into the operating room, while they're still, quote, unquote, alive. They haven't quite become brain dead yet. And then you wait until they die. And then someone pronounces them.

And then they revive them enough so that they can get the organs out in one piece. And, I mean, the whole process, I think everyone, including the donor services, would say, yes, we would prefer it if we could just pull these things off the shelf. Yes. And we'll have it someday. This is another step in that direction. Mm-hmm. You got anything else on that? That's really interesting.

I do not have anything else in that, but I do have a topic two. Topic number two. Yay. After treatment with Simoglutod, people with newly diagnosed type 1 diabetes need to be a topic. needed little or no insulin. What? And people with diabetes, there are issues with how the body turns food into energy.

This is just a little background. Yeah, no, thank you. I know. Insulin? Insulin. Oh, good. Uh-oh. So you're fine.

Keep going. Which is released by the pancreas to regulate how the body cells turn blood into sugar. Damn, that was spam. I should have answered it. Is either ineffective or produced in insufficient quantities in a person with diabetes. There are three types. Type 1, you can get it at any age and is treated with injectable insulin. Type 2, prevented through lifestyle changes and responds to semaglutides and gestational diabetes,

which develops in some pregnant women. Type 1 has been treated with insulin injections ever since insulin was first isolated in a lab in 1921. It is effective, but it requires daily treatment in order to be effective. Semi-glutides are effective at treating type 2 diabetes along with providing weight loss management, which is through all the rage now, and you can't get it anymore. If you are not diabetic, and if you are getting it, please email Steve. Oh, yeah. And I'll just keep your mouth. They haven't typically been prescribed to treat type 1 diabetes.

Right. As a matter of fact, there's always a warning that says this is not for treatment in type 1 diabetes. So I don't know if you're going to find that this is... No, I think this is really interesting. Well, it is interesting, but I don't know if it's a legitimate study for you. What do mean? Yeah. It does come from medical news today, though. Well, that's not where the study was. It was New England Journal of Medicine. That's where I got the information from. Thank you very much.

Dr. Parish Dandona, the study's senior author and a professor of the Department of Medicine and former chief of the division of endocrinology. Jacob School of Medicine. I felt it was important to say his, you know, what he was. Told medical news today that researchers wanted to explore how people with type 1 diabetes responded to simiglutide. Do they know how this works? Because this is outstanding. Now, what I've got, this is in the New England Journal, but it's correspondence.

So it was a small case series, semi-glutide after the diagnosis of type 1 diabetes, which is insulin-dependent diabetes. led to elimination of insulin with meals in all patients and basal insulin, in other words, where they give themselves the long-acting insulin, in most, along with improved glycemic control. What in the hell? Yeah, because people believe that there is no insulin reserve in a patient with top one. Obviously incorrect, if this is true. And that's how it's been practiced since 1922, maybe time for a change.

We discovered about four years ago from other studies that all new diagnosed cases of type 1 diabetes have 50% of their insulin reserves still intact. The study was composed of here, want, want, 10 people, all of whom had been diagnosed with type 1 diabetes in the past three to six months. This is basically a proof of concept study. Over a period of time, their semi-glutide dosage was steadily increased as they were weaned off their usual insulin. shots. Within three months, researchers reported none of the participants required miltime insulin doses, and within six months, seven of the ten participants no longer needed basal background insulin. Right. Okay, so this is what, if I had a kid, and they had, were diagnosed with type one diabetes yesterday, I would absolutely get.

get them into a study. I'm looking it up on clinical trials.gov right now, semi-glutide and type 1 diabetes, and we'll do all studies. This is, okay, there are quite a few places that are recruiting right now. Type 1 diabetes impacts of semi-glutide on cardiovascular outcomes. Adjunct semi-glutide treatment in type 1. Randomized trial of semaglutide for diabetes. kidney disease in type 1, we want to find the one where your weekly subcutaneous

semaglutitis, adjunct to closed loop therapy in type 1 diabetes. There's a bunch of studies, a matter of 21 studies that are active on clinical trials.gov. So what you do is you talk to your endocrinologist, bring that thing in and say, I want to try this. Yes, yeah. And if they need to get them into a clinical trial, I would absolutely do that. This is stunning enough that it's worth pursuing, even though we don't have double-blind placebo-controlled data. We don't have a sufficient number of people who have been in these trials. But if you can turn this around for a kid, then you don't end up with PA John, who has had diabetes type 1, his whole life, on an insulin pump.

and is, you know, at risk for heart attack, stroke, kidney disease, retinal disease. Your dad was another one. Now, your dad was a little different. He was type 2 who turned into a type 1. He went so long that he ended up having to have insulin, even though he was type 2 diabetic, and we became insulin dependent. So there's more information here on understanding semi-glutas. This is outstanding.

Yeah, go ahead. And how these medications are not only helpful with people tattooed. diabetes but also aiding in weight loss. However, the weight loss is more concentrated in lean muscle rather than fat. So it's very important for all these people who are still getting it. Listen here. To counsel them on strength training, weight training, and regularly exercising because otherwise you're going to get skinny fat. Skinny fat is no good. Once you lose weight, up to 40% of that could be muscle. loss, and that's very hard to get back, especially as you get older.

That's wild. So they talk about how semi-glutide is currently only approved for type 2 diabetes, and therefore... And every ad you see, they will say, not for use in type 1 diabetes. Yes, and not covered by insurance companies for type 1 diabetes. But if you can get into clinical trial, they'll pay for it. But it could represent a big change in quality of life for patients with type 1. Wouldn't it be wonderful? Instead of three shots a day, you get one shot away.

We've been looking for a stem cell transplant for type 1 diabetics for all this time trying to figure out a way that we can just get their pancreases to make insulin again or an artificial pancreas, you know, all this thing. Wouldn't it be wild if just this drug and all you've got to do is just give it to them early enough and they never have to, whatever the process was that was killing the, as Dr. Scott calls them, islet cells. We in the United States call them is it. I let cells. Whatever is killing those. This stuff actually just stops it and then they regenerate. It would be wild if they could produce enough for the people who need it right now. True. So I know it sounds like science fiction but they're going to expand the study to make a multi-center study for a

prolonged period of time. Yeah, because you don't want it to be a flowers for alderan type situation where they're okay and then all of a sudden they regress again. So that concludes Tacey's topics. Well, I'm going to give you a bell for that. I'm a bell. That was a good one.

I'm excited about that. I don't get excited about too much of this shit, but that's very excited. That is pretty awesome. I've had so many adolescents that just go, fuck it. I'm not doing this, you know, because that's what adolescents do. And it's like, listen, just hang in there, hang in there. It's coming. It's coming.

And, you know, I kind of feel like I gave a few of them a bum answer because some of that was 30 years ago and we're still searching for the answer. But it was always right around the corner. This is really, really interesting if this bears fruit. Now, again, we're talking 10 people, stunning result, unheard of, unprecedented result in those 10 people. But we've got to do this right, you know? Yeah. So standard treatment, we don't have to do placebo necessarily. That may be with something that's this stunning of a result, placebo control may not be ethical.

So they'll have to decide that. But, you know, if this holds up, they'll have to stop the study, switch everybody over to the treatment phase. If they do a placebo control, I don't think they will. They might test them against historical controls because everybody knows how it goes. You don't really, with type 1 diabetes, we all kind of know how it goes. You know, these kids present with diabetic ketoacidosis, which is the first time that their pancreas fails and their blood sugar goes crazy. They can't absorb or I'm sorry, they can't incorporate sugar into their cells anymore. So they start to burn fat.

That's why they get the ketones. And they get sicker in hell because their blood sugar just keeps going up and their electrolytes get messed up and stuff. And then you get them under control with an insulin drip, and you send them home on insulin, and then they start sticking their finger and all this stuff. You get them on an insulin pump eventually, and eventually, you know, although the outcomes are way better now than they were, they end up with complications, et cetera, et cetera. So we all know that's how this goes. We don't really have to do a placebo control, in my opinion, for this particular condition,

because we've been dealing with it for 100 years like this. So, you know, using matched historical controls, I think, would be okay. Now, if you want to do it in older people and see if it prevents heart attack and stuff, then I think it's totally fine to use, you know, placebo control because we don't know if it does anything there. But anyway, anyway, this is, yeah, I'll shut up about it. I'm very excited. All right.

We had a question about NAD. Is that what it was? Johnny Long, something or other? Longfellor. He's one of them long failers, I tell you. It's see. Dr. Steve, about the NAD infusions. Maybe you can talk about that a little bit.

Okay. Okay. Yeah, I know a little bit about nicotinamide. So, NAD is nicotinamide adinine dinucleotide. And there is some data that shows that you can preserve of cognitive ability, executive functioning through supplementation with NAD precursors. And the one that I take is nicotinamide riboside. Now, Scott, weren't you taking a nicotinamide at one point?

Yes, I still do. You still do? Are you taking the nicotinamide riboside or what are you taking? Nicotinibate riboside, yes. Okay. Yeah, yeah, I am. You can take niacin, but, you know, that stuff, you get the red face. Hootty-hoo flushes.

and Green Apple Quick Step and all that stuff. But, yeah, so NAD may have some benefit in age-related cognitive decline. Maybe even there's some data, but, you know, looking at Alzheimer's dementia and vascular dementia. But there's also some data on diabetes stroke and traumatic brain injury. So it is very interesting. I know that some places are setting up NAD. infusions. I'm not aware of data that shows that getting one infusion every month is superior to just taking nicotinamide in a pill form. And I don't have some, do you have any?

No, but I was going to say in there, I also see whether they use it sometimes for drug and alcohol addiction to help with withdrawal symptoms. Yeah, but I think the reason, it's obvious, well, I would assume the reason they do with IV is just so it's a lot quicker to the brain, maybe bypasses the blood brain barrier, unlike a pill. Maybe? I don't know about that. Or maybe because it's more expensive to do an IV therapy than this, to do a oral, than to do a pill at home. Yeah, yeah, yeah.

But you'd be my guess. Well, the pills are not that expensive. That's my point. You know, oh, right. Okay, I see what you're saying. Yeah, that's my point. Yeah, the pills are about 500% less expensive. Exactly.

But I'm looking at Memorial Sloan Kettering. I just want to see if they've got anything interesting. not a slumpy place. Let me see if they've got anything interesting about nicotinamide, purported use and benefits to prevent skin cancer. Now, we did talk about that before. A large study found that taking nicotinamide can reduce the risk of getting certain types of skin cancers and also may reduce the occurrence of rough scaly patches.

It's also used as medicine for treating skin conditions such as acne and rosacea. but so far I don't see a whole lot of anything in here that says any interesting information regarding it versus infusion. But I am a fan of nicotinamide, and if you're at risk for certain skin cancers, I would certainly take it. It enhances repair of ultraviolet radiation, I'm sorry, radiation-induced DNA damage in human melanocytes, which, you know, presumably would reduce the risk of melanoma, which is a shit cancer that can kiss my ass. I'm really putting my neck out there saying cancer sucks and melanoma can kiss my ass.

All right, it's well tolerated, so there you go. All right. I'm in favor of it. Don't know that I would pay extra until we find out more about whether the IV is somehow superior to taking the pill. Okay. Sounds good. All right. What else you got?

We good? Okay. All right. You got all from there? Okay. Let's go back to the year of 2024. I hope that person's still alive. I know. I know. Here we go. Hey, Dr. Steve. This is Jeff in Ohio. I had a question. Someone in my gym told me that if you drink diet soda, the sweet taste on your tongue

causes your body to release insulin, and because you're releasing insulin, you're gaining more weight, and you are more likely to eat more sweet foods after that. I just was curious on your opinion. Did I say 2024? Woody just pointed out this is a phone call from the future. This is from 2014.

14. If that does actually cause the release of insulin or artificial sweeteners in general, if they cause the release of insulin. Yeah, this person was really ahead of the curve because that's something that really hasn't been fully elucidated until recently, that if you drink something that – because I was always like, oh, no, artificial sweeteners are totally fine. If you drink something that tastes sweet to the brain, it's like, okay, there's sweet stuff. where's my carbs? And when it doesn't get the carbs, then you start to crave them to kind of assuage that, the hunger, you know. And it probably is from a release of insulin through some other mechanism. So it's pretty interesting.

And or it may just be a brain thing where the brain is, it just has a mechanism by which it says, here comes some carbs. Wait a minute. Where are they? because I know if I drink something with artificial sweetener in it and I come home, I will just eat popcorn and rice cakes with penis butter on them and everything until I'm just completely stuffed what you're going to say to.

I think it's true. Yeah, I do too. So that seems to be a real thing. And that's from 10 years ago. That's pretty good. Very well done. All right. Here's another one from April 24th, 2014,

Area Code 774 Hey, Dr. Steve. Hey, man. Everybody tells me I've got a prostate problem, but I've had every test in the world, and I don't have a prostate problem. What I do have is a muscle that runs right underneath my navel that goes from one hip to the other hip, and it feels like you get tightened up like a big rubber band.

And it makes it hard to pee. And they want to throw me on these slow-max drugs or whatever, and that just ruins my sex life and this and that. I didn't need some other extended help. Thank you. Come me back, 7-7-1. Okay. Yeah, he wanted me to call him back.

Sorry, man. It was nine years ago. Yeah, so he has a muscle that is causing difficulty urination. What are you got? Well, as I was going to say, he thinks it's a muscle. Yeah. What do you think it is? God.

Diffica. It sounds like a prostate. You sounded like you had an answer. No, hell, no. I was just like a muscle that runs from your navel to your hips, not so sure. Yeah. But, you know, it sounds like they're treating prostateitis, which would be the norm. Yeah, they wanted to put him on Flomax.

If he wants to know. Yeah, I'm sorry. Well, back then, we didn't have some of the tools we have now. What I would do is I would shove an ultrasound probe up his ass and measure the size of his prostate and then the other thing you can do is a thing called monometry where you stick a balloon up your

cockhole into your urethra and then see if there, how much resistance there is to flow from the prostate across to the urethra and if there's a huge drop off in pressure

then it probably is a prostate problem. But you know a urolog don't, if you have a a problem like this and your primary care is just throwing pills at it, go to a urologist and let them actually, you know, do some

studies on you and see, he could have a urethral stricter. Right. There's all kinds of stuff. He could have a herniated disc in his lower back and that could give him... Give myself a bell. I already got one Scott, so we're even. Right. Damn it. Yes.

But you know, but you know, but to be clear of the prostate, you know, having a prostate problem. You're going to have a couple of things. Well, everybody equates inability to pee to having a prostate problem. But that's not always what it is. Or what about paying too often?

Could be, but not always prostate either. Yeah, so we'll talk about that next. Yeah, and when you go to your earald, just typically they'll give you a sheet and they'll say, fill out these, you know, one to five. How many times do you urinate at night time? Right. You know, and typically if it's more than twice, that's an issue. Do you feel like you're going to have an accident before you can. void your bladder.

In other words, can you get to the bathroom before you pee your pants? Right. That's an issue. When you feel like you've, when you've peed or you're still feeling you have to pee more. In other words, you can't avoid your bladder completely. Right. Or do you have binary flow where you pee and then you have to pee again?

Or you pee and it's forceful and then it decreases and then it comes back again. That's binary flow that is also a sign of prostate issues. or if you're sitting and pissing in the morning because you read the newspaper on the John or whatever and then you get up and then you get in the shower and now you have to pee again. That could be another one. That's also called binary flow.

Do you guys work in a way such as women my age have to pee but we also have to lean forward to get the rest of the pee out? I just wondered if you guys have to change positions. We don't have a vaginal wall that's weak and so that the bottom of our bladder is dipping down into our vaginas.

Nice. But that pulls fluid that causes you to have to lean forward and that's really more what that is. There is treatment for that. But if you're processing... Is it surgery? No. No, it doesn't have to be.

This is the one time when we can use estrogen cream to tighten up and thicken the vaginal wall or you can use a device called a votiva, which is basically a dildo that has micro needles on it, that you shove in and out and turn radio frequency and electricity on, and you go in and out. And what it does

is it will tighten up the tissue as well. That is not a procedure that I can do. Well, what if it didn't work for you? Because the first time that I did one, where you take an electrified dildo, basically, and you, you know, go in and out and in and out, in and all around, the first time I was, you're I did that. They'd say that creepy old man assaulted me in that office. Okay, so creepy old man. What if I have already done that?

I'm still having that issue. Well, how many times did you do it? Because you're supposed to go back and back. The total amount of times that you're supposed to. Okay. You say that. I don't think that's true. I did.

You got relief initially, right? Yeah, I did. But, I mean, it's still there. I mean, it's better. But then you have to go back. But I've been noticing. I've been having, well, I'm not. Right, exactly.

I'm not fucking. paying that, but anyways. Fair enough. Well. What about the cream? Let's piss yourself. Let's talk about the cream. Well, no, the cream.

I can lean forward, Steve. I can do that and not piss myself. Okay. Yeah, you can do the cream. You just talk to your OBGYN about that. Okay. Yeah, absolutely. Go ahead.

Well, and I was just going to say, but we have a similar thing. If the prostate swells, the prostate swells up into the base of the bladder, the bladder bloops over the prostate. Correct. And now we've got the same kind of resellus. very similar issue with all that the urine is in that little ring above the prostate inside the bladder. Right.

It's kind of sloshing around in a ring instead of emptying. How do you get it out? Well, it's a whole other thing. You can lean forward, lean back, and leave... Wiggle around a little bit. Yeah, but the difference is that it doesn't pull up in one area so we can't just lean forward because it's kind of in the circumference. It's around

the prostate. What would be good is if you could get on one of those rides where you stand there and it spins around and then it raises. Like a tilt-a-whirl kind of. That would do it. That would totally fix it. That would totally fix it. But, you know, for this guy, it could be a disc, it could be neurologic, it could be prostate,

but there are a lot of tests they can do now that are not as painful. A urethral stricter where he just has a narrowing of the tube going from the bladder, to the outside world. And those are easy to fix, but he needs a urologist. And I'm hoping in the last nine years that he did that. Let's hope so. God. Oh, this is terrible.

Okay. Oh, wait. Uh-oh. Oops. Oops. Hang on. My wife has had HPV since we've been married. And I just now, it's been seven years.

I just now started getting works on my dick. Should I be concerned? Okay. Now it's been 16 years, so yeah, you've got to get that treated. Unfortunately, certain varieties of HPV can increase your risk of penile cancer, rectal cancer, head and neck cancer and stuff, which is why, listen, they're not anything you can do about it now. Just get one of the lesions tested, see if you're at risk.

If you are, listen, knowing you're at risk means you're less likely to die from whatever that thing is. If you know you're at risk for colon cancer, you're going to get your colonoscopies more frequently, and you're going to be less likely to die from it. So do that, and then vaccinate your kids with the Gardasil or whatever, you know, when you listen to this another nine years in the future, whatever HPV vaccine there is, those are anti-cancer vaccines. Those are not STD vaccines. Those are vaccines to prevent head neck cancer, anal rectal cancer, cervical cancer, and penile cancer. And all of them suck.

And to understand that HPV is everywhere. Yes. Yes. Right, right. It's like 48% of people. If you bone a random person, you've got a significant chance of being exposed to HPV. Why would you do a crazy thing like that? If they've ever had an abnormal pap smear for one.

But anyway, all right. Let's see here. God, I don't know what this one is. Okay, this is from April 24th, 2014. I think we'd just keep doing this until we run out of phone calls. Dr. Steve, this is David in Augusta, Georgia. Hey, David. A 52-year-old lesbian trapped in a man's body.

Fair. Okay. I noticed this growth between my left class. and trapezeous about midway that I thought was an old people's wharf, one of those big round ones, and throws a hair, skits in the way. Sure, a skin tag or something. Yeah. Then I noticed it became translucent, and I popped it, and out came this irregular, white-shaped object about the size of a pea, bright white, very little blood,

mostly what I think is serum, came out with it. Yeah. And I think it was a fibroid. It reminded me of what came out of some ovaries when I was working as a surgical technician, except a whole lot smaller. Yeah. Was this indeed a fibroid, and if it was, what was it doing up there around my clavicle? That's a good question. Any of the cysts that form in the body will turn white, will have a white sort of,

outer layer, and I'm talking about epidermoid cysts, you know, they'll all be white. So the only way that you would know if this had been a fibroid would have been to take it to a pathologist, have them slice it up and look at it under the microscope, and that would have characteristic cellular thing. But I have taken out, now, lipomas are generally yellow and well-scranscribe, but I've taken out cysts from people that grew because they had a trauma. the skin. And what happens is, if you think about it, your skin sluffs, it's constantly sloughing off. There's layers, and the deepest layers produce the layers on top, and then it keeps

producing until they become flattened, keratotic-looking. They're hardly even cells, and then they sluff off. And this process is just continually happening and regenerating. Well, what happens if you, to have a puncture wound that drives some of the cells that are cruelly? creating carotinized dead cells that slough off. Now they can't sluff off anymore, but it'll keep producing them. Well, it's going to make a cyst. It's going to make a cyst under the skin. And every once in a while, you can, you know, feel one of those.

And it feels like a nodule. And if you cut it open, it'll be white. And the junk inside it will be chalky white sort of looking stuff. You know, it's like compressed cottage cheese. Yeah, it's oil. It stinks and it's greasy. And what that is is that that's just, those are skin cells that never slept off. What if it's hard?

Well, yeah, if it's hard, then it may just be small enough that the thickness of the cyst wall is large compared to whatever's inside it. And that'll make a hard one. It feels like a little BB or something. Yeah, yeah, yeah. And that granulated tissue is kind of like that. It all has to do with how big the thing is so that what is the ratio of the thickness of the cyst wall compared to the cyst itself. So I guess I can tell this story. There was a person once that had a big giant one on their back, and it got infected.

And when they get infected, they get even bigger. Okay. Now all of a sudden, because when these, that was me again, sorry, when the cells are dividing, they'll get to a certain point where the external pressure will equal the internal pressure. The pressure to grow will be halted by the pressure of the skin overlying. They can't go any further. Well, when it gets infected, all of a sudden, it's like going when the sun starts burning, card. instead of hydrogen, it's so much hotter and it will blow up the sun will become a red giant, right? Like beetle juice. So these things will do the same. When they get infected, that pressure will increase and now they can become much, much bigger. But now it'll be all kind of fluctuate.

And if it's on somebody's back and it's really tight, and then you go and take a number 11 scalpel, which is the triangular sharp one, and you stick a hole in that, to relieve the pressure, and it's under enough pressure that it starts shooting out, pos-infected fluid, basically. And it's all broken down. It was sort of cheesy stuff. Now it's just fluid because of all the bacteria have just been eating it, and it stinks. And when that happens, it happens so quickly.

You're surprised, and what do you do when you're surprised? You go, like that, and you open your mouth in surprise, and all this stuff goes shooting into your mouth. and covers up your glasses. And now you've got a mouthful of somebody else's pus. Your glasses are completely covered. You can't see anything. And now you can't stop. You've got to keep going.

You can't just stop. You can't turn around and puke. But nowadays you'd have a mask on. Nowadays I would have a mask and a shield. I would. I did every other time after that because I was pretty green when this happened. And that only has to happen to you once. And once.

Yeah, it's plenty. But anyway, now when that happens, then you end up with a big cavity and you got to jam it full of this stuff called Liota form. But anyway, it's, yeah. So that one was fluctuate because the ratio of the size of the cyst to the thickness of the cyst wall was very great. And the closer to one-to-one it gets the harder and less elastic, Those things will be. Okinault.

Two. All right. So I think that's probably what that was. If you express something from your body and you don't know what it is, you can always just stick it in saline or oil even. Like put it in a jar and you can pour oil over it. Yeah, just to preserve it and take it and have a pathologist look at it under the microscope. All right. Okay, doke.

Same guy. Nope. Okay. Here we go. Here's one from April 26th, 2014. I'm sorry, y'all. I don't know how this happened. Hey, Dr. Steve. Hey. Last week, O&A show they were talking about Ken's body and brain smell this during the grain. Okay, I can't understand what he's saying. So I'm going to move on. Sorry, man. You waited nine years for that. You want to just rewind it? No, I couldn't understand him. So I think it was his audio. Good, Dr. Steve.

My name is back from Maryland. I'm a disabled back. I've been dealing with back tissues for a while. Thanks for your service, too, man. And recently, I've been having a pain and shooting down my leg against the static pain. It's caused my foot, it was part of my calf to go really, really tight, and then my foot's going up. Okay. Now, we've been going to the VA Medical Center.

They've been giving me a prescribing dab. Yeah. I don't know. I looked it up and it says it was for some nerve stuff. Yeah. We use it every day now. Back then, it was not so far. Hey, take that for a while and it should get better.

But my wife's been trying to convince me to go to, what is it, Philadelphia spinal lasers. Oh, that's the place I almost went to. I know exactly what he's talking about. So here's the thing. And Dr. Scott can talk about this some. And we've got, I don't know, we've got about two minutes left. If you have a slip disc or whatever, a herniated disc in your back, or if you've got spondylolisthesis where the bones are not lining up properly, whatever it is, and it causes pain that runs down your leg, that we will often call that sciatica, but it's really lumbar ridiculopathy is the correct term for that. And, but if it is accompanied by neurologic deficit, in other words, a floppy foot, or you can't

You can't feel. Right. Okay. Go ahead. You take you. Well, but, no, but that's the big red flags for sciatica. If, number one, if you lose, you lose sensory function. Right.

So you can't feel your leg. You can't feel your foot. You get numbness that doesn't resolve when you change positions. Right. Or you can't control your bladder. You lose control your or your bowels. Those are surgical. emergencies. That is correct. That is an occasion to go get that shit looked at, ASAP. Right. And sometimes it will be surgery. Now, the surgery that they were doing at that place, they're still doing it, is sort of a novel surgery where rather than putting in a cage, they have stabilizers that go in and they open up the parts of the, I'm trying to do this in lay terms.

parts of the vertebral body that are causing the pressure, they'll cut those out, but it makes it unstable. So they put this thing in that is not a cage, it's not fixed, and what it actually does is allow you to still bend your back. And it's a really neat surgery. I consider doing it when I was in my extremist, which thank the good Lord above, that I have a really good physical medicine and rehab provider that knew what the hell. they were doing and got in there with the right kind of needle, the right kind of medicine. I can basically do anything right now. I could go to Disney and walk 10 miles, I'm convinced, right now, and not even think about it. Yeah.

And then see people like Dr. Scott. Dr. Scott works with pain management, people to do the same kind of things. Every day. And you can do this without surgery, without opioids, but there are some cases where you just got to go do the surgery. Yes. Yes. Sensory loss, motor loss. In other words, if now you can't move your foot, or like you said, you know, foot drop.

Yeah, foot drop. Any time, any major change like that. But if it's not that, and sciatica can be, like you said, actually the lumbar ridiculopathy, which is a we would call a discogenic sciatica. Right. And the other kind of sciatica is a periformis syndrome. So you have a muscle actually spasying. I'm going to have to give him a bell.

Give thyself a bell. Suck it. Right. So pureformis syndrome. Yeah, so that's a muscle that's actually spasoming around the. It gives you almost the exact same signs and symptoms, the same problems with the pain and misery, but it's actually from a muscle and not your spine. And you can treat that yourself with stretches and home.

And, you know, acupuncture needles work real well. Ice can help. Of course. You know, heat can help. Sure. I mean, if you think you might have that, Google Puroformis syndrome. And there are videos out there that will show you the exercises. He just got that bell because he was paying attention and not to the heat.

that we're currently enduring. Well, that's right. It's amazing how not hot it is outside, and it got really hot up here. That's crazy, yep. I look forward to moving the studio to your place, Scott. Okay, well, let's get out of here. Thanks always go to Dr. Scott and Tacey. Thanks, everyone who's made this show happen over the years.

Listen to our Sirius XM show on the Faction Talk channel, Sirius XM Channel 103, Saturdays at 7 p.m. Eastern, Sunday at 6 p.m. Eastern on demand. Other times at Jim McClure's pleasure. Many thanks to our listeners whose voicemail and topic ideas make this job very easy. Go to our website at Dr. Steve.com for schedules, podcasts, and other crap. Until next time, check your stupid nuts for lumps. Don't listen to my niece Holly. Quit smoking. Get off your asses and get some exercise. We'll see you in one week for the next edition of Weird Medicine. Thank you.

Thank you.