Weird Medicine: The Podcast - 582 - Secret Life of Testes

Episode Date: March 13, 2024

Dr Steve, Dr Scott and Tacie discuss: Type I diabetes breakthrough washing the pen15 ever so gently healthy male gonads and junkal region paxlovid and lactose when in the hell did we EVER endorse copper bracelets? different types of dementia spicy food science Please visit: simplyherbals.net/cbd-sinus-rinse (the best he's ever made. Seriously.) RIGHT NOW GET A NEW DISCOUNT ON THE ROADIE 3 ROBOTIC TUNER! roadie.doctorsteve.com (the greatest gift for a guitarist or bassist! The robotic tuner!) see it here: stuff.doctorsteve.com/#roadie Also don't forget: Cameo.com/weirdmedicine (Book your old pal right now because he's cheap! "FLUID!") shoutout1.com/weirdmedicine (either one works!) Keep Dr Steve in Ham Radio! Send a TIP here! Most importantly! CHECK US OUT ON PATREON!  ALL NEW CONTENT! Robert Kelly, Mark Normand, Jim Norton, Gregg Hughes, Anthony Cumia, Joe DeRosa, Pete Davidson, Geno Bisconte, Cassie Black ("Safe Slut"). Stuff you will never hear on the main show ;-) Learn more about your ad choices. Visit podcastchoices.com/adchoices

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The Navy offers new graduates hands-on training and experience in careers like computer science, aviation, and medicine. Plus, education and sign-on bonuses. Parents, help your grads start their career today at navy.com. Man, you are one pathetic loser. Can you like, shut up? If you just read the bio for Dr. Steve, host of Weird Medicine on Sirius XM103, and made popular by two really comedy shows, Opie and Anthony and Ron and Fez,

you would have thought that this guy was a bit of, you know, a clown. Why can't you give me the respect that I'm entitled to? I've got the period crushing my esophagus. I've got to bolivide stripping from my nose. I've got the leprosy of the heartbound, exacerbating my impetable woes. I want to take my brain out and blasted with the wave,

an ultrasonic, agographic, and a pulsating shave. go on to magic pills, all my ailments, the health equivalent to citizen cane. And if I don't get it now in the tablet, I think I'm doomed, then I'll have to go insane. I want a requiem for my disease. So I'm paging Dr. Steve. From the world-famous Cardiff Electric Network Studios in beautiful downtown Tuky City. It's weird medicine the first and still only uncensored medical show in the history broadcast radio. Now a podcast.

I'm Dr. Steve with my little pal, Dr. Scott. Traditional Chinese medicine provider gives me street crad with the wackle alternative medicine assholes. Hello, Dr. Scott. And my partner in all things, Tacey, hello, Tacey. Hello. This is a show for people who would never listen to a medical show on the radio or the Internet. If you have a question, you're embarrassed to take to your regular medical provider. If you can't find an answer anywhere else, give us a call 347-76-4-33.

That's 347. Follow us on Twitter at Weird Madison. We're at D.R. Scott, W.M. It's hard for me to say, follow us on X. It's still Twitter. It's still Twitter to me, damn it. Visit our website at Dr.steve.com for podcast, medical news and stuff you can buy. Most importantly, we are not your medical providers.

Take everything you hear with a grain of salt. Don't act on anything you hear on this show without talking it over with your health care provider. Don't forget to check out stuff. That's stuff.doctrsteve.com. That makes a huge difference just using it. that. Thank you for using it. You can just click through to Amazon or you can scroll down and see stuff that we talk about, including the Rodee, R-O-A-D-I-E, robotic tuner and the Rody Coach that'll teach you out to play a stringed instrument. You can go to stuff.com or you can go to

rody.com.com. And then Dr. Scott's website at simplyerbils.net, which we'll be talking about in a minute. And patreon.com slash weird medicine. The live streams are starting to roll out. I'm trying to do them at least every other Friday night and sometimes every Friday night. And I'm working on the technical details. I'm thinking, though, having two studios in this house, well, we have four now. I have one for doing the bits for normal world with Dave Landau on Blaze TV.

I'll be doing a regular segment on there called Ask Dr. Steve, and I have to have a teleprompter, and I've got to be in front of a green screen, and then they fiddle with it and do stuff. And then I have the live stream studio, and then we have the music studio. Oh, and then the ham radio studio. And then the voice studio here. It's kind of too many studios. So I'm thinking I'm going to switch the live streams into here. Technically, it'll be better. And I think it's just overkill to have a separate studio just for.

every other Friday night doing a live stream. But I am going to change these cameras. These cameras right now are too far away, and they just, you know, I have a degree in television directing, and it really just misses up my sensibility. They're conveniently placed for this room, because they're out of our way, but they kind of suck. So I'm going to work on that.

And anyway, so patreon.com slash weird medicine. If you want to leave us a tip, you could go to tips. Dottersteve.com and spell out doctor. And supposedly you can leave a message on there and it comes up on our live stream. I don't know. No one's done it yet. So we don't push that kind of stuff. But if you wanted to do it, we'll see if I can make it interesting.

There's this guy, Patrick Melton, and he's very controversial. But he has the most, what's the word I'm looking for? It is comprehensive and advanced tip system. I've ever seen you go to his tip thing and you could pick one of the characters from this universe. Like, let's say you want to have Aaron from Steeltoe Radio say your word. So they have an AI voice generator. and they do all these different people. Chad Zumach's got one, Kevin Brannon, all these different people.

And then you put in words and then you pay money. And then during the show, it will pop up and they've got a picture of their face and it will say whatever you told it to say in their voice. It's crazy. Now, I'm not going to go nuts like that because that's, you can only, you can't do that if you're doing a podcast and a serious XM show and all this stuff because, you know, we're basically an audio thing. Right.

But if we ever did a video, I would love to talk to him to see how the hell he did that. Sounds pretty complicated. It's very complicated, but it's cool when you see it. Sure, sure. But anyway, that's tips. dot, dr.steve.com. And then if you want me to say fluid to your mama,

it's very inexpensive five bucks. I'll say whatever you want me to say at cameo.com slash weird medicine. Check out Dr. Scott's website at Simply Erbalstubes. That's simply herbals.net. Somebody sent me a picture of CBD nasal spray, and it was not yours. So somebody out there is also making it. Terrible.

But anyway, I haven't tried theirs, but of all the CBD nasal sprays that I've tried, Dr. Scots is the best. Far superior, far superior. Check them out. Simplyerbils.net. Don't forget to check out Dr.steve.com. That's Dr. Steve.com. and, you know, whatever. So I do have a story that I want to do,

if I can figure out a way to bring it back up because I had it. There we are. This is huge. This is a big one. Diabetes breakthrough, FDA-approved drugs, regenerate insulin production

in 48 hours in type 1 diabetics. Okay, we're in, We're another step closer to reducing the need for round-the-clock insulin injections to manage diabetes after a new study showed how insulin-producing cells could be regenerated in the pancreas. You know, we've been talking about pancreas transplant or islet cell transplants, or as Dr. Scott calls them islet cells, because that's how they pronounce it in China. That's what he says. Anyway, so, you know, we've been talking about that. We've been talking about artificial pancreas. Well, hell, we didn't think about a drug that might be able to just regenerate the cells that make insulin.

Wow. So the pancreas has two different effects that has exocrine effects. In other words, exocrine glands are those that secrete something into something else, but not the bloodstream. So the pancreas produces pancreatic enzymes that are digestive enzymes. They help to break down fat. And if you don't have that, you end up with steateria, which is basically oil globules in your bowel that go through undigested. And then, you know, when you have this sort of diarrhea with it, you'll see oil floating on the surface. So if you have that, you may have a problem with what we would call pancreatic insufficiency.

Gotcha. But it also has endocrine functions as well, and one of the most important things that it secretes into the bloodstream. So an endocrine gland secretes things into the bloodstream. Testicles are endocrine glands when they secrete testosterone into the bloodstream. The thyroid is endocrine. So anyway, the pancreas secretes insulin. in response to elevated blood sugars. So you have to sense that the blood sugar is elevated,

then you have to secrete insulin in response to it. Then you've got to stop secreting it when the blood sugar gets, starts to come down. Not doing that from eating tons of carbs where the insulin overshoots and then they end up with low insulin, or I'm sorry, low blood sugar levels, and then the body starts turning down the sensitivity to that signal is what causes type 2 diabetes. Okay. So that just sort of give you the background of the pancreas.

Anyway, in type 1 diabetics, there is some immune thing, whether it's, we don't still know what the trigger is. If it's a virus or a genetic or bacteria or something. Sure, but something. There's some antigen that we become exposed, that we get exposed to. the body develops an immune response to it. And then when that thing is gone, whatever it is, virus, bacteria, parasite, whatever, then those antibodies turn against the cells in the pancreas

because there's something similar there. And they kill them. And then when they kill them, you don't have the ability to produce insulin anymore. Your blood sugar goes up. You show up in the hospital the first time with a thing called diabetic keto acidosis. That's almost 100% of the time how kids will present with, and that is diabetic, meaning they're pissing like a racehorse and they've got high glucose.

Keto, they are making ketone bodies because they can no longer take sugar from the bloodstream and put it into cells and use it for energy, so they have to start burning fat. And that produces ketone bodies. And then acidosis because, well, they become acidotic. And, you know, their hydrogen and potassium start to shift. And they're trying to buffer the hydrogen ions, which are the acid ions. And then they fail and they end up coming in with a very low pH. And this is a medical emergency.

Back in the day, if you had a kid that had diabetes, you know, in the 1500s, they didn't survive. Oh, gosh, yeah. And, but now the treatment is to get them on an insulin drip, get the blood sugar down. And as soon as you start to, it starts to come down, you actually have to start glucose because they need energy, too. So, and if you, if you stop the, the insulin drip when their blood sugar becomes normal, then you're too late. No, no, it's too early. You fucked up. Yeah, you fucked up.

And I see this a bunch in, or in terms. where they will start the insulin drip, and then they say, oh, now their blood sugar's down to 120. Okay, gotcha, got you, got you. And then they stop it, and it just comes right back again. Okay, gotcha. And then you have all kinds of things with the pH shifting is you've got to look at phosphorus levels and potassium levels, because if their potassium is normal when they come in, it ain't normal.

Because they've been pissing out potassium to try to replace, to try to buffer out the hydrogen ions. because they're trading places in the cells. And so you'll get a bunch of potassium comes out of the cells as the body shoves these acid, you know, the naked protons into the cells. Okay. And they exchange. So the potassium comes out and it's floating around the bloodstream. They piss it out.

So if they have, it should be high. Right. Right. Right. It should be. If it's normal, it's actually low. And low potassium can lead to cardiac, severe cardiac problems. So when all of a sudden you get that blood sugar down and the acidosis goes away, right?

Because you've got insulin going in there. All of a sudden, the potassium will precipitously drop because it was actually low anyway. And particularly as those potassium ions start to work their way back into the cells and it's not in the bloodstream anymore. So anyway, there's a whole lot of shit that goes on during diabetic ketoacidosis and it's a real process to stay on top of it. Well, wouldn't it be nice if we didn't have to ever deal with that anymore? Yeah, sure. So here we go. This is, the breakthrough was made by getting pancreatic ductal progenitor cells.

These are the cells that give rise to the tissues lining the pancreas ducts to develop the function of beta cells that are usually ineffective or missing in people with type 1 diabetes. So what they did was they took these ductal progenitor cells that are supposed to make. duct cells and said, you know, instead of making ducts, make some insulin, will you? Mm-hmm. Mm-hmm. So pretty cool. I know. This is a real out-of-the-box answer because we were looking at stem cells and all the

stuff is just, why not, well, these are kind of stem cells. That's what I was going to say, almost like a stem cell. It's almost like a stem cell. Yeah. But they're already, the difference between these and stem cells is stem cells have not really differentiated yet. These things have already differentiated. They're differentiated that they're supposed, they are stem cells to make ducts, not

to do anything else. But anyway, so they investigated a new use for drugs already approved by the FDA that target this echo ZH2 enzyme in human tissue. Ordinarily, this enzyme controls cell development, providing important biological check on growth. And there are two small molecule inhibitors called GSK-126. Oh, that sounds like a, that's probably Glaxo, right? Glaxos, a G-SK-126. Could you look that up and see if it's a glaxode drug? And Tazimetostat already approved for use in cancer treatments were used to take off some of the breaks imposed by the EZH2, allowing the progenitor duct cells to develop

function similar to those of beta cells. So basically what they kind of did was say, we're going to allow you to become a sort of a cancer that we can control. Wow. Right? Because this molecule usually prevents cancer cells from forming. And they're like, in this case, let's just let this up. Now, I wonder if these people are going to, you know, if this drug is going to predispose people to malignancy, we'll see. Oh.

Targeting EZH2, because there's always some downs. Sure, sure, sure, sure. Targeting EZH2 is fundamental to beta cell regenerative potential. Reprogram pancreatic ductal cells exhibit insulin production and secretion in response to physiologic glucose challenge. Holy shit. So, in other words, not only do they produce insulin, but they do it in response to being exposed to higher levels of glucose. Hmm. Previous research had suggested cells that give rise to duct lining, which also help manage stomach acidity, okay, could be converted into something like beta cells in the right environment.

I wonder how they figured that one out. That's fascinating. I'd love to have one of these researchers on to explain that one. Now we have a good idea how to do it. Crucially, the new cells can sense glucose levels and adjust insulin production accordingly, just like beta cells. In type 1 diabetes, which the study focuses on, the original beta cells are mistakenly destroyed. Okay, by the body's immune system. All right, I'll give myself a bill for that.

I'm just kidding. Which then means blood glucose and insulin must be managed with regular injections. The test carried out by the team showed the same reaction in tissue samples taken from two individuals at type 1 diabetes, age 7 and 61. One, age 56 without diabetes, suggesting it could work across the generation. That's pretty cool. Yes, Steve, I don't know who makes this. Okay. Does it say anything about the drug that's interesting at all, tastes?

Well, GSK-126 is recognized as an inhibitor or enhancer of zest homelog dash-2 activity. Okay. Yeah. Well, there you go. And it's considered a potential anti-tumor drug. Right. Okay. Well, that's interesting.

Hmm. Okay, well, I guess when you inhibit these things, they activate, and when you inhibit them in cancer cells, I'm going to have to learn more about that. It's like those adaptogenic herbs or adeptogenic drugs that kind of do what you need them to do in that space. Well, maybe so. So I'm going to have to become an expert on this over the next little bit because this is going to be something we're going to get asked about. But this is a big deal.

The research was published in signal transduction and targeted therapy. Now, okay, so these are FDA-approved drugs. They are not FDA-approved for type 1 diabetes. So that's a little bit of a misleading headline as per usual. But they are FDA-approved, which means they have been through phase one, phase two, and phase three, and they are in phase four for cancer. So we don't have to worry too much about the safety aspect. We already know those numbers. They'll have to do a perfunctory phase three.

I don't think they'll have to do phase one or phase two for these drugs for this particular indication. It's going to take a drug that's off the shelf and do and look at it for a different indication. And it's when someone like, I mean, maybe with your experience, could write it off label. Oh, yeah. No. Anybody could write it off label. The problem is getting insurance to pay for these. I suspect these things are fabulously expensive.

I would think so, yeah. Fabulously. I would think so. But those studies will be done. If one of you all wants to go to clinical trials.gov and look at one of these drugs and see if there's anything there. But anyway, all right? So, yeah, clinical, if you have type 1 diabetes and you're interested in getting into one of these trials, they are going to be recruiting if they're not already very soon.

And you go to clinical trials.gov, put in type 1 diabetes for the condition. And then the keyword would be G.S.K.126. Or do you want me to spell this for you, Dr. Scott, because other people may want to be following along with this? Sure. Are you there? Are you in there? Almost. Oh, well. Well, here's the thing.

It changed The old clinical trials website is, of course, a different website now. It is. It's a different URL. Really? It's not clinical trials.gov anymore? It's got...

Yes, it is. I'm there right now. Okay. Type 1 diabetes. It's okay. It's okay. It's okay. I swear to God.

It's okay. I put in Type 1 diabetes, Tazametostat. And let me put that in, as intervention. And then we'll just see if we come up with anything interesting. Okay, here we go.

It's okay, buddy. I'm forbidden. He is forbidden. Really? It says forbidden, yes. Interesting. Okay, so far I see nothing for Tamo Zito stat or whatever the hell it is.

So we will stay on this. and go from there. Okay. But it's coming. Very interesting. I publicized this as huge breakthrough, and now I'm not so sure it's such a huge breakthrough. But, I mean, it is...

It's something, though. It is a huge breakthrough in research, and these RFTA-approved drugs, but they're not quite ready for prime time as far as actually giving them to people. I couldn't find a single trial on clinical trials.gov, but I'll keep on it. If we come up with something, I know there's a lot of type 1 diabetics in our audience and people who have type 1 diabetics in their family. If you want to look at this study, I'll be happy to send it to you. Just email me at DR Steve 202 at gmail.com, and I'll send the actual study to you to show the patient in your family

or to show their doctor just so that they know that this stuff's coming, okay? Yeah, don't you think it's still incredible, though, with how pervasive type 1 diabetes is, there's never been a real solid answer on what causes it or how to fix it. Yeah, it's crazy. It's been around for so long. Well, I mean, it's true. There's a bunch of things like that. ALS is another one.

True. We finally kind of know the underlying molecular basis for ALS, so we should be able to develop a treatment in the next few years for that. Still not a real good idea for why it happens. So dementia. Dementia, sure. Another one. Pretty common stuff, yep.

All righty. Oh, my goodness. Okay. I'm very surprised I couldn't find a single study, but I may not be searching for it correctly because I'm trying to do it on the fly. Well, I'm on here now. I can help you now. Okay. You ain't forbidden that more?

I found the back door. Oh, God. That's Scott's favorite thing. I'm a back door man. All right. Tacey, do you have topic time with Tacey? Why, of course I do. What comes to mind when you picture the perfect roommate?

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Well, hello. Hello. Today's segment is for the stupid people in the audience. Oh, no. Okay, Scott, pay attention. I'm listening up. Mr. Clinical trials. First topic is how to wash your penis.

Oh, okay. Okay, we all need that. Wash your pubic mound and the skin around the base. of the penis as well as the skin between your thighs and your pubic mouth. Okay. Is there a reason that you brought this up, or did you just happen across it? I'm just wondering if I have a problem. It's the second half of the everything you need to know about penis health.

Oh, okay. That's been good. I am going to confess that I am stupid. I bought these sheath underwear and they say, oh, you got this pocket for your junk and all this. I can't figure out how to work the fucking things. They're underwear, and I cannot feel. figure them out. Yeah, don't have like the cut or something.

I would show you except I don't want to just pull my junk out in front of you. But there is a pouch in there, but if I have to piss, if I have to piss really bad, like if I'm at work and I'll hold it for a long time, and then I get in there and I can't get my junk out because they're boxer briefs and they're real tight, like skin tight. So I can't just pull the underwear out of the way. And I reach in there and it's just a blind pouch. And then you have to reach in there and then get in this other thing and then pull your junk out. It's the craziest damn thing I've ever seen. That's terrible for prostate issues. He's going to show it to you.

Yes, I can't why. Well, I do. I got them out today and looked at them. I said, I am not stupid. But anytime I do that, I can usually figure something out. Like if it's something that's been driving me crazy, it's like I'm not dumb. I can figure it out. I can't figure them out.

It's like a trapdoor. I love the way they feel, though. They're my favorite underwear I've ever had. And they're not sponsors of the show. I was a Tommy John guy. But I bought these sheath boxer briefs by accident because I thought I was buying just regular briefs because I don't like the saltwater taffy, scrode them against the thigh feeling.

And these don't do that. They're perfect. But I can't figure them out. It's too complicated. That's awful. Anyway, go ahead and taste. So obviously, I need some help. Tip number two, wash the shaft of your penis.

If you have a foreskin, gently pull it back and wash it. This helps to prevent smigma. Let's your scrotum and the skin around it. Oh, my gosh. This is why it takes you guys so long to shower. Wash your perineum. That's the skin between your scrotum and anus. Well, we call that the taint, don't you know?

Wash near your anus and between your butt cheeks. And wash it every time you bathe. Yes, do that last. And be sure to watch for unusual discharge, rashes, blisters, or. warts. You know. Okay. How to prevent STI's.

What's that? Sexually transmitted infections? Is that what we're calling it now? Yes. Yes, that's the new... Get tested after every new partner. That's what the cool kids say. Use a condom every time you have sex.

Don't be one of those guys. That's stupid. What? To use a condom? To use the condom? To use a... Oh, to not use it. Oh, to not use it.

Yeah. Correct. I don't like it. I can't. Does it matter if you're circumcised? There are pros and cons to what? Being circumcised. If you have a foreskin, pull it back gently and clean it to avoid a smegma buildup.

Circumcised penises are more likely to get chafed or irritated, so use loose-fitting cotton underwear always. Circumcision doesn't affect fertility, but uncircumcined penises are more susceptible to STIs as well as conditions like balinicions. Not as uncircumcised ones are? Yeah, you would think so. Uncircumcised piece. They're going to catch one of the bugs up in there. Yeah. Okay, I thought that circumcision, oh, uncircumcised, you said.

Okay, yeah, yeah, I'm sorry. And it doesn't matter if you're a grower or a shower. I had the image of a circumcised slung in my head while I was saying uncircumcised. Yeah, go ahead. It doesn't matter if you're a grower or a shower, just embrace it. Yeah, so the thing is, is that if it was a huge effect, we would be. know the answer to this. We wouldn't be arguing about circumcision.

Okay. So it's a very small effect. If you are uncircumcised, very small number of people will be negatively impacted by that. And a very large number of people will have maybe better sensitivity and better sexual Congress because they had it. People who have had circumcisions, a very small number of those will not get a disease. they may have gotten, but then the downside is the converse of the circumcision, and a circumcised person will never have to have a circumcision as an adult, which Sam Roberts

will tell you sucks. So it is a matter of choice. The problem is the kid cannot consent to it. So you're doing really what amounts to a cosmetic procedure, unless you're, you're, you You know, it's a religious procedure, but you're doing a cosmetic procedure on a kid that cannot give consent. And that's my issue with it as an issue of autonomy, because even kids that are 17 can't consent legally in this country to a medical procedure. They can give assent. In other words, they can agree to it, but they can't consent to it.

Only their parents can consent. Right. So, you know, that's an, that's my issue is that's an issue of autonomy, but, you know, fewer and fewer people are doing circumcisions, but there's still a lot of circumcisions being done. And when the OBGYN, does your circumcision, which was the case when I was training, it's the only time they touch a male patient is when they're doing, cutting part of their penis off, you know? That's kind of odd. But I'm not opposed to it, but I am saying I understand the argument. So are there fewer circumcisions going on these days? That's my understanding.

Okay. Well, Tacey's talking, I'll get those statistics. Is it normal for your penis to have a bend or a curve? A little bit, yes. Slightly. But if you have a significant bend and pain in your penis when it's erect, you could have Peroni's disease. Right. It's often caused by traumatic injury.

we've talked about Peronis a bunch but I bet you have you got the angle of the diagonal don't you know did it say in there whether it's more common to go to the left or to the right no it doesn't does not and I've had people call in

talking about oh my penis when it's a wreck curves to the right of the left that's actually a good thing whoever you are having intercourse with instead of just having a straight cylinder being shoved into whatever orifice it is, it's going to be a curved cylinder, right? So the curved cylinder, let's say it's curved, you know, the bow of the curve is bowed to the left.

So the right is, I mean, the tip is to the right, the base is to the right, the middle of it is to the left. Gotcha. When you stick that in that orifice, let's just assume it's a penis going in a vagina, but it could be anything. house, the tip will hit the right side more than the left, right? Then the middle will hit the left side more than the right. And then the base will then do likewise for the right side of that orifice. So you're getting more contact that way. It actually increases the apparent girth of the penis. It gives the illusion of girth. Yeah, that's right. Well, just Just like if you take two telescopes and separate them, you can increase the aperture without having a telescope that's, you know, a continent size big, you know.

So it increases the resolution. So it's the same sort of thing kind of. I mean, not even close, but it's, you get an idea. We'll get your point. But you get the illusion. Yes, the illusion. You have more growth. So if you have a bit of curve, that's actually maybe a good thing.

Agreed. Is use it or lose it true? No. While it's true that frequent sex has many health benefits and can boost your sex drive, there's no evidence that chastity can permanently or seriously damage your penis. I disagree. I think it absolutely damages. I think it's not according to health line, my friend.

Chick your sources. Damages your psyche. Is there such a thing as too much or too little ejaculate? If you're noticing that you're noticing that you. you are ejaculating a lower volume of semen than usual. It's called perceived ejaculate volume reduction. Oh, wait, perceived ejaculate volume reduction. Pever, Pever, Pever, Pever.

Yeah, Pever. He's got a paver. He's got one of that. He's got a paver. He took his paper out in church and showed everybody. This could be caused by a number of things, depression, diabetes. He was took up on. All right, Myrtle, shut it.

In certain testicular conditions, it could also be a side effect of medication. How can you maintain penis sensitivity as you age? Use it or lose it. That's easy. That's not, I told you. I've already told you. That's not how it works. Where's my bell?

You see? You see? You're stupid minds. Stupid. Stupid. The tissue on your penis might lose sensitivity as you age. This could be caused by friction. So use loose cotton,

underwear instead of tight, rough underwear that you can't get your junk out of. Now, mine is very silky. The sheath is very silky. How can you maintain your ability to get an erection? Reduce your risk of heart disease and diabetes. Yeah, don't smoke. That's number one. What can you do to promote fertility?

Certain foods. Did you know this? No. For example, spinach contains magnesium, which can boost your testosterone levels. What? Tomatoes and carrots can increase your sperm count and motility. Other than that, the healthy lifestyle choices help maintain fertility. Exercise.

Sure. But not too tight underwear because if you're wearing a jock strap all the time and you're pulling your nuts up against your body, they are supposed to be three degrees below body temperature to produce sperm. If they're constantly up in your mass, then they will. not be three degrees below body temperature. They won't be able to

regulate their temperature and you could become relatively, if not completely infertile. I have got a question about that. Yeah. So I'm just wondering, cold water therapy. Yeah. I just wonder of doing that too much would, and over

time be possibly damaging to Well, if you were just constantly immersed in. You guys just worry about anything that can damage. Or do anything to you know. Oh, it's shriekage. It's shriekits.

I got in my pool last weekend and it was... What that's wrong with you? Doing a cold water therapy. Oh, yeah. I think I actually... Oh, I think my... You got in your pool, though? Isn't it gross?

No, I keep it pretty clean. Even in the winter? You don't cover it? Nope. Yeah, okay. Well, he's a highfalut and everybody. Yeah. Why don't you just get a cold pool?

Like, they have at Shogi Spa up in Nashville. Because he has one. I'll say, my pool's cold as hell. Well, I know. I don't have to really worry about it. I don't only sit in it. I just go sit in the shallow one and just kind of breathe. Yeah.

How long? Usually about five minutes. I used to love to take really cold showers. Yeah, this is different. It feels good afterward. Yeah, this is different. I thought my nuts had crawled back up inside. They were going to have to descend again.

Hey, I've got some trans on circumcision. If I can go back to that for a second, it says across the 32-year period from 1971 through 2010, so this is not the newest, but national rate of newborn circumcision declined 10% overall from 64% to 58.3%. I would have thought it was lower than that still. During this time, the overall percentage of newborn and circumcised during their birth hospitalization was highest in 1981. Uh-oh, that was, well, no, let me see. I was 86 to 89, which was 65% lowest in 2007 at 55.4%. So it's still just above half. Go ahead. Tate, sorry. Okay. This is about P color. Okay. And this is also stupid. Clear urine could mean you're over hydrated. Yaller to

yellow. Yellow. Yaller. Oh, my lord. That is the most redneck. Oh, it came out. I try for it not to. Yaller. That is Joanne speaking right there. That is. Yellow to amber urine is. is considered normal. Orange or brown urine could mean you're dehydrated. Okay. But now listen, if you get bloody, cloudy, blue, or green urine, it could indicate that you have an infection.

Correct. So see a doctor. Okay. Hey, we'll go back to clear urine. Sometimes if you drink too much alcohol, you'll get clear urine. Again, because you're peeing out free water because the first taste of alcohol has a little bit of a diuretic effect.

Yeah, that's correct. So what if you start peeing more than usual? Okay. It could be a sign of a UTIR, diabetes, interstitial cystitis. Yeah, the people with interstitial cystitis will feel the need to pee more frequently, but the volume will not be increased. Right. People with diabetes will pee out an increased volume. That's why it's called diabetes, Dr. Scott.

I don't know if you knew that. Tacey was there when we talked about this on Opium Anthony. Diabetes is from the Greek word for siphon. So there's diabetes, melitus, which means that the urine that is shooting out of people like a siphon tastes like honey. Meletus is like, you know, is, you know, the Greek word for honey-like. Right. Sweet-like. And, yeah, like, meil is the Spanish term or a Spanish word for honey.

And then diabetes insipidus means that the stuff that came out of them was free water. It had no taste at all. It was insipid. Gotcha. And those people had brain tumors or other problems. And the diabetes melitus people had our classical, what we call diabetes. In Chinese, it's Shao Kuh syndrome, Shaukuh, which is a wasting and thirsting disorder. Oh, yeah.

That sounds like that sounds like. Now, do they distinguish between sugar diabetes? sugar diabetes He's got to sugar And diabetes Incipitous I don't think so Okay so they weren't drinking people's urine

They were civilized That's why Okay good for them He's got to sugar He's got the sugar Don't you know All right Diabitis

And he's got the pervert Listen shut up All right Okay Is it normal for your penis to smell I mean like sweat Yes But if it's

Pundit You can have a UTI, yeast infection, Bellinitis, gonorrhea, or chlamydia. Well, did you know, though, Tase, if your nose runs and your feet smell, you're built upside down, bad-burnt it. He's a fucking idiot. He's a fucking idiot.

That's terrible. That's awful. Now, when I was a kid, I was in Canada, in a Blind River, Ontario, and I was in this big lodge, and they had all these signs like that. And that's the one I remember. I was probably eight. Oh, how fun.

And I remember seeing that, and I didn't understand. It's like, you build upside down. It took me quite a while to figure I wasn't the brightest yet. Anyway. Oh, my goodness sakes. Okay. So if your penis is sore or inflamed, it could be a certain sign of these penis conditions. Ballinitis.

Phamosis. Okay, well, let's talk about what each one is. Balinitis is inflammation of the Roman Warhol. And you could get a traumatic balinitis or strangulation balinitis if you pull your foreskin back and it's tight and you forget to put it, to pull it, you know, to unretract it. It cuts off the blood supply and then sloughs off. That's bad. Famosis? Yes, that's narrowing of the foreskin.

And then penal cancer. Oh, well. Self-explanatory. You're a bummer. Let's go back to the cleaning. Although the penis doesn't have bones, the term penis fracture is often used to refer to a penis injury where the lining inside becomes torn. Yes. This is often caused by rough sex.

Yeah, so what particular position almost 100% of the time causes this taste? I would say the woman on top. Yes, there you go. When the woman is in control. Oh, that's a funny one. If you fracture your penis, it will turn black and blue flatten, and it may make a popping noise. And it hurts like a mother.

Mother, it'd have to. And it's very often when you've got a little bit of whiskey dick. Yep. You're not fully erect. Less than fully erect, you know, cat can't scratch it type erection. You know, ballpark weiner in the microwave. That's the, those erections are pretty. immune to fracture, but if you've got a little bit of whiskey-dicking, yeah, a little

softy, yeah. If it's slightly softer than normal, and it's not exactly in the right position, and the woman thrust downward, what it'll do is it'll bend the penis in half rather than allowing it to, and you don't even have one, and it still gives you the wound. Oh, goodness. Yeah, and then it'll fracture, and you have to. to go to the emergency room and the urologist may or may not attempt to repair it. But what's going to happen is that fracture site is going to become scarred.

And then you will, because scar tissue is inelastic, but the surrounding tunica around the penis is relatively elastic. When it becomes erect, it's going to, it's going to bend toward the side that is less elastic. So you'll get Peroni's disease. It could be severe, painful, preventing intercourse. It could be mild and you can live with it. But don't be so embarrassed that you don't go to the emergency. Go quick. And if you don't want to go to the ER because you were cheating on your wife.

Go the ER anyway. In the next tail. Prevention is right, go to the next tab. Prevention is key. Just don't do that position. So you should always seek medical attention if you experience bruises on the penis. Correct. Yellow, green, or otherwise unusual penile discharge.

Swelling or inflammation of the penis. Blisters, rashes, warts, or sores on or near your penis. Yeah, don't ignore that stuff. Burning, pain or bleeding when you urinate or ejaculate. Pain during sex, pain during an erection, and difficulty getting or maintaining an erection. She's doing this on purpose. Every guy listening to this has got their legs crossed right now with their hand on their chuck going. I mean, I just think it's a really, like, low-level first grade article.

I feel like every man knows this stuff already, but they always like to talk about their penis. So there you go. There's your little present for me. Yay. Hey, Steve, I have a question. Okay. I just got a text. Okay, so if you are giving Paxlovid, if you are given Paxlovid, and you are lactose intolerant.

Okay. Because Paxlovid has lactose in it. Okay. Does it have enough to, like, really bother you? No, and the thing is, is that even if it did, you can take an enzyme, you know, called lactate. And it would be worth it to help the medicine. Here's the thing. So they are, I'm looking at the contraindications to this,

who may not be able to take Paxlobin, pregnant, allergic reaction to Paxilobin, kidney problems, liver problems, intolerant to lactose or galactose. Neur matrilier contains a lot of lactose. Have a lactase deficiency or glucose galactose malabsorption? Here's the thing. Tell your primary care about it, and we'll see how severe it is. Yeah, it has a lot, but it's, here's the thing with Pax Lovad.

And I get into it with people. Well, 20% of people have rebound, and, you know, Fauci took it, and he had rebound and say, okay, no one ever said Pax Lovad was going to keep you from getting sick. and that the Paxloved keeps you from going to the hospital and keeps you from dying if you're at high risk. So if you are someone with HIV, for example, or sickle cell or chronic kidney disease, or you are in a high risk group, down syndrome, organ transplants, any autoimmune or inflammatory conditions, anything like that. been age greater than 65, morbid obesity, diabetes, those people are at risk. Now, of that whole set of people that are at risk, a small minority of those are going to

end up in the hospital and end up dying. It's a very small number. But this will prevent 90% of that. So you're preventing 90% of a very small number. So you have to select your patients. And there are other drugs, tastes, or there is another drug, Molinopiravir. can be given to people who can't take Paxlovit. It's not as good as Paxlovit as far as preventing hospitalization or death,

but it's better than not taking anything. It is very well tolerated. So the lactate should help, though, correct? I would think the lactate would help, but you've got to talk to your primary. This is in the U.K., so they're saying that it is contraindicated. I have not seen that in the, in the patients, as far as warnings when I prescribe this stuff, because I have a lot of patients with, you know, cancer who end up with COVID-19, and I'm called on to treat them. So I'm looking here to see if there is anything on the American side.

Okay, here's drug topics. Can lactose intolerant patients use this stuff? Oh, come on. Give me an answer. I probably should have just stopped the recording. Okay, it says here, in summary, it appears most patients who are lactose intolerant can probably tolerate the quantities of lactose that are incorporated into these oral drug products. Highly sensitive patients may have issues with it.

So you have to know your body and just talk to your primary care. But, yeah, the nermaltravere does have a lot of lactose in it, which is interesting. But, I mean, I wonder compared to a block of cheese or, you know, a bowl of ice cream, how much does it really have? You know? I don't know. Well, if it's lactose intolerant, that's different than having Crohn's or something like that. Yeah. You know what I mean?

Yeah. Yeah. Right. The problem is this person cannot get their primary care right now because of the holiday. What, oh, because of Martin Luther King? Yeah. Okay, so then let's just do this. We're going to take a second.

We're going to look it up on the Paxlovid package insert. It says Paxloid contains lactose. Patients with rare hereditary problems of galactose intolerance, total lactase deficiency, or glucose galactose malabsorption should not take this medicine. The levels of lactose within this preparation should not routinely preclude the use of this medication in those with galactosemia. So they contain less than one milly mole per dose that is to, oh, that's sodium. So they're basically sodium-free. So, you know, if they just have run-of-the-mill lactose intolerance, they should be able to take it. But again, I'm going to couch that by saying they need to talk to their primary care.

provider. Okay. Does that help? Any questions in the... Yes, and there should be also be a provider on call. Yes, of course. Yeah, there's pretty much required to be a provider on call. We have any questions from the fluid family, Dr. Scott, because I've got a couple of voicemails.

No, let's do it. Let's do it. Okay. All right. Oh, wait a minute. Wait a minute. I want to do this one. This blows my mind. Surely to God we didn't do this. Copper and magnetic bracelets have been proven wrong repeatedly

by every scientific study and the fact that you're entertaining it on your show is pretty hilarious, thank you. Do you remember us ever entertaining copper or magnetic bracelets on the show? I've debunk that shit. Oh my gosh, that's been so long ago. I've debunk that shit a million times on this show.

What does the fuck is he talking about? No, I think we talked about one time and the only thing we said was they feel good and they probably increase blood flow as far as 16. I don't even agree with that. Yeah, well, but as far as increasing... That's a Dr. Scott.

Yeah. Well, as far as healing anything, I don't think so. Well, no, the magnetic fields don't even penetrate the body and the copper on the outside. What the f is that supposed to do? We've looked at studies on this show before. I think there's another Dr. Steve out there, and he's on like WPIX or something like that. And I think this person is talking to them because I don't... If it was us, I want to know what show that was and I want to review what we were talking about.

Because that one pissed me off. I sent a text back to him. I said, bro, what the hell are you talking about? All right. Let's see here. Hi, Dr. Steve. This is Steve from New York. I have a real question.

Yeah. What is the difference between Alzheimer's and dementia? Oh, okay. That's a good one. That's a good one. Thank you. Okay. So the set of all flowers fully enclosed.

closes the set of all roses, right? So if you look at your Venn diagram, you've got a big circle that says flowers, and then inside it is a smaller circle that says roses. Now, there's lots of other circles in there, some that say chrysanthemum, some that say peonies, whatever, vincas. This is analogous to that. The set of all dementias includes the set of all Alzheimer's. So all Alzheimer's patients have dementia, but not. all dementia patients are Alzheimer's patients. Right.

So Alzheimer's dementia has a specific sort of syndrome. It starts at stage one where the patient is somewhat eccentric. I told you about my professor in medical school that got dementia. And he had a thing called anomia, which is a classic early symptom of Alzheimer's dementia, where you can't name things. But he had an IQ of like 220. He was Marilyn Vossabon level, you know, IQ. And when he couldn't remember how to say deck of cards, he said a concentric stack of thin laminates.

Now, who would even know to say that? Nobody. I mean, that's why he was a genius. But anyway. And then they pretty much gradually marched through all the stages until, if they live long enough, the last stages they're curled up in a ball, just sort of making noises. And then there's vascular dementia, which goes in a stepwise fashion, little mini-stroke-like activity where the, you know, parts of the brain die because of bad blood flow, and they will be okay, and then all of a sudden they'll drop in function and they'll stay there, and then all of a sudden they'll drop in function some more. It's in a stepwise fashion.

Then you have other dimensions like frontotemporal dementia, or a.k.a. Pix disease. Picks disease is a fascinating thing where people will have a burst of creativity. Tase, if you start to see me all of a sudden, I can paint, you know, amazing landscapes and never could do that before. And then that could be a sign of Picks disease and they get more and more eccentric. Or also a sign of just you. Well, true. I mean, look around. It's great.

But I mean, you know, on that sort of pro level. Dilaton. I get good up to a certain point and then I just move on. But the, and that's the ADHD. You know, I just get bored and so I got a million hobbies. But then they will have trouble with their interpersonal relationships and then they'll start to decline significantly. So there's lots of different types of dementia. And Alzheimer's is one of those types. Okay. Does that help? Questions? Good question. Good question.

All right. Let's see here. Hey, Dr. Steve. Oh, we don't have time for this. We're going to do this one next time. It's a guy that has post-exercise paralysis, but we might have time for this one. Hi, Dr. Steve. How are you?

Good, man. How are you? Oh, I'm great. Hey, this is Matt from Chicago. Hey, Matt. In Chicago. Hi, everybody. Thanks again for being.

awesome with all the medical stuff. It's where they watch TV. So hopefully that's refreshing. Yes, thank you. I was curious. This phone call is actually from 2021, by the way. So, yes, it was quite refreshing at the time and still refreshing. You know, when my wife and I are partaking in spicy food, Indian food or whatnot,

she'll be fine the next day. And I have the Ring of Fire situation, you know, kind of, you know, scorched butthole. you know, kind of bad stomach issues, things like that. Yeah. I was wondering, why is that that she seems unfazed and I'm more sensitive? You know, what is that in certain people that can handle, they might not handle the taste, but they can handle it gastro-wise. It's more enzymes that they have.

They can process the spicy food or what. What's going on? He's very close. Thanks a bunch. Take care. Hey, thanks, man. The answer to this is some people are born with fewer receptors for cap. Capsacin.

Capsacin is the molecule that causes heat. We measure it in Scoville units. So you've got your jalapinis, which most anybody can eat. And then you've got your ghost peppers and Carolina Reapers and have these, you know, the Scoville units and the millions. And, you know, some people are just born with fewer receptors. And this makes them less sensitive to spicy foods, gives them a built-in tolerance for heat. And there is actually, the gene has been identified. It's called TRPV1.

It codes for a receptor protein that binds to capsacin, sends a signal to the brain to interpret the sensation as heat. And we know that this is true that the capsaicin isn't inherently hot because if you have squirrels get in your bird food, you can get capsicin-laden bird food. The birds can eat it. They don't even notice it. The squirrels, it'll chase them off. Wow. Yeah, they'll eat one and go. going back to that place.

Wow. I didn't know that. Yeah, now people with a certain variant of the TRPV1 gene experience a stronger burn from capsation than those without it. And receptors can change over time. So you may be able to build a higher tolerance to hot and spicy foods, which we know that's the case. You know, if you eat more spicy food,

you're going to be able to tolerate it better. But in my case, there are certain spices that mess me up. You know, I can eat ghost pepper stuff. My Tabasco sauce that I ferment and make it to sauce is pretty hot, but I can tolerate it. I can take as much of it as I want.

But there are certain, like if I go to the Indian restaurant, it just kills me. I love Indian. And I can feel it working its way down through my gut. And I'd love to know which particular spice is hurting me. It may not be the pepper. You know, maybe something else. But I can feel it like it starts in my stomach.

Then the next day I can feel it in my small intestine. And then I feel it in a large bowel. It's horrendous. It's just a, you know, a sharp sort of burning pain. So, yeah, we're all different. You know, I mean, you've got a continent of a billion people that can eat that stuff just fine. And there's dumb old me can't tolerate it. Anyway, all right, you got anything else?

You got anything from the fluid family now? Dr. Scott? No, I'll remember it. Okay. They've been pretty, uh, fluid family. chilling. They've been pretty chill today. Well, thank you all. Thanks, always go to Dr. Scott. Thanks, Tacey. Thanks, everyone who's made this show happen over the years. Listen to our Sirius XM show on the Faction Talk channel, Sirius XM, Channel 103, Saturdays at 7 p.m. Eastern, Sunday at 6 p.m. Eastern on demand and other times, a Jim McClure's pleasure. Many thanks to our listeners whose voicemail and topic ideas make this job very easy. go to our website at dr steve.com for schedules, podcasts, and other crap.

Until next time, check your stupid nuts for lumps, quit smoking, get off your asses, get some exercise, but see you in one week for the next edition of good medicine. Thanks, everybody. Goodbye. You say you'll never join the Navy, that living on a submarine would be too hard. You'd never power a whole ship with nuclear energy. Never bring a patient back to life.

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