Young and Profiting with Hala Taha - Dr. Mark Hyman: How Entrepreneurs Can Reverse Aging and Unlock Peak Health | Mental Health | E349

Episode Date: May 5, 2025

Dr. Mark Hyman isn’t just focused on aging; he is committed to thriving throughout life. In his sixties, he co-founded Function Health, a startup dedicated to optimizing biological health and wellness for peak performance. In this episode, Mark discusses the power of functional medicine in unlocking longevity, the secret to aging backwards, and small, daily changes that can improve health, boost productivity, and lead to a longer, more fulfilling life. In this episode, Hala and Mark will discuss:  (00:00) Introduction (01:10) The Science of Aging and Longevity (06:27) How Functional Medicine Optimizes Health (12:02) Functional Medicine vs. Biohacking (14:37) The Secret to Aging Backwards (19:23) The Role of Diet, Sleep, and Toxins in Aging (27:23) Living a Life of Purpose and Career Fulfillment (29:33) Navigating Modern Food Challenges (35:22) Why Your Social Circle Matters for Longevity (40:58) Practical Wellness Strategies for Entrepreneurs Dr. Mark Hyman is a family physician, author, and educator, transforming aging and disease prevention through functional medicine. He is the co-founder and Chief Medical Officer of Function Health, a platform providing personalized health insights through comprehensive data analysis. Mark is also the founder of the UltraWellness Center and the Cleveland Clinic Center for Functional Medicine. Sponsored By: Indeed - Get a $75 sponsored job credit at indeed.com/profiting Shopify - Sign up for a one-dollar-per-month trial period at youngandprofiting.co/shopify Microsoft Teams - Stop paying for tools. Get everything you need, for free at aka.ms/profiting Mercury - Streamline your banking and finances in one place. Learn more at mercury.com/profiting OpenPhone: Streamline and scale your customer communications with OpenPhone. Get 20% off your first 6 months at openphone.com/profiting Mercury - Streamline your banking and finances in one place. Learn more at mercury.com/profiting  Airbnb - Find yourself a co-host at airbnb.com/host Resources Mentioned: Mark’s Website: drhyman.com  Mark’s Book, Young Forever: bit.ly/YoungForeverBook  Mark’s Podcast, The Dr. Hyman Show: bit.ly/DrHymanShow   Active Deals - youngandprofiting.com/deals   Key YAP Links Reviews - ratethispodcast.com/yap  Youtube - youtube.com/c/YoungandProfiting  LinkedIn - linkedin.com/in/htaha/  Instagram - instagram.com/yapwithhala/  Social + Podcast Services: yapmedia.com  Transcripts - youngandprofiting.com/episodes-new  Entrepreneurship, Entrepreneurship Podcast, Business, Business Podcast, Self Improvement, Self-Improvement, Personal Development, Starting a Business, Strategy, Investing, Sales, Selling, Psychology, Productivity, Entrepreneurs, AI, Artificial Intelligence, Technology, Marketing, Negotiation, Money, Finance, Side Hustle, Mental Health, Career, Leadership, Mindset, Health, Growth Mindset, Mental Health, Psychology, Motivation, Mindset, Manifestation, Brain Health, Life Balance, Self Healing, Positivity, Happiness.

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You want to live to be 120 years old. Why do you actually want to live so long? I love life. What is the definition of health? It's not the absence of disease. It's something else. How do we unlock the keys to optimal biological performance? I've spent 40 years studying the science

of the function of the body. Frailty is not a normal consequence of aging. It's a consequence, a phenomena that happens as we get older if we don't do something about it. We have dysregulated sleep schedules. We have tremendous amounts of stress. We eat crappy food. we don't do something about it. We have dysregulated sleep schedules, we have tremendous amounts of stress, we eat crappy food, we don't exercise enough.

There's all these things that we're doing to impede our ability to actually live a vibrant, long, healthy life. What did you do to reverse your age 20 years? I have been eating. Let's say you gave you a 35-year-old, they're stressed, exhausted, running on coffee. If you had a year to transform their health and performance,

what are the things that you would change? I would immediately have them get it. Yeah, fam, imagine feeling stronger, sharper, and more energized as you age. Not the other way around. Well, today's guest is going to help teach us how to just do that. Dr. Mark Hyman is a leading functional medicine expert and the bestselling author of books like Young Forever and Eat Fat Get Thin. He's going to share some science-backed insights to help you improve your health, extend your lifespan,

and defy aging. But first, make sure you follow and subscribe to Young and Profiting Podcast. Whether you are a frequent listener or a brand new listener, make sure you're subscribed to the show. That way, you'll never miss an episode packed with expert insights like this one. Mark, welcome to Young and Profiting Podcast.

Well, thanks for having me. I'm so excited for this conversation and there's so much to talk about, but I just wanna jump in and get started. So I was reading your book, I was researching you, and I found out that you wanna live to be 120 years old. Well, if I can do everything I love to do, yes. If I can, no.

I'm still riding my bike at 119, I'll keep going. That would be amazing. I also interviewed Dave Osbury a few times and he tells me he wants to live to be 180 years old. So there's this trend of biohackers like you guys that wanna live to be 120, 180 years old. I would just say I'm not a biohacker. I'm a functional medicine physician.

And so I use deep science. Some of the tools are similar but functional medicine is really the ultimate biohack. Yes and we're going to talk all about functional medicine and I'm going to try to help my listeners understand what that is if they're not familiar. But you guys are on a quest to live as long as you can right? So that's the two things that you guys have in common. Maybe it's not biohacking. Right. So that's the two things that you guys have in common. Maybe it's not biohacking. But when I think about that, I think about frail, old, bedridden. I don't really want to live to be 120 years old, at least by today's standards.

So I want to understand when you imagine yourself at 120 years old, what do you actually imagine yourself being capable to do? What is 120 year old and thriving look like? I mean, it means being able to do whatever you love to do. If it's sitting there rocking Jeremy to book, it's that. If it's hiking up the mountain, it's that. If it's making love with your partner, then it's that. So for me, it's really being able to get up in the morning

and do what you love to do and not be encumbered by some of the conditions that are mostly preventable that we seem to think of as normal of parts of aging. They're not really. And what's happening on the science is quite exciting. We were seeing a lot of research, for example, there's a Washington Post article recently about the almanac factors, which is basically a scientific discovery that won the Nobel

Prize that allows you to reprogram your genes back to a younger you. It's called epigenetic reprogramming, and it's being researched by the Altos lab, the Chepizos, and also by Sam Almond's lab. So there's a lot of really amazing research going on in this right now in the longevity space. That's going to be an unlock. For most of us, I think we can expect to get to our 90s or be 100, bigger us in good health if we know what to do to take care of our bodies.

And I saw this all over the place. I was in Sardinia and I was in Icaria. And I just saw people who are like really old and really thriving. And this woman was like 87 years old and she was like running up and down the side of this mountain. I couldn't keep up with her.

She was tending to her giant gardens and farm and animals and trees. And it's quite amazing to see. So I think if we understand the things that impede our health, we can remove those and we understand the things that enhance our health, we can add those. And it's really not that hard. It's just knowing what to do.

So I was listening to your audio book, Young Forever. It was really entertaining. And you were talking about how you went to Sardinia and went to the blue zones, but talk to us about what actually sparked your interest in longevity. I've always been interested in the science of optimization in terms of how we function, whether it's the word functional medicine or the company I co-founded Function Health.

The core value is how do we unlock how to function at your best and how to unlock the keys to optimal biological performance. And it's really something that we're now only discovering. No one's really asked the question in medicine before. What is the definition of health? It's not the absence of disease, it's something else. And if you go to your doctor, you feel good, say I wanna feel better, I wanna optimize my health.

They don't know what to do. Like if you have symptoms, great. If you have a disease, they'll give you a drug. But do they understand the science of creating health? No. That's what I've spent my life studying after medical school, the science of creating health. And it's something we now know how to do. And that's what's so exciting.

We know the basic biological systems at GORI. In the field of longevity, the science is really getting exciting because we're talking about these concepts called the hallmarks of aging. The hallmarks of aging are these fundamental biological things that go wrong or break down as we get older that are underlying all disease. It's like the roots or the trunk and all the branches and the leaves are all the diseases and all the specialties.

So it is heart disease or cancer or diabetes or Alzheimer's or whatever it is, autism, depression, they share common roots. And there are only really a few things that impede health. You have to identify what those are. There are toxins, there's allergens, there's microbes that change your microbiome stress, physical or psychological stress, and poor diet, which is most of us eat. And then there's a few things that our bodies need to thrive. So you need to get rid of the bad stuff and put in the good stuff. And then there's ways of even accelerating the optimization of things,

for example, like how do you optimize your mitochondria? How do you optimize your microbiome? How do you optimize neurotransmitter function? How do you optimize your immune system? These are things that we now know how to do. If you say to your doctor, I want to optimize my mitochondria and figure out how to optimize my immune system. And they're not going to know what to do. How do I optimize my microbiome? Take a probiotic, you know, eat fiber. They're not gonna really understand because it's not what they do. And I've spent the 40 years studying the science

of the function of the body. And that's really what we have come to in terms of understanding how to create these shifts in our biology that create abundant and vibrant health and that don't provide a breeding ground for disease. So with traditional medicine, really they're focused on a specialty, right? They don't treat the whole body holistically. So can you give us an example of, okay, I go to the doctor and I'm like, hey... I'll give you an example. I'll just tell you a patient, actual patient I had,

I'm not going to use her name, but she was a business coach by 50 years old. She was overweight, she had prediabetes, she had depression, she had migraines, she had reflux, she had irritable bowel bloating, she had terrible psoriatic arthritis, which is a horrible condition where you get psoriasis all over your hands, skin, and body, and you also get arthritis, which is debilitating. So she was on a drug for that that cost $50,000. She was seen by the best docs, one of the best healthcare centers in the world, and she was getting the best GI treatment for reflux, the best treatment for irritable bowel, the best treatment for depression, one of the best healthcare centers in the world. And she was getting the best GI treatment for reflux, the best treatment for irritable

bowel, the best treatment for depression, quote, the best traditional view, the best treatment for migraines, the best treatment for her pre-diabetes, the best treatment for her psoriasis arthritis. And she was seeing a doctor for every inch of her. And no one said, what is linking all these problems together? For her, it was inflammation. She had tremendous amounts of inflammation that were driving all these conditions. Now, we know that depression is inflammation, right? We know that if your gut's upset, it's inflammation. We know that obviously if you have inflamed

skin and arthritis, that's inflammation. We know that diabetes is inflammation or pre-diabetes or obesity is inflammation. So I said to myself, well, what did the root cause for her? She was having so many gut issues that I believe those are the cause. She had severe bloating. She had all these history of taking antibiotics, the steroids for various things like for her autoimmune condition. And I said, why don't we just do something really simple? Rather than taking all these drugs, you can continue to take them. But in the meantime, let's just try you on a whole foods, low sugar, low starch diet, which removes the common inflammatory triggers.

For my practice, for people who have autoimmune disease, getting rid of grains and beans, dairy, gluten, which is part of the grains, sugar, processed food, alcohol, really makes a difference. So I said, put her on that diet. I said, let's kind of reset your gut. I gave her an antibiotic and an antifungal to reset her gut. And then I gave her probiotics and things to rebuild her gut. And I gave her vitamin D and some fish oil, not a lot of stuff. And six weeks later, she comes back,

she says, Dr. Hyman, I got off all my drugs. I'm like, wait, I didn't tell you to do that. She said, no, I just was feeling so good. I stopped everything. And she had no more seroactin arthritis. Her skin cleared up. She had no more migraines. She had no more depression. She lost 20 pounds. Her pre-diabetes was gone, her reflux was gone, her irritable bowel was gone. And so I just treated the root cause, not the symptoms. Inflammation is a common trigger for most chronic diseases. And for me, after seeing this for 30, 40 years of patients like this, I can see it when they walk in, I know that it was going on.

And it's not that hard to treat, but she was getting all these symptoms suppression treatments that weren't really working. They were marginally working, They were keeping her functioning, sort of, but they didn't really deal with the problem. So functional medicine is about really understanding the body as a network, as a system, as a system of systems that you have to keep optimized in order to live well. And they map almost entirely perfectly across the hallmarks of aging that scientists ever discovering. So when your mitochondria don't work, when your detox system doesn't work, when your immune imbalances or hormone imbalances or neurotransmitter balances or your guts off,

these are things that we know actually know how to treat. Your mitochondria aren't working. These are things we know how to treat with functional medicine. And talk to us about how your company function services these types of problems. What we've done with function is really create the first health platform that allows people

to fully access their own data. Now people are wearing O-R-Rings, they're wearing Apple watches, they're wearing glucose monitors, that's all great. That's just a few data points. But what if you could unlock all of your biology? What if you could know all your biomarkers and your metabolome and your microbiome and your genome,

imaging, your wearables and your medical history and your genome, imaging, your wearables and your medical history and your EMR, your medical records, all gets into a platform that is personalized to you and allows you to identify where the imbalances are, where the dysfunctions are and gives you deep insights and content based on machine learning AI to help you actually optimize your health for you. Because no two people are alike, and everybody's different. And if we try to treat to the mean, we often miss the mark.

And this is what medicine does, it treats to the mean. There's no average person, right? Everybody's different. And the studies work by something called randomized control with all blind trials, which means you basically have two populations that are as identical to each other as possible. So you wanna be a 70 kilogram white male from Kansas, and you get 100 of those people,

you put 51 group and 50 other group, and you give them a drug, you see what happens at the other side. That's how medicine operates. That 70 kilogram white male is not like 90% of us out there. Not you, it's not me. And so how do we move towards where medicine is going, which is personalization? We call precision medicine, personalized medicine, whatever you want to call it, it's where we're going.

And so Function Health is the first platform that is able to actually do this for you in an amazing way that helps people revolutionize their health. And we just started, honestly, this is a startup, and we didn't realize how much success we were going to have. And so we have almost 150,000 members. We have millions, tens of millions of data points on people. We're seeing all kinds of trends in the data. We see that people actually, when they get their first test, and now we've been going

two years, we can see that when they follow up and do the follow-up testing, that their biomarkers get better, their blood sugar gets better, their cholesterol gets better, their inflammation gets better, their vitamin D gets better, whatever is off. And we give them a deep dive into what's going on with their biology, not just from a traditional perspective, the traditional sort of Western medical perspective, but also this emerging field of systems network and medicine, which is what functional medicine has been doing. But now the rest of the science is catching up, which is very, very exciting to me. Let's hold that thought and take a quick break with our sponsors. This episode of Young and Profiting is brought to you by Mercury,

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So my first question to you, I mentioned biohacking and you got like a little offended when I tried to compare what you were doing with biohacking. But when I hear you talking about it and you're talking about personalization and figuring out your biological age, to me that's, you know, I've been doing this podcast for six years and had a lot of people on the show and it sounds a lot like biohacking. So what's the difference? Well, I think biohacking tends to be running like hot and cold plunges, hyperbaric chambers, red light therapy, all these devices and tools and things to optimize your health, which

are fine. They work and they're mediated by biological processes and I use those. However, if someone comes in like that woman that I just described to you, no biohacker in the world is going to fix her because they don't understand the science around functional medicine. Now, if they're a trained practitioner, fine, they'll figure it out or hopefully they'll figure it out. But when you just use these modalities without trying to understand what the underlying cause

is, it's another symptomatic treatment. You might feel better for a little bit. You go on a sauna, You go on a cold punch. You feel good. But then what? You still have your arthritis. You still have your autoimmune disease. You still have your migraines.

You still have whatever you got. And no one's telling you how to figure out the root of that. So I'm not opposed to it. And Dave's a good friend. And I love Dave Asprey. And we hang out and talk all the time. And I learned from him. And there's all kinds of great tools that I personally use and have.

I'm just saying that functional medicine is sort of the OG biohacking in a sense, because it's really about understanding much deeper level what's going on biologically, biochemically, genetically, you know, your microbiome and ways that I think most people just, it's a lot to take in. And the problem is, you know, there's 37 billion billion chemical reactions in your body every second. Nobody understands all that. And you have tens of thousands of metabolites in your blood and chemicals. We do 19 on a regular panel. With Functional Health, we do 499,

which is $15,000 to test for less than 500 bucks. And you get over 110 biomarkers, and you can add on other things as well to go deeper dives into whether you're exposed to chemicals, whether you're at Alzheimer's risk, whether you have immune issues. I mean, so whether you have Lyme disease. We provide you a really deep, robust platform whether you're having immune issues. I mean, so we have Lyme disease, we provide

you a really deep, robust platform where you get to be driving the bus. You don't have to go to a doctor, you don't have to ask for permission, you don't have to beg for the requisition, you don't have to go to the, try to find a lab that will order you to get your insurance to pay for it. I mean, I have insurance, I go to the lab, my doctor ordered some stuff that I wanted to do. And it was outside of function. And she said, well, it'll pay for this test, and this test, and

this test, and this test, you want to be charged for that, and you'll be charged. I she said, well, it'll pay for this test, but not this test, and this test, but not this test. You want to be charged for that, you'll be charged. I'm like, oh, you know, it's like, but that's what function solves all of that. And you have this beautiful integrated dashboard where you have your data forever and you track it over time. You get an app which helps give you direct feedback and is a very integrated experience into your life. I feel like it's really needed because to your point, the rest of the medical world is kind of stuck in this traditional process that just really isn't working. And the other thing is that's not working is actually treating aging's symptoms and not the root cause. And one of the other big principles that

you talk about is treating aging like an actual disease. So why is that important? Well, I think you come to sort of accept that as you get older, you have cancer, you get heart disease, you get older, you have cancer, you get heart disease, you get diabetes, you lose muscle, your brain function declines, you lose your ability to do things. These are not normal consequences of aging. Frailty is not a normal consequence of aging. It's a consequence, a phenomenon that happens as we get older if we don't do something about

it. And all of us have seen those 90-year-old ladies doing like gymnastics and 100-year-old people running the 100-yard dash, you know, it's kind of crazy stuff like that, right? And what is it about those people? Well, they have understood by accident or by studying that there are certain behaviors that foster optimal health. It's eating whole foods, unprocessed diet, it's low sugar and low starch and full of phytochemicals and fiber and got it with amounts of protein, especially more animal proteins

as you get older because it's harder to assimilate and build. You need to make sure you exercise and do strength training and you need flexibility, you need cardiovascular training and stability training. They understand you need good sleep. They understand they have managed their stress and their own emotional regulation. And they also have deep social connections and relationships that foster a sense of belonging, which are all our ingredients for optimal health. And when you look at people like the in the blue zones, that's basically what they have.

It's not that they were vegan or not vegan. It was that they had these other factors and that they were profoundly impacted just by default by these situations that they found themselves born into, which we totally in the West don't have. We're the opposite. We have dysregulated sleep schedules. We have tremendous amounts of stress. We eat crappy food.

You know, we don't exercise enough. My heart rate told me I didn't exercise enough yesterday. I was like, I'm busy day. So, you know, there's all these things that we're doing to impede our ability to actually live a vibrant, long, healthy life. Well, you seem to be doing a good job because your biological age is 43, but you're in your 60s.

Is that right? Yeah. Well, I got my biological age done when I was 62 and I was 43. Then I implemented more of the things that I learned and some other strategies. I got two years older, I'm 64, and I redid my biological age, I was 39. Even though I got two years older chronologically, I got four years younger biologically.

So that's the power we have, epigenetic reprogramming. Now, I mentioned earlier the Amanaka factors and so forth. These are sort of kind of sky things that have to be tested in humans and make sure they're safe and effective. But right now, even with what we know by optimizing and tweaking, you can actually still reverse your epigenetic biological age at any point in your life. It can go backwards or forwards. If you kind of go on a bender or whatever, you don't sleep, you party, and you eat crap food, you'll get older biologically. And then you can change that

and reprogram and go back. So give us concrete things. What did you do to reverse your age 20 years? Well, I've been doing this my whole life. So it wasn't like I was 64 biologically and then I, in five years, I reversed that to 40. So I have been eating whole foods my whole life. I've been not eating processed foods. I don't remember the last time times I haven't had a soda. I mean, I probably was a kid. I exercised my entire life for the last 50 years. I've made sure I prioritize community, connection, sleep, and manage stress. And all those things play a role. And then I've done things to optimize my microbiome, my mitochondria, my immune system. And those will all really help. So all those things kind of nudge you back into a healthier state.

And there's some supplements and things that I've taken that I think have made a difference. I've taken NeuroLithin A, I take amino acids that should help be assimilated. I also take something that's called NMN, which is a precursor of NAD that helps also revitalize your cells. I do a number of different things that I think are important from a supplement perspective, but I think most important from a supplement perspective, but I think most of it's like the 10%,

the rest of it is the 80 to 90%. And that's what, if we were to use function, the platform, it would help us figure out, okay, what's our biological age? And then these are the things you need to do related to functional medicine to help. That's what it does. Yeah, yeah, we do a calculation based on your biomarkers of what your biological age calculation based on your biomarkers

of what your biological age is based on scientific data that shows certain blood biomarkers correlate with your epigenetic biological age. And you can see it go backwards or forwards. Now, if you do different tests, you're gonna get different numbers, right? Some tests will be like five years younger or 10 years younger.

You may not be able to compare apples to apples by switching tests, but if you stay with the same tests consistently, you'll see the changes. So I want to get really nerdy because I'm sure people have been listening and they're like, I have no idea what epigenetics is. And so there's two terms I want you to break down, epigenomes and exposome. So one is about how our genes are expressed. One is our environmental exposure.

So break those down. Yeah. So basically, there's a concept that I think is really important called the exposome. We all have been taught that our genes control who we are. They, they're our destiny. Whatever we got, we got, we can't change it. You know, our parents got diabetes, our parents got cancer, our parents got whatever heart disease. It's just in our future. Your genes are not your destiny.

They may provide you with a roadmap of what your predispositions are, but not your destiny. So what controls your destiny. They may provide you with a roadmap of what your predispositions are, but not your destiny. So what controls your destiny? It's something called the exposal. That is a sum total of everything that you're exposed to throughout your life that washes over your biology, including your genes, and reprograms them based on what you're doing. If you're eating, like me, if you had a whole foods diet, if you exercise, you do all these things, for 50 years, you're gonna be biologically younger. Your epigenetics are going to track as if you're younger.

And I'll talk about what epigenetics are. So the exposome is what you eat, it's your exercise, your nutrient levels, it's stress management, it's community, it's sleep, it's all the things we've just talked about, light, air, water, all those things. I went out in bright sunlight this morning for 20 minutes. All those things matter. That influences how your biology is regulated. We're biological

organisms and we're controlled in the same way by our external factors. So the exposome is literally everything from toxins to your gut microbiome to your diet to sleep, everything that your body is exposed to. That's why we call it the exposome. Your epigenome is how the exposome regulates your biology. Now what is the epigenome? Epi means above. So you've got your genes, you've got about 20,000 genes. Your epigenome, think about like the keyboards on a piano, right? You got 88 keys, they ain't changing.

You know, I got 20,000 genes, they ain't changing. Unless I do gene editing or splicing or some other weird thing that's coming around the corner, they ain't changing. Unless I do gene editing or splicing or some other weird thing that's coming around the corner, they're not changing. What can change is how those genes are expressed, how they're turned on or off, whether they're upregulated or downregulated, whether they drive inflammation or stop inflammation, whether they're accelerating aging or slow aging,

and they are basically the control mechanisms to turn on or off genes. So think of them like switches or knobs, and you can dial them up or down based on what you're doing. And that's how almost all of the impacts of a lot of the lung practices we talked about have their effect.

That's how the exposure regulates your health and lungs, having your biology and your risk of disease is through your epigenome, then translates into the expression of genes and proteins and biological functions, and you want to have a healthy epigenome. There was a great example, for example, a brand new journal has discovered this phenomena was these mice that are bred to be obese. So they're yellow, they're fat, basically yellow fat mice. He gave a series of the females who are pregnant certain nutrients

called methylated nutrients that regulate the epigenome. It's a little complicated, but there's something called methylation, which is a chemical process that regulates your genes. It involves B6, folate, and B12. So vitamins and minerals are extremely important. They run everything in your body. Every biochemical reaction needs a vitamin or mineral. And if you don't have them or they're insufficient, you're going to have gummed up biochemistry. And gummed up biochemistry translates into disease. So he basically gave these pregnant mice some B vitamins and a few other amino acids and things

to help to support this process. The offspring were perfect. They were thin, they were healthy, they were gray. They were not yellow fat mice. Even though genetically, they were bred to be yellow fat mice. And this was a massive discovery. And I think this is what really has led to our understanding of this whole process of how we can modify our epigenome and the outcomes. So when your mother's

eating, when she's pregnant with you, the stresses you experience in utero that your mother might have experienced, or all your early childhood experiences, all those imprint on your epigenome and can affect you, toxins you're exposed to. So this is why we have to sort of pay attention to how we live because if we want to feel good and do good and engage in life and do the work we want to do and be successful in our work and have great relationships and enjoy life and be happy, if you feel like crap, it's not that much fun. So true. And so from what I read, 90% of disease and aging risks has to do with our environment, our exposome, right? Yes. So the earlier that we start, the better is what you were just saying, right? We can even start from in the womb if our mothers are smart enough. Yeah, you know, I've seen women wanting to be pregnant.

I measure their toxin load. I'm like, whoa, we got to do something about this. We got to reduce your exposures of toxins. You've got to get these heavy metals down because you want an healthy baby. And so we really proactively do preconception work. I had a whole podcast about that on the doctor's pharmacy. And now it's called the Dr. Hyman Show.

You go deep into what you need to know preparing for a baby, what happens when you're pregnant, how do you take care of yourself, what are things that are matter scientifically to optimize the chance of having a healthy baby. On the flip side, is there any time that's too late to get started on this? Oh god, no. What's really amazing, in one of the animal studies, they've given rapamycin, which is something that is a drug discovered in Rapa Nui that inhibits this pathway called one of the longevity switches, I call them longevity switches, that control so much. So mTOR is one of these.

And mTOR essentially is a pathway that is going to help you build muscle, but also when it's activated and when it's inactivated or inhibited in some way, it's going to allow the cells to replenish and repair through this process called autophagy, which basically means you're eating your old cells and you're reusing the parts. It's recycling. So it's cleaning up the mess that we make all the time in our bodies.

Where does that garbage go, right? Somebody has to fix it. So rapamycin inhibits that and accelerates the autophagy process and didn't give it in the right ways. It extends life and extends health in animal models consistently and reliably. And so there are interesting ways that we can sort of activate these longevity switches

and pathways. And I've talked about that a lot in my book, Young Forever, and how do we understand how these work, what we can do. And it's not complicated. There's a few simple practices, sometimes a few supplements that can really help modulate some of these pathways that activate the longevity switches. Okay. So one more really nerdy question and that's about mitochondria.

So you say the difference between a three-year-old and a 90-year-old is the number and the state of their mitochondria. So help us understand what mitochondrial dysfunction has to do with aging. So this is one of the hallmarks of aging is mitochondrial dysfunction. It's key to so many diseases.

Your mitochondria, think of them as like the powerhouse of your cell, the energy factories, they take food and oxygen, turn it into energy that your body uses. We use gasoline or carb and it combusts and creates energy. We run on something called ATP. It's a molecule produced from food and oxygen. The waste products are carbon dioxide, which we breathe out, and water, which we pee out, and some free radicals, which we have antioxidant mechanisms to control. And what happens is they're your energy, right?

So if you have poor functioning mitochondria, you're going to have low energy. You're going to be weaker, you're going to have lower muscle mass. So the key to longevity is keeping your mitochondria healthy and keeping them strong and actually having better, more mitochondria. And so the way to do that is by exercise. So resistance training builds muscle and mitochondria. And so the way to do that is by exercise. So resistance training builds muscle and mitochondria. Sprint training or training does that as well. Exercise with oxygen therapy, hypoxia training does that. A lot of ways to do it, there's supplements like

urelofen A, which is caused by topogy and mitochondrial renewal. Their mitochondria will support supplements sometimes that you need. So there are a lot of ways to optimize your mitochondria, but they're injured by too much food, too much sugar and starch, too many environmental toxins, all those things with microbiome that are bad, all those things can damage your mitochondria. So learning about your mitochondria,

how to take care of them is really important. And again, it's one of the things we can look at as we start to test things and see what's going on in our bodies. We'll be right back after a quick break from our sponsors. This episode of Young and Profiting podcast is brought to you by Mercury, the modern business banking experience that brands like mine use to manage their finances.

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Sign up for your $1 per month trial period and start selling today at Shopify.com slash profiting. Go to Shopify.com slash profiting. Go to Shopify.com slash profiting. That's Shopify.com slash profiting. I wanna talk about your drive of wanting to live so long because one of the factors that you mentioned is having a purpose and feeling like you've got a way to contribute to the world.

So why do you actually want to live so long? Well, I love life. And as long as I can enjoy life and be with my friends and do the things I love and ride my bike and hike and enjoy what I'm doing and have meaning and purpose and contribute to the world and add value. I'm 65. I kind of figured a few things out by now. And wisdom always doesn't come with age, but I've had a bunch of hard knocks

and that's really taught me a lot. And so I kind of feel happy and content and satisfied. And like, I want to keep going. I mean, I don't really care if I get to 120 or 100 or 99 or 95 or 90, I just want to feel good and do good. I'm really excited for this generation of six-year-olds because I just feel like in the past in your 60s it's all about retirement and I feel like a lot of people right now are actually like taking on second careers and realizing that they really have a lot more time to live

and people are taking advantage of that. So like what are your thoughts in terms of people around your age who like want to take on a new career? Yeah. Tell me about that. I'm 65 and two years ago, I co-founded a company that's a big startup company right now. So who does startups in their 60s? Most people are like looking at golf courses and not startups. I mean, I want to contribute to the world. I want to do things. I get excited. We're building, we're creating, we're dreaming, we're imagining a different future for healthcare and medicine. We're adding value to people's lives. It's something to get up for every morning and be excited about and take all the things

that I know that are almost impossible for any single doctor to synthesize and to sort through and make sense of and provide each individual with a personalized approach to their health that's going to actually optimize how they feel. And that's really the key here is to end needless suffering. And for me, that's my purpose and that's my mission. And plus having fun, enjoying my life and my wife and everybody around me. It's hard for me to imagine at the same time,

I see people living older, but it's also hard for me to imagine, especially in the West, because I feel like things are more unhealthy than ever. The food in the grocery store is terrible. Everything comes in a cardboard box. Our water supply is really scary and it feels like there's no good water. It's either like you're getting plastic or you're drinking from a dirty faucet.

Right. And so for me, it just feels almost impossible to navigate food, which you say is medicine. So talk to us about how we should try to navigate our diets and what changes need to happen in America for us to actually live healthier lives and longer lives. This is something I've been working on for a long time. I wrote a book called Food Fix, which lays out from field to fork what's wrong with our food system. And if there's one thing that's killing us, aside from environmental toxins and stress in our same schedule, it's probably 80% foods. And it's something that we can control and do something about.

And unless we actually take it seriously and fix our food system, we're in a mess. And so right now, there's a resurgence of interest in health around the country. There's the Make America Healthy Again movement. And so there's that energy happening. And in Washington, working on policies that bring those changes to the average American. For example, in West Virginia, they got rid of red dyes and other dyes. In California, they do the same thing. These are great steps to start to push the food system to produce healthier food for all of us. And something that's really hot right now is GLPs, right? I have mixed feelings about them.

I'm not a doctor, right? But I think it's good if you have a real problem. But I see normal people who might just need to lose 10, 20 pounds take GLPs. So what are your thoughts around that? For most people, and I literally just got a text from somebody this morning saying, my cousin read your book, they lost 100 pounds. My person has worked with me in Washington around food policy, she lost 112 pounds in the last few years working with me, and without taking

any trucks. Now, some people are really stuck. And if you're stuck and you need help and you have not really addressed the underlying reasons why you're eating, it's not what you're eating, it's what's eating you. You got to figure that out. I think it's really important to do that. And I think when people do that, they don't necessarily have to take these drugs, which are helpful, they can be extremely helpful, but they also come with side effects, muscle loss, weight gain if you stop, they can have other issues,

you know, like pancreatic issues and pancreatitis, and they can cause bowel obstruction if taken for a long time. So they can be a good tool, but they're just a tool. They're not a panacea. And I think they've helped a lot of people. I'm not against them. I think they're used in ways that sometimes don't make sense to me. Why give a six-year-old an ozepic shot for the rest of his life?

It's not his fault he's overweight. It's the environment he's in. And I think that can actually get really fixed. So I think it's important for people to understand that they have power and that the food industry is basically a hijack to our brain chemistry and metabolism or desires for different foods. And these are things that can actually be changed.

You can literally change your brain chemistry and have an incredibly powerful shift in your cravings and your desire for foods. For example, people who go on keto, they don't really need OZepic because naturally the way they're eating will shut off that craving. And the food addiction is a real thing. About 14% of adults and kids are addicted to food, biologically addicted. This is really based on good evidence from the Yale Food Addictions Scale and deep science around the world. We looked at this, this is just horribly sad

and horribly unfortunate because we really don't need to do that. We can fix our food supply, we can fix this problem. And it has to be done at grassroots level, it has to be done at state level, it has to be done at federal level. It's gonna take time, but we're working with the FDA, working with the USDA, with HHS, the administration as best we can to try to push changes through by nonprofit.

I've also heard that there's food companies already trying to figure out how to circumvent GLPs so that people still crave their food, right? So this is going to figure out how to get around it. That's even crazier when you think of it. Like, wow, they're really just going to go there. They're literally going to just kind of circumvent Ozempic by making food even more addictive. Yeah, that's the state of the world that we're in. So we've got to take control. So let's talk about our ancestors. Because when I was listening to your book, I was surprised because we're always thinking about how we live so long now. And when you think about the past,

you might think people died at 30, 40, but there's actually cases in history where people have lived to be a very old age. So talk to us about how our ancestors ate and maybe some examples of people who lived really long back in the day. I think, you know, when you look, for example, at the Native Americans, one of the longest populations in the day? I think, you know, when you look, for example, at the Native Americans,

one of the longest populations in the world, at the turn of the 1900s, was the Plains Indians. They had most of their diet from bison, and then they had berries, and they had probably wild stuff they gathered. But predominantly their diet was meat, and they lived to be well over 100 and highly functional and active. And these populations around the world where you see people like I was in Turkey and they know this is not a technical blue zone, but man, they were a lot of really old people who are

doing great. Were in their 80s, 90s, still working, still thriving, still make part of their community. And I think it's when you stop, you stop. Like I think retirement is the worst idea ever invented. I don't really get it. But people don't retire, they just shift and change what they're doing. And I think these communities, and when you see these people living to be very old,

it's because they found meaning purpose. They've learned how to not sort of internalize the stresses of life. They've learned how to modulate their own diet and lifestyle to optimize their health and they just figured it out. Let's stick on community a bit because you say it's also a factor in longevity. You say you're only as healthy as your five closest friends.

Tell us about that. Well, think about it. If all your friends are going to McDonald's and drinking beer and truly it was a soda day and watching TV all the time, that's what you're gonna be probably like. And if you have friends who are healthy and go to yoga and drink green juices,

but exercise and eat whole foods and get together and share these things, you're more likely gonna be healthy. It's just so clear. Chris Stock has from Harvard did a lot of work on this, wrote a book called Connectivity, published research in the New England Journal of Medicine, showing that, for example, from the Framingham data, which is a large study, probably one of the

largest studies, longest-going studies in the world, in Framingham, Massachusetts, tracking their population, he found that those people who actually, when they looked at the patterns around obesity, that you were about 40% likely to go overweight if your parents or siblings were overweight, but you were 171% more likely to be overweight if your friends are overweight. So your social connections matter and your relationships matter. If you're somebody who just stands up all night playing video games and you're living in America and your friends are playing video games in Australia, I mean, your sleep-wake cycle, your circuitry rhythm, everything's going to be off.

So the people in the communities that you have to surround yourself with, make sure that people who are leaning in towards wellness and health as opposed to not that. That's so interesting. Now I don't want everybody tuning in to like become fat phobic, you know? But at the same time, you've got to pay attention to, it's the same thing, if people are like doing drugs around you, you're more likely to do drugs.

So food can also be as bad as a drug. We've got to think of it that way. So if there was one thing that you could remove from the grocery stores, what would it be? It would be high fructose corn syrup. Like that, you'd cut out most of the in the grocery store. And I think, you know, trans fats have been removed for the most part, which is great, but you wanna make sure you're getting rid of those two things,

trans fats and I forget what's corn syrup. Just getting rid of that alone will make a huge difference. Or just even reading the ingredient list. If there's an ingredient on there that you don't have at home that you wouldn't use in your kitchen, like butylated hydroxy totoluene or maltodextrin or mono-endiclycerides, you probably shouldn't eat it.

I heard something once, if you can't kill it or grow it, you shouldn't eat it. And I always think about that when I'm eating food. Yeah, totally right, totally right. So a lot of our listeners are entrepreneurs. They have very busy schedules. Sometimes it can get really overwhelming trying to follow different nutrition advice.

So in the simplest terms, what should we be eating? Yeah, I've written so many books about this food. What should I eat? The Pegan diet, which is sort of a condensed version and with some kind of fun stuff in it. What we agree on is more than what we disagree on. You can get on the margins about vegan or paleo or keto or this or that, but the truth is,

and we all agree we shouldn't be eating ultra-processed food. We all agree we should be reducing starches, sugar, and refined carbohydrates in our diet. We shouldn't be eating things that aren't food, technically like maltodextrin or butylated hydroxy-toluene or red dye number three. We should be eating foods that are high in phytochemicals. We think of the food as medicine where it changes everything in our biology in real

time. We should be thinking about having good quality fats from nuts and seeds and avocados and wild fish, small fish. Even though for some people, it will tolerate animal fats very well, especially if it's regenerally raised, they have very different qualities of fats. There's a lot of really good things you can do that are available from the diet that you can get even anywhere. I mean, I've worked with people in the worst food deserts in America, and they've actually been able to make a huge impact and change

their diet if they actually do the right things. And they will. They'll actually have a huge shift in their diet by actually doing this. So I'm pretty thrilled by how simple it is, but when people understand how to do it, then it often needs to exist. Talk to us about exercise. I feel like there's a lot of mixed advice when it comes to exercise. What's your take on the right amount, too much exercise? Exercise is critical.

Your body needs to move. There's no doubt about it. We were designed to be moving organisms all the time. And that's how we evolved. Now, most of us don't do enough and that's unfortunate. And I think 8% get the optimal amount, 23% we get some moderate amount. But the key is to actually understand what's good for you. And it's different at different times of your life.

But I think you need at least 30 minutes of good cardio four or five times a week, three times a week is strength training, probably a week or a day or two of flexibility and training and stability training. That's kind of bare minimum. If you can do that, you're gonna maintain your health and be good for a long time.

You've said in the past that strength training is the best anti-aging medicine. What's so good about it? Because what you're doing is you're building muscle, you're building mitochondria, you're increasing muscle mass, and what really kills people is frailty. When you get older, you get frail,

you're not able to get up out of a chair, you're not able to do the thing you love to do, your mobility's decreased, your function's decreased. That's all totally preventable by strength training. And you have to work harder as you get older because the body, unfortunately, it doesn't work as well. So you have to do a little more effort to get the same benefit.

And I think that's something people have to do, but it's not optional. Like exercise is just not optional. Okay, last question for you. And then we're gonna close out this interview. So the average listener's age on my podcast is 35 years old and they're typically an entrepreneur. So let's say they gave you a 35 year old,

they're stressed, exhausted, running on coffee. If you had a year to transform their health and performance, what are the things that you would change? I would immediately have them get on a whole foods diet that I just talked about it and have them just follow the principles of the real food, low sugar starch, good fats, adequate protein for where you are in your life phase and varies depending on where you are, lots of phytochemicals, lots of fiber, and just start there.

If you're really having any health issues, I'd probably do my 10-day detox program, which is essentially a reset. It's just 10daydetox.com with a 10-day detox. What really is amazing about it is that people get a reset. It's just 10daydetox.com with a 10 day detox. And what really is amazing about it is that people get a reset. It's like putting your body back to its original factory settings, and you can see where food is impacting you. Oh, I didn't know that, oh, my rash was caused by food,

or I didn't know that my migraines were caused by what I was eating, or I didn't know that my joint pain was causing everything, or my sleep problem was caused by eating. So you get a really quick reset, and then you can start to add foods back in. So that would be number one, get your food straight. And that's timing, planning, organizing.

It's really important. The amount of time you spend on your business, the fact that you spend on your health, you'll get a lot of dividends from that. Getting regular exercise routine. Not that hard. Just maybe if you just want to walk 30 minutes, if you walk and phone calls, that's good, better than nothing. Uh, is going to have a walking treadmill. You can do more fun things. I like to bike. I like to do more

mountain biking and road biking and tennis and other things that are fun for me. I like to make exercise fun. Strength training, I've gotten into more and more and it's been profound in terms of effect on my body, even as I'm older. I think learning how to regulate your nervous system is important. Self-soothing is something we learn how to do. We get activated, reactive. But learning how to practice whether it's breath work or meditation or some practice where you're resetting your nervous system because we're all in parasympathetic deficit. We need to be relaxing more. And then I think build community because as you're building something and going through stuff, when getting isolated is the worst thing you can do for a human being. And so I think build community because as you're building something and going through stuff, when getting isolated is the worst thing you can do for a human being.

And so I think having that ability to work with your friends to build a fun community experience is really important. And that's something that's been really important to me, especially as I got older, is just invest in your friendships because when everything else goes, that's what will be left. Yeah, so that was great advice on an individual level. And a lot of the people tuning in are entrepreneurs and we help move society forward. And we have this big shift from traditional to functional medicine. We're trying to combat the food industries.

Can you talk to us about some of the opportunities that you see for entrepreneurs to capitalize on all these changes? The health and wellness market is a trillion dollar market. There's a lot of ways people are entering that, but you can figure out what you love and the intersection of what you love and what people need. Often businesses are started from people's own needs. I need to fix my own health. So as a physician, I got very sick when I was in my 30s.

I got chronic fatigue syndrome from heavy metals, and I was struggling a lot. And I had to figure it out. I had to actually figure it out. And that forced me to learn about what I learned about. It forced me to study the way I studied, to actually find this field of functional medicine, to use it in my cells, to heal and repair.

And so that's what I encourage people to do is figure out that intersection of what you love. That's just driven me, because it's not like a choice. I don't have a choice. It's not like I'm making widgets or something. It's fine to make widgets. We all need widgets. But I think the key is really to kind of figure out

how you can do this in a way that syncs with what you love, because otherwise you won't really do it. Great advice. OK, so I end my show with two questions. I ask all my guests. do this in a way that syncs with what you love because otherwise you won't really do it. Great advice. Okay, so I end my show with two questions. I ask all my guests. It could be totally different from what we talked about today. Just answer from your heart. So what is one actionable thing our young and profitors can do today to become more profitable tomorrow? What your success is really determined by the quality of how you feel. So if you're able to function on a high level and do the things you want to do and not be held back by illness or struggles, you're going to be able to

function at a much higher level and do whatever you want to do, whether it's just buzz off and go kind of get early retirement or whether it's you want to build a company or whatever you want to do, you know, you have the capacity to, to be highly functional when you feel better. And then so investing in your health is such an important thing from my perspective. You know, I see a lot of people who have great businesses and companies and they build these things, they're rich, they have all this stuff, and they're lonely, they're isolated, they're unhealthy, they're sick, they don't feel good. I mean, that's the last thing you want, right?

Totally. And your book, Young Forever, really is a blueprint for how to do that. What would you say your secret to profiting in life is? And this can go beyond business. The secret to profiting in life, again, is to focus on the things you love and to do what you're passionate about. Because if you try to force something in your life, the best things that happen are often serendipitous. They often come to you, their ideas, their people, their experiences. I feel like there's sort of an underlying current where we can kind of jump into it.

And if we're present, we're able to see actually what pulls us in. And when we do that, you become more profitable. I've never sought to make money in my life. I've never tried to make money. I've never said I'm going to do a business to make money. I'm going to do this to make money in my life. I've never tried to make money. I've never said I'm gonna do a business to make money. I'm gonna do this to make money. I'm doing what I'm doing because I feel like it's critical for myself and for the people who I care about and for the population at large.

It's like, I just can't help myself. So I think when you do that and you have a mission and you're driven, then it's not about the money. And Mark, where can everybody learn more about you and everything that you do? I know you're so, then it's not about the money. And Mark, where can everybody learn more about you and everything that you do? I know you're so easily found, but where do you wanna point people to?

Yeah, well, you can go to drheimann.com. If you wanna try the 10-day detox, you can go to Dr. Hyman. The entire time you'll find it there, but if you just go to 10daydetox.com, I'm on social media Dr. Mark Hyman and I have a podcast, the Dr. Hyman Show, the top 200 podcasts out there.

So it's doing well. Awesome, cool. Thank you so much for joining us on Young and Profiting Podcast. My pleasure. Well guys, that's a wrap on my conversation with Dr. Mark Hyman. What stood out for me today is that longevity

isn't just about adding years to your life. It's also about adding life to your years. And as corny as that may sound, if you want to be as strong and as vibrant at 60 as you are at 30, then it won't simply be because of genetic luck or new technologies, but rather because of your intentional living.

There's so many exciting developments in the health and longevity space from epigenetic reprogramming to AI informed personalized medicine, advances that will no doubt inform and accelerate our lifespans in the years ahead. But like Mark reminds us, we already have the tools and knowledge at our fingertips

that we need to optimize our health right now. And what it really comes down to is simply getting rid of the bad stuff and adding in the good stuff by improving our diet, exercising more, getting enough sleep and avoiding stress. You have it within your own power to age more slowly and even turn back the physiological clock. Aging is not a simple decline in many ways.

It's a choice, even a skill. Look at those people living in the blue zones like Sardinia aging slowly and gracefully because they've created a healthy environment in which their bodies can completely thrive. It's a lot easier said than done, but believe me, I know. Like Mark said, it's also never too late to get started at leading your best and hopefully longest life.

Thanks for listening to this episode of Young and Profiting Podcast. If this episode resonated with you, share it with somebody who wants to feel better, live longer, and thrive at any age. And if you enjoyed today's episode and found something valuable in it, we'd love it if you'd left us a five-star review on Apple, Spotify, Castbox, wherever you listen to the show. It means the world to us. I read your reviews every single day.

I love to get your feedback. It's one of the best ways to help us grow and reach more listeners. Prefer to watch your conversations? Then head over to YouTube and search Young and Profiting to catch the full episodes on there. You can also connect with me directly on Instagram at Yap with Hala or LinkedIn, just search for Hala Taha. And as always, I gotta shout out my incredible Yap team. I have such an amazing team at Yap Media. I couldn't do this without you guys. This is your host, Hala Taha,

aka the Podcast Princess, signing off. Music