Young and Profiting with Hala Taha - Dr. Mark Hyman: The Secret to Aging Backwards and Improving Your Health | Mental Health | YAPClassic

Episode Date: June 5, 2026

Dr. Mark Hyman’s health broke down in his thirties when chronic fatigue syndrome and heavy metal toxicity left him struggling to function. Conventional medicine, the very system he was trained in, had no real answers for him. Forced to search deeper, he discovered functional medicine, used it for self-healing, and later reversed his biological age by more than two decades. In this episode, Dr. Mark shares how entrepreneurs can take control of their health, slow aging, and use small daily habits to boost performance and live a longer, more fulfilling life.  In this episode, Hala and Dr. Mark will discuss:  (00:00) Introduction (01:45) The Science of Healthy Aging and Longevity (07:09) How Functional Medicine Optimizes Health (12:51) Biohacking vs. Functional Medicine Science (15:34) How to Reverse Biological Aging (20:12) The Role of Diet, Sleep, and Toxins in Aging (28:15) Living Longer With Purpose and Meaning (30:19) Navigating Modern Food Challenges (36:08) Why Your Social Circle Matters for Longevity (38:45) Diet and Exercise for Healthy Aging (41:39) Practical Wellness Strategies for Entrepreneurs  Dr. Mark Hyman is a practicing family physician, bestselling author, educator, and advocate in the field of functional medicine. He is the co-founder and Chief Medical Officer of Function Health, a personalized health platform that helps people understand and optimize their biomarkers. Dr. Mark is also the founder of the UltraWellness Center and the Cleveland Clinic Center for Functional Medicine. Through his work, he teaches people how to address the root causes of disease and build lasting wellness.  Sponsored By: Indeed - Get a $75 sponsored job credit to boost your job's visibility at Indeed.com/profiting Shopify - Start your $1/month trial at Shopify.com/profiting. Quo - Run your business communications the smart way. Try Quo for free, plus get 20% off your first 6 months when you go to quo.com/profiting Remitly - Transfer money internationally across 100+ currencies with no hidden fees. Download the Remitly app or visit remitly.com to get started. Use code BUSINESS to get a $100 bonus after you send $300 or more. New customers only. Prolon - Reset your body with Prolon’s five-day plant-based program. Go to ProlonLife.com/PROFITING for 15% off sitewide plus a $40 bonus gift when you subscribe to their 5-Day Program. Northwest Registered Agent - Get a complete business identity with Northwest. Visit northwestregisteredagent.com/YAPFree and start using free resources to build something amazing.  Resources Mentioned: Dr. Mark’s Website: drhyman.com  Dr. Mark’s Book, Young Forever: bit.ly/YoungForeverBook  Dr. Mark’s Podcast, The Dr. Hyman Show: bit.ly/DrHymanShow   Active Deals - youngandprofiting.com/deals  Key YAP Links Reviews - ratethispodcast.com/yap YouTube - youtube.com/c/YoungandProfiting Newsletter - youngandprofiting.co/newsletter  LinkedIn - linkedin.com/in/htaha/ Instagram - instagram.com/yapwithhala/ Social + Podcast Services: yapmedia.com Transcripts - youngandprofiting.com/episodes-new  Entrepreneurship, Entrepreneurship Podcast, Business, Business Podcast, Self Improvement, Self-Improvement, Personal Development, Starting a Business, Strategy, Investing, Sales, Selling, Psychology, Productivity, Entrepreneurs, AI, Artificial Intelligence, Technology, Marketing, Negotiation, Money, Finance, Side Hustle, Startup, Mental Health, Career, Leadership, Mindset, Health, Growth Mindset, Motivation, Manifestation, Brain Health, Life Balance, Positivity, Happiness Learn more about your ad choices. Visit megaphone.fm/adchoices

Hey, yeah, fam, we're about to launch something that might be my favorite thing we've ever done on the podcast, a brand new series called How We Profit. Now, I've been doing Young and Profiting Podcasts for eight years, and my listeners are successful. We are real entrepreneurs with real businesses, and a lot of you guys are crushing it behind the scenes. You may not be super famous, you may not be a billionaire yet, but you've got a business that you've learned how to scale. And we want to hear from you. One of the best ways to learn as an entrepreneur is from your peers. And I found it super helpful to be in these peer entrepreneurship groups and learn from other entrepreneurs who are at my level, but just in a different industry. So that's what I want to bring to this podcast. I want this to be our own peer group, but on the podcast. And so I'm going to be interviewing people who are making anywhere from $500,000 to $10 million a year. They're not super famous. They're not the typical billionaires that are on my show. These are real entrepreneurs who are crushing it behind the scenes. And we're going to uncover what they do to sell, how they get their customers, what their profit margin looks like, how they market, and so much more.

If this sounds like you and you want to be featured on Young and Profiting Podcast for our How We Profit Series, just head to younginprofiting.com slash apply and share your story. Let me know why you think you should be featured on the show. Again, that's young and profiting.com slash apply. And who knows, maybe you'll be our next guest on Young and Profiting Podcast. You want to live to be 120 years old. Why do you actually want to live so long? I love life. What is the definition of health? It's not the absence of disease. It's something else.

How do we unlock the keys to optimal biological performance? I've spent the 40 years studying the science of function of the body. Frailty is not a normal consequence of aging. It's a consequence of a phenomenon that happens as we get older if we don't do something about it. We have dysregulated sleep schedules. We have tremendous months of stress. We eat crappy food. We don't exercise enough. There's all these things that we're doing to impede our ability to actually live a vibrant long health. your life. What did you do to reverse your age 20 years? I have been eating. Let's say you gave you a 35-year-old, they're stressed, exhausted, running on coffee. If you had a year to transform their health and performance, what are the things that you would change? I would immediately have them get. Yeah, Pam, what if aging wasn't something that just happened to you, but something you could actually control? What if the fatigue,

the brain fog, the chronic conditions we've been told are just part of getting. older, are actually preventable. That's exactly what today's guest is here to talk about. Dr. Mark Hyman is a renowned functional medicine physician, best-selling author, and one of the leading voices in the science of longevity. His mission is simple, help people not just live longer, but better. In this conversation, Mark is going to share some science-backed insights to help you improve your health, extend your lifespan, and defy aging.

There's some serious gems in this one, so tune in and take notes. I'm so excited for this conversation, and there's so much to talk about, but I just want to jump in and get started. So I was reading your book. I was researching you, and I found out that you want to live to be 120 years old. Oh, if I can do everything I'd love to do, yes. If I can, no. Yeah. I'm still riding my bike at 119. I'll keep going. That would be amazing. I also interviewed Dave Asprey a few times, and he tells me he wants to live to be 180 years old. So there's this trend of biohackers like you guys that want to live to be 120, 180 years old.

I would just say I'm not a biohacker. I'm a functional medicine physician. And so I use deep science and it's not, I mean, some of the tools are similar. But functional medicine is really the ultimate biohacker. Yes, yes. And we're going to talk all about functional medicine. And I'm going to try to help my listeners understand what that is if they're not familiar. But you guys are on a quest to live as long as you can, right?

So that's the two things that you guys have in common. Maybe it's not biohacking. But when I think about that, I think about frail, old, bedridden. I don't really want to live to be 120 years old, at least by today's standards. So I want to understand when you imagine yourself at 120 years old, what do you actually imagine yourself being capable to do? What does 120-year-old and thriving look like? I mean, it means being able to do whatever you'd love to do.

sitting in rocking Jeremy a book, it's that. If it's hiking up the mountain, it's that. If it's making love with your partner, then it's that. For me, it's really being able to get up in the morning and do what you love to do and not be encumbered by some of the conditions that are mostly preventable that we seem to think of normal of parts of aging. They're not really. And what's happening on the science is quite exciting. We were seeing a lot of research, for example, as a Washington Post article recently about the Aminox Factor's, which is basically a scientific discovery that won the Nobel Prize, it allows you to reprogram. your genes back to a younger you. It's called epigenetic reprogramming, and it's being researched by

the Altos Lab, and also by Sam Alman's Lab. So there's a lot of really amazing research going on in this right now in longevity space. That's going to be an unlock. For most of us, I think we can expect to get to our 90s or be 100, you know, bigger and good health if we know what to do to take care of bodies. And I saw this all over the place. I mean, I was in Sardinia and I was in Icaria. And I just saw people who are like really old and really thriving. And, you know, this woman was like 87 years old and she was like running up and down the mouth side of this mountain. I couldn't keep up with her. She was, you know, attending to her giant gardens and farm and animals and trees. It's quite amazing to see. So I think if we understand the things that impede our health, we can remove those and we

understand the things that enhance our health. We can add those. And it's really not that hard. It's just knowing what to do. Yeah. And I hope we can unpack some of that in the, this interview today. So I was listening to your audiobook, Young Forever. It was really entertaining. And you were talking about how you went to Sardinia and went to the Blue Zones. But talk to us about what actually sparked your interest in longevity. Well, I've always been interested in the science of optimization in terms of how we function. I mean, whether it's the word functional medicine or the company I co-founded function health, the core value is how do we unlock. how to function at your best

and how to unlock the keys to optimal biological performance. And it's really something that we're not only discovering. No one's really asked a question in medicine before. What is the definition of health? It's not the absence of disease. It's something else. And if you go to your doctor, you feel good.

I want to feel better. I want to optimize it. They don't want to do. If you have symptoms, great. If you have a disease, they'll give you a drug. But do they understand the science of creating health? Now, that's what I've spent my life studying after medical school, the science of creating health. And it's something we now know how to do.

And that's what's so exciting. We know the basic biological systems that go right. And in the field of longevity, the science is really getting exciting because we're talking about these concepts called the hallmarks of aging. The hallmarks of aging are these fundamental biological things that go wrong or break down as we get older that are underlying all disease. It's like the roots or the trunk. And all the branches and the leaves are all the things. the diseases and all the specialties. So it's heart disease or cancer, diabetes, or Alzheimer's, or whatever it is, autism, depression, they share common roots. And there are only really a few

things that impede health. You have to identify what those are. There are toxins. There's allergens. There's allergens. There's microbes and change your microbiome, which is physical or psychological stress, and poor diet, which is most of us to eat. And then there's a few things that our bodies need to thrive. So you need to get rid of the bad stuff and put it in the good stuff. And then there's ways of even sort of accelerating optimization things, for example, like how do you optimize your mitochondria, how do you optimize your microbiome, how do you optimize your neurotransmitter function, how do you optimize your immune system? These are things that we now know how to do. If you say to your doctor, I want to optimize my mitochondria and figure out how to optimize my

immune system, and they're not going to know what to do. How do I optimize by micro-melt, take a probiotic, you know, eat fiber. They're not going to really understand because it's not what they do. And I've spent the 40-year studying the function of the body. And that's really what we kind of have come to in terms of understanding how to create these shifts in our biology that create abundant and vibrant health and that don't provide a breeding ground for disease. So with traditional medicine, really they're focused on like a specialty, right? They don't treat the whole body holistically. So can you give us an example of like, okay, I go to the doctor and I'm like, hey. I'll give me an example. I'll just tell you an actual patient I had. I'm not going to use her name, but she was a business coach

by 50 years old. She was overweight. She had prediabetes. She had depression. She had migraine. She had brief flux, she had irritable bowel, bloating. She had a terrible story. He had arthritis, which is a horrible condition where you get psoriasis and all over your hands, the skin and body, and you also get arthritis, which is debilitating. So she was on a drug for that that costs $50,000. She was seen by the best docs, one of the best healthcare centers in the world, and she was getting the best GI treatment for a reflux,

the best treatment for irritable bowel, the breast treatment for depression, quote, the best meaning the best traditional view, the best treatment for migraines, the best treatment for her pre-diabetes, the vestibum of her, sorry, arthritis, and she was seeing a doctor for every inch of her, and no one said, what is linking all these problems together? For her, it was inflammation. She had tremendous amounts of inflammation that were driving all these conditions. Now, we know a depression is inflammation, right? We know that if your guts upset, it's inflammation.

We know that, obviously, if you have inflamed skin and arthritis, that's inflammation. So we know that diabetes is inflammation or pre-diabetes or obesity is inflammation. So I said to myself, well, what did the root cause for her? you know, she was having so many gut issues that I believe those are the cause. She had severe bloating. She had all these history of taking antibiotics, the steroids for various things like for her autoimmune condition. And I said, why don't we just do something really simple? Rather than taking all these drugs, you can continue to take them. But in the meantime, let's just try you on a Whole Foods, low sugar, low starch diet, which removes the common inflammatory triggers.

And for my practice, for people have autoimmune disease, getting rid of grains and beans, dairy, gluten, which is part of the grains, bigger, processed food, alcohol, really makes a difference. So I said, put her on that diet. I said, let's kind of reset your gut. I gave her an antibiotic and an antifungal to reset her gut. And then I gave her probiotics and things to rebuild her gut. And I gave her, I think, vitamin D and some fish oil, not a lot of stuff. And six weeks later, she comes back, says, Dr. Hyman, I got off all my drugs.

I'm going to wait, I didn't tell you to do that. She said, no, I just was feeling so good. I just stopped everything. And she had no more seredic arthritis, her skin care, clear, up. She had no more migraine. She had no more depression. She lost 20 pounds. Her pre-diabetes was gone. Her her reflux was gone. Her inner bowel was gone. And so I just treated the root cause, not the symptoms. And this is this inflammation is a common trigger for most chronic diseases. And for her, it was, you know, for me after seeing this for 30, 40 years of patients like this, I can see it,

you know, when they walk in, I know what was going on. And it's not that hard to treat. But she was getting all these symptoms suppression treatments that weren't really working. They were marginally working. They were keeping her functioning sort of, but they didn't really deal with the problem. So functional medicine is about really understanding the body as a network, as a system, as a system of systems that you have to keep optimized in order to live well. And they map almost entirely perfectly across the hallmarks of aging, the scientists ever discovering. So when your mitochondria don't work, when your detox system doesn't work, when you have, you know, immune imbalances, or hormone imbalances, or neurotransminder balances, or your guts off, these are things that we

actually know how to treat your mitochondria aren't working. These are things we know how to treat with functional medicine. And talk to us about how your company function services these types of problems. What we've done with function is really create the first health platform that allows people to fully access their own data. Now, people are wearing orr rings, they're wearing Apple Watches, they're wearing glucose monitors. That's all great. That's just a few data points. But what if you could unlock all of your biology? What if you could note all your biomarkers and your metabolome and your microbiome and your microbiome and your genome, imaging, your wearables, and your medical history, and your EMR, your medical records, all gets into a platform that is personalized to you and allows you

to identify where the imbalances are, where the dysfunctions are, and gets you deep insights and content based on machine learning AI to help you actually optimize your health for you. Because no two people are alike, and everybody's different, and if we try to treat to the mean, we often miss the mark. And this is what medicine does. It treats to the mean. There's no person, right? Everybody's different. And you know, the studies work by something called randomized control, no blind trials, which means, control means you basically have two populations that are as identical to each other as possible. So you want to be a 70-kilogram white male from Kansas, and you get 100 of those people, and you put 51 group and a 15 other group,

and you give them a drug, and you see what happens at the other side. That's how bed is and it operates. That 70-kilogram white male is not like 90% of us out there. Not you, it's not me. And so how do we move towards where medicine is going, which is personalization? We call precision medicine, personalized medicine. What are we going to call it? It's where we're going. And so function health is the first platform that is able to actually do this for you in an amazing way that helps people revolutionize our health.

And we just started, honestly, this is a startup. And we didn't realize how much success we were going to have. And so, you know, we have almost 150,000 members. We have, you know, millions, tens of millions of data points on people. We're seeing all kinds of trends. in the data. We see that people actually, you know, when they get their first test, and now we've been going two years, we can see that when they follow up and do the follow-up testing, that their biomarkers get better. Their bloodshare gets better. Their cholesterol gets better. Their inflammation gets

better. Their vitamin D gets better. Whatever, whatever is off. And we give them a deep dive into what's going on with their biology, not just from a traditional perspective, a traditional sort of Western medical perspective, but also this emerging field of systems network medicine, which is what functional medicine has been doing, but now the rest in science is catching up, which is very, very exciting to me. Yap, gang, do you want to look and feel your best this summer? And I don't just mean looking good on the outside. I mean feeling amazing from the inside all the way down to yourselves.

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when I tried to compare what you were doing with biohacking, but when I hear you talking about it and you're talking about personalization and figuring out. not like, you know, your biological age. To me, that's, you know, I've been doing this podcast for six years and had a lot of people on the show and it sounds a lot like biohacking. So, what's the difference?

Well, I think biohacking tends to be around things like, you know, hot and cold plunges, hyperverick chambers, red light therapy, all these devices and tools and things, optimize your health, which are fine. They work and they're mediated by biological processes, and I use those. However, if someone comes in like that woman that I just described to you, no biohacker in the world is going to fix her because they don't understand the science around ultrasound. Now, if they're a trained practitioner, fine. They'll figure it out, or hopefully they'll figure it out. But when you just use these modalities without trying to understand

what the underlying root causes, it's another symptomatic treatment. You might feel better for a little bit. You go on Osana, you go on a cold plan, you feel good. But then what? You know, you still have your arthritis, you still have your autoimmune disease, you still have your migraine, you still have whatever you got. And no one's telling you how to figure out the root of that. So I'm not, I'm not opposed to it. And Dave's a good friend. And I love Dave Asprey. And we, we hang out and talk all the time and I learn from him. And there's other, there's all kinds of great tools that I personally use and have. I'm just saying that the functional medicine is sort of the OG biohacking in a sense, because it's really about understanding a much deeper level, what's going

on biologically, biochemically, genetically, you know, with your microbiome and ways that I think, you know, most people just, it's a lot to take in. You know, and the problem is, you know, there's 37 billion billion chemical reactions to your body every second. Nobody can understand all that. And you have tens of thousands of metabolites in your blood and chemicals. You know, we do 19 on a regular panel. With functional health, we do $4.99, which is, you know, $15,000 for the test for less than $500, and you get over 110 biomarkers, and you can add on other things as well to go deeper dives into whether you're exposed to chemicals, whether you're at Alzheimer's risk, whether you're having immune issues.

I mean, so, well, you have Lyme disease. We provide you a really deep, robust platform where you get to be driving the bus. You don't have to go to a doctor. You don't have to ask for permission. You don't have to beg for the requisition. You have to go to the, you know, trying to find a lab that we order. You have your insurance to pay for an offer.

I mean, I have insurance. I go to the lab and my doctor ordered some stuff that I wanted to do. And it was outside of function. And she's like, well, it'll pay for this test, but not this test, and this test, on this test. You know, I'd be charged for that. You'll be charged. I'm like, oh, you know, it's like,

But that's what function solves all of that, and you're this beautiful, integrated dashboard where you have your data forever and you track it over time. You get an app, which helps give you direct feedback, and it's a very, very integrated experience in your life. Yeah. And I feel like it's really needed because, to your point, the rest of the medical world is kind of stuck in this traditional process that really isn't working. And the other thing that's not working is actually treating aging's symptoms and not the root

cause. And one of the other big principles that you talk about is treating aging, like, you're an actual disease. So why is that important? Well, I think, you know, we've come to sort of accept that as you get older, you have cancer, you get heart disease, you get diabetes, you lose muscle, your brain function declines, you lose your ability to do things. These are not normal consequence of aging. Frailty is not a normal consequence of aging. It's a consequence of phenomenon that happens as we get older if we don't do something about it. And, you know, all of us have seen those, you know, nine-year-old ladies doing, like, gymnastics.

and the 100-year-old people running the 100-yard dash. It's kind of crazy stuff like that, right? And so what is it about those people? Well, they have understood by accident or by studying that there are certain behaviors that foster optimal health. It's eating whole foods unprocessed diet. It's low sugar and low starch and full of phytochemicals and fiber and got it with amounts of protein, especially more protein than the animal protein as you get older because

it's harder to assimilate and build. you need to make sure you exercise and do strength training and you need flexibility, you need cardiovascular training and stability training. They understand you need good sleep. They understand they have managed their stress and their own emotional regulation. And they also have deep social connections and relationships that foster a sense of belonging, which are all are ingredients for optimal health. And when you look at people like in the blue zones, that's basically what they have.

It's not that they were vegan or not vegan. It was that they had these other factors and that they were profoundly impacted just by default, by these situations that they found themselves born into, which we totally in the West don't have. Like we're the opposite. We have dysregulated sleep schedules. We have tremendous months of stress. We eat crappy food. You know, we don't exercise enough. We, you know, like, we got my R-R-R-ring told me I didn't exercise enough yesterday. I was a busy day. So, you know, there's, there's all these things that we're doing to impede our ability to actually live a vibrant, long, healthy life. Well, you seem to be doing a good job because your biological age is 43,

but you're in your 60s. Is that right? Yeah, well, I got my biological age done when I was 62 and I was 43. Then I implemented more of the things that I learned and some, you know, some other strategies. And I got two years older at 64 and I redid my biological age. It was 39. So I went even though I got two years older chronologically, I got four years younger biologically. So, So that's the power we have. And this is what we call epigenetic reprogramming. Now, I mentioned earlier the Amanaka factors and so forth. These are sort of behind the sky things that have to be tested in humans and make sure

they're safe and effective. But right now, I mean, even with what we know, by optimizing and tweaking, you can actually still reverse your epigenetic biological age at any point in your life. And it can go backwards or forwards. You know, like if you kind of go on a bender or whatever, you don't sleep and you party and you eat crap food, you'll get older biologically. And then you can change that and reprogram and go back. I wouldn't recommend that.

Give us concrete things. Like, what did you do to reverse your age 20 years? Well, I've been doing this my whole life. So it wasn't like I was 64 and then I, biologically, and then in five years I reversed it to 40s. So, okay, I have been eating whole foods my whole life. I've been not eating processed foods. I don't remember last time I had a Zoda.

I mean, I probably was a kid. I exercised my entire life for the last 50 years. I have, you know, make sure I prioritize community, connection, sleep, and men's stress. And all those things play a role. And then I've done things to optimize my microbiome, my mitochondria, my immune system. And those are all really helped. So all those things kind of just kind of nudge you back into healthier state. And there's some supplements and things that I've taken that I think made a difference.

I've taken uralithinae. I take amino acids that should help be assimilated. I also take something that's called NMN, which is a precursor of NAD that helps also revitalize yourselves. So I do a number of different things that I think are important from a supplement perspective. But I think most of it's, you know, that's like the 10%. It's like the rest of it is the 80 to 90%. And that's what if we were to, you know, use function, the platform, it would help.

help us figure out like, okay, what's our biological age? And these are the things you need to do relate to functional medicine and to help. That's what it does. Yeah, we do a calculation based on your biomarkers of what your biological age is based on scientific data that shows, you know, certain blood biomarkers correlate with your epigenetic biological age. And you can see it go backwards or forwards. Now, if you do a different test, you're going to get different numbers, right?

Some tests will, you know, like some tests will be like five years younger or 10 years younger. And so you may not, you may not kind of be able to compare. apples to apples by switching tests. But if you stay with the same test, consistently, you'll see the changes. Yeah. Okay. So I want to get really nerdy because I'm sure people have been listening and they're like, I have no idea what epigenetics is. And so there's two terms I want you to break down. Epigenomes and exosome, right? I know that. So one is about how our genes are expressed. One is our environmental exposure. So break those. Yeah. So basically the concept that I think is really important called the exosome. We all have been taught that our genes control who we are. They're our destiny.

whatever we got, we got, we can't change it. You know, our parents got diabetes, our parents got cancer, our parents got, whatever, heart disease. It's just kind of in our future. Your genes are not your destiny. They may provide you with a roadmap of what your predispositions are, but not your destiny. So what controls your destiny? It's something called the exposure. That is a sum total of everything that you're exposed to throughout your life that washes over your biology,

including your genes, and reprograms them based on what you're doing. If you're eating like me, if you had a whole food diet, if you exercise, you do all these things for 50 years, you're going to be biologically younger. Your epigenetics are going to track as if you're younger. And I'll talk about what epigenetics are. So the exposome is what you eat. It's your exercise, your nutrient levels, it's stress management, it's community, it's sleep. It's all the things we've just talked about. Light, air, water, all those things.

I went on in bright sunlight this morning for 20 minutes. All those things matter. That influences how your biology is regulated. biological organisms and we're controlled in the same way by our external factors. So the exposome is literally everything from toxins to your gut microbiome, to your diet, to sleep, everything that your body is exposed to. That's why we call it the exposome. Your epigenome is how the exosome regulates your biology. Now, what is the epigenome? Epi means a bone. So you've got your genes, you've got about 20,000 genes. Your epigenome,

and then the thing about like the keyboards on our... on a piano, right? You got 88 keys, they ain't changing. You know, I got 20,000 genes, they ain't changing unless I do gene editing or splicing or some other weird thing that's coming around the corner. They're not changing. What can change is how those genes are expressed, how they're turned on or off, whether they're up, regulated or downregulated, whether they drive inflammation or stop inflammation, whether they're accelerating aging or slow aging. And they are basically the control mechanisms to turn on or off teams. So like think of them like switches. or knobs, and you can down them up or down based on what you're doing. And that's how almost all

of the impacts of a lot of the long practices we talked about have their effect. That's how the exposure regulates your health and lungs. Your biology and your risk of disease is through your epigenome then translates into the expression of genes and proteins and biological functions, and you want to have a healthy epigenome. And, you know, there was a great example, for example, a Randy Journal who discovered this kind of phenomenon. was these mice that are bred to be obese. So you're yellow, they're fat. Specifically yellow fat mice.

He gave a series of the females who are pregnant. Certain nutrients called methylating nutrients that regulate the epigenome. So it's a little complicated, but there's something called methylation, which is a chemical process that regulates your genes. It involves B6, folate, and B12. So vitamins and minerals are extremely important. They run everything in your body. Every biochemical reaction needs a vitamin or mineral.

And if you don't have them or they, they're insufficient, you're going to have gummed-up biochemistry. And gummed-up biochemistry translates into disease. So he basically gave these pregnant mice some B-bitamins and a few other amino acids and things to help this support this process. The offspring were perfect. They were thin, they were healthy, they were gray. They were not yellow fat mice. Even though genetically they were bred to be yellow-fat mice. And this was a massive discovery, and I think this is what really has led to our understanding of this whole process of how we can modify our epigenome and the outcomes. So when your mother's eating when she's pregnant with you, you know, the stresses you experience

you know, in utero that your mother might have experienced or all your early childhood experiences, all those imprint on your epigenome and can affect you. Toxins you're exposed to. So this is why we have to pay attention to how we live, because if we want to feel good and do good and engage in life and do the work we want to do and be successful in our work and have great relationships and enjoy life and be happy. If you feel like crap, it's not that much fun. Yeah. So true. And so from what I read, like 90% of disease and aging risk has to do with our environment, our exosome, right? And so the earlier that we start the better is what you were just saying, right? You can even start from in the womb if our mothers are smart enough. That's great. Yeah. Yeah. You know, like, you know, I've seen

And women wanting to be pregnant, I measure their toxin load. I'm like, whoa, we got to do something about this. We've got to reduce your exposures of toxins. They've got to get these heavy metals down because you want a healthy baby. And so we rarely proactively do preconception work. I had a whole podcast about that on the doctor's pharmacy. And now it's called The Dr. Hyman Show. And we dove deep into what you need to know preparing for a baby, what happens when you're

pregnant. How do you take care of yourself? What are the things that are mad or scientifically to optimize the chance of having a healthy baby. On the flip side, is there any time that's like too late to get started on this? Oh, God, no. I mean, what's really amazing, and none of the animal studies, they give them rapamycin, which is something that is a drug discovered in Rapamy that inhibits this pathway called one of the longevity switches. I call them longevity switches that control so much. So mTOR is one of these. And mTOR essentially is a pathway that is going to help you build muscle, but also when it's

activated and when it's inactivated or inhibited in some way, it's going to allow the cells to replenish repair through this process called autophagy, which basically means you're eating your old cells and you're reusing the parts. It's recycling. So it's cleaning up the mess that we make all time in our bodies. Where does that garbage go, right? Somebody has to fix it. So Rapamycin inhibits that and accelerates the autophagy process and then give it in the right ways. It extends life and extends health in animal models consistently and reliably. And so there are interesting ways that we can sort of activate these longevity switches and pathways. And I talk about that a lot of my book, Young Forever, and how do we understand how these work, what we can do? And it's not a complicated.

There's a few simple practices, sometimes a few supplements that can really help modulate some of these pathways to activate the longevity switches. Okay, so one more really nerdy question, and that's about mitochondria. So you say the difference between a three-year-old and a 90-year-old is a number and the state of their mitochondrial. So help us understand what mitochondrial dysfunction has to do with aging. Yeah. Great, great question. So this is one of the hallmarks of aging is mitochondrial's function. It's key to so many diseases. Your mitochondria, I think of them is like the powerhouse of your cell, little energy factories, they take food and oxygen, turn into energy that your body uses. And we use, you know, gasoline or carb and it combusts and, you know, create the energy.

We run on something called ATP. It's just a molecule produced from food and oxygen. And the waste products are carbon dioxide, which we breathe out and water, which we pee out, and some free radicals, which we have antioxidant mechanisms to control. And what happens is they're your energy, right? So if you have poor functioning mitochondria, you're going to have low energy. You're going to be weaker, you're going to lower muscle mass. So the key to longevity is keeping your mitochondria healthy and keeping them strong and actually having better, more mitochondria. And so the way to do that is by exercise, so resistance training builds muscle and mitochondria, a sprint training, or kit training, does that as well. Exercise with oxidant therapy, hypoxia training does that. A lot of ways to do it.

There are supplements like urelofen A, which is caused mitophaginae, mitochondrial, support supplements sometimes that you need. So there are a lot of ways to optimize your mitochondria, but they're injured by too much food, too much sugar and starch, too many environmental toxins, all those things with microbiome that are bad. All those things can damage your mitochondria. So learning about your mitochondria, how to take care of them is really important. And again, it's one of the things we kind of can look at as we start to test things and see what's going on our bodies. So interesting. Yeah, bam, in business, communication is part of the client experience. Think about it. When you need to buy something or book a service urgently, and the first business doesn't answer, do you sit around

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industry's best business partner Shopify and start hearing. Sign up for your $1 per month trial today at Shopify.com slash profiting. Go to Shopify. dot com slash profiting. That's Shopify.com slash profiting. Okay. I want to talk about your drive of wanting to live so long because one of the

factors that you mentioned is like having a purpose and feeling like, you know, you've got a way to contribute to the world. So why do you actually want to live so long? Well, I love life. And as long as I can enjoy life and be with my friends and do the things I love and ride my bike and

hike and enjoy what I'm doing and have meaning and purpose and contribute to the world and add value. I'm 65. I kind of figured a few things out by now and, you know, wisdom always doesn't come with age, but I've had a bunch of hard knocks and that's really taught me a lot. And so I kind of feel happy and content and satisfied and I want to keep going. So I mean, I don't really care if I get to 120 or 100 or 99 or 95 or 90. I just want to feel good and do good. It makes a lot of sense. And I'm really excited for this generation of 60-year-olds because I just feel like in the past, you know, when you're in your 60s, it's all about like retirement.

And I feel like a lot of people right now are actually like taking on second careers and realizing that they really have a lot more time to live. And people are taking advantage of that. So like what are your thoughts in terms of people around your age who like want to take on a new career? Yeah. Yeah. Tell me. I mean, you know, I'm thinking.

65, and two years ago, I co-founded a company that's a big startup company right now. So, I mean, who does startups in their 60s? Most people are looking at golf courses and not startups. And I mean, I want to contribute to the world. I want to do things. I get excited. We're building. We're creating.

We're dreaming. We're imagining a different future for healthcare and medicine. We're adding value of people's lives. I mean, it's something to get up for every morning and be excited about and take all the things that I know that are almost impossible for any single doctor to synthesize and to sort through and make sense of and provide each individual with a personalized approach to their health that's going to optimize how they feel. And that's really the key here is to end needless suffering. And for me, that's my purpose and that's my mission. And plus having fun and enjoying my life

and my wife and everybody around me. Yeah, I love that. So it's hard for me to imagine at the same time, Like, I see people living older, but it's also hard for me to imagine, especially in the West, because I feel like things are more unhealthy than ever. The food in the grocery store is terrible. It's like everything comes in a cardboard box. Our water supply is really scary, and it feels like there's no good water. It's either like you're getting plastic or you're drinking from, you know, a dirty faucet, right? And so for me, it just feels almost impossible to kind of navigate food, which you say is medicine. So talk to us about how we should try to navigate our diets and also maybe like what changes need to happen in America for us to actually live healthier lives and longer lives.

This is something I've been working on for a long time. And I wrote a book called Food Fix, which lays out from field to four, what's wrong with our food system. And, you know, if there's one thing that's killing us, aside from environmental toxins and stress in our same schedule, it's probably 80% food. And it's something that we can control and do something. about. And unless we actually take it seriously and fix our food system, we're kind of in a mess. And so right now there's a resurgence of interest in health around the country. There's the making America healthy again movement. And so there's an energy happening. And in Washington, working on policies to bring those dangers to the average Americans. For example, in West Virginia,

they got rid of red dives and other dives in California. They do the same thing. These are great steps to start to push the food system to produce healthier food for all of us. I think that's really hot right now is GLPs, right? I have mixed feelings about them. I feel like it's good for personal. I'm not a doctor, right? But I think it's good if you have a real problem. But I see normal people who might just need to lose 10, 20 pounds take GLPs.

So what are your thoughts around that? I think for most people, and I literally just got a text from somebody this morning, saying my cousin read your book, they lost 100 pounds. My person who's working with me in Washington around food policy. She lost 112 pounds in the last year's working with me. And without taking me to these trucks. Now, some people are really stuck. And if you're stuck and you need help and you have not really addressed the underlying

reasons why you eat at, sometimes it's not what you're eating. It's what's eating you. You've got to figure that out. It's really important to do that. And I think what people do that, they don't necessarily have to take these drugs, which are helpful. They can be extremely helpful. but they also come with side effects.

Muscle loss, weight gain if you stop, they can have other issues, like pancreatic issues and pancreatitis, and they can cause bowel destruction if you've taken it for a long time. So they can be a good tool, but they're just a tool. They're not a panacea,

and I think they've helped a lot of people. I'm not against them. I think they're kind of used in ways that sometimes don't make sense to me. Why give a six-year-old an Ozzypick shot for the rest of his life? You know, it's not his fault. He's overweight.

It's the environment he's in. And I think, that can actually get really fixed. So I think it's important for people to understand that they have power. And the food industry is basically hijacked our brain chemistry, our metabolism, our desires for different foods. And these are things that can actually be changed. You can literally change your brain chemistry and have an incredibly powerful shift in your

cravings and your desire for foods. You know, for example, people go on keto, they don't really need OZEPA because naturally the way they're eating will shut off that craving. And the food addiction is a real thing about 14% of adults and kids are addicted to food, biologically addicted. This is really based on good evidence from Yale food addiction scale and deep science around the world. We looked at this. This is just horribly sad and horribly sort of unfortunate because we really, don't need to do that. We really, we can't, we can't fix our food supply. We can fix this problem.

And it has to be done in grassroots level. It has to be on a state level. It has to be on a federal level. It's going to take time. But we're working with the FDA, work with the USDA, with HHS and the administration as best we can to try to push changes through my nonprofit. I've also heard that there's food companies already trying to figure out how to like circumvent GLP so that people still crave their food, right? So, so yeah, I also read out. That's like, Yeah, that's even crazy when you think of it. Like, wow, they're really just going to go there. They're literally going to just kind of circumvent O-Zempic by making even more addictive.

Yeah, that's the state of the world that we're in. So we've got to take control. So let's talk about our ancestors because when I was listening to your book, I was surprised because we're always thinking about how we live so long now. And when you think about the past, you might think people died at like 30, 40. but there's actually cases in history where people have lived to be a very old age. So talk to us

about how our ancestors ate and maybe some examples of people who lived really long back in the day. I think, you know, when you're looking, for example, at the Native Americans, one of the longest populations in the world until the turn of the 1900s was the Plains Indians.

They had almost their diet from bison. And then they had berries and they had probably wild stuff they gathered. But predominantly their die was meat. And they lived to be like well over 100 and highly functional and active. And, you know, these populations around the world where you see people like I was in Turkey.

And they know, this is not a technical blue zone. But man, they were a lot of really old people who are doing great, you know, who were in their 80s, 90s still working, still thriving, still make part of the community. And I think it's when you stop, you stop. Like I think retirement is the worst idea ever invented. I don't really get it. But people don't retire. They just shift and change what they're doing.

And I think in these communities, and when you see these people living to be very old, it's because they found meaning, purpose. They've learned how to not sort of internalize the stresses of life. They've learned how to modulate their own diet and lifestyle to optimize their health. And they just kind of figure it out. Let's stick on community a bit because you say it's also a factor in longevity. You say you're only as healthy as your five close. assist friends. Tell us about it. Well, think about it. If all your friends are, you know,

going to McDonald and drinking beer and, you know, 20, 200, 2-0-2-0-0-0-0-0-0-0-0-0-0-0-0-0-0-0-2-a-a-tall-a-tie, you know, that's kind of what you're going to be probably like. And if you are friends who are healthy and go to go to yoga and drink green juices and exercise and eat whole foods and, you know, get together and share these things, you're more likely going to be healthy. And it's just so clear. Christacus from Harvard did a lot of work on this. He wrote a book called Connected. But he published research in the New England Journal of Medicine showing that, for example, from the Framingham data, which is a large study, one of the largest studies in the world, in Framingham, Massachusetts tracking their population. He found that those people who actually, when they looked at the patterns around obesity, that you were about, you know,

40% likely to be overweight if your parents or siblings were overweight. But you were 171% more likely to be overweight if your friends are overweight. Wow. Yeah. So your social connections matter and your relationships matter. You know, like, I mean, if you're somebody who just stays up all night playing video games and you're living in America, because your friends are playing video games in Australia, I mean, you're asleep, wake cycle, your circuit your rhythm, everything's

going to be off. So the people in the communities that you have to surround yourself with, make sure that people who are leaning in towards wellness and health as opposed to, you know, not not math. That's so interesting. Now, I don't want everybody tuning in to, like, become, like, fatphobic, you know? Like, we've got, but at the same time, you've got to pay attention to your, it's the same thing. If people are, like, doing drugs around you, you're more likely to do drugs. So food can also be as bad as a drug.

We've got to think of it that way. So if there was one thing that you could remove from the grocery stores, what? what would it be? It would be high fructose corn syrup. My dad, you'd kind of cut out most of the grocery store. Yeah, that's probably that I would do. And then what is your, oh, go ahead. No, that's what I would.

And I think, you know, trans fats have been removed for most part, which is great. But it's, you want to make sure you're getting rid of those two things. trans fats and I forget out of scorn syrup. Just getting rid of that alone will make a huge difference. Or just even reading the ingredient list. If there's an ingredient on the air that you don't have at home that you wouldn't use in your kitchen, like betelated hydroxytoluine or maltodextrin or mono and diglomerides, you probably shouldn't eat it. I heard something once, if you can't kill it or grow it, you shouldn't eat it.

And I always think about that when I'm eating food. Yeah. Yeah. Totally right. So a lot of our listeners are entrepreneurs. They have very busy schedules. Sometimes you can get really overwhelming trying to follow different nutrition advice. So in the simplest terms, what should we be eating?

I've written so many books about this food what they should I eat, the Pagan diet, which is sort of a condensed version and with some kind of fun stuff in it. And it's really, you know, what we agree on is more than what we disagree. You know, you can get on the margins about vegan or paleo or keto or this or that. But the truth is, we all agree we shouldn't be eating processed, ultra-processed, but we all agree we should be reducing starch and sugar and refined carbohydrates in their diet. We shouldn't be eating things that aren't food technically, like, you know, multodextrin

or, you know, butyl-label hydroxytotilene or red dye number three. You know, we should be eating foods that are high in phytochemicals that we think of the food as medicine where it changed everything in our biology in real time. We should be thinking about having good quality fats from nuts and seeds and I'm And then wild fish, small fish. And even though, for several, we'll tolerate animal fats very well, especially if it's regeneratively raised, they have very different qualities of fats. So there's a lot of really good things you can do that are available from the diet that

you can get even anywhere. I mean, I've worked with people in the worst food deserts in America. And they've actually been able to make a huge impact and change their diet if they actually do the right things. And they will. They'll actually have a huge shift in their, in the food. their diet by actually doing this. So I'm very, I'm pretty thrilled by how simple it is, but when people understand how to do it, then it then I've any stages. Okay, so talk to us about exercise.

I feel like there's a lot of mixed advice when it comes to exercise. What's your take on the right amount too much exercise? Yeah, I think, I think, you know, exercise is critical. Your body needs to move. There's no doubt about it. We're designed to be moving organisms all the time. And that's kind of how we evolve. Now, most of us don't do enough, and that's unfortunate. And I think we don't, I think 8% get the optimal amount, 23% get some modern amount. But the key is to actually understand what's good for you.

And it's different at different times your life. But I think you need at least 30 minutes of good cardio, four or five times a week, three times a week, a strength training, probably a week or a day or two of flexibility. and training and stability training, that's kind of bare minimum. If you can do that, you're going to maintain your health and be good for a long time. You've said in the past that strength training is the best anti-aging medicine. What's still good about it? Because what you're doing is you're building muscle, you're building mitochondria, your increasing muscle mass, and what really

kills people is frailty. When you get older, you get frail, you're not able to get up out of a chair, you're not able to do that you love to do. Your mobility is decreased, your functions decrease. that's all totally preventable by strength training. And you have to work harder as you get older because the body doesn't really, unfortunately, it doesn't work as well. So you have to do a little more effort to get the same benefit. And I think that's, you know, that's something people have to do. But it's not optional.

Exercise is just not optional. I agree. Okay. Last question for you. And then we're going to close out this interview. So the average listener's age on my podcast is 35 years old. And they're typically an entrepreneur. So let's say it gave you a 35-year-old, they're stressed, exhausted, running on coffee.

If you had a year to transform their health and performance, what are the things that you would change? I would immediately have them get on a Whole Foods diet that I just talked about. I'd have them just follow the principles that would be real food, low sugar, starch, good fats, adequate protein for where you are in your life phase, and varies depending where you are, lots of phytochemicals, lots of fiber, and just start there. And if you're really having any help issues, I'd probably do my 10-day detox program, which is essentially a reset.

It's just 10-Detotx.com with a 10-day detox. And what really is amazing about it is that people get a reset. It's like putting your body back to its original factory settings, and you can see where food is impacting you. Oh, I didn't know that, oh, my rash was caused by food, or I didn't know that my migraines or caused by what I was eating, where I didn't know that my joint pain was caused over the other thing or my sleep problem was caused by eating. So you get a really quick reset, and then you can start to have foods back in.

So that would be number one, get your food straight. And that's timing, planning, organizing. It's really important. The amount of time you spend on your business, fract that you spend on your health, you'll get a lot of dividends from that. You get in the regular exercise your team, not that hard. Just want to walk 30 minutes. If you walk in phone calls, that's good, better than nothing.

I'm going to have a walking treadmill. you can do more fun things. I like to bike. I like to do more, more mountain biking and road biking and tennis and other things that kind of are fun for me. I like to make exercise fun. String training, I've gotten into more and more. And it's been profound in terms of effect on my body, even as I'm older.

I think learning how to regulate your nervous system is important. You know, self-soothing is not something we learn how to do. We get activated, reactive. But learning how to practice, whether it's breathwork or meditation or some practice. where you're resetting your nervous system because we're all on parasympathetic deficit. We need to be relaxing more. And then I think build community because, you know, as you're building something and going through stuff, you know, when getting isolated is the worst thing you can do for a human

being. And so I think having that ability to sort of work with your friends to kind of build a fun community experience is really important. And that's something that, you know, it's been really important to me, especially as I got older, it's just invest in your friendships. Because when everything else goes, that's what it'll be left. Totally. Yeah. So that was great advice on an individual level. And a lot of the people tuning in are entrepreneurs and we help move society forward. And, you know, we have this big shift from traditional to functional medicine. We're trying to combat the food industries. Can you talk

just about some of the opportunities that you see for entrepreneurs to kind of capitalize on all these changes? Well, I think, you know, the health and wellness market is a billion dollar market. And, you know, there's a lot of ways people are entering that. But you can figure out, you know, what you love and the intersection of what you love and, you know, what people need. Often businesses are started from people's own needs. Like I need to fix my own help. So as a physician, I got very sick when I was in my 30s. I got chronic fatigue syndrome from heavy metals.

And I was struggling a lot. And I had to actually sort of figure it out. And that forced me to learn about what I learned about. it forced me to study the way I studied to actually find this field of functioned medicine, to use it in myself, to heal and repair. And so that's kind of what I'm originally to do, is figure out that intersection of what you love. That's just driven me because it's not like a choice. I don't have a choice.

It's not like I'm making widgets or something. It's fine to make widgets. We all need widgets. But the key is really to kind of figure out how you can do this in a way that it seems with what you love, because otherwise you won't really do it. Great advice. Okay, so I end my show with two questions. I ask all my guests. It could be, like, totally different from what we talked about today. Just answer from your heart. So what is one actionable thing our young improfitters can do today to become more profitable tomorrow?

Well, what your success is really determined by the quality of how you feel. So if you're able to function at high level and do the things you want to do and not be held back by illness or struggles, you're going to be able to function at a much higher level and do whatever you want to do, whether it's just kind of buzz off and go kind of get early retirement or whether it's who want to build a company or whatever you want to do, you know, you have the capacity to be highly functional when you feel better. And so investing in your health is such an important thing. From my perspective, you know, I see a lot of people who have great businesses and companies

and they build these things, they're rich, have all this stuff, and they're lonely, they're isolated, they're unhealthy, they're sick, they don't feel good. I mean, that's the last thing you want, right? Totally. And your book Young Forever really is just like a blueprint for how to do that. Absolutely. Yeah. And what would you say your secret to profiting in life is, and this can go beyond business? I mean, the secret to profiting in life, again, is to focus on the things you love and to do what's you're passionate about because, you know, if you try to force something in your life, you know, the best thing that happen are often serendipitous. They're often, they're often come to, their ideas, their people, their experiences. I feel like there's sort of an underlying kind of

current where we can kind of jump into it. And if we're, if we're present, well, we're able to see actually what pulls us in. And when we do that, you become more profitable. I've never, I've never sought to make money in my life. I've never tried to make money. I've never said, I'm going to do a business to make money. I'm going to do this to make money. I'm doing what I'm doing because I feel like it's critical for myself and for the people who I care about and for the population at large. It's like I just can't help myself.

So I think when you do that and you have a mission and you're driven, then it's not about the money. Love it. And Mark, where can everybody learn more about you and everything that you do? I know you're so easily found, but where do you want to point people to do? Well, you go to Dr.heimen.com. If you want to try the 10-day detox, you go to Dr. Hyman. Don't tell me you'll find it.

Everybody's just go to 10-day detox diet. I'm on social media, Dr. Mark Hyman, and I have a podcast, the Dr. Hyman Show, the top 200 podcasts out there. So it's doing well. Awesome. Cool. Thank you so much for joining us on Young and Profiting Podcast. My pleasure.

My pleasure. Hey, yeah, Bam. We're about to launch something that might be my favorite thing we've ever done on the podcast, a brand new series called How We Profit. Now, I've been doing Young and Profit. profiting podcast for eight years. And my listeners are successful. We are real entrepreneurs with real businesses and a lot of you guys are crushing it behind the scenes. You may not be super famous. You may not be a billionaire yet, but you've got a business that you've learned how to

scale. And we want to hear from you. One of the best ways to learn as an entrepreneur is from your peers. And I found it super helpful to be in these peer entrepreneurship groups and learn from other entrepreneurs who are at my level, but just in a different industry. So that's why I'm what I want to bring to this podcast. I want this to be our own peer group, but on the podcast. And so I'm going to be interviewing people who are making anywhere from $500,000 to $10 million a year. They're not super famous. They're not the typical billionaires that are on my show. These are real entrepreneurs who are crushing it behind the scenes, and we're going to uncover what they do to sell, how they get their customers, what their profit margin looks like,

how they market, and so much more. If this sounds like you and you want to be featured on Young and Profiting Podcasts for our How We Profiters, series, just head up to young and profiting.com slash apply and share your story. Let me know why you think you should be featured on the show. Again, that's young and profiting.com slash apply. And who knows, maybe you'll be our next guest on Young and Profiting Podcast.