ZOE Science & Nutrition - The truth about menopause supplements

Episode Date: June 29, 2023

More than half of women who go through menopause find its symptoms distressing. In fact, 10% leave their jobs because of the burden. It’s no wonder that a huge selection of supplements claim to relieve menopause’s unpleasant effects. But do they actually work? Which products are backed by clinical evidence, and which are just “menowashing”? In today’s short episode of ZOE Science & Nutrition, Jonathan and Dr. Sarah Berry ask: What’s the evidence behind menopause supplements? Follow ZOE on Instagram: https://www.instagram.com/zoe/ Download our FREE guide — Top 10 Tips to Live Healthier: https://zoe.com/freeguide Mentioned in today’s episode: Introduction to menopause from John Hopkins Medicine What is menopause? from The National Institute on Aging What you should know about hormone therapy and menopause from the Columbia University Irving Medical Centre Menopause symptoms in depth from the National Center For Complementary and Integrative Health Menopause supplements: Effectiveness, side effects, and safety from Medical News Today The role of diet in managing menopause symptoms from Nutrition Bulletin Revealing the evidence-based diet solutions to managing your menopause symptoms from Nutrition Bulletin Episode transcripts are available here. Is there a nutrition topic you’d like us to explore? Email us at [e-mail] and we’ll do our best to cover it.

Hello and welcome to Zoe Shorts, the bite-sized podcast where we discuss one topic around science and nutrition. I'm Jonathan Wolfe and today I'm joined by Dr. Sarah Berry. And today's subject is menopause supplements. So almost every woman goes through menopause. It's a natural part of aging, but it can come with really serious symptoms that severely impact our day-to-day life so it's no surprise that people are turning to all sorts of supplements for relief so that makes sense sarah i guess the question is do any of these menopause supplements actually work well menopause has been hugely understudied in the past and women are still really underrepresented

in health research so there's a lot we don't know, but there is a picture emerging. So let's hear more. So Jonathan, the menopause is the point in time when a woman's periods have stopped for 12 months, which on average occurs when they're 51 years old. But actually there can be many years leading up to this point, which we can call the perimenopause phase. Now, imagine a woman in perimenopause where she is in a stage of this hormonal chaos, as I like to call it, where she may be experiencing a whole host of symptoms like hot flashes, night sweats, poor sleep and poor mood. And Sarah, every time I hear about this, I'm just amazed at how this was never discussed as I was growing up.

So what's going on in someone's body that brings about menopause? So during the perimenopause phase, oestrogen and progesterone fluctuate and their levels go up and down in a quite unpredictable way, causing this hormonal chaos. And so Sarah, is it that change in these hormone levels sort of going up and down that's causing a lot of these symptoms? It is, but also women do experience many of these symptoms after the menopause where these hormone levels have reduced but have stabilized. Got it. So it's not just like going up and down, it's also when you just like lost the level of oestrogen that you used to have had before. So let's talk some more about these symptoms then. What are people dealing with?

Well, Jonathan, we actually have some of our own data from the Zoe Health Study, which is the biggest study of menopause and nutrition in the world. Now, hot flashes may be the most talked about symptoms, but when we looked at over 8,000 women in perimenopause, we found that sleep disturbances were the most common symptoms reported by 82% of women. 82%, Sarah, that's enormous. Jonathan, that is absolutely huge, especially considering how many women at any point of time are in this perimenopausal phase. Now, Jonathan, we also found that more than half of women experience brain fog, anxiety, weight gain, low libido, joint pain, and memory loss. I mean, as always, Sarah, I'm just stunned by how many women report really serious symptoms.

I mean, every single one of those symptoms was more than half the people. Am I right that from this study, we also discovered for the first time that women who have a worse diet quality are more likely to experience these symptoms? Yeah, so what we found was that those who had a healthy dietary pattern had about 30% less likelihood of experiencing hot flushes and sleep disturbances and about 20% less likelihood of experiencing brain fog, joint pain, anxiety, or low mood. Interestingly, Jonathan, we also found that people that were living with obesity were

also much more likely to have these symptoms. So, for example, those people living with obesity had nearly two times greater likelihood of experiencing brain fog or headaches compared to those who were normal weight. And these symptoms sound really difficult to cope with. Just how many people have been affected? Yeah, unfortunately, they're really widespread. And we've just seen this from our own data. And this is really relevant if we consider the fact that 30% of the female population are peri or post-menopause at any point in time.

So we're talking about a lot of people. Yeah, and what's really alarming is almost half of those women find their symptoms distressing. And even 10% of women leave their jobs due to the burden of their menopause symptoms. So you can see why people would be desperate for a quick fix. Right. And it's a $5 billion industry at the moment, and it's growing rapidly. People are trying all sorts to combat their symptoms. And there's even this term called menowashing. And basically this means stick the word menow in front of the product, whether it be a food supplement, a skin cream, and you can double the price and sell more. So people are trying anything. And a recent survey showed that 30% of people are trying

herbal remedies, 30% are trying vitamins, and 51% any kind of dietary therapy as an alternative to HRT. And then Jonathan, of course, there is HRT as well. So you and I discussed hormone replacement therapy, HRT, in a previous episode with Professor Joanne Manson, who led some of the huge clinical trials that looked at HRT. So if you're listening to this and you haven't heard that podcast, I think you might find that really interesting. My very brief summary would be that Joanne said HRT replaces the missing hormones and can be an effective treatment for menopause symptoms for many women, but it's not necessarily the right choice for everyone. Would that be about right, Sarah? Yeah, that's right, Jonathan. And a key focus of my research here at Zoe is to look at how diet may impact menopause symptoms and also health in post-menopausal women.

And so outside of changing your diet and HRT, there's loads of supplements out there. Black cohosh, flaxseed, red clover, ginseng, St. John's wort. I'm just listing a few of the supplements that are sold for menopause here. That's a lot of supplements. Do they help people get any relief? And what's the actual clinical evidence? So interestingly, if you search up the evidence around menopause supplements and symptoms, what you see is there's about 500 clinical trials that have looked at a whole array of different supplements and menopause symptoms. But despite this, there's actually not a lot of good evidence showing that dietary supplements can relieve menopause symptoms, and there's no consensus of the evidence. So studies on black cohash, which is derived from a herb, have very inconsistent results.

There's uncertainty around the effects of vitamin E. And again, there's really limited and very inconclusive research into evening primrose oil, ginseng, melatonin, wild jam and many of these other supplements. As Zoe's chief scientist I wanted to talk about something that's not talked about, menopause symptoms. Over half of people on the planet experience perimenopause and menopause, yet symptoms are often misunderstood or dismissed. Zoe's new Menoscale calculator lets you score your menopause symptoms. Your Menoscale score may help you make sense of what you're experiencing. Personally, as a woman experiencing perimenopause, it's a key talking point with my friends. And now we have a score that we can share with each other.

To me, this calculator is a game changer. At Zoe, we're moving menopause research forward. We recently conducted the largest research analysis of menopause and nutrition in the world. In our research, participants reported an overwhelming number of symptoms. 66% of perimenopausal women reported experiencing over 12 symptoms like weight gain, memory problems and fatigue. The good news is our research shows that changing our food habits may reduce the chance of having a particular menopause symptom by up to 37% for some women. The Menoscale calculator puts our science in your hands. Go to zoe.com forward slash Menoscale

to get your score. The calculator is free and only takes a couple of minutes. As we scientists say, if you can't measure it, you can't change it. All right, back to the show. So none of this sounds very promising for the many people who are listening to this show who might be suffering with these symptoms or know someone who is. I agree. But I do think where things start to get interesting is the science and evidence around phytoestrogens. Phyto what exactly, Sarah? So phytoestrogens are natural substances that come from plants, but their chemical structures are really similar to oestrogen. So they bind to the many, many different oestrogen receptors that we have spread throughout our body. And they're a family of compounds of which the most studied is a compound called isoflavone. Isoflavones are found in many plants, but they're found in particularly

high concentrations in soy, as well as being found in flaxseed and red clover. And how might these isoflavones affect menopause symptoms? Well, firstly, we know that isoflavones can mimic the effects of oestrogen by binding to the many oestrogen receptors that we have in our body. Secondly, we know that populations that have a high intake of soy isoflavones, such as women in China and Japan, have much lower incidence of menopausal symptoms. So for example, as the intake of soy goes up in a country, the rates of symptoms go down. And to put this into context, the average intake of soy isoflavones in the UK and the US is less than half a milligram a day, whilst in China and Japan is anywhere

between 20 to 70 milligrams a day. Wow. So that's 50 to 100 times higher in sort of China and Japan compared to, you know, the UK or the US. Yeah, absolutely. Well, that's great news then, Sarah. So should we just be giving everyone these isoflavone supplements? Well, Jonathan, as you know with me, there's always a but. And this but is that the clinical trials of supplementation are actually quite inconsistent. And do we know

why they're inconsistent? Yeah. So there's been more than 60 clinical trials investigating the effects of isoflavones on symptoms and hot flushes in particular. Now some show a benefit but some don't and if we try and work out what's going on by looking at all of these trials together what we see is that the type and also the dose of isoflavone is important. Okay so what type of isoflavone and how much should be people taking if they want to get this benefit? Okay so firstly let's look at the types of isoflavones. There's two main forms. There's genistein and diadzein. Some of the evidence shows that a dose of more than 15 milligrams of genistein a day is the most effective at reducing

symptoms. But where it gets even more interesting, Jonathan, is that we also find that some individuals respond more than others to isoflavones. And this is because the gut microbiome is involved in metabolizing isoflavones into their very active form, which is called EQUAL. And it's the really active form that binds really strongly to the estrogen receptors. Just to make sure I've got it, Sarah. So I eat this food, like let's say I'm eating lots of soy, it's got this isoflavone in it. Then actually my gut microbes are breaking that down and actually turning it into like the active chemical, a bit like a medicine that's going into my body and really affecting me. Is that right? Yeah. So the isoflavones are active as

you consume them, but they become even more active if they're converted into Equal. And some people have the bacteria to convert them into this kind of super active form and some people don't. So we know this varies from person to person. So we know, for example, that people in Asia produce Equal. So about 40 to 60% of people have the gut microbiome that enables them to produce equa from isoflavones. And this compares to the UK and the US where only about 20 to 30% of people have the gut bacteria that converts the isoflavones into this really active equa form. Just thinking about everything you've just described, I'm suddenly thinking about a very recent podcast that we did on ultra processed food with Tim and Chris,

and they were saying that almost every time that scientists try and extract a single active ingredient from a food to make a supplement, it tends to fail in clinical trials, whereas the whole food works. And usually this is because the idea that there's one single chemical in this food that is responsible for all the health properties turns out to be wrong and so when you just remove the whole food you just go to this one supplement suddenly you do this study and you don't get the results. Is it possible that we're in the same direction here so we're thinking about supplements of this one chemical instead of saying let's eat the soybean and these other whole foods that are creating these benefits that we see in Asia? Well, I think it's clear that in some populations, such as Japan and China, people can get enough of these isoflavone compounds from foods naturally

that are in their diet. But in the UK and the US, it's actually quite hard to get a decent amount of these at that effective dose that I mentioned earlier. And so I do think that for UK, US and other populations that aren't getting enough from their foods, they may want to try supplements. And I do think that the evidence that I mentioned that has used isoflavone supplements is reasonably consistent at that dose of 15 milligrams of genistein a day. And final question, since this area is still being researched, what do we know about the long-term safety of phytoestrogens? So I think it's still something we're learning a lot more about. We need to study more. There have been questions regarding the safety of phytoestrogens in women that may have had certain cancers that are impacted by oestrogen i think so far the data would show that as long as we're not mega dosing just like we shouldn't be mega dosing in my opinion on any supplement vitamin or mineral that there seems to be safe

but as always I would caution people on megadosing and watch this space for further research. So Sarah, what can we take away from all of this? So I think, Jonathan, it's very clear that menopause symptoms are really prevalent, that a huge proportion of women who are perimenopausal but also postmenopausal suffer from very burdensome symptoms across a whole range of different symptoms that are really distressing for many women. I think that it's very clear from the evidence that improving your overall dietary pattern, so having a Mediterranean style diet with plenty of fruits, vegetables, unprocessed plants and a variety of different plants is going to improve your symptoms and maintaining a healthy weight.

I think that the evidence for most of the supplements that are marketed is incredibly weak. And I think that the only evidence that's good enough to suggest that there might be an improvement is from isoflavones. And my personal opinion is that if there's a supplement that's got menno in front of it, a skincare product that's got menno in front of it, a hair shampoo that's got menno in front of it, it's simply menno washing and it's washing money down the drain that could be better spent elsewhere. I guess maybe to wrap up, why are you personally so excited about your research around nutrition and menopause? It's something all my friends are talking about. Everyone's talking about HRT, the pros and cons. Everyone's talking about, oh, have you heard there's this latest supplement

out there? And these are friends that are incredibly well-educated, but unfortunately, all of the marketing out there around these menopause supplements is so powerful. And so, you know, I'm really committed through our ZOE research to really try and unravel what it is about different diets, different foods and different food chemicals that may be able to reduce some of the burden of these symptoms. If you'd like to see whether Zoe's personalized nutrition program can help with your menopause symptoms, you can get 10% off by going to joinzoe.com slash podcast. I'm Jonathan Wolfe. And I'm Sarah Berry. Join us next week for another Zoe podcast.