Mind Pump: Raw Fitness Truth - 2017: The Best Peptides for Fat Loss With Dr. William Seeds

Episode Date: February 23, 2023

In this episode Sal, Adam & Justin speak with peptide expert, Dr. William Seeds. A brief background of Dr. Seeds. (2:34) What are peptides? (4:09) Did he see the writing on the wall? (7:13) What makes them different from drugs? (8:44) How hormones are psychologic. (13:58) The biggest issue he sees with people’s inability to lose weight. (20:30) How peptides can influence fat loss. (24:30) The benefits and science behind GLP-1 receptor agonists. (27:08) Improving muscle mass to save lives. (30:22) Why diet is so crucial when it comes to weight loss. (34:02) What GHRHs (Growth hormone-releasing hormones) do and how they can impact fat loss. (41:23) If you're not doing resistance training, why are you training then? (48:38) The most beneficial peptides for “most” people. (51:47) The importance of going through a doctor when using peptides. (1:02:29) Life is handled in the weight room. (1:07:09) Related Links/Products Mentioned For Mind Pump listeners only Equi.life is offering a FREE BOTTLE of their best-selling liquid Vitamin D3 going on right now. Special Promotion: MAPS Anabolic Advanced Launch for only $97! **Code AA60 at checkout** (Ends February 26th, 2023) February Promotion: MAPS Performance, MAPS Aesthetic, and MAPS HIIT are all 50% off! **Code FEB50 at checkout** MP Hormones Mind Pump Hormones Facebook Private Forum GLP-1 agonists: Diabetes drugs and weight loss - Mayo Clinic Semaglutide – The International Peptide Society FDA Approves New Drug Treatment for Chronic Weight Management, First Since 2014 Growth Hormone-Releasing Peptides (GHRP) Deep Dive Sermorelin Dosage Calculator and Guide | What You Must Know AMPK: guardian of metabolism and mitochondrial homeostasis The Resistance Training Revolution – Book by Sal Di Stefano BPC-157 Benefits | What You MUST Know The extracellular matrix and cell wall (article) | Khan Academy Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats P-1114 - Rapid and slow response during treatment of generalized anxiety disorder with peptide anxiolytic selank Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells Mind Pump Free Resources     Mind Pump Podcast – YouTube Featured Guest Website – Dr. William Seeds  

If you want to pump your body and expand your mind, there's only one place to go. MIND, MIND, MIND, MIND, MIND, MIND, with your hosts. Salda Stefano, Adam Schaefer, and Justin Andrews. You just found the world's number one fitness health and entertainment podcast. This is Mind Pup, right in today's episode. We talk about the best peptides for fat loss with Dr. Seeds. He's one of the experts, one of the best experts in the world on the effects of peptides for fat loss with Dr. Seeds. He's one of the experts, one of the best experts in the world on the effects of peptides.

This is a very cool segment of medicine. Peptides are not drugs, but they have effects on the body like drugs, but also a lot less of the negatives. Very interesting episode. We learned a lot. It's really cool. So we talked about peptides that help with fat loss,

boost growth hormone. It's really cool. So we talked about peptides that help with fat loss, boost growth hormone. It's a fun episode. By the way, if you want to learn if peptides are right for you, first off, you got to work with a doctor. You should work with a doctor. So go to mphoromones.com, talk to the experts there to see if peptides, like the ones we talk about in today's episode, are right for you.

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here comes a show. Dr. C, welcome to show. Thank you for having me. No problem. So if, if you don't mind introducing yourself a little bit to the audience, it's kind of letting people know your background a little bit before we get into the topic, which are peptides. Sure. Well, I guess first and foremost, I like to say I'm an awesome father. I've got three boys that I raised that, you know, it's all about raising your kids and then hanging out with them the rest of your life and I think I've done a good job with that and And then I'm a physician. I'm an orthopedic surgeon sports train joint train, but my real expertise is

cellular medicine and specifically to What makes up the biochemistry molecular biology biology, quantum physics of the cell, and how do you optimize it? How do you keep it in check? And how can I utilize all that knowledge to help my patients and help myself to keep up with my kids? So it just kind of circles around all of that

and optimizing what I can do for people that have issues, metabolic issues, immune issues, cancer, and optimizing performance. So it all kind of circles around knowledge of the cell and I've just been fortunate to been doing that for 40 years. And I'm 61 and I walk the talk. I'm all about training and optimizing cellular health. Excellent. Okay, so talk to us a little bit about peptides. I'd say over the last, I don't know, probably came on our radar over the last 10 years, but really over the last five years, we've heard a lot about peptides and their benefits

in how they're being used. More recently, we've been using some peptides and have noticed some pretty amazing benefits. And of course, we're being monitored by a doctor, which I think is probably what you would recommend as well. But what are peptides and how do they fit in the, I guess in the medical market? Because I know some people can get them online

without necessarily having to go through a doctor like, let's start with peptides in general. What are they? And then let's get into, I guess, how they're available and what they do. Sure. are basically amino acids that are combined from... It's a combination of amino acids that are either connected in straight lines, helixes, circles, whatever you want to call, you know, the amino acid sequence. to call, you know, the amino acid sequence, it's basically a signaling agent that is in this context of what we're referring to and what we're, what, how this all started is the context of these are signaling agents that the body is familiar with. It's how cells

communicate, it's how communication between organs, it's basically the understanding of how cells talk to each other to optimize or adapt to the environment. So peptides really, I actually, so I introduced peptides about eight years ago in, in the context of teaching to physicians to understand really, we just, I brought peptides out as just a basis of understanding molecular pathways because they were familiar to people. We had some of them that we were utilizing in treatments and modalities, and then it just exploded. So I think now it's just amazing to see where it's gone. When basically the whole context of starting, the discussion of peptides was to really teach people about molecular pathways and cells and how they communicate. It just seemed like the logical step to take,

to understand that peptides are just naturalist signaling agents that the body's familiar with. And thereby having less side effects, less issues with tolerance or resistance to the receptors. It just made sense to start with that and Go from there to start teaching about the utilization of these signal agents What were some of the original peptides that hit the market and when they did Did you kind of see the writing on the wall?

Did you know that it was going to explode like it has was it was it obvious the direction it was going? Did you know that it was going to explode like it has? Was it obvious the direction it was going? Oh, absolutely. I mean, so what people don't know is when I first started lecturing eight years ago, I'd ask the audience physicians, I'd say, so how many of you are using peptides? Nobody raised their hand and I said, well, does anybody use insulin? Insulin is a peptide. It's one of the first incredible signaling agents

that we've ever changed life. It changed life as we know it. And just using that starting point to indicate the significance of the signaling agents was a great way to capture at least my audience at the beginning. And so, I mean, so we've had insulin oxytosis and vasopressin, we've had all of these peptides around for 80 years.

They've just been progressing in knowledge of synthesizing some of these peptides that we have and then being able to utilize them, study them and look at the clinical significance. And it's exploded into hundreds, if not thousands of peptides that we're familiar with right now that have clinical relevance. You said some really interesting interesting that caught my attention. You said that they are signaling agents that the body is already familiar with. In other words, peptides are based off of signaling compounds that we already have in the body. Is this what makes them different than drugs? Like what's the difference between a drug that, let's say,

agonizes a receptor or antagonizes a receptor versus a peptide? Well, yeah, so in this context, so we can make any peptide, a peptide can be any combination of amino acids. So we can make anything, the library is infinite. But if we look in the body, the human body, and we look at how cells communicate, how does a mitochondria communicate with the nucleus, how does a nucleus communicate with the mitochondria, the proxysome, the Golgi bodies, all the things that make up proteins, well, they do it through peptides. And peptides are basically, they're in and out of the body pretty quickly. They're signaling agents that could be there for seconds, they could be there for a couple

of minutes, and some longer. And that's where science has gone to where we can keep them around longer. That's why they're more relevant now because we can make them hang around to do their job when we introduce them exogenously, meaning by pill form, nasal form, injectable form, transdermal form, whatever. But the significance is that the cell is familiar with the signaling agent. So it doesn't see it as a foreign, as some kind of foreign process of where we're forcing a cell to do something it does not want to do.

These are all agents that allow a cell to use its intelligence which is incredible and we'll never have that intelligence. It lets the cell have its own ability to utilize these signaling agents then to make decisions, you know, as far as adapt, you know, like you guys are, you guys are all about exercise and so forth. So what is exercise and what are you trying to do? You're always trying to have the muscle adapt to the environment of what you're presenting. And these peptides just help that signaling and communication between cells become more efficient.

And at the same time, utilize substrates like glucose, fatty acids, proteins in a more flexible pattern so we can optimize glycolysis or oxidative phosphorylation or fat oxidation when it's needed. So we're not forcing a cell to make a decision with a drug. We're giving the cell its intelligence to make amazing decisions when they need to be made. So you get, so with something like this, is it safe to say that you would see less of a potential negative feedback loop or a tolerance or receptor down regulation or some of the ways that the body adapts to drugs where you tend

to build a tolerance or you tend to your body almost adapts and it starts to become, you need more to get the same effect, you end up with more side effects. Do peptides do less of that? Well, so that what you've indicated is basically when you get something that is hanging around too long or something that's there that is not physiological, okay? That you're introducing something that's non-physiologic. Typically, with all of these peptides,

we're introducing signaling that's physiologic to get a physiologic response, not a super-physiologic response. So we're introducing something that will not cause inceptor evolution, will not cause immune reactions, will not cause tolerance, will not cause, it's again, it's if you use these correctly and you understand how to use them, and you know the signaling of the cell, it's pretty straightforward with just letting again the cell make the decision. On really how is it going to utilize a substrate and how is it going to make ATP and NAD and it really comes down to that into energy so that's really it and that's what's so phenomenal about now and the craze of where we're going, especially

pharmaceutical companies now. Their focus is on peptides because they're natural. They don't have to do, they don't have to find the mechanisms because we already know them. It's now let's synthesize them. That's where this is going. So this is why it's exploding and less money has to be spent, less research, less and then less side effects. Side effects is the big deal with this because again, body familiar with signaling.

Now, in terms of, so the hormone space and exogenous hormones. The potential for peptides in terms of being able to signal the body to produce this balance and get your hormones up together naturally is that their potential there in terms of less side effects, less dependency on exogenous hormones and being able to pursue that instead. Okay, that's a loaded question. But it's a great question. It's a great question because there's so much there that I could talk to you about five hours straight about. So let's just jump in and say, okay, hormone supplementation tends to always be super

fizzy logic. So I don't care what anybody tells you, I don't care what anybody says out there, it is a fact. And it's difficult to monitor and keep if you are supplementing with some type of energy or hormone, it's very hard to, to number one, to keep it in a physiologic range for the most part because the patient or the person always wants more, right, especially in muscle building and so forth. But I'll tell you,

let me back up and say that peptides, depending on what you're trying to help the cell work with. And that is typically efficiencies. Efficiencies are in mitochondria, nucleus, DNA, transcription, all these things that we do to make a cell smarter and better. Well, that leads to improved testosterone production, improved growth hormone production, improved IGF-1 production. All the things that are important in particular

in what you're potentially interested in muscle building and recovery and restoration of function after training, it comes down to really efficiencies of the cell. So I can see people that have come in and say, hey, Doc, I've got low T. I mean, I hear that all the time. And they could be their mid-30s. They could be 40s, they could be 40, 50s, but there's so many things that can be leading to that low testosterone that may not even be, even low testosterone may not be an indicator

that they're having these problems with fatigue and recovery and all the things that go along with that open-ended subject that's tremendous, right? That's huge. What I'm trying to say is, you've got to look at this from a really broad perspective of, look, you can take numbers, if you're dealing with a number, then you're done. I don't, you're not gonna get anywhere

making yourself more efficient or making, improving the efficiencies of the cell. It's all based on multiple pathways of working to get to a place that has to do with improving acid-based metabolism of cell, has to do with improving the microbiome of the body, has to do with, oh, you know, the circadian rhythms of your sleep. I mean, there's so many of these factors, I'm sure you guys are all aware of that come into play with recovery and restoration of function. They have everything to do with the diurnal patterns of testosterone production, estrogen, progesterone, prolactin. I mean, all of these they end and the master hormone, growth hormone. And that tends to be, if we're on the peptide side of things,

that tends to be one of the areas that we really focus on first because of so much of the knowledge of what happens to endogenous growth hormone production. And that's meaning the anterior pituitary producing your growth hormone. And it cycles it anywhere from three to nine times a day. It's interval pulses or three hours apart. It's all about how can I influence that master hormone potentially in being an influencer on other things like downstream IGF-1, on testosterone production on other hormones.

And you know, that has to do with age, it has to do with environmental factors, it has to do with stress, all kinds of things. So, those are approaches that can be taken and more specifically and elderly individuals, you know, when you reach the 40, 50 years of age, I mean, you're producing, at 50 years of age, you're producing almost less than half of the growth hormone you did in your 25 to 30 range. That's a significant amount of growth hormone where the anterior pituitary is is Absolutely able to mechanically produce growth hormone into your hundreds and it's all about understanding what happens during life to

influence that production. So so if you can keep physiologic production of some of these hormones that peptides influence, so we're talking about hormones now, we can talk about enzymes, we can talk about DNA transcription, we can talk about RNA turns. We can talk about any of these things of what these peptides can do, not manipulate, but influence a cell and how it decides to produce, like in your testicles, to produce testosterone. So there, I could just keep going. I mean, you can talk about an adetrofen releasing hormones, you can talk about chispeptin 54, chispeptin 10, you can talk about Kispeptin 54, Kispeptin 10, you can talk about a lot of these signaling systems

to our signaling agents to help you, depending on where is this person at and what do we think is influencing the possibilities of why they're in your case, why are they not recovering well? Why are they fatigue? Why are they tired? Why are they, you know, they're training, they're doing all these things, they're supposed

to be doing. Why are we not reaching at these levels? Why are we not getting the fat loss we want to see? So it's really just, again, using the brilliance of molecular pathways to influence those type of things that make a difference in the cell. Let's talk a little bit more about the fat loss side and some of the most common challenges that we see

and what peptides are you seeing or benefiting that person. So you got a client who's stalling their progress. We all know that it could be a whole host of things, that could be causing that. But where are you seeing the, you know, introducing a peptide's being most beneficial for that avatar, that person who's struggling

with fat loss? Yeah, there's one in particular, I'm hearing a lot about some of Glutide, I've been reading and hearing a lot about that one. Like what's going on with these and how are they working? OK. Well, let me just back up and just and let me see if I can set the the lay the platform that then jump

into the GLP1 receptor agonist. You're talking about semi-glutide. Um, it so so fat loss is all about, it really comes down to glucose absorption, the utilization of glucose through glycolysis, and through the full oxidative respiration, meaning oxidative phosphorylation crepocycle to make ATP and NAD. What does that mean? It just means that as we train harder,

as we eat poorly, as we environmental factors, whatever they may be, stress, so forth, all these things influence the cell, what was called cell redox, and how inflammatory things influence the cell, what was called cell redox, and how inflammatory aspects of the cell can then influence the way the cell uses what you put into your body, like fat or proteins or glucose. So what happens is the body loses its flexibility, the cells lose the flexibility to make those decisions

of when do I use this substrate to make energy? And so what happens with fat loss is we tend to lose oxidative phosphorylation, meaning the most efficient way we can make energy is by utilizing fat. That's why ketone esters are the hottest thing in sports because it's just an immediate NAD ATP production that bypasses everything and it's just incredible. That's something else we can talk about at some time.

But the bad oxidation is so important in the maintenance of the cell and how it produces NAD and ATP. That's like people who take all these supplements and stuff. They just wipe out cell respiration. They take too many people to take so many of all this bullshit that just ruins the cell redox state to where they can't lose fat, they can become insulin resistant, they can't make muscle gains because they think they're doing things to make the cell better because they're taking an antioxidant where there's this small window of how that works.

And, you know, like always, a little bit of something is good, too much is something that's good is bad. So loss of fat comes down to really just understanding those basics. And then you know, you're fasting, you're exercise program, all these things that can be beneficial, but probably the most, you know, in my line of work, what I do to optimize performance and take care of immune diseases and cancer and so forth. You know what? My biggest problem is it's the diet. It's seeing this diet that's high in everybody has this low grade metabolic acidosis and a low grade metabolic acidosis is always going to influence sarcopenia, lots of muscle mass. It's going to decrease fat oxidation. So those are some of the basic things that

you have to work on first and then if we get into the peptides, then it's about optimizing fat oxidation. So how can we do that in a control fashion? Well, as I talked about before, endogenous growth hormone is one of those things that we have a lot of data on and know how we lose it. We know how it's influenced by disease states, in particular, low grade metabolic acidosis or insulin resistance. It lowers the amount of growth hormone release. So we can do things while we're working on a program to influence better nutrition, better sleep, and exercise, resistance or cardio or high-intensity interval training.

Using those in conjunction with, say, like a GHRH or GHRP type of peptide, we can influence growth hormone, endogenously, to release like it should, to take advantage of what it does. And that's all about body partitioning, improving, fat oxidation, using fat as your main source of energy, letting you store glucose and use it a little bit later, And then getting that mechanism of there's this mechanism of how insulin influences this this PIPK AKT, MTOR pathway of building muscle or building protein, you know, making protein and so forth. So this has an influence. If you're improving efficiencies of the cell, you're going to influence MTOR. You you're gonna influence, emtory,

you're gonna influence that process of protein synthesis. So, at the same time, you're losing fat, you wanna improve protein synthesis because on that side of it, the more muscle mass you have or the more efficient the muscle mass you have, theoretically, and it depends on the type of exercise you're improving mitochondrial capacity function optimization. So you're going to utilize energy even better, right?

And so you're going to consume that cells going to want to consume more energy. So all of a sudden you've got this reserve of muscle, you've lost fat and you've improved efficiencies of the muscle to where you're thriving now on that fat oxidation. So that's the beginning of trying to help people in losing 5 to 15 pounds of body partitioning basis, basically of fat to muscle. And then you can get into, so then it's gone into, you bring up the GLP1 receptor agonist like semi-glutite. So I started lecturing on that about six years ago

on these GLP1s. And GLP1s at the time were introduced, we studied these as neuro-ognitive type of peptides that were involved in, we were looking at them in Parkinson's and Alzheimer's and all of these ways we could improve executive function cognition, neuroplasticity. And what we found out is that people were losing weight and going through the mechanisms, we understood that it had everything to do with improving insulin and improving beta cell function, the pancreas, and then, okay, right on that, big pharma jumped on and said, well, diabetes, big single world, let's go.

And so the focus went off the brain and went right into diabetes. And so we had these incredible peptide agents that have been phenomenal in changing how we treat type two diabetes. And in fact, even some type one issues. But what was the side effect of these? The side effect was weight loss because you were improving with GLP1 receptor.

So GLP1 receptors, like semi-glutide you brought up, they're all different names, but they're all GLP1 receptor agonists. They're made in the stomach. They're made by a particular cell that produces them based on when food comes into your body and you release this. Well, that gets influenced by disease, fat,

all kinds of things. And so all we're doing is introducing more of that peptide to do its job in improving again, fat oxidation. But it has many other pathways. So I haven't talked about what's wonderful about these peptides, is it's not just one pathway. They have pleotrophic pathways, meaning many ways to get things done efficiently to make a cell better. And in particular, these GLP1 receptor agonists are just phenomenal with their

mechanisms of number one, you know, improving insulin production, but improving beta cell function in the pancreas, improving glucose absorption in the muscle, improving and decreasing muscle atrophy attributes that are there in the cell of the muscle. So basically they can stop, like they can decrease the effects of myostat and they can decrease the effects of these muscle ring finger proteins and these atrogen ones that are like their their atrophy type of of signaling agents that kind of grow as we get fat or as we get any kind of efficiencies we lose those things become more prominent and it's why you lose muscle. So what's amazing with these GLP ones is as you lose weight, you're not going to lose muscle mass.

And that's incredible. That's incredible. If you know how to use them appropriately and in efficient way. Do we have pretty good controlled studies where we compare somebody who is utilizing this peptide and then those that are not, and like what the muscle, how much muscle one loses versus the other? I mean, do you have, do we have research around that yet

to like really to, to substantiate that? Yeah, there's, there's massive research. Okay, so, there's massive research. Okay, so muscle mass is always like the last thing where if you don't have the dollars for the studies, right, and there's no end game for the pharmaceutical company, your studies are going to be limited. But, but, but, so all of the research in these peptides has been based, has, has significant data on cardiovascular improvements. All of the things that we know are relevant in something that can be very healthy for us. So, so let me just eliminate all those questions.

I mean kidney, liver, heart. Right now, right now, the your your question is great timing because now it's focused on muscle. And and the data is just coming out of, you know, where do you start with all the studies? They start in a single organism, then they go into mice, and then they go into humans. And so now we do. Yeah, we do have human data that shows preservation of muscle mass, and it's incredible. But we knew this. I mean, we knew this before, based on the mechanisms and the pathways because the pathways never lie. The pathways are always right. So we know if you're activating, for instance, it only makes sense that if you're improving insulin sensitivity, and that means you're improving what insulin does in protein synthesis by encouraging this BIP through K, AKT, the M-Tore pathway. You're gonna make muscle or you're

gonna keep muscle. It's just, you know, it goes to, as you guys are familiar, it goes to just the significance of the studies done on just stretching and how stretching can keep muscle mass because it releases the signaling agents that influence those atrogyry factors or stop myostatin. But to answer your question, yes, the studies are there now're they're progressing because of the importance of having a peptide that has such a significance in improving efficiency But maintaining you know with biggest problem we have and as you guys probably are really familiar with and what you do is As people are getting older

They want to the best thing you can do is maintain muscle mass. And because lots of muscle mass leads to disease, it leads to lots of bone, it leads to everything. And if we can improve that, we can save billions and billions of dollars in healthcare. And so it's getting there and it's getting better. And we've just got more amazing data now to integrate now that last phase of muscle and they've gone back to the brain now.

So, the research is going more now, again, on Alzheimer's and Parkinson's and early cognitive dysfunction issues like that. Interesting, because with blowing my mind right now is one of the biggest challenges with weight loss is the metabolic adaptation that tends to happen, right? So if you look at studies on cutting calories and increasing activity, unless strength training is involved, you tend to see muscle loss along with weight loss

because in the theory, is that the body is trying to match Energy intake, right? So what you're saying is through these GLP P1 agonists peptides It's helping the fat loss process but also maintaining your metabolism in other words It's it's keeping the muscle helping you body burn body fat just by improving its muscle helping you body burn body fat just by improving its energy utilization, which is this is remarkable. I've never heard it explain that way.

And you know, as a trainer, I trained people for two decades, one of the most challenging things. And this was it. Like, if I could get a person to lose body fat and either build muscle or keep muscle, like I was winning, like that was it right there. So something like this sounds like a total breakthrough. Is that how it's being received right now? Is this because I'm reading about it like crazy,

in particular, the one that I mentioned, some agglutide, is it making waves like we would, like I would predict, or like I would think? Well, I guess it depends on what you're asking. I mean, let me just, we could break down what you just said really quickly and just to say that, remember, when, with all of these weight loss type of diets, the most important thing you can do, that you have to do, is you've got to maintain protein intake. I mean, if you're not going to maintain protein intake, you're not going to make muscle, or it's going to be very difficult to maintain, because muscle mass, muscle needs protein.

It's not something muscle makes. You've got to put it in your body. A lot of these diets lead into acid-based problems and actually, again, low-grade metabolic issues that happen. And what happens with that? Well, the body has to compensate and maintain its pH. The way it does it is by taking amino acids from muscle, degrading it, to buffer the acid-, the, the, the, ask the slight acid change, basically the pH change. So that's why people lose muscle mass over time based on, that's why diet is so crucial. And I'm a huge proponent of protein, but, but protein, right? Protein that you get in meat or anything like that is basically an acid. So you have to offset those acids with your fruits and vegetables to make sure that you're

aligning that diet appropriately or you have to take things like sodium bicarb or you know like alpacillus or gold things like that to offset that acid-based balance. So a lot of times when you're in these problems with people with weight loss and losing muscle, you have to address these pH issues or you're not going to go far either. So when you go into these massive crazy diets, you change metabolism. You're changing things that are not potentially efficient for the patient. So you got to be very careful. You got to maintain diet. You've got to maintain protein so that they so that they can meet those those goals. There's something. Oh, so you said,

is this a craze? Well, it's turned out to be for fat loss, but it's done. In my opinion, it's nobody really understands. If you don't understand the mechanisms and why you're using it, and then how to count. So here's something else. This will be great for you guys. So as you focus more on this and you have clients with this that are utilizing it with their docs and so forth, the issue you're going to see with these GLP ones is, okay, they improve fat loss, they help maximize oxidation of fat, but they also work in the brain by reducing appetite. So you've got to consider this when you're approaching a patient and you're telling them,

well, we got to get more protein in you while we're working on maintaining muscle or even trying to build muscle and lose fat because what are you fighting? You're fighting that person doesn't want to eat. That person doesn't want that. So you've got to find what are those avenues then? How do I increase protein and make it easier for that patient? And I've always found that the easiest way to do that is not through these way in casing shakes because

what do those do? They fill you up, they make you, they make you not want to eat afterwards. It's really going to things like egg whites and things that are inexpensive, but you can get massive amount of protein and, you know, in a small amount of liquid or whatever form. So those are just ideas. I mean, I'm just telling you there are things that you gotta put together because you're gonna fight that part. You're gonna fight that appetite part. And so those people, even though the mechanisms say you can't lose muscle with GLP ones, well, I'm gonna tell you, you can if you're not maintaining your diet appropriately. That's such a, I'm so glad you brought that up because when I look back at all the clients

that I trained with fat loss and to South's point that would lose muscle, that is the greatest challenge. The number one thing I would see with all clients when I would assess their diet, the average American does not get enough protein and they definitely don't get enough protein to build substantial muscle. And then if you put that same person into a caloric, restricted diet, they even eat even less. So you're doing something that suppresses the appetite that is beneficial for fat loss.

But then if you're not eating adequate protein, we're still in the same predicament. So it's such a good point. And what's funny about this is somebody who really has trouble with cravings and appetite who really wants to lose weight They're listening to this one like hey, that doesn't sound like a bad side effect You know, it's gonna make me want to eat less, but it's important. I'm so glad you said what you said because you got to keep that protein intake high To you know kind of maximize the muscle preserving effects Well, and the things you guys are doing by instituting effects? Well, and the things you guys are doing by instituting resistance exercises needs to be done or else they're going to lose muscle. You got to have some exercise. If you're going to do a

GLP1, I tell all our patients, if you're going to do a GLP1, you're going to lose muscle unless you do some type of resistance exercise right to just help signal to maintain muscle mass. So, but you have to get that protein in the best you can. And so it's a battle, but it can be done. And you can get incredible body partitioning. I mean, incredible if you know how to use these things appropriately, and it's really, as you guys know, what works for one person doesn't work

for the other person the same way, it's why you have to tailor everything you do to your client, to your patient, and in breaking through plateaus and losing weight, right, and getting stronger, all those things. I really appreciate your balanced approach. Let's talk about, you had mentioned these kind of growth hormone releasing peptides or hormones like

Ipa Maryland, there's Tessa Maryland, as a CJC, 1295s, another one. How do these work and then what are their effects on the body with fat loss in particular? Okay, so you mentioned, so what we look at these as growth hormone releasing hormone or growth hormone releasing peptide, which means GHRHs are like what you refer to as Tessamorlin or CJC1295, which has been bastardized by the pharmacies and everything. CJC1295 really is not a real, it should be modified one, 29, but that doesn't matter.

Let's just, let me focus on a GHRH is something that's produced by the hypothalamus that stimulates the Antirapetuitary to start making growth hormone. It's a signal from the hypothalamus that signals the anterior pituitary But the anterior pituitary does not release growth hormone right away based on that signaling And actually the anterior pituitary, that's the Cretagog that's there that we want to produce growth hormone is inhibited by something called somatostatin, which is another peptide.

And that somatostatin increases as we age, it increases over stress, it increases with disease, and it starts limiting the amount of growth hormone that could be released. Well, the Ipa morl and that you brought up is a second, third generation GHRP growth hormone releasing peptide that is made typically their referenced after... There are things that are actually released from the stomach that I can get into later, but that mimicked that. And so if a morollon is something what its job is to influence the

Antirpetuitary by what does it do in inhib inhibit somatostatin, it also increases the release of more growth hormone releasing hormone from the hypothalamus to the pituitary. So it increases the the the the amount of growth hormone being made, but what it ensures is release of growth hormone within 20 to 30 minutes, which is really you want to control when you release it. So taking a GHRH by itself is not the most efficient way to do anything. If you're really trying to work with cell function and it gets into more detail, but that's why like Semmorland, Semmorland was one of the first GHR ages and it had good data and it

had poor data based but it was based on the fact that you couldn't control how it released growth hormone. Well with the addition of a GHRP like if moreland, you can control that release. So that release of that growth hormone will happen within 20 to 30 minutes. And there's all kinds of things that people, diet still influences. When you use these peptides, you have to be aware of after you, you know, when you utilize, let's say you're going to do it, you know, most optimal times are morning and night when you start with these one morning because it's a beginning of the day, beginning of the circadian clock, beginning of circadian rhythms, beginning of NAD production, which is all

about this NMADPT, an enzyme that is necessary to produce and make NAD production, which is all about this NMAPT, an enzyme that is necessary to produce and make NADs. So this is very important when you time these to make the most out of why growth hormone is important in circadian rhythms. So in that being said, the growth hormone release can be influenced by, let's say you did an injection or you took up an oral or whatever, most of them have to be injectable though, of the GHRH, GHRP like CJC and Epimorland together, well you got to make sure you don't have, you don't eat anything because if you eat some carbohydrates or fat, that will influence and blunt the response of what you just did. Pure proteins find, but other things like that, you can't do. So you have to understand the nutritional aspects

of what influences and how these work. And that's why you get people say, oh, this didn't do anything for me. I did get anything out of this. It's because they don't understand what they're doing or they take too much, they go over the saturation dosing of these things. So, it just gets, you know, there's a plethora of information you have to be aware of to really use these effectively. So when you use that, your second question was, how does it help with fat? Well, it's improving one of the main and incredible aspects of a growth hormone

release is its influence. And the fact that these also, these GHRHs and GHRPs have receptors that they work on the cell also to influence efficiencies, it improves basically that thing I talked about about how glucose is better utilized through aerobic respiration, meaning it goes all the way through like Holisys and through mitochondrial respiration. And so you end you're gonna use fat. So it influences that. And then just depending on the type of peptide you used to do that, which there are others,

type of peptide you use to do that, which there are others, you can be very effective in working on not just improving fat loss, but by you're improving these mechanisms called AMPK. AMPK is all about improving a topogy of a cell, clean the cell up, make things better. Then down the road, you get IGF1 production and that leads to muscle protein synthesis. So you get part of autophagy, cell cleaning, improved AMPK production and then you get the MTOR effects down the downstream of protein synthesis and so forth. So really fascinating stuff that makes such a difference in improving health and maintaining, giving people the ability to maintain their youth or maintain their ability to train. I'm 61 and I trained better than I did in my

20s, 30s, 40s or 50s and I haven't stopped yet and it's because of optimizing self-function, it's optimizing nutrition, it's optimizing sleep stress, and training, right? It's, which is all physics. You know, it all comes down to forced mass acceleration and all those issues, but you guys, that's what you do. It sounds like these peptides, by themselves already improve the cells function and have great benefits by themself added with good diet and training.

It just compounds if them understanding quickly no matter what just taking a lot of these peptides have their benefits by themself. But if added with a diet that's appropriate with them in addition to strength training, it sounds like that's where you see this like kind of mind blowing type of results from it. Yeah, so and that's that's a really good observation. And I'm sorry if I talk expansive and all of this, I really, I try to that's a really good message that I can send to you guys to let you know, like in my field of where I work with very severely ill and people, you know, post-COVID fatigue, all of these incredibly complicated autoimmune issues, metabolic issues, these peptides are

phenomenal because yes, they help with efficiencies, they help us get to where we can start improving problems that have occurred that may be structural or who knows what in the cell. But when you take the next step and start improving nutrition and then you're getting healthier and then I get them into an exercise program which is the end stage right because those people can't do that at the beginning. It's incredible how they all come together to maximize efficiencies of the cell. So your observation is absolutely correct and so in healthier people who are just looking to optimize, you know, training and that's where this all comes together.

You know nutrition and sleep is just as important though. And stress release, relief and exercise and the right type of exercise. You can't, if you're not going to do resistance training, I just tell people, why are you training? I mean, it's, you, you, cardiac's great, but you have to have resistance training because resistance training, this is where all the information is going to explode also about how we keep seeing all of these new myocytes and ex kinds that are being, which are peptides that are produced by muscle, by working on resistance type of training. And it only makes sense. It's just wonderful to see where this is all going and to see things like you guys are doing. I mean, these questions you're asking are awesome. This is what people should be,

should be, they should be seeking this out and looking to, for the, and knowing that there are answers out there to help them optimize their lives. You would really appreciate, uh, Sal wrote a book two years ago, and it's been almost three years now called the resistance training revolution. And you're, you're highlighting some of the points that he makes in the book. So I think you'd really enjoy that. Now, I'm going to ask you to do something. I know it's going to be challenging for you because I know I understand how your mind works within all these great peptides that are out there in your experience. If I asked you to give me the top three to five that you think seem to be the most beneficial for most people. And I know we all know here in this room that there's such

a wide individual variance. And you could say one's great, but then for that person, it's not the best. But generally speaking, when you look at, you know, all the patients that you've helped as a whole, what seemed to be like the big bangers. So your question is very similar to the questions I get from all my physicians I teach around the world. Okay. I feel better about it then. It's like I feel, you know, it's so funny. You get done after a two day seminar, you've worked your ass off, you just spit out all this information and then you get somebody raises their hands that this was wonderful

But can you tell me? You're giving your top three and you're just like what the fuck To make you feel good about it though That's I think that's kudos to how well and non-biased you are about explaining the information I could tell just by the way you communicate it, that you're very careful about all the nuances. And I think that when you probably do these, people are respect your opinion and they just purely want to hear, what is your opinion looking at the general pop?

What do you see are like your personal favorites that are helping people? Sure. Well, I appreciate the question. Thank you for the observation. I want to just say I'm respectfully humble of everything. I mean, I make all the mistakes everybody else makes. I just happen to have a little bit more knowledge on something than you guys know. You can do your work, you do your research.

You can be just as smart as anybody else. And I've just been fortunate that I've been doing this for 40 years and I just know a little bit more. So that separates me a bit more, but it's all about, right? You got to put the effort in, you got to do all these things to make things happen. And so coming back to that question, I'd say the top ones got to be BPC 157 and BPC 157 has just been, it's an incredible peptide based on and I'm going to tell you, you know, there's multiple pathways that BPC does not have a direct pathway.

It has all these indirect pathways and how it works. And it's a synthetic peptide that's actually mimics something that's made in the stomach. It's, I know we refer to it and say that it's directly made from the stomach, but it really isn't. It's something that synthesizes very similar to a peptide that's made by the gut. That's a repair type of peptide. But basically, what I love about BPC 157 is the versatility

of how many, because it's all about repair and restoration of tissue, that has to do with so much in disease states. If you think about bad microbiomes and you guys might think of it as, you know, I hate the term, but leaky gut or bad cell integration and leaky brain blood brain barriers and BPC plays such a role in in extracellular matrix function, which is a whole another topic, a huge topic actually in recovery, repair, and hypertrophy and muscle building. That's where if you want to focus on where the research is, it's extracellular matrix. And that's my big focus, is extracellular matrix of where you, all these signaling agents have to go from cell to cell and outside and they follow these actin, myosin,

to go from cell to cell and outside and they follow these active myosin, these filaments and it's how cells rebuild. They got to follow all these little filaments, these pathways. And BPC has an incredible effect on improving extracellular matrix. And that's a big thing that goes bad in everybody, in pH problems and as you age, it's all about extracellular majors. So, and BPC increases growth hormone receptors on the cells, so it influences those other things we've talked about to be better, improves nitric oxide production. It has, it has multitudes of pathways of how it works. And it's, so you've got, it's

a, it's a multi-modality peptide that I just love with. I have used it for, oh my gosh, since it was first, well, let's say this, I've used it for a very long time and I've never seen a side effect with BPC 157. That's a pretty incredible statement to say about a peptide and not see a side effect. And I just think it's got so much, it's just got so many good things. And the most incredible thing about this peptide, and I've had great discussions with the gentleman who actually synthesized this peptide in Croatia. He has the patent on it and developed it.

And great, we've shared a lot of science together, but this peptide has basically minimal clinical evidence behind it's all based on animal studies and we have very few clinical studies, but we have a few now, we have some that are active, but you'd think we'd have a lot more on this peptide and its versatility and how it's used in different disease states. Again, that has to come down to money and work in these companies make their money and they can't make it with BPC 157 because it's out there. So that's it. So BPC 157, I like a lot. I like selling, which is an nasal. It can be introduced as a nasal. The BBC 157 is typically injectable, but can be PO. And that's a whole nother discussion about that. But the, I like selling because of its influence on brain-derived neurotropic

factor and how it just works on, you know, seems to be anxiety as one of the biggest problems that we're seeing a lot of in disease states and in just life. And selling has really a nice place in working on efficiencies, not just the body, but specifically in the brain to improve this brain-der neurotropic factor, which has a tremendous influence on cell neuroplasticity in the brain and cognitive executive function, and just dealing with the world basically in a way that's manageable for everyone. So I love that.

I love selling. I love its immune properties. It's got immune modulation properties, which are tremendous. So I would say that, and then I would say probably the GHRHs and GHRPs are just, they you're 30 and then as life progresses, you're producing less alpha-ketogluirate, you're producing less NAD, you're mitochondrial functions declining, you're producing, you're utilizing less fat oxidation, you're increasing glucose tolerance, you're increasing insulin resistance. Is there anything out there that can work on so many levels in influencing the progression of something I've just called

aging, which is the number one, you know, it's the number one influencer of any disease, right? The older you get, the more likely you are to have any of these diseases, glaucoma, sarcopenia, diabetes, heart disease, brain disease, you know, anything you want to say. Well, these GHRHs and GHRPs are just, I think, are phenomenal in how you can alter that course of life and efficiencies of the cell. And then, and so that's four, you want five. I would say five, I'd have to say probably Fymalan. It'd be either Fymalan or Epitalan. Fymalan is just an incredible immune modulator.

And it's, you know, what is weight training, what is adaption, what is, what is it all about with muscle rebuilding and regeneration? It's all about the immune system. If the immune system's not functioning, if that macrophage isn't there, as there's muscle regeneration or muscle hypertrophy and their phase changes in the macrophage isn't there, as there's muscle regeneration or muscle hypertrophy, and their phase changes in the macrophage that have to occur, and in the fibrocyte, and in the satellite cell above the sarcolemic, if you don't have these things functioning right, I don't care, you're not rebuilding shit. And again, it all comes down to efficiencies of how those cells work,

it all comes down to efficiencies of how those cells work. And these GOP ones, I'm sorry, these are these fymilins and how they help with immune, keeping an immune cell in the proper phase when it needs to be. Remember what I said, how a cell is naturally intelligent. It just wants the signaling agents to help it make the decision when it needs to. Perfect example. People talk about, well, we got a immune boost. Well, that's total bullshit. Nobody can. You boost the immune system and you're going to screw

up your immune system. It's about immune modulation. It's about keeping it in sync, right? And that's thymalan allows through many different pathways that activation of these immune cells to communicate appropriately. So I'd say thymalan is probably that would be, what, how many do I give you? That's five, five, five. five right there. You did it. You did it. Perfect. Dr. Sees, I really appreciate your balanced approach and how you communicate.

And this really reminds me of why it's so important that people go through a doctor when they're using peptides. Because I know you can go online, you can find peptides through kind of some gray market or kind of area, but I mean, these have real effects on the body and I just want to stress, you probably, you definitely want to work with a doctor who knows what they're doing when you're using these substances and I'm sure you would agree. Well, my gosh. Yeah, it's all of online. It's total bullshit. I mean, you have no idea.

They haven't been third party tested. You don't know, have they been tested for infection? You know, have they followed all the standards of what we, why you spend this money for something? Absolutely not. And I've had, I mean, I've, gosh, I used to present the data of where I test those online products and show the docs. This is what you're giving your patient. Are you crazy? Because none of them had, maybe if they did, they had 50, 60% of what they were really supposed to. But so let's think about this. Here's the best way to think about this. A peptide has to be 99.8%, or 99.6%, which is the low point of what it says it is.

It has to be that full peptide. Because when you take this peptide, what happens is it gets hydrolyzed. The peptide itself, to some degree, it stays intact or it breaks up into its biological components. Well, if you have a peptide that's not pure, you have fragments that are breaking off that are peptides that you have no idea what they're doing. They can be hepatotoxic, they can be cancers, they can be anything. And I've shown that in, in, in, in looking through a specific testing where you can look at the levels of what's, what's in this hepatitis, it's, it's insane and

it's dangerous. And that's why you've got to be really smart. Wow, you just said something that's so important in regards to that. You know, like it's very popular for people to go online and buy testosterone on the black market. And probably the biggest risk there, aside from some of the really ridiculous things, it's just probably getting it watered down.

But you could give somebody who's claiming it's 250 milligrams testosterone, 125 milligrams testosterone, and they'll still feel it and they'll still have some positive effects. But what you're saying, if this thing isn't 99.6% of what it says it is, it's not only probably not working, but the adverse effects. Yeah.

You have no idea, I could have all kinds of weird stuff. You just can't water this shit down and sell it. It doesn't work the same way. Well, here, it's kind of like what you said, but here's the bigger problem is having 50% of that peptide in there and works and the people feel it and they say, oh, it's working. But it's that other 50% that's

doing, you have no, you have no idea what it's doing to your DNA, what it's doing to, to create more what we call cell synesis, which is what's happening. You're causing premature aging. You're doing things that you have no idea are going to screw you up for the rest of your life that we're going to have a very difficult problem fixing down the road if you stay consistent with that type of care. But the bigger things are what we see with like hepatotoxicity and what happens. They're horrible. It's horrible to see these things that occur.

Well, appreciate you coming on the show, Dr. Seed. This was awesome. Yeah. Thank you coming on the show, Dr. Seeds. This was awesome. Yeah, thank you. Super enlightening, thanks. I have, actually I have a blast talking to you guys. I like you guys are, I'm gonna have to check you out. I'm sure you guys do some, you had all the right questions. I love talking about things that you,

I could tell all of you have a passion for what you do. That's awesome. We also have something in common. You actually opened up this conversation with your priorities and ours the same way. So we're all fathers and we talk about fatherhood number one first for us and then all the other stuff falls into order. So we have that in common too. We're definitely going to try and have you back.

We're in line with it. Yeah, we're going to fly you out next time. So I hope you have the time. Get you out in California here, come in the studio. Yeah. This has been great. Well, let me finish with this one thing. You guys will love this then.

So all my kids, like, when my kids want to come find me, when we want to have a family discussion, it's the garage is our weight room. And so my kids learn very young, you know, proper technique, all the right things, but they learned that life was handled in the weight room. I love that. I love that. That's awesome.

Thanks again, Dr. C. You're welcome. Thank you. It was great meeting you. All right. Nice to meet all you guys. Be good. Thank you too.

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