Mind Pump: Raw Fitness Truth - 2110: Ozempic the Miracle Fat Loss Peptide: The Truth With Dr. William Seeds

Episode Date: July 3, 2023

Dr. Seeds LIFTS! (2:15) Misusing the concepts to make assumptions that aren’t true. (5:05) Semaglutide/GLP-1 Agonist: How do they work? What were they developed for and what are they being used for now? (7:02) Could GLP-1 agonists be anti-addiction drugs? (18:12) Setting someone free through self-belief and behavior change. (29:53) The optimal timeline for results. (33:32) When one pathway is dominated, all the other pathways are neglected. (37:52) Can using too much of these GLP-1 agonists oversaturate your receptors? (40:56) Is there a type of person this isn’t for? (44:25) The politics behind Big Pharma. (45:57) GLP-1 agonist, a miracle substance? (51:47) Why you should go through a doctor. (53:31) How and where to start if you are interested in this peptide. (56:27) Related Links/Products Mentioned TRANSCEND your goals! Telehealth Provider • Physician Directed GET YOUR PERSONALIZED TREATMENT PLAN!  Hormone Replacement Therapy, Cognitive Function, Sleep & Fatigue, Athletic Performance and MORE. Their online process and medical experts make it simple to find out what’s right for you. Visit Seed for an exclusive offer for Mind Pump listeners! **Promo code MINDPUMP at checkout for 30% off your first month’s supply of Seed’s DS-01® Daily Synbiotic** July Promotion: MAPS Starter | MAPS Starter Bundle 50% off! **Code JULY50 at checkout** What is Ozempic Face? Doctors Explain - TODAY Addressing Commonly Believed Myths About Semaglutide The Discovery of Insulin: An Important Milestone in the History of Medicine Could Ozempic Also Be an Anti-addiction Drug? - The Atlantic GLP-1: Molecular mechanisms and outcomes of a complex signaling system Mind Pump Podcast – YouTube Mind Pump Free Resources Featured Guest Dr. William Seeds (@williamseedsmd) Instagram Dr. William Seeds | Seeds.md  

If you want to pump your body and expand your mind, there's only one place to go. MIND, MIND, MIND, MIND, MIND, MIND, with your hosts. Salda Stefano, Adam Schaefer, and Justin Andrews. You just found the world's number one fitness, health, and entertainment podcast. This is Mind Pump. Alright, so you're probably hearing a lot about this new wonder drug. It's a peptide called OZEMPIC, the generic name being semaglutide. Supposedly people are using it

and without doing anything else, without trying anything else, they're just losing lots of body fat. I mean, this stuff is exploding, it's going mainstream. This was a diabetes medication, but now people are using it for weight loss. They're touting it as a miracle weight loss drug.

Well, we had an expert on the show, Dr. William Seeds, he's actually the leading expert on this subject, he's talks about this, he's been talking about this for years and years and years, and he came on the show to talk all about some agglutide, otherwise known as ozemic, and these other what are called GLP1 agonist type medications, and believe it or not,

now I'm very skeptical of this kind of stuff, but he blew my mind. It's actually a lot better than you're hearing no joke. You can hear all about it in this episode. It's really crazy stuff. Now, if you're interested in using peptides, work with a doctor, get some blood work done, work with a doctor.

So we work with some partners at mphormones.com. They work with GLP1 agonists like some partners at MPHormones.com. They work with GLP1 agonist, like Semiclutide and other peptides. So go to MPHormones.com, talk to an expert, and if you qualify, it works out, you get it from a real pharmacy. Now, this episode is brought to you by a sponsor, Seed. This is the world's best probiotic for inflammation and for gut health. Go check them out. Go to Seed.com-flour-slash-mind pump, use the code Mind Pump for 30% off your first month's order. We're also running a sale this month

on some workout programs. Maps starter, the beginner workout program is half off, and then we have a Maps starter bundle that includes Maps and Obolic and Maps Prime, the best combination for muscle building and metabolism boosting and strength is also 50% off. So if you're interested in any of those workout programs and you want that discount, go to mapsfitinistproducts.com

and then use the code July 50 for that discount. All right, here comes the show. Dr. Seeds, welcome back to the show. Thank you. It's great to be here. Yeah, we got you in person this time. You, do you work out? You guys bustin' out of the shirt.

This guy definitely lifts. How long you been training for? Oh boy, since I got my first Sears weight set in Sears in third grade. Oh, classic ones with the cement set. Classic ones with the bench and everything and I remember my, it was my big Christmas gift that I wanted and because I used to see this thing on these bubble gum wrappers where you could get a wait set. I didn't know you could get it.

My father got me a Sears wait set and I had no idea how to use it. He didn't. And I just started there. Wow, that's awesome. That's true. There's a whole generation listening right now that have no idea what Sears is. Yeah.

Yeah, there's a catalog. He's to buy them online. So this was back in the... Was it Jack Lillian who was promoting that back in the day? No, just Sears, I think. Just Sears, like, thought he needs structure. We got everything. Yeah.

You had a catalog that was this big, and if you needed something, you got it from Sears. And it was amazing when I still remember it, coming downstairs and seeing what Santa brought me and it was just, it was awesome. Sears was like the Costco of today. Yes, like any idea why they went under, you know Doug? I think because Costco and Amazon, you just put a competition. They couldn't compete with even if they had their foothold.

I know, you used to buy tools there. Everything. You get your hair cut, I think even tires rotating. Yeah. And head tremors. That's actually where you guys bring in back crazy memories. That's where I first learned that I needed a spotter because I had a lot of it. I thought it looked so great and I took thing off and I got trapped. And yeah, it was bad.

We've all done. Yeah, I had to learn that. The shimmy or the roll under here. So this was in the 70s. This would have been in the late 60s. Wow, that's great. So let's see, at the time, you're looking at like Muscle Builder magazine.

This is Larry Scott and then Arnold later and all those, were you following any of those guys? No, I mean, I was a little kid. We didn't have any of those things. All I knew is I wanted on the gum, there was this guy called Bazooka Joe or something who he wanted to be strong. And I'm like, gosh, he can do all this.

I want to be like that. And that's awesome. And pi pi. Yeah, if you guys remember pi pi, eight is spinach. Oh, of course. And he gets strong. I have course, you can't even, that's why eight spinach.

I hated it. That's why I had to eat spinach, but it never seemed to work. And they say these ads and stuff, don't influence kids. Totally, totally. Totally. So, totally. Totally. So this is great because you have a unique perspective.

So why we like you on the show is that you obviously are an expert in your field, but you also are very experienced when it comes to fitness and training and strength training. And sometimes there's a bit of a divide, right? Like we'll talk to a scientist or a doctor and you could tell that they don't have any personal experience or they haven't really worked with anybody. That communication isn't there. Yeah, in that space.

And the reason why this is important, and I'd love just some commentary on this before we get to the main topic, is that people who are very consistent with exercise, people are trying to build muscle and eat in a way to do so and all that stuff It doesn't it's it's a bit of a different category like to give you an example We look at things that may drive let's say cancer and so they'll say things like we need to avoid You know stimulating you know stimulating, you know, repomise and, you know, mammalial, repomise and whatever the chemical is because it could cause cancer growth.

But that also builds muscle. M-tore. M-tore, thank you very much. M-tore, mammalian target, repomise and, but that also builds muscle, right? Or they'll say something like a really low protein diet can cause, you know, improvements in longevity with animals. Well, and it gets if you're sedentary, don't do anything maybe, but with athletes, I don't think that's the case at all.

So you got both, which puts you in a pretty cool category. Absolutely, I love what you just said, because there's so much truth to that, and there's so many people that go the wrong way. And they're even my peers, you know, and people who are just focused in one vertical area and know a lot, sometimes miss, you know, miss, miss use the concepts to make assumptions that really aren't true. And you just, you hit it on the head with that. Excellent. Yeah. So that brings us to

so peptides and peptide science has been around for a little while, starting to become much more mainstream, especially right now, and you could probably place the notoriety or the, I guess the awareness squarely on the GLP1 agonist class of peptides or ozemicic, the brand name of somnoglutide. It's like everywhere now.

It's exploding. And what we just talked about, I think, is a great place to start because let's start with some of the articles that, because everybody now knows, oh, they cause weight loss. I think that's accepted now. It's all over the media. But then we have articles saying, oh, it caused just as much muscle loss. Or you see these terms like ozemic face, you know, we're you know, I read an article on that where people skin looks to be sagging or whatever This this muscle loss really is not this is something you want to look at if you're a sedative don't change your diet

Just go on it versus someone who does is that would that be I be, I guess, accurate? Correct. Okay. So let's talk about some of Glutite and GLP1 agonists. How do they work? What were they developed for? And then let's get into what they're being used for now. Sure. So the GLP1s have been around for actually quite a long time. And I started lecturing to our physicians

around the world here, probably about eight, 10 years ago, where GLP ones just started to really make their push into more on the side of what we know about right now as far as type 2 diabetes. But GLP1s have been around for the study, they started in the study of neurodegenerative disease. That's where the peptide was recognized to have considerable effects because they're GLP1 receptors in certain cells

in the brain, microglial cells, astrocytes, so forth, that have an influence on controlling inflammation and they were looking at this avenue of the potential of GLP1s in neurodegenerative or early cognitive dysfunction, Alzheimer's, things like that. Now why did they start there?

Was it the inflammation? Just the geologists, scientists, at the time had some, had the specific receptors that they were looking at that they felt could influence this immune cell in the brain that has a great influence. A microglial cell has a great influence on basically inflammation in the brain. And it's like the master house cleaner of the brain. It keeps things kind of intact, but it can also change. It can do something called a polarization of into a bad cell that can start producing a lot of pro-inflammatory

things that actually start setting off problems in the brain. So they saw that or they show that GLP1s could influence that inflammatory state of the cell and convert it back into an anti-inflammatory type of cell versus a pro-inflammatory cell, which was incredible. And so they started studying this more in trials and they started seeing other incredible changes that they kind of, we kind of knew about anyways because GLP ones are made, we make them in our stomach and we produce these are natural peptides

that we make that have an influence on increasing insulin and improving glucose absorption and you know making making the they're basically it's something that you secrete once you put something in your mouth and you start eating it's it's something normal it's an increase and it's you produce it to help you digest and utilize glucose. I see okay. So anyways they because of those, that aspect also, they started seeing, wow, these people that were doing these trials and they're losing weight. And their glucose sensitivities better,

their insulin's better, it's like, oh my gosh. And so Big Pharma said, are you kidding me? This big business in diabetes, why are we going this route? And so a big shift started progressing more into diabetes and which was incredible and which was needed because it actually, it's a peptide that actually makes changes that are so significant.

And this is why I get so frustrated when you've got, you've got all these people out in this world who have a little bit of knowledge that are talking about things that are, like what you just said, they're misusing concepts to make something not look good. Here you've got a peptide that is actually something that, finally, you know, the first big thing that came along for diabetes was insulin.

That was a peptide. People don't know that's a peptide. That was one of the first peptides ever developed. Got the Nobel Peace Prize. Did all these amazing things. Insulin changed the world. And now we have these GLP ones that have an even greater influence because because what they do is they actually change not just improving glucose, not just improving insulin sensitivity, not just improving efficiencies of the cell like AMPK and all of these things that improve mitochondrial biogenesis and improve fat cell function and muscle cell function and prove you know you name it These cells actually are these peptides. What do they do? They change phenotype phenotype

phenotype now for people don't know phenotype. Phenotype, now for people who don't know, phenotype just means a cell has a genetic code, it has genes that tell it what to do and it makes, let's say a cell makes a certain protein, right? That genetic code is there to make that protein. Well, if something goes wrong in the cell where it can't make that protein right, that's a phenotypical change, meaning, you know, there's radiation or there's something wrong with the cell that causes that the genome's still the same, but it just doesn't make that protein right.

So that's a phenotypical change. Well, that's what happens with diabetes. You get a phenotypical change in a cell, phenotypes change. And just by giving insulin, you can make them better and they can live, but you don't change the phenotype. But GLP ones change the phenotype. This is more than room. This is, this goes beyond, yeah, this is the root cause. This is where peptides, this is where when we started lecturing on all of these peptides years and years ago, the key to success in medicine

and the future of the world is get to the root of these problems and actually don't treat things symptomatically, which is, you know, hey, we're doing great, but let's, can we do better? And so, G.L.P.1's change phenotype. That's, guys, I can't, I can't tell you how excited I get every time I get to say that. Have you heard that yet? As I said, I've not heard that. Nobody's ever said anything like that. No, okay, so that right away, what comes up for me is the potential politics involved in something that. No, okay, so that right away, what comes up for me is the potential politics involved in something that actually solves the problem, because sometimes, and this is the pessimistic attitude

I have towards Western medicine is, sometimes I feel like our goal isn't to solve, it's to just continue to treat, so your return customer, are we seeing some of this political battle between this because it is that incredible? Like from what you're saying, it almost seems like we would stop using insulin and go straight here only, or is there still gonna be a case for insulin?

There's always gonna be a case for insulin, for, you know, we're talking about, this is the tip of the iceberg, really, this GLP ones, because these GLP ones, we continue to modify them. How do I say? So I travel all over the world and I get to speak with all the guys that are on the cutting edge of doing all of the greatest research on all of these type of molecules.

For instance, the GLP ones are, they're being upgraded every year. Something is different. Like, you know, we went from some agglutide, a GLP one to terazepa tide, which is a GLP one and a GIP. It's a glucagon inhibiting peptide and a, Oh wow. And a, yeah, and a glucagon-like peptide.

So it's a combination of two peptides. Well, there's another one coming that has three in it. And so what I'm trying to tell you is that, you know, disease and issues like diabetes, even type two diabetes type one, it's very stratified. There's many different aspects of how Complex it is for one person versus another, but But that being said these GLP ones are the first step into where we're actually we can change phenotype and

And I will tell you I will tell you even more so That I think it's it's just's not just that, it's the cool, from my perspective, the most amazing thing I've been able to see with this over the last you know, eight, ten years is how this one peptide has been the most successful peptide I've ever worked with in changing the mindset of a patient in in every aspect of their life. It's incredible. And and I'll add this at the end if you want. I had I just got back from Singapore where I met with the one of the leading scientists in the world who just figured out something that we were seeing clinically, and I'll save that for the end if you ask me if I remember, will blow your

minds away. And she's actually coming out to talk at my peptide world congress later this August. But the research just keeps getting incredible on the benefits of some things that have to do with one peptide, right? It's like, are you kidding me? So let me, okay. I can go a thousand ways on this. This makes me want to ask this, I read an article and I thought, wow, this is really fascinating. This is very interesting. This is all speculation.

I think it's anecdotes at this point. And I don't think there's any research to support this. And I wonder if this is what you're alluding to. They talked about how people going on GLP1 agonists lost weight, but also found that it reduced their cravings for other bad habits, like biting their nails or smoking cigarettes. Is that what you're alluding to?

Absolutely. Okay. What's the speculation behind that? Because obviously there's more than just, it's improving insulin sensitivity or whatever, in this particular regard, it's influencing behaviors in the brain. Is it that, when we're,

I wanna take a guess, is it that because we're reducing inflammation in the brain. Is it that when we're, I want to take a guess, is it that because we're reducing inflammation the brain, the inflammation itself is what's triggering people wanting to, to, you know, maybe medicate themselves with different habits or whatever. 100%. Okay. You're on it. Okay. So that's what they think, huh?

Well, it's not what they think. It's true. So what happens is, what happens in the brain, it's actually in the hypothalamus, and the science is, I mean, we spent three days, three days in Singapore on the hypothalamus, and all of these incredible pathways that have to do with,

say it eating and anorexia and gratification and all of these things are all interrelated in the hypothalamus. And, and, and it all comes down to, this is, you're going to love this. It all comes down to a hyper activated state of, um, tour in POMC, which is pre-opioid melacortin protein that's a precursor for, that makes a lot of these signaling agents in the hypothalamus that do all the things you wanted to do to stop eating or to eat. They're different mechanisms and I won't go through people call your show and say never have me on this again because I say too much. So, but it comes down to this state of emtore in the specific area of the hypothalamus and the,

and nobody, that's just, that's just like, it's just being written right now, by the way, about this emtore. And this is, it has to do with the lapidine receptors and so forth there also, but it's all because of emtore and how GLP1s can improve a balance and how GLP ones can improve a balance in AMP-K and M-Tore, and decrease that state of M-Tore, which is kind of, you know,

it's for your audience, in my world, in the cell, AMP-K is like catabolic, M-Tore is anabolic. You gotta keep them really even. And because if one goes a little off-kilter, it starts doing too much. So if you get like, you talked about cancer, too much m-tore. Well, too much m-tore, yeah, it's more proliferation, more growth, more bad things. And if you don't have enough AMPK, which is catabolic, where you break down things

to regenerate, to rebuild, you got to have them even. Does that make sense? It does. And so my, my, and that comes down to even something more biochemistry and so forth talk in something called redox, which is about NAD and NADH. And that's my world. I'm always trying to just balance those things. Okay. And that's what you're doing with exercises, what you're doing with diet, it all comes down to that.

So in the brain, and this is where, now you're going to, I'm going to have to spill the beans. This researcher in who is just so brilliant, and I couldn't, I was like a kid in a candy shop talking to her About this she's just presenting this hasn't even written this yet and she's telling me about how when The GLP ones Have had their effect over time on correcting some of these Let's say these circuits in the brain. Mm-hmm. What's incredible? Okay, so let's just back up and just when people are on GLP ones

What some of the first things it does is helping people is decreasing their appetite right everybody says oh I have less of an appetite now. I'm not gonna eat. I'm not gonna do this because something's been turned off or they get full faster, right? and They even start noticing hush. I don't think I'm gonna drink that alcohol like a I'm gonna have that beer I'm not gonna. Oh, I don't think I'm gonna smoke that cigarette or I don't think I'm you know things that would I think I'm gonna smoke that cigarette or I don't think I'm, you know, things that would gratify them in different ways. They're not seeking that. And it's kind of a shock right away

of stopping that system, turning that system off a little bit. Well, when here's the big argument about GLP1, it's just like, well, you're gonna stop this GLP1 after a certain amount of time and they're gonna gain all their weight back. Complete bullshit. Really? Complete. Well, if you're not doing your job, this is my, I'm a little outspoken about some things and I'm going to be outspoken here. If you don't understand how to use these as a physician, you shouldn't be using them.

And you've got to understand that this is an opportunity, like all opportunities when you're trying to work on weight loss with anyone, what are you trying to really do? You're trying to get them into that better mindset or nutrition and this. Of course, weight, resistance training, aerobic training, all of those things that mean way more than what you're doing with this GLP one, right?

This is where your fitness experience really helps. Well, it's, you guys know, it's the key to life. It's like, if you start looking at every paper in the world, you know, anxiety, depression, cancer, all these things, they're all based off of what? Research on exercise and that. Well, this, getting back to the GLP1, what you have to understand is this is just, Yeah. And that, well, this, getting back to the GLP1,

what you have to understand is this is just, it's a way to get some of these things working, right? Change phenotype, get them in that mindset of, okay, well, we're working on this weight now. So what else are we gonna do? We're gonna start talking about diet. We have to institute some kind of exercise program, right? Because we know, you know, any even have to institute some kind of exercise program, right? Because we know, you know, any even stretching Pilates, any of that stuff will turn off myostat and turn off

things that where people will start losing muscle. So, you've got ways that you can, because any kind of weight loss program, I don't care what it is, people are gonna lose muscle if they're not approaching it right. Doesn't matter if it's, if it's calorie deprivation or you're body is trying to reach metabolic balance. Yeah, it's just simple, straightforward evolution. Evolution, it's an adaptation. So what people say, well, a GP alone, or GLP ones, you're going to lose muscle. Well, yeah, you're going to lose muscle on any diet if you don't approach it correctly.

So just resistance training will turn off those things, but guess what? GLP ones actually have work on specific, they work on the atrophy gene, they work on specific genes in muscle to retain muscle, to retain muscle, that's proven. Also bone density. Do you know that? They work on osteoblast to retain muscle. That's proven. Also bone density. Do you know that they work on osteoblast to keep bone? Do you hear people talking about this? Hell no, because they're

not. They're out there just promoting themselves because they can just follow a tagline. But, I'm sorry, I'm sorry. No, no, go, go, go. Yeah. The emphasis I'm trying to create here is, it's not, it's everybody wants that one magic thing. Well, yeah, this starts the process, has these amazing things, but you've got to get other things going and with the diet stuff, you know, obviously we've talked about this, the protein, you have to increase the protein

to compensate because people aren't going to want to eat, right, at the beginning. So you have all these mechanisms that you can stop that. And in fact, you can, hello, you can build muscle on GLP ones and you can build incredible lean mass on GLP ones. But going back to this brain thing now, the coolest thing, it's just so, I get excited just thinking about it right now talking to

you about this. When you start, when you, when people start getting adjusted to the GLP ones, they're thinking that, oh, oh, Doc, this isn't working as well. After they've lost 20, 30 pounds, right? I'm, I'm, do I need to take more? And it's like, no, you're ready. You know, we've been working. We've been waiting for this moment to start talking now about, I'm, do I need to take more? And it's like, no, you're ready. You know, we've been working. We've been waiting for this moment

to start talking now about, I'm gonna give you some, I mean, I don't tell people this right off the bat, but I guess I am now more and more and now that I know this is true, is that guess what you've done? You've rewired your brain now to where, yes, you're gonna get hungry again. Yes, you're gonna have get hungry again. Yes, you're going to have cravings like you did before. But you know what the change is now? Guess what the change is?

Well, you've seen the path to the good side now by resisting and not doing it. Or you've had time to develop a different relationship. It's behavioral change. It's behavioral and you're all right, but it's you can guess what you can do. You can make the decision. Yeah. You can you have that claim, but you go, you can guess what you can do. You can make the decision. Yeah. You can, you have that claim, but you go, you know what, I'm not gonna do that today.

That is unbelievable. It's like, it's, and it's, I used to, so I was always getting this feedback with my patients, then, you know, I was struggling over time, like, thinking, gosh, don't need to increase this, or, and then I'd be, we just kind of work through it, work through it, and then I started, again,

hello, I'm a doctor, I got to listen to my patients, right? I learn everything from my patients. And don't think anything I say here is because I'm smart. It's, because I listen. And my patients started teaching me that they could make those decisions, and I'm like, holy shit, this is really doing that. This is the things we thought it could do. It's doing it.

So I met the damn doctor presenting the scientist presenting this in Singapore. I was, my team was flipping out because they saw me like, oh my god, Doc's gonna lose it. And I'm just, I was just, and I was telling her about, what we're doing clinically and she was just, she was excited and so it's, so what's happened is there's a real rewiring that happens and people can make decisions.

And now, can it go bad again? The answer is of course it can go bad. If you continue with the bad habits, it really will. It will tear it backwards. Yeah, if you continue, that's how you got there. You got there because it got inflamed, right? Right. So I don't know.

I don't know. Should you, would you mind pulling your mic just a little closer like a torture this way? There you go. Did that answer that? It did. So, okay, so I have a couple. You guys just heard some stuff that I was saving for my PWC.

You blew my mind and I have a couple like two thoughts will come in my mind. Yeah. So one is just to back you up. There's there and this is pretty established. There seems to be a commonality or a route behind all, I don't know, for lack of a better term, impulsive or addictive type behaviors. Right. So if you take somebody who's an alcoholic and let's say you just eliminate, for whatever reason, they have no access to alcohol. You see, very high occurrence of other addictive type behaviors.

When I was a trainer, I would see this with people who got gastric bypass. They all of a sudden couldn't eat a lot, but you'd see their rate of things like other types of addictive type behaviors. In fact, they'd have to go through counseling to talk about this kind of stuff. So the root is in the brain. There seems to be some kind of patterning. And so what you're saying is these GLP1 agonists seem to stop that. And then here's the other part, continuing down that path. Now I'm no longer engaging in that behavior.

I'm not reinforcing those pathways because when you create an addictive behavior, this is the crazy thing. When someone's doing something over and over that's harming them and you're on the outside, you always say to yourself, why don't they know that hurting themselves? They do.

It just has become this kind of repetitive behavior, this wiring. And so what you're saying is they stop it long enough, almost like training wheels, just to get them off that patterning, maybe create some other patterns, and they come off, now they've got a little bit of room in space.

And that's what you're noticing. That's very well said. And you said that better so people can understand it better than probably what I said. And at the same time, you're fixing those cells in a way that they're not going to follow those patterns again. They're going to function efficiently now. Those cells that were in this hypothalamus, this specific area, they were giving misinformation because of being in that M-tore state. They were just doing too much. Now, you have control of that. And what's even more interesting is I can go further and tell you how these people,

how their lives change. I mean, they develop different hobbies. They, they, they, they, they don't even know why they have. They, they, they can, they're, their ability to follow, their tasks to just carry out action. They, they can do it. It's that, it's like there's no, that procrastination or those things that used to be part of their lives before,

not around as it, it's there, but they can push through it. It's really amazing when you think about that type of an influence on, it's like you've set this person free. And it's just, and once the privilege I have is getting to speak with these people as this is happening and learning what's changing. And as you inform them about what's really happening, because I'm a big believer in teaching the patients as much as they can understand to learn what's happening

to them because some more information they have, the more empowering they have it, right? It's unbelievable how you just see this, like their eyes, their face, they just light up and then they start to go down these paths like, oh my God, this is why this is happening. Oh my god. And so I get to hear all of that. It's just it's incredible. Now what is like, so what is the typical timeline look like in terms of treatment? And so you start somebody on this and it's crazy. I mean, this is all mind blowing to me because

I was just thinking it was the fact that it brought back like satiety. And it was like a thing where it was like, you know, it was helped kind of taper off a lot of the cravings, but the inflammation part is really, really fascinating, but taking them through, you know, months and then kind of like getting feedback throughout the whole way. Like, what does that look like in terms of like starting this protocol? So that's another great question about an emphasis as how everybody is on a different pathway. And I would say it's usually that from what I could tell you in my experience,

that's something that's like what I'm talking about is about three months to six months down the road in their journey of trying to get to that point. But I'll tell you what's interesting is they showed these changes in the study that they did specifically looking at the brain. they showed these changes occurred instantly. Like things happen very quickly, like within days. So just by turning off some incredible machinery that's gone awry, that's gone bad, the brain can compensate very quickly.

But I think, I think it comes, so even though we know those things can change like that very quickly, I think it all comes back to what you were talking about in behavior and patterns and it just takes time for the person to kind of realize, oh my gosh, I can make these changes myself. Now, what would look like the best case scenario of somebody going through this with their physician,

but also then in combination with a therapist or a personal trainer or somebody to guide them through the best steps with this? So most of the people coming into this aren't focused on exercise or diet or any of those things yet. I'd say a lot of them. They know they got to get better. They know that things have gone bad and they're just grasping for something to help them.

They've done everything in the world and everything's not worked. That being said, with that being the more the type of people you see, it takes me, with those people, it takes me two or three months before I even can get them into the mindset of diet and exercise. Because they have to go, they have to get through, they have to first see the changes, right? They have to believe in your doctor, you have to believe in the process.

And just by the weight loss, it's incredible, right? And I always tell people, the weight loss, my God. The weight loss is a, that's a side effect. It's a secondary thing. The reason I did this with you is because I'm changing your body chemistry. I'm really doing things to help you bone, muscle, brain, everything. So when they get into that state, they want to start. I think I talked to you guys about this.

They want to start learning more. They're the ones who initiate. It's like, well, what's next? It's not me saying, oh, you got to do this program. You got to do this program because this is where it works. I you got to hear it from them And I'm gonna say most of them are totally on On point like okay, what what do I do now and then when they're making those decisions to jump in to exercise and Diet it's all over right That's the kind of person you get.

This is how we teach clients. Absorbings, we talk about that with. Meet them where they're up. Yeah, we're trainers with other trainers that you can't just get a client and then do this, do this, do that. If you're really good at your craft, you lead them to ask those questions from you

because when they come with that type of a mindset, they're more likely to follow through and execute it because it's them who's asking and wanting versus you as a doctor saying you got to do that. So we train in coach like this, listening to you talk about this and I don't know how much research you know or that you've spent reading up on ketamine, psilocybin, MDMA, it sounds kind of similar what is going on in the brain, what we're finding out about that stuff of what you're talking about. Do you know if it's similar in any fashion, do you know anything about that?

So that Beck was down a whole different, I know, a different road of, yes, well, it's different. In fact, my one of my best friends is the chemist for the biggest Canadian company in the world leading the research on MBMA and Silasibon and doing all these new projects now with, so you do know. Yeah, I lecturing it. It's totally different in its approach, but it's all working on, it's so interesting. Pathway in the brain, right? It's incredibly complicated, but it comes back down to an inflammatory state of the brain. It all comes back to kind of what in this area, how are you going to change these,

how are you gonna change these things called cytokines, chemokines and proteases that affect cells in a bad way? And so that what you just talk about, those things work in different mechanisms to do that, and GLP ones work in different mechanisms to do that, and GH And GLP ones work in different mechanisms to do that. And and GHRH and GHRP is BPC 150. All these things that we talk about,

they all have different ways of working on these mechanisms. But what I'm my point is that these, it seems like they're all, they're changing the how we think or we perceive or how we how. Well, let's say this, I think we'll get, that's a great, that's a great thing to bring up because I don't think it changes how we how well let's say this I think we'll get that's I'm great that's a great thing to bring up because I don't think it changes how we think it gives us back the opportunity to use those networks that we just haven't been using right that that we we're not changing it we're giving you back something that you've lost okay the. The best way it was explained to me, Dr. Seeds,

it's like you're on the top of a mountain, covered in snow, and you go down the mountain, and now there's already a path, and then you go down that same path again, and if you keep doing it, you make yourself a path that you're gonna kind of naturally go down, and going, and you're the way, you're met with lots of snow and resistance,

you might not even know that you can go another way, because there's this trail, right? So this is why like a habit, the longer you've been doing a habit, the harder it is to break. And so it sounds to me like what it does, it gives you like an option. Hey, there's other paths you could take,

and you could create other pathways, and then the longer you do these other things, now you have different behaviors. Yeah, you could look at it when one pathway and then the longer you do these other things, now you have different behaviors. Yeah, you could look at it when one pathway is dominated, all the other pathways are neglected, and that's kind of what happens. And so that's probably pretty true what you said. Okay, now, I know people are thinking of themselves

because peptides are different than drugs in this particular sense, in many sense, but in this particular sense, you take a drug, an opiate, let's say, or anything, right? It attaches to certain receptors, the body or the brain adapts by down regulating some receptors or upregulating other receptors. So then you go off the drug and you have these

exaggerated kind of withdrawal symptoms, right? So you go on an opiate, opiate receptors, 10, a downregulate, then you go off the opiate. Oh my god, I feel this pain because my body's at a whack. That doesn't happen with peptides like this one like are if we take a GLP1 agonist or we get a downregulate GLP1 agonist receptors and then go off and get withdrawal? Or is that's not happening? So nobody knows the answer to that. If they say they do, they're wrong. We don't know your thought process is right. There are certain peptides that if you use too much of something, it can downregulate

a receptor. But most of the peptides that we use, we use them in a physiologic fashion. We're just using enough to get a response and that's it. We're not over saturating a receptor. Now with the GLP1s, the argument can be made that, yeah, we are over saturating a receptor for a while. But it's my concept of these GLP ones is that what it's always been is that you utilize them initially to get the beginning process of what you want. And then, then we back down on the dosing. Now, is the dosing right now?

Is that physiologic? No, I don't think it is. I think it is super physiologic that we're using to make these things happen, because you have to initially. But I'll tell you, there have been long-term studies on the use of these showing no problem with saturation, not at all.

But I do believe, I'm always a believer in, okay, when you've accomplished something, let's start backing down a little bit. But I think GLP ones have a place for longevity, for a lot of things. So I like it there as a continued possible resource for people. Do they need to keep doing that? No, but I think if you have the time to explain the importance of how a peptide like that can change efficiencies. So what I'm actually telling you is that I think there's a world that's bright and amazing for GLP ones where there will be no issues like that at all. Are you seeing anything like withdrawal in your clinical practice? No.

So they'll go off and they're okay. Is there a hundred percent? No, I haven't seen it. And I've prescribed, I mean, this is the other thing that drives me nuts. You hear these people that talk about it and don't practice it and say, oh, my patients and they have five patients, you gotta have thousands of patients that you're working with to have to really make

some clinical statements maybe. And even when I make them, I always say, you know, this is what I see in my practice, but I have not, I don't see anything like that at all, as far as withdrawal from a GLP one, I don't see that. Is there a type of client who this isn't for, and what I mean by that is like, we talk about the health benefits for the average person for incorporating fast occasionally, right? You know, all the science that supports that there's health benefits to doing that occasion,

but there is a type of client that I would never recommend that to you, an example with somebody that struggles with bulimia and erection. I'm recommend that to you, an example with somebody that struggles with bulimia and erection. I'm not gonna teach them to refrain from food. They already have a really bad relationship with food. And so that would be an example of a client. I'm like, this probably isn't for you. Is there a type of client that you think that,

like, okay, this probably isn't for you, that comes to mind? What you just said is correct. And it's a, again, it's the art of the medicine or the physician and being able to realize those type of people that are, that you could harm more than her, right? And those are the people that want to use it more

to be in those states of those... And rex extrace. And that's something you have to be aware of. And we all see it, I would be remiss if I told you that I didn't see that and make those mistakes. I've had those patients that I didn't realize were those type of people. And it's a very difficult conversation

to have to back them down. And it takes a very difficult conversation to have to back them down. And it takes a while, but you have to do it. It's our responsibility to help them, but it's tough. It's very tough. Now another challenge is people are reading articles that ozempic is being sold out. It's really expensive.

You could get some agglutide as a generic, and that's still okay, right? Yeah. I think there's probably a misnomer in, and there was some people pushing a message there on that. I'm not gonna, I wanna get into the, I know everything behind that. Okay.

Interesting. And it's available for everyone. Are peptides able to be patented? Or is this different than drugs? Because I know that if ozempic was a, I wanna know the back story. Yes, I wanna know what I'm talking Yes, I wanna know the back story. I wanna know, I wanna know,

be as political as you can. And I wanna hear scarcity, you know why that was happening. Oh, there's just lots of politics, the handling. Is it like the DeBierre's diamond people in the mind? Yeah, that's right. Yeah, we're only gonna produce so much.

Or a new product that's gonna be a competitor Or a new product that's gonna be a competitor, or a new brand that's gonna be a competitor, or somewhere along those lines. Yeah, you guys are good. Just blink twice. Yeah. If we're crazy. Like you, we've been doing this for a long time, you know?

I've given you guys a lot today. Yeah. So are they able to not be patented peptides? Are they different than drugs? No, they're patented. Yeah, they can be patented, but you can add things to a peptide that can make it different. So these are much harder. I can mark it. Well, I was just going to say that my ozimpyc was also the most. Yeah, these sound like they're much more challenge, much harder to wrap your arms around as a pharmaceutical company and say, you can't touch this.

Oh, wow. Yeah. Because it is in a, it's a, the, the chemistry and the, it is more friendly in, in allowing you to work with a, a structure to make it even, maybe even more effective in certain ways. Do you foresee then, because look, the pharmaceutical industry is, I mean, they've done some remarkable things with also extremely powerful. And because of the way that our regulatory system works, I mean, just to develop a medicine

or a drug could cost you a billion dollars just to get through trials. Do you foresee them coming up with new regulations to make it easier to protect a peptide creation, or do you think, no, this is just, it is the way it is. Because as a farmer company, if I'm a farmer company and I see what you just said, oh, you can just change this. I'm gonna patent this, but they're gonna go buy it over here. Like, I'm gonna go lobby my Congress people and say, can we create some new laws so that I can do this?

That's how I thought. They are doing that. Okay. They're already trying to modify how many amino acids can be allowed in a peptide. So you can see. Yeah, it's already been done. There's already those senators that have flipped and

are owned by those groups and they make those changes overnight and they happen. But that being said, the pharmaceutical companies are, they're doing some great things because they're realizing that peptides are the cost of doing this is a lot less for them because they're because they're They're mimicking molecules that already part known in the body and so there's the the investment in something like that is much easier to to the investment in something like that is much easier to recommend to your investors because of less tolerance, less side effects, less, you know, they know there's a better course

of action because they're mimicking something we already know about, right? Instead of trying to make something tell us out and do something. I mean, do all these trials, see what the hell happens. Yeah. So it's open a whole new world of, I mean, the peptide science and studies around the world are in, it's insane right now where labs are focused on, on all of these different signaling agents that are, are, and they're easier to make. They're, they're not as expensive to make. So that's even better. And that's, that they're easier to make. They're not as expensive to make. So, that's even better.

And that's what we need. Yeah, so, because I would imagine one of the benefits is you can identify peptides that are naturally occurring. You have a place to start from. Correct. Not to go off on a tangent, because I know you're just a complete wealth of knowledge. But are you seeing that you... You tell that to my son?

Hey listen, I got kids too Billy, did you hear that? Yeah, he's super smart. That would go far. Not to go off on a tangent, but do you, are they doing more and more, I guess, initial trials in silica where they're putting these peptides, changing them a little bit, putting them in an algorithm on a computer, boom, it's spits out. So that's got to reduce the cost tremendously. Oh, the AI on this is crazy. Okay. It's crazy. Okay.

So, so just to kind of wrap around, there's a tetra peptide that came out for COVID that actually showed, you know, that it was developed by AI that was, that showed what the capabilities of a try-pept, a tetrapeptide could do. It never got to market. We're, I wonder why. We're having phases. It, it, careful, you're going to get a shut down here, too. I can't see.

I'm not saying anything. We'll talk off here. We'll talk off here. Just, just to kind of wrap our arms around this GLP, can I'm listening saying anything. We'll talk off here. Just to wrap our arms around this GLP. I'm listening to you and it just sounds to me like this could be a miracle substance. I never say, nothing is a miracle. But is there anything that even comes close to what the potential is for the something like this? There are a lot. Yeah, absolutely. There are lots of other

ones that we can talk about. But this one is the, in my opinion, has the most far reaching specifically for covering so many aspects of cell efficiencies. It's the one, it's the one peptide that has just, you know, it has so many, when I say pleatrophic, has so many different pathways that works on, you know, muscle, bone, brain, kidney, liver, you know, you name it. It has that kind of an impact, and it's, but more so, what I said is this, you know, how we're talking about changing, with all these peptides, we're working on changing phenotypes, and that's where we've got to get towards. That's precision

medicine is headed towards not treating symptoms, but treating the phenotypes that change to get those people into those states. Okay. Right. Because again, going back to insulin, you can give somebody insulin, you know, hyperglycemia, when you have too much glucose back to insulin, you can give somebody insulin, you know, hyperglycemia when you have too much glucose in your body, you give somebody insulin. That's a big bandaid, though. Yeah, it calms it down and people can survive and do things, but does it change what the cell, how the cell utilizes glucose

and what it does in the machinery of utilizing that to make energy, no, it doesn't. But GLP ones start to change that machinery. So just to kind of close this off here, because people could go, I thought we just got to go. This is the warm-up water. This is the one. So we got more to go. Someone could go online and, because you could do this right now, and I think this has to do with just loop holes in the law and they can find gel P1 agonist Research chemical companies and they can buy them online and Self-administer them and people are doing this. Yeah, that's scary. Any words of warning any advice for people who are doing this without going through the pharmacy without going through a doctor

Very scary. So I did a study, I actually did this study, but I think it was maybe eight years ago, where I did that and I took these, I won't say where from, but they were from multiple online sources of peptides to I did the, the, the, specifically looking at the makeup of what peptides were there, what wasn't there, what other substances, and it was, it was just not good. And I didn't even, I should have published it, but I would have been, I, I, I'm still may publish it. Um, it was not good. And in that meaning, so a peptide is a specific molecule of amino acids that depend on it being specifically what that is. So if it's a 15 chain amino acid, it's 15. Well, all 15 of those have to be there. They have to be right. And they have

to be bonded correctly. Let's say you only have 13 that are there and then the other three amino acids are different. Well, you don't know what those, when that, when you take that peptide, those other three will break off and you don't know what they're going to do. So you can be doing all kinds of weird signaling in your body, not even now. You have no idea. And that 13 chain, that part of that 13, you have no idea. It's what's, and it's, those things are what you worry about with cancer and you worry about with immune diseases and you worry about things that can go really wrong.

And that's the different, I mean, you've got something that has to be tested correctly, right? It has to be certified. It has to be, it has to have the antimicrobial check, it has to have the potency check, it's gotta have, that's why you have things that have to be regulated and have to be looked at. That's why you have to,

why would you administer something in your body like that that isn't from a trusted source. Yeah, and not to mention, you could be, someone could be taking these right now, I'm like, I don't feel fine. But these could be effects that might take months, a year, two years, three years to manifest, because maybe it's not toxic right out the gates, but you could be signaling something that it's not worth the rest. It's not worth the rest. It's not worth the rest.

I actually want you to wrap up with something that I think Justin was kind of alluding to and I think I want something a little more concise. I know that after this episode, we're going to have a ton of people that are going to want to start this, right? And so, and I know every, you've already said it that there's, you know, everybody has their own individual path and where you start them and when you can Introduce but if you were to kind of outline like you know, and then it doesn't have to be five steps But like the five steps if you get started on this

One step one obviously work with a doctor step two Have somebody who is gonna do some sort of therapy You know, however many times a month with you and And then, you know, is there a process, a general process that you would recommend most people that we're gonna go down this pathway of their kind of their mindset or what they should do. I'm sorry, I'm not.

What would you do? So, okay. I mean, I deal in an ideal world. So for example, like when I get a client, in general, would I tell people, before I start making them eat all crazy and different, I actually say, listen, I just want you to track and pay attention to what you're eating.

So we can become aware of what that is. Before I put you on some crazy workout routine five days a week and train like this, it's like, hey, let's go to the gym and we're just gonna do these few things, right? So I try and help clients build good behaviors before I kind of throw them through the gauntlet. So when you think of somebody who's going to listen this episode, they're going to go

try ozepic or whatever, you know, and they get going. What are some things that you would tell them as they start through that process? Well, hopefully they're working with a physician that has the experience to start implementing stages of a multiple discipline approach, you know, to what they're really there for, and that's to change their lifestyle. So I guess it's just, again, it's really tailored on the response of the patient and where, you know, the other thing I'll tell you, it's not an easy road, you know, using ozemic, you've got to be in constant communication with your patients because it is something

that not everybody, you know, we didn't really talk about that people can have side effects of nausea and fatigue and things that you have to work them through at the beginning. So it's not like it's just this thing you start and everything's great. You've got to, they have to know about that when you're starting that. And so they can be expecting that. But we build things into the programs to so they can be expecting that but we build things into the programs to To so they can be ready for that you know that that you're there you're

You're preparing them and they feel confident in their Approach and they understand that this is coming and then and you're they're undergoing a metabolic change in their body mean, you're changing the metabolism of these people that, of course, they're going to get fatigued. Of course, some things are going to happen, but you work with them and pushing them through that. And is that answer your question? Yeah. Because I said, so you are.

So what I'm hearing is that, you know, this is not something that you just should buy on the line or buy online and start doing your own. You should have a physician that, and not just any physician, a physician that actually is taking people through this process and can coach you through the different feelings you're going to have, whether that be the nausea or whatever. And then also how to maybe implement a strength training routine and then diet to work you through this in the future. Would it be safe to say, obviously, step one, do this with a doctor.

Correct. Step two, find a doctor who's got some experience with this, who also you can be in contact with. Not just, here you go, I'll see you in three months. Correct. Okay. Correct. And that is focused on those other changes.

I mean, wouldn't you want that person that's thinking about all those other aspects of my life to make this really work long-term, right? Because the goal is long-term. And again, the goal is to get them really interested in their health of where they're paying more attention to their nutrition and they're paying more attention to exercise. And and they're paying more attention to exercise. And then once that happens, oh my gosh, it's a totally different world and it's amazing because then you can start going down these roads

like what these other things you guys talk about, these other peptides, you know, the BPC, CJCs and the MataCES, SS31, all these things that can help enhance efficiencies. When you've started that process with these people, and they're already now ingrained in that, um, their zealots for health, it's a lot of fun then, because they're, they're, they're changing other people's lives too because people see their changes and they're happy to share their experiences with them. And then it just kind of keeps growing because they help them go down that journey.

And I've been able to see that too, which is really cool. There's a reason we're all talking about this. The reason is it works. The reason is we're getting healthier people that are taking control of their lives again. And I think that's really the most important thing. It's not people telling you, you know, take this box and this will make you better,

do this program, this will make you better, you're actually getting a whole mindset of, hey, you can make yourself better and you can, you'll dictate this pathway moving forward. Well, Dr. Seeds, this has been great. Yeah. This has been phenomenal. You've really shed a lot of light because we're all, I mean, being in the fitness industry,

we're always very skeptical whenever something comes out medicine or otherwise, it says, hey, this is all this is. Yeah, but, I mean, you have the background, you're also a fitness person, so this is incredible. I can't wait to see where this goes. We tell my son I'm a fitness person too. I think you can see that. Yeah.

Appreciate you coming on, Dr. Seats. Thank you very much. No pleasure. Thank you guys. Thank you. Thank you for listening to Mind Pump. If your goal is to build and shape your body, dramatically improve your health and energy, and maximize your overall performance, check out our discounted RGB Superbundle at MindPump

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