Mind Pump: Raw Fitness Truth - 2360: What You Need to Know About GLP-1 With Dr. Tyna Moore

Episode Date: June 17, 2024

How she got into practice and how she got into the GLP-1 space. (2:25) Peptide vs a drug. (10:45) The dose matters. (11:18) The GLP-1 deficiency factors. (15:50) Running into the resistance wall. (20:11) The downstream effects of GLP-1s on our metabolism. (22:15) The musculoskeletal impacts of GLP-1s. (25:38) Breaking down the GLP-1 peptides. (28:45) The thickening. (32:10) A wonderful tool/opportunity for people to get their lives back. (34:50) Wiring the brain through the use of these neurogenerative peptides. (37:48) Who is the best candidate for this peptide? (42:49) Addressing the fears surrounding these GLP-1s. (45:05) Is supplementation more important when on GLP-1s? (56:54) Understanding the incentives of a compounding pharmacy. (58:04) Speculating on the smear campaign against GLP-1s. (1:02:45) Why we’re Pottenger's cats. (1:08:56) Be an example to your children. (1:11:27) Addressing the autoimmune crisis. (1:16:13) The importance of educating yourself and being proactive as a patient. (1:18:57) Strength training is NON-NEGOTIABLE! (1:20:40) Lessons learned from her mentor. (1:23:25) One tool in the toolbox. (1:26:34) Her favorite peptides. (1:28:12) This is a slow and low process. (1:30:07) Why losing weight is the easier part. Maintaining it is hard. (1:31:25) Related Links/Products Mentioned Ozempic Uncovered Course Visit Entera Skincare for an exclusive offer for Mind Pump listeners! ** Promo code MPM at checkout for 10% off their order or 10% off their first month of a subscribe-and-save. ** June Promotion: MAPS 15 Minutes | Bikini Bundle | Shredded Summer Bundle 50% off! ** Code JUNE50 at checkout ** Ozempic: A Weight Loss Miracle or Metabolic Menace? A Discussion with Dr. Tyna Moore & Calley Means Trends and Disparities in Cardiometabolic Health Among U.S. Adults, 1999-2018 Adverse Effects of GLP-1 Receptor Agonists Evidence-Based Guideline for Adult Sedation, Pain Assessment, and Analgesia in a Low Resource Setting Intensive Care Unit: Review Article Healthy weight loss maintenance with exercise, GLP-1 receptor agonist, or both combined followed by one year without treatment: a post-treatment analysis of a randomised placebo-controlled trial Mind Pump #2110: Ozempic The Miracle Fat Loss Peptide: The Truth With Dr. William Seeds Mind Pump #2187: Why Building Muscle Is More Important Than Losing Fat With Dr. Gabrielle Lyon How Affordable Could Generic Ozempic Be? As Low as $5 a Month, Study Finds Pottenger's Cats: Early Epigenetics and Implications for Your Health TRANSCEND your goals! Telehealth Provider • Physician Directed GET YOUR PERSONALIZED TREATMENT PLAN! Hormone Replacement Therapy, Cognitive Function, Sleep & Fatigue, Athletic Performance and MORE. Their online process and medical experts make it simple to find out what’s right for you. Peptide World Congress – Seeds Scientific Research & Performance Mind Pump Podcast – YouTube Mind Pump Free Resources Featured Guest/People Mentioned Dr. Tyna Moore (@drtyna) Instagram   Website The Dr. Tyna Show Podcast Mark Hyman, M.D. (@drmarkhyman) Instagram Layne Norton, Ph.D. (@biolayne) Instagram Dr. William Seeds (@williamseedsmd) Instagram Leonard Pastrana. Pharm D Dr. Gabrielle Lyon (@drgabriellelyon) Instagram Drew Canole (@drewcanole) Instagram Lily Nichols RDN (@lilynicholsrdn) Instagram

If you want to pump your body and expand your mind, there's only one place to go. Mind pump with your hosts, Sal DeStefano, Adam Schaefer, and Justin Andrews. You just found the most downloaded fitness, health, and entertainment podcast. This is Mind Pump. Right in today's episode, we have a special guest, Dr. Tina Moore. Now a lot of you might know who she is, but we heard her first on a podcast. We're blown away. She's a brilliant naturopathic doctor. She's been practicing for over three decades. She has her own podcast that you should check out called The Dr. Tina Show. Great podcast. She also has a great course. It's called Ozempic Uncovered. In fact, today's episode,

we talk all about GLP-1s. She's been working with them for a long time by the way. She has information and protocols for GLP-1s that we haven't heard about yet like taking lower doses, what GLP-1s are good for besides just weight loss and how to use them properly and all of the different benefits and stuff we're seeing in the study. So if you're curious about things like Ozempic or Wigovie, like this person is the person to listen to. We consider her one of the best authorities on the topic. By the way, her Ozempic Uncovered course

you can get at Dr. Tina, Tina spelled T-Y-N-A, so drtina.com forward slash Ozempic Uncovered. Go check it it out but in today's episode it's gonna blow your mind we know you're gonna enjoy it. Now this episode is brought to you by a sponsor in teres skincare so they use the science of peptides to get your skin to rejuvenate to heal to grow to look better like there's nothing like this on the market this is peptide technology for your skin They also have a product for your scalp that regrows hair This stuff actually works and you won't find anything like it anywhere else. Go check them out. Go to intera skin care calm

that's e NT e are a skincare calm forward slash Mpm then you use the code M p.m You'll get 10% off your order We also have a program sale this month. MAPS 15 is half off, the bikini bundle of workout programs is half off, and the shredded summer bundle of programs is also half off.

If you're interested in any of those, go to mapsfitnessproducts.com, and then use the code JUNE50. All right, here comes the show. Dr. All right, here comes the show. Dr. Tina, welcome to the show. Welcome. I gotta say, I'm a little bit embarrassed. I didn't know about you until recently.

Why did it take so long? So we all listened to you on a podcast, and the podcast was Dr. Hyman's podcast, and it was about GLP-1s, and we're really diving deep, and we think that this is like a culture shifting medical intervention potentially. We listen to the podcast and I'm like, who is this woman?

And so I started going into your stuff and I'm like, we love you. We love what you said to say. You had a very nuanced approach. You took completely no disrespect to the other gentlemen on the podcast, but you wiped the floor with the guy that seemed like a debate.

And so we wanted you on the show to talk a little bit about these and what's going on and how you approach your patients with GLP-1s and in just general, how you approach health, because we think your message is remarkable. But let's start with your background a little bit. What do you do, how long have you been doing it, and then we can get into everything else. Yeah. Well, thank you for having me. I'm so excited. I've been huge fans of you guys for years, so this is epic. So, I'm a naturopathic physician and I'm a chiropractor. And I got into practice long before I actually got a license. I ended up working for a naturopathic physician starting in the early 90s, right out of undergrad. And he was such a total Jedi.

And I spent 20 years with the man and he passed away from cancer in 2013. By then I was a licensed chiropractor and a licensed naturopathic physician. And he handed his practice over to me and I learned from him about my entire specialty was regenerative medicine. So I was putting people's joints back together. I was using prolotherapy, PRP, stem cells long before it was cool, like just me in my office, just cranking it out, super busy. And I learned bioidentical hormone replacement from him.

I learned the art of prescribing medications appropriately for the patient sitting in front of me. So not necessarily going by standard dosages, but actually meeting the patient where they're at. And when you improve lifestyle and you improve their health overall, it's like a teeter totter, you get these pieces put together and then you can lower the dose to the minimal lowest dose necessary. So it's physiologic dosing, not necessarily pharmacologic dosing.

So microdosing, antidepressants, microdosing hormones, like just meeting the patient where they're at and titrating them up until they feel better. And so I did that for a long time. That was my practice. And then right before COVID hit, conveniently, I actually closed my practice because my online business was taking off and I couldn't do, I was managing everything. I was a single mom with a teenager and it was all too much.

So I'm glad because I was in Oregon and things went a little crazy in Oregon. So being in practice through that would not have been that fun. So got out of practice, COVID hits, and then I found myself sort of in the eye of the storm of just pushing you know, pushing back against that narrative and my following grew really big, but I got severely shadowbanned, that's probably why you never heard of me.

They sort of kept me in a little, you know, over here with a little lid on it. And I stumbled across GLP Ones actually, I share the COVID part because during all of that, I got targeted politically. I shared with you guys a bit off the air and I was under a tremendous amount of stress and my autoimmune disease just went crazy and I ended up in just severe chronic pain. My spine was fusing quite literally and I was having psoriasis breakouts and I was a

mess and I was looking for something that I was doing everything. I have access to stuff that like you guys can't get, you know? And I was doing everything, everything you could think of and more, and nothing was touching it and I was walking headlong into menopause at the same time. So it was like the perfect storm and everything was culminating. Suddenly I started losing muscle mass. I was wasting away because my spine was under attack from my immune system. So it was like the perfect storm and everything was culminating. Suddenly I started losing muscle mass. I was wasting away because my spine was under

attack from my immune system. I, you know, I went carnivore, I went strict, I did all the things and nothing was sticking. Nothing was really holding for too long. And then this whole Ozempic thing blew up and I have a podcast and I was, my producer actually was like, we have to do a piece on Ozempic. And I thought, well, I don't really know anything

about this. I'm not going to speak on something I'm unfamiliar with, you know, like that's just not, I don't talk out my butt about things I don't know, like some influencers seem to do on the internet. So I actually, when I had the bandwidth, I started researching it. And because my background was in pain and regenerative

medicine specifically, that's the first thing I look up is like, how does this substance impact? First of all, what is it? What does it do? And then how does it impact pain? How does it impact neuroinflammation? Those are always the first things I look up when I look up any substance. And it turns out it's a peptide.

And I'm very familiar with peptides from the regenerative medicine space. So you know, things like BPC 157, TB 500, you know, there's lots of peptides that we've used over the years. And I was like, huh, this is a peptide. Why is it, why has it been appropriated by a pharmaceutical company or two? And it's because of the delivery, because it's injectable. So, it's not really a drug. It's a peptide. And peptides are just strings of amino acids and strings of peptides are because it's injectable. So it's not really a drug, it's a peptide. And peptides are just strings of amino acids

and strings of peptides are proteins, that's it. And so peptides insert themselves where they need to go and they heal tissues and they're regenerative. And I thought, well, I'll be damned, this is a peptide. So this can't be the horrific substance everybody was making it out to be. There had to be more to the story. So I'm a total nerd and I was like, and I'm

insubordinate to the core. And I, whenever anyone runs, everyone runs this direction. I'm like, you know, I'm like, I'm not going over there, but what are you all doing and why? And, and I thought it was so weird that the same people that were part of the medical freedom fighting community who were like the media laws

were all parroting the media around this topic. Like that really raised an eyebrow and I thought, well, this is weird. So I start looking into the data and there's like 20 years of data on this family of peptides. There's earlier generations before semaclutide and trisepatide. And it turns out they're regenerative to,

from like tip to toe, particularly for the brain, which is phenomenal. We don't have anything that regenerates neurons readily available to us. We don't have anything that decreases neuroinflammation. Most pain and hormonal conditions and chronic illness and autoimmune conditions really start in the brain. It's a brain inflammatory process. So I remember sitting on the couch, reading

these studies going way back and I'm looking at my husband and I'm like, they're fucking lying. Yeah. Like this is not, and I'm flipping through studies and I'm such a dork and he's, he always just humors me, he's like, yeah, baby, that's good, you know, that's nice. And so I kept digging and digging and I found

data around regeneration of heart tissue, cardiovascular tissue, kidneys, pancreatic function. If you get these GLP-1s in someone who's diagnosed with type 1 diabetes early enough, you can reverse type 1 diabetes. We know that type 2 diabetes is, what, like 2018 data that came out in 2021 showed that about 94% of US adults have cardiometabolic dysfunction. So they're on the road to diabetes. 94%.

94%. Wow. And that's 2018 data. So that was pre-lockdown. Right, so it's gotta be worse. Oh, way worse. Yeah. And so I'm looking at this, and my whole background,

even though it was in pain and regenerative medicine, I was always addressing metabolic health. I was always telling people to lift weights. I was always addressing metabolic health. My colleagues were giving me shit years ago, like, why do you run serum insulins on everyone? Why are you so worried about metabolic dysfunction? And here we are 20 years later and everybody

has metabolic dysfunction. Yeah. And suddenly it's cool to lift weights, you know, like you guys obviously know, but I was like a skinny gal, you know, seven, eight years ago being like, eat steak and deadlift. And everyone was telling me to do yoga and be vegan.

So anyway, I did a podcast about it and it eight years ago being like, eat steak and deadlift. And everyone was telling me to do yoga and be vegan. So anyway, I did a podcast about it and it blew up. And then people just started coming in and I started hearing stories from everybody, real people using these peptides telling me about these really profound life changing events in their lives while being independent of weight loss. These impacts are independent of weight loss. That's what got me going.

So I want to get into that, but I want to back up for a second. You said it's a peptide, not a drug. So correct me if I'm wrong. Peptides, they already exist in the body and the body knows what to do with them. So it's a signaling system, it's already in the body. Whereas a pharmaceutical is when a pharmaceutical company

takes a drug or creates a drug and they try to shoehorn it to work on a receptor to kind of cause things to happen. But it's not something that your body necessarily recognizes or exists in the body. GLP-1s, we have GLP-1 hormone. Right, we make it naturally, endogenously. Okay, so that's why it's different than a drug.

And then you mentioned microdosing. The dose of the medicine makes a big difference on how it acts on the body. Large dose can cause a completely different reaction than a low dose or a small dose. And so what you're saying is what you would do with your patients is you would modify their lifestyle and then as the lifestyle got better, well now we can lower the doses of these medications here and get them to kind of work better, more synergistically. Right.

Well, that's the other thing that blew me away was why were they cranking these doses into patients at such high levels, and then they escalate the dose very quickly. It's like a 16 week ramp up to these incredibly high doses. And I thought, well, at the end of the day, a signaling peptide is a hormone. You can think of it that way.

So if we were cranking crazy high levels of testosterone into someone or thyroid hormone or any of these other substances into somebody, they would have horrific side effects and we would blame the doctor and we would say, well, this is like a dosing and management issue. We wouldn't blame the hormone. It's not the hormones fault. It's the way it was handled in the body. And so I got this idea and I started calling all my friends,

all my compounding pharmacy friends, all my functional medicine friends, all my peptide buddies who were doing peptides in their clinics and I said, are any of you microdosing this? Like tiny little, because I got this idea that we can come back to that there's GLP-1 deficiency.

I really firmly believe that there is GLP-1 deficiency. So your body's just not making this GLP-1 signaller like it should. So you're just not getting the signal. You eat, not getting the signal that you're eating, so you just appetite. Well, GLP-1 works in conjunction with leptin and ghrelin. And without GLP-1, leptin and ghrelin don't do their thing. And leptin and ghrelin are your two main appetite hormones. Leptin is secreted by your fat cells and it tells you there's enough energy in the system or not. And so it has a lot to do with appetite. And then ghrelin are your two main appetite hormones. Leptin is secreted by your fat cells and it tells you there's enough energy in the system or not. And so it has a lot to do with appetite.

And then ghrelin is secreted out of your stomach. And it's, I think, ghrelin grr. It tells you you're hungry. So, you know, it makes your stomach grr. And without GLP-1 on board, and I only found this in mouse studies, they were looking at receptors and mouse studies and the ghrelin and leptin receptors don't adequately signal and don't even present

themselves to be bound correctly without GLP-1. And then I found data showing that, and we know this, this is all over the place, obese folks, folks with type two diabetes and folks with fatty liver, which is all kind of that metabolic dysfunctional soup, those folks are indeed GLP-1 deficient. So I started asking everyone, are you, are

you microdosing this? And all I got back from everybody was, and there were lots of cool docs using it, but they were using low doses for weight loss. And I was like, no, no, no. Are you using it for anything else? Like, are you, they sit on your immune cells. GLP-1, there are receptors on your immune cells.

So I thought, why are we not using this for autoimmune disease? Why are we not using this to mitigate neuroinflammation? Why aren't we using this to mitigate high blood pressure and all these other conditions? And nobody was using it that way. So I started doing that. I was my first guinea pig. My husband was my next guinea pig.

Every one of my family members, every one of the patients I still care for, I don't have, I don't have very many patients that I'm taking care of anymore, but I have a big audience and I have a decently, I don't have a platform your guys' size, but I have a decently large platform and I was having hundreds of people message me ever since I released those podcasts telling me about these profound impacts they were having. Now what was your autoimmune issue?

It was psoriasis? Psoriatic arthritis. Okay, so this affects the bones. And you noticed that when you went on your GLP-1 that that helped a lot with that issue. A lot. So my joints feel like they're gluing together and cementing together and it's a stiffening. I can't even describe it. It's so horrifically painful and everything pops and moves when I'm on a tiny little dose.

And then what I figured out, which is my hypothesis, if somebody's really metabolically sound and they have good muscle mass, they just need a tiniest little touch, like just the tiniest little bit. And so everyone says, well, what's the right dose? It totally depends on the person. It totally depends on like who's sitting in front

of me, what's the short term goals, what's the long game, what are we doing, what are we trying to treat, you know? And so I found for myself, like literally droplets. But I think that that being impactful and effective is reserved for those who are metabolically healthy. Those who are less metabolically sound, they need higher doses. Which is probably why they came out and had this generic dose.

Cause originally 20 years ago, we're only using this for people with diabetes and that need to lose probably 60, 100 pounds. And so it makes sense that they're slamming them with that big of a dose. Yeah. In terms of like the GLP-1 deficiency, like, so is this all like environmental factors to that or is there actual genetic factors in there

as well? Both. So there are genetic, okay. So GLP-1 is not just made in the gut. Everybody thinks, oh, it's made in the gut. It's a gut hormone. It's made by the L cells. It's secreted in the presence of bitter herbs.

Any food that you eat, just the bolus, the mechanical bolus of food going through will actually stimulate the L cells. There's lots of reasons, but in my world, every patient I saw had a messed up gut. Like everybody's got gut inflammation to some degree, mild or severe, leaky gut, dysbiosis, parasites, whatever.

So I thought, and aging, an aging gut is an atrophying gut and the cells just don't work as well. Like when we get, when we age, our stomach starts to atrophy, our stomach lining, and we lose intrinsic factor and intrinsic factor is necessary for the absorption of B12. That's why we see B12 deficiency in folks as they get older and we lose intrinsic factor. And intrinsic factor is necessary for the absorption of B12. That's why we see B12 deficiency in folks as they get older and it leads to dementia.

So I was thinking in terms of that, like, well, we could try to stoke the L cells to work, but they might be toast, right? Like I've had gut issues my whole life. My mom has Crohn's disease. I don't see us getting great stimulation from some berberine on this one, you know? Like I think we might need to supplement.

And so I started using it as I would bioidentical hormone replacement. I started using it in the doses that the person in front of me needed to replace what I thought they needed. So we titrate up until we hit saturation and saturation usually means side effects. So we start to get the nausea or the, you know, GI,

maybe it's constipation, maybe it's diarrhea, maybe they start to, they'll randomly say, you know, I threw up yesterday. I'm like, we got to lower the dose. That's saturation point. And so with that, I just found across the board that those who are metabolically healthy and have muscle mass and take good care of themselves and eat

well, just need the tiniest bits. And those who are metabolically healthy and have muscle mass and take good care of themselves and eat well, just need the tiniest bits. And those who are not definitely need seem to need more, not always, but seem to need them. Now you said something earlier. And so here's my, this was my dilemma with it is when you hear about the, the benefits of GLP ones, reduced inflammation in the brain and the

body, uh, healing of heart tissue, organ tissue. I'm like, okay, well you see that when people lose weight and lose body fat. When you go into calorie deficit, all these miraculous things happen. You see blood, you know, you see someone's labs all improve. I mean, there's people on social media that have done this. I think this is a terrible way to display this,

but you'll have somebody like, I'm in McDonald's only, lose weight and show improvements. They're in a calorie deficit, right? So obviously they're gonna feel like crap, but you still see improvements because it does seem to fix a lot of stuff. You're saying that there are benefits independent of the caloric deficit.

And is there data on this in studies or is it really? So how do they show this? What do they look for? That's what I wanted. You brought up the, and this is that you started this, we're talking about the bringing down the brain inflammation and cell regeneration. And we know that like if fasting can promote some of this. And so is it because you're basically doing a fasting mimicking diet that you're getting

those benefits or is there actually something in the GLP-1s that are causing that? Can we parse that out? So GLP-1 is made in the brain as well as in the gut. They used to think it was made in the gut and it crossed the blood brain barrier, but it's made in the brain. There's two regions in the brain that make it, and there are receptors throughout the body for it. So there are receptors in the heart, there's receptors in all your organ tissues,

there's receptors on your immune cells, your mast cells, there's receptors on your neurons. So when the GLP-1 binds those receptors, that's the impact that it has. We don't entirely understand what it does because they haven't studied it well enough to, you know, flesh that out. But we have rodent data showing really cool stuff and we have some human data. Anyway, it binds the cells of these organ systems and it has its impact there directly. There was even, what was I looking at the other day, they found that even without receptors

present, GLP-1 had impact that was positive. So it just being in the region was having positive impact. Interesting. I can't remember which organ system was, it was, I'd like been knee deep in studies. So even without the presence of receptors. So there's something about it that I think needs to be looked at further.

Do you think the GLP-1 deficiency or resistance or something that people are developing is like similar to like leptin resistance connected? And do you think you get someone who's been obese, unhealthy, metabolically, they don't exercise, been in garbage for a while, that that makes the issue worse with the GLP-1 deficiency over time? I don't know, but I know that with all the other

signaling peptide hormones, like ghrelin and leptin and adiponectin and all of those, insulin, insulin's a peptide. Yeah, you become resistant to that. Nobody talks about that. Nobody has any issue with people being on insulin, it's a peptide. Right. You end up with deficiency. So in the type two diabetic gone on long enough,

they will end up insulin deficient, but they're insulin resistant at the same time. So my concern with these is are we dealing with GLP-1 deficiency in this group? Yes. And then do they have GLP-1 resistance? We don't know. Maybe that's why they need to crank the dose

up so high. But I do think that with those high doses in a sustained manner, they are going to develop resistance. So those folks, one of my friends is a compounding pharmacist and he was telling me people are, they're hitting the wall and they're calling saying, can I go up?

Can I, cause 2.4 milligrams is the high end of that dose. Can I go up to three? Can I take more? It's not working anymore. So that's what we're going to see next is people running into that resistance wall because peptides aren't meant to be cranked.

No hormone really is. You're not supposed to crank a hormone and stay on it forever. You're supposed to cycle it. You're supposed to rotate it out. Your body, your body adapts even with testosterone. You see that some bodybuilders take super high doses. Their androgen receptors start to get saturated and even down regulate, you

know, in some cases to, so become less sensitive, uh, to the hormones. So your body's becoming less. So you think if we don't approach this properly, we're going to end up making a lot of people like kicking the can down the road and potentially making it worse by creating more issues with resistance towards these hormones or these. Especially considering it's in these companies best interest to keep selling it to you and keep you on it for life.

So they're gonna be communicating it one way and then you're gonna be seeing this come out the other way. So when you work with patients, because right now the reason why it's going mainstream is because you lose weight. It's like, you know, it may have all these other benefits but people lose weight on it so now everybody wants to use it and that's the big thing. It's obviously very profitable as a result.

With your patients, what percentage of them are using it for weight loss and what percentage would you say are using it for the other reasons that you mentioned? Or is it just kind of... So everybody that I put it on had a little bit of fluff to lose. And it maybe was five pounds, 10 pounds, 15 pounds. And in most cases, I think a lot of that weight that we sort of pack around that we can't get off, I think a lot of that's inflammatory and I think

it's just immunologically driven. And so what I saw was everybody sort of lost the, whatever that layer was, and they just got down to their fighting weight, like where they felt good. Like I dropped right back to where I was in 2019 before all the stress hit. I just went like, boop, really fast. I dropped right back down. I was like, okay, I'm back in all my clothes.

Everything's the same. If I want to crank the dose up, I'll get nauseous and I'll lose more weight. I don't want to do that. I'm not trying to do that. I'm not trying to get like six pack abs or anything. I'm using it for my immune system and for my brain and brain fog. It's also a phenomenal antidepressant I've seen

and it's reversing PCOS, it's reversing depression, it's doing all kinds of great things for the brain. So anyway, one person, I've got one person who's obese and diabetic and it's my dad and he's, he's old and we were losing him. I mean, he just completely checked out and I thought, you know what, I'm going to crank the dose up on you, dad.

You got one foot in the grave. You're going anyway. Like we, every Christmas, it's like it's our last Christmas with dad. So I was like, I'm putting you on jail for ones. The other thing is I found data showing significant reduction in like, I think it was 18% reduction in pneumonia

with upper respiratory infections. And then I found another study that was from 2021 in the, I think it's the Journal of Diabetes, this is crazy. They had diabetics, type two diabetics present to hospital with COVID. They administered some acrytide once a week, they administered some acrytide once a week, 80% reduction in ICU admission and death. Okay, so let's speculate a little bit because this is fascinating.

So that's why dad went on the Ozempic for the winter because I was like, we're not dealing with pneumonia again this year. So yeah, let's speculate a little bit because they do, GLP wands do improve or increase insulin sensitivity. Now we know in the data, if you have a lot of muscle mass, you're far less likely to have issues with COVID. And they think it's the insulin sensitivity, brain fog, insulin, I mean type three diabetes, diabetes, right? Alzheimer's, dementia. Independent of the weight loss, these do improve insulin sensitivity. They do increase the uptake or improve the uptake

of glucose, glycogen, amino acids in the muscle cell on their own, right? Yes. Okay. I think they heal the metabolism overall in a myriad of ways. I think they make the cell more insulin sensitive. I think they heal the pancreatic tissue.

I think that they have an anti-inflammatory impact, which downstream is gonna help. They help with the leptin and the ghrelin. So all in all, I think the longer someone's on them, if done appropriately, I think it's healing the metabolism long-term. It's a regenerative impact on the metabolic health of the individual using it.

So here's what's interesting, so Adam went on terzepatide as a way to be able to communicate this to our listeners. And he's like, I'm going to do this like the average person. I'm going to take it. I'm not going to try and do my bodybuilder tricks. I'm just going to see what happens. And it was invaluable because now we can really communicate and understand kind of what's

going on from his perspective. I microdosed it and now this is week three on a microdose. I don't have any appetite suppression, I don't think, but I was noticing and talking to them, I've been noticing in the gym, I'm getting, and I'm very sensitive to this, I could tell, I'm getting really good pumps in the gym. I feel kind of like what's going on. So last night I got in a rabbit hole and GLP-1s in animal studies improve muscle modeling through the up studies improve muscle modeling. Yes. And through the uptake of amino acids.

Yes. Now, the reason why I never looked here to begin with is because you hear the muscle loss when people are on GLP-1s at high doses because your calories are low enough, it doesn't matter what's going on, your body's going to try to adapt by reducing your metabolic rate by paring muscle down. I'm on this microdose and I'm like, this feels anabolic. I feel like I'm kind of building muscle and then lo and behold, there's all these studies on GLP-1s

improving stamina, endurance, and essentially what they said is, I think it was muscle remodeling or muscle tissue remodeling. So explain that a little bit. I know it's nuts, right? When I'm on it, I feel like when I'm on testosterone. Honestly.

Like I get the same clarity of thinking that I get when I'm on it, I feel like when I'm on testosterone, honestly. I get the same clarity of thinking that I get when I'm on testosterone. I get the same, the strength gains. My coach is like, why are you so strong? I was like, I don't know, but I'm taking the tiniest little bit of tersepidide and it's awesome. So yeah, there's human data and there's rodent data showing improvements through blood flow. So improved blood flow. Is this nitric oxide or is this through vascular?

They don't know, cause nobody's really looking into it further, but they're finding improvement in angiogenesis in blood flow to the muscle tissue, which delivers the amino acids better, which would improve muscle protein synthesis. It has really cool impacts on the joints and not only the bones, but the joint capsules, the, you know, chondrocytes and the, in the cartilage. It's, it's very cool. So all kinds of

great musculoskeletal impacts overall, and it's all regenerative and it's all healing and it's all anti-inflammatory and it does not induce muscle wasting whatsoever, not directly by any means. It's what you said. People are just going low calorie, they're eating the same old garbage, they're just eating a ton less, they're cranking the dose so high that their appetites are getting crushed so they don't eat anything and when they do, they're not choosing any foods that are muscle protective so they're not priorit prioritizing protein, and then they waste away, which in the long run is gonna be a disaster for that individual.

Yeah, it's actually muscle sparing, is what I've been reading. It's a muscle sparing peptide. Now, if you go low enough calories, you can take whatever. You can take all the testosterone growth hormone you want, you're gonna lose muscle, but it has on its own, it seems like, like I said last night, I went crazy. I was reading these studies and I was blown away.

Now where are we going wrong? Where are we going wrong with the, it's just the over prescription, we're giving people too much and destroying their appetites. My wife tried it, took the recommended dose, and she's like, this is like the first trimester pregnancy. I don't like this. I can't eat, drinking water was difficult for her.

Is that what we're going wrong? Or are there differences too in the different medications like your Ozempix and like, you know, Trezapetide for instance, just those two in comparison. Yeah, so semaglutide is also known as Ozempic or Wegovi. Ozempic's FDA approved for type two diabetes. Wegovi is type two, it's same thing, is FDA approved for obesity.

And then Trezapetide is known as Monjoro and ZetBound. And those are your type two diabetes and your obesity. And, semaclutide is just a GLP-1 agonist. So GLP-1 sits on the receptor, it induces insulin secretion and it inhibits glucagon secretion. Teresepatitis is a GLP-1 agonist and a GIP agonist and GIP induces glucagon secretion.

So now you've got insulin secretion and glucagon secretion and you would think that's not great but it seems to only pulse these as needed. So remember I said with the type 2 diabetic, you could end up with this insulin deficiency and resistance at the same time. This helps sort of mitigate that and mediate that so that things are pulsing when they should and the cells are hearing what they're supposed to hear and things are happening the way they're supposed to happen. And when you have a little GIP on board, it seems like the GLP one works better.

The terzapotide is better tolerated, less side effect profile. Um, the semaklutide, I have found semaklutide to be more effective for actually something we haven't talked about yet, crushing that hedonic urge of alcohol, smoking, shopping, anything that's like that dopamine dragon chasing. For me, something I noticed that I had not been aware of until it went away is that I tend to,

I'm just addicted to cortisol. I always have been. I kind of came out that way, you know, came out the shoot, my mom had a really difficult pregnancy and I came out just sort of like craving stress, I'm that girl. And I'll feed forward into the thought patterns with it.

And I don't house to explain it, except when it was gone, when I'm on GLP-1s, it's gone. I don't ruminate into stress. I don't feed forward into these loops in my head. I just look at this, I'm like, that's not my circus. Next. And I've had people reach out to me and tell me that their shopping habits have significantly diminished, that they were rabid online shoppers and they didn't even realize

it. That's how they were getting their dopamine. There is a HPA axis impact and a dopaminergic impact that they don't fully understand, so there's something happening there, but I've noticed that it's not as effective with trisepatide. With semaclutide, I do not want alcohol at all. Um, and that those urges are really crushed. With trisapatite, I actually have a better

appetite, but it's weird cause I'm eating the same amount of food and I lost weight. So I think there's an impact happening beyond just caloric restriction leading to weight loss. I think there's something about the insulin sensitivity and the overall impact that it has on the metabolism that's leading to weight loss. I think there's something about the insulin sensitivity and the overall impact that it has on the metabolism that's leading to weight loss as well, in addition to. Now you say use them both, so I'm assuming you go on one

and then you'll cycle to the other one. And do you think, do you do that with your patients as well? Is there a benefit to doing that? Well, most of my patients seem to feel good on some acrytide and it's much more affordable for people. It's a third to a quarter. I use compounded and that's like a third to a quarter of the price of terzepotide. But I have found for myself personally that I jump back and forth depending on what I'm going for.

I feel like, and I don't have any proof of this, I feel like the immune benefits are stronger when I'm just dealing with a GLP-1. And I don't know if I need the GIP because I am so metabolically sound. So people who might have a little more metabolic dysfunction and you can have insulin, you can't see it on labs. Like my labs look perfect, but I had insulin resistance. I gained 20 pounds out of nowhere and I knew it.

I was like, damn it, what happened to my middle-aged women patients was happening to me in real time. I was watching it happen and I was like. You hear this, I used to hear this from female clients and I'm ashamed to say that I dismissed them as a young trainer. Yeah. It's like, oh, I just turned this age and all of a sudden

everything changed and you hear this as a trainer, like, well, you're probably eating more, probably not working out as much or whatever. But then I heard it so many times, it's like, okay, there's something to this, and so you experience it yourself. It was in real time, I call it the thickening. You've probably seen it, these beautiful,

go look at all the beautiful actresses that are my age, like all the ones that were big, like the 90210 crowd, they all got thick, it's like this thickening that happens, and they're active, they're working out, they're eating well. Some of them are eating, my patients would be like, I'm eating less than I ever have. I'm starving and I am getting thicker. There's just like this coarseness that takes over. So I would throw, I mean, I was running laps on all these women and I was feeling like you were like, they've got to be doing something here. I'm in my 30s and I'm like, haha, everything's fine. And they're like, I used to look like you.

And I'm sitting there like, oh God, don't let this happen. My whole family is just a bunch of like type two diabetic little potato shaped people. So I knew it was coming and I was like, and it started happening in real time and my labs were perfect. So I'm running labs on these women. I'm throwing thyroid at them. I'm throwing hormones at them. We're doing everything. We're doing everything right. They eat like saints, we're doing everything right. And it just wasn't working. And I do believe there's a cellular level insulin resistance that we can't see on labs,

but that is happening in people. So it could look pristine on lab work, but I was having it. I was like, I am insulin resistant, my midsection, my waist circumference is growing at an exponential weight and I'm not doing anything. We're not able to measure it yet with labs, but there's enough people, enough anecdote, there's something going on. I just read a study, my friend Lane Norton just posted, it was a two year study on GLP-1s

and they had people go on them and go off of them. They had a placebo, they had a group that was on the GLP-1 and then off and then a group that did GLP-1 plus exercise and then came off. And the group that was on the GLP-1 and came off gained the weight back. Yep. Okay. The group that was on the GLP-1 and exercise and then

went off the GLP-1 but continued exercising, gained back significantly less weight. And he said, it's not the calorie burn. They weren't doing crazy hard calorie burning workouts. I think it might be more like what you're saying where the exercise, especially strength training, help maintain the insulin sensitivity that the GLP-1 helped come about. Are you familiar with this?

Yep. What I'm saying? Yep. I know that study and there's another one where they show just really basic exercise, people who were moving versus people who weren't moving, who went off the GLP-1s maintained better weight loss. So I think it gives you a window of opportunity. So if it is inducing a healing impact

on the metabolic health of the individual and they're on it for a period of time, they should become more insulin sensitive, not just because of the peptide, or not just because of the immediate impact of the peptide, but long-term they're healing. And then this gives you a window of opportunity to change those eating habits.

Cause the one other thing that we haven't talked about is it really puts the onus of control back into the patient's, they're in the driver's seat. So I have way better control over my thoughts, my actions, my food choices, everything when I'm on them. There's something about my brain that really likes GLP-1. I think I had a deficiency.

I think, to be honest with you, I haven't felt that kind of normal feeling in my brain since I was 14. I went on it and I was like, oh, this is what it felt like before the lights went out when I was 15. When I was 15, the lights went out and I went into a deep depression and I have struggled with depression. But I think a lot of it was my immune system. I think it was inflammatory.

I think it was neuroinflammation. And so maybe that's the mitigating part. Regardless, I've seen it turn around neurodivergent folks successfully, like get people out of that ADHD looping kind of not able to get their work done kind of thing. And I think if they're on this long term, we, for someone like me, I plan on staying on it forever,

just like I do my hormones and I'm going to cycle it and I'm going to rotate it. But I think that folks might actually be given this opportunity to partake in that healing. So not only is the peptide doing the work, but if the person who's using it is strength training and they're changing the way their relationship is with food and they're changing their relationship with stress and they're changing their relationship with however they were living that got them into the mess in the first place, it's this really wonderful

window and we can use this as a tool to give people this opportunity to get their lives back. Well, to keep going down that rabbit hole, that study that Lane posted, in the conversation that we had Dr. Seed that I thought was really fascinating was after we wrote the program and we were talking to him and he said, you know, there's also something that's happening behaviorally. So just them getting in the habit of creating this new routine. So there's probably some carryover from that. So if you have a group that is also exercising

along, regardless of the intensity, the volume of all this stuff or how great the program is, just a habit of training while you're on it. Yeah. When they come off, that habit seems to be sticking versus someone who didn't even create that habit at all too. Yeah.

Well, so habits are either strength and or weekend. And the way the strength is you maintain them and the way that the weekend is you stop doing them. And so if you change your eating, because your appetite. Yeah, but that's normally I'm saying with the GLP. Right. That's already, we already have that established, creating a habit of behavior.

That's what I'm saying. So it reminds me of like, I used to train, I trained a lot of doctors at one point and I had a psychiatrist I had trained and she said, sometimes the way she uses SSRIs, for example, she goes, you know, exercise and diet are phenomenal for depression and anxiety. Sometimes someone is so depressed, they can't even get off the couch. So I give them enough so that they can then go do the things that help with the depression and the anxiety.

And then we can lower the dose of the SSRI. It's almost by the way, you're not the first doctor that I've talked to. He's talked about jail. But Dr Seed's mentioned this as well. It almost sounds like that. Like this is going to help get things moving in the right direction. Then we develop these behaviors and then we could take it from there.

Plus it's neuro regenerative. So in my head, I'm thinking about neuroplasticity. Yes. I'm a chiropractor. Like that was my original training was as a chiropractor and that's all about neuroplasticity, right? Like we are retraining the brain and reprogramming

tracks in the brain to get people out of pain, to get them moving, whatever it may be. And so if the way that I'd explain this to the folks I put it on is I said, this is a window of opportunity for you to not only make short term changes and develop new habits, but we're wiring, and my hypothesis is that we're wiring the brain through the use of these neuroregenerative peptides. So whatever habits you instill over the next however many months or however long we decide

to do this are going to be much more permanent because of the impact of the peptides. This also highlights too though why I think it's so paramount that it's paired with, you know, a doctor, a coach, somebody working with them. Because even like, and we haven't addressed this yet, but I remember bringing it up to the guys, like one of the things that people say is the digestive distress. And I'm like, okay, what is that?

That's a big umbrella statement. What does that mean? Because what I noticed myself, when I'm eating way less, I tend to gravitate towards whole foods even more so. I want something nutritious. Now that might be because I know and I'm very aware because how long I've been training and dieting. And so I'm like, man, my body is craving this.

What I think is happening is some of these people that have terrible habits and have had it for so many decades and they just eat way less. They just eat way less of the shitty food. And so then of course that backs them up or of course it gives them diarrhea because like if you're barely eating any food to start with, then you get reduce it

even more dramatically and then you don't even attempt to make healthier choices than I would imagine. That's probably where a lot of this digestive distress reporting is coming from is more so that than actually the GLP-1 doing something. I know it slows down the digestive process, but I think it's more of that than it is really the GLP-1. Would you agree?

Is that something that you see? For sure. And also what nobody's talking about is that folks who suffer with type 2 diabetes have vagal nerve dysfunction. So they're already headed towards gastroparesis in some capacity. Most of them are sitting in some version of it and they're just having dyspepsia. Like they're burping and having reflux and the doc's like, here's some pepsid. And I'm like, no, you're getting gastroparesis, low-grade. Like your vagus

nerve is being destroyed. And then on top of it, the number one cause of pancreatitis is throwing a gallstone into the pancreas. So these folks are already sitting with sludgy gallbladders and inflamed gallbladders. And the other main cause of pancreatitis is fatty pancreas. It's like fatty liver. No one talks about it. So folks that are using it predominantly are in the categories of those who are type 2 diabetics and or obese. And so they're already sitting with all of these horrific things waiting to happen, brewing. They also have a higher propensity towards thyroid cancer, which has been completely dispelled. There is no risk of thyroid cancer in humans.

The data is very clear on that. But anyway, all of these gastrointestinal issues these folks are having, they're already having it. And then they get slammed with this big dose. With a huge dose, slows down gastro-guemtein. And they're eating, they're crushing high-fat foods and things that are- Instead of eating a box of Oreos,

they have six Oreos now instead, that's it. Right, and a cheeseburger from, you know, whatever, like not a good grass-fed, you know, and it's a mess, and then it's just like you take a hot mess of, and no disrespect, this is how I talk to my patients, I'm like, if you're a hot mess of health, and we put something on top of this that's gonna make a bigger hot mess, then it's just throwing lighter fluid on the fire.

Yeah. I want to go back to the neurogenesis effects, like potentially, and just has there been any like in your own practice, have you been working with athletes at all that have had head trauma? Is there any kind of studies out there in terms of like being able to treat any kind of like severe concussion, like protocols, like, is there anything in that regard? Ooh.

I feel like I'm in a movie theater. That was all the power coming out of that question. I don't, I haven't seen any data specifically around that, but my husband has been knocked in the head repeatedly. And I do think that that's a piece of his high blood pressure. And so that's, and I had, I was a gymnast, I had a lot of head trauma. So that is very specifically a reason I would use it on anybody.

Yeah. I mean, this is a personal question because it's very close to me. And the only, the only thing I've seen so far with treatment wise has been like microdosing psilocybin. Right. And so I was just curious about that as maybe a potential future direction. You know, you could go with it. Well, you bring up a really good point because I often get asked,

who is the best candidate for this peptide? And I'm like, anyone who needs any of these things, anyone who needs, anyone who's had significant amounts of head trauma, anyone who needs, anyone who's had significant amounts of head trauma, anyone who has cardiovascular compromise, anyone who has depression or who, whatever the reasons are, but it also is effective going back to the GI stuff, I'm seeing it reverse people's, you know, SIBO, like everyone says,

oh, well, if you have SIBO, if you have small intestinal bacterial overgrowth and then you slow down the gastrointestinal track. That should make it worse. Yeah. But I think that a lot of these people's SIBO is being driven by a dysfunctional immune system and inflammation. I mean, it blew me away at what I did for my psoriasis. I've done everything. Yes.

I've tried every diet. So you have the same. And we did tons of stem cells. I did everything. And the, this is, I, my psoriasis has never been this good. And I'm just so that was not... He thought it was that he was eating less. Yeah.

I saw it's fascinating to me. That was even the intent of this. Like I'd already addressed all that stuff and I've been trying to get that down for a very long time and nothing has helped as much as simply doing this. So, so here's my, here's my fear around this. Cause anytime, um, you see a medical intervention that has this, cause this, this has tremendous potential to really shift and impact culture.

I mean, it makes me think of other culture, impacting interventions like birth control or antibiotics or opiates and amazing things, but also over-prescribed, all these other issues that we didn't, you know, predict. My fear is that they're going to put people on these, they're going to have them lose weight 40% of the way it's going to be muscle. And a lot of health issues are not due to obesity.

A lot of people's health issues are due to the fact that they're under-muscled, even obese people. I remember years ago when they came out with some scans on obese individuals and the old myth was, well, if you're obese, you have more muscle mass. And they came back and said, no, they don't. Sarcopenia is more common in obese individuals. So that's my fear. My fear is we're going to put a bunch of people on this who are obese.

They're going to lose weight, but are we trading one for the other? Which really makes me feel very responsible to communicate this the right way. So when you work with your patients, is it just, here's your GLP-1? Or are you like, no, you lift weights? Yeah. Okay. Let's talk about that. Talk about all the other stuff because just cutting your food intake down, you might lose

body fat, but then you lose muscle. I think I was texting you this. Like 20% of people with heart disease and diabetes aren't even overweight. It's like a significant minority of, that's still millions of people. So that's not the only issue is just obesity. Right. I think it's already happened. I think that's why people are having, we're seeing such pushback on it is because I'm getting messages from people all over the world saying, you know, my father wasted away from this or my, all my work associates are just eating donuts and

drinking diet coke still, and they're wasting away and everyone looks like a ghost. And so those folks are going to be so metabolically destroyed at the end of that journey. And then their insurance runs out or stops covering it after a certain amount of time. And now their skin and bones, they've lost all their muscle. They've done nothing to

reestablish their metabolic health. It's a disaster and it's happening in real time. I think the damage is already done. I think that's why everybody's freaking out about these and that's what they're seeing. And so they're coming at me hard online saying, this happened to my uncle or this happened to my daughter and how dare you promote these drugs? And I'm like, oh, this is bad. And this is what's happening when, but you know, most doctors, no disrespect to my colleagues, but most doctors don't know

what the F they're doing when it comes to metabolic health. They don't lift. They talk about it on their Instagram, but I'm like, dude, like you don't know, you don't deadlift, you don't do anything, you know, and it's just like cool to talk about it. Now I know I'm not like ripped or anything, but I lift and I lift regularly and I'm just skinny. That's the way it is. I'm not like ripped or anything, but I lift and I lift regularly and I'm just skinny I'm just trying to keep my pain down but I don't think most doctors have any clue how to address metabolic health and And I know at least my colleagues had no idea even in the holistic space Well, when you know that debate I was the one part of it that we I was screaming at the radio

Was the when he made the point that people needed that they don't realize they need to train five days intensely. Intensive strength training. I'm like, you shouldn't do that in a calorie surplus, much less in a, that much of a, like that's crazy. So we're definitely seeing, uh, even the doctors that are, it sounds like even talking about lifting weights, the over-application of, of intensity. Oh, he was, I thought he was. No, it's interesting that I was debating a non-doctor, but he's not a doctor.

Has no health credential. Like he's not. Well, you could tell he doesn't work with anybody. He's never, he was a, he worked with big pharma. That's where he used to work. He doesn't work with clients. He's not a health professional. Oh wow.

I thought he was. He used to work for big food. Cause here's my fears. My fears is one side, which I just said, you go on a GOP one, eat less, don't do anything else. Lost weight, yay, we're happy, but uh-oh, we're losing muscle. The other fear I have is people are like,

oh, I heard I'm going to lose muscle. Let me go beat the crap out of myself in the gym now that I'm on GOP-1, and if you overtrain and you're in a calorie deficit, you're going to make things even worse. That's a disaster. And the average person who's deconditioned will overtrain with more than a couple days

of strength training properly. Their body just can't handle it. So those are my two fears. So how do you communicate to your patients? Like what is, this is a piece of, I'm assuming a, you know, a prescription or a repertoire or a program that you put together for your people. What does that typically look like? People who don't work out at all tend to want to start moving at a certain point. Like, something exciting happens when they take the GLP-1. Their brain starts to feel better and they want to start moving, right? You feel better, you do better.

And so I encourage people to just move straight away. Like, just start walking. Just move every day. Move. I don't care how you do it, what you're doing. We don't have to strength train right now because, you know, my dad is not going to strength train. But my dad, after 10 years don't care how you do it, what you're doing. We don't have to strength train right now because my dad is not gonna strength train. But my dad, after 10 years of basically turning into his lazy boy chair, was telling me the other day, I can't wait to go walking again when the spring comes,

when the sun comes out. We're just getting the sun in Oregon this week. So he's excited to go walking again. So this has been, he's been on it for months. My mom's been on it and she's a tiny little thing. I don't want her wasting away by any means. We have to protect every ounce of muscle she has, but the minute the garden starts going, she's out there.

So whatever it is that somebody wants to do for someone else, like my husband, I'm like, dude, why, you know, are you going to the gym? Are you going to the gym? Are you going? That's the constant, like, are you going to the gym? And he is. So it's a matter of protecting the muscle, making sure they prioritize their protein. There's only so much room you have in your stomach in the day, right? So making sure what you put in there first is not the carbs and the

whatever, the refined, we shouldn't be eating. I actually found that part, I told the guys, really easy if you're just paying attention and you're aware. Because I even tested kind of eating outside of that. Well, what happens if I eat this, if I go out to eat and have these fried tacos or something different? Like, I mean, I'm destroyed right afterwards. And so it was really easy.

So I feel like if you're coaching someone, you're actually communicating with the client, like if we were helping someone through it, it'd be very easy to help attach that. Listen, notice the difference when you have that ground bison with sweet potato versus when you have that cheeseburger when you eat out. I found it actually really easy to train myself to crave and go after the healthier foods. I think it's just the lack of the communication or coaching these people that just don't know any better and just assume that it's the GLP ones that are making them feel awful. It's like, well, no, it's become even more important that you go after whole foods and protein.

Yeah. So prioritize the nutrient dense foods and start moving. And then around month three, that seems to be when the weight starts falling off for people. It gets really exciting around month two and a half, three. People start to see profound changes happen. That's also, I find, when it can sneak up on you. I don't know what your experience was, but for myself and for others that I've worked with, it was around that point where I think a lot of tissue saturation was happening,

and suddenly the dose they were on was a little too much. Like, it was fine, and then it wasn't fine. So we had to back it down a little bit. These are all very, you know, fairly metabolically healthy people. Not like you guys, not like us that are hitting the gym, but you know, even my mom, my mom's a sturdy gal for someone in her seventies, like no meds, doing great. And so that's when they start really feeling good. I'm like, all right, let's hire a coach or buy a program, or make sure you start prioritizing muscle strengthening, because strength is more

important than muscle mass. That's the other piece that no one's talking about. Even if people are losing 40% of their, here's the thing, they're not losing 40% of their muscle. 40% of the weight they lost is muscle in the worst case scenarios. And also something that, um, there's a pharmacist I've been talking to, Dr.

Leonard Pastrana. He's part of the Seeds Institute. Okay. He's a real super smart guy. He talks about cellular hydration. If you're dehydrated, these can induce, they, these do keep you from drinking or remembering to drink water.

I will say that. That's the other thing I had to train myself. Yeah. You have to remember to drink water. I will say that. That's the other thing I had to train myself. Yeah. You have to remember to consume hydration. And his argument is a dehydrated muscle will be lower in mass. Of course. So they're not taking that into consideration. These aren't dry muscle mass measurements.

This is just. Yeah. This is like overall. So perhaps a lot of this is dehydration. And then my argument is a lot of pathologic muscle in the type 2 diabetic or the metabolically busted is fatty infiltrate and I believe that these take care of fatty infiltrate really well. We see that with fatty liver. It takes, it does a number on fatty liver fat, the fat that's infiltrated in the liver and so it must be happening the same in the muscle.

So folks are losing mass by weight but a lot of it's probably water or hydration and fat. The marbles. Especially if you drop your carbohydrates. If you're eating less carbohydrates, you're going to store less water, less glycogen in the muscle. And then strength is really much more important to me. So as long as the person, I don't care if the muscle mass

reading looks lower, as long as their strength is being maintained. The minute they say, I'm starting to feel weak, I'm like, we gotta lower the person, I don't care if the muscle mass reading looks lower, as long as their strength is being maintained. The minute they say, I'm starting to feel weak, I'm like, we got to lower the dose and you have to start strength training more regularly. When you look at the studies on muscle and its health effects, really what you're, it's a proxy for strength because you can have more muscle mass, but the muscle not be as healthy as metabolically active. And the best way to measure that is through strength. So when we communicate muscle,

we just communicate muscle because it's aesthetic. People like to hear that, whatever. But really what the data shows is how strong you are. Can you get up off the floor without holding a thing? Can you, you know, grip strength test? That's a good proxy for overall strength. Can you, yeah. And it's really not about the muscle mass,

although muscle mass is strongly correlated with strength. It's really about the strength that's more important. And then there is Dr. Gabrielle Lyon talks about this, how there's muscles, not muscle. I mean, you could look at a bicep from someone who's unhealthy to someone who's healthy and they look and act different when you look at them under a microscope. So, so you think some of this is water, fluid and fat? Fat. Fatty infiltrate, yeah.

That marbled diabetic muscle that's really pathologic. That's why people break their hips. They've got marbled, metabolically dysfunctional muscle, that sarcopenic obesity picture and as they age age it's just a disaster. Are you looking looking the future do you think that this would be something that people should go on change your behaviors work in their lifestyle go off or go on a lower dose cycle on and off or is it dependent on the individual? I think it depends on the person and again what are we going for like if you

were using it for neuroinflammation, that might be a lifelong endeavor, especially as we age, we get more neuroinflammation. That's just part of the aging process. So there's a longevity piece to this and it depends. I'm not going to go off of it. I'm going to cycle it. I'm going to rotate it. I might, you know, when I do testosterone,

I actually cycle testosterone. So I'll do testosterone two to three times a year. I don't stay on it forever, you know. I don't even stay on my progesterone forever. I cycle everything. I even cycle my thyroid and I will go into a very low-grade hypothyroid place and then come back just because I'm trying to resensitize my receptors.

So I never just crank hormone all the time, you know. I just don't think that's a good idea. So I think it depends on what the individual's needs are, what their short-term goals, what their short-term goals, what their long-term goals are. Some people might want to go after weight loss initially. Like I said, people get down to their fight and weight, but then we got to find the dose where they're not losing any more weight, but they are having the impacts they're looking

for. Maybe it's depression, maybe it's acne, maybe it's any of these skin issues we're treating or whatever it may be. There's fertility improvement with them. We're having the ozempic babies we're hearing about because you take care of the metabolic dysfunction and people get pregnant. Dr. Justin Marchegiani Is supplementation much more important with people? Because of the reduced calories, reduced nutrients, do you like to supplement with things like essential amino acids or anti-cata-ketabolic nutrients like HMB and then what about a multivitamin? Are these like

staples in your practice with? I'm not a big fan of multivitamins but I predominantly my followers are my age and older so we're always combating catabolic. I mean once you hit 50 it's like and you're a woman you know we're always just trying to not break a hip. So it's always, I'm always trying to put on muscle. I'm always trying to build. And if I don't actively pursue that through diet, nutrition, supplements, etc., then so I am a big proponent of essential amino acids and, you know, whey protein powder. I'm a, I, you know, I love the, I love the idea of eating our protein and chewing it up because that does great things for our jaw health and it does great things for the muscle protein synthesis.

But I'm not opposed to putting a couple scoops of whey protein powder in my day just to make sure I hit my protein macros. Better that than you'd be under by 40 or 50 grams, right? Yeah. Yeah. So whatever, you know, I'm mainly dealing with ladies who are just, you know, we're just trying to stay hot and happy and not break a hip. Are you finding, are you finding, cause you're out here communicating the microdosing

and that we were probably over applying it to a lot of people, that patients are able to go back to the doctors and communicate them and they're lowering their dose? Or is that only through the people you're working with? Have you heard anybody having, cause I know, isn't Ozempic already like a preloaded pen? Yeah, this is a challenge. This has been a real challenge for people. I have a program where I teach them how to, first of all, I educate them so they can go have those informed discussions with

their doctors because really it depends. Some folks can use those pre-filled pens at the lowest dose, they come in and they're just fine. Maybe they have enough metabolic dysfunction or enough deficiency that that 0.25 milligrams isn't too much for them. But I'm finding, you know, a lot of people need to start much, much lower. And so that only is available through compounding. And that means finding a doctor who's either versed on this, willing and open to doing it. Most of those are not your...

Something we haven't discussed is the FDA is really, for some weird reason, has really, and I'm assuming it might be, as my guess is that there might be some big pharma influence here, they're really coming down on these compounded merchants. So every time I open any of my medical newsletters, there's always some clickbaity article like compounded samaclutides dangerous, don't prescribe it.

And so doctors in the traditional system are vehemently against it and it's very weird. But anyway, finding a longevity doc, finding somebody who can... Let's pause there for a second because I want to be very clear on this. So a compounding pharmacy is an FDA regulated pharmacy. They're not, I don't believe that they're FDA

regulated. I think that's the problem. They have to abide by best practices. And so they're not, you know, it's not good business for them to make something that's contaminated or dangerous. But they also make pharmaceuticals. They do.

And so if there is a shortage or if there is a, so there's a shortage of GLP-1, I'm sorry, Ozempic, of the brand name ones. I understood this and I'm not totally sure I'm right on this, but I have understood this to be that there was a shortage in the pens and the dispensing pens. There's plenty of semaclutide compounded to go around, but because of the shortage, compounding pharmacies are available, are open and able to dispense this. They wouldn't be otherwise. But because they also put out pharmaceuticals,

which are FDA regulated, if they do anything wrong, they could get pulled. So the point is they have a very strong incentive for doing things right. Getting a, what does that say up there, Doug? No, it's not approved by FDA. Okay. So getting a compound like semi-glutide or terzepatide, it's essentially the generic form

of the same, of Ozempic. In other words, like ibuprofen versus Advil, right? I think it may be chemically a little different. Okay. I'm not a pharmacist, so I don't know. And I've talked to my pharmacist friends and I think it may be chemically a little different. I'm not a pharmacist so I don't know and I've talked to my pharmacist friends and I think it's something about being a salt-based versus a different version so I don't know if it's exactly the same. Something we didn't talk about was that samaclutide, I mean just going back to the very beginning of the conversation, samaclutide is

bioidentical to the GLP-1 in our body. I mean, it's almost identical except for they tweak some amino acids in there. Just for a longer what, half life or something? For a longer half life. So it's really where, when people say it's a drug, I'm like, no, literally it's a bioidentical hormone. Like exactly, it just has a longer half life in the body. And the cost of getting it through a compound pharmacy is way less.

Way less. I mean, you're going to spend a thousand dollars or more a month on some of these brand name ones. The compounded version is way, way less expensive. Did. I mean, you're going to spend a thousand dollars or more a month on some of these brand name ones. The compounded version is way, way less expensive. Did you see what happened? I think it was this week. I think the FDA sent a letter to the makers of Ozempic because a study came out last month

showing that it only cost them like $5 to manufacture it. Wow. And it's only like 60 bucks in Germany for a month's supply and it's only like 150 bucks in Canada. a month's supply. And it's only like 150 bucks in Canada. And so I think they just got a letter saying they're going to force them to, I'm not sure, I didn't read the letter, but I saw something on it that they're trying to force them to make it generic so that it's more readily available.

Well, this is also a bigger problem because a lot of these pharmaceutical companies make up the difference in the U S so they'll, they'll sell their pharmaceuticals for much lower prices in other countries, but then to make up the difference in the US. So they'll sell their pharmaceuticals for much lower prices in other countries, but then to make up the difference because of the R and D and going through the FDA process, it's like a billion dollars to get something from conception to market. They make up the difference by charging people here a ton.

So that's why you see the discrepancy, 60 bucks over there, 1200 bucks over here. Interesting. It's a very broken system. And something else, this is just my speculation. I couldn't figure out why the smear campaign was so big against these. Why everybody all of a sudden in unison

after these were on the market, you know, like I said. We had guesses. Well, there's different, yeah, right? There's different versions of it that have been out for 20 years. But the second the conversation turned to weight loss, everybody lost their minds. And that's a whole thing we could talk about.

But I started thinking who's got money to lose here? Obviously the snack food companies, the dialysis companies are concerned. Type two diabetes is a very profitable industry. I mean, it's very profitable. It's one of the most profitable. Um, the joint replacement companies are concerned because all the boomers need hips and new hips

and knees and everyone coming down the chute is probably looking if this obesity epidemic keeps going. But then I started thinking what, I started looking what pharmaceutical, big pharma companies do not have a GLP-1 as part of their repertoire. And you know, Pfizer's just got rejected.

So that's interesting. They had one, they probably spent billions to get it to market and it got. It's okay. They made a lot of money a couple years ago. So I'm just, I'm like, my theory is that if somebody is having cardiovascular regeneration and, you know, all these other regenerative properties, would they need these lifelong drugs?

Nobody seems to have any problem that they're on, they're mad they're mad their aunt's taking ozempic, but their uncle's on a life of Lipitor and high blood pressure meds. That's okay. You can stay on your lifestyle medications. So I got to thinking, what if you don't need these medications anymore because this might be healing up all these systems and then there's no need for these. What big pharma companies might have something to lose there? I don't know.

I'm totally. It has the potential. This is one of the reasons why I say this is cold. I feel like we're going to look back in 20 years and go, oh, there was before the GOP ones went mainstream and then after type of deal. But then there's a lot of pharmaceuticals that are used to mitigate symptoms of obesity and poor metabolic health.

Yeah. A lot. So if you solve that, even just through weight loss, then yeah. And then the snack food companies, Walmart reported their snack food sales have gone down. The companies are meeting together and saying, how do we need to figure this out? Because people are not buying our, they're already noticing a dip in sales. Those are their best customers. They're best, they're losing their best customers. Now, on the other hand, you also have potential for making a lot of money.

So I think that these pharmaceutical companies, while they're fighting it, are also dumping, I think you're going to see a whole bunch of R&D into GLP-1 type. It's good. We're going to see a massive propaganda war on both sides, I think. That's why it's going to be really, which is again, why we did all this. We're trying to talk about it because I think, and we see it within the coaching and trainer space, there's definitely a division. There's a lot of people that are either,

you're all pro it and then just do it to prescribe it, it's changing lives, or the other side of just like, oh my God, this is awful, it's the worst thing ever, it's gonna hurt us. And so I think it's here to stay forever and I think it's our responsibility to get educated on as much as possible and to learn how to work with it because it can be life changing for somebody for sure. I think it's going to fuel the already growing interest and understanding of strength training,

that's what I think. I think so too. That's actually why I started. My strength and conditioning coach, he trains middle-aged women and I came to him and I said, I've been on this like total nerd out research rabbit hole about GOP1 agonist. Do you have any clients taking them? And he said, actually, and he told me about three different types of women, three totally different women. One woman was in her 80s. She's been training with him for years. She shows up religiously and does her workouts. She had been quite obese and had lost quite a bit of weight and was feeling

phenomenal and has been on them for some time now. He had another woman who was, I think, postpartum and, you know, just kind of carrying around that 30 to 40 pounds. She just couldn't shake after a couple of babies and really wanted it off. Got it off, looks phenomenal. She's in her twenties or thirties and, you know, really feeling young and sexy again. And then he had a woman exactly like me. He's like, she's good looking, middle-aged woman, healthy fit, been training for 10 years or more.

And then he watched me. He's been training me for 10 years. He watched me thicken up, you know? And he said, she just takes the smallest dose and she lost that 10 pounds, she looks great. I said, has anyone lost any strength? He said, of course not, I don't let them. And that was it.

I was like, I'm doing it, I'm taking it. He was the reason I was convinced because he was, he's like, I would be stupid. He said this, he's like, I would be stupid, he said this, he's like, I would be stupid to poo poo these. My people are gonna be on them. My clients are gonna be on them. It behooves me to learn as much as I can and be open.

This isn't a, I think people, there's really this turf war, like well, it's scarcity mentality. If they have this, then they won't need me, and I'm like, no, they'll absolutely need you. They'll need more of you. Yes, more of that. And then the other piece is the people poo-pooing on it are, in my opinion, maybe doing the work of Big Pharma.

They're like, oh, it's Big Pharma, it's evil. I'm like, maybe if Big Pharma is part of the smear campaign, you might be participating in the whole, I don't know. I had that exact thought because if you put obesity at the top or poor metabolic health at the top, and then you list all the medications that are used to mitigate the symptoms of that, it's like an endless list of medications. And if you just solve the top part, you would wipe them all out. So what you're saying makes a lot of sense as to why people would be a little scared. And there's data showing really positive impacts on Parkinson's and

Alzheimer's, which is like end game of, I mean, if you don't die from all the other things that metabolic dysfunction causes, you will end up with dementia, so like, or on dialysis. So like if it's healing kidneys, the kidney study on kidney failure had to be stopped because it was so effective that it was unethical to deprive the control group of it.

So the dialysis clinic's popping up on every corner. Yeah, that just happened in October. And then the, you know, end game of like Alzheimer's and dementia and Parkinson's, if these are that impactful. And then I post about it on social media and people cannot, I won't even mention the word weight loss. I'll just show them the Alzheimer's study. And they're like, only lazy people need this. This is, you know, people don't need to lose weight with this. And I'm like, dude, I show them the Alzheimer's study. And they're like, only lazy people need this.

This is, you know, people don't need to lose weight with this. And I'm like, dude, I'm talking about Alzheimer's. Like you better hope your grandma doesn't get it. If you're this vehemently against it. Cause I'm putting my grandma on it. If she needs it. You know, what's interesting, Dr. Tina is I used to think that way as an early trainer.

I used to think, oh, people are just lazy and disciplined. It's just too many, too many calories, not enough movement. But there's more to the story. I just pulled up, we had a friend of ours post a Dr. No, it was Drew, Drew Canole. Shared some data showing from 1999 to now, our overall caloric intake actually hasn't gone up. And yet there's a 30% increase in obesity.

So I saw that and I'm like, this can't be right. So I looked it up. There are multiple studies that show this. In fact, the trend actually is going down in caloric intake just slightly. So people are eating the same or a little bit less, yet we're more obese. There's something else going on. And I don't know, call it what you want, environmental factors, you know, estrogens, chemicals, not enough muscle, maybe all of those. Yeah, totally above. So there's something else that seems to be gone awry here

and it could be all those things. I mean, what's your theory around that? Because when I saw that, I went, my initial thought was, okay, people are under-muscled. I said, but there's gotta be more to it than just that. I think that's a big piece, but I think there's more. I think it is generational. Do you guys, have you ever heard of Pottinger's cats?

Yeah. Explain it though. Were Pottinger's cats. Pottinger was a veterinarian and he was doing research in the thirties, the same time that Weston Price was going around the world, looking at everybody's dentition and the adaption of the Western diet at that time, which was pretty damn good, you know, comparatively. And Pottinger found that when he fed cats, cooked meat and pasteurized milk,

that they very quickly became infertile within. Like one generation. Couple. Yeah. And their livers got fatty and their intestines got boggy and they're, you know, they basically turned into what we're seeing with the modern human and it was very difficult once he put them

back on their traditional diet of raw meat and unpasteurized milk. It took a couple of generations. It took many generations. So we are pottinger, I am like the first generation, I think of pottinger's cats. And so people want to say, oh, we just, with, you know, we shouldn't give these to children. And I'm not saying give children anything before

we implement lifestyle, but that's a complicated conversation because the parents have to be involved and a lot of childhood obesity is due to parental obesity and it's not a judgment, it's just what it is. The other piece that nobody wants to talk about is that maternally gestational nutrition and obesity status and metabolic status epigenetically flags the offspring.

Yeah. And so the offspring, the children of mothers who are obese and diabetic are significantly set up for a life of, yeah, it's kind of like they don't have a chance. And we're a few generations into that now. We're not just one. So I think as a species, we're in a lot of trouble because we've got these genetic issues, these, I'm not saying all obesity is genetic, but there is a genetic component for various

reasons, like what does their leptin signaling look like, what's going on in their brain, you know, there's reasons. And then these epigenetic flags on top of it. And I just had Lily Nichols on my podcast. She's a diabetes, she's a prenatal diabetes metabolic specialist, and she was just, the stats were sobering.

It's pretty bad. Like. Yeah. The, the data on having, on like, like a mother who's under a lot of stress, uh, the child tends to be more vigilant because their body's primed for this environment. It makes perfect sense.

Evolutionarily speaking, right? Yeah. The baby's going to be primed for the environment that it's going to be, uh, move into. So if the environment says capture these calories or be hypervigilant, um, then, then the epigenetic, uh, signaling is going to say, here, express your genes in this way. So it makes perfect sense.

And these kids are, I mean, it's heartbreaking. You know, back when I was growing up, there was like one kid in school who was overweight and they usually had a true glandular issue of some sort. And no 12 year old, 10 year old, nine year old kid wants to be morbidly obese. Do you remember when type two diabetes was called adult onset? Yeah.

Yeah. It's just, it's like, it hurts my, I mean, it, like, it makes me want to cry when I start thinking about, I can't even get through some of the data that I read. I'm just like, oh my gosh, this is so sad and heartbreaking. And if there's a tool and we could use it appropriately in these young people,

along obviously lifestyle, that's what we've been talking about. Like that's non-negotiable. The strength training part, the lifestyle component, that's non-negotiable. But when you look at what is necessary to right the ship for a young, obese person, it's like really involved for them, for their family, there's a lot of counseling that needs to go on. It's. Do you mind if I speculate on that a little bit?

Because when I think of that, um, part of me is like, okay, I don't know if we should signal a receptor on a developing brain. There's parts of the brain that aren't fully developed until you're in your like mid twenties and it could theoretically, right? You hit a receptor, it changes the way the brain shapes. We don't know what that necessarily means, but then on the hopeful side, I know this as a trainer. Okay.

When I trained mom and dad and they got fit and healthy, the kid got fit and healthy always, because it was the parents that controlled the environment, it was the parents that bought the food. It was, yes. So I hope we don't go the direction or need to go the direction of medicating kids, but rather, hey, let's get the parents on board.

And then we have this downstream effects, these health effects. So that's the hope that I would have because the other side is like, I don't know how we would know, how are we affecting, I mean, we're giving kids all kinds of stuff all the time. And how is that changing how their brain develops? I don't disagree, but I also know that there

are kids who are hypothyroid and are not diagnosed for years. Like I was one of them and suffering with severe depression and severe health issues as a child when all it was, was like, I just needed a little thyroid and the doctor wouldn't give it to me. Or the doctor didn't notice it or see it. We don't have a test for GLP-1 deficiency.

No, there's not a good test at all. And so I really do wonder, there are people in my life and in my family that I, I wonder, I'm like, I wonder if there was a GLP-1 deficiency happening when they were a child. And it's just been a lifelong struggle for them with their weight, with their mood, with, you know, there are all kinds of things. So for me, it's like, I don't, I don't have an answer. I just am speculating, but I do think if a child needs a little something, something, a lot of kids get missed in this system. Maybe they have a slight growth hormone deficiency or a slight thyroid issue, just a slight deficiency. And applying the right hormone at the right

time by an astute physician can just be life-changing for that person. And really, again, going back to the fertility issue, I mean, we are dealing with an infertility. We're going extinct as a species. Oh yeah. Nobody talks about that. So I just, that's the part where I'm like, I

don't want to completely pull the GLP-1 conversation away from the kids. Maybe they need a little something. I don't know. I'm not a pediatrician. I don't manage kids. It's something that's in my head that I feel like I don't want that to get missed.

Well, one thing is for sure, I know you've seen this before. You ever look at the amount of new chemicals that we're exposed to today versus just 10 years ago versus 20 years ago. And we test these chemicals by themselves and we test them in a 12 week, 18 week trial, but we've never tested 200 chemicals all at once and we're all exposed to them all the time. And it's very different today than it was. And I mean, come on, I don't think I need to make this argument. You mentioned obesity was rare when you were a kid.

I don't remember kids with food allergies. Right. Or chronic asthma. No, my kids go to school and there's tables, allergen-free tables so that all the kids with all the crazy food allergies have to go. And it's like so common that you can't bring a peanut butter sandwich to school in some schools because of that.

So, yeah, something's going on. Something's happening. I was watching TV. I never watched TV, like actual real TV. Like I might watch a show on a network or something. And we were in the hotel room and we were watching TV and every other commercial was a pharmaceutical commercial and it was all for autoimmune conditions. It was all skin and autoimmune.

It was, well, skin, you know, eczema and psoriasis are autoimmune. It was all autoimmune conditions. It was all skin and autoimmune. It was, well, skin, you know, eczema and psoriasis are autoimmune. It was all autoimmune conditions. And I was like, oh my God, this is obviously the prevailing problem. And I haven't watched TV in so long. I, you know, I had no idea what they're advertising. And then I looked at my husband and I was

like, isn't it crazy? What if we just gave everybody microdoses of who have autoimmune disease, GLP-1s to reverse that, because the side1s to reverse that? Because the side effects on those drugs that they were advertising were horrific. Oh, terrible. And I was like, I wonder if, you know, and I'm being,

I'm being campy and I don't mean this literally, but like, I wonder if, you know, Ozempic wouldn't just solve the autoimmune crisis to some degree. And like you said, it gives you that control back of what you're eating. And so you make the better food choices, which means you're going to choose the more anti the better food choices, which means you're gonna choose the more anti-inflammatory foods inherently.

So you will be reversing your autoimmune disease versus like death, lymphoma, all these horrible side effects from these, you know, immunodulated drugs. I know I was like, we are so off course here, you know? 75% of our advertising money. That's why this is scary to me too. It's just like, it's gonna disrupt so many other spaces. And we're talking about food and stuff like that, but you know that 75% of all

advertising money is pharmaceutical drugs. 75%. Well, and all those commercials were for auto immune disease, whether it was rheumatoid arthritis, psoriatic arthritis. I was like, I didn't know this many people had this. I've seen like 15 different psorias ones, like it's created just like the last like year. You know, it's funny about that by the way, the consumer, the consumer can't go to the store and go buy these drugs. So who are they advertising for? Well, they're advertising because they control the networks. They can control the narrative.

That's why they're spending. It's really crazy when you, when you break it down and think about it. It's a vial. Yeah. So how important is it that a person using these works with someone who really understands how to work with them, really understands lifestyle, really understands what's going on, how to dose appropriately. I mean, how important do you think that is, your personal opinion?

Well, again, I think that some folks are so metabolically busted that a small dose of the standard, if they can access the regular pharmaceutical version. And so I've got people in my program who, after, you know, I gave them some, some guidelines, they went to their doctor and they were like, Hey, here's the data. I want to try this. They were put on the, the, you know, first dosage, the lowest dosage, which is 0.25 milligrams that

comes in the pre-filled pens and they're doing fine. They're doing great. And so I think as long as folks are continuing to educate themselves, I mean, that's the whole premise behind the work I'm trying to do is really educate people. I've been accused of being a big pharma shill and I

was like, that's funny because I'm pretty sure big pharma was behind silencing me these past few years. So no, like you don't know where I've, what I've been doing obviously, but not you guys, but you know, the people coming at me. Um, I just think done right. This could be so disruptive in such a good way.

And I think that if people are educated, they can go in and have conversations as long as they're working with doctors. I mean, if you have a doctor who's not going to listen to you, get a new doctor anyway. Period. Period, right? Like, you have to be proactive. You have to be educated as a patient.

We are the only ones who are going to get ourselves through any health crisis. Like, you have to be proactive and educated as a patient. And so finding a doctor who's going to listen to you and work with you, even if it's in the conventional model and you're using the conventional brand name and that's the way it's got to go for now, I think that that can be really impactful for people as well. But they have to listen to what we're saying here, which is strength train, get on a, this is non-negotiable. I mean, I always say that strength training is non-negotiable. It's non-negotiable whether you're on a GLP-1 or not. If you don't want to succumb to the horrific end game of metabolic dysfunction, which we

all are going to become more metabolically busted as we age. That's just, it's called inflammation. It's part of aging. We will become more insulin resistant. We will become more metabolically busted as we age. No matter what, I was living it, I was feeling it. So unless you're actively combating that, starting in your 30s hopefully, at least in your 40s,

but you can do it at any time. And you probably know the data better than I. Old folks in their 70s and 80s, they can still put muscle on. Oh, tremendous muscle. Yes. Yeah, they build incredible strength in muscle. You never lose the ability to build strength. Your ultimate potential changes, but, and you

know what I love about aging, this is what I love the most as I'm getting older. And I noticed with my clients when I, when I was a, when I used to train people, the difference between you and your peers just gets bigger as you continue to work out. Like when I was in my twenties working out and I'd hang out with my buddies, I know I'm more fit,

but not that big of a difference. Yeah. At 45, I hang out with my buddies where 45 don't exercise. It's like, we're not the same species. Like you guys are already on meds and you already got back pain. You can't play with your kids. And I'm over here working out and having a great time. So it makes a huge difference.

It is the fountain of youth if that ever did exist. And there's studies showing that you have better collagen, your skin looks better. Like it's, you just not, it's nonnegotiable. Besides we don't want to break a hip. If you break a hip, it's the kiss of death. That's the end. You die in a hospital of pneumonia with a

broken hip, like I'm not going out that way. I don't know the first time I heard that. I used to train a bunch of doctors and one of them told me, oh yeah, break a hip, die of pneumonia and I went, oh my God, I never heard that before, but I'd seen it before. Horrible. And even if they live, I've seen so many

patients go through this. Cause I inherited all of my mentors' patients. So he'd been taking care of them since he was in his twenties and I inherited all of them. So I had patients in their eighties, nineties, like just had, it was a legacy that I got to carry on and they would break a hip and they were, they just never came back the same.

If they survived it, they never came back the same. It was just like this slow, horrible descent and the dementia and the, all of it, just, it was so bad and so sad. And so that's why I started strength training. Honestly, I was 40 when I picked up my first set of weights. I was like, I went in and I was really skinny and I told my coach, I was like, I want to learn how to deadlift. And he goes, well, let's take you through the body composition. I'm like, dude, I went in and I was really skinny and I told my coach, I was like, I wanna learn how to deadlift. And he goes, well, let's take you through the body composition.

I'm like, dude, I'm skin and bones. I just need an ass. I just need to build an ass because my back hurts and I don't wanna break a hip. And he was like, okay. So that's been it. Perfect client, I love her. That is literally been it for 10 years for me.

It's like, I'm 50 now, I just turned 50 and I'm still just trying to build an ass and not break a hip like that. That's great. You've referenced your mentor as like a Jedi, looking back now at the stuff that you learned from him, were there things that he was just like so far ahead of his time,

like now that we see that we're applying now, or like what are some of the things that you were like, wow, I didn't realize how far ahead he was? Oh, you're making me cry. He was so great. Well, first of all, he was gorgeous and he just was always fit. And he told me way back in the,

I got out of college in 95 and I went to work for him as his receptionist and he was like, stop doing cardio. It's overrated, go lift weights. You have to lift weights. This was a doctor in 95? Wow. See that crazy? Nobody was saying that back then. He was just a silver haired fox.

And he, I was like, well, he's hot, I'll listen to him. I mean, and not in like a sexual way. He was just a silver haired fox. And he, I was like, well, he's hot. I'll listen to him. I mean, and not in like a sexual way. He just was a good looking older guy. And I was like, I always listen to good looking older people. Like anyone who's good looking, I'm like, whatever you're doing is cool. Yeah, there's some wisdom there for sure.

I mean, I tell people all the time, I'm like, you are so attractive for 70. And they're like, thanks. I'm like, I don't mean that. And any, just good job. Like high five. So strength like, I don't mean that in any, just good job. Like high five. So strength train, cardio is overrated. I was like, okay, that took me about 10 years,

probably more to even believe him. Um, he told me to keep your waist circumference as low as possible. Always. That's a big thing. Never let it creep up no matter what. He said, if you gain weight, like postpartum, for instance, after I had my baby, he said, get it off as soon as possible

before your weight resets, before you get, your body hits that set weight and recalibrates. There was no paleo diet or carnivore diet back then, but he always told me that stay away from breads, like white carbs, just avoid white carbs if you want to age well. They'll put you to sleep, they'll give you insulin resistance. He told me that every woman over 40 needs a little bit of thyroid replacement, which I

totally abide by. And he taught me how to treat pain, which is very rarely due to a mechanical issue, you know? So pain is so hard to treat, by the way, I trained a pain specialist and I remember he broke down like, he's like, there's physiological stuff that's happening for pain. And this is a perception of pain and the

interplay between the two. Yeah. And it's like, you know, and then I. It's in the brain. Yeah. And I'd read studies on people who get rid of depression, their back pain was gone or, I mean, or people with MRIs, everything looks perfect.

They have this chronic pain or people with MRIs, everything looks bad and they have no pain. It's a huge mystery. Yeah, so he was always pounding in metabolic health and how you needed muscle. So that is why I'm, when people wanna give me shit, I'm like, dude, this isn't just me, this is my legacy. Like I have been, this is decades of me preaching this.

I just happened to grow a little Instagram. But this is the flag I carry, and he was right about all of it. It's crazy he was touting that in 95. We're coming up on our 10 year anniversary and one of the things that we used to get so much heat for is we used to, like one of the big viral videos was, you know, cardio is terrible for fat loss. We used to say stuff like that and people were just, would freak out. And we'd be arguing with doctors. It was crazy that and people were just would freak out. And are we be arguing with doctors? It was crazy how many people were so, so the fact that he was teaching that at 95

is, is incredible, man. That's awesome. Yeah, that's awesome. So a lot about you and where you're at for sure. Uh, a hundred percent. Yeah. That's hope we can influence the, uh, because I really want to be on the right side with this cause I could see potential for abuse or just potential

for not using it properly. But you know, when I talk to people like you and I talk to people like Dr. Seed's who I love, I hear like, if you do this right, like this could be a game changer. That's what it feels like. It's a total game changer. I just, it's just one tool in a toolbox though,

right? Like this is a comprehensive toolbox and that's what I'm always trying to teach is all the things. I call it all the things. You got to do all the things and it's just not one tool. We don't do monotherapy at high dose of anything. And that's what's inherently being done improperly.

I think with this is they're using it as a monotherapy and they're doing it high dose. And my mentor would have been all over this. Actually, I still talk to him. I like still communicate with him. And I remember when I got really excited about this, I was like, his name was Rick Maranelli. I was like, Rick would have been so fucking stoked about this because of the impact on pain. I didn't talk about that.

It's not just the psoriatic arthritis, autoimmune component. Like my pain goes down significantly when I'm on it. And the impact on pain, I had so many patients, I could do all the injections in the world and do all the hormones and do all the gut therapy, all the things. I couldn't get their pain down and it's just, it's soul crushing work really. It's one of the reasons I closed my practice. You just can't, being in the business of pain has a shelf life and I hit mine. And if I had had these as a tool when I had my big practice, when I was like, you know, I was a very busy doctor.

I would have probably had everybody on some, as a trial at the very least, just to see if we could impact pain. Do you have any other favorite peptides you'd like to combine with the GLP ones? I love BPC 157. I think it's very, very nice. I liked it better when I could inject it.

I like injecting anything though, cause that's what I did. I injected. Oh yeah. That's what I did. I did injections. I dropped four inch needles into people's spines, you know, so for a living. I loved it when I could inject it, although the impact of it orally, it's available oral still over the counter and it's amazing to heal the gut. And when you heal the gut, you heal so many other things. So wonderful, wonderful peptide. I like all of the growth hormone releasing hormones that, I mean, I think we still have

Tessamorlin, we still have Samorlin, right? Those are great, done right. And I saw you actually today on Instagram, on Areal, talking about how you can't build and lose at the same time. And that's something I really try to drive home to people is like, so I've been on the peptides trying to get my dose right on the, um,

semaclutide and terzepotide to get my dose right so that I could figure out what the dose was for my immune system. But in that I've lost weight. And so I've given myself that time and now I'm back to a build cycle. Like I got my dose as low as I need, very, very low, and then I can go back to building and

putting some muscle mass. I haven't lost any strength though, you know. That's great. So anyway, back to the peptides. I like KPV. I think that's a very cool one for inflammation. We don't really have a ton left, you know? Yeah.

I think we have VIP still available. We, that's, they kind of took everything away in one fell swoop. Yeah. Well, our, our, we have partners that we work with and they have access to almost everything, still, which is, which is pretty good. But a BPC was, and Thymus and Beta, those two for me, I absolutely, I mean, they're

just remarkable for me. I can only talk about the ones that are still available legally as a physician, well, I know legal, but I can only talk as a physician who prescribes, I can only talk about the ones I can still prescribe, but there's still some cool oral ones you can get. And they work great. I can only talk about the ones I can still prescribe, but there's still some cool oral ones you can get. And they work great. So what do you think moving forward, they're gonna try and get rid of the compounded versions

of these so they could maintain their prescription name brands? I don't know. They're really on a bender about it though. It seems like every other week there's some big, and you get through the whole article. I read the whole article and they're talking about, you know, there's fake smaclutide out there and

that's causing problems and all these people are in the ER. Cause at the end of the day, you do have to pull up the syringe full of the peptide and the peptide compounded can come very concentrated and just the tiniest little bit too much. I don't know if you experienced this, but I go just a tiny bit too much just because I didn't

eyeball it correctly. Cause I didn't have enough light coming through the syringe and like that next week can be very uncomfortable for my stomach. So I think folks are getting themselves into trouble by and they want the fast route. Like the woman who got. Think a little bit more is gonna be better.

It's not better. This is a slow and low process, very low. And we want what? Like I don't know what you guys like to get people to lose, but a pound a week is the most I want someone to lose. No, if I have somebody, we actually communicate many times that maintaining the scale, because if we do a really good job of kind of like cycling our calories, you should be building a little bit of muscle, losing a little bit of body fat, building a little bit of muscle. And sometimes I'd rather see the scale stay the same than see four

or five pounds come off. Initially, for sure. Yeah. Can we talk about that too, because I made a comment on Dr. Mark Hyman's podcast about how, you know, losing the weight's actually the easier part, maintaining the weight loss is the challenging part. Always.

Right. And people don't understand that. A lot of people got mad at me and, and had some words to say to me and they're like, oh, you think it's so easy. I'm like, no, really that's actually the easier part, the maintenance, because the le left end changes, your brain changes. There's like permanent changes in the brain, in the, in the, in the

plasticity that happened, you get rewired. Every time you go through a weight loss phase, you just, your body now. It will be more difficult to maintain that weight loss with each and every round. It's also just from a behavioral standpoint, uh, when, when I mean, just when you're chasing a goal and you're set on that goal and that goal, you're married to that goal. And man, when I lose 30 pounds, everything's

going to change. And then you lose 30 pounds and everything doesn't change. Some things change, but everything doesn't change. Then it could be very difficult to stay on that path. Or if you do everything and you throw everything but the kitchen sink at yourself, then you end up

setting up a precedent that you can't necessarily maintain because it takes time to build the skills and the discipline in order to do it. So there's a lot of reasons why, but you're right. But no, to back you up, I mean, I used to tell clients that they'd come in and they would just be so adamant about losing 20 pounds. I just want to lose 20 pounds.

I said, well, that's really easy. Don't eat for the next two months and I'm going to have you walk on the treadmill. And then I would laugh and say, of course I wouldn't do that to you. But the problem with that is that, and that's what people do is they do these extreme diets and you get metabolically adapted to that new chloric intake. Good luck only eating 500 calories for the

rest of your life. So yeah, maybe you made it down to your goal weight, but to your point why it's so hard to maintain that is now you have so little room and flexibility for life. You can't have a glass of wine at dinner anymore. You can't enjoy dessert every once in a while after because you've now become metabolically adapted to eating 800 calories a day and anything above that. And what people have to understand is that when you get that low, the ratio of a glass of wine is tremendous versus the person

who decided to do it slowly, build their metabolism, build muscle, and actually metabolically adapt in the other direction where you actually have a fast metabolism. Then when you have a glass of wine, a glass of wine compared to someone who can eat 2800 calories a day is nothing, but somebody can only eat 800 calories a day. It's half their intake. That's a big deal. So. That's why you have to build muscle when you're on these.

Have to. Because your leptin is in your fat and as you lose fat, you lose leptin. And as you lose leptin, your body, your brain doesn't know how much energy you have in the system. And so you come out leptin deficient. So now you're hungrier and they're still leptin resistant if they didn't do all the, so leptin

resistance, think of it as going hand in hand with insulin resistance. The way to correct it really is many of the same things that we do to correct insulin resistance. So now they're, now they have less leptin, which they need more of, they need more leptin if they want to stay thin or lean.

And now they're still leptin resistant because they didn't do any of the other things during the process of that window of opportunity that they just got. And they didn't build any muscle. They probably lost muscle. It's a disaster. So this is even more incentive to the listeners to get a strength training program going and make sure you're doing all the things right.

So you're not left in this just pit of despair at the end. No, love it. Love what you're doing. Absolutely love what you're doing, Dr end. Yeah, yeah, yeah. No, love it. Love what you're doing. Absolutely love what you're doing, Dr. Nia. You're like one of the good guys for me. Are you speaking in Vegas? I found out we're all gonna be in Vegas at the same time. We're gonna be in Vegas.

No, I'm just going. You're just attending. Oh, awesome. Honestly, I've been so isolated the past couple years. Like nobody wanted to touch me in the last couple years. They agreed with me and they knew I was right, but they were like, she's controversial. We can't have her on our show.

We love controversial people. Thank you. Thank you. I, no, I just, I was like, I need friends and I really like that group. That's probably one of the, it is the only group that I know in the anti-aging space or the longevity space or the functional medicine space where like, they all lift. They all get it, you know? And you go to these conferences, these anti-aging conferences. I was sitting one in December in Vegas and it was like, you know, A4M, the big anti-aging organization, and it was this GLP-1 one day conference and like the whole room, like the

guy next to me is crushing a frappuccino and then passes out on his computer like an hour later and the other guy's eating danishes and sitting there, you know, just having that like metabolic sweat afterwards. And I was like, what the hell is going on? And the rest of them were people that ran Medi spas who there was like two people in there that looked like they lifted weights and I was like, these doctors don't get it. So I feel like the doctor seeds group don't look like they get it.

Yeah. Dr. Seeds come on the show. He sat down. I'm like, uh, you're Jack. That whole group's awesome. Oh, you gotta make sure you come over then too, and then come say hi to all of us. So we'll have a, we have our live event going on at the same time. So I'll be speaking at the event. He wants me to speak about, you know, strength training, resistance training. So it'll be, it'll be a lot of fun. Yeah. Awesome.

Well, thank you so much. And I hope our listeners come check out your podcast and all that you do so they can get some. We'll do it again for sure. 100%. Yeah. Thank you so much. And if they ever kick you off again, your friends with us. We got you back. Over the rebellion.

Yeah, yeah. We got you back. Thanks guys. Thank you for listening to Mind Pump. If your goal is to build and shape your body, dramatically improve your health and energy and maximize your overall performance, check out our discounted RGB Super Bundle

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