The Ultimate Human with Gary Brecka - 141. Max Lugavere: Seed Oils, LDL Cholesterol & Inflammation

Episode Date: February 18, 2025

What if everything you thought you knew about “heart-healthy” cooking oils was based on outdated science and clever marketing? In this episode, I’ve sat down once again with Max Lugavere, and we...’ve had an amazing conversation about the metabolic chaos that modern seed oils are silently creating in our bodies, and why the food industry’s favourite oils might be driving the global rise in chronic disease. We also uncovered some actionable steps that we hope to see prioritised with the new government, and especially with the Make America Healthy Again movement. Ready to transform your understanding of nutrition and take control of your overall health? Hit subscribe and share this video with someone who needs to hear this message. Join Gary Brecka’s FREE 3-Day Morning Routine Challenge! 🗓️ LIVE February 19-21  👉 Sign up now Gain exclusive access to Gary Brecka’s proven wellness protocols: https://bit.ly/4ai0Xwg Connect with Max Lugavere: Get Max Lugavere book, “Genius Foods”   Listen to "The Genius Life" on all your favorite platforms! YouTube: https://bit.ly/3X5fVQO  Spotify: https://spoti.fi/4gJiBL8  Apple Podcasts: https://apple.co/4gOCmAS    Connect with Max Lugavere: Website: https://bit.ly/3XLOGdN  YouTube: https://bit.ly/4eJc6r7  Instagram: https://bit.ly/3BsEf7y  TikTok: https://bit.ly/3Y8ov2w  Facebook: https://bit.ly/3Y4QkZr  X.com: https://bit.ly/3ZMQgPk   Thank you to our partners: BODYHEALTH - USE CODE “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV BAJA GOLD - USE CODE "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa EIGHT SLEEP - SAVE $350 ON THE POD 4 ULTRA WITH CODE “GARY”: https://bit.ly/3WkLd6E STRENGTH TRAINING EQUIPMENT - THE ULTIMATE HUMAN: https://bit.ly/3zYwtSl COLD LIFE - THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp WHOOP - GET 1 FREE MONTH WHEN YOU JOIN!: https://bit.ly/3VQ0nzW MASA CHIPS - GET 20% OFF YOUR FIRST $50+ ORDER: https://bit.ly/40LVY4y VANDY - USE CODE “ULTIMATE20” FOR 20% OFF: https://bit.ly/49Qr7WE PARKER PASTURES - PREMIUM GRASS-FED MEATS: https://bit.ly/4hHcbhc AION - USE CODE “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD HAPBEE - FEEL BETTER & PERFORM AT YOUR BEST: https://bit.ly/4a6glfo CARAWAY - USE CODE “ULTIMATE10” FOR 10% OFF: https://bit.ly/3Q1VmkC Watch the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka: Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X.com: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps: 00:00 Intro 04:11 What is Seed Oil? And Why Is It Bad For You? 10:21 Polyunsaturated Fatty Acids in Seed Oils 14:25 Awareness on Food Labeling 20:28 High Volumes of Oxidised Oils in Blood Stream Risks 25:55 Animal-Source Foods Play an Important Role in an Optimised Diet 36:00 Randomised Clinical Trials on Red Meat 38:48 Top 5 Sports Supplements 42:25 Supplementation for Vegans and Vegetarians 45:02 Actionable Steps the Government Can and Should Do  54:54 Nutrition for Brain Health 59:22 Final Question: What does it mean to you to be an “Ultimate Human?’ The Ultimate Human with Gary Brecka Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The Content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript
Discussion (0)
Starting point is 00:00:00 Least healthy foods in the supermarket make the loudest claims. It should be banned that ultra processed foods are allowed to make health plan. There's such a large percentage of our public policy nutritional research is funded by pharma. I think this has got to be partially responsible for an upside down food pyramid. You know, Lucky Charms, My Nutrition System, Grass-Fed Steak. I'm happy with products marketing how they've been produced. If it wants to say organic, great. But it's the health claim.
Starting point is 00:00:24 Just be a level playing field to inspire consumers to learn for themselves. We're both connected to this Make America Healthy Again movement. I'm optimistic that we can raise more awareness around this topic and call for better science. We've privatized profits and we've socialized the expense. Medicare is picking up the cost of this burgeoning, explosive era of chronic disease and morbid obesity. Obesity has tripled over the past 50 years. Our genes have not changed all that much. Our lifestyle, our food environment has dramatically changed. In a perfect world, what are some real actionable things that the government could do to
Starting point is 00:00:56 make the biggest impact in the shortest amount of time? The motivation is there to uncouple some of the many conflicts of interest. I remain totally optimistic, but what can they do? You know, I think for one. Hey guys, welcome back to the ultimate human podcast. I'm your host, human biologist Gary Brekka, where we go down the road of everything anti aging biohacking, longevity, and
Starting point is 00:01:28 everything in between. And a trip to LA would not be complete without having Max Lugavere back on the podcast. It was one of the best podcasts that we've launched. I mean, the the story that you told about your journey with your mother and Alzheimer's, and how you really became an advocate. And I say this all the time. I feel like I start every podcast the same way, but I've truly found that people
Starting point is 00:01:53 that are the most impactful, the most passionate, the most driven and purposeful are people that solve the problem in their life. And you really solve the problem when, you know, your mother was probably the closest, I'm gonna assume relative to you, you know, went through that time and you just said I, I need answers. And so if you guys have not watched the podcast that I do with Max on
Starting point is 00:02:15 the journey with his mother and how he became an advocate for mental health, it's a really it's a phenomenal podcast, I linked all of the research in the in the show notes and even gave a link to the documentary that he did a phenomenal podcast. I linked all of the research in the show notes and even gave a link to the documentary that he did with his mother. I was, you know, before every podcast, and I know you so well, and we just had a great time at the Maha ball,
Starting point is 00:02:34 which was awesome. We had a great time at the turning point ball, which was a great time, other than the weather. It was like a freaking nine degrees. And all the women were walking a mile in open toed heels. I know it was like being in a cryotherapy chamber like Yeah, I didn't think about it that way. I should have turned that into a positive and then like, I'm
Starting point is 00:02:53 getting all this vasoconstriction and brown fat activation and dopamine but but I was actually pissed off so maybe the dopamine didn't work. I know we're constricted you're wearing a tux it's like But I ran into a great clip that you did. And I think it was either during a congressional hearing or when you're on Capitol Hill not too long ago, and you made a comment and you said, if your grocery store has a health food section, what does that tell you about the rest of the grocery store? And you know,
Starting point is 00:03:21 as obvious as that is, it just made me go, you know, it's it is so true. And it's so interesting how, you know, we're both connected to this Make America Healthy Again movement. And we're both committing time and resources and our platforms to it. And it's astounding to me how bad it's really gotten. And, you know, just how far away from the basics, you know, eating whole foods and nutritious soil and and getting back to the basics, the war on saturated fat basics, you know, eating whole foods and nutritious soil and getting back to the basics, the war on saturated fat,
Starting point is 00:03:48 the promotion of seed oil, the allowance through grass that's generally regarded as safe guideline that the FDA has that we can actually take micro toxins on a regular basis. And so I wanna kind of roam around that with you because I consider you an authority on that. And, and maybe we should start with one of the most controversial topics, which is seed oils. And I think that a basic explanation of what
Starting point is 00:04:16 is a seed oil? Why is it bad for you? And so pro inflammatory, we had an awesome discussion before the podcast started about, you know, its impact on LDL cholesterol. And I thought that your viewpoint on that was really good because you talked about the house of cards collapsing on LDL cholesterol. So I wonder if you might expand on that. Yeah. So seed oils are a obviously very controversial today.
Starting point is 00:04:39 Everybody's talking about them. I actually, I think was very prescient in my, you know, diving into this topic in my book Genius Foods, which came out in 2018, which I the manuscript I wrote around 2016. And there have been other people sort of broaching this issue. I mean, Weston a price I think was one of the earliest people. Paul Sandino has been big on it. Talk about it. Yeah, Kate, Dr. Kate Shanahanahan You know, the evidence is kind of all over the place and I think it's a little bit we have to talk about seed oils not as a monolith but with with nuance and You know when discussing these kinds of oils there are the culinary oils like sesame seed oil
Starting point is 00:05:19 Which have been used in various traditional cuisines for millennia been used in various traditional cuisines for millennia, which I think can be perfectly healthy and add great qualities to certain recipes. I think those are fine, but the oils that are in question, particularly today, are the what are sometimes referred to as RBD oils, which stands for Refined, Bleached, and Deodorized oils. These are the highly marketed cooking oils that have only really had a presence in the human food supply for the past couple of decades. And the issue with these and even within the refined, bleached and deodorized seed oil category,
Starting point is 00:06:00 first of all, when you say for refined, bleached and deodorized, I mean, that you should come to a full stop right there, because there's no mechanism in nature for something to be refined, bleached, or deodorized. Correct, yes. So I mean, we've now, I think, many of us in the nutrition community are placing an emphasis on awareness around ultra-processed foods, right?
Starting point is 00:06:19 We generally want to minimize our consumption of ultra-processed foods, which now make up 60% of the calories of your average adult. But what about ultra-processed food ingredients? And these refined bleach and deodorized seed oils are ultra-processed. By definition, a food that is ultra-processed is something that you couldn't possibly make in your own
Starting point is 00:06:38 kitchen if you tried. You could make sesame seed oil in your kitchen, right? To make sesame seed oil, you press sesame seeds. You could conceivably make extra virgin olive oil in your kitchen, right? To make sesame seed oil, you press sesame seeds. You could conceivably make extra virgin olive oil in your own kitchen. Humans have been making and consuming extra virgin olive oil for centuries at this point. I'm a huge fan. Me as well. I actually start the morning with a shot of it.
Starting point is 00:06:58 But you couldn't realistically create one of these RBD oils like soybean oil or corn oil in your kitchen. They often require industrial machinery, chemical solvents like hexane. So right off the bat these oils are ultra processed. We know that. The ultra processing designation comes from the Nova paradigm out of Latin America and so it's a little bit unclear. I think the technical definition might not necessarily place corn oil and soybean oil under that in that category. But they are, there's no question you couldn't make them in your own kitchen. I mean, you would need some serious chemistry to do so.
Starting point is 00:07:37 Right. Plus most of us don't have hexene and sodium hydroxide just lying around. Exactly. There's actually a, there was a viral video on Instagram by a really wonderful content creator and I forget his name, but I'll send it over to you and you can perhaps include it in the show notes. It was actually a guy who seems to, who appears to have a chemistry background, attempts to make a refined bleach and deodorized seed oil in his home kitchen. And it's pretty terrifying.
Starting point is 00:08:03 Really? Actually. Yeah, yeah. All the myriad production steps. But nobody's doing that at home for the most part. I'm going to try to dig that one up. Yeah, yeah. Callie just did it. Callie Means is another good friend of mine.
Starting point is 00:08:16 And someone I deeply, deeply respect just did a post on the sequence in the manufacturing of seed oils. I thought it was really good. Yeah, they're often exposed to high heat. But it should be said that processing doesn't necessarily make a food unhealthy, right? Even within the bucket of ultra-processed foods,
Starting point is 00:08:36 ultra-processed foods are not a monolith. Some are better for you than others. So what is it specifically about refined bleach and deodorized seed oils that make them, that should ought to inspire caution when over consuming them. Well, for one, they are novel fats. So again, these didn't exist in the human food supply prior to 50 to 70 years ago. So right off the bat, I think we should embrace by default
Starting point is 00:09:05 what's called the precautionary principle. So the less time a food or an ingredient or product is, humans have been exposed to it, the more skepticism, the more caution, the higher the burden of proof should be on that food to prove itself as safe. As opposed to the burden of proof being on the consumer or the researcher to prove it guilty, right?
Starting point is 00:09:26 It should be guilty until proven innocent. And that's what's referred to as a precautionary principle. It's something that actually in the EU, that seems to be the norm for food additives and the like. Here, the burden of proof is usually on the consumer to prove something, to prove that something is unhealthy. And usually that occurs years, if not decades, after many, many people have been exposed to it.
Starting point is 00:09:48 And we've seen that with red dye three, which was just banned. Yeah, that was a good move. After decades. And just to start, we need to go through the other 40 and some of the other ones. There you go. So I think the precautionary principle is super smart. It's something that we don't generally
Starting point is 00:10:00 abide by here in the United States. And I think that's unfortunate. So these ultra processed oils are novel, right? Now again, that doesn't necessarily make them bad, right? So we have to peel back the layers of the onion even further, right? The problem with, I think one of the major problems with these oils is that they're predominantly comprised
Starting point is 00:10:19 of polyunsaturated fatty acids, which are the most chemically unstable. So among the fatty acids that predominate our diets, you've got unsaturated fatty acids, which are the most chemically unstable. So among the fatty acids that predominate our diets, you've got unsaturated fatty acids and you've got saturated fatty acids, right? Those are the two major categories. Saturated fats are the most chemically stable. They tend to be solid at room temperature.
Starting point is 00:10:38 And under the bucket of unsaturated fats, you've got your polyunsaturated fatty acids and your monounsaturated fatty acids. Polyunsaturated fatty acids and your monounsaturated fatty acids. Polyunsaturated fatty acids are very prone to a chemical process known as oxidation, where essentially the oils go bad. They go rancid. And that process is catalyzed by exposure to light, heat, and oxygen.
Starting point is 00:11:00 And so these refined bleach and deodorize seed oils are, they tend to be predominantly polyunsaturated in nature. And that's not the case for all of them because there are seed oils like high oleic sunflower oil, which I actually think is fine because it's mostly monounsaturated fat, which has a degree of chemical protection. It's less prone to this oxidative process, but polyunsaturated fat, which has a degree of chemical protection. It's less prone to this oxidative process. But polyunsaturated fats are essentially
Starting point is 00:11:28 naked because they're the most prone to oxidation. And they're extracted from the food matrix, which often coincides with antioxidants that protect those fats. In fact, in nature, where you see higher levels of polyunsaturated fats, you also see higher levels of certainunsaturated fats, you also see higher levels of certain antioxidants like vitamin E, whose role in nature is mainly to guard these polyunsaturated fatty acids against oxidation. So in foods where you have higher levels of polyunsaturated fats, you see higher levels
Starting point is 00:11:58 of vitamin E, which is why nuts are one of the primary sources of both polyunsaturated fats in the, in the diet as well as vitamin E. Okay. I didn't know that. Polyunsaturated fats are not inherently unhealthy. And vitamin E is super important from a brain health standpoint. The problem is when we extract these fats from the whole food matrix and we expose them to these, you know, caustic chemical solvents like hexane or others. And then we expose them to these caustic chemical solvents like hexane or others. And then we expose them to heat, which often occurs during the deodorization process. And then we further use them to cook them, to cook with, which ironically is what they're
Starting point is 00:12:37 marketed as being ideal for. Then you're further catalyzing this oxidative process to these polyunsaturated fats, which are very vulnerable. And, you know, oxidation occurs when we ingest these fats in us, you know, but it can also occur in the external environment when they're used in the fryer setting, when they're used to, you know, create ultra-processed foods. And so that's potentially really harmful.
Starting point is 00:13:03 The other problem is that there are byproducts of oxidation. So it's not just that the fatty acids themselves become oxidized, but all of these other nasty compounds are generated. When a high polyunsaturated fatty acid dominant seed oil is exposed to high heat and reheated in particular, you're not just damaging the fatty acids, but you're generating all of these noxious compounds like acrolein and four-hydroxynoninol,
Starting point is 00:13:32 which have been shown to be cancer causing and be associated with conditions like Alzheimer's disease, four-hydroxyn nonanol in particular. And this doesn't exist in the seed oil. Initially, this exists when the seed oil becomes oxidized. And I think the oxidation process, which is also a pro-inflammatory process in the human body, when you have oxidative free radicals in the human body, you create inflammation. And you see, again, it's not causal, but it's correlated. You see significant increase, dramatic increase in the consumption of things like refined sugar, but also the consumption of C2Ls.
Starting point is 00:14:17 I mean, you really can't get away from them. I mean, even if you go to, you know, and my favorite thing is that most of them have a heart healthy label on American Heart Association says beautiful picture of a heart with a smiley face and and there and and the bright eyes that's on the on the bottle of seed oils, but the Amount of their consumption too is well people go well I don't grab Weston oil off the off the shelf
Starting point is 00:14:43 But you know you start spinning around the labels of your, you know, your salad dressings and and most, you know, a lot of your seasonings and, and even some extra virgin olive oils, you know, and until Paul Saladino brought this to my attention was a few years ago, I actually thought extra virgin olive oil was extra virgin olive oil. And then when you spin the label around, it's like extra virgin olive oil is extra virgin olive oil. And then when you spin the label around, it's like extra virgin olive oil, palm oil, cottonseed oil, canola oil, and it's right in the
Starting point is 00:15:11 bottle that and all it says on the label is extra virgin olive oil. And it's and you know, part of I think, the issue and what, you know, hopefully we're going to help solve with this maha movement is that, you know, the average consumer doesn't stand a chance. I mean, I can consider us to be pretty woke and educated in this arena. And, you know, just getting to the grocery store and just getting through that as it's a task. Right. And so you think about the middle American mother
Starting point is 00:15:39 and fathers trying to do the right thing by the family and trying to raise their kids and trying to eat healthy. And, you know, as I'm cruising down the aisle, I see things like fortified, enriched, heart healthy. Okay. Those are the things that I'm going to grab and throw in my, you know, in my basket. Right. It's a bit, it's a, it's a huge problem. And yeah, you know, I'm, I'm optimistic that we can raise more awareness around this topic and call
Starting point is 00:16:04 for better science. Because again, the science is a little bit all over the place and this is a controversial topic. I mean, it's actually very, this is a very unorthodox perspective that we should be avoiding seed oils. I mean, I'll say with all transparency that like if you were to ask your average dietician,
Starting point is 00:16:21 for example, what they think about seed oils, they'll say that they're not only benign, they're not harmful, but they're actually good for you. And so I think, you know, this is something that we're gonna need a lot more research to say with certainty, but based on this line of thinking that I've, you know, at least begun to lay out,
Starting point is 00:16:40 I think that we should all have a little bit more skepticism around them. And, you know, like linoleic acid, which is the form of polyunsaturated fat that dominates these seed oils is also found in extremely healthy foods, like again, nuts and seeds and things like that. And you find linoleic acid in animal-sourced foods, egg yolks and things like that. And so a lot of the observational data on this, like when they'll correlate blood levels of linoleic acid, for example, to certain health outcomes, it actually seems positive
Starting point is 00:17:11 from that perspective. But there are a lot of confounding aspects to that observation. For one, nuts and seeds and other foods, as I've mentioned, that are high in this fat are healthful. And then also there is what's called healthy user bias,, you know, these oils are adorned with the heart healthy logo on them. So a health conscious person might be more inclined to consume oil and corn oil and soybean oil. Now is their health good because of these oils or perhaps in spite
Starting point is 00:17:38 of these oils? I mean, that's a health conscious consumer, right? Maybe they're more inclined to take a multivitamin or maybe they're less likely to smoke or drink alcohol excessively. So when it comes to snacking, masa is flipping the script on what real food should look like. masa chips are crafted with grass fed beef tallow, one of the healthiest fats on the planet. These chips are packed with essential vitamins like vitamin A, D, E and vitamin K two, all of which
Starting point is 00:18:03 play a role in keeping your skin vibrant, your immune system strong and your bone solid. But here's the real magic about masa. masa's corn goes through an ancient process called nick stabilization, which makes it way easier to digest and it amps up its nutrient profile. Plus these chips are low in PUFAs. So you won't find any of the inflammatory seed oils that you find in most snacks. And instead masa uses pure Redmond sea salt giving you a natural hit of minerals that keep your cells hydrated and your energy steady
Starting point is 00:18:34 So don't just snack reach for masa It's real food real health without any of the junk grab a bag and I promise you'll feel the difference Now let's get back to the ultimate human podcast Well, you know anything you see such a parabolic rise in nearly all forms of chronic disease, autism, ADD, ADHD, OCD, panic, depression, bipolar, schizophrenia, and then also the more physical characteristics, obesity, multiple chronic disease in a single biome, all of which the United States is leading the world in. As we drop to 66th and like 66th in life expectancy, you know, we are leading in these areas that we don't want to lead, especially after spending four and a half trillion dollars a year on health care. You think
Starting point is 00:19:15 if we spend four and a half trillion dollars, man, we should all be flying around with a cape. For four and a half trillion dollars, we should be the healthiest, you know, nation in the world. But and, and, you know, I'm only cautious to say the pandemic of obesity or multiple or chronic disease is directly related to seed oil consumption. I think it is multifactorial. This is certainly a factor. You know, I don't think that the jury is out on, you know, oils becoming't think that the jury is out on, you know, oils becoming rancid at high temperatures. And
Starting point is 00:19:49 therefore, you know, at least, you know, to be prudent, if you were to wipe seed oils out and add things back in, let's say room temperature oils, like extra virgin olive oil or cooking in high smoke point oils, like, you know, coconut oil or grass fed butter, ghee butter, you know, coconut oil or grass fed butter, ghee butter, tallow, some of these oils that actually can withstand those temperatures. Quite frankly, I think things taste better. Personally, when you cook in
Starting point is 00:20:16 those oils, and they're the only things you really need to have around your kitchen. But process process of oxidation in seed oils, what are some of the outcomes of having these oxidized oils in high volumes in the bloodstream? Well, one effect which they've so people can look up. There are two, there, there's a lot, there are many different researchers, you know, working on this, but there have been some really interesting papers, clinical trials by a researcher with the last name of Ramsden and then Taha. And there was one paper in
Starting point is 00:20:58 particular that I often cite, it's actually a review, so it's pretty easy to read by Taha, single author paper published in 2020, looking at linoleic acid and its impact on the brain, which is obviously a topic that I'm incredibly passionate about because my mom had dementia from a young age and I'll never know what caused her dementia. I don't know if it had anything to do with, you know, her exposure to these, her lifelong exposure to these kinds of fats. But yeah, it doesn't seem that consuming excessive amounts of linoleic acid, which again, predominates these oils in question, linoleic acid has easy access to the brain. And it's a fat that's incredibly prone to oxidation because of its, you know, its polyunsaturated
Starting point is 00:21:41 nature. And the human diet is now, I mean, saturated with this with this type of fat. I was reading a study that came out in 2023. And it painted the picture very plainly that you know, in 1910, more than 90% of the fats in the human diet were of animal origin, 90%. Wow. Yeah. And now that figure is like, it's less than 15%. I mean, it's way lower. And the bulk of those fats have been replaced by these grain and seed oils.
Starting point is 00:22:16 Like most of the majority of fats in the human diet today come from soybean oil and corn oil. Yeah, and canola. Yeah. Yeah. It's like, and canola. Yeah. Yeah. It's like, it's shocking. So the fact that these, you know, the idea that these fats are benign
Starting point is 00:22:31 and not having some kind of physiologic effect, I mean, it's just that that doesn't even pass like logical muster, you know? It's like, of course they're doing something. We just have to figure out what that something is. One thing that they do do, and this was actually shown in a paper by Ramsden, I forget which year, but people can look this up, is that they increase in the blood something called oxalams, oxidized linoleic acid metabolites. And these have been
Starting point is 00:22:55 associated with Alzheimer's disease. I mean, these compounds. Aflerosclerosis. Yeah. Yeah. Narrowing of the arteries. You find a lot of these oxidative species, you know, at the site of inflammation and also, you know, at the site of, you know, where cholesterol coalesce into, you know, these plaques. And I think, often we, we blame cholesterol for crimes, it's not committing. You know, I often refer to cholesterol as a fireman, you know, your house
Starting point is 00:23:24 catches fire, the fireman shows up to put the fire out. But it didn't just show up randomly, right? I mean, if this Airbnb never caught fire, firemen would never show up in the driveway, right? But if it did, they would show up to extinguish the fire cholesterol is usually called to the site of inflammation. And I think it's something that goes lost on a lot of folks, They just think because of the presence of LDL cholesterol, especially, especially if LDL cholesterol is in higher amounts, then I have a higher risk for narrowing of the
Starting point is 00:23:55 arteries or arteriosclerosis. But that's, that's like making the argument that if there were more firemen, we would have more fires. But you know, that line of thinking is not not true. And I think it is about to be majorly disproven. But one of the things that I liked that you were saying before the podcast started was, we have to understand that, you know, these these polyunsaturated fatty acids are built on the backs of this entire house of cards built
Starting point is 00:24:24 around LDL cholesterol. And if one of those cards like polyunsaturated fatty acids falls apart, the house of cards starts to come down because you're like, well, if the fact that these, because the, the, the, the pro seed oil discussion is, well, they lower LDL cholesterol and is an LDL cholesterol, and is an LDL cholesterol terrible? Is an LDL cholesterol bad for you? Is an
Starting point is 00:24:48 LDL cholesterol the genesis of all heart disease? I mean, shouldn't you if you have high LDL cholesterol, lower it as low as you possibly can. And if seed oils lower LDL cholesterol, then the arguments over there. They're not bad for you. Yeah, I mean, I've said that LDL cholesterol isn't just a biomarker, it's an industry. And it's not just one industry.
Starting point is 00:25:13 Yeah, I love your one liners, man. It's like, I like the health food line. I'm gonna borrow that. You can see it start creeping up in podcasts. Yeah, yeah, yeah, feel free, use it, use it, credit me. But, or don't, I don't know. Be cruisin'. So it's an industry, this LDL cholesterol is an industry. Yeah, and so this notion that seed oils are good for you,
Starting point is 00:25:39 refined bleach and deodorized seed oils are good for you. It's true that seed oils reduce LDL cholesterol relative to certain saturated fatty acids. And so you have to accept that as being a benefit because if that's not a benefit, then suddenly animal source foods are not the dietary villain that they're often made out to be. And suddenly statins, their LDL lowering effect might not necessarily be of benefit. Stat has have pleiotropic effects. They're also anti-inflammatory, but exactly. Yeah. Yeah. Very interesting podcast, uh, with Dr. Gundry on that, um, in talking about the,
Starting point is 00:26:16 the research on, uh, the minimal impact that, uh, you know, that statins had on life extension, which was very, very minimal and the impact that it had on cardiovascular disease coming from the anti-inflammatory effect, not actually from the LDL lowering effect. Yeah. So I mean, it's the house of cards that you referenced is something that I think it's really important. Like that seed oils are heart healthy is a card in that house of cards.
Starting point is 00:26:46 And for us to challenge that assumption, well then that might lead to a reassessment of all of these other assumptions that we make about what causes heart disease, maybe saturated fat isn't the dietary villain that it's, you know, often for decades made out to have been so so yeah, that's why I think it's It's been a real challenge to to actually address this stuff because there's so much commerce Yeah, I to it and I'm not saying that LDL cholesterol is unimportant that able be is unimportant. But the
Starting point is 00:27:22 But you know heart disease is multifactorial important. But the but you know, heart disease is multifactorial. Right. Yeah, I don't think it's directly causal for LDL cholesterol or directly causal for seed oils. Yeah, either. But I think the more of these things, you know, it's interesting as I sort of travel the world and talk to experts like yourself and other experts and PhDs and MDs and researchers and are leading minds in the field. Yeah, so we're we seem to be coming full circle,
Starting point is 00:27:45 you know, and just getting back to the basics, you know, a lot about what you talked about, how a lot of these polyunsaturated fatty acids weren't even in the diet in the 1900s. And you also saw significantly lower rates of cardiovascular disease. Cardiovascular disease is a relatively new phenomenon, especially in younger ages.
Starting point is 00:28:04 Not, you know, in older ages it was certainly a phenomenon but it's becoming younger and younger and so is metabolic syndrome. I read a really interesting article and had a discussion with Dr. Gondry about this, about you know the metabolic syndrome which we were discussing before the podcast, you know, abdominal adiposity, hyperinsulinemia, hypertriglyceridemia, you know, elevated or suppressed HDL cholesterol and high blood pressure. We really tend to think of these things as these are older age problems, right? Like we think Alzheimer's, dementia, cognitive decline. I'll start worrying about that in my late 60s, my early 70s. But all of
Starting point is 00:28:48 these things have a genesis that's decades earlier than then they manifest themselves. And obviously diet plays a huge role in that now I know you're a meat eater, like I am. And I've often heard you dispel a lot of the vegan vegetarian. Yes. And not saying attacking vegans and vegetarians, but just just dispelling the myth that you you can't be healthy unless you're eating an entirely plant based diet. Yeah, definitely worth pushing back against because there's so much money that goes into
Starting point is 00:29:23 the promotion of plant basedbased diets, right? But yeah, no, I'm an unapologetic omnivore. I think that people are best suited eating both plants and animals and You know, there's like the ethical question that always arises and I think that's a good, you know, these are important questions animal treatment in this country particularly in the CAFO system is like Really aberrant and it's not great for the environment either but from a nutritional value I think it's you know should not be controversial that animal source foods are can play a really important role in in the optimized diet there they comprise some of the most nutrient dense foods on the planet
Starting point is 00:30:02 red meat in particular I think it's think it's a repository for not just really high-quality protein, the highest quality protein, but creatine, carnosine, vitamin E, you got a tiny amount of omega-3s in grass-fed, grass-finished red meat, taurine even. There are carnit nutrients, nutrients that are found exclusively in animal source foods that I think we shouldn't be neglecting. And so, yeah, I take a really unapologetic stance. And the epidemiology surrounding red meat is really terrible. It's most of the time I find can't be trusted, you know, barely scientific uses called food frequency questionnaires where, you know, within the category of red meat, you'll see hamburgers,
Starting point is 00:30:50 you know, at the population level, people who are eating more hamburgers or eating more fast food. And it's like, is it the bun? Is it the high fructose corn syrup ketchup on the burger? Is it the French fries that, you know? Exactly. Is it the shake that came with it? A hundred percent.
Starting point is 00:31:03 So, you know, observational research tends to paint red meat as a dietary boogeyman. You know, those observations, those associations are easy to find. Red meat associated with increased risk of colorectal cancer, you know, all this stuff. But the question, the issue is really diet quality. Randomized control trials do not bear out those observations. And those observations also, those increase in risks that you tend to see, tend to be very small.
Starting point is 00:31:29 They're increased, the risks are relative risk, increases in relative risk. Hey guys, let's talk about meat for a minute. Did you know that 96% of the beef sold in stores is not grass-fed? That's right, most beef comes from cows fed a grain-based diet in feedlots which isn't even healthy for you or the cow. And even if a label says grass-fed,
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Starting point is 00:32:30 grass-fed and grass-finished beef, lamb, bison, as well as pasture-raised pork and chicken to be delivered straight to your door next week. She delivers to all 50 states, so why settle for mystery meat from the store when you can eat meat that nourishes your body and restores the earth? Visit parkerpastures.com today and you'll get 25 bucks off your order. That's parkerpastures.com and get $25 off your first order. Now let's get back to the Ultimate Human Podcast. Interestingly, we, I didn't mean to cut you off, but we talked about this yesterday on
Starting point is 00:33:03 a podcast that a pediatrician on and we were talking about statistical data. I have a background in probability and statistics and mortality modeling. And by asking a different question, you can get a completely different answer from the same data. And one of the things that we were discussing was if you have, you know, 100 people in a population, for example, and one person is helped by, let's say a pharmaceutical intervention. And you tweak that pharmaceutical intervention, and now 1.5 people out of 100 are helped. Well, that's a 50% increase in the
Starting point is 00:33:39 efficacy. And so now, you know, you know, consumer sees, well, there's a 50% improvement in what you would think, well, it went from one to 50 out of 100. But it didn't, it went from one and two one and a half out of 100. The stat claims a 50% improvement, which I guess, hyper technically is true. But you know, when you when you're looking at the data, it's misleading and that's a lot of what happens with epidemiological studies. Yeah, 100%.
Starting point is 00:34:09 It's like if you are, if they take a group of, I mean we'll just say like 100 people and you know they see four of those people getting a negative health outcome related to a certain variable like red meat consumption, you know, four of those people out of a hundred and then, you know, another cohort that, you know, maybe is meat avoidant, you'll see three people, you know, have the same health outcome. The headline will be 25% 25% reduction, risk reduction, right? But it's just going from four to three. And it's like red meat maybe was assessed via these food frequency questionnaires, which are notoriously inaccurate. And there's all of these other variables. There's healthy user bias.
Starting point is 00:34:53 There's multi-colinearity. There's all of these other- Multi-what? Colinearity, which I got into a fight. Multi-colinearity. Damn, I've been in the industry a long time. I never heard of that. I got into a debate on the.
Starting point is 00:35:05 Yeah, yeah, yeah. I got into a debate with with one of these like vegan science communicators. Their whole shtick is like promoting, you know, their their activism around that diet, that lifestyle. And yeah, and you know, there was a they can be so pedantic, you know, and we got into this debate about semantics and healthy user bias versus multicoloniality. They're related concepts.
Starting point is 00:35:30 But yeah, so that's why those kinds of studies, I think, are really not trustworthy. They're useful for generating hypotheses. But the randomized controlled trials don't really tend to show any negative health effect from the consumption of red meat. In fact, one meta-analysis of randomized control trials was just published that found that of all the cardiovascular biomarkers that were assessed across myriad randomized control trials using red meat as an intervention, the only potentially negative effect to come from red meat consumption up to about six ounces of,
Starting point is 00:36:07 or on average six ounces of red meat consumed per day was a tiny, tiny, tiny bump in LDL cholesterol. And it's like, is that bad? No, probably not. Yeah, so. No, it's not. I did a whole podcast on this with Dr. Arseen Mahotra, he's a cardiologist out of the UK.
Starting point is 00:36:23 He's up for a cabinet position in the new administration. It's not the American Heart Association, but it's another cardiovascular society. And running the Health and Human Services. And he said, the very first thing that I'm gonna do is I'm going to de-correlate LDL's direct risk for cardiovascular disease. And we saw this in our mortality tables where we used large data because when we were determining mortality, we used voluminous pools of data because we were putting people
Starting point is 00:37:01 into a cohort of a thousand lives lives and we didn't use randomized clinical trials. We used actual data, day, date, time, location and cause of death and triangulated that back into the record. And if elevated LDL cholesterol was correlated to decreased mortality, we would have had it as a risk factor, what we call morbidity factor or co morbidity factor, but it wasn't in fact, it was it was oppositely correlated in older ages that the higher the LDL cholesterol, the more it was correlated to longevity. We didn't, at the
Starting point is 00:37:34 time that I was there process death claims on centenarians, which we would see from time to time. Sometimes in life insurance, the policy does what they call endows. So if you actually make it to age 100, the death claim pays. So kind of fun to like screw your children and make it to 101 years old. Dad just got his life insurance. 101 I'm going on a bender. I just got 10 million tax free. But what was interesting about these death claims is many of them died in, you know,
Starting point is 00:38:08 hospital or scared living facilities or, you know, other kind of areas where we had blood work. And universally across the board, they had what we would consider to be, you know, elevated levels of LDL cholesterol. And yet these are the centenarians. And great longevity. Yeah, and great longevity. So he and I went deep down the rabbit hole with this.
Starting point is 00:38:29 If you want to check that podcast out, it's Dr. Asim Malhotra. But I saw a tweet of yours that I want to dig into because I happen to agree with it. Agree with most of your tweets. Aside from being funny, you've got some great one-liners. But you tweeted about the five best sports supplements, creatine, beta-alanine, nitrates, caffeine, and protein.
Starting point is 00:38:53 And I wonder if we might discuss that. I mean, obviously, I think protein is pretty well vetted and discussed. I don't think anybody considers protein to not be excellent for sports nutrition. But what about beta-alanine, creatine, nitrates, caffeine? Why did those make your top five list? Yeah, well actually that was a review that just came out
Starting point is 00:39:15 and it sought to elucidate the five top sports supplements. So the five top sports supplements, according to this new review, was creat creatine which was sort of the king Mm-hmm, I would by the way agree with that. Yeah, I think is the most underserved nutrient in 40 plus year old females. Mm-hmm, you know, especially perimenopausal Pre menopausal postmenopausal women. Yeah. Yeah, it's the bomb. I mean it has a really long historical track record for safety and efficacy. And they're now starting to,
Starting point is 00:39:53 research is starting to mount showing that it has a cognitive benefit, supplemental creatine. It can improve cognition when people are under-slept, which is a great thing. Pretty much everybody. Yeah, right. It might have a cardiovascular health benefit. So I think creatine is amazing.
Starting point is 00:40:10 I take about five grams a day and it seems to be, I mean, save for people with kidney disease and other medical conditions. It seems to be very safe. In what form of creatine? Monohydrate by the monohydrate or the HCl? Yeah. Most of the research is on creatine monohydrate. Yeah, so creatine HCl might be as efficacious and safe,
Starting point is 00:40:32 but I don't think we know. And monohydrate is super cheap, and it's very easy to find. Most of the research centers on that. And how does beta alanine play into that? That's a good question. I mean, beta alanine is not something that I'm all that familiar with, actually, which is part of the reason why I was reading
Starting point is 00:40:52 that research review, because it's not something that I currently use. But it did seem to make the list. And there is this interesting thing. It does give you tingles when you take it. Right. Like a niacin flush or something? Yeah, something like that.
Starting point is 00:41:05 It does feel very similar to that. But yeah, the fact that I made the top five, I mean, that's very interesting. Yeah, and then nitrates, because we classically would look for nitrate-free meats and consider nitrates to be things that are embedded in highly processed meats. Yeah.
Starting point is 00:41:20 And are these the same nitrates? Same. Wow. Yeah, same. So maybe we're coming full circle on the well nitrates and basically support your body's nitric oxide pathway, which which Normal normalizes blood pressure can reduce blood pressure And also increase blood flow. Mm-hmm So, I mean everybody's familiar with the certain pharmaceutical that works to increase blood flow in a region of the body, right? That's you know the certain pharmaceutical that works to increase blood flow in a region of the body.
Starting point is 00:41:45 That's you know, facilitative of sex. But interestingly, there have been some reports and actually some research on people taking that same drug Viagra, if you haven't guessed, in the pre-workout setting. And it seems to actually improve muscle protein synthesis on par with one to 200 milligrams of testosterone in a small study. So nitrates, yeah, might have a really powerful effect. I mean, not least of which you're going to probably see a better pump from it, but it might have an enduring impact on muscle protein synthesis.
Starting point is 00:42:20 Yeah. And just so we don't leave the vegans and vegetarians totally out of the conversation, like what are some important things for vegans and vegetarians to pay attention to? You know, I often just to highlight the fact that, you know, there's a widespread assumption that if it's not meat, it's healthy. But you know, if you look at Beyond Burgers and non burgers, and, and you read the list of ingredients in there, the number that I can't even pronounce
Starting point is 00:42:45 and don't even recognize. You know, polysorbate 80 and there's just all kinds of binders, fillers, gelatins, thickening agents, you know, things that are put in there for for consistency that you do not find anywhere naturally in nature. But for vegans and vegetarians, what are they particularly depleted in? And what do they need to replace that a meat, you know, diet is getting? Yeah, that's a good that's a good question. I mean, you know, vitamin B12, we all know is is most easily obtained from eating animal source foodsourced foods. But if I were gonna go vegan,
Starting point is 00:43:25 which I won't be anytime soon, but I would say a nice omega-3 supplement, like an algal-based omega-3 for DHA fat, very useful. I don't think we can rely on plant-based forms of omega-3s to adequately support our needs from an omega-3 standpoint. So, you know, I would definitely be supplementing with preformed omega-3 fatty acids.
Starting point is 00:43:51 Algae is a great option there. I would also supplement with creatine. You know, at this point, the evidence is pretty strong, strongly in favor of creatine. Yeah. So I would definitely take that. Creatine is found exclusively in animal-sourced foods. Yeah, I agree. And it's synthesized. So it's vegan. You know, you definitely take that. Creatine is found exclusively in animal-sourced foods. Yeah, I agree.
Starting point is 00:44:05 And it's synthesized. So it's vegan. You know, you could take that. Those would be my two, you know, supplemental, I guess, like the high leverage, you know, nutrients that I would look into. There are a lot of other nutrients, though, that I think are valuable that vegans likely under-consume. I would put choline in there which is really important for brain health.
Starting point is 00:44:30 You can find choline in plant-based foods. Choline does exist I believe in soybeans and cruciferous vegetables but in much lower concentration than animal-sourced foods. So you can supplement it from a vegan source or from a vegetarian source. I think so. Yeah, there's like- Well, you definitely it from a vegan source or from a vegetarian source. I think so. Yeah, there's like city. Well, you definitely could get a choline supplement. Yeah, yeah.
Starting point is 00:44:49 Yeah, you're right. Yeah, like City Choline and stuff. Because I think what you know, you and I are both involved in really, as we discussed at the beginning, putting our platforms behind this Make America Healthy Again movement, which I'm super excited about, and hoping that it can coalesce into, you know, more of a well organized movement. A lot of us are trying to do that. In a perfect world,
Starting point is 00:45:16 what do you see as, you know, what are the biggest threats right now to society because of our, you know, the corruption in our nutritional research and the corruption in our, you know, food supply chemicals in our food supply. Like, there's so much, you know, like banning red dye three was amazing. And then everybody, of course, everybody crawled out of the woodwork and said, What about a red dye number 40? And what about, you know, yellow 90? And I agree with that. But in the perfect world, where do we start? And and what
Starting point is 00:45:51 are some real actionable things that the government could do public policy wise or, you know, to restrict certain corruptive practices to make the biggest impact in the shortest amount of time? Great question. Yeah, I mean, I'll preface by saying I'm not formally involved in any way in the administration. Right, I'm not formally involved in the administration. We're kind of like tangentially at this point supporting.
Starting point is 00:46:18 It's a fantastic initiative. I remain totally optimistic. I know you are as well. But what can they do? I think for one, RFK Junior's, the motivation is there to uncouple some of the many conflicts of interest with our regulatory agencies, whether that's the FDA.
Starting point is 00:46:41 Almost 50% of the FDA's budget comes from what are called user fees, which are predominantly from the pharmaceutical industry. So getting the food and drug administration's budget comes from user fees. What is a user fee? So user fees are basically the application fees that these, you know, and other forms of fees that the pharmaceutical agencies pay into the FDA to, you know, I believe look at data with regards to drug trials and things like that. So sort of like administrative fees
Starting point is 00:47:13 that the pharmaceutical companies pay into the FDA. A proportion of that comes from the food industry, but most of it comes from the pharmaceutical industry. Yeah. Want to get an extra hour of quality good sleep every single night? Let me tell you how I do it. My wife and I sleep on 8Sleeps Pod 4 Ultra. This is a technology that fits over your mattress to cool or warm each side of the bed,
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Starting point is 00:48:18 get back to the ultimate human podcast. And what other areas could this movement really make big pendulum swings with, you know, small amounts of action? I've heard Kelly Means talk about ending the direct, you know, advertising to the consumer because that allows the control of the narrative and stops anybody from speaking out. Yeah. But what are some other areas where this Make America Healthy Again movement can make big strides in short periods of time? What are the muscos in the food supply?
Starting point is 00:48:50 Yeah. Well, I think that getting pharmaceutical ads off of TV, that's easier said than done to be fair. You know, a lot of these networks, I mean, if you watch the nightly news in America, I mean, most of the ads are for pharmaceutical drugs, you know? So I don't know the proportion to which the revenue of those companies, those conglomerates come from their advertising.
Starting point is 00:49:18 It's as high as 74% that I've read. Yeah. And, you know, but the crazy thing is that those ads are not even necessarily there to influence consumer spending, which is what we would, which is what even I assumed, you know, prior to Callie coming on to my show and pointing out that, no, they're actually spending that money to influence the platforms.
Starting point is 00:49:38 Right. You know, if you look at every GV share. To control the narrative and control the media. Exactly. As you've said. Yeah. So I think uncoupling that would be amazing. I think getting the conflicts of interest out of the USDA,
Starting point is 00:49:50 which I don't know how that's going to unfold. I mean, it was just announced that Trump nominated a former seat, I believe she was the CEO of one of the largest C2L lobbying groups to be the chief of staff for the USDA. So I don't know how it's all gonna shake out. At the point at which we record this, RFK has not been confirmed either. So I feel like there are a lot of moving parts.
Starting point is 00:50:12 And once he, if he gets officially confirmed, we might see major sweeping changes, but I personally would really love to see something that I would love to see. I think it should be banned that ultra processed foods are allowed to make health claims. I think it's really screwed up that you can, you know, that the least healthy foods in the supermarket make the loudest claims. Whereas the healthiest foods in the supermarket don't make any claims. You know,
Starting point is 00:50:46 most of the healthy, the healthiest foods in the supermarket, the grass-fed, grass-finished red meat, eggs, you know, extra virgin olive oil, like very, very seldom will you see any, even in avocados, like you don't see health claims on those foods, berries, you don't see health claims. Where do you find the health claims? On all the ultra-processed garbage foods, the seed oils, the commercial cereals, marketed towards children, of course. Yeah, wow, I actually never thought about that. That's a really good angle.
Starting point is 00:51:14 I mean, there's such a large percentage of our public policy nutritional research is funded by pharma. And I think this has got to be partially responsible for an upside down food pyramid, you know, Lucky Charms more nutritious than grass fed steak. And if there's any mechanism to flip that pyramid, or to be a little more truthful, I'm of the same mindset that you are, we shouldn't restrict free choice, right?
Starting point is 00:51:42 Like people buy cigarettes, they obviously I don't think anybody buys a carton of cigarettes and doesn't know what the risks are, but they're an adult and they know what the risks are, they can grab that off the shelf. I think what you're pointing out is intentionally misleading, you know, heart healthy, fortified, enriched, and, you know, high fiber and then on the back says high fiber diets are related to improvement in cardiovascular, reduction of cardiovascular disease, and improvement in a reduction in colon cancer, and things like that.
Starting point is 00:52:14 And leading you to believe that that box of cereal reduces your risk of colon cancer. I'm happy with products marketing how they've been produced. I think if it wants to say organic, great, you know, but it's the health claims. And I'm happy to say, you know, across the board, no health claims on even foods that I would consider healthy.
Starting point is 00:52:35 You know, I think it should just be a level playing field to inspire consumers to learn for themselves, to seek out their own sort of education around this topic. But it's like, once we start allowing foods to make health claims, that's actually, it sounds like on the surface that would be a good thing. You know, like a ranking system for foods and things like that. But there's just too much money involved. It's like, who's to say what's healthy and what's not?
Starting point is 00:52:57 Right. You know, so I think just just across the board banning health claims, I think that would be great. And then leaving it up to consumer choice. Yeah. Yeah, I would be great. And then leaving it up to consumer choice. Yeah. Yeah, I would agree with that too. I mean, I have high hopes for this movement to just create less leverage and more transparency because I think one of the major things that's gone wrong is we've privatized profits and
Starting point is 00:53:18 we've socialized the expense. And when I say socialize the expense, Medicaid, Medicare is picking up the cost of this burgaining, you know, explosive era of chronic disease and type 2 diabetes and morbid obesity. I know you've been outspoken about classifying obesity as a disease and certainly about it being genetic. So talk a little bit about that. about disease and certainly about it being genetic. So talk a little bit about that. I mean, you think that obesity should be considered a disease? Yeah, I think it's a, you know, I mean, it's highly
Starting point is 00:53:56 responsive to our diets and our lifestyle. So it's not something that we can, that we, that we're, that we're unable to address with our own agency in the world. But I push back, what I push back primarily against is the notion that it's genetic. There are certainly genetic influences, but this idea that it's primarily genetic, that's BS. I mean, obesity has tripled over the past 50 years. Our genes have not changed all that much, you know. But our lifestyle, our food environment
Starting point is 00:54:30 has dramatically changed. Absolutely. And so... And from a mental health perspective, what do you think is most, because you're a huge mental health advocate, but what has most dramatically impacted our mental health? And for those folks that are listening,
Starting point is 00:54:44 we just gave five of the top, you know, supplements for, for fitness and for sport. What about for good mental health for cognitive health, we've actually started the discussion on nicotine. yet. We had this discussion in Baja, but I'm on the precipice of it because I've heard Huberman talk about it, you know, Ben Greenfield's big on it. Dave Asprey and I spoke about it on his podcast, you and I have spoken about it. I love to because I think as soon as you say nicotine, people think cigarettes vaping, you know, we're obviously not right, you know, talking about those things. But nicotine. Yeah, nicotine is a, I mean, I, there's no such thing as a free lunch. And
Starting point is 00:55:30 I think nicotine has some benefits and it has some definite downsides. The benefits are that it improves cognitive function. It's a well studied neurotropic. It might benefit mental health. Also with fear extinction and things like that, there are studies that have shown that. I've actually seen some of the cancer binding site research, which seems to be very promising with even some oncologists recommending pure nicotine patches for patients that are going through oncology treatment.
Starting point is 00:56:00 I don't purport to know the science behind that. But if we just stick into cognitive function, you know, as a cognitive enhancer, I would say the majority of people over 40 would say I have some level of brain fog, some level of short term recall issues or some level of focus and concentration issues. So if we're just isolating, you know, cognitive function and in neurotropics, where do you fall on what you feel are the best long-term for our brain health? Aside from maybe the short-term impact of nicotine.
Starting point is 00:56:36 Generally speaking, like aside from nicotine, I would say, you know, choline is definitely important. I try to, you know to prioritize choline in my diet from eggs, red meat, fish, things like that. I think collagen plays an important role in longevity and systemic health. I think brain health probably too. I think the problem with collagen is people think
Starting point is 00:56:58 that we can target direct collagen, right? If you eat collagen, it shows up as collagen in your skin, but I always use the analogy that we don't eat our nails to grow our nails or eat our hair to grow our hair. And collagen is going to provide, you know, it's an incomplete protein. It won't really build muscle, but I think it can become amino acids which can then become collagen, alacin, fibrin in the skin. Do you take it? I don't take collagen.
Starting point is 00:57:21 I take these. I take these perfect aminos because that's all eight of the essential amino acids and these actually have nucleotides in them too. And I take it because that's such a low caloric impact, less than two calories and but it provides the equivalent of 29 grams of whey protein. So especially you know working out in a fasted state, you know I find that the essential amino acids, they're essential for a reason. And if you look at metabolic processing conversion, as soon as you're deficient, and even a single one of the essential amino acids, the balance of those
Starting point is 00:57:56 are going to become fat or sugar. So the eight essential amino acids in the right ratio is critical. And obviously you can get them from high protein sources. But I think that... Way better than BCAAs alone. Yeah, yeah. You want the full complex. Yeah.
Starting point is 00:58:14 Because the branch chain amino acids are just leucine, isoleucine, valine. And usually they're in the right ratios, that 2 to 1-1 ratio. But the branch chain amino acids are only three of the necessary amino acids. And I think the old adage used to be, well, BCAAs are either metabolized at the muscle level or they're the most commonly used at the muscle level. So we should take branch chain amino acids prior to a workout or during a workout. I think you should take full spectrum of the essential amino acids prior to workout or during a workout. I think you should take full spectrum of the essential amino acids
Starting point is 00:58:47 prior to workout or during a workout so that you can build anything from that complete protein. You build natural killer cells, you build collagen, you can build muscle. You can build you can build anything from those essential amino acids. Well, this is amazing, man. I'm super excited about, you know, anything that we can do and our peers can do to have a positive impact on this Make America Healthy Again movement. I'm also not directly involved with the administration,
Starting point is 00:59:12 but tangentially, you know, and significantly supporting that movement. So as you know, I ask all my podcast guests, and you can't give me the same answer that you gave last time. Should we look up his last answer? Ooh, I wonder what it was. all my podcast guests and you can't give me the same answer that you gave last time. Should we look up his last answer? I asked them all the same question at the end of the podcast. Before we go into my VIP community and after you answer this, we're going to go into a private room. If you're interested in becoming an ultimate human VIP, you can go to the ultimatehuman.com
Starting point is 00:59:43 and just sign up to be one of my VIP ultimate humans, we do private podcasts, I do a lot of one on one in group settings, answering questions, we do challenges, where we're just building an incredible community of like minded folks, and I get discounts on all of the products that that I endorse. But before we go into the private podcast for my VIP community, I ask all the guests the same question, you know, what does it mean to you to be an ultimate human? Damn.
Starting point is 01:00:17 I was the shortest answer we've ever had. Great. Thank you, Max. I forget. I completely forgot what I how I answered it the good time. I don't know, forgot how I answered it the first time. I don't know. For some reason, my brain is going to like James Bond. To be really good at karate and shooting with a gun. Like strong in body and in intention and in values and to be a high integrity person, to be a self-sufficient
Starting point is 01:00:48 person. I think that's, you know, and obviously health I think is a crucial one to embody, making sure that you're strong, that you're, you know, taking care of your body, that you're prioritizing self-care. And then I also think it's important to show up in the world presentable, and to have respect for not just your body and your mind, spiritually, your relationships and all that stuff, but also how you're perceived. Some people scoff at appearance and things like that.
Starting point is 01:01:26 Like it doesn't matter, it's shallow. But I think like because my mind went to James Bond, I'm also thinking about, well, he's a person who dressed really well and he showed up really well and he was always presentable. And I think that's why he's such an iconic character. I happen to be a big James Bond fan. I think everybody growing up was a big James Bond fan. Favorite Bond?
Starting point is 01:01:48 Who's your favorite Bond? Who was the English Bond? The heavy accent English actor. I'm having a brain. What was it? Sean Connery. City OG. Well, it was actually Sean Connery.
Starting point is 01:02:01 He just faked the British accent. Did he? Oh, yeah, I guess. Yeah, he did. He faked a really thick British accent. But I love the Sean. Mine is Daniel Connery was like he was a badass at seventy five. Yeah, yeah, yeah. Yeah, he was an old Eastwood, you know, like kind of like tougher and more chiseled at seventy five than at forty five. He was, yeah.
Starting point is 01:02:25 Daniel Craig for me is the goat. Yeah. Roger Moore? Roger Moore is your favorite. Cool. I'm so interested to know who the next bond is. Maybe it'll be you, Gary. Hey, I'm in.
Starting point is 01:02:39 Universal Studios, I'm here if you guys want to send me a contract. Well, guys, as always, I'll put the links to any of the topics that we talked about below to the extent that they're research. I'll also try to dig up the studies that you referred to if you help my team get those, so I can link those in the podcast below. Where can people find you?
Starting point is 01:02:58 My audience, for the most part, is familiar with you. But where can people find you? Yeah, my podcast, The Genius Life is my pride and joy so come over and listen to that if you're into podcasts as I'm sure you are if you listen to this. And I'm also very active on X and Instagram which I know you are as well. Very, okay.
Starting point is 01:03:17 Well, VIPs, we'll see you in the private room and the rest of you guys until next time, that's just science.

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